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https://www.readbyqxmd.com/read/28734628/adrenergic-receptor-genotypes-influence-postoperative-outcomes-in-infants-in-the-single-ventricle-reconstruction-trial
#1
Ronand Ramroop, George Manase, Danny Lu, Dorin Manase, Shan Chen, Richard Kim, Teresa Lee, William T Mahle, Kimberly McHugh, Mike Mitchell, Martin Tristani-Firouzi, Stephanie B Wechsler, Nicole S Wilder, Victor Zak, Myriam Lafreniere-Roula, Jane W Newburger, J William Gaynor, Mark W Russell, Seema Mital
OBJECTIVES: Adrenergic receptor (ADR) genotypes have been associated with adverse outcomes in heart failure. Our objective was to evaluate the association of ADR genotypes with post-Norwood outcomes in infants with hypoplastic left heart syndrome (HLHS). METHODS: Infants with HLHS participating in the Pediatric Heart Network Single-Ventricle Reconstruction Trial underwent genotyping for 4 single-nucleotide polymorphisms in 3 ADR genes: ADRB1_231A/G, ADRB1_1165G/C, ADRB2_5318C/G, and ADRA2A_2790C/T...
June 24, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28727711/high-body-mass-index-is-a-potential-risk-factor-for-persistent-postoperative-pain-after-breast-cancer-treatment
#2
Noud van Helmond, Hans Timmerman, Nick T van Dasselaar, Carmen C van de Pol, Soren S Olesen, Asbjorn M Drewes, Kris Vissers, Oliver H Wilder-Smith, Monique A Steegers
BACKGROUND: Risk factors associated with persistent pain after breast cancer treatment are needed to develop prevention and treatment strategies to improve the quality of life for patients with breast cancer. OBJECTIVES: To identify factors associated with persistent pain in women undergoing breast cancer treatments. STUDY DESIGN: Retrospective study. SETTING: Regional hospital in the Netherlands. METHODS: The primary outcome was pain associated with surgery at more than 6 months postoperatively and patients were stratified based on the associated visual analog" scale score they reported: reporting no pain as "no pain," pain 1 - 29 mm as "mild pain," and pain 30 - 100 mm as "moderate/severe pain...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28724108/yellow-perch-perca-flavescens-mercury-unaffected-by-wildland-fires-in-northern-minnesota
#3
Charlotte E Riggs, Randall K Kolka, Edward A Nater, Emma L Witt, Trent R Wickman, Laurel G Woodruff, Jason T Butcher
Wildland fire can alter mercury (Hg) cycling on land and in adjacent aquatic environments. In addition to enhancing local atmospheric Hg redeposition, fire can influence terrestrial movement of Hg and other elements into lakes via runoff from burned upland soil. However, the impact of fire on water quality and the accumulation of Hg in fish remain equivocal. We investigated the effects of fire-specifically, a low-severity prescribed fire and moderate-severity wildfire-on young-of-the-year yellow perch () and lake chemistry in a small remote watershed in the Boundary Waters Canoe Area Wilderness in northeastern Minnesota...
May 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28722181/historical-biome-distribution-and-recent-human-disturbance-shape-the-diversity-of-arbuscular-mycorrhizal-fungi
#4
Meelis Pärtel, Maarja Öpik, Mari Moora, Leho Tedersoo, Robert Szava-Kovats, Søren Rosendahl, Matthias C Rillig, Ylva Lekberg, Holger Kreft, Thorunn Helgason, Ove Eriksson, John Davison, Francesco de Bello, Tancredi Caruso, Martin Zobel
The availability of global microbial diversity data, collected using standardized metabarcoding techniques, makes microorganisms promising models for investigating the role of regional and local factors in driving biodiversity. Here we modelled the global diversity of symbiotic arbuscular mycorrhizal (AM) fungi using currently available data on AM fungal molecular diversity (small subunit (SSU) ribosomal RNA (rRNA) gene sequences) in field samples. To differentiate between regional and local effects, we estimated species pools (sets of potentially suitable taxa) for each site, which are expected to reflect regional processes...
July 19, 2017: New Phytologist
https://www.readbyqxmd.com/read/28719296/analysis-of-dengue-serotype-4-in-sri-lanka-during-the-2012-2013-dengue-epidemic
#5
Anna Uehara, Hasitha Aravinda Tissera, Champica K Bodinayake, Ananda Amarasinghe, Ajith Nagahawatte, L Gayani Tillekeratne, Jie Cui, Megan E Reller, Paba Palihawadana, Sunethra Gunasena, Aruna Dharshan Desilva, Annelies Wilder-Smith, Duane J Gubler, Christopher W Woods, October M Sessions
The four serotypes of dengue virus (DENV-1, -2, -3, and -4) have had a rapidly expanding geographic range and are now endemic in over 100 tropical and subtropical countries. Sri Lanka has experienced periodic dengue outbreaks since the 1960s, but since 1989 epidemics have become progressively larger and associated with more severe disease. The dominant virus in the 2012 epidemic was DENV-1, but DENV-4 infections were also commonly observed. DENV-4 transmission was first documented in Sri Lanka when it was isolated from a traveler in 1978, but has been comparatively uncommon since dengue surveillance began in the early 1980s...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28716154/new-insights-from-gorongosa-national-park-and-niassa-national-reserve-of-mozambique-increasing-the-genetic-diversity-of-trypanosoma-vivax-and-trypanosoma-vivax-like-in-tsetse-flies-wild-ungulates-and-livestock-from-east-africa
#6
Carla Mf Rodrigues, Herakles A Garcia, Adriana C Rodrigues, André G Costa-Martins, Carlos L Pereira, Dagmar L Pereira, Zakaria Bengaly, Luis Neves, Erney P Camargo, Patrick B Hamilton, Marta Mg Teixeira
BACKGROUND: Trypanosoma (Duttonella) vivax is a major pathogen of livestock in Africa and South America (SA), and genetic studies limited to small sampling suggest greater diversity in East Africa (EA) compared to both West Africa (WA) and SA. METHODS: Multidimensional scaling and phylogenetic analyses of 112 sequences of the glycosomal glyceraldehyde phosphate dehydrogenase (gGAPDH) gene and 263 sequences of the internal transcribed spacer of rDNA (ITS rDNA) were performed to compare trypanosomes from tsetse flies from Gorongosa National Park and Niassa National Reserve of Mozambique (MZ), wild ungulates and livestock from EA, and livestock isolates from WA and SA...
July 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28713645/effects-of-a-novel-disc-formulation-on-dry-mouth-symptoms-and-enamel-remineralization-in-patients-with-hyposalivation-an-in-vivo-study
#7
Jessica Ho, Miracle Vania Firmalino, Afarin Golabgir Anbarani, Thair Takesh, Joel Epstein, Petra Wilder-Smith
BACKGROUND: The goal of this study was to identify the in vivo effects in patients with hyposalivation of a novel slowly dissolving adhering test disc upon on enamel remineralization, oral biofilm, salivary production, pH and buffering, gingival health, and on self-evaluation of oral well-being. METHODS: Five subjects with xerostomia wore custom made retainers carrying 5 demineralized enamel chips for periods of 1 week each. In 1 study arm, subjects used the test agent plus oral hygiene self-care; in the other they used oral hygiene self-care only, with a 1 week washout in between arms...
February 2017: Dentistry: Current Research
https://www.readbyqxmd.com/read/28707935/multipoint-measurements-of-the-electron-jet-of-symmetric-magnetic-reconnection-with-a-moderate-guide-field
#8
F D Wilder, R E Ergun, S Eriksson, T D Phan, J L Burch, N Ahmadi, K A Goodrich, D L Newman, K J Trattner, R B Torbert, B L Giles, R J Strangeway, W Magnes, P-A Lindqvist, Yu-V Khotyaintsev
We report observations from the Magnetospheric Multiscale (MMS) satellites of the electron jet in a symmetric magnetic reconnection event with moderate guide field. All four spacecraft sampled the ion diffusion region and observed the electron exhaust. The observations suggest that the presence of the guide field leads to an asymmetric Hall field, which results in an electron jet skewed towards the separatrix with a nonzero component along the magnetic field. The jet appears in conjunction with a spatially and temporally persistent parallel electric field ranging from -3 to -5  mV/m, which led to dissipation on the order of 8  nW/m^{3}...
June 30, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28706755/effects-of-a-novel-whitening-formulation-on-dental-enamel
#9
Thair Takesh, Anik Sargsyan, Afarin Anbarani, Jessica Ho, Petra Wilder-Smith
OBJECTIVE: The goal of this study was to evaluate the enamel whitening effects of 2 new test formulations, one of which was a rinse, and the other a whitening strip. MATERIALS AND METHODS: Forty enamel chips were prepared from 20 healthy extracted teeth (2 from each tooth). After pre-staining and colorimetry to measure L* and b* values, 20 matched samples were immersed in either test or control rinses, and then colorimetry was performed again after 1 hr, 2 hr, 3 hr, 6 hr, 12 hr, 24 hr and 48 hrs (Each hour equates to one month of clinical use at the recommended dosage of 1 minute exposure 2 times a day)...
April 2017: Dentistry: Current Research
https://www.readbyqxmd.com/read/28675351/on-the-origin-and-timing-of-zika-virus-introduction-in-brazil
#10
E Massad, M Nascimento Burattini, K Khan, C J Struchiner, F A B Coutinho, A Wilder-Smith
The timing and origin of Zika virus (ZIKV) introduction in Brazil has been the subject of controversy. Initially, it was assumed that the virus was introduced during the FIFA World Cup in June-July 2014. Then, it was speculated that ZIKV may have been introduced by athletes from French Polynesia (FP) who competed in a canoe race in Rio de Janeiro in August 2014. We attempted to apply mathematical models to determine the most likely time window of ZIKV introduction in Brazil. Given that the timing and origin of ZIKV introduction in Brazil may be a politically sensitive issue, its determination (or the provision of a plausible hypothesis) may help to prevent undeserved blame...
June 15, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28675233/integrated-sudomotor-axon-reflex-sweat-stimulation-for-continuous-sweat-analyte-analysis-with-individuals-at-rest
#11
Zachary Sonner, Eliza Wilder, Trudy Gaillard, Gerald Kasting, Jason Heikenfeld
Eccrine sweat has rapidly emerged as a non-invasive, ergonomic, and rich source of chemical analytes with numerous technological demonstrations now showing the ability for continuous electrochemical sensing. However, beyond active perspirers (athletes, workers, etc.), continuous sweat access in individuals at rest has hindered the advancement of both sweat sensing science and technology. Reported here is integration of sudomotor axon reflex sweat stimulation for continuous wearable sweat analyte analysis, including the ability for side-by-side integration of chemical stimulants & sensors without cross-contamination...
July 4, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28667836/adenosine-a2a-receptor-blockade-diminishes-wnt-%C3%AE-catenin-signaling-in-a-murine-model-of-bleomycin-induced-dermal-fibrosis
#12
Jin Zhang, Carmen Corciulo, Hailing Liu, Tuere Wilder, Mayumi Ito, Bruce Cronstein
Adenosine A2a receptor (A2aR) stimulation promotes the synthesis of collagens I and III, and we have recently demonstrated that there is crosstalk between the A2aR and WNT/β-catenin signaling pathway. In in vitro studies, A2aR signaling for collagen III expression was mediated by WNT/β-catenin signaling in human dermal fibroblasts; we further verified whether the crosstalk between A2aR and Wnt/β-catenin signaling was involved in diffuse dermal fibrosis in vivo. Wnt-signaling reporter mice (Tcf/Lef:H2B-GFP) were challenged with bleomycin and treated with the selective A2aR antagonist istradefylline (KW6002) or vehicle...
June 28, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28667708/acute-painful-autoimmune-neuropathy-a-variant-of-guillain-barr%C3%A3-syndrome
#13
Nobuhiro Yuki, Amanda C Chan, Anna Hiu Yi Wong, Takayuki Inoue, Masafumi Yokai, Takashi Kurihara, Jérôme J Devaux, Einar Wilder-Smith
Introduction We present a painful small fibre neuropathy variant of Guillain-Barré syndrome. Methods characterized by antecedent infectious symptoms, hyporeflexia and albuminocytologic dissociation. Results Two patients received intravenous immunoglobulin, and subsequently improved. IgG antibodies in their acute phase sera strongly bound to murine small nerve fibres, and the binding disappeared during the convalescent phase. Serum transfer to a murine nociceptive model induced transient alteration in thermal pain responses...
July 1, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28666664/young-infants-with-severe-tetralogy-of-fallot-early-primary-surgery-versus-transcatheter-palliation
#14
Travis J Wilder, Glen S Van Arsdell, Lee Benson, Eric Pham-Hung, Michael Gritti, Alexandra Page, Christopher A Caldarone, Edward J Hickey
BACKGROUND: Infants with severe tetralogy of Fallot may undergo (1) early primary surgical repair (EARLY) or (2) early transcatheter palliation (CATH) before delayed surgical repair. We compared these strategies with (3) elective single-stage tetralogy of Fallot repair (IDEAL). METHODS: From 2000 to 2012, 453 children underwent tetralogy of Fallot repair (excluding systemic-pulmonary shunts), including 383 in the IDEAL (75%), 42 in the EARLY (9%), and 28 in the CATH (6%) groups...
May 19, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28664996/gaps-and-opportunities-for-the-world-heritage-convention-to-contribute-to-global-wilderness-conservation
#15
James R Allan, Cyril Kormos, Tilman Jaeger, Oscar Venter, Bastian Bertzky, Yichuan Shi, Brendan Mackey, Remco van Merm, Elena Osipova, James E M Watson
Wilderness areas are ecologically intact landscapes predominantly free of human uses, especially industrial scale activities, which result in significant biophysical disturbance. This definition does not exclude indigenous peoples and local communities who live in wilderness areas, depending on them for subsistence, and who have developed deep bio-cultural connections. Wilderness areas are important for biodiversity conservation, along with sustaining key ecological processes, and ecosystem services that underpin planetary life-support systems...
June 30, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28661889/voices-in-the-wilderness-co-location-meeting-the-needs-of-children-in-protective-care
#16
Graham Swanson, Michael Mills, Amie Davis, Anne Kittler, Vivian R Ramsden
OBJECTIVE: To explore how access to a family medicine clinic co-locating with the Children's Aid Society (CAS) of Hamilton in Ontario helped meet the unique needs of children in care. DESIGN: Qualitative research using semistructured face-to-face and telephone interviews. SETTING: The CAS of Hamilton. PARTICIPANTS: Nineteen foster parents. METHODS: Stakeholders were invited to participate with flyers posted in the clinic, notices that were mailed to foster parents, personal invitations that were distributed during clinic visits, and an internal memo that was distributed to the CAS staff...
November 2016: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28657809/medical-oversight-educational-core-content-and-proposed-scopes-of-practice-of-wilderness-ems-providers-a-joint-project-developed-by-wilderness-ems-educators-medical-directors-and-regulators-using-a-delphi-approach
#17
Michael G Millin, David E Johnson, Tod Schimelpfenig, Keith Conover, Matthew Sholl, Jonnathan Busko, Rachael Alter, Will Smith, Jennifer Symonds, Peter Taillac, Seth C Hawkins
INTRODUCTION: A disparity exists between the skills needed to manage patients in wilderness EMS environments and the scopes of practice that are traditionally approved by state EMS regulators. In response, the National Association of EMS Physicians Wilderness EMS Committee led a project to define the educational core content supporting scopes of practice of wilderness EMS providers and the conditions when wilderness EMS providers should be required to have medical oversight. METHODS: Using a Delphi process, a group of experts in wilderness EMS, representing educators, medical directors, and regulators, developed model educational core content...
June 28, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28653798/spinal-cord-injury-pain-instrument-and-paindetect-questionnaire-convergent-construct-validity-in-individuals-with-spinal-cord-injury
#18
S Franz, C Schuld, E P Wilder-Smith, L Heutehaus, S Lang, S Gantz, S Schuh-Hofer, R-D Treede, T N Bryce, H Wang, N Weidner
BACKGROUND: Neuropathic pain (NeuP) is a frequent sequel of spinal cord injury (SCI). The SCI Pain Instrument (SCIPI) was developed as a SCI-specific NeuP screening tool. A preliminary validation reported encouraging results requiring further evaluation in terms of psychometric properties. The painDETECT questionnaire (PDQ), a commonly applied NeuP assessment tool, was primarily validated in German, but not specifically developed for SCI and not yet validated according to current diagnostic guidelines...
June 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28646888/utilization-of-hiv-testing-services-among-pregnant-mothers-in-low-income-primary-care-settings-in-northern-ethiopia-a-cross-sectional-study
#19
Yihun Mulugeta Alemu, Fentie Ambaw, Annelies Wilder-Smith
BACKGROUND: HIV testing of women in child bearing age is an entry point for preventing mother-to-child transmission of HIV (MTCT). This study aims to identify the proportion of women tested for HIV and to determine factors associated with utilization of HIV testing services among pregnant mothers in primary care settings in northern Ethiopia. METHODS: A cross sectional study was conducted in 416 pregnant women from four primary care centers between October 2, 2012 and May 31, 2013 in East Gojjam, Ethiopia...
June 24, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28645311/zika-virus-tropism-and-interactions-in-myelinating-neural-cell-cultures-cns-cells-and-myelin-are-preferentially-affected
#20
Stephanie L Cumberworth, Jennifer A Barrie, Madeleine E Cunningham, Daniely Paulino Gomes de Figueiredo, Verena Schultz, Adrian J Wilder-Smith, Benjamin Brennan, Lindomar J Pena, Rafael Freitas de Oliveira França, Christopher Linington, Susan C Barnett, Hugh J Willison, Alain Kohl, Julia M Edgar
The recent global outbreak of Zika virus (ZIKV) infection has been linked to severe neurological disorders affecting the peripheral and central nervous systems (PNS and CNS, respectively). The pathobiology underlying these diverse clinical phenotypes are the subject of intense research; however, even the principal neural cell types vulnerable to productive Zika infection remain poorly characterised. Here we used CNS and PNS myelinating cultures from wild type and Ifnar1 knockout mice to examine neuronal and glial tropism and short-term consequences of direct infection with a Brazilian variant of ZIKV...
June 23, 2017: Acta Neuropathologica Communications
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