keyword
Keywords enterococcus faecalis virulenc...

enterococcus faecalis virulence factors

https://read.qxmd.com/read/37811975/the-population-level-impact-of-enterococcus-faecalis-genetics-on-intestinal-colonization-and-extraintestinal-infection
#21
JOURNAL ARTICLE
Chrispin Chaguza, Anna K Pöntinen, Janetta Top, Sergio Arredondo-Alonso, Ana R Freitas, Carla Novais, Carmen Torres, Stephen D Bentley, Luisa Peixe, Teresa M Coque, Rob J L Willems, Jukka Corander
Enterococcus faecalis is a commensal bacterium of the human gastrointestinal tract that causes opportunistic infections. The E. faecalis genetic changes associated with pathogenicity, particularly gut-to-bloodstream translocation, remain poorly understood. Here, we performed a genome-wide association study (GWAS) of 736 whole-genome sequences of fecal and bloodstream E. faecalis isolates from hospitalized and nonhospitalized individuals, respectively, to identify E. faecalis genetic signatures associated with the patient's hospitalization status and body isolation source...
October 9, 2023: Microbiology Spectrum
https://read.qxmd.com/read/37763237/selection-and-characterization-of-bacteriocinogenic-lactic-acid-bacteria-from-the-intestine-of-gilthead-seabream-sparus-aurata-and-whiting-fish-merlangius-merlangus-promising-strains-for-aquaculture-probiotic-and-food-bio-preservation
#22
JOURNAL ARTICLE
Sarah Cheriet, Sana Lengliz, Amel Romdhani, Paul Hynds, Mohamed Salah Abbassi, Taoufik Ghrairi
This study sought to evaluate the probiotic properties and the food preservation ability of lactic acid bacteria isolates collected from the intestines of wild marine fishes (gilthead seabream ( Sparus aurata ) ( n = 60) and whiting fish ( Merlangius merlangus ) ( n = 40)) from the Mediterranean sea in the area of Mostaganem city, Algeria. Forty-two isolates were identified as: Enterococcus durans ( n = 19), Enterococcus faecium ( n = 15), Enterococcus faecalis ( n = 4), Lactococcus lactis subp. lactis ( n = 3), and Lactobacillus plantarum ( n = 1)...
August 30, 2023: Life
https://read.qxmd.com/read/37745448/-streptococcus-mutans-inhibits-the-growth-of-enterococcus-via-the-non-ribosomal-cyclic-peptide-mutanobactin
#23
Ethan B Robertson, Julia L E Willett
UNLABELLED: Enterococcus faecalis is a Gram-positive commensal bacterium in the gastrointestinal tract and an opportunistic pathogen. Enterococci are a leading cause of nosocomial infections, treatment of which is complicated by intrinsic and acquired antibiotic resistance mechanisms. Additionally, E. faecalis has been associated with various oral diseases, and it is frequently implicated in the failure of endodontic treatment. For establishment and persistence in a microbial community, E...
September 12, 2023: bioRxiv
https://read.qxmd.com/read/37683835/enterococcus-faecalis-in-secondary-apical-periodontitis-mechanisms-of-bacterial-survival-and-disease-persistence
#24
REVIEW
Mohamed M Elashiry, Brian E Bergeron, Franklin R Tay
Enterococcus faecalis is a commensal bacterium commonly found in the human gastrointestinal tract. However, in individuals with compromised immune systems, the pathogen can lead to severe illness. This opportunistic pathogen is associated with secondary apical diseases and is adept at resisting antibiotics and other forms of treatment because of its numerous virulence factors. Enterococcus faecalis is capable of disrupting the normal functions of immune cells, thereby hindering the body's ability to eradicate the infection...
September 6, 2023: Microbial Pathogenesis
https://read.qxmd.com/read/37627663/the-emergence-of-antimicrobial-resistance-and-virulence-characteristics-in-enterococcus-species-isolated-from-bovine-milk
#25
JOURNAL ARTICLE
Beatriz Rizzo Paschoalini, Karen Vanessa Munive Nuñez, Juliana Takahashi Maffei, Hélio Langoni, Felipe Freitas Guimarães, Clarice Gebara, Natylane Eufransino Freitas, Marcos Veiga Dos Santos, Carlos Eduardo Fidelis, Roberto Kappes, Mônica Correia Gonçalves, Nathália Cristina Cirone Silva
Enterococcus spp., including E. faecalis and E. faecium , pose risks to dairy farms as opportunistic pathogens. The study evaluates antimicrobial resistance (AMR) and virulence characteristics of Enterococcus spp. isolated from bovine milk. Bile esculin agar was used to assess 1471 milk samples, followed by colony identification, gram staining, catalase tests, and 45 °C incubation. PCR analysis targeted E. faecalis and E. faecium in characteristic Enterococcus spp. colonies, with MALDI-TOF used for negative samples...
July 28, 2023: Antibiotics
https://read.qxmd.com/read/37610102/multi-omics-analysis-revealing-the-interplay-between-gut-microbiome-and-the-host-following-opioid-use
#26
JOURNAL ARTICLE
Udhghatri Kolli, Richa Jalodia, Shamsudheen Moidunny, Praveen Kumar Singh, Yuguang Ban, Junyi Tao, Gonzalo Nathaniel Cantu, Eridania Valdes, Sundaram Ramakrishnan, Sabita Roy
Opioid crisis is an ongoing epidemic since the past several decades in the United States. Opioid use-associated microbial dysbiosis is emerging as a key regulator of intestinal homeostasis and behavioral responses to opioid. However, the mechanistic insight into the role of microbial community in modulating host response is unavailable. To uncover the role of opioid-induced dysbiosis in disrupting intestinal homeostasis we utilized whole genome sequencing, untargeted metabolomics, and mRNA sequencing to identify changes in microbiome, metabolome, and host transcriptome respectively...
December 2023: Gut Microbes
https://read.qxmd.com/read/37533458/diversity-of-streptococcus-spp-and-genomic-characteristics-of-streptococcus-uberis-isolated-from-clinical-mastitis-of-cattle-in-bangladesh
#27
JOURNAL ARTICLE
Jayedul Hassan, Md Abdus Sattar Bag, Md Wohab Ali, Ajran Kabir, M Nazmul Hoque, Muhammad Maqsud Hossain, Md Tanvir Rahman, Md Shafiqul Islam, Md Shahidur Rahman Khan
INTRODUCTION: Streptococci are the major etiology in mastitis in dairy cattle, a cause of huge economic losses in the dairy industries. This study was aimed to determine the diversity of Streptococcus spp. isolated from clinical mastitis of cattle reared in Bangladesh. METHODS: A total of 843 lactating cattle reared in four prominent dairy farms and one dairy community were purposively included in this study where 80 cattle were positive to clinical mastitis (CM) based on gross changes in the udder (redness, swelling, and sensitive udder) and/or milk (flakes and/or clots)...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/37511337/an-overview-of-the-factors-involved-in-biofilm-production-by-the-enterococcus-genus
#28
REVIEW
Pavel Șchiopu, Dan Alexandru Toc, Ioana Alina Colosi, Carmen Costache, Giuseppe Ruospo, George Berar, Ștefan-Gabriel Gălbău, Alexandra Cristina Ghilea, Alexandru Botan, Adrian-Gabriel Pană, Vlad Sever Neculicioiu, Doina Adina Todea
Enterococcus species are known for their ability to form biofilms, which contributes to their survival in extreme environments and involvement in persistent bacterial infections, especially in the case of multi-drug-resistant strains. This review aims to provide a comprehensive understanding of the mechanisms underlying biofilm formation in clinically important species such as Enterococcus faecalis and the less studied but increasingly multi-drug-resistant Enterococcus faecium , and explores potential strategies for their eradication...
July 18, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37508046/antimicrobial-resistance-profiles-virulence-determinants-and-biofilm-formation-in-enterococci-isolated-from-rhesus-macaques-macaca-mulatta-a-potential-threat-for-wildlife-in-bangladesh
#29
JOURNAL ARTICLE
Farhana Binte Ferdous, Md Saiful Islam, Md Ashek Ullah, Md Liton Rana, Sadia Afrin Punom, Fahim Haque Neloy, Mohammad Nizam Uddin Chowdhury, Jayedul Hassan, Mahbubul Pratik Siddique, Sukumar Saha, Md Tanvir Rahman
Enterococci are commensal bacteria that inhabit the digestive tracts of animals and humans. The transmission of antibiotic-resistant genes through human-animal contact poses a potential public health risk worldwide, as zoonoses from wildlife reservoirs can occur on every continent. The purpose of this study was to detect Enterococcus spp. in rhesus macaques ( Macaca mulatta ) and to investigate their resistance patterns, virulence profiles, and biofilm-forming ability. Conventional screening of rectal swabs ( n = 67) from macaques was followed by polymerase chain reaction (PCR)...
July 11, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/37370411/analysis-of-antibiotic-resistant-and-virulence-genes-of-enterococcus-detected-in-calf-colostrum-one-health-perspective
#30
JOURNAL ARTICLE
Sandra Cunha, Carla Miranda, Ângela Martins, Rúben Soares, Manuel Maia, Filipe Silva, Gilberto Igrejas, Patrícia Poeta
Enterococci are considered among the most prevalent global multidrug-resistant microorganisms globally. Their dissemination is a global concern, particularly by food-producing animals for both animals and humans. The aim of this study was to identify the species and investigate the antibiotic resistance and virulence profile of Enterococcus in bovine colostrum. Out of 88 presumptive Enterococcus isolates, species identification and susceptibility to 14 antimicrobials were tested using the disk diffusion method...
June 7, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/37370300/antibiotic-susceptibility-patterns-and-virulence-associated-factors-of-vancomycin-resistant-enterococcal-isolates-from-tertiary-care-hospitals
#31
JOURNAL ARTICLE
Arockia Doss Susai Backiam, Senbagam Duraisamy, Palaniyandi Karuppaiya, Senthilkumar Balakrishnan, Balaji Chandrasekaran, Anbarasu Kumarasamy, Amutha Raju
This study explored the prevalence of multi-drug resistance and virulence factors of enterococcal isolates obtained from various clinical specimens ( n = 1575) including urine, blood, pus, tissue, catheter, vaginal wash, semen, and endotracheal secretions. Out of 862 enterococcal isolates, 388 (45%), 246 (29%), 120 (14%), and 108 (13%) were identified as Enterococcus faecalis , Enterococcus faecium , Enterococcus durans , and Enterococcus hirae , respectively, using standard morphological and biochemical methods...
May 29, 2023: Antibiotics
https://read.qxmd.com/read/37326020/structural-insights-into-cody-activation-and-dna-recognition
#32
JOURNAL ARTICLE
Tobias Hainzl, Mari Bonde, Fredrik Almqvist, Jörgen Johansson, A Elisabeth Sauer-Eriksson
Virulence factors enable pathogenic bacteria to infect host cells, establish infection, and contribute to disease progressions. In Gram-positive pathogens such as Staphylococcus aureus (Sa) and Enterococcus faecalis (Ef), the pleiotropic transcription factor CodY plays a key role in integrating metabolism and virulence factor expression. However, to date, the structural mechanisms of CodY activation and DNA recognition are not understood. Here, we report the crystal structures of CodY from Sa and Ef in their ligand-free form and their ligand-bound form complexed with DNA...
June 16, 2023: Nucleic Acids Research
https://read.qxmd.com/read/37268049/cinnamaldehyde-inhibits-enterococcus-faecalis-biofilm-formation-and-promotes-clearance-of-its-colonization-by-modulation-of-phagocytes-in-vitro
#33
JOURNAL ARTICLE
Balasubramanian Sennammal Akshaya, Kumar Premraj, Christian Iswarya, Suganthi Muthusamy, Hairul-Islam Mohamed Ibrahim, Hany Ezzat Khalil, Vaishnavi Gunasekaran, Sundaram Vickram, Venugopal Senthil Kumar, Senthilkumar Palanisamy, Krishnaraj Thirugnanasambantham
The nosocomial pathogen, Enterococcus faecalis plays a crucial role in the pathogenesis of variety of infections including endocarditis, urinary tract, and recurrent root canal infections. Primary virulence factors of E. faecalis such as biofilm formation, gelatinase production and suppression of host innate immune response can severely harm host tissue. Thus, novel treatments are needed to prevent E. faecalis biofilm development and pathogenicity due to the worrisome rise in enterococcal resistance to antibiotics...
May 31, 2023: Microbial Pathogenesis
https://read.qxmd.com/read/37237883/natural-antimicrobials-promote-the-anti-oxidative-inhibition-of-cox-2-mediated-inflammatory-response-in-primary-oral-cells-infected-with-staphylococcus-aureus-streptococcus-pyogenes-and-enterococcus-faecalis
#34
JOURNAL ARTICLE
Eugenia Butucel, Igori Balta, Iulia Adelina Bundurus, Cosmin Alin Popescu, Tiberiu Iancu, Adelina Venig, Ioan Pet, Ducu Stef, David McCleery, Lavinia Stef, Nicolae Corcionivoschi
Staphylococcus aureus , Streptococcus pyogenes and Enterococcus faecalis can colonize the tooth root canals, adhere to dentin walls, and frequently cause periodontitis in dogs. Bacterial periodontal diseases are common in domesticated pets, causing severe oral cavity inflammation and a strong immune response. This study investigates the antioxidant effect of a natural antimicrobial mixture (Auraguard-Ag) on the ability of S. aureus , S. pyogenes and E. faecalis to infect primary canine oral epithelial cells as well as its impact on their virulence factors...
April 28, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/37235330/differences-in-virulence-factors-and-antimicrobial-susceptibility-of-uropathogenic-enterococcus-spp-strains-in-a-rural-area-of-uganda-and-a-spanish-secondary-hospital
#35
JOURNAL ARTICLE
Félix Carrasco Calzada, John Jairo Aguilera, Jaime Esteban Moreno, Juan Cuadros González, David Roca Biosca, Laura Prieto-Pérez, Ramón Pérez-Tanoira
Enterococcus faecalis and Enterococcus faecium have become two of the most important agents of nosocomial diseases due to their constantly growing resistance. Enterococcal infections are associated with biofilms, which are intrinsically sensitive to antimicrobials. The main goal of this study was to compare and relate their capacity to form biofilm and their antimicrobial sensitivity, as well as their virulence factors and their implicated genes, of strains isolated from patients with urinary tract infection (UTI) in a rural hospital in Uganda and a secondary hospital in Spain...
May 16, 2023: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/37120759/a-highly-substituted-ring-fused-2-pyridone-compound-targeting-prfa-and-the-efflux-regulator-brta-in-listeria-monocytogenes
#36
JOURNAL ARTICLE
Hasan Tükenmez, Pardeep Singh, Souvik Sarkar, Melike Çakır, Ana H Oliveira, Cecilia Lindgren, Karolis Vaitkevicius, Mari Bonde, A Elisabeth Sauer-Eriksson, Fredrik Almqvist, Jörgen Johansson
Listeria monocytogenes is a facultative Gram-positive bacterium that causes listeriosis, a severe foodborne disease. We previously discovered that ring-fused 2-pyridone compounds can decrease virulence factor expression in Listeria by binding and inactivating the PrfA virulence activator. In this study, we tested PS900, a highly substituted 2-pyridone that was recently discovered to be bactericidal to other Gram-positive pathogenic bacteria, such as Staphylococcus aureus and Enterococcus faecalis. We show that PS900 can interact with PrfA and reduce the expression of virulence factors...
April 25, 2023: MBio
https://read.qxmd.com/read/37111509/urinary-tract-infections-the-current-scenario-and-future-prospects
#37
REVIEW
Giuseppe Mancuso, Angelina Midiri, Elisabetta Gerace, Maria Marra, Sebastiana Zummo, Carmelo Biondo
Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, occurring in both community and healthcare settings. Although the clinical symptoms of UTIs are heterogeneous and range from uncomplicated (uUTIs) to complicated (cUTIs), most UTIs are usually treated empirically. Bacteria are the main causative agents of these infections, although more rarely, other microorganisms, such as fungi and some viruses, have been reported to be responsible for UTIs. Uropathogenic Escherichia coli (UPEC) is the most common causative agent for both uUTIs and cUTIs, followed by other pathogenic microorganisms, such as Klebsiella pneumoniae , Proteus mirabilis , Enterococcus faecalis, and Staphylococcus spp...
April 20, 2023: Pathogens
https://read.qxmd.com/read/37110286/effect-of-ph-norepinephrine-and-glucose-on-metabolic-and-biofilm-activity-of-uropathogenic-microorganisms
#38
JOURNAL ARTICLE
Nadezhda Ignatova, Alina Abidullina, Olga Streltsova, Vadim Elagin, Vladislav Kamensky
Urinary tract infection (UTIs) aremainly caused by a number of anatomical and physiological dysfunctions, but there are also some iatrogenic factors, including the use of certain medications, that contribute to the development of UTIs. The virulence of bacteria that colonize the urinary tract may be modified by pH and by the presence of soluble substances in urine, such as norepinephrine (NE) and glucose. In this work, we studied the influence of NE and glucose across a range of pHs (5, 7, 8) on the biomass, matrix production and metabolism of uropathogenic strains of Escherichia coli , Pseudomonas aeruginosa , Klebsiella pneumoniae , Staphylococcus aureus and Enterococcus faecalis ...
March 28, 2023: Microorganisms
https://read.qxmd.com/read/37096826/pathogen-induced-dormancy-in-liquid-limits-gastrointestinal-colonization-of-caenorhabditis-elegans
#39
JOURNAL ARTICLE
Liyang Zhang, Vyshnavi Gade, Natalia V Kirienko
Colonization is generally considered a prerequisite for infection, but this event is context-dependent, as evidenced by the differing ability of the human pathogen Pseudomonas aeruginosa to efficiently colonize Caenorhabditis elegans on agar but not in liquid . In this study, we examined the impact of the environment, pathogen, host, and their interactions on host colonization. We found that the transition to a liquid environment reduces food uptake by about two-fold. Also expression of specific adhesins was significantly altered in liquid-based assays for P...
December 2023: Virulence
https://read.qxmd.com/read/36977666/butyrate-potentiates-enterococcus-faecalis-lipoteichoic-acid-induced-inflammasome-activation-via-histone-deacetylase-inhibition
#40
JOURNAL ARTICLE
Ok-Jin Park, Ye-Eun Ha, Ju-Ri Sim, Dongwook Lee, Eun-Hye Lee, Sun-Young Kim, Cheol-Heui Yun, Seung Hyun Han
Enterococcus faecalis, a Gram-positive opportunistic pathogen having lipoteichoic acid (LTA) as a major virulence factor, is closely associated with refractory apical periodontitis. Short-chain fatty acids (SCFAs) are found in the apical lesion and may affect inflammatory responses induced by E. faecalis. In the current study, we investigated inflammasome activation by E. faecalis LTA (Ef.LTA) and SCFAs in THP-1 cells. Among SCFAs, butyrate in combination with Ef.LTA markedly enhanced caspase-1 activation and IL-1β secretion whereas these were not induced by Ef...
March 28, 2023: Cell Death Discovery
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