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Samantha Schneider, Cecilia Blair Levandowski, Cory Manly, Robert Dellavalle, Cory A Dunnick
Exploring the mountains is a highly rewarding past time; however, certain high-altitude exposures can lead to dermatologic manifestations. In this review article, the authors will describe cold, solar, and severe weather that one may experience when spending time outdoors. Factors such as increased ultraviolet radiation, temperature extremes, and low partial pressure of oxygen, along with human physiologic parameters also contribute to disease severity and presentation. This review article will address the diagnosis, treatment, and prevention of high-altitude dermatology exposures...
November 15, 2017: Dermatology Online Journal
Noud van Helmond, Hans Timmerman, Søren S Olesen, Asbjørn M Drewes, Joris Kleinhans, Oliver H Wilder-Smith, Kris C Vissers, Monique A Steegers
Chronic pain following surgery, persistent postsurgical pain, is an important highly prevalent condition contributing to significant symptom burden and lower quality of life. Persistent postsurgical pain is relatively refractory to treatment hence generating a high need for preventive strategies and treatments. Therefore, the identification of patients at risk of developing persistent pain is an area of active ongoing research. Recently it was demonstrated that peri-operative disruptions in central pain processing may be able to predict persistent postsurgical pain at long term follow-up in breast cancer patients...
January 18, 2018: Journal of Visualized Experiments: JoVE
Michael Harding, Jessica Wilder, Meaghan Sledge Wido, Courtney Judd
No abstract text is available yet for this article.
February 7, 2018: Military Medicine
Trevor Robbins
No abstract text is available yet for this article.
February 8, 2018: Nature
Jose Fernandez-Triana
Ten new species within four genera of Microgastrinae parasitoid wasps (Hymenoptera: Braconidae) are described from Canada and United States: Diolcogaster ichiroi, Diolcogaster miamensis, Glyptapanteles pseudotsugae, Microgaster archboldensis, Microgaster syntopic, Microplitis altissimus, Microplitis jorgeluisi, Microplitis juanmanueli, Microplitis julioalbertoi, and Microplitis mariamargaritae. The new taxa are significant because they represent the first North American records of a tropical group (species of the basimacula group in Diolcogaster), exemplify interesting ecological cases (niche-based host selection in Glyptapanteles, syntopic species in Microgaster), and showcase unique morphological features and/or altitudinal records (Microplitis)...
2018: ZooKeys
Namita Shrestha, Govinda Chilkoor, Joseph Wilder, Zhiyong Jason Ren, Venkataramana Gadhamshetty
This study evaluates and compares the performance of microbial fuel cells (MFCs) and microbial capacitive deionization cells (MCDCs) fed with wastewater produced from the Bakken shale. The produced water was characterized by high levels of dissolved solids and chemical oxygen demand (COD). Two-compartment MFCs and three-compartment MCDCs were evaluated under batch-fed mode using mixed microbial consortia in the anode, ferricyanide in the cathode, and produced water as the electrolyte in the anode and capacitive deionization units...
January 11, 2018: Bioelectrochemistry
James Winter, Martin J Bishop, Catherine D E Wilder, Christopher O'Shea, Davor Pavlovic, Michael J Shattock
Rationale: Arrhythmogenic cardiac alternans are thought to be an important determinant for the initiation of ventricular fibrillation. There is limited information on the effects of sympathetic nerve stimulation (SNS) on alternans in the intact heart and the conclusions of existing studies, focused on investigating electrical alternans, are conflicted. Meanwhile, several lines of evidence implicate instabilities in Ca handling, not electrical restitution, as the primary mechanism underpinning alternans. Despite this, there have been no studies on Ca alternans and SNS in the intact heart...
2018: Frontiers in Physiology
Jeffrey Curran, Stephen D Ritchie, Jackson Beardy, David VanderBurgh, Karen Born, John Lewko, Aaron M Orkin
(1) Background: Remote communities in Canada lack an equitable emergency medical response capacity compared to other communities. Community-based emergency care (CBEC) training for laypeople is a model that has the potential to enhance the medical emergency response capacity in isolated and resource-limited contexts. The purpose of this study was to understand the characteristics of medical emergencies and to conceptualize and present a framework for what a medical emergency is for one remote Indigenous community in northwestern Ontario, in order to inform the development of CBEC training...
February 4, 2018: International Journal of Environmental Research and Public Health
Chang Soo Kim, Dominique Ingato, Petra Wilder-Smith, Zhongping Chen, Young Jik Kwon
A key design consideration in developing contrast agents is obtaining distinct, multiple signal changes in diseased tissue. Plasmonic gold nanoparticles (Au NPs) have been developed as contrast agents due to their strong surface plasmon resonance (SPR). This study aims to demonstrate that stimuli-responsive plasmonic Au nanoclusters (Au NCs) can be used as a contrast agent for optical coherence tomography (OCT) in detecting early-stage cancer. Au NPs were clustered via acid-cleavable linkers to synthesize Au NCs that disassemble under mildly acidic conditions into individual Au NPs, simultaneously diminishing SPR effect (quantified by scattering intensity) and increasing Brownian motion (quantified by Doppler variance)...
2018: Nano Convergence
Robert K Needleman, Isabelle P Neylan, Timothy Erickson
INTRODUCTION: Climate change has been scientifically documented, and its effects on wildlife have been prognosticated. We sought to predict the overall impact of climate change on venomous terrestrial species. We hypothesize that given the close relationship between terrestrial venomous species and climate, a changing global environment may result in increased species migration, geographical redistribution, and longer seasons for envenomation, which would have repercussions on human health...
January 29, 2018: Wilderness & Environmental Medicine
Aránzazu Mediero, Tuere Wilder, Lopa Shah, Bruce N Cronstein
The axonal guidance proteins semaphorin (Sema)4D and Sema3A play important roles in communication between osteoclasts and osteoblasts. As stimulation of adenosine A2A receptors (A2AR) regulates both osteoclast and osteoblast function, we asked whether A2AR regulates both osteoclast and osteoblast expression of Semas. In vivo bone formation and Sema3A/PlexinA1/Neuropilin-1, Sema4D/PlexinB1 protein expression were studied in a murine model of wear particle-induced osteolysis. Osteoclast/osteoblast differentiation were studied in vitro as the number of tartrate-resistant acid phosphatase+/Alizarin Red+ cells after challenge with CGS21680 (A2AR agonist, 1 µM) or ZM241385 (A2AR antagonist, 1 µM), with or without Sema4D or Sema3A (10 ng/ml)...
February 2, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Søren S Olesen, Theresa Krauss, Ihsan Ekin Demir, Oliver H Wilder-Smith, Güralp O Ceyhan, Pankaj J Pasricha, Asbjørn M Drewes
Introduction: Chronic pancreatitis (CP) is a disease characterized by inflammation of the pancreas resulting in replacement of the normal functioning parenchyma by fibrotic connective tissue. This process leads to progressively impairment of exocrine and endocrine function and many patients develop a chronic pain syndrome. Objectives: We aimed to characterize the neurobiological signature of pain associated with CP and to discuss its implications for treatment strategies...
November 2017: Pain Reports (Baltimore, Md.)
Mohamed Henriques, José Pedro Granadeiro, Hamilton Monteiro, Ana Nuno, Miguel Lecoq, Paulo Cardoso, Aissa Regalla, Paulo Catry
Vultures constitute an important functional group in many ecosystems, providing crucial ecosystem services both in natural and humanized environments. These scavengers are facing massive declines worldwide, but in several African countries virtually nothing is known on populations' status and threats, hampering the development of adequate conservation strategies. In Guinea-Bissau, globally important populations of Hooded Necrosyrtes monachus and African white-backed vultures Gyps africanus were recently reported...
2018: PloS One
Rebecca S Wilder
No abstract text is available yet for this article.
December 2017: Journal of Dental Hygiene: JDH
Walter A Schrading, Nicole Battaglioli, Jonathan Drew, Sarah Frances McClure
Wilderness medicine training has become increasingly popular among medical professionals with numerous educational opportunities nationwide. Curricula for fellowship programs and for medical student education have previously been developed and published, but a specific curriculum for wilderness medicine education during emergency medicine (EM) residency has not. The objective of this study is to create a longitudinal wilderness medicine curriculum that can be incorporated into an EM residency program. Interest-specific tracks are becoming increasingly common in EM training...
January 16, 2018: Wilderness & Environmental Medicine
Richard Leblanc
Harvey Cushing and Wilder Penfield enjoyed a unique professional and personal relationship. Shortly before his retirement from Harvard University in 1933, Cushing sent Penfield 8 sketches that he drew in 1902 and 1903 while he was at Johns Hopkins Hospital. The first series of 3 sketches illustrate the relationship between a cortical hemorrhagic lesion and the motor strip in a patient with focal motor seizures. The second series also comprises 3 sketches. These depict the operative findings in a patient in whom Cushing had electrically stimulated the precentral gyrus, before resecting the cortex subserving motility of the upper extremity to control painful dyskinetic movements...
January 26, 2018: Journal of Neurosurgery
Alexandra L Rhue, Beth VanDerveer
Wilderness first responders are trained to provide competent medical care in wilderness settings or until evacuation for more advanced treatment can be obtained. In light of the isolated environments in which they are called upon to respond to illnesses and injuries, their ability to effectively apply their training is crucial. Despite the responsibility assigned to them, there is an absence of research assessing the skill and knowledge retention of wilderness first responders, creating a gap in understanding whether a deficit in their ability to perform exists between certifications...
January 17, 2018: Wilderness & Environmental Medicine
Juliana de Andrade Santiago, Maria das Graças Cardoso, Luis Roberto Batista, Wilder Douglas Santiago, Fabiana Reinis Franca Passamani, Leonardo Milani Avelar Rodrigues, David Lee Nelson
The influence of essential oils (EOs) extracted from the leaves of Melaleuca alternifolia, Melaleuca quinquenervia and Backhousia citriodora on ochratoxin A (OTA) synthesis by fungi was studied. The extraction of EOs was performed by hydrodistillation (Clevenger apparatus) over a 2-h period and subsequently analyzed by GC-MS and GC-FID. The toxigenic activity of the essential oils (31.25; 15.62 and 7.81 µg mL-1) was evaluated by inhibiting the production of OTA by Aspergillus niger and Aspergillus carbonarius in Czapek agar medium culture...
January 2018: Journal of Food Science and Technology
Alicia Byrne
No abstract text is available yet for this article.
January 18, 2018: Wilderness & Environmental Medicine
Alicia E Bennett, Michael J Wilder, J Scott McNally, Jana J Wold, Gregory J Stoddard, Jennifer J Majersik, Safdar Ansari, Adam de Havenon
BACKGROUND AND PURPOSE: Blood pressure variability has been found to contribute to worse outcomes after intravenous tissue plasminogen activator, but the association has not been established after intra-arterial therapies. METHODS: We retrospectively reviewed patients with an ischemic stroke treated with intra-arterial therapies from 2005 to 2015. Blood pressure variability was measured as standard deviation (SD), coefficient of variation (CV), and successive variation (SV)...
January 19, 2018: Journal of Neurointerventional Surgery
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