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https://www.readbyqxmd.com/read/28231275/suppression-of-tgf-%C3%AE-pathway-by-pirfenidone-decreases-extracellular-matrix-deposition-in-ocular-fibroblasts-in-vitro
#1
Thomas Stahnke, Bhavani S Kowtharapu, Oliver Stachs, Klaus-Peter Schmitz, Johannes Wurm, Andreas Wree, Rudolf Friedrich Guthoff, Marina Hovakimyan
In glaucoma surgery, fibrotic processes occur, leading to impairment of liquid outflow. Activated fibroblasts are responsible for postoperative scarring. The transforming growth factor-β (TGF-β) pathway plays a key role in fibroblast function, differentiation and proliferation. The aim of this study was the characterization of the fibrotic potential of two subtypes of primary human ocular fibroblasts and the attempt to inhibit fibrotic processes specifically, without impairing cell viability. For fibrosis inhibition we focused on the small molecule pirfenidone, which has been shown to prevent pulmonary fibrosis by the decrease of the expression of TGF-β1, TGF-β2 and TGF-β3 cytokines...
2017: PloS One
https://www.readbyqxmd.com/read/28223014/calculation-of-resected-orbital-wall-areas-in-the-treatment-of-endocrine-orbitopathy
#2
Matthias Krause, Heike Hümpfner-Hierl, Daniel Kruber, Ina Sterker, Thomas Hierl
PURPOSE: Orbital wall decompression is routinely used to treat proptosis in endocrine orbitopathy. Until now, however, there has been no investigation to measure the area/extent of the removed walls. MATERIALS AND METHODS: The inner areas of 154 orbital walls (lateral, inferior, medial) which had been resected in 38 patients were measured using pre- and postsurgical computed tomographic data in Brainlab iPlan software. Furthermore the effect of concomitant centrolateral orbital rim advancement was calculated in 48 cases...
January 25, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28221296/long-term-outcomes-of-eye-sparing-surgery-for-adenoid-cystic-carcinoma-of-lacrimal-gland
#3
Jisang Han, Yoon-Duck Kim, Kyung In Woo, Deepak Sobti
PURPOSE: This study's primary purpose is to assess the long-term outcomes of patients who have undergone eye-sparing surgery and adjuvant radiotherapy for adenoid cystic carcinoma of the lacrimal gland. METHODS: In this retrospective analysis, clinical records were reviewed of all patients diagnosed with adenoid cystic carcinoma of the lacrimal gland, at a single institution, between March 1998 and November 2012. Ten patients were identified as having undergone eye-sparing surgery and adjuvant radiotherapy for adenoid cystic carcinoma of the lacrimal gland...
February 17, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28221293/orbital-emphysema-as-a-rare-complication-of-retina-surgery
#4
Lourdes Rodríguez-Cabrera, José L Rodríguez-Loaiza, José L Tovilla-Canales, Francisca Zuazo
Three patients with a history of previous pars-plana vitrectomy, 2 of them with perfluoropropane, and 1 with sulfur hexafluoride used, experienced eyelid swelling and pain after travelling to a higher altitude city. Gas was found in the orbit and periocular tissues, causing orbital compartment syndrome in 2 of the patients. The gas persisted on these patients despite surgical intervention, so hyperbaric oxygen therapy was advised. One patient refused, the other patient responded well to this therapy and the gas disappeared...
February 17, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28216937/renal-cell-carcinoma-atypical-metastasis-to-inguinal-lymph-nodes
#5
Qamar Saeed Chaudhry, Tanweer Ahmed Naveed Bhatty, Ziauddin Khan, Elsawi Medani Osman
Renal cell carcinoma (RCC) is a common tumor of the urinary tract. It is known to have variable presentations due to the extremely vascular nature of the organ. RCC are known to metastasize to lungs, bone, and brain commonly but atypical metastasis to various sites are reported in literature but as very rare pathology. We report a case of a 60-year-old female who presented with multiple inguinal and axillary lymph node enlargements which on excision biopsy showed metastatic RCC. RCC can present with synchronous metastatic deposits in the various organs...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28210413/orbital-adherence-syndrome-following-the-use-of-titanium-precontoured-orbital-mesh-for-the-reconstruction-of-posttraumatic-orbital-floor-defects
#6
Geraldine Hwee Ping Lee, Samuel Yew Ming Ho
Orbital blowout fractures are a common occurrence following orbital trauma. Depending on the size of the defect and the contents that have herniated or incarcerated, possible sequelae include enophthalmos, diplopia, dystopia, and entrapment. Surgical intervention aims to prevent or alleviate this through the use of a bone graft or an alloplastic implant to reconstitute the continuity of the orbit. However, in doing so, the implant itself may result in the unexpected adherence of the periorbita, resulting in orbital adherence syndrome...
March 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/28210406/use-of-c-arm-to-assess-reduction-of-zygomatic-complex-fractures-a-comparative-study
#7
Atmakuru Venkata Maheedhar, C Ravindran, Emmanuel D S Azariah
The aim of this study was to analyze the use of C-arm and its significance in accurate reduction of zygomaticomaxillary complex (ZMC) fractures. Orbital volume is used as parameter to compared pre- and postoperative volumes of injured orbit. Differences in orbital volume calculated in cases done with intraoperative imaging and in controls treated without the use of intraoperative imaging were evaluated using Student t-test. C-arm is definitively an effective tool in the armamentarium of oral and maxillofacial surgery in assessment of reduction of ZMC fracture...
March 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/28210404/infraorbital-nerve-decompression-for-infraorbital-neuralgia-causalgia-following-blowout-orbital-fractures-a-case-series
#8
Bijan Beigi, Mazda Beigi, Nuwan Niyadurupola, Manuel Saldana, Nabil El-Hindy, Deepak Gupta
The purpose of this study was to present the management of a series of patients referred with infraorbital nerve paraesthesia that developed after insignificant orbital floor fracture without diplopia or exophthalmos, and that did not require initial surgical repair. This is a retrospective interventional case series. The main outcome and measures were assessment of preoperative symptoms including neuralgia and sensory symptoms; review of periorbital computed tomography (CT) scans; and assessment of postoperative effects of surgery for infraorbital nerve decompression...
March 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/28210402/interdisciplinary-management-of-minimally-displaced-orbital-roof-fractures-delayed-pulsatile-exophthalmos-and-orbital-encephalocele
#9
Austin Y Ha, William Mangham, Sarah A Frommer, David Choi, Petra Klinge, Helena O Taylor, Adetokunbo A Oyelese, Stephen R Sullivan
Traumatic orbital roof fractures are rare and are managed nonoperatively in most cases. They are typically associated with severe mechanisms of injury and may be associated with significant neurologic or ophthalmologic compromise including traumatic brain injury and vision loss. Rarely, traumatic encephalocele or pulsatile exophthalmos may be present at the time of injury or develop in delayed fashion, necessitating close observation of these patients. In this article, we describe two patients with minimally displaced blow-in type orbital roof fractures that were later complicated by orbital encephalocele and pulsatile exophthalmos, prompting urgent surgical intervention...
March 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/28210177/orbital-reconstruction-with-a-partially-absorbable-mesh-monofilament-polypropylene-fibre-and-monofilament-poliglecaprone-25-our-experience-with-34-patients
#10
Moustafa Alkhalil, J Joshi Otero
PURPOSE: To evaluate the effectiveness and complications related to the use of a partially absorbable mesh for the reconstruction of orbital floor fractures. This is a retrospective review of 34 consecutive patients who suffered orbital trauma from August 2007 to March 2013 treated with a partially absorbable mesh for orbital reconstruction. Data collected included gender, age, nationality, cause of injury, date of admission, date of surgery, date of discharge, type of fracture, signs and symptoms such as diplopia, enophthalmos, and sensory disturbance related to the infraorbital nerve, complications before and after surgery, and follow-ups at 1 week, 1 month, 6 months, and after 1 year...
July 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28202996/-surgical-reconstruction-of-maxillary-defects-using-a-computer-assisted-techniques
#11
W B Zhang, Y Yu, Y Wang, X J Liu, C Mao, C B Guo, G Y Yu, X Peng
The maxilla is the most important bony support of the mid-face skeleton and is critical for both esthetics and function. Maxillary defects, resulting from tumor resection, can cause severe functional and cosmetic deformities. Furthermore, maxillary reconstruction presents a great challenge for oral and maxillofacial surgeons. Nowadays, vascularized composite bone flap transfer has been widely used for functional maxillary reconstruction. In the last decade, we have performed a comprehensive research on functional maxillary reconstruction with free fibula flap and reported excellent functional and acceptable esthetic results...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28202368/the-use-of-virtual-surgical-planning-and-navigation-in-the-treatment-of-orbital-trauma
#12
Alan Scott Herford, Meagan Miller, Floriana Lauritano, Gabriele Cervino, Fabrizio Signorino, Carlo Maiorana
Virtual surgical planning (VSP) has recently been introduced in craniomaxillofacial surgery with the goal of improving efficiency and precision for complex surgical operations. Among many indications, VSP can also be applied for the treatment of congenital and acquired craniofacial defects, including orbital fractures. VSP permits the surgeon to visualize the complex anatomy of craniofacial region, showing the relationship between bone and neurovascular structures. It can be used to design and print using three-dimensional (3D) printing technology and customized surgical models...
January 21, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28195890/medial-orbital-wall-reconstruction-with-porous-polyethylene-by-using-a-transconjunctival-approach-with-a-caruncular-extension
#13
Chieh Chou, Yur-Ren Kuo, Chien-Chang Chen, Cheng-Sheng Lai, Sin-Daw Lin, Shu-Hung Huang, Su-Shin Lee
BACKGROUND: The reported rate of isolated medial orbital wall fractures varies widely but has been found to be as high as 55% of all orbital fractures. Identifying and repairing medial orbital wall defects by using appropriate materials improves patient outcome considerably; however, most related research has focused on orbital floor defect management rather than medial orbital wall treatment, and no consensus on repairing medial orbital wall fractures exists. Furthermore, medial orbital wall fracture is a main cause of posttraumatic enophthalmos...
February 14, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28194344/correlation-between-the-2-dimensional-extent-of-orbital-defects-and-the-3-dimensional-volume-of-herniated-orbital-content-in-patients-with-isolated-orbital-wall-fractures
#14
Jong Hyun Cha, Myeong Ho Moon, Yong Hae Lee, In Chang Koh, Kyu Nam Kim, Chang Gyun Kim, Hoon Kim
BACKGROUND: The purpose of this study was to assess the correlation between the 2-dimensional (2D) extent of orbital defects and the 3-dimensional (3D) volume of herniated orbital content in patients with an orbital wall fracture. METHODS: This retrospective study was based on the medical records and radiologic data of 60 patients from January 2014 to June 2016 for a unilateral isolated orbital wall fracture. They were classified into 2 groups depending on whether the fracture involved the inferior wall (group I, n=30) or the medial wall (group M, n=30)...
January 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28193444/surgical-navigation-a-systematic-review-of-indications-treatments-and-outcomes-in-oral-and-maxillofacial-surgery
#15
REVIEW
Iman Azarmehr, Kasper Stokbro, R Bryan Bell, Torben Thygesen
PURPOSE: This systematic review investigates the most common indications, treatments, and outcomes of surgical navigation (SN) published from 2010 to 2015. The evolution of SN and its application in oral and maxillofacial surgery have rapidly developed over recent years, and therapeutic indications are discussed. MATERIALS AND METHODS: A systematic search in relevant electronic databases, journals, and bibliographies of the included articles was carried out. Clinical studies with 5 or more patients published between 2010 and 2015 were included...
January 18, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28185781/classification-of-orbital-exenteration-and-reconstruction
#16
Marco R Kesting, Steffen Koerdt, Niklas Rommel, Thomas Mücke, Klaus-Dietrich Wolff, Christopher P Nobis, Florian Ringel, Gesche Frohwitter
Orbital exenteration (OE) is considered to be a mutilating surgical procedure reserved for relentlessly progressive neoplastic disorders or extensive facial trauma with unfavourable eye involvement. Malignant tumours, accounting for the majority of ablative orbital surgeries, may be caused by primary orbital tumours or secondarily by neoplasias from the surrounding skin, the maxillary sinus or intracranial malignomas. Orbital exenteration following trauma is mostly caused by penetrating globe defects or extended infections with the danger of intracranial effects...
January 10, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28179700/calvarial-remodelling-surgery-neurosurgical-experience-of-multidisciplinary-craniofacial-reconstruction
#17
Abdul Ghaffar, Zahid Hussain, Shahzad Ahmed Qasmi, Shahid Hameed Chaudhry
OBJECTIVE: To evaluate the safety, cosmetic and functional outcome of craniofacial reconstruction surgery for primary craniosynostosis and clefts. METHODS: This quasi-experimental study was conducted at the Combined Military Hospital, Rawalpindi, Pakistan, from June 2011 to December 2014, and comprised paediatric patients undergoing calvarial reconstructive procedures. Fronto-orbital advancement and reconstruction, total calvarial remodelling and box flap reconstruction techniques were used...
December 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28169905/reconstruction-of-large-orbital-posterior-floor-wall-fracture-considering-orbital-floor-slope-using-endoscope
#18
Jinhwan Park, Jungah Huh, Joonsik Lee, Minwook Chang, Hwa Lee, Minsoo Park, Sehyun Baek
PURPOSE: Reconstruction of a large orbital fracture extending to the posterior wall of the maxillary sinus is difficult and challenging. In this study, the authors present transconjunctival or transcaruncular approach using endoscopy and layered porous polyethylene barrier sheets to manage large orbital floor wall fracture. METHODS: A retrospective review of all patients who underwent reconstruction of large orbital floor wall fractures between June 2009 and July 2015 was conducted...
February 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28169904/endoscopic-transnasal-transpterygoid-excision-of-an-infratemporal-dermoid-cyst
#19
Gökhan Kuran, Demet Yazici
OBJECTIVE: Intracranial dermoid cysts are rare, slow-growing masses of sellar, parasellar regions, and posterior cranial fossa. The symptomatology of these cysts depends on the localization and presence of rupture. The preoperative diagnosis of these cysts by imagining techniques is distinctive as they have characteristic appearances. PATIENT: Endoscopic transnasal transpterygoid approach to infratemporal fossa for an extradural dermoid cyst of a 24 year-old woman is presented in this clinical report...
February 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28168075/metastatic-renal-cell-carcinoma-presenting-as-a-paranasal-sinus-mass-the-importance-of-differential-diagnosis
#20
Massimo Ralli, Giancarlo Altissimi, Rosaria Turchetta, Mario Rigante
Metastases in the paranasal sinuses are rare; renal cell carcinoma is the most common cancer that metastasizes to this region. We present the case of a patient with a 4-month history of a rapidly growing mass of the nasal pyramid following a nasal trauma, associated with spontaneous epistaxis and multiple episodes of hematuria. Cranial CT scan and MRI showed an ethmoid mass extending to the choanal region, the right orbit, and the right frontal sinus with an initial intracranial extension. Patient underwent surgery with a trans-sinusal frontal approach using a bicoronal incision combined with an anterior midfacial degloving; histological exam was compatible with a metastasis of clear cell renal cell carcinoma...
2017: Case Reports in Otolaryngology
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