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https://www.readbyqxmd.com/read/29131442/increased-rates-of-atrial-fibrillation-recurrence-following-pulmonary-vein-isolation-in-overweight-and-obese-patients
#1
Bhradeev Sivasambu, Muhammad A Balouch, Tarek Zghaib, Rizma J Bajwa, Jonathan Chrispin, Ronald D Berger, Hiroshi Ashikaga, Saman Nazarian, Joseph E Marine, Hugh Calkins, David D Spragg
INTRODUCTION: Catheter ablation is common for patients with symptomatic, drug-refractory atrial fibrillation (AF). Obesity is a known risk factor for incident AF. The impact of obesity on AF ablation outcomes is incompletely understood. We sought to determine the impact of elevated body mass index (BMI) on pulmonary vein isolation (PVI) procedural outcomes and associated complications. METHODS AND RESULTS: We evaluated patients undergoing PVI from 2001 to 2015, dividing them into four groups: normal weight (BMI ≥ 18...
November 13, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29128202/multi-hazard-risk-assessment-of-coastal-vulnerability-from-tropical-cyclones-a-gis-based-approach-for-the-odisha-coast
#2
Bishnupriya Sahoo, Prasad K Bhaskaran
The coastal region bordering the East coast of India is a thickly populated belt exposed to high risk and vulnerability from natural hazards such as tropical cyclones. Tropical cyclone frequencies that develop over the Bay of Bengal (average of 5-6 per year) region are much higher as compared to the Arabian Sea thereby posing a high risk factor associated with storm surge, inland inundation, wind gust, intense rainfall, etc. The Odisha State in the East coast of India experiences the highest number of cyclone strikes as compared to West Bengal, Andhra Pradesh, and Tamil Nadu...
November 8, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29126896/the-continuous-challenge-of-af-ablation-from-foci-to-rotational-activity
#3
REVIEW
Sanjiv M Narayan, Mohan N Vishwanathan, Christopher A B Kowalewski, Tina Baykaner, Miguel Rodrigo, Junaid A B Zaman, Paul J Wang
Pulmonary vein isolation (PVI) is central to ablation approaches for atrial fibrillation (AF), yet many patients still have arrhythmia recurrence after one or more procedures despite the latest technology for PVI. Ablation of rotational or focal sources for AF, which lie outside the pulmonary veins in many patients, is a practical approach that has been shown to improve success by many groups. Localized sources lie in atrial regions shown mechanistically to sustain AF in optical mapping and clinical studies of human AF, as well as computational and animal studies...
November 7, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29116663/higher-contact-force-energy-setting-and-impedance-rise-during-radiofrequency-ablation-predicts-charring-new-insights-from-contact-force-guided-in-vivo-ablation
#4
Hisaki Makimoto, Andreas Metzner, Roland Richard Tilz, Tina Lin, Christian-H Heeger, Andreas Rillig, Shibu Mathew, Christine Lemeš, Erik Wissner, Karl-Heinz Kuck, Feifan Ouyang
INTRODUCTION: Higher contact force (CF) theoretically increases the risk of blood charring, diminishing lesion formation. We aimed to investigate the relationship between CF, impedance change and char formation during pulmonary vein isolation (PVI). METHODS: CF was assessed during PVI in 65 patients. Radiofrequency ablation (RFA) with power-controlled mode was applied in the point-by-point manner. The RFA were divided into 5 groups: group-A [CF < 10 g], group-B (10 g≤CF < 20 g), group-C (20 g≤CF < 30 g), group-D (30 g≤CF < 40 g), and group-E (CF≥40 g)...
November 8, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29113716/plethysmography-variability-index-for-prediction-of-fluid-responsiveness-during-graded-haemorrhage-and-transfusion-in-sevoflurane-anaesthetized-mechanically-ventilated-dogs
#5
Yusuke Endo, Koudai Kawase, Taku Miyasho, Tadashi Sano, Kazuto Yamashita, William W Muir
OBJECTIVE: To examine the accuracy of plethysmography variability index (PVI) as a noninvasive indicator of fluid responsiveness in hypovolaemic dogs. STUDY DESIGN: Prospective experimental study. ANIMALS: Six adult healthy sevoflurane-anaesthetized Beagle dogs. METHODS: Dogs were anaesthetized with 1.3-fold their individual minimum alveolar concentration of sevoflurane. The lungs were mechanically ventilated after neuromuscular blockade with vecuronium bromide...
August 25, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29112729/single-freeze-per-vein-strategy-with-the-second-generation-cryoballoon-for-atrial-fibrillation-a-propensity-score-matched-study-between-180-and-240-s-application-time-in-a-large-cohort-of-patients
#6
Valentina De Regibus, Juan-Pablo Abugattas, Saverio Iacopino, Giacomo Mugnai, Cesare Storti, Giulio Conte, Angelo Auricchio, Erwin Ströker, Hugo-Enrique Coutiño, Ken Takarada, Francesca Salghetti, Ian Lusoc, Lucio Capulzini, Pedro Brugada, Carlo de Asmundis, Gian-Battista Chierchia
Aims: The single-freeze strategy using the second-generation cryoballoon (CB-A, Arctic Front Advance, Medtronic, Minneapolis, MN, USA) has been reported to be as effective as the recommended double-freeze approach in several single-centre studies. In this retrospective, international, multicentre study, we compare the 3-min single-freeze strategy with the 4-min single-freeze strategy. Methods and results: Four hundred and thirty-two patients having undergone pulmonary vein isolation (PVI) by means of CB-A using a single-freeze strategy were considered for this analysis...
November 2, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29107190/pulmonary-vein-isolation-cryoablation-for-persistent-and-long-standing-persistent-atrial-fibrillation-patients-clinical-outcomes-from-real-word-multicentric-observational-project
#7
Claudio Tondo, Saverio Iacopino, Paolo Pieragnoli, Giulio Molon, Roberto Verlato, Antonio Curnis, Maurizio Landolina, Giuseppe Allocca, Giuseppe Arena, Gaetano Fassini, Luigi Sciarra, Mario Luzi, Massimiliano Manfrin, Luigi Padeletti
BACKGROUND: Pulmonary vein isolation (PVI) is a cornerstone ablation strategy in the management of patients with atrial fibrillation (AF). Consensus guidelines and statements recommend PVI during the index catheter ablation procedure in patients with paroxysmal and persistent AF. OBJECTIVE: The objective of this analysis was to evaluate patients with persistent and long-standing persistent AF who were treated with the cryoballoon ablation catheter by PVI technique...
October 26, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29107175/entrapment-of-focal-atrial-tachycardia-using-cryoballoon-ablation-sinus-rhythm-in-the-left-atrium-and-ongoing-atrial-tachycardia-in-the-left-atrial-appendage
#8
Hikmet Yorgun, Uğur Canpolat, Banu Evranos, Kudret Aytemir
Left atrial appendage (LAA) is a well-known source of focal atrial tachycardias (AT). Although radio-frequency (RF) energy is the most commonly used technique in such cases, there was an option other than epicardial approach when RF technique fails. Cryoballoon technology is primarily developed to be used for pulmonary vein isolation (PVI). Also, there was no report regarding the isolation of LAA by using cryo-balloon in patients with focal AT. In this case, for the first time in the literature, we successfully isolated the LAA because of failed attempts of RF ablation for focal AT in whom the surface electrogram showed a sinus rhythm while arrhythmia continues inside the LAA...
October 28, 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29102650/safety-and-feasibility-of-atrial-fibrillation-ablation-using-amigo-%C3%A2-system-versus-manual-approach-a-pilot-study
#9
Antonio Scarà, Luigi Sciarra, Ermenegildo De Ruvo, Alessio Borrelli, Domenico Grieco, Zefferino Palamà, Paolo Golia, Lucia De Luca, Marco Rebecchi, Leonardo Calò
BACKGROUND: The Amigo(®) Remote Catheter System is a relatively new robotic system for catheter navigation. This study compared feasibility and safety using Amigo (RCM) versus manual catheter manipulation (MCM) to treat paroxysmal atrial fibrillation (PAF). Contact force (CF) and force-time integral (FTI) values obtained during pulmonary vein isolation (PVI) ablation were compared. METHODS: Forty patients were randomly selected for either RCM (20) or MCM (20). All were studied with the Thermocool(®) SmartTouch(®) force-sensing catheter (STc)...
November 1, 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29075979/second-generation-cryoballoon-ablation-for-persistent-atrial-fibrillation-an-updated-meta-analysis
#10
Hazem Omran, Klaus-Jürgen Gutleben, Stephan Molatta, Thomas Fischbach, Birgit Wellmann, Dieter Horstkotte, Britta Körber, Georg Nölker
BACKGROUND: Catheter ablation is an established treatment option for patients with symptomatic atrial fibrillation (AF). The cornerstone of AF ablation is pulmonary vein isolation (PVI). The second-generation cryoballoon (2G-CB) has shown non-inferiority to radiofrequency (RF) ablation in paroxysmal AF in several trials. Growing evidence suggests that 2G-CB is also effective in patients with persistent AF (perAF). The aim of this study was to summarize and analyze available data on safety and mid-term (≥ 12 months) efficacy of PVI using 2G-CB in patients with perAF...
October 26, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29075201/virtual-in-silico-modeling-guided-catheter-ablation-predicts-effective-linear-ablation-lesion-set-for-longstanding-persistent-atrial-fibrillation-multicenter-prospective-randomized-study
#11
Jaemin Shim, Minki Hwang, Jun-Seop Song, Byounghyun Lim, Tae-Hoon Kim, Boyoung Joung, Sung-Hwan Kim, Yong-Seog Oh, Gi-Byung Nam, Young Keun On, Seil Oh, Young-Hoon Kim, Hui-Nam Pak
Objective: Radiofrequency catheter ablation for persistent atrial fibrillation (PeAF) still has a substantial recurrence rate. This study aims to investigate whether an AF ablation lesion set chosen using in-silico ablation (V-ABL) is clinically feasible and more effective than an empirically chosen ablation lesion set (Em-ABL) in patients with PeAF. Methods: We prospectively included 108 patients with antiarrhythmic drug-resistant PeAF (77.8% men, age 60.8 ± 9.9 years), and randomly assigned them to the V-ABL (n = 53) and Em-ABL (n = 55) groups...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29070619/circular-mapping-catheter-entrapment-in-mitral-valve-apparatus-requiring-emergency-surgery-a-rarely-reported-complication-of-pulmonary-vein-isolation-procedure-for-atrial-fibrillation
#12
Muhammad Iftikhar Sabar, Abhay Bajpai, Aziz Momin, Riyaz A Kaba
Lasso catheter (Biosense Webster) is one of the most commonly employed circular mapping catheters during pulmonary vein isolation (PVI) procedure for atrial fibrillation (AF). Although this catheter has greatly facilitated arrhythmia mapping, it can be associated with serious complications. We report a case of a 59-year-old man who underwent PVI procedure for persistent AF. During the procedure, the Lasso catheter inadvertently slipped into the left ventricular cavity and entangled in the mitral valve apparatus...
October 25, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29069523/uncoupling-effect-of-f16-is-responsible-for-its-mitochondrial-toxicity-and-anti-cancer-activity
#13
Jia Wang, Huan He, Chen Xiang, Xiao- Yang Fan, Li-Yun Yang, Lian Yuan, Feng-Lei Jiang, Yi Liu
As a novel delocalized lipophilic cation (DLC), F16 selectively accumulates in mitochondria of carcinoma cells and shows a broad spectrum of antiproliferative action towards cancer cell lines. In order to reveal the mode of action and molecular mechanism of F16 inducing cytotoxicity, we investigated the effects of F16 on cancer cells and isolated mitochondria relative to its precursor compound PVI, which has a similar structure without positive charge. It was found that PVI did not accumulate in mitochondria, and exhibited lower cytotoxicity compared to F16...
October 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29056956/clinical-outcomes-of-radiofrequency-catheter-ablation-of-atrial-fibrillation-in-octogenarians-10-year-experience-of-a-one-high-volume-center
#14
Alan Bulava, Jiri Hanis, Ladislav Dusek
BACKGROUND: Prevalence of atrial fibrillation (AF) increases with age. Radiofrequency catheter ablation (RFCA) is an established treatment option superior to antiarrhythmics (AAs). In this study, we investigated safety and efficacy of RFCA of AF in octogenarians. METHODS: From our database, we extracted procedural and follow-up data for patients ≥ 80 years with symptomatic AF undergoing RFCA and compared this population to RFCA patients ≤ 50 years. All patients underwent pulmonary vein isolation (PVI) supplemented by linear lesions in PVI-nonresponders...
September 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29049809/association-of-quality-improvement-registry-participation-with-appropriate-follow-up-after-vascular-procedures
#15
Benjamin S Brooke, Adam W Beck, Larry W Kraiss, Andrew W Hoel, Andrea M Austin, Amir A Ghaffarian, Jack L Cronenwett, Philip P Goodney
Importance: Ensuring that patients undergo surveillance imaging after surgery is a key quality metric after many vascular procedures. It is unclear whether hospital participation in a national quality improvement registry such as the Vascular Quality Initiative (VQI) achieves this goal. Objective: To determine if hospital participation in the VQI registry is associated with increased rates of surveillance imaging after vascular procedures. Design, Setting, and Participants: A quasi-experimental study used Medicare claims to study 2174 US hospitals in which 1 530 102 patients had undergone an endovascular abdominal aortic aneurysm repair (EVAR), 1 403 067 patients had undergone a lower extremity bypass (LEB) or peripheral vascular intervention (PVI), and 294 942 patients had undergone carotid endarterectomy (CEA) and carotid artery stenting (CAS) procedures between January 1, 2007, and December 31, 2012...
October 11, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29039531/prognostic-implications-and-procoagulant-activity-of-phosphatidylserine-exposure-of-blood-cells-and-microparticles-in-patients-with-atrial-fibrillation-treated-with-pulmonary-vein-isolation
#16
Huan Meng, Junjie Kou, Ruishuang Ma, Wenbo Ding, Yan Kou, Muhua Cao, Zengxiang Dong, Yayan Bi, Hemant S Thatte, Jialan Shi
The present study aimed to evaluate the procoagulant effects of phosphatidylserine (PS) exposure on blood cells and microparticles (MPs), and examine its role in predicting early recurrence atrial fibrillation (ERAF) in patients with atrial fibrillation (AF) treated with pulmonary vein isolation (PVI). Blood samples were obtained from 40 healthy controls and 56 patients with AF at baseline (prior to PVI), and 0, 1 h, 1 day, 3 days and 7 days following PVI. The exposure of PS (PS+) to blood cells (platelets, erythrocytes and leukocytes) and MPs was detected using flow cytometry...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29024713/a-lack-of-glun2a-containing-nmda-receptors-confers-a-vulnerability-to-redox-dysregulation-consequences-on-parvalbumin-interneurons-and-their-perineuronal-nets
#17
Romain Cardis, Jan-Harry Cabungcal, Daniella Dwir, Kim Q Do, Pascal Steullet
The GluN2A subunit of NMDA receptors (NMDARs) plays a critical role during postnatal brain development as its expression increases while Glun2B expression decreases. Mutations and polymorphisms in GRIN2A gene, coding for GluN2A, are linked to developmental brain disorders such as mental retardation, epilepsy, schizophrenia. Published data suggest that GluN2A is involved in maturation and phenotypic maintenance of parvalbumin interneurons (PVIs), and these interneurons suffer from a deficient glutamatergic neurotransmission via GluN2A-containing NMDARs in schizophrenia...
October 10, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29016870/complications-of-pulmonary-vein-isolation-in-atrial-fibrillation-predictors-and-comparison-between-four-different-ablation-techniques-results-from-the-middelheim-pvi-registry
#18
Yves De Greef, Edwin Ströker, Bruno Schwagten, Kaspars Kupics, Jeroen De Cocker, Gian-Battista Chierchia, Carlo de Asmundis, Dirk Stockman, Ian Buysschaert
Aims: To define predictors of complications of pulmonary vein isolation (PVI) and compare safety between different ablation techniques. Methods and results: One thousand patients with atrial fibrillation (AF) (age 60 ± 10, 72% males, CHA2DS2-VASc score 1 ± 1) underwent PVI using various techniques: conventional PVI (CPVI) using mapping with irrigated point-per-point RF ablation (n = 576), multi-electrode RF ablation with the pulmonary vein ablation catheter (PVAC) (n = 272) or high density mesh ablator (HDMA) (n = 59) and cryoballoon (CB) ablation (n = 93)...
August 3, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29016779/is-less-more-impact-of-different-ablation-protocols-on-periprocedural-complications-in-second-generation-cryoballoon-based-pulmonary-vein-isolation
#19
Laura Rottner, Thomas Fink, Christian-Hendrik Heeger, Michael Schlüter, Britta Goldmann, Christine Lemes, Tilman Maurer, Bruno Reißmann, Enida Rexha, Johannes Riedl, Francesco Santoro, Peter Wohlmuth, Shibu Mathew, Christian Sohns, Feifan Ouyang, Karl-Heinz Kuck, Andreas Metzner
Aims: Second-generation cryoballoon (CB2) based pulmonary vein isolation (PVI) has emerged as an effective treatment option for symptomatic atrial fibrillation (AF). The current study sought to assess the impact of different ablation protocols on the incidence and characteristics of procedural complications in a large patient cohort. Methods and results: A total of 563 consecutive patients with symptomatic AF who underwent CB2-based ablation between July 2012 and January 2016, were assessed...
July 24, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29016770/development-and-validation-of-a-risk-score-for-predicting-atrial-fibrillation-recurrence-after-a-first-catheter-ablation-procedure-atlas-score
#20
João Mesquita, António Miguel Ferreira, Diogo Cavaco, Francisco Moscoso Costa, Pedro Carmo, Hugo Marques, Francisco Morgado, Miguel Mendes, Pedro Adragão
Aims: Several predictors of relapse after catheter ablation of atrial fibrillation (AF) have been established, but assessing each patient's individual risk remains challenging. Our aim was to develop and validate a score to estimate the risk of AF recurrence after the first radiofrequency pulmonary vein isolation (PVI) procedure. Methods and results: Independent predictors of AF relapse were identified retrospectively in a two-centre registry of 1934 patients who underwent a first PVI procedure...
August 18, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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