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https://www.readbyqxmd.com/read/28340103/diagnosis-to-ablation-time-as-a-predictor-of-success-early-choice-for-pulmonary-vein-isolation-and-long-term-outcome-in-atrial-fibrillation-results-from-the-middelheim-pvi-registry
#1
Y De Greef, B Schwagten, G B Chierchia, C de Asmundis, D Stockman, I Buysschaert
Aims: The aim of the study is to define long-term outcome of pulmonary vein isolation (PVI) in atrial fibrillation (AF) and to determine whether time window between AF diagnosis and PVI affects outcome. Methods and results: Consecutive AF patients undergoing PVI (2006-14) were followed for 5 years. Primary outcome was clinical success, defined as freedom of documented AF without anti-arrhythmic drugs respecting a 1-month blanking period. A 1000 patients were included (age 60 ± 10 years, CHA2DS2-VASc score 1 ± 1)...
March 2, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28340073/left-atrial-appendage-isolation-in-addition-to-pulmonary-vein-isolation-in-persistent-atrial-fibrillation-one-year-clinical-outcome-after-cryoballoon-based-ablation
#2
Hikmet Yorgun, Ugur Canpolat, Duygu Kocyigit, Cem Çöteli, Banu Evranos, Kudret Aytemir
Aims: In this study, we sought to evaluate the safety and efficacy of cryoballoon (CB) based empirical left atrial appendage (LAA) isolation as an adjunct to pulmonary vein isolation (PVI) compared to the PVI-only strategy in patients with persistent AF. Objectives: Clinical outcomes of catheter ablation were less beneficial for persistent atrial fibrillation (AF) than paroxysmal AF. Methods and results: A total of 100 consecutive patients with persistent AF underwent both PVI and additional LAA isolation using CB (Group II)...
March 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339546/multicentre-safety-of-adding-focal-impulse-and-rotor-modulation-firm-to-conventional-ablation-for-atrial-fibrillation
#3
David E Krummen, Tina Baykaner, Amir A Schricker, Christopher A B Kowalewski, Vijay Swarup, John M Miller, Gery F Tomassoni, Shirley Park, Mohan N Viswanathan, Paul J Wang, Sanjiv M Narayan
Aims: Focal Impulse and Rotor Modulation (FIRM) uses 64-electrode basket catheters to identify atrial fibrillation (AF)-sustaining sites for ablation, with promising results in many studies. Accordingly, new basket designs are being tested by several groups. We set out to determine the procedural safety of adding basket mapping and map-guided ablation to conventional pulmonary vein isolation (PVI). Methods and results: We collected 30 day procedural safety data in five US centres for consecutive patients undergoing FIRM plus PVI (FIRM-PVI) compared with contemporaneous controls undergoing PVI without FIRM...
December 22, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28324324/prognostic-factors-of-sorafenib-therapy-in-hepatocellular-carcinoma-patients-with-failure-of-transarterial-chemoembolization
#4
Sangheun Lee, Jung Hyun Kang, Do Young Kim, Sang Hoon Ahn, Jun Yong Park, Beom Kyung Kim, Seung Up Kim, Kwang-Hyub Han
BACKGROUND: There is no approved therapy for patients with failed transarterial chemoembolization (TACE) and progression of hepatocellular carcinoma. We aimed to investigate the efficacy and prognostic factors in patients with TACE failure who received sorafenib rescue therapy. METHODS: We investigated 54 patients who met the criteria of TACE failure as defined by the international guidelines of Europe and Japan. Sorafenib was used as a rescue therapy. Overall survival (OS) and progression-free survival (PFS) were analyzed by Kaplan-Meier methods, and multivariate analysis was performed to find prognostic factors...
March 21, 2017: Hepatology International
https://www.readbyqxmd.com/read/28322275/oxidative-stress-driven-parvalbumin-interneuron-impairment-as-a-common-mechanism-in-models-of-schizophrenia
#5
P Steullet, J-H Cabungcal, J Coyle, M Didriksen, K Gill, A A Grace, T K Hensch, A-S LaMantia, L Lindemann, T M Maynard, U Meyer, H Morishita, P O'Donnell, M Puhl, M Cuenod, K Q Do
Parvalbumin inhibitory interneurons (PVIs) are crucial for maintaining proper excitatory/inhibitory balance and high-frequency neuronal synchronization. Their activity supports critical developmental trajectories, sensory and cognitive processing, and social behavior. Despite heterogeneity in the etiology across schizophrenia and autism spectrum disorder, PVI circuits are altered in these psychiatric disorders. Identifying mechanism(s) underlying PVI deficits is essential to establish treatments targeting in particular cognition...
March 21, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28321025/one-year-success-rate-of-pulmonary-vein-isolation-using-a-novel-irrigated-multipolar-mapping-and-ablation-catheter-with-reduced-power-settings
#6
Dong-In Shin, Jan-Erik Guelker, Christian Blockhaus, Jan Schmidt, Muhammed Kurt, Lukas Clasen, Patrick Mueller, Lars Bansemir, Christoph Brinkmeyer, Alexander Bufe, Malte Kelm, Hisaki Makimoto
The use of a novel irrigated multipolar ablation and mapping catheter for pulmonary vein isolation in patients with atrial fibrillation (AF) has demonstrated reasonable acute success rates and short procedure times, however, long-term outcome data are limited. The aim of this study was to analyze the long-term efficacy of this novel ablation system utilizing a reduced power setting for safety purposes.A total of 89 patients with paroxysmal (63 of 89 patients; 71%) or persistent AF underwent PVI with a reduced power setting of maximum 20 Watts (W) unipolar radiofrequency energy and 30 seconds in duration...
March 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28316148/ablation-of-complex-fractionated-electrograms-with-or-without-additional-linear-lesions-for-persistent-atrial-fibrillation-the-adline-trial
#7
Sonia Ammar-Busch, Felix Bourier, Tilko Reents, Verena Semmler, Marta Telishevska, Susanne Kathan, Monika Hofmann, Gabriele Hessling, Isabel Deisenhofer
BACKGROUND: For persistent atrial fibrillation (AF) ablation, different strategies including complex fractionated atrial electrograms (CFAE) ablation and linear lesions (LL) have been used in addition to pulmonary vein isolation (PVI). However, it is still a matter of debate if extended substrate modification improves long-term outcome. The aim of this study was to determine the benefit of LL in addition to PVI and CFAE ablation regarding freedom from arrhythmia recurrence in patients with persistent AF...
March 18, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28306170/impact-of-atrial-fibrillation-on-platelet-gene-expression
#8
Waldemar E Wysokinski, Alfonso Tafur, Naser Ammash, Samuel J Asirvatham, Yanhong Wu, Izabella Gosk-Bierska, Diane E Grill, Joshua P Slusser, Jozef Mruk, Robert D McBane
AIMS: Platelets retain cytoplasmic messenger RNA and are capable of protein biosynthesis. Several diseases are known to impact the platelet transcriptome but the effect of non-valvular atrial fibrillation (NVAF) on platelet RNA transcript is essentially unknown. The aim of this study was to evaluate the impact of NVAF on platelet RNA transcript by measuring platelet genes expression in consecutive NVAF patients before and 3-4 months after pulmonary vein isolation (PVI) and compared to normal sinus rhythm controls (NSR)...
March 17, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28291903/prostate-volume-index-stratified-prostate-cancer-risk-in-patients-elected-to-a-first-random-biopsy-set
#9
Antonio B Porcaro, Paolo Corsi, Nicolò de Luyk, Marco Sebben, Alessandro Tafuri, Leonardo Bizzotto, Giovanni Cacciamani, Davide De Marchi, Tania Processali, Daniele Mattevi, Giovanni Novella, Maria A Cerruto, Matteo Brunelli, Salvatore Siracusano, Walter Artibani
OBJECTIVE: To investigate prostate volume index (PVI), defined as the ratio of volume of the transitional zone on that of the peripheral zone, as a factor stratifying prostate cancer (PCA) risk in patients elected to a first random biopsy set. METHODS: The study evaluated 596 patients who were elected to a first random biopsy set because of suspected PCA in a period between September 2010 and September 2015. Prostate volume index was dichotomized to PVI ≤1 vs PVI >1...
February 28, 2017: Tumori
https://www.readbyqxmd.com/read/28285383/adenosine-administration-during-hybrid-atrial-fibrillation-ablation-to-test-dormant-pulmonary-vein-conduction
#10
Mindy Vroomen, Mark La Meir, Jos G Maessen, Harry J Crijns, Laurent Pison
BACKGROUND: Adenosine administration after initial pulmonary vein isolation (PVI) reveals dormant conduction and predicts atrial fibrillation (AF) recurrence. Elimination of dormant conduction when present may increase a long-term success rate of AF ablation procedures. There are no studies till date using adenosine to reveal acute reconduction of pulmonary veins (PVs) after epicardial PVI during a hybrid AF ablation procedure. METHODS: We included 24 patients (21 male, 55 ± 9 years) undergoing hybrid ablation for symptomatic paroxysmal (n = 12) and persistent (n = 12) AF, using an epicardial bipolar radiofrequency clamp to perform PVI...
March 11, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28283860/long-term-outcome-after-second-generation-cryoballoon-ablation-for-paroxysmal-atrial-fibrillation-a-3-years-follow-up
#11
Ken Takarada, Ingrid Overeinder, Carlo de Asmundis, Erwin Stroker, Giacomo Mugnai, Valentina de Regibus, Darragh Moran, Hugo Coutino-Moreno, Juan-Pablo Abugattas, Rajin Choudhury, Diego Ruggiero, Gaetano Paparella, Saverio Iacopino, Pedro Brugada, Gian-Battista Chierchia
BACKGROUND: The second-generation cryoballoon (cryoballoon Advance; CB-A) offers excellent outcomes on the mid-term follow-up. To the best of our knowledge, little is known regarding the long-term outcome after CB-A ablation for paroxysmal atrial fibrillation (AF). OBJECTIVE: The aim of the study was to evaluate the freedom from recurrence of AF during a 3-year follow-up period, among consecutive patients having undergone pulmonary vein isolation (PVI) with the CB-A for paroxysmal AF (PAF)...
March 10, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28283782/prostate-transitional-zone-volume-based-nomogram-for-predicting-prostate-cancer-and-high-progression-prostate-cancer-in-a-real-world-population
#12
Yanqing Wang, Shaowei Xie, Xun Shangguan, Jiahua Pan, Yinjie Zhu, Zhixiang Xin, Fan Xu, Xiaoguang Shao, Liancheng Fan, Jianjun Sha, Qiang Liu, Baijun Dong, Wei Xue
PURPOSE: To evaluate and compare the efficacy of prostate volume (PV), transitional zone volume (TZV), and prostate volume index (PVI, the ratio of TZV to peripheral zone volume) in the identification of men at risk of prostate cancer (PCa) and high-progression PCa (HPPCa) at the initial biopsy (IBX) in a real-world population. METHODS: From Jul 2014 to Aug 2016, data on 1144 patients who had undergone the initial prostate biopsies were prospectively collected and analyzed...
March 10, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28281739/cerebral-micro-embolization-during-pulmonary-vein-isolation-relation-to-post-ablation-silent-cerebral-ischemia
#13
Edina Nagy-Baló, Mihran Martirosyan, Gábor Sándorfi, Orsolya Hajas, Levente Lánczi, Ervin Berényi, Lilla Ladányi, Alexandra Kiss, István Édes, Zoltán Csanádi
BACKGROUND: High incidences of silent cerebral ischemia (SCI) have been revealed by diffusion-weighted magnetic resonance imaging (DW MRI) after pulmonary vein isolation (PVI) for atrial fibrillation. A high number of mostly gaseous micro-embolic signals (MESs) was detected by transcranial Doppler (TCD) during PVI. In this investigation the possible relationship between MESs detected intraoperatively by TCD and new SCI on DW MRI post-ablation is reported. METHODS: 27 consecutive atrial fibrillation patients (6 female, age median: 64 interquartile range: 13...
March 10, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28279869/vapor-intrusion-risk-of-fuel-ether-oxygenates-methyl-tert-butyl-ether-mtbe-tert-amyl-methyl-ether-tame-and-ethyl-tert-butyl-ether-etbe-a-modeling-study
#14
Jie Ma, Desen Xiong, Haiyan Li, Yi Ding, Xiangcheng Xia, Yongqi Yang
Vapor intrusion of synthetic fuel additives represents a critical yet still neglected problem at sites contaminated by petroleum fuel releases. This study used an advanced numerical model to investigate the vapor intrusion potential of fuel ether oxygenates methyl tert-butyl ether (MTBE), tert-amyl methyl ether (TAME), and ethyl tert-butyl ether (ETBE). Simulated indoor air concentration of these compounds can exceed USEPA indoor air screening level for MTBE (110μg/m(3)). Our results also reveal that MTBE has much higher chance to cause vapor intrusion problems than TAME and ETBE...
February 28, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28260190/general-anesthesia-improves-contact-force-and-reduces-gap-formation-in-pulmonary-vein-isolation-a-comparison-with-conscious-sedation
#15
Akio Chikata, Takeshi Kato, Takanori Yaegashi, Satoru Sakagami, Chieko Kato, Takahiro Saeki, Keiichi Kawai, Shin-Ichiro Takashima, Hisayoshi Murai, Soichiro Usui, Hiroshi Furusho, Shuichi Kaneko, Masayuki Takamura
Compared to conscious sedation (CS), the use of general anesthesia (GA) in pulmonary vein isolation (PVI) is associated with a lower recurrence rate of atrial fibrillation (AF). GA may improve catheter stability and mapping system accuracy compared to CS, but its influence on contact force (CF) parameters during ipsilateral PVI has not previously been investigated. The study population comprised 176 consecutive patients (107 in GA group and 69 in CS group) with AF who underwent their first PVI procedure. We retrospectively assessed CF parameters, force-time integral (FTI), FTI/wall thickness during anatomical ipsilateral PVI and long-term outcome after ablation...
March 4, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28259694/techniques-for-provocation-localization-and-ablation-of-nonpulmonary-vein-triggers-for-atrial-fibrillation
#16
Pasquale Santangeli, Francis E Marchlinski
The endpoint of current catheter-based ablation approaches for the treatment of atrial fibrillation (AF) is the elimination of all the possible triggers with the least amount of ablation necessary. Once all the triggers have been eliminated, the incremental value of any additional lesion sets remains to be proven. Pulmonary vein isolation (PVI) is the cornerstone of catheter ablation approaches for eliminating AF triggers. However, up to 11% of patients demonstrate reproducible sustained AF initiation from non-PV foci...
March 1, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28258054/thrombophilia-risk-is-not-increased-in-children-after-perinatal-stroke
#17
Colleen Curtis, Aleksandra Mineyko, Patricia Massicotte, Michael Leaker, Xiu Yan Jiang, Amalia Floer, Adam Kirton
Perinatal stroke causes cerebral palsy and lifelong disability. Specific diseases are definable but mechanisms are poorly understood. Evidence suggests possible associations between arterial perinatal stroke and prothrombotic disorders but population-based, controlled, disease-specific studies are limited. Understanding thrombophilia in perinatal stroke informs pathogenesis models and clinical management. We conducted a population-based, prospective, case-control study to determine the association of specific perinatal stroke diseases with known thrombophilias...
March 3, 2017: Blood
https://www.readbyqxmd.com/read/28256178/adjunctive-ablation-strategies-improve-the-efficacy-of-pulmonary-vein-isolation-in-non-paroxysmal-atrial-fibrillation-a-systematic-review-and-meta-analysis
#18
REVIEW
Muhammad R Afzal, Anweshan Samanta, Jawaria Chatta, Brihh Ansari, Sam Atherton, Syed Sabzwari, Mohit Turagam, Dhanunjaya Lakkireddy, Mahmoud Houmsse
BACKGROUND: Pulmonary vein (PV) isolation (PVI) has suboptimal outcomes in patients with non-paroxysmal atrial fibrillation (AF). Adjunctive strategies employed to ablate non-PV triggers have shown favorable outcomes. AIMS: To delineate the incremental benefit of adjunctive ablation in patients with non-paroxysmal AF through a meta-analysis. METHODS AND RESULTS: Database searches through August 2016 identified five non-randomized and seven randomized controlled trials (enrolling 1694 patients)...
March 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28251658/catheter-ablation-of-recurrent-paroxysmal-atrial-fibrillation-is-gap-closure-combining-ganglionated-plexi-ablation-more-effective
#19
Feng-Qiang Xu, Rong-Hui Yu, Jun-Jie Guo, Rong Bai, Nian Liu, Y I An, Xue-Yuan Guo, Ri-Bo Tang, DE-Yong Long, Cai-Hua Sang, Xin DU, Jian-Zeng Dong, Chang-Sheng Ma
BACKGROUND: For repeat treatment with PAF (paroxysmal atrial fibrillation) recurrence, gap-closure at pulmonary vein ostia alone is not enough. Many recent studies indicated that GPs (ganglionated plexi) denervation could reduce the recurrence of AF. However it is unclear whether the clinical outcomes of additional GP ablation plus PVs (pulmonary veins) reisolation during a repeat procedure were associated with less recurrence in PAF patients. The purpose of this study was to evaluate if a repeat procedure of GPA (Ganglionated Plexi Ablation) combining re-PVI (repeated procedure of pulmonary vein isolation, i...
March 2, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28245798/left-atrial-appendage-morphology-and-risk-of-stroke-following-pulmonary-vein-isolation-for-drug-refractory-atrial-fibrillation-in-low-cha2ds2vasc-risk-patients
#20
Faith R Kelly, Robert A Hull, Takor B Arrey-Mbi, Michael U Williams, Joshua S Lee, Ahmad M Slim, Dustin M Thomas
BACKGROUND: Cardiac CT angiography (CCTA) has become an important adjunct in the structural assessment of the pulmonary veins (PV) prior to pulmonary vein isolation (PVI). Published data is conflicting regarding a relationship between left atrial appendage (LAA) and the risk of ischemic stroke (CVA) following PVI. We investigated the associations of volumetric and morphologic left atrial (LA) and LAA measurements for CVA following PVI. METHODS: We retrospectively reviewed 332 consecutive patients with drug refractory atrial fibrillation who obtained cardiac CT angiogram (CCTA) prior to PVI...
February 28, 2017: BMC Cardiovascular Disorders
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