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enterococcus faecalis virulence factors

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https://www.readbyqxmd.com/read/28584459/susceptibility-pattern-of-enterococci-at-tertiary-care-hospital
#1
Sadhana Sachan, Vinita Rawat, Umesh, Mukesh Kumar, Tripta Kaur, Preeti Chaturvedi
The study was aimed to characterize enterococci from various clinical specimens, to determine the antimicrobial susceptibility pattern, and to explore the association between virulence factors and antimicrobial resistance. A total of 283 clinical enterococcal isolates were speciated and subjected to antimicrobial susceptibility testing. Virulence factors (hemolysin, gelatinase, and biofilm production) were detected phenotypically. Of the 283 enterococci isolated, 12 species were identified; predominant species were Enterococcus faecalis (82...
April 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/28578090/genotyping-antimicrobial-resistance-and-virulence-factor-gene-profiles-of-vancomycin-resistance-enterococcus-faecalis-isolated-from-blood-culture
#2
Shahnaz Armin, Fatemeh Fallah, Abdollah Karimi, Marjan Rashidan, Mehdi Shirdust, Leila Azimi
BACKGROUND: Enterococcus spp. is the common of intestinal micro flora in humans but nowadays this gram-positive bacterium causes the variety of nosocomial infections. Resistance to antibiotic and also, presence of different virulence genes in the enterococcus spp. can change it to problematic microorganisms in the health care centers. The aim of this study was determined the genotyping, antimicrobial resistance and virulence factor gene profiles of vancomycin resistance Enterococcus faecalis isolated from blood culture...
May 31, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28567146/virulence-factors-associated-with-enterococcus-faecalis-infective-endocarditis-a-mini-review
#3
REVIEW
Kristian T Madsen, Marianne N Skov, Sabine Gill, Michael Kemp
INTRODUCTION: The enterococci are accountable for up to 20% of all cases of infective endocarditis, with Enterococcus faecalis being the primary causative isolate. Infective endocarditis is a life-threatening infection of the endocardium that results in the formation of vegetations. Based on a literature review, this paper provides an overview of the virulence factors associated with E. faecalis infective endocarditis. Furthermore, it reports the effects of active or passive immunization against some of these involved factors...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/28566074/-evaluation-of-virulence-factors-in-enterococcus-species
#4
Ergun Mete, İlknur Kaleli, Nural Cevahir, Melek Demir, Yüksel Akkaya, Özgün Kiriş Satılmış
Enterococci have recently become important due to their increased isolation rates in community-based and nosocomial infections and resistance to many antibiotics, including glycopeptides. The aim of this study was to evaluate the antimicrobial susceptible patterns and virulence factors of various clinical specimens; urine (n= 149), blood (n= 38), wound (n= 17), stool (n= 13), and other (n= 12) with a total of 229 enterococci including 138 E.faecalis and 91 E.faecium isolates. Aggregation factor (AF), enterococcus surface protein (esp), cytolysins and gelatinase encoding genes (asa1, esp, cylM, cylBcyl A, cylll, cylls, gelE, respectively) were investigated by molecular methods...
April 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28536572/the-bacteriophage-ef-p29-efficiently-protects-against-lethal-vancomycin-resistant-enterococcus-faecalis-and-alleviates-gut-microbiota-imbalance-in-a-murine-bacteremia-model
#5
Mengjun Cheng, Jiaming Liang, Yufeng Zhang, Liyuan Hu, Pengjuan Gong, Ruopeng Cai, Lei Zhang, Hao Zhang, Jinli Ge, Yalu Ji, Zhimin Guo, Xin Feng, Changjiang Sun, Yongjun Yang, Liancheng Lei, Wenyu Han, Jingmin Gu
Enterococcus faecalis is becoming an increasingly important opportunistic pathogen worldwide, especially because it can cause life-threatening nosocomial infections. Treating E. faecalis infections has become increasingly difficult because of the prevalence of multidrug-resistant E. faecalis strains. Because bacteriophages show specificity for their bacterial hosts, there has been a growth in interest in using phage therapies to combat the rising incidence of multidrug-resistant bacterial infections. In this study, we isolated a new lytic phage, EF-P29, which showed high efficiency and a broad host range against E...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28467378/molecular-mechanism-of-quorum-sensing-in-enterococcus-faecalis-its-role-in-virulence-and-therapeutic-approaches
#6
REVIEW
Liaqat Ali, Mohsan Ullah Goraya, Yasir Arafat, Muhammad Ajmal, Ji-Long Chen, Daojin Yu
Quorum-sensing systems control major virulence determinants in Enterococcusfaecalis, which causes nosocomial infections. The E. faecalis quorum-sensing systems include several virulence factors that are regulated by the cytolysin operon, which encodes the cytolysin toxin. In addition, the E. faecalis Fsr regulator system controls the expression of gelatinase, serine protease, and enterocin O16. The cytolysin and Fsr virulence factor systems are linked to enterococcal diseases that affect the health of humans and other host models...
May 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28384222/functional-studies-of-e-faecalis-rnase-j2-and-its-role-in-virulence-and-fitness
#7
Peng Gao, Kenneth L Pinkston, Agathe Bourgogne, Barbara E Murray, Ambro van Hoof, Barrett R Harvey
Post-transcriptional control provides bacterial pathogens a method by which they can rapidly adapt to environmental change. Dual exo- and endonucleolytic activities of RNase J enzymes contribute to Gram-positive RNA processing and decay. First discovered in Bacillus subtilis, RNase J1 plays a key role in mRNA maturation and degradation, while the function of the paralogue RNase J2 is largely unknown. Previously, we discovered that deletion of the Enterococcus faecalis rnjB gene significantly attenuates expression of a major virulence factor involved in enterococcal pathogenesis, the Ebp pili...
2017: PloS One
https://www.readbyqxmd.com/read/28334141/distribution-of-antimicrobial-resistance-determinants-virulence-associated-factors-and-clustered-regularly-interspaced-palindromic-repeats-loci-in-isolates-of-enterococcus-faecalis-from-various-settings-and-genetic-lineages
#8
Iwona Gawryszewska, Katarzyna Malinowska, Alicja Kuch, Dorota Chrobak-Chmiel, Lucja Laniewska- Trokenheim, Waleria Hryniewicz, Ewa Sadowy
Enterococcus faecalis represents an important factor of hospital-associated infections (HAIs). The knowledge on its evolution from a commensal to an opportunistic pathogen is still limited; thus, we performed a study to characterise distribution of factors that may contribute to this adaptation. Using a collection obtained from various settings (hospitalised patients, community carriers, animals, fresh food, sewage, water), we investigated differences in antimicrobial susceptibility, distribution of antimicrobial resistance genes, virulence-associated determinants and phenotypes, and CRISPR loci in the context of the clonal relatedness of isolates...
March 1, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28332345/high-incidence-of-virulence-factors-among-clinical-enterococcus-faecalis-isolates-in-southwestern-iran
#9
Hamid Heidari, Somayeh Hasanpour, Hadi Sedigh Ebrahim-Saraie, Mohammad Motamedifar
BACKGROUND: Over the past two decades, enterococci have emerged as an important agent responsible for hospital acquired infection. Several virulence factors contribute to the adherence, colonization, evasion of the host immune response, and pathogenicity and severity of the infection. Enterococcus faecalis is the most common and virulent species causing infections in hospitalized patients. The aim of the present study was to examine the prevalence of genes encoding virulence factors and antimicrobial resistance patterns of E...
March 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28316009/safety-assessment-of-commensal-enterococci-from-dogs
#10
Ivana Kubašová, Viola Strompfová, Andrea Lauková
Enterococci form a complex, diverse, and very important group of bacteria from the technological and food safety aspect, or from the health-improving aspect as probiotics. Generally, enterococci are considered to be of low pathogenic potential, which is associated mostly with clinical strains. In these strains, production of virulence factors as well as resistance to many antimicrobial drugs could complicate treatment of nosocomial infections. Because there is a lack of information on incidence of these attributes in animal commensal enterococci, we screened 160 strains originating from feces of clinically healthy dogs in Eastern Slovakia (n = 105)...
March 18, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28270110/comparative-genomics-of-enterococcus-spp-isolated-from-bovine-feces
#11
Alicia G Beukers, Rahat Zaheer, Noriko Goji, Kingsley K Amoako, Alexandre V Chaves, Michael P Ward, Tim A McAllister
BACKGROUND: Enterococcus is ubiquitous in nature and is a commensal of both the bovine and human gastrointestinal (GI) tract. It is also associated with clinical infections in humans. Subtherapeutic administration of antibiotics to cattle selects for antibiotic resistant enterococci in the bovine GI tract. Antibiotic resistance genes (ARGs) may be present in enterococci following antibiotic use in cattle. If located on mobile genetic elements (MGEs) their dissemination between Enterococcus species and to pathogenic bacteria may be promoted, reducing the efficacy of antibiotics...
March 8, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28258002/molecular-assessment-of-virulence-determinants-hospital-associated-marker-is16gene-and-prevalence-of-antibiotic-resistance-in-soil-borne-enterococcus-species
#12
Syed Abid Ali, Hassan Bin-Asif, Khwaja Ali Hasan, Marium Rehman, Atiya Abbasi
Enterococci, no more regarded as GRAS (Generally Recognized As Safe) organism, are emerging as an important source of nosocomial infections worldwide. The main contributors in pathogenesis of enterococci are the presence of various virulent factors and antibiotic resistance genes. We aimed to examine the prevalence, dissemination, antibiotic resistance and virulent factors associated with enterococci from bulk soil (BS). A total of 372 enterococci were isolated from 500 soil samples. PCR was used to identify the isolates up to species level and for carriage of 16 virulence genes including hospital associated marker (i...
April 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28184339/correlation-between-infective-factors-and-antibiotic-resistance-in-enterococci-clinical-isolates-in-west-of-iran
#13
Mohammad Reza Arabestani, Mona Nasaj, Seyed Masoud Mousavi
The present study was done to scrutinize the possible relation between infective genes and antimicrobial resistance in Enterococcus faecalis and Enterococcus faecium. Considering the fact that the presence of recognized infective determinants among clinical isolates may promote the emergence of infections and persistence of Enterococci in hospital settings, which can lead to an increase in antimicrobial resistance. 175 E. faecalis and 67 E. faecium isolated from clinical specimens were used. The isolates were identified, and then antibiotic susceptibility testing was performed...
January 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/28081148/characterization-of-multi-drug-resistant-enterococcus-faecalis-isolated-from-cephalic-recording-chambers-in-research-macaques-macaca-spp
#14
Stephanie E Woods, Mia T Lieberman, Francois Lebreton, Elise Trowel, César de la Fuente-Núñez, Joanne Dzink-Fox, Michael S Gilmore, James G Fox
Nonhuman primates are commonly used for cognitive neuroscience research and often surgically implanted with cephalic recording chambers for electrophysiological recording. Aerobic bacterial cultures from 25 macaques identified 72 bacterial isolates, including 15 Enterococcus faecalis isolates. The E. faecalis isolates displayed multi-drug resistant phenotypes, with resistance to ciprofloxacin, enrofloxacin, trimethoprim-sulfamethoxazole, tetracycline, chloramphenicol, bacitracin, and erythromycin, as well as high-level aminoglycoside resistance...
2017: PloS One
https://www.readbyqxmd.com/read/27965638/functional-characterization-of-triclosan-resistant-enoyl-acyl-carrier-protein-reductase-fabv-in-pseudomonas-aeruginosa
#15
Yong-Heng Huang, Jin-Shui Lin, Jin-Cheng Ma, Hai-Hong Wang
Pseudomonas aeruginosa is extremely resistant to triclosan. Previous studies have shown that P. aeruginosa encodes a triclosan-resistant enoyl-acyl-carrier protein reductase (ENR), FabV, and that deletion of fabV causes P. aeruginosa to be extremely sensitive to triclosan. In this report, we complemented a P. aeruginosa fabV deletion strain with several triclosan-resistant ENR encoding genes, including Vibrio cholerae fabV, Bacillus subtilis fabL and Enterococcus faecalis fabK. All complemented strains restored triclosan resistance to the level of the wild-type strain, which confirmed that triclosan-resistant ENR allows P...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27924153/genome-sequence-of-a-commensal-bacterium-enterococcus-faecalis-cba7120-isolated-from-a-korean-fecal-sample
#16
Joon Yong Kim, Hye Seon Song, Yeon Bee Kim, Joseph Kwon, Jong-Soon Choi, Yong-Joon Cho, Byung-Yong Kim, Jin-Kyu Rhee, Jinjong Myoung, Young-Do Nam, Seong Woon Roh
BACKGROUND: Enterococcus faecalis, the type strain of the genus Enterococcus, is not only a commensal bacterium in the gastrointestinal tract in vertebrates and invertebrates, but also causes serious disease as an opportunistic pathogen. To date, genome sequences have been published for over four hundred E. faecalis strains; however, pathogenicity of these microbes remains complicated. To increase our knowledge of E. faecalis virulence factors, we isolated strain CBA7120 from the feces of an 81-year-old female from the Republic of Korea and performed a comparative genomic analysis...
2016: Gut Pathogens
https://www.readbyqxmd.com/read/27790716/characterization-of-antimicrobial-resistance-and-quinolone-resistance-factors-in-high-level-ciprofloxacin-resistant-enterococcus-faecalis-and-enterococcus-faecium-isolates-obtained-from-fresh-produce-and-fecal-samples-of-patients
#17
Min-Chan Kim, Gun-Jo Woo
BACKGROUND: The emergence of fluoroquinolone-resistant enterococci is worldwide. Antimicrobial resistance was characterized and the effect of quinolone-resistance factors was analyzed in high-level ciprofloxacin-resistant (HLCR) Enterococcus faecalis and Enterococcus faecium isolated from fresh produce and fecal samples of patients. RESULTS: Among the 81 ciprofloxacin-resistant Enterococcus isolates, 46 showed high levels of ciprofloxacin resistance, resistance to other quinolone antibiotics, and multidrug resistance profiles...
October 28, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27648425/prevalence-of-virulence-factors-and-vancomycin-resistant-genes-among-enterococcus-faecalis-and-e-faecium-isolated-from-clinical-specimens
#18
Mona Nasaj, Seyed Masoud Mousavi, Seyed Mostafa Hosseini, Mohammad Reza Arabestani
BACKGROUND: The aim of this study was to determine the occurrence of virulence determinants and vancomycin-resistant genes among Enterococcus faecalis and E. faecium obtained from various clinical sources. METHODS: The study was performed on the 280 enterococcal isolated from clinical specimens in Hamadan hospitals, western Iran in 2012-14. Antibiotic susceptibility testing was performed using disk diffusion and Minimal Inhibitory Concentration (MIC) methods. The presence of vancomycin-resistant genes and virulence genes was investigated using PCR...
June 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27631785/enterococcus-species-in-the-oral-cavity-prevalence-virulence-factors-and-antimicrobial-susceptibility
#19
Edson Yukio Komiyama, Laura Soares Souto Lepesqueur, Cinthia Gomes Yassuda, Lakshman P Samaranayake, Nipuna B Parahitiyawa, Ivan Balducci, Cristiane Yumi Koga-Ito
Enterococci are considered as transient constituent components of the oral microbiome that may cause a variety of oral and systemic infections. As there is sparse data on the oral enterococcal prevalence, we evaluated the Enterococcus spp. and their virulence attributes including antimicrobial resistance in a healthy Brazilian cohort. A total of 240 individuals in different age groups were studied (children 4-11 yrs, adolescents 12-17 yrs, young adults 18-29 yrs, adults 30-59 yrs, elderly over 60 yrs). Oral rinses were collected and isolates were identified by API 20 Strep and confirmed by 16S rDNA sequencing...
2016: PloS One
https://www.readbyqxmd.com/read/27520407/sodium-hypochlorite-inactivates-lipoteichoic-acid-of-enterococcus-faecalis-by-deacylation
#20
Sun Woong Hong, Jung Eun Baik, Seok-Seong Kang, Kee-Yeon Kum, Cheol-Heui Yun, Seung Hyun Han
INTRODUCTION: Enterococcus faecalis is a pathogenic gram-positive bacterium closely associated with apical periodontitis. Although sodium hypochlorite (NaOCl) has been used as a common endodontic irrigant to eradicate bacteria in the root canal, it has not been elucidated whether NaOCl attenuates the inflammatory response induced by the E. faecalis virulence factor lipoteichoic acid (EfLTA). METHODS: Structurally intact EfLTA purified from E. faecalis was treated with NaOCl at various concentrations and time periods...
October 2016: Journal of Endodontics
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