keyword
https://read.qxmd.com/read/38531171/efficacy-and-safety-of-mesenchymal-stem-cell-derived-microvesicles-in-mouse-inflammatory-arthritis
#21
JOURNAL ARTICLE
Shixiong Wei, Chenyang Lu, Sujia Li, Qiuping Zhang, Ruijuan Cheng, ShuYue Pan, QiuHong Wu, Xueting Zhao, Xinping Tian, Xiaofeng Zeng, Yi Liu
OBJECTIVE: To determine the effective and safe intravenous doses of mesenchymal stem cells (MSCs)-derived microvesicles (MVs) and to elucidate the possible causes of death in mice receiving high-dose MVs. METHODS: MVs were isolated from human MSCs by gradient centrifugation. Mice with collagen-induced arthritis were treated with different doses of intravenous MVs or MSCs. Arthritis severity, white blood cell count, and serum C-reactive protein levels were measured...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38530625/acute-high-output-heart-failure-with-pulmonary-hypertension-and-severe-liver-injury-caused-by-amlodipine-poisoning-a-case-report
#22
JOURNAL ARTICLE
Chenlong Wang, Qingcheng Zhu, Dingyu Tan, Joseph Walline, Yachao Wang
Acute high-output heart failure (HOHF) with pulmonary hypertension and liver injury caused by amlodipine poisoning is very rare. We report a 52-year-old woman who suffered from severe shock after an overdose of amlodipine. Hemodynamic monitoring showed that while her left ventricular systolic function and cardiac output were elevated, her systemic vascular resistance decreased significantly. At the same time, the size of her right heart, her central venous pressure, and the oxygen saturation of her central venous circulation all increased abnormally...
March 26, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38529787/practical-10-color-t-cell-panel-for-phenotyping-diverse-populations-using-spectral-flow-cytometry-a-beginner-s-guide
#23
JOURNAL ARTICLE
Sina Zargaran, Morvarid Oveisi, Chunxiang Sun, Abdelahhad Barbour, Michael Glogauer
Flow cytometry stands as the most employed high-throughput single-cell analysis technique, facilitating the profiling of remarkably diverse samples, such as blood, bone marrow and body fluids. In addition, it allows for the discrimination of diverse immune cell subsets, including infrequently encountered types like T regulatory cells and exhausted CD28Null T cells. However, analyzing rare immune cell subsets with conventional flow cytometry poses challenges stemming from factors like fluorophore overlap, compensation issues, and limited flexibility in fluorophore selection...
March 2024: Current protocols
https://read.qxmd.com/read/38529434/recovery-and-survival-of-patients-after-out-of-hospital-cardiac-arrest-a-literature-review-showcasing-the-big-picture-of-intensive-care-unit-related-factors
#24
REVIEW
Srdjan S Nikolovski, Aleksandra D Lazic, Zoran Z Fiser, Ivana A Obradovic, Jelena Z Tijanic, Violetta Raffay
As an important public health issue, out-of-hospital cardiac arrest (OHCA) requires several stages of high quality medical care, both on-field and after hospital admission. Post-cardiac arrest shock can lead to severe neurological injury, resulting in poor recovery outcome and increased risk of death. These characteristics make this condition one of the most important issues to deal with in post-OHCA patients hospitalized in intensive care units (ICUs). Also, the majority of initial post-resuscitation survivors have underlying coronary diseases making revascularization procedure another crucial step in early management of these patients...
February 2024: Curēus
https://read.qxmd.com/read/38529394/ultrasound-guided-fine-needle-aspiration-thyroglobulin-in-the-diagnosis-of-lymph-node-metastasis-of-differentiated-papillary-thyroid-carcinoma-and-its-influencing-factors
#25
JOURNAL ARTICLE
Xuejiao Su, Lei Shang, Can Yue, Buyun Ma
BACKGROUND: Ultrasound-guided fine needle aspiration thyroglobulin (FNA-Tg) is recommended for the diagnosis of lymph node metastasis (LNM) in differentiated thyroid cancer (DTC), but its optimal cutoff value remains controversial, and the effect of potential influencing factors on FNA-Tg levels is unclear. METHOD: In this study, a retrospective analysis was conducted on 281 patients diagnosed with DTC, encompassing 333 lymph nodes. We analyze the optimal cutoff value and diagnostic efficacy of FNA-Tg, while also evaluating the potential influence of various factors on FNA-Tg...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38528871/comparison-of-computed-tomography-perfusion-and-magnetic-resonance-dynamic-susceptibility-contrast-perfusion-weighted-imaging-in-canine-brain
#26
JOURNAL ARTICLE
Sangmin Lee, Soomin Park, Sungwha Hong, Soyeon Kim, Junghee Yoon, Jihye Choi
Brain perfusion allows for the evaluation of cerebral hemodynamics, particularly in brain infarcts and tumors. Computed tomography (CT) perfusion (CTP) provides reliable data; however, it has a limited scan field of view and radiation exposure. Magnetic resonance (MR) perfusion provides detailed imaging of small structures and a wide scan field of view. However, no study has compared CTP and MR perfusion and assessed the correlation between the perfusion parameters measured using CTP and MR perfusion. The aim of the present study was to assess the correlation and agreement of the cerebral perfusion derived from dynamic susceptibility contrast (DSC)-MRI and CTP in dogs...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38528555/formononetin-reverses-treg-th17-imbalance-in-immune-mediated-bone-marrow-failure-mice-by-regulating-the-pi3k-akt-signaling-pathway
#27
JOURNAL ARTICLE
Huixuan Lan, Wei Qiu, Jie Wu, Zhijing Hu, Xiaomin Zhang, Lingling Zhu
BACKGROUND: Severe aplastic anemia (SAA) is a syndrome of bone marrow failure which is life-threatening. Recent studies have demonstrated that CD4 + T cell subsets, including T regulatory (Treg) and T helper 17 (Th17) cells, play a pivotal role in the pathogenesis of SAA. Formononetin (FMN) is a natural compound extracted from the traditional Chinese medicine Huangqi, which has the ability to regulate the imbalance of Treg/Th17 cells in some inflammatory diseases. Nevertheless, the therapeutic effect of FMN in SAA has yet to be definitively established...
March 25, 2024: Chinese Medicine
https://read.qxmd.com/read/38528467/characteristics-of-high-frame-frequency-contrast-enhanced-ultrasound-in-renal-tumors
#28
JOURNAL ARTICLE
WeiPing Zhang, JingLing Wang, Li Chen
OBJECTIVE: This study aims to analyze the characteristics of high frame rate contrast-enhanced ultrasound (H-CEUS) in renal lesions and to improve the ability for differential diagnosis of renal tumors. METHODS: A total of 140 patients with renal lesions underwent contrast-enhanced ultrasound (CEUS) examination in the First Affiliated Hospital of Nanchang University from July 2022 to July 2023. Based on the tumor pathology and the results of enhanced CT, tumor patients were divided into malignant and benign groups...
March 25, 2024: BMC Medical Imaging
https://read.qxmd.com/read/38527908/status-of-b-lymphocyte-subsets-and-their-homing-markers-in-patients-with-post-kala-azar-dermal-leishmaniasis
#29
JOURNAL ARTICLE
Shilpa Sengupta, Deep Goswami, Bidhan Chakraborty, Surya Jyati Chaudhuri, Manab K Ghosh, Mitali Chatterjee
In visceral leishmaniasis, the Type II helper T cell predominance results in B cell modulation and enhancement of anti-leishmanial IgG. However, information regarding its dermal sequel, post-kala-azar dermal leishmaniasis (PKDL), remains limited. Accordingly, this study aimed to elucidate the B cell-mediated antibody-dependent/independent immune profiles of PKDL patients. In the peripheral blood of PKDL patients, immunophenotyping of B cell subsets was performed by flow cytometry and by immunohistochemistry at lesional sites...
March 2024: Parasite Immunology
https://read.qxmd.com/read/38527706/design-and-implementation-of-multicenter-pediatric-and-congenital-studies-with-cardiovascular-magnetic-resonance-big-data-in-smaller-bodies
#30
REVIEW
Michael P DiLorenzo, Simon Lee, Rahul H Rathod, Francesca Raimondi, Kanwal M Farooqi, Supriya S Jain, Margaret M Samyn, Tiffanie R Johnson, Laura J Olivieri, Mark A Fogel, Wyman W Lai, Pierangelo Renella, Andrew J Powell, Sujatha Buddhe, Caitlin Stafford, Jason N Johnson, Willem A Helbing, Kuberan Pushparajah, Inga Voges, Vivek Muthurangu, Kimberley G Miles, Gerald Greil, Colin J McMahon, Timothy C Slesnick, Brian M Fonseca, Shaine A Morris, Jonathan H Soslow, Lars Grosse-Wortmann, Rebecca S Beroukhim, Heynric B Grotenhuis
Cardiovascular magnetic resonance (CMR) has become the reference standard for quantitative and qualitative assessment of ventricular function, blood flow, and myocardial tissue characterization. There is a preponderance of large CMR studies and registries in adults; However, similarly powered studies are lacking for the pediatric and congenital heart disease (PCHD) population. To date, most CMR studies in children are limited to small single or multicenter studies, thereby limiting the conclusions that can be drawn...
March 23, 2024: Journal of Cardiovascular Magnetic Resonance
https://read.qxmd.com/read/38526586/flat-panel-detector-perfusion-imaging-and-conventional-multidetector-perfusion-imaging-in-patients-with-acute-ischemic-stroke-a-comparative-study
#31
JOURNAL ARTICLE
Bettina L Serrallach, Adnan Mujanovic, Nikolaos Ntoulias, Michael Manhart, Mattia Branca, Alex Brehm, Marios-Nikos Psychogios, Christoph C Kurmann, Eike I Piechowiak, Sara Pilgram-Pastor, Thomas Meinel, David Seiffge, Pasquale Mordasini, Jan Gralla, Tomas Dobrocky, Johannes Kaesmacher
PURPOSE: Flat-panel detector computed tomography (FDCT) is increasingly used in (neuro)interventional angiography suites. This study aimed to compare FDCT perfusion (FDCTP) with conventional multidetector computed tomography perfusion (MDCTP) in patients with acute ischemic stroke. METHODS: In this study, 19 patients with large vessel occlusion in the anterior circulation who had undergone mechanical thrombectomy, baseline MDCTP and pre-interventional FDCTP were included...
March 25, 2024: Clinical Neuroradiology
https://read.qxmd.com/read/38526489/physiologic-effects-of-ecmo-in-patients-with-severe-acute-respiratory-distress-syndrome
#32
JOURNAL ARTICLE
Elena Spinelli, Marco Giani, Douglas Slobod, Bertrand Pavlovsky, Michela di Pierro, Stefania Crotti, Alfredo Lissoni, Giuseppe Foti, Giacomo Grasselli, Tommaso Mauri
RATIONALE: Blood flow rate affects mixed venous oxygenation (SvO2 ) during venovenous extracorporeal membrane oxygenation (ECMO), with possible effects on the pulmonary circulation and the right heart function. OBJECTIVES: We aimed at describing the physiologic effects of different levels of SvO2 obtained by changing ECMO blood flow, in patients with severe ARDS receiving ECMO and controlled mechanical ventilation. METHODS: Low (SvO2 target 70-75%), intermediate (SvO2 target 75-80%) and high (SvO2 target > 80%) ECMO blood flows were applied for 30 minutes in random order in 20 patients...
March 25, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38525948/high-resolution-free-breathing-automated-quantitative-myocardial-perfusion-by-cardiovascular-magnetic-resonance-for-the-detection-of-functionally-significant-coronary-artery-disease
#33
JOURNAL ARTICLE
R Crawley, K P Kunze, X Milidonis, J Highton, S McElroy, S M Frey, D Hoefler, C Karamanli, N C K Wong, S J Backhaus, E Alskaf, R Neji, C M Scannell, S Plein, A Chiribiri
AIMS: Current assessment of myocardial ischaemia from stress perfusion cardiovascular magnetic resonance (SP-CMR) largely relies on visual interpretation. This study investigated the use of high-resolution free-breathing SP-CMR with automated quantitative mapping in the diagnosis of coronary artery disease (CAD). Diagnostic performance was evaluated against invasive coronary angiography (ICA) with fractional flow reserve (FFR) measurement. METHODS & RESULTS: Seven-hundred and three patients were recruited for SP-CMR using the research sequence at 3 Tesla...
March 25, 2024: European Heart Journal Cardiovascular Imaging
https://read.qxmd.com/read/38525887/comapping-cellular-content-and-extracellular-matrix-with-hemodynamics-in-intact-arterial-tissues-using-scanning-immunofluorescent-multiphoton-microscopy
#34
JOURNAL ARTICLE
Yasutaka Tobe, Anne M Robertson, Mehdi Ramezanpour, Juan R Cebral, Simon C Watkins, Fady T Charbel, Sepideh Amin-Hanjani, Alexander K Yu, Boyle C Cheng, Henry H Woo
Deviation of blood flow from an optimal range is known to be associated with the initiation and progression of vascular pathologies. Important open questions remain about how the abnormal flow drives specific wall changes in pathologies such as cerebral aneurysms where the flow is highly heterogeneous and complex. This knowledge gap precludes the clinical use of readily available flow data to predict outcomes and improve treatment of these diseases. As both flow and the pathological wall changes are spatially heterogeneous, a crucial requirement for progress in this area is a methodology for acquiring and comapping local vascular wall biology data with local hemodynamic data...
March 25, 2024: Microscopy and Microanalysis
https://read.qxmd.com/read/38525397/the-effect-of-dextrose-hypotonic-vs-saline-hydration-on-methotrexate-induced-nephrotoxicity-in-male-and-female-rats
#35
JOURNAL ARTICLE
Zahra Hasanpour, Samira Choopani, Farzaneh Ashrafi, Ardeshir Talebi, Mehdi Nematbaksh
BACKGROUND: High-dose methotrexate (HDMTX) as a cytotoxic agent might cause various side effects. Hyperhydration has been implemented as the major strategy to decrease the potential risk of toxicities induced by HDMTX. This study aims to assess the renoprotective effect of hydration with dextrose water (DW) 5% versus normal saline (N/S) 0.9% against methotrexate (MTX) induced nephrotoxicity. MATERIALS AND METHODS: This experimental animal study has been conducted on 36 Wistar rats (200-250 g) categorized into six groups, including male ( n = 6) and female ( n = 6) rats receiving sodium chloride 0...
2024: Advanced Biomedical Research
https://read.qxmd.com/read/38523733/resistance-training-in-cardiovascular-diseases-a-review-on-its-effectiveness-in-controlling-risk-factors
#36
REVIEW
Arnengsih Nazir, Henhen Heryaman, Cep Juli, Azizah Ugusman, Januar Wibawa Martha, Marina Annette Moeliono, Nur Atik
Cardiovascular Disease (CVD), a term encompassing various disorders affecting the heart and blood vessels, includes coronary artery disease (CAD). CAD is primarily due to the development of atherosclerotic plaques that disrupt blood flow, oxygenation, and nutrient delivery to the myocardium. Risk factors contributing to CAD progression include smoking, hypertension, diabetes mellitus (DM), dyslipidaemia, and obesity. While aerobic exercise (AE) has shown promising results in controlling CVD risk factors, the impact of resistance training (RT) has not been extensively investigated...
2024: Integrated Blood Pressure Control
https://read.qxmd.com/read/38523455/analysis-of-changes-in-high-mobility-group-box-1-receptor-for-advanced-glycation-endproducts-and-t-helper-17-regulatory-t-balance-in-severe-preeclampsia-with-acute-heart-failure
#37
JOURNAL ARTICLE
Chen De, Liang Xuan, Zhang Jingjing, Zhang Honghong, Zuo Kun, Du Song, Song Yaqi, Jiang Ying, Cheng Cheng, Liu Jian
We measured the levels of High-Mobility Group Box 1 (HMGB1), Receptor for Advanced Glycation Endproducts (RAGE), T Helper 17 cells (Th17), Regulatory T cells (Treg), and related cytokines in the peripheral blood of patients with severe preeclampsia (SPE) complicated with acute heart failure (AHF) to explore the expression changes in these indicators. In total, 96 patients with SPE admitted to Gansu Provincial Maternity and Child-care Hospital between June 2020 and June 2022 were included in the study. The patients were divided into SPE+AHF (40 patients) and SPE (56 patients) groups based on whether they suffered from AHF...
March 24, 2024: Journal of Clinical Hypertension
https://read.qxmd.com/read/38522769/are-all-measures-of-liver-kp-uu-a-function-of-f-h-as-determined-following-oral-dosing-or-have-we-made-a-critical-error-in-defining-hepatic-drug-clearance
#38
JOURNAL ARTICLE
L Z Benet, J K Sodhi
Here we present, utilizing universally accepted relationships for hepatic clearance at steady state, that for all models of hepatic elimination the ratio of unbound liver drug concentration to unbound systemic blood concentration, Kpuu , is a function of or related to the hepatic bioavailability for that drug, FH . According to the derivation for the well-stirred model, Kpuu can never exceed unity, can frequently be a function of hepatic blood flow, and is equivalent to the value of FH as determined following oral dosing...
March 22, 2024: European Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38522507/biomarkers-of-endothelial-glycocalyx-damage-are-associated-with-microvascular-dysfunction-in-resuscitated-septic-shock-patients
#39
JOURNAL ARTICLE
Nazir Soubine Neto, Marcela Curci Vieira de Almeida, Helton de Oliveira Couto, Carlos Henrique Miranda
BACKGROUND: Microvascular dysfunction plays a central role in organ dysfunction during septic shock. Endothelial glycocalyx (eGC) damage could contribute to impaired microcirculation. The aim was to assess whether several eGC-damaged biomarkers are associated with microvascular dysfunction in resuscitated septic shock patients. METHODS: This cross-sectional study included resuscitated septic shock patients (N = 31), and a group of healthy individuals (N = 20)...
March 22, 2024: Microvascular Research
https://read.qxmd.com/read/38520703/photocurable-extracellular-matrix-sealant-for-cessation-of-venous-hemorrhage
#40
JOURNAL ARTICLE
Luke E Schepers, Brooke L Martindale, Alycia G Berman, Hannah L Cebull, William Van Alstine, Sydney E Hollingshead, Tyler Novak, Craig J Goergen
Hemorrhage is the second leading cause of death in patients under 46 years of age in the United States. Cessation of hemorrhage prevents hemorrhagic shock and tissue hypoxia. Controlling the bleed via direct pressure or tourniquet is often the first line of defense, but long-term care requires staples, hemostatic agents, or sealants that seal the vessel and restore blood flow. Here, we compare a new photocurable extracellular matrix sealant (pcECM) with low, medium, and high crosslink density formulations to a commercially available fibrin-based sealant, TISSEEL®...
April 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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