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https://www.readbyqxmd.com/read/28637782/the-brugada-syndrome-susceptibility-gene-hey2-modulates-cardiac-transmural-ion-channel-patterning-and-electrical-heterogeneity
#1
Christiaan C Veerman, Svitlana Podliesna, Rafik Tadros, Elisabeth M Lodder, Isabella Mengarelli, Berend de Jonge, Leander Beekman, Julien Barc, Ronald Wilders, Arthur A Wilde, Bastiaan J Boukens, Ruben Coronel, Arie Verkerk, Carol Ann Remme, Connie R Bezzina
Rationale: Genome-wide association studies previously identified an association of rs9388451 at chromosome 6q22.3 (near HEY2) with Brugada syndrome (BrS). The causal gene and underlying mechanism remain unresolved. Objective: We used an integrative approach entailing transcriptomic studies in human hearts and electrophysiological studies in Hey2 heterozygous knockout mice (Hey2(+/-) ) to dissect the underpinnings of the 6q22.31 association with BrS. Methods and Results: We queried expression quantitative trait locus (eQTL) data acquired in 190 human left ventricular (LV) samples from the Genotype-Tissue Expression (GTEx) consortium for cis-eQTL effects of rs9388451 which revealed an association between BrS risk allele dosage and HEY2 expression (β=+0...
June 21, 2017: Circulation Research
https://www.readbyqxmd.com/read/28633549/an-update-on-zika-vaccine-developments
#2
Anna Durbin, Annelies Wilder-Smith
The devastating consequences of congenital Zika virus (ZIKV) infection led to a global response directed toward a better understanding of the epidemiology and pathogenesis of ZIKV and to efforts at vaccine development. As a result, there are currently 45 ZIKV vaccine candidates in development. Areas covered: Both traditional (purified inactivated, live attenuated, viral-vectored, recombinant sub-unit) and novel (DNA, self-replicating RNA, mRNA) vaccine platforms are being utilized. For emergency use, vaccines that are appropriate for women of child-bearing age (including pregnant women) are being developed...
June 21, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28633543/staffs-documentation-of-participation-for-adults-with-profound-intellectual-disability-or-profound-intellectual-and-multiple-disabilities
#3
Lena Talman, Christine Gustafsson, Jonas Stier, Jenny Wilder
PURPOSE: This study investigated what areas of International Classification of Functioning, Disability and Health were documented in implementation plans for adults with profound intellectual disability or profound intellectual and multiple disabilities with focus on participation. METHODS: A document analysis of 17 implementation plans was performed and International Classification of Functioning, Disability and Health was used as an analytic tool. RESULTS: One hundred and sixty-three different codes were identified, especially in the components Activities and participation and Environmental factors...
June 21, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28614727/micronutrient-consumption-by-female-argiope-bruennichi-affects-offspring-survival
#4
Shawn M Wilder, Jutta M Schneider
Sexual cannibalism has long been hypothesized to be a foraging decision in which females consume males for the nutrients in their bodies. While few studies have documented fecundity benefits of sexual cannibalism, several recent studies have documented benefits of cannibalism to egg hatching success or offspring survival. We tested if small supplements of dietary essential nutrients fed to female spiders, Argiope bruennichi, would result in increases in offspring survival similar to those seen following sexual cannibalism...
June 11, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28611949/pseudomalabsorption-of-levothyroxine-a-challenge-for-the-endocrinologist-in-the-treatment-of-hypothyroidism
#5
Nancy Van Wilder, Bert Bravenboer, Sarah Herremans, Nathalie Vanderbruggen, Brigitte Velkeniers
BACKGROUND: Hypothyroidism due to non-compliance with levothyroxine therapy (pseudomalabsorption) is rare. The diagnosis is considered in patients with persistent severe hypothyroidism despite treatment with large doses of levothyroxine. Intestinal malabsorption, drug and dietary interference with levothyroxine absorption and nephrotic syndrome should be excluded. The diagnosis of pseudomalabsorption can be demonstrated by using "an oral 1,000 µg of levothyroxine test" showing a rapid decrease in thyroid-stimulating hormone and increase in thyroxine...
February 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28609464/a-multi-scale-evaluation-of-pack-stock-effects-on-subalpine-meadow-plant-communities-in-the-sierra-nevada
#6
Steven R Lee, Eric L Berlow, Steven M Ostoja, Matthew L Brooks, Alexandre Génin, John R Matchett, Stephen C Hart
We evaluated the influence of pack stock (i.e., horse and mule) use on meadow plant communities in Sequoia and Yosemite National Parks in the Sierra Nevada of California. Meadows were sampled to account for inherent variability across multiple scales by: 1) controlling for among-meadow variability by using remotely sensed hydro-climatic and geospatial data to pair stock use meadows with similar non-stock (reference) sites, 2) accounting for within-meadow variation in the local hydrology using in-situ soil moisture readings, and 3) incorporating variation in stock use intensity by sampling across the entire available gradient of pack stock use...
2017: PloS One
https://www.readbyqxmd.com/read/28609302/association-between-exposure-of-young-children-to-procedures-requiring-general-anesthesia-and-learning-and-behavioral-outcomes-in-a-population-based-birth-cohort
#7
Danqing Hu, Randall P Flick, Michael J Zaccariello, Robert C Colligan, Slavica K Katusic, Darrell R Schroeder, Andrew C Hanson, Shonie L Buenvenida, Stephen J Gleich, Robert T Wilder, Juraj Sprung, David O Warner
BACKGROUND: Exposure of young animals to general anesthesia causes neurodegeneration and lasting behavioral abnormalities; whether these findings translate to children remains unclear. This study used a population-based birth cohort to test the hypothesis that multiple, but not single, exposures to procedures requiring general anesthesia before age 3 yr are associated with adverse neurodevelopmental outcomes. METHODS: A retrospective study cohort was assembled from children born in Olmsted County, Minnesota, from 1996 to 2000 (inclusive)...
June 13, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28608851/a-global-dataset-of-crowdsourced-land-cover-and-land-use-reference-data
#8
Steffen Fritz, Linda See, Christoph Perger, Ian McCallum, Christian Schill, Dmitry Schepaschenko, Martina Duerauer, Mathias Karner, Christopher Dresel, Juan-Carlos Laso-Bayas, Myroslava Lesiv, Inian Moorthy, Carl F Salk, Olha Danylo, Tobias Sturn, Franziska Albrecht, Liangzhi You, Florian Kraxner, Michael Obersteiner
Global land cover is an essential climate variable and a key biophysical driver for earth system models. While remote sensing technology, particularly satellites, have played a key role in providing land cover datasets, large discrepancies have been noted among the available products. Global land use is typically more difficult to map and in many cases cannot be remotely sensed. In-situ or ground-based data and high resolution imagery are thus an important requirement for producing accurate land cover and land use datasets and this is precisely what is lacking...
June 13, 2017: Scientific Data
https://www.readbyqxmd.com/read/28602272/prevention-of-friction-blisters-in-outdoor-pursuits-a-systematic-review
#9
REVIEW
Robert M Worthing, Raechel L Percy, Jeremy D Joslin
The purpose of this systematic review was to determine if sock, antiperspirant, or barrier strategies were effective in prevention of friction blisters in wilderness and outdoor pursuits. A search of PubMed and EMBASE was conducted. Title, abstract, and full text articles were screened by 2 authors using predetermined inclusion and exclusion criteria to identify prospective controlled trials investigating prevention methods for friction blisters involving the foot. Only blisters associated with wilderness and outdoor pursuits (running, hiking, marching, etc...
June 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28602271/animal-microbial-and-fungal-borne-skin-pathology-in-the-mountain-wilderness-a-review
#10
REVIEW
William E Brandenburg, William Levandowski, Tom Califf, Cory Manly, Cecilia Blair Levandowski
Mountains are home to numerous organisms known to cause skin disease. Bites, stings, poisons, chemicals, toxins, trauma, and infections all contribute to this end. Numerous plants, animals, fungi, bacteria, viruses, and protozoa are responsible. This paper aims to review skin illness and injury sustained from organisms in the mountains of North America. Other factors such as increased ultraviolet radiation, temperature extremes, and decreasing atmospheric pressure along with human physiologic parameters, which contribute to disease severity, will also be discussed...
June 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28601211/the-symbiotic-relationship-between-operational-military-medicine-tactical-medicine-and-wilderness-medicine-a-view-through-a-personal-lens
#11
REVIEW
Craig H Llewellyn
There are direct and indirect linkages and a form of symbiosis between operational military medicine from World War II and present wilderness medicine, from the beginnings to contemporary practice, and the more recently evolved field of tactical emergency medical support. Each of these relationships will be explored from the historical perspective of the Department of Military & Emergency Medicine, Uniformed Services University of the Health Sciences from 1982 to the present.
June 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28601208/bleeding-control-with-limb-tourniquet-use-in-the-wilderness-setting-review-of-science
#12
REVIEW
John F Kragh, Michael A Dubick
The purpose of this review is to summarize tourniquet science for possible translation to wilderness settings. Much combat casualty data has been studied since 2005, and use of tourniquets in the military has changed from a last resort to first aid. The US Government has made use of tourniquets a health policy aimed to improve public access to bleeding control items. International authorities believe that education in first aid should be universal, as all can and should learn first aid. The safety record of tourniquet use is mixed, but users are reliably safe if trained well...
June 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28601206/prolonged-field-care-beyond-the-golden-hour
#13
REVIEW
Sean Keenan, Jamie C Riesberg
Prolonged field care (PFC) has emerged as a recent area of focus for US military Special Operations Forces (SOF) medical experts. Focused on the current reality of providing medical care to military forces often deployed in remote and austere locations far from medical support or a robust casualty evacuation chain, PFC encompasses evolving operational situations not unlike many wilderness medicine practice environments. SOF currently operates in all areas of the world and on a variety of different missions, which finds these small teams far from the accustomed practice environment of robust deployed medical infrastructure commonly seen during the last 15 years of military conflicts...
June 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28599647/association-of-lumbar-spine-stiffness-and-flexion-relaxation-phenomenon-with-patient-reported-outcomes-in-adults-with-chronic-low-back-pain-a-single-arm-clinical-trial-investigating-the-effects-of-thrust-spinal-manipulation
#14
Ting Xia, Cynthia R Long, Robert D Vining, Maruti R Gudavalli, James W DeVocht, Gregory N Kawchuk, David G Wilder, Christine M Goertz
BACKGROUND: Spinal manipulation (SM) is used commonly for treating low back pain (LBP). Spinal stiffness is routinely assessed by clinicians performing SM. Flexion-relaxation ratio (FRR) was shown to distinguish between LBP and healthy populations. The primary objective of this study was to examine the association of these two physiological variables with patient-reported pain intensity and disability in adults with chronic LBP (>12 weeks) receiving SM. METHODS: A single-arm trial provided 12 sessions of side-lying thrust SM in the lumbosacral region over 6 weeks...
June 9, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28599051/maggot-therapy-for-wound-care-in-austere-environments
#15
Ronald A Sherman, Michael R Hetzler
The past 25 years have seen an increase in use of maggot therapy for wound care. Maggot therapy is very effective in wound debridement; it is simple to apply and requires very little in the way of resources, costs, or skilled personnel. These characteristics make it well suited for use in austere environments. The use of medical-grade maggots makes maggot therapy nearly risk free, but medical grade maggots may not always be available, especially in the wilderness or in resource-limited communities. By understanding myiasis and fly biology, it should be possible even for the nonentomologist to obtain maggots from the wild and apply them therapeutically, with minimal risks...
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28597051/effects-of-backpacker-use-pack-stock-trail-use-and-pack-stock-grazing-on-water-quality-indicators-including-nutrients-e-coli-hormones-and-pharmaceuticals-in-yosemite-national-park-usa
#16
Harrison Forrester, David Clow, James Roche, Alan Heyvaert, William Battaglin
We investigated how visitor-use affects water quality in wilderness in Yosemite National Park. During the summers of 2012-2014, we collected and analyzed surface-water samples for water-quality indicators, including fecal indicator bacteria Escherichia coli, nutrients (nitrogen, phosphorus, carbon), suspended sediment concentration, pharmaceuticals, and hormones. Samples were collected upstream and downstream from different types of visitor use at weekly to biweekly intervals and during summer storms. We conducted a park-wide synoptic sampling campaign during summer 2014, and sampled upstream and downstream from meadows to evaluate the mitigating effect of meadows on water quality...
June 8, 2017: Environmental Management
https://www.readbyqxmd.com/read/28549924/applications-of-single-molecule-methods-to-membrane-protein-folding-studies
#17
REVIEW
Robert E Jefferson, Duyoung Min, Karolina Corin, Jing Yang Wang, James U Bowie
Protein folding is a fundamental life process with many implications throughout biology and medicine. Consequently, there have been enormous efforts to understand how proteins fold. Almost all of this effort has focused on water-soluble proteins, however, leaving membrane proteins largely wandering in the wilderness. The neglect has not occurred because membrane proteins are unimportant, but rather because they present many theoretical and technical complications. Indeed, quantitative membrane protein folding studies are generally restricted to a handful of well-behaved proteins...
May 23, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28521696/nanotechnology-as-a-promising-strategy-for-anticancer-drug-delivery
#18
Mona Basha
Cancer was and still a very stressful and urgent disease condition representing a leading cause of death in developed as well as developing countries. Although, much research work in both medical and pharmaceutical fields has evolved in the past few years in addition to some promising clinical trials and few market products, cancer becomes much wilder, threatening and getting more lives. Most approaches have focused on the synthesis of new active ingredients or chemical modification of available ones, formulating them in suitable dosage forms aiming for targeted and effective drug delivery with minimal side effects...
May 15, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28502667/mechanosensitivity-from-aristotle-s-sense-of-touch-to-cardiac-mechano-electric-coupling
#19
REVIEW
Johann P Kuhtz-Buschbeck, Jochen Schaefer, Nicolaus Wilder
Scientific interest in mechanosensation likely commenced with Aristotle's description of the sense of touch in his treatise de Anima [On the Soul]. Considering touch as a vital sense distributed over the whole body, the philosopher outlined a "physiological concept" at the macro-level already 2400 years ago. From this starting point, we outline the onset of modern sensory physiology during the early 19th century. Physiologists distinguished between outer and inner senses at that time, without, however, referring to specific receptors or nerves...
May 11, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28501413/managing-traumatic-brain-injury-translating-military-guidelines-to-the-wilderness
#20
REVIEW
Edward J Otten, Warren C Dorlac
Traumatic brain injury (TBI) is a common injury on the battlefield. Much of what medics do to manage these injuries on the battlefield can be translated to other austere environments, such as wilderness or disaster settings. The recognition and diagnosis of TBI can be difficult even in the hospital, but basic understanding of how to define a TBI and prevent secondary injuries can be accomplished with relatively few resources and little training. This article outlines what a TBI is and how to manage it in the field...
June 2017: Wilderness & Environmental Medicine
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