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James S Molton, Isaac Low, Milly Ming Ju Choy, Pauline Poh Kim Aw, Martin L Hibberd, Paul A Tambyah, Annelies Wilder-Smith
Zika and Ebola viruses can persist in semen and pose a risk for sexual transmission. To determine if dengue virus, another flavivirus, is similarly detectable in semen, we performed dengue PCR on semen in five patients with acute dengue virus infection. All five tested negative, suggesting that dengue does not pose a risk for sexual transmission.
January 1, 2018: Journal of Travel Medicine
David O Warner, Michael J Zaccariello, Slavica K Katusic, Darrell R Schroeder, Andrew C Hanson, Phillip J Schulte, Shonie L Buenvenida, Stephen J Gleich, Robert T Wilder, Juraj Sprung, Danqing Hu, Robert G Voigt, Merle G Paule, John J Chelonis, Randall P Flick
BACKGROUND: Few studies of how exposure of children to anesthesia may affect neurodevelopment employ comprehensive neuropsychological assessments. This study tested the hypothesis that exposure to multiple, but not single, procedures requiring anesthesia before age 3 yr is associated with adverse neurodevelopmental outcomes. METHODS: Unexposed, singly exposed, and multiply exposed children born in Olmsted County, Minnesota, from 1994 to 2007 were sampled using a propensity-guided approach and underwent neuropsychological testing at ages 8 to 12 or 15 to 20 yr...
April 19, 2018: Anesthesiology
A Wilder-Smith, E Massad
BACKGROUND: A yellow fever epidemic occurred in Angola in 2016 with 884 laboratory confirmed cases and 373 deaths. Eleven unvaccinated Chinese nationals working in Angola were also infected and imported the disease to China, thereby presenting the first importation of yellow fever into Asia. In Angola, there are about 259,000 Chinese foreign workers. The fact that 11 unvaccinated Chinese workers acquired yellow fever suggests that many more Chinese workers in Angola were not vaccinated...
April 17, 2018: BMC Infectious Diseases
Michelle M Johannsen, Kenneth J Shin, Karolina Priebe, Robert H Coker
INTRODUCTION: The Alaska Mountain Wilderness Ski Classic is a self-supported ultramarathon cross-country skiing event that traverses one of the mountain ranges of Alaska each winter. Unique aspects of this event challenge athletes with a significant amount of physical and mental stress while in the chronically cold conditions of the Arctic. Assessment of energy requirements or body composition has never been performed during this event. The objective of the study was to evaluate the influence of the 2016 Alaska Mountain Wilderness Ski Classic on caloric expenditure and body composition...
April 5, 2018: Wilderness & Environmental Medicine
(no author information available yet)
No abstract text is available yet for this article.
April 4, 2018: Wilderness & Environmental Medicine
Sonja Emily Leonhard, Suzannah Lant, Bart C Jacobs, Annelies Wilder-Smith, Maria Lucia Brito Ferreira, Tom Solomon, Hugh John Willison
Zika virus has been associated with a wide range of neurological complications. Neurologists in areas without current active transmission of the virus may be confronted with Zika-associated neurological disease, as a large number of returning travellers with Zika virus infection have been reported and the virus continues to spread to previously unaffected regions. This review provides an overview of Zika virus-associated neurological disease and aims to support neurologists who may encounter patients returning from endemic areas...
April 4, 2018: Practical Neurology
Feng Li, Masao Kakoki, Marcela Smid, Kim Boggess, Jennifer Wilder, Sylvia Hiller, Carol Bounajim, Scott E Parnell, Kathleen K Sulik, Oliver Smithies, Nobuyo Maeda-Smithies
Endothelin-1 (ET-1) is implicated in the pathophysiology of preeclampsia. An association between an EDN1 gene polymorphism with high ET-1 and preeclampsia was reported in humans, but their cause and effect relationships have not been defined. We examined the pregnancy effects in mice with a modified Edn1 allele that increases mRNA stability and thus ET-1 production. Heterozygous Edn1 H/+ females showed no obvious abnormalities before pregnancy, but when mated with wild-type (WT) males developed a full spectrum of preeclampsia-like phenotypes, including increased systolic blood pressure, proteinuria, glomerular endotheliosis, and intrauterine fetal growth restriction...
April 2, 2018: Hypertension
J van Vliet, A A Tieleman, A Verrips, H Timmerman, R T M van Dongen, B G M van Engelen, O H G Wilder-Smith
Pain is a common but often ignored symptom in patients with myotonic dystrophy type 2 (DM2). In this explorative study, we assessed qualitative and quantitative aspects of pain in DM2 by means of four questionnaires and quantitative sensory testing. Both a disease control group (fibromyalgia (FMS)) and healthy controls were used to compare the results, as pain in DM2 shows many clinical similarities to pain in FMS. Thirty-four patients with genetically confirmed DM2 (71% female, mean age 54 years), 28 patients with FMS and 33 healthy controls were included, both age- and sex-matched...
March 27, 2018: Journal of Pain: Official Journal of the American Pain Society
Jeffrey S Kreutzer, Jennifer H Marwitz, Daniel W Klyce, Kathryn P Wilder Schaaf, Adam P Sima, Abigail M Welch, Janet P Niemeier
OBJECTIVE: To examine the needs of family members in an inpatient setting and factors predicting extent to which needs are perceived as met. SETTING: University health system inpatient rehabilitation unit. PARTICIPANTS: Adult survivors of traumatic brain injury and family members (n = 85). DESIGN: Prospective, cross-sectional. MAIN MEASURE: Family Needs Questionnaire-Revised (FNQ-R). RESULTS: Needs related to the Health Information subscale were most frequently rated as met, whereas needs related to the Instrumental Support and Emotional Support subscales were most frequently rated as unmet...
March 29, 2018: Journal of Head Trauma Rehabilitation
Kathryn B Ireland, Andrew J Hansen, Robert E Keane, Kristin Legg, Robert L Gump
Natural resource managers face the need to develop strategies to adapt to projected future climates. Few existing climate adaptation frameworks prescribe where to place management actions to be most effective under anticipated future climate conditions. We developed an approach to spatially allocate climate adaptation actions and applied the method to whitebark pine (WBP; Pinus albicaulis) in the Greater Yellowstone Ecosystem (GYE). WBP is expected to be vulnerable to climate-mediated shifts in suitable habitat, pests, pathogens, and fire...
March 29, 2018: Environmental Management
Vincent Portero, Ronald Wilders, Simona Casini, Flavien Charpentier, Arie O Verkerk, Carol Ann Remme
In cardiomyocytes, the voltage-gated transient outward potassium current (Ito ) is responsible for the phase-1 repolarization of the action potential (AP). Gain-of-function mutations in KCND3 , the gene encoding the Ito carrying KV 4.3 channel, have been associated with Brugada syndrome (BrS). While the role of Ito in the pro-arrhythmic mechanism of BrS has been debated, recent studies have suggested that an increased Ito may directly affect cardiac conduction. However, the effects of an increased Ito on AP upstroke velocity or sodium current at the cellular level remain unknown...
2018: Frontiers in Physiology
Christopher T Lewis, W L Malein, Ian Chesner, S Clarke
INTRODUCTION: Measurement of physiological parameters in extreme environments is essential to advancing knowledge, prophylaxis and treatment of altitude sickness. Point-of-care testing facilitates investigation in non-specialist and remote settings, as well as becoming increasingly popular at the bedside for real-time results in the clinical environment. Arterialised capillary earlobe blood gases are recommended as a valid alternative to arterial sampling in research. This study aimed to test the feasibility of obtaining and analysing daily earlobe samples at high altitude...
March 25, 2018: Journal of the Royal Army Medical Corps
Annelies Wilder-Smith
No abstract text is available yet for this article.
March 23, 2018: Clinical Microbiology and Infection
Tiantian Jiang, Keats Shwab, Robbie Martin, Richard Gerhold, Benjamin Rosenthal, Jitender P Dubey, Chunlei Su
Toxoplasma gondii counts among the most consequential food-borne parasites, and although the parasite occurs in a wide range of wild and domesticated animals, farms may constitute a specific and important locus of transmission. If so, parasites in animals that inhabit agricultural habitats might be suspected of harboring genetically distinct parasite types. To better understand habitat effects pertinent to this parasite's transmission, we compiled and analyzed existing genotypic data of 623 samples from animals across a proximity gradient from areas of human settlement to the wilderness in North America...
March 22, 2018: International Journal for Parasitology
Steven G Schauer, Jason F Naylor, Derek J Brown, Robert V Gibbons, Ian Syndergaard, Tracy Cushing
INTRODUCTION: In 2014, the Wilderness Medical Society (WMS) published guidelines for the treatment of acute pain in remote settings. We surveyed wilderness medicine providers on self-reported analgesia prescribing practices. METHODS: We conducted a prospective, anonymous survey. Respondents were recruited from the WMS annual symposium in 2016. All willing attendees were included. RESULTS: During the symposium, we collected a total of 124 surveys (68% response rate)...
March 22, 2018: Wilderness & Environmental Medicine
N Esteban, R K F Unsworth, J B Q Gourlay, G C Hays
Our understanding of global seagrass ecosystems comes largely from regions characterized by human impacts with limited data from habitats defined as notionally pristine. Seagrass assessments also largely focus on shallow-water coastal habitats with comparatively few studies on offshore deep-water seagrasses. We satellite tracked green turtles (Chelonia mydas), which are known to forage on seagrasses, to a remote, pristine deep-water environment in the Western Indian Ocean, the Great Chagos Bank, which lies in the heart of one of the world's largest marine protected areas (MPAs)...
March 21, 2018: Marine Pollution Bulletin
Raimund Lechner, Thomas Küpper, Markus Tannheimer
INTRODUCTION: History is full of examples of the influence of the mountain environment on warfare. The aim of this article is to identify the main environmental hazards and summarize countermeasures to mitigate the impact of this unique environment. METHODS: A selective PubMed and Internet search was conducted. Additionally, we searched bibliographies for useful supplemental literature and included the recommendations of the leading mountain medicine and wilderness medicine societies...
March 16, 2018: Wilderness & Environmental Medicine
Eduardo Massad, Marcos Amaku, Francisco Antonio Bezerra Coutinho, Claudio José Struchiner, Marcelo Nascimento Burattini, Kamran Khan, Jing Liu-Helmersson, Joacim Rocklöv, Moritz U G Kraemer, Annelies Wilder-Smith
Given the speed of air travel, diseases even with a short viremia such as dengue can be easily exported to dengue naïve areas within 24 hours. We set out to estimate the risk of dengue virus introductions via travelers into Europe and number of secondary autochthonous cases as a result of the introduction. We applied mathematical modeling to estimate the number of dengue-viremic air passengers from 16 dengue-endemic countries to 27 European countries, taking into account the incidence of dengue in the exporting countries, travel volume and the probability of being viremic at the time of travel...
March 15, 2018: Scientific Reports
Travis J Wilder
No abstract text is available yet for this article.
March 2018: World Journal for Pediatric & Congenital Heart Surgery
Travis J Wilder
No abstract text is available yet for this article.
February 8, 2018: Journal of Thoracic and Cardiovascular Surgery
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