Adam X Maihofer, Andrew Ratanatharathorn, Sian M J Hemmings, Karen H Costenbader, Vasiliki Michopoulos, Renato Polimanti, Alex O Rothbaum, Soraya Seedat, Elizabeth A Mikita, Alicia K Smith, Rany M Salem, Richard A Shaffer, Tianying Wu, Jonathan Sebat, Kerry J Ressler, Murray B Stein, Karestan C Koenen, Erika J Wolf, Jennifer A Sumner, Caroline M Nievergelt
Observational studies suggest that posttraumatic stress disorder (PTSD) increases risk for various autoimmune diseases. Insights into shared biology and causal relationships between these diseases may inform intervention approaches to PTSD and co-morbid autoimmune conditions. We investigated the shared genetic contributions and causal relationships between PTSD, 18 autoimmune diseases, and 3 immune/inflammatory biomarkers. Univariate MiXeR was used to contrast the genetic architectures of phenotypes. Genetic correlations were estimated using linkage disequilibrium score regression...
April 1, 2024: Translational Psychiatry