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Haptoglobin

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https://www.readbyqxmd.com/read/28525506/haptoglobin-administration-in-cardiovascular-surgery-patients-its-association-with-the-risk-of-postoperative-acute-kidney-injury
#1
Kenta Kubota, Moritoki Egi, Satoshi Mizobuchi
BACKGROUND: Acute kidney injury (AKI) often occurs after cardiac surgery. During cardiac surgery, plasma free hemoglobin (fHb) would increase due to hemolysis. Since plasma fHb is thought to be nephrotoxic, haptoglobin, which is an fHb scavenger, may have the potential to prevent postoperative AKI (pAKI). However, there have been few studies in which the association of intraoperative administration of haptoglobin with the incidence of AKI after cardiac surgery was assessed. METHODS: This study was a retrospective observational study to assess the independent association of intraoperative administration of haptoglobin with the incidence pAKI in cardiac surgery patients...
June 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28524240/potential-serum-biomarkers-associated-with-mild-and-severe-leptospirosis-infection-a-cohort-study-in-the-malaysian-population
#2
Tan Xue Ting, Fairuz Binti Amran, Ravindran Thayan, Norazah Ahmad, Roslinda Jaafar, Rahimah Haron, Rafidah Abdullah, Sazwan Reezal Bin Shamsuddin, Nor Suhaila Binti Md Riffin, Puteri Shafinaz Abdul-Rahman
Leptospirosis is an emerging zoonotic infectious disease in Malaysia. The symptoms of leptospirosis vary from mild non-specific flu-like illness to a severe condition which is usually associated with serious complication and fatality. To study the protein expression profile of mild and severe leptospirosis, fifteen paired sera were collected from the patients who were mildly infected and following that progressed to severe stage. The proteome profiles of mild and severe cases were studied using 2DE analysis in combination with LC-MS/MS...
May 19, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28514971/effects-of-organic-complexed-or-inorganic-co-cu-mn-and-zn-supplementation-during-a-45-day-preconditioning-period-on-productive-and-health-responses-of-feeder-cattle
#3
K D Lippolis, R F Cooke, L G T Silva, K M Schubach, A P Brandao, R S Marques, C K Larson, J R Russell, S A Arispe, T DelCurto, D W Bohnert
This experiment evaluated production and health parameters among cattle offered concentrates containing inorganic or organic complexed sources of supplemental Cu, Co, Mn and Zn during a 45-day preconditioning period. In total, 90 Angus×Hereford calves were weaned at 7 months (day -1), sorted by sex, weaning BW and age (261±2 kg; 224±2 days), and allocated to 18 drylot pens (one heifer and four steers per pen) on day 0; thus, all pens had equivalent initial BW and age. Pens were randomly assigned to receive a corn-based preconditioning concentrate containing: (1) Cu, Co, Mn and Zn sulfate sources (INR), (2) Cu, Mn, Co and Zn complexed organic source (AAC) or (3) no Cu, Co, Mn and Zn supplementation (CON)...
May 18, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28514126/-haptoglobin-polymorphism-as-an-independent-predictor-of-diabetic-nephropathy-and-retinopathy
#4
Inbal Dahan, Nadia Thauho, Farid Nakhoul, Nakhoul Nakhoul, Hanin Jabaly, Evgeny Farber
The antioxidant protein haptoglobin (Hp) plays a major role in the development of diabetic complications such as diabetic nephropathy and retinopathy. In humans, two alleles of Hp were identified: 1 and 2 with three possible genotypes: 1-1, 2-1, and 2-2. The Hp protein products differ in their biochemical and biophysical properties, such as their antioxidant capacity. The Hp1 protein is superior to the Hp2 protein in binding to free hemoglobin and neutralizing its oxidative potential and the accompanying renal and retinal injury...
July 2016: Harefuah
https://www.readbyqxmd.com/read/28508977/thrombotic-microangiopathy-caused-by-interferon-%C3%AE-1b-for-multiple-sclerosis-a-case-report
#5
Haruomi Nishio, Tatsuo Tsukamoto, Takeshi Matsubara, Yoichiro Okada, Ryosuke Takahashi, Motoko Yanagita
A 41-year-old man with a history of multiple sclerosis (MS) developed thrombotic microangiopathy after taking interferon β-1b for 10 years. Although the relapse of his MS was well controlled under normal blood pressure, he had persistent nausea, anorexia, gait disturbance and visual disorder 1 month before admission. He showed lethargy and high blood pressure (180/102 mmHg). Laboratory test results revealed anemia and thrombocytopenia, elevated LDH and renal dysfunction. Urinary dipstick showed a 2+ result for proteinuria and 3+ for hematuria...
November 2016: CEN Case Reports
https://www.readbyqxmd.com/read/28507920/passenger-lymphocyte-syndrome-pls-a-single-center-retrospective-analysis-of-minor-abo-incompatible-liver-transplants
#6
Sévérine de Bruijn, Ester Philipse, Marie Madeleine Couttenye, Bart Bracke, Dirk Ysebaert, Peter Michielsen, Sven Francque, Thomas Vanwolleghem, Anke Verlinden
Background and Aims: Due to the shortage of donor livers, minor ABO-incompatible liver transplantations are commonly performed. Together with the allograft, immunocompetent B-lymphocytes, called passenger lymphocytes, are transplanted. In case of minor ABO-incompatibility, these passenger lymphocytes produce antibodies directed towards the recipient's red blood cells, which causes immune-mediated hemolysis, also known as the passenger lymphocyte syndrome (PLS). Although this is a self-limiting disorder, serious complications can occur, including graft failure...
March 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28506765/augmenter-of-liver-regeneration-alr-exhibits-a-dual-signaling-impact-on-hepatic-acute-phase-response
#7
Rania Dayoub, Leonhard Buerger, Sara Ibrahim, Michael Melter, Thomas S Weiss
The acute-phase response (APR) is an inflammatory process triggered mainly by IL-6 in response to neoplasm, tissue injury, infection or inflammation. Signaling of IL-6 is transduced by activating STAT3 which rapidly results in production of acute-phase proteins (APPs) such as fibrinogen β (FGB) and haptoglobin (HP). Augmenter of liver regeneration (ALR), a hepatotrophic factor supporting liver regeneration, was reported to be upregulated after liver damage. In this study we analyzed the role of ALR for IL-6 signaling and APR...
May 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28504094/antimicrobial-activity-of-red-tailed-phascogale-phascogale-calura-serum
#8
Oselyne T W Ong, Jai M Green-Barber, Anusha Kanuri, Lauren J Young, Julie M Old
Antimicrobial substances in serum include circulating complement proteins and acute phase proteins (APPs). We identified gene sequences for APPs, haptoglobin (Hp), C-reactive protein (CRP) and serum amyloid A (SAA) in marsupial genomes. Hp and SAA levels were measured in red-tailed phascogale (Phascogale calura) sera using commercially available assays. Hp levels were higher in males than females, while SAA levels suggest the phascogales used in this study were healthy. Serum was co-cultured with four bacterial species...
April 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28503821/effects-of-continuous-low-dose-infusion-of-lipopolysaccharide-on-inflammatory-responses-milk-production-and-milk-quality-in-dairy-cows
#9
L T Ning, G Z Dong, C Ao, D G Zhang, K Erdene, F Q Zhang, J Wen, T L Zhang
The objective of this study was to evaluate the effects of continuous low dose infusion of lipopolysaccharide (LPS) on inflammatory responses and milk production and quality in lactating dairy cows. Eight Holstein cows were assigned to two treatments in a cross-over experimental design. Cows were infused intravenously either with saline solution or with saline solution containing LPS from Escherichia coli O111:B4 at a dose of 0.01 μg LPS/kg body weight for approximately 6 hr each day during a seven-day trial...
May 15, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28502961/haptoglobin-reduces-inflammatory-cytokine-inf-%C3%AE-and-facilitates-clot-formation-in-acute-severe-burn-rat-model
#10
Hiroyuki Koami, Yuichiro Sakamoto, Taku Miyasho, Ryo Noguchi, Norio Sato, Keita Kai, Kosuke Chris Yamada, Satoshi Inoue
Haptoglobin exerts renal protective function by scavenging free hemoglobin from the urine and blood stream in patients with hemolytic disorders. Recent studies elucidate the relationships between haptoglobin and inflammation. In addition, coagulopathy is often induced by systemic inflammation characterized by the presence of vascular endothelial damage. We hypothesize that haptoglobin might have an anti-inflammatory effect and affect hypercoagulability using rat burn model. Thirty anesthetized rats of six-weeks of age received over 30% full-thickness scald burn on the dorsal skin surface...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28487337/haptoglobin-hp2-variant-promotes-premature-cardiovascular-death-in-stroke-survivors
#11
Ijäs Petra, Susanna Melkas, Jani Saksi, Antti Jula, Matti Jauhiainen, Niku Oksala, Tarja Pohjasvaara, Markku Kaste, Pekka J Karhunen, Perttu Lindsberg, Timo Erkinjuntti
BACKGROUND AND PURPOSE: Haptoglobin (Hp) is an acute phase plasma protein protecting tissues from oxidative damage. It exists in 2 variant alleles (hp1/hp2) giving rise to 3 protein isoforms with different biochemical properties and efficiency to limit oxidative stress. We previously found that hp2 variant is associated with stroke risk in the patients with carotid stenosis and the risk of ischemic cardiovascular events in a general population cohort. This study examined the hypothesis that Hp genotype is associated with general cardiovascular risk in patients with stroke...
May 9, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28473932/acquired-thrombotic-thrombocytopenic-purpura-in-a-patient-with-pernicious-anemia
#12
Ramesh Kumar Pandey, Sumit Dahal, Kamal Fadlalla El Jack Fadlalla, Shambhu Bhagat, Bikash Bhattarai
Introduction. Acquired thrombotic thrombocytopenic purpura (TTP) has been associated with different autoimmune disorders. However, its association with pernicious anemia is rarely reported. Case Report. A 46-year-old male presented with blood in sputum and urine for one day. The vitals were stable. The physical examination was significant for icterus. Lab tests' results revealed leukocytosis, macrocytic anemia, severe thrombocytopenia, renal dysfunction, and unconjugated hyperbilirubinemia. He had an elevated LDH, low haptoglobin levels with many schistocytes, nucleated RBCs, and reticulocytes on peripheral smear...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28470739/vitamin-d-treatment-modulates-immune-activation-in-cystic-fibrosis
#13
Terezia Pincikova, Dominic Paquin-Proulx, Johan K Sandberg, Malin Flodström-Tullberg, Lena Hjelte
Persistent inflammatory response in cystic fibrosis (CF) airways is believed to play a central role in the progression of lung damage. Anti-inflammatory treatment may slow down lung disease progression but adverse side effects have limited its use. Vitamin D has immunoregulatory properties. We randomized 16 CF patients to receive vitamin D2, vitamin D3 or to serve as controls, and investigated the effect of vitamin D supplementation on soluble immunological parameters, myeloid dendritic cells (mDCs) and T cell activation...
May 3, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28469086/iron-accelerates-hemoglobin-oxidation-increasing-mortality-in-vascular-diseased-guinea-pigs-following-transfusion-of-stored-blood
#14
Jin Hyen Baek, Ayla Yalamanoglu, Yamei Gao, Ricardo Guenster, Donat R Spahn, Dominik J Schaer, Paul W Buehler
Non-transferrin-bound iron (NTBI) and free hemoglobin (Hb) accumulate in circulation following stored RBC transfusions. This study investigated transfusion, vascular disease, and mortality in guinea pigs after stored RBC transfusion alone and following cotransfusion with apo-transferrin (apo-Tf) and haptoglobin (Hp). The effects of RBC exchange transfusion dose (1, 3, and 9 units), storage period (14 days), and mortality were evaluated in guinea pigs with a vascular disease phenotype. Seven-day mortality and the interaction between iron and Hb as cocontributors to adverse outcome were studied...
May 4, 2017: JCI Insight
https://www.readbyqxmd.com/read/28468695/a-multiparametric-approach-to-discriminate-the-impacts-of-different-degrees-of-invasiveness-of-surgical-procedures-in-sheep
#15
M Faure, V Paulmier, A Boissy, A de La Foye, A de Boyer Des Roches, D Durand
Traumatic situations in animals induce responses including pain, expressed through behavioural and physiological pathways such as inflammation, oxidative stress, hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system. As some of these systems can also be activated during excitement and situations with a positive valence, their use as a means to assess pain response is difficult. We explored (i) how these five aforementioned pathways change in sheep exposed to various degrees of invasiveness of surgical procedures despite a therapeutic regimen and (ii) whether a multiparametric analysis that combines information from these five pathways enhances the discrimination between these situations, and estimates the relative importance of these pathways in the response...
May 4, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28464519/the-haptoglobin-beta-subunit-sequesters-hmgb1-toxicity-in-sterile-and-infectious-inflammation
#16
Huan Yang, Haichao Wang, Yongjun Wang, Meghan Addorisio, Jianhua Li, Michael J Postiglione, Sangeeta S Chavan, Yousef Al-Abed, Daniel J Antoine, Ulf Andersson, Kevin J Tracey
BACKGROUND: Extra-corpuscular hemoglobin is an endogenous factor enhancing inflammatory tissue damage, a process counteracted by the hemoglobin-binding plasma protein haptoglobin composed of alpha and beta subunits connected by disulfide bridges. Recent studies established that haptoglobin also binds and sequesters another pro-inflammatory mediator, HMGB1, via triggering CD163 receptor-mediated anti-inflammatory responses involving heme oxygenase-1 expression and IL-10 release. The molecular mechanism underlying haptoglobin-HMGB1 interaction remains poorly elucidated...
May 2, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28464098/effects-of-hydroxychloride-sources-of-copper-zinc-and-manganese-on-measures-of-supplement-intake-mineral-status-and-pre-and-postweaning-performance-of-beef-calves
#17
L S Caramalac, A Saran Netto, P G M A Martins, P Moriel, J Ranches, H J Fernandes, J D Arthington
Our objective was to evaluate the effect of Cu, Zn, and Mn source on measures of 1) preferential intake of mineral-concentrated supplements and 2) mineral status and pre- and postweaning performance of beef calves. In Exp. 1, 4 trials were conducted to assess the effect of source of Cu (750 mg/kg; Trial 1), Zn (2,000 mg/kg; Trial 2), Mn (3,000 mg/kg; Trial 3), and all 3 elements (Trial 4) on preferential intake of mineral-concentrated supplements. Supplements differed only by source of Cu, Zn, and Mn, which included hydroxychloride (hydroxy), sulfate, and organic options...
April 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28459871/immunological-effects-of-reduced-mucosal-integrity-in-the-early-life-of-balb-c-mice
#18
Katja Maria Bendtsen, Camilla Hartmann Friis Hansen, Łukasz Krych, Kerstin Skovgaard, Witold Kot, Finn Kvist Vogensen, Axel Kornerup Hansen
Certain stimuli at the gut barrier may be necessary in early life to establish a proper balance of immune tolerance. We evaluated a compromised barrier in juvenile mice in relation to microbiota and local and systemic immunity. BALB/c mice were treated with a low dose of dextran sulfate sodium (DSS) with or without ampicillin and lipopolysaccharide (LPS) to clarify the importance of microbial antigens and interaction between microbial-associated patterns and toll-like receptors. The barrier breach resulted in increased plasma LPS, which was highest in mice treated simultaneously with ampicillin...
2017: PloS One
https://www.readbyqxmd.com/read/28457853/two-dimensional-electrophoresis-highlights-haptoglobin-beta-chain-as-an-additional-biomarker-of-congenital-disorders-of-glycosylation
#19
Arnaud Bruneel, Florence Habarou, Tanya Stojkovic, Grégory Plouviez, Laure Bougas, Fanny Guillemet, Nadine Brient, Dominique Henry, Thierry Dupré, Sandrine Vuillaumier-Barrot, Nathalie Seta
Congenital disorders of glycosylation (CDGs) are rare inherited disorders affecting glycosylation of proteins and lipids and sharing very heterogeneous multivisceral symptoms. The biochemical screening of these diseases is currently limited to electrophoresis or HPLC separation/quantification of serum transferrin glycoforms and is relatively frequently hampered by genetic polymorphism. Further, it has been shown that transferrin glycosylation can be very poorly affected in confirmed CDGs. We developed a fast and simple two-dimensional (2-DE) Western-blot analysis applied to the simultaneous detection of various serum glycoproteins, i...
April 27, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28455724/reevaluation-of-pholiota-squarrosa-lectin-reactive-haptoglobin-as-a-pancreatic-cancer-biomarker-using-an-improved-elisa-system
#20
Ken Kusama, Yuki Okamoto, Keiko Saito, Tsukasa Kasahara, Teizo Murata, Yasushi Ueno, Yuka Kobayashi, Yoshihiro Kamada, Eiji Miyoshi
An increase in Lewis- and core-type fucosylation of haptoglobin has been reported in patients with pancreatic cancer (PC), suggesting that fucosylated haptoglobin is a candidate PC biomarker. Previously, we developed a Pholiota squarrosa lectin antibody enzyme-linked immunosorbent assay (PhoSL-ELISA) system for the detection of core-fucosylated haptoglobin. However, with this methodology, positive results were only obtained for some patients with PC, demonstrating the need for a more sensitive detection system...
April 28, 2017: Glycoconjugate Journal
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