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https://www.readbyqxmd.com/read/28918444/left-atrial-volume-computed-by-3d-rotational-angiography-best-predicts-atrial-fibrillation-recurrence-after-circumferential-pulmonary-vein-isolation
#1
Teresa Strisciuglio, Giuseppe Di Gioia, Sofia Chatzikyriakou, Etel Silva Garcia, Emanuele Barbato, Peter Geelen, Tom De Potter
Left atrium (LA) size is a well-studied predictor of atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). Yet, there is still little agreement on the best imaging technique to size the LA, and on the most appropriate sizing parameter. Volumetric assessment of LA with three-dimensional rotational angiography (3DRA LA volume index) might be a valid alternative to the commonly used transthoracic echocardiography (TTE LA volume index). The aim of our study was to investigate whether LA volume by 3DRA at the time of PVI is able to predict the risk of atrial fibrillation recurrence...
September 16, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28918074/rapid-adenovirus-typing-method-for-species-identification
#2
Fabienne Rayne, Linda Wittkop, Clément Bader, Somar Kassab, Camille Tumiotto, Sylvie Berciaud, Harald Wodrich, Marie-Edith Lafon
Adenoviruses are characterized by a large variability, reflected by their classification in species A to G. Certain species, eg A and C, could be associated with increased clinical severity, both in immunocompetent and immunocompromised hosts suggesting that in some instances species identification provides clinically relevant information. Here we designed a novel "pVI rapid typing method" to obtain quick, simple and cost effective species assignment for Adenoviruses, thanks to combined fusion temperature (Tm) and amplicon size analysis...
September 13, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28901573/validation-of-a-novel-cartoseg%C3%A2-segmentation-module-software-for-contrast-enhanced-computed-tomography-guided-radiofrequency-ablation-in-patients-with-atrial-fibrillation
#3
EDITORIAL
Hasan Imanli, Shaun Bhatty, Jean Jeudy, Yousra Ghzally, Kiddy Ume, Rama Vunnam, Refael Itah, Mati Amit, John Duell, Vincent See, Stephen Shorofsky, Timm M Dickfeld
INTRODUCTION: Visualization of left atrial (LA) anatomy using image integration modules has been associated with decreased radiation exposure and improved procedural outcome when used for guidance of pulmonary vein isolation (PVI) in atrial fibrillation (AF) ablation. We evaluated the CARTOSEG™ CT Segmentation Module (Biosense Webster, Inc.) that offers a new CT-specific semi-automatic reconstruction of the atrial endocardium. METHODS: The CARTOSEG™ CT Segmentation Module software was assessed prospectively in 80 patients undergoing AF ablation...
September 13, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28892174/a-quantitative-comparison-of-the-electrical-and-anatomical-definition-of-the-pulmonary-vein-ostium
#4
Florian Spies, Michael Kühne, Tobias Reichlin, Stefan Osswald, Christian Sticherling, Sven Knecht
BACKGROUND: Anatomically guided pulmonary vein isolation (PVI) is the cornerstone of atrial fibrillation (AF) ablation. However, the position where to confirm electrical isolation is ill-defined. The aim of the current study was to quantify the relationship between the anatomical and electrical definition of the pulmonary vein ostium. METHODS: We analyzed 20 patients with paroxysmal AF undergoing PVI using radiofrequency energy and an electroanatomical mapping system...
September 11, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28886122/alteration-of-endothelin-1-mcp-1-and-chromogranin-a-in-patients-with-atrial-fibrillation-undergoing-pulmonary-vein-isolation
#5
K Lackermair, S Clauss, T Voigt, I Klier, C Summo, B Hildebrand, T Nickel, H L Estner, S Kääb, R Wakili, U Wilbert-Lampen
BACKGROUND: The relation between arrhythmias and stress is known. The aim of our current study was to elucidate whether plasma levels of previously described stress parameters are altered in highly symptomatic patients with atrial fibrillation (AF) per se and in patients undergoing ablation therapy by pulmonary vein isolation (PVI). METHODS: 96 patients with AF undergoing PVI were recruited. Plasma levels of Endothelin-1 (ET-1), MCP-1 and Chromogranin-A (CGA) were measured before and three months after ablation completed with clinical follow-up with respect to AF recurrence...
2017: PloS One
https://www.readbyqxmd.com/read/28883795/atrial-electrogram-fractionation-distribution-before-and-after-pulmonary-vein-isolation-in-human-persistent-atrial-fibrillation-a-retrospective-multivariate-statistical-analysis
#6
Tiago P Almeida, Gavin S Chu, Xin Li, Nawshin Dastagir, Jiun H Tuan, Peter J Stafford, Fernando S Schlindwein, G André Ng
Purpose: Complex fractionated atrial electrograms (CFAE)-guided ablation after pulmonary vein isolation (PVI) has been used for persistent atrial fibrillation (persAF) therapy. This strategy has shown suboptimal outcomes due to, among other factors, undetected changes in the atrial tissue following PVI. In the present work, we investigate CFAE distribution before and after PVI in patients with persAF using a multivariate statistical model. Methods: 207 pairs of atrial electrograms (AEGs) were collected before and after PVI respectively, from corresponding LA regions in 18 persAF patients...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28882497/pulmonary-vein-isolation-for-atrial-fibrillation-can-be-achieved-with-low-radiation-exposure
#7
Alex L Huang, Nadeem Mughal, Ferdinand Tabas, Natalie L Patterson, Wen Kai Wong, David Whalley, Logan Kanagaratnam
BACKGROUND: Atrial fibrillation is common and management by pharmacotherapy is limited by modest efficacy and significant toxicities. Pulmonary vein isolation (PVI) is a safe and effective alternative in select patients with atrial fibrillation. However, prolonged procedure time raises concerns of health risks from radiation exposure. This study aims to determine the significance of radiation exposure from PVI. METHODS: In this study, we retrospectively reviewed patient demographics, fluoroscopy time, entrance skin dose and dose area product in 80 cases of PVI, radiofrequency ablation for atrial flutter and diagnostic coronary angiogram performed in our institution...
August 8, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28880943/non-pulmonary-vein-mediated-atrial-fibrillation-a-novel-sub-phenotype
#8
Maureen Farrell, Zachary Yoneda, Jay Montgomery, Diane Crawford, Lauren Lee Wray, Meng Xu, Matthew J Kolek, Travis Richardson, Ricardo Lugo, Mohamed Metawee, Greg Michaud, Juan Carlos Estrada, Pablo Saavedra, Sharon Shen, Arvindh Kanagasundram, Christopher R Ellis, George Crossley, Dan Roden, M Benjamin Shoemaker
BACKGROUND: Atrial fibrillation (AF) is a mechanistically heterogeneous disorder, and the ability to identify sub-phenotypes ("endophenotypes") of AF would assist in the delivery of personalized medicine. We used the clinical response to pulmonary vein isolation (PVI) to identify a sub-group of patients with non-PV mediated AF and sought to define the clinical associations. METHODS: Subjects enrolled in the Vanderbilt AF Ablation Registry who underwent a repeat AF ablation due to arrhythmia recurrence were analyzed on the basis of PV reconnection...
2017: PloS One
https://www.readbyqxmd.com/read/28878099/distal-cuff-occlusion-a-novel-simple-approach-for-distal-embolic-protection-in-peripheral-vascular-intervention
#9
Shwan Jalal, Jihad A Mustapha, Howard S Rosman, Rajendra H Mehta, Thomas P Davis
AIM: To evaluate the feasibility, effectiveness, and safety of the cuff-occlusion method for distal embolic protection in peripheral artery disease. METHODS AND RESULTS: We evaluated 61 patients who underwent peripheral vascular intervention (PVI) for infrainguinal lesion at a single center where a blood pressure cuff occlusion method for distal embolic protection was utilized during the procedure. Primary endpoint included incidence of distal embolization, acute limb ischemia, or emergency limb amputation...
September 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28875448/clinical-outcomes-of-af-patients-treated-with-the-first-and-second-generation-of-circular-mapping-and-ablation-catheter-insights-from-a-real-world-multicenter-experience
#10
Giovanni Rovaris, Paolo De Filippo, Francesco Laurenzi, Gabriele Zanotto, Nicola Bottoni, Mattia Pozzi, Fabrizio Giofrè, Piergiuseppe De Girolamo, Emanuela Visentin, Elena Piazzi, Paola Ferrari
PURPOSE: Complete pulmonary vein isolation (PVI) is the best documented target for catheter ablation, and different technologies have shown comparable outcomes. The multielectrode phased-RF/duty cycled (PhRF/DC) pulmonary vein ablation catheter (PVAC) and its second generation (PVAC-GOLD) have shown promising clinical results in single and multicenter experiences. Our aim is to assess and compare the safety and efficacy in the real clinical practice among two generations of circular PhRF/DC catheters by performing PVI in patients suffering from recurrent atrial fibrillation (AF)...
September 5, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28861669/reproducibility-of-the-pleth-variability-index-in-premature-infants
#11
Wilhelmina J den Boogert, Hugo A van Elteren, Tom G Goos, Irwin K M Reiss, Rogier C J de Jonge, Victor J van den Berg
The aim was to assess the reproducibility of the Pleth Variability Index (PVI), developed for non-invasive monitoring of peripheral perfusion, in preterm neonates below 32 weeks of gestational age. Three PVI measurements were consecutively performed in stable, comfortable preterm neonates in the first 48 h of life. On each occasion, pulse oximeter sensors were attached to two different limbs for 5 min. Reproducibility was assessed with the intra-class correlation coefficient (ICC) and Bland-Altman analysis...
August 31, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28856145/ablation-of-long-standing-persistent-atrial-fibrillation
#12
REVIEW
Behram P Mody, Anoshia Raza, Jason Jacobson, Sei Iwai, Daniel Frenkel, Rhadames Rojas, Wilbert S Aronow
Atrial fibrillation (AF) is the most commonly encountered arrhythmia in the clinical setting affecting nearly 6 million people in United States and the numbers are only expected to rise as the population continues to age. Broadly it is classified into paroxysmal, persistent and longstanding persistent AF. Electrical, structural and autonomic remodeling are some of the diverse pathophysiological mechanisms that contribute to the persistence of AF. Our review article emphasizes particularly on long standing persistent atrial fibrillation (LSPAF) aspect of the disease which poses a great challenge for electrophysiologists...
August 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28855115/catheter-ablation-versus-medical-rate-control-in-atrial-fibrillation-and-systolic-dysfunction-camera-mri
#13
Sandeep Prabhu, Andrew J Taylor, Ben T Costello, David M Kaye, Alex Aj McLellan, Aleksandr Voskoboinik, Hariharan Sugumar, Siobhan M Lockwood, Michael B Stokes, Bhupesh Pathik, Chrishan J Nalliah, Geoff R Wong, Sonia M Azzopardi, Sarah Gutman, Geoffrey Lee, Jamie Layland, Justin A Mariani, Liang-Han Ling, Jonathan M Kalman, Peter M Kistler
BACKGROUND: Atrial fibrillation (AF) and left ventricular systolic dysfunction (LVSD) frequently co-exist despite adequate rate-control. Existing randomized studies of AF and LVSD of varying etiologies have demonstrated modest benefits with a rhythm control strategy. OBJECTIVE: To determine whether catheter ablation (CA) for AF could improve LVSD compared to medical rate-control (MRC) where the etiology of the LVSD was unexplained, apart from the presence of AF...
August 22, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28846806/apixaban-rivaroxaban-and-dabigatran-use-in-patients-undergoing-catheter-ablation-for-atrial-fibrillation-using-the-second-generation-cryoballoon
#14
Verena Tscholl, Abdullah Khaled-A Lsharaf, Tina Lin, Barbara Bellmann, Patrick Nagel, Klaus Lenz, Ulf Landmesser, Mattias Roser, Andreas Rillig
BACKGROUND: Data are limited on the safety of periprocedural anticoagulation with novel oral anticoagulants (NOACs) in patients undergoing pulmonary vein isolation (PVI) using the second-generation cryoballoon (CB) for the treatment of atrial fibrillation. HYPOTHESIS: We hypothesized that the incidence of acute periprocedural complications in patients undergoing PVI do not differ between patients treated with VKA compared to NOACs. METHODS: In 200 consecutive patients (mean age, 64...
August 28, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28846147/cardiac-mapping-and-pulmonary-vein-isolation-using-a-novel-ablation-catheter-with-tip-mini-electrodes
#15
Florian Heringhaus, Tanja Lotz, Lena Loehr, Julia Gelep, Sebastian Lask, Kaffer Kara, Andreas Mügge, Alexander Wutzler
BACKGROUND: Pulmonary vein isolation (PVI) is a standard treatment for atrial fibrillation (AF). Identification of gaps in the ablation line is difficult. Tip-ring electrograms from ablation catheters represent relative large areas of myocardial tissue. Recently, an ablation catheter with three mini-electrodes (ME) on the catheter tip with closer interelectrode spacing was introduced. The aim of our study was to evaluate the novel electrodes during PVI. METHODS: PVI was performed with an irrigated ablation catheter equipped with conventional electrodes and three additional radial tip electrodes...
August 28, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28841251/procedural-findings-and-ablation-outcome-in-patients-with-atrial-fibrillation-referred-after-two-or-more-failed-catheter-ablations
#16
Sanghamitra Mohanty, Chintan Trivedi, Carola Gianni, Domenico Giovanni Della Rocca, Eli Hamilton Morris, J David Burkhardt, Javier E Sanchez, Rodney Horton, G Joseph Gallinghouse, Richard Hongo, Salwa Beheiry, Amin Al-Ahmad, Luigi Di Biase, Andrea Natale
INTRODUCTION: This study reports the procedural findings and ablation outcome in AF patients referred after ≥2 failed PV isolation (PVI). METHODS: Three hundred and five consecutive AF patients referred after ≥2 PVI were included in the analysis. High-dose isoproterenol challenge was used to identify PV reconnection and non-PV triggers; the latter were ablated based on the operator's discretion during the index procedure. At the repeat procedure, non-PV triggers were ablated in all...
August 25, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28840587/study-design-and-rationale-for-biomedical-shirt-based-electrocardiography-monitoring-in-relevant-clinical-situations-ecg-shirt-study
#17
Paweł Balsam, Piotr Lodziński, Agata Tymińska, Krzysztof Ozierański, Łukasz Januszkiewicz, Renata Główczyńska, Katarzyna Wesołowska, Michał Peller, Radosław Pietrzak, Tomasz Książczyk, Sonia Borodzicz, Łukasz Kołtowski, Mariusz Borkowski, Bożena Werner, Grzegorz Opolski, Marcin Grabowski
BACKGROUND: Today, the main challenge for researchers is to develop new technologies which may help to improve the diagnoses of cardiovascular disease (CVD), thereby reducing healthcare costs and improving the quality of life for patients. This study aims to show the utility of biomedical shirt-based electrocardiography (ECG) monitoring of patients with CVD in different clinical situations using the Nuubo® ECG (nECG) system. METHODS: An investigator-initiated, multicentre, prospective observational study was carried out in a cardiology (adult and paediatric) and cardiac rehabilitation wards ...
August 25, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28836709/persistency-of-left-atrial-linear-lesions-after-radiofrequency-catheter-ablation-for-atrial-fibrillation-data-from-an-invasive-follow-up-electrophysiology-study
#18
Nebojša Mujović, Milan Marinković, Nebojša Marković, Goran Stanković, Gregory Y H Lip, Carina Blomstrom-Lundqvist, T Jared Bunch, Tatjana S Potpara
BACKGROUND: Data on the roof line (RL) and mitral isthmus line (MIL) reconnections after atrial fibrillation (AF) catheter-ablation (CA) are scarce. OBJECTIVE: We studied the RL and MIL completeness and localization of reconnection sites in consecutive patients after their first-ever AF-CA. METHODS: We prospectively included 41 consecutive AF patients who underwent predefined lesion sets of two circumferential lines (CLs) for ipsilateral pulmonary vein isolation (PVI) combined with a RL and lateral MIL...
August 24, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28819639/antioxidant-treatment-in-male-mice-prevents-mitochondrial-and-synaptic-changes-in-an-nmda-receptor-dysfunction-model-of-schizophrenia
#19
Aarron Phensy, Christopher Driskill, Karen Lindquist, Lan Guo, Vivek Jeevakumar, Bryan Fowler, Heng Du, Sven Kroener
Glutamate theories of schizophrenia suggest that the disease is associated with a loss of NMDA receptors, specifically on GABAergic parvalbumin-expressing interneurons (PVIs), leading to changes in the excitation-inhibition balance in the prefrontal cortex (PFC). Oxidative stress contributes to the loss of PVI and the development of schizophrenia. Here, we investigated whether the glutathione precursor N-acetyl cysteine (NAC) can prevent changes in synaptic transmission at pyramidal cells and PVIs that result from developmental NMDAR blockade and how these changes are related to mitochondrial dysfunction in the PFCs of mice...
July 2017: ENeuro
https://www.readbyqxmd.com/read/28800199/intracranial-elastance-is-increased-in-idiopathic-intracranial-hypertension
#20
Jason T Chisholm, Padmaja Sudhakar, Abdulnasser N Alhajeri, Jonathan H Smith
BACKGROUND: To date, no pathophysiologic model has sufficiently accounted for all the findings encountered in patients with idiopathic intracranial hypertension (IIH). Intracranial elastance is an index of volume-buffering capacity known to play a role in certain disorders of CSF dynamics, which has not been previously investigated in relation to IIH patients. METHODS: Single-center retrospective cohort study from July 1, 2011 to July 1, 2016. We collected values for opening pressure (PO ), closing pressure (PC ), volume (V) of CSF removed, as well as demographic and clinical covariates...
August 11, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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