keyword
https://read.qxmd.com/read/38528463/one-year-monitoring-of-retinal-morphologic-and-functional-changes-in-traumatic-optic-neuropathy-patients
#21
JOURNAL ARTICLE
Myungjin Kim, Helen Lew
BACKGROUND: To analyze the morphologic and functional change in traumatic optic neuropathy (TON) divided by the mechanism of optic nerve injury. METHODS: A retrospective analysis of 58 patients who were diagnosed as monocular TON from February 2015 to August 2021 was conducted at in CHA Bundang Medical Center in Seongnam, South Korea. The patients visited the clinic of the department of ophthalmology for more than 6 months and at least 4 times during this period...
March 25, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38528273/vancouver-b2-periprosthetic-hip-fractures-treatment-fix-or-replace-a-retrospective-study-comparing-both-techniques
#22
JOURNAL ARTICLE
Yuri Lara-Taranchenko, Josep F Nomdedéu, Víctor M Barro, José V Andrés Peiró, Ernesto Guerra-Farfán, Jordi Selga, Jordi Tomás-Hernández, Jordi Teixidor Serra, Vicente Molero, Diego Collado, Iñaki Mimendia, Alejandro Hernández, Juan A Porcel-Vázquez
INTRODUCTION: Vancouver B2 periprosthetic hip fractures involve stem stability and they have been classically treated with revision surgery. Crucial factors such as age, clinical comorbidities and functional status are often neglected. The current study aims to compare clinical outcomes between patients treated with open reduction and internal fixation (ORIF) or femoral stem exchange. METHODS: This is a retrospective study that includes all Vancouver B2 periprosthetic hip fractures in a tertiary referral hospital from 2016 to 2020...
March 25, 2024: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://read.qxmd.com/read/38528252/comparison-of-the-medial-midline-and-the-anterolateral-portal-in-ankle-arthroscopy-for-the-treatment-of-osteochondral-lesions-of-the-medial-talus
#23
JOURNAL ARTICLE
Piqian Zhao, Zijie Pei, Junhui Xing, Mingyang Gao, Changbao Wang, Yingjie Xu, Hongtao Zhang, Yu Cheng
PURPOSE: To compare the clinical efficacy and complication rates between the medial midline and anterolateral portals in ankle arthroscopy for treating medial osteochondral lesions of the talus (OLTs). METHODS: We retrospectively analyzed patients with medial OLTs who underwent either a dual medial approach (via the medial midline and anteromedial portal) or a traditional approach (via the anterolateral and anteromedial portal) between June 2017 and January 2023...
March 25, 2024: International Orthopaedics
https://read.qxmd.com/read/38528235/amino-acids-to-prevent-cardiac-surgery-associated-acute-kidney-injury-a-randomized-controlled-trial
#24
JOURNAL ARTICLE
Masahiro Kazawa, Daijiro Kabata, Hisako Yoshida, Kimito Minami, Takuma Maeda, Kenji Yoshitani, Hitoshi Matsuda, Ayumi Shintani
BACKGROUND: This study aimed to examine the preventive effect of amino acids on postoperative acute kidney injury (AKI). METHODS: This was single-center, patient- and assessor-blinded, randomized controlled trial. Patients who underwent aortic surgery with cardiopulmonary bypass were included. The intervention group received 60 g/day of amino acids for up to 3 days. The control group received standard care. The primary outcome was the incidence of AKI...
March 26, 2024: JA Clinical Reports
https://read.qxmd.com/read/38527558/dapagliflozin-ameliorates-hepatic-steatosis-via-suppressing-lxr%C3%AE-mediated-synthesis-of-lipids-and-bile-acids
#25
JOURNAL ARTICLE
Zijie Jin, Ruotong Yin, Yan Yuan, Chen Zheng, Peng Zhang, Yalin Wang, Hongbo Weng
Nonalcoholic fatty liver disease (NAFLD) prevalence is rising globally with no pharmacotherapies approved. Hepatic steatosis is closely associated with progression and prognosis of NAFLD. Dapagliflozin, kind of sodium-glucose cotransporter 2 (SGLT2) inhibitor, was found to improve NAFLD in clinical trials, while the underlying mechanism remains poorly elucidated. Here, we reported that dapagliflozin effectively mitigated liver injury and relieved lipid metabolism disorders in vivo. Further investigation showed that dapagliflozin markedly suppressed Liver X Receptor α (LXRα)-mediated synthesis of de novo lipids and bile acids (BAs)...
March 23, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38527493/rural-vascular-trauma-time-to-care
#26
JOURNAL ARTICLE
Kirran Bakhshi, Heather Rhodes-Lyons, Ayman Ahmed
Previous rural vascular trauma research has focused on case series dating back two decades. The current research aims to measure clinical decline in comparison to time to care in rural vascular trauma. This single-center retrospective cohort study included adult trauma patients with vascular injury who were admitted to a level II trauma center. Multivariable logistic regression assessed the effect of clinical decline based on arrival within the golden hour. 149 patients were included. For every 1 unit increase in the shock index ratio, there was 99...
March 25, 2024: American Surgeon
https://read.qxmd.com/read/38527400/the-redox-sensitive-gsk3%C3%AE-is-a-key-regulator-of-glomerular-podocyte-injury-in-type-2-diabetic-kidney-disease
#27
JOURNAL ARTICLE
Mengxuan Chen, Yudong Fang, Yan Ge, Shuhao Qiu, Lance Dworkin, Rujun Gong
Emerging evidence suggests that GSK3β, a redox-sensitive transducer downstream of insulin signaling, acts as a convergent point for myriad pathways implicated in kidney injury, repair, and regeneration. However, its role in diabetic kidney disease remains controversial. In cultured glomerular podocytes, exposure to a milieu of type 2 diabetes elicited prominent signs of podocyte injury and degeneration, marked by loss of homeostatic marker proteins like synaptopodin, actin cytoskeleton disruption, oxidative stress, apoptosis, and stress-induced premature senescence, as shown by increased staining for senescence-associated β-galactosidase activity, amplified formation of γH2AX foci, and elevated expression of mediators of senescence signaling, like p21 and p16INK4A ...
March 16, 2024: Redox Biology
https://read.qxmd.com/read/38526925/prevention-diagnosis-and-management-of-intraoperative-spinal-cord-injury-in-the-setting-of-spine-surgery-a-proposed-care-pathway
#28
JOURNAL ARTICLE
Nisaharan Srikandarajah, Nader Hejrati, Mohammed Ali Alvi, Ayesha Quddusi, Lindsay A Tetreault, Nathan Evaniew, Andrea C Skelly, Sam Douglas, Vafa Rahimi-Movaghar, Paul M Arnold, Steven Kirshblum, Brian K Kwon, Michael G Fehlings
STUDY DESIGN: This study is a mixed methods approach. OBJECTIVES: Intraoperative spinal cord injury (ISCI) is a challenging complication in spine surgery. Intra-operative neuromonitoring (IONM) has been developed to detect changes in neural function. We report on the first multidisciplinary, international effort through AO Spine and the Praxis Spinal Cord Institute to develop a comprehensive guideline and care pathway for the prevention, diagnosis, and management of ISCI...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526593/trans-2-nonadecyl-4-hydroxymethyl-1-3-dioxolane-tnhd-purified-from-freshwater-clams-markedly-alleviates-dimethylnitrosamine-induced-hepatic-fibrosis
#29
JOURNAL ARTICLE
Ya-Ru Kuo, Chen-Yu Tsai, Wei-Sheng Lin, Chi-I Chang, Ching-Shu Lai, Min-Hsiung Pan
Liver fibrosis occurs due to injury or inflammation, which results in the excessive production of collagen and the formation of fibrotic scar tissue that impairs liver function. Despite the limited treatment options available, freshwater clams may hold promise in the treatment of liver fibrosis. In this study, we demonstrated the effects of ethanol extract of freshwater clam (FCE), ethyl acetate extract of FCE (EA-FCE), and trans-2-nonadecyl-4-(hydroxymethyl)-1,3-dioxolane (TNHD) on liver fibrosis induced by dimethylnitrosamine (DMN)...
March 15, 2024: Journal of Food and Drug Analysis
https://read.qxmd.com/read/38525869/-no-zone-approach-in-the-management-of-penetrating-neck-injuries-an-australian-tertiary-trauma-centre-experience
#30
JOURNAL ARTICLE
Meera L Chandrananth, Jordan D Lee, David Read, Rose Shakerian
PURPOSE: Penetrating neck injuries (PNIs), defined as deep to the platysma, can result in significant morbidity and mortality. Management has evolved from a zone-based approach to a 'no zone' algorithm, resulting in reduced non-therapeutic neck exploration rates. The aim of this study was to examine PNIs and its management trends in an Australian tertiary trauma centre, to determine if a 'no zone' approach could be safely implemented in this population, as has been demonstrated internationally...
March 25, 2024: ANZ Journal of Surgery
https://read.qxmd.com/read/38525608/targeted-gene-deletion-or-antagonism-of-the-prostaglandin-e2-ep3-receptor-protects-against-cardiac-injury-postmyocardial-infarction
#31
JOURNAL ARTICLE
Timothy D Bryson, Shaheen Y Bhat, Carlin Moore, David Taube, Jiang Xu, Edward Peterson, Pamela Harding
BACKGROUND: Prostaglandin E2 acts through 4 G-protein-coupled receptors (EP1-EP4). We previously reported that activation of the EP3 receptor reduces cardiac contractility, and its expression increases after a myocardial infarction (MI), mediating the reduction in cardiac function. In contrast, cardiac overexpression of the EP4 receptor in MI substantially improves cardiac function. Moreover, we recently reported that mice overexpressing EP3 have heart failure under basal conditions and worsened cardiac function after MI...
March 25, 2024: Circulation. Heart Failure
https://read.qxmd.com/read/38525510/an-investigation-into-the-frequency-and-risk-factors-of-low-back-pain-following-surgical-treatment-of-isolated-calcaneal-fractures
#32
JOURNAL ARTICLE
Dilek Bayraktar, Cengizhan Özgürbüz, Anıl Murat Öztürk, Salih Kemal Aktuğlu, Nadir Özkayın
OBJECTIVE: This study aimed to determine the frequency of low back pain after calcaneal fractures treated with open reduction internal fixation (ORIF) and the risk factors that cause this condition. METHODS: Thirty-one patients (27 males and 4 females) who underwent surgery for a unilateral calcaneal fracture between 2016 and 2020 and had no complaints of low back pain before fracture surgery were included in the study. The patients were divided into 2 groups: those who developed low back pain after the operation and those who did not...
January 2024: Acta Orthopaedica et Traumatologica Turcica
https://read.qxmd.com/read/38524724/comparison-of-sociodemographic-and-radiographic-features-in-distal-radio-fracture-treatment-hand-surgeons-versus-non-specialists
#33
JOURNAL ARTICLE
Rafael Bulyk Veiga, Renê Hobi, Ricardo Pereira Marot, Gustavo Zeni Schuroff, Roberto Luiz Sobania, Ivan Killing Kuhn, Ana Lucia Campos Faccioni
Objective:  This study evaluated sociodemographic and radiographic features of patients with distal radial fractures treated at a trauma hospital in southern Brazil, comparing those treated by hand surgery specialists (group 1) and non-specialists (group 2). Methods:  This study consists of a retrospective cohort of 200 patients treated in 2020. After reviewing medical records and radiographs, the following parameters were analyzed: age, gender, trauma mechanism, laterality, associated comorbidities and fractures, fracture classification (AO), radial height, radial inclination, and volar inclination...
February 2024: Revista Brasileira de Ortopedia
https://read.qxmd.com/read/38524599/single-cell-and-bulk-rna-sequencing-highlights-the-role-of-m1-like-infiltrating-macrophages-in-antibody-mediated-rejection-after-kidney-transplantation
#34
JOURNAL ARTICLE
Qidan Pang, Liang Chen, Changyong An, Juan Zhou, Hanyu Xiao
BACKGROUND: Antibody-mediated rejection (ABMR) significantly affects transplanted kidney survival, yet the macrophage phenotype, ontogeny, and mechanisms in ABMR remain unclear. METHOD: We analyzed post-transplant sequencing and clinical data from GEO and ArrayExpress. Using dimensionality reduction and clustering on scRNA-seq data, we identified macrophage subpopulations and compared their infiltration in ABMR and non-rejection cases. Cibersort quantified these subpopulations in bulk samples...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524532/quantitative-proteome-and-lysine-succinylome-characterization-of-zinc-chloride-smoke-induced-lung-injury-in-mice
#35
JOURNAL ARTICLE
Rui Zhou, Zhiwei Tu, Daishi Chen, Wanmei Wang, Shuzi Liu, Linjun She, Zhan Li, Jihong Liu, Yabin Li, Yu Cui, Pan Pan, Fei Xie
The inhalation of zinc chloride (ZnCl2 ) smoke is one of common resources of lung injury, potentially resulting in severe pulmonary complications and even mortality. The influence of ZnCl2 smoke on lysine succinylation (Ksucc) in the lungs remains uncertain. In this study, we used a ZnCl2 smoke inhalation mouse model to perform global proteomic and lysine succinylome analyses. A total of 6781 Ksucc sites were identified in the lungs, with injured lungs demonstrating a reduction to approximately 2000 Ksucc sites, and 91 proteins exhibiting at least five differences in the number of Ksucc sites...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524360/comparative-analysis-of-surgical-outcomes-in-children-with-type-3-and-type-4-lateral-physeal-condylar-humerus-fractures-in-china-closed-reduction-percutaneous-pinning-crpp-vs-open-reduction-internal-fixation-orif
#36
JOURNAL ARTICLE
Md Fahim Muntasir Islam Sojib, Yan Song Wang
BACKGROUND: Lateral physeal condylar humerus fractures in pediatric patients aged 1-13 rank as the second most common elbow injury, occurring with a frequency ranging from 5% to 16.8%. There exists an ongoing debate regarding the surgical management of these fractures. This study aims to evaluate the efficacy of Open Reduction and Internal Fixation (ORIF) and Closed Reduction and Percutaneous Pinning (CRPP) as suitable surgical treatments for displaced unstable fractures of the lateral condyle physeal humerus in children...
August 2024: Journal of Orthopaedics
https://read.qxmd.com/read/38523964/unveiling-the-surge-a-comprehensive-analysis-of-e-scooter-related-injuries-at-an-urban-level-1-trauma-center-in-vilnius-lithuania-2018-2021
#37
JOURNAL ARTICLE
Kristupas A Suslavičius, Simonas Utkus, Valentinas Uvarovas, Tomas Sveikata, Sigitas Ryliškis
Background The surge in electric scooter (e-scooter) adoption in 2019 fueled by sharing platforms has raised safety concerns, leading to an increased incidence of e-scooter-related injuries. Despite regulatory efforts, there has been a notable rise in accidents, prompting a comprehensive investigation. This study conducted at the Republican Vilnius University Hospital (RVUH), a level 1 trauma center, is one of the first in the Baltic States aiming to analyze the causes, severity, and frequency of e-scooter injuries from 2018 to 2021...
February 2024: Curēus
https://read.qxmd.com/read/38523948/suture-anchor-repair-for-distal-patellar-tendon-avulsion-in-tibial-tubercle-fractures-a-technical-description-and-report-of-two-cases
#38
Robert Wood, Jacqueline Krumrey, Kathryn Palomino, Megan Hicks
Tibial tubercle avulsion fractures, though rare, pose a significant challenge in pediatric orthopedics, particularly in athletic adolescents. For nondisplaced fractures, conservative treatment involves the use of braces or casts, while displaced fractures necessitate operative intervention, often through screw fixation. Concomitant soft tissue injuries should also be identified and addressed operatively to ensure complete repair of the extensor mechanism. This paper introduces a method for open reduction and internal fixation (ORIF) of tibial tubercle fractures with suture anchor repair of the distal patellar tendon avulsion...
February 2024: Curēus
https://read.qxmd.com/read/38523403/the-inhibition-of-marco-by-polyg-alleviates-pulmonary-fibrosis-via-regulating-mitochondrial-function-in-a-silicotic-rat-model
#39
JOURNAL ARTICLE
Meiyu Chang, Ning Li, Qiang Zhou, Yaomin Yan, Weiwei Xu, Yingzheng Zhao, Sanqiao Yao
Silicon dioxide (SiO2 )-induced pulmonary fibrosis is potentially associated with the impairment of mitochondrial function. Previous research found that inhibition of macrophage receptor with collagenous structure (MARCO) could alleviate particle-induced lung injury by regulating phagocytosis and mitigating mitochondrial damage. The present study aims to explore the underlying anti-fibrosis mechanism of polyguanylic acid (PolyG, MARCO inhibitor) in a silicotic rat model. Hematoxylin and eosin and Masson staining were performed to visualize lung tissue pathological changes...
March 24, 2024: Environmental Toxicology
https://read.qxmd.com/read/38522941/synthesis-of-ottonia-anisum-extract-mediated-zno-nps-and-their-local-anesthetic-analgesic-and-hcl%C3%A2-induced-acute-lung-injury-activities
#40
JOURNAL ARTICLE
Guiqin Fan, Jing Yu, Zhengzheng Tao, Xingjia Qian, Qinghong Qian, Jun Shu, Dongfang Shi, Luhong Shen, Bing Lu, Hong Lv
In this study, we outlined the green synthesis of Zinc oxide nanoparticles (ZnO NPs) using the plant-mediated method. Employing the nitrate derivative of Zinc and the extract from the native medicinal plant, Ottonia anisum, the nanoparticles were effectively produced. After obtaining a yellow-colored paste, it was meticulously dried, gathered, and set aside for subsequent examination. The UV-visible spectrometry analysis indicated an absorption peak at 320 nm, which is indicative of ZnO NPs. Characterization techniques, such as XRD and HR-TEM, confirmed the existence of agglomerated ZnO NPs with an average diameter of 40 nm...
March 25, 2024: Journal of Oleo Science
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