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autoimmune thyroid diseases

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https://www.readbyqxmd.com/read/27906879/presence-of-organ%C3%A2-specific-antibodies-in-patients-with-systemic-sclerosis
#1
Ewa Wielosz, Maria Majdan, Arkadiusz Koszarny, Magdalena Dryglewska, Jacek Tabarkiewicz
INTRODUCTION According to the literature, organ‑specific antibodies may be present in the course of systemic sclerosis (SSc). OBJECTIVES The aim of this study was to assess the prevalence of antithyroid antibodies (antithyroid peroxidase antibodies [anti‑TPO] and antithyroglobulin antibodies) and of antimitochondrial antibodies (AMAs), as well as to evaluate their clinical significance in patients with SSc. PATIENTS AND METHODS The study involved 86 consecutive in‑hospital patients with SSc (32 patients with diffuse cutaneous SSc [dcSSc] and 54 with limited cutaneous SSc [lcSSc])...
October 5, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27906181/stat6-deficiency-ameliorates-graves-disease-severity-by-suppressing-thyroid-epithelial-cell-hyperplasia
#2
Xuechao Jiang, Bingbing Zha, Xiaoming Liu, Ronghua Liu, Jun Liu, Enyu Huang, Tingting Qian, Jiajing Liu, Zhiming Wang, Dan Zhang, Luman Wang, Yiwei Chu
Signal transducer and activator of transcription 6 (STAT6) is involved in epithelial cell growth. However, little is known regarding the STAT6 phosphorylation status in Graves' disease (GD) and its role in thyroid epithelial cells (TECs). In this study, we found that STAT6 phosphorylation (p-STAT6) was significantly increased in TECs from both GD patients and experimental autoimmune Graves' disease mice and that STAT6 deficiency ameliorated GD symptoms. Autocrine IL-4 signalling in TECs activated the phosphorylation of STAT6 via IL-4 R engagement, and the downstream targets of STAT6 were Bcl-xL and cyclin D1...
December 1, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27905199/high-prevalence-of-anti-tsh-receptor-antibody-in-fibromyalgia-syndrome
#3
Kenya Nishioka, Toyoyoshi Uchida, Chie Usui, Ryota Tanaka, Takashi Matsushima, Yoshifuji Matsumoto, Ikuro Nakamura, Kusuki Nishioka, Nobutaka Hattori
AIM: Fibromyalgia syndrome (FMS) is defined as chronic widespread pain that cannot be accounted for by any other medical disorder. Our aim was to explore the prevalence of thyroid autoimmunity in patients with FMS. METHODS: For determining thyroid function in 207 FMS patients, we tested for the titers of free tri-iodothyronine, free thyroxine, thyroid-stimulating hormone (TSH), anti-thyroid peroxidase antibody (TPOAb), anti-thyroglobulin antibody (TgAb) and anti-TSH receptor antibody (TRAb)...
November 30, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/27901180/ultrasonographic-assessment-of-thyroid-volume-in-oldest-old-individuals
#4
Glaucia Cruzes Duarte, Lara Miguel Quirino Araujo, Felix Magalhães, Clineu Mello Almada, Maysa Seabra Cendoroglo
Objective: The aim of this study was to describe the relationship between thyroid volume and age, gender, anthropometric characteristics, and echogenicity in oldest-old subjects in an iodine-sufficient area. Subjects and methods: The study included 81 independent elderly individuals aged ≥ 80 years (65 [80.2%] women). We determined these individuals' anthropometric characteristics, body mass index (BMI), and lean body mass, as well as thyroid volume and echogenicity by ultrasonography...
November 24, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27895620/excessive-cytosolic-dna-fragments-as-a-potential-trigger-of-graves-disease-an-encrypted-message-sent-by-animal-models
#5
REVIEW
Yuqian Luo, Aya Yoshihara, Kenzaburo Oda, Yuko Ishido, Koichi Suzuki
Graves' hyperthyroidism is caused by autoantibodies directed against the thyroid-stimulating hormone receptor (TSHR) that mimic the action of TSH. The establishment of Graves' hyperthyroidism in experimental animals has proven to be an important approach to dissect the mechanisms of self-tolerance breakdown that lead to the production of thyroid-stimulating TSHR autoantibodies (TSAbs). "Shimojo's model" was the first successful Graves' animal model, wherein immunization with fibroblasts cells expressing TSHR and a major histocompatibility complex (MHC) class II molecule, but not either alone, induced TSAb production in AKR/N (H-2(k)) mice...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27894748/ccr5-%C3%AE-32-gene-polymorphism-is-related-to-celiac-disease-and-autoimmune-thyroiditis-coincidence-in-patients-with-type-1-diabetes
#6
Bartosz Słomiński, Urszula Ławrynowicz, Jolanta Myśliwska, Monika Ryba-Stanisławowska, Maria Skrzypkowska, Małgorzata Myśliwiec, Agnieszka Brandt
AIM: The aim of the study was to assess the relationship between CCR5-Δ32 polymorphism and the coincidence of celiac and autoimmune thyroid diseases with type 1 diabetes mellitus (T1D) in children. METHODS: 420 children with T1D aged 15.5±3.0years and 350 healthy controls were studied. Characterization of CCR5-Δ32 genotypes (rs333) was analyzed by polymerase chain reaction (PCR). RESULTS: The allele frequency was significantly different in diabetic children as compared to the healthy controls (p<0...
November 3, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27892628/association-between-foxp3-gene-polymorphisms-and-risk-of-differentiated-thyroid-cancer-in-chinese-han-population
#7
Weichao Jiang, Lei Zheng, Lijuan Xu, Yang Zhang, Xingxin Liu, Lihua Hu, Xiaobei Wang
BACKGROUND: Foxp3 plays important roles in autoimmune and inflammatory diseases as well as human malignancies. This study aimed to investigate the association between Foxp3 gene polymorphisms and the susceptibility to differentiated thyroid cancers (DTC). METHODS: Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 350 DTC patients and 306 healthy controls. FOXP3 relative expression was measured by real-time quantitative PCR (qRT-PCR)...
November 28, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27891401/premature-ovarian-failure-an-association-with-autoimmune-diseases
#8
Ayesha, Vandana Jha, Deepti Goswami
INTRODUCTION: Premature Ovarian Failure (POF) is the cessation of ovarian function before the age of 40 years. POF is reported to be associated with autoimmune diseases in 20-30% of cases. AIM: Patients presenting with idiopathic POF were screened for the presence of autoimmune disorders. MATERIALS AND METHODS: Twenty patients with idiopathic POF were included in the study. Baseline investigation in all subjects included fasting serum FSH, LH, E2, progesterone, free T3, free T4, Thyroid-Stimulating Hormone (TSH) and Anti-Thyroperoxidase (anti-TPO) antibodies, testosterone and Dehydroepiandrosterone (DHEAS) levels...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889732/distal-renal-tubular-acidosis-associated-with-celiac-disease-and-thyroiditis
#9
Amit Kumar Satapathy, Sapna Mittal, Vandana Jain
BACKGROUND: Association of distal renal tubular acidosis (RTA) with autoimmune diseases is extremely rare in children. CASE CHARACTERISTICS: 12-year-old girl with distal RTA. Despite resolution of acidosis on bicarbonate, she continued to have poor growth and delayed puberty. Investigations revealed autoimmune thyroiditis and celiac disease. OUTCOME: Levothyroxine and gluten-free diet were initiated. Child gained height and weight and had onset of puberty after gluten withdrawal...
November 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27888002/polymorphisms-in-mir499a-and-mir125a-gene-are-associated-with-autoimmune-thyroid-diseases
#10
TianTian Cai, Jie Li, Xiaofei An, Ni Yan, Danfeng Li, Yanfei Jiang, Wen Wang, Liangfeng Shi, Qiu Qin, Ronghua Song, Guofei Wang, Wenjuan Jiang, Jin-An Zhang
BACKGROUND: Single nucleotide polymorphisms (SNPs) of the miR-146a, miR-499a and miR-125a have been shown to be associated with the susceptibility to several autoimmune diseases. This study was conducted to identify the association of SNPs rs2910164, rs57095329, rs3746444 and rs12976445 with autoimmune thyroid diseases (AITDs) in a Chinese Han population. METHODS: We enrolled 1061 patients with AITDs, including 701 patients with Graves' disease (GD) and 360 patients with Hashimoto's thyroiditis (HT), and 938 healthy individuals for a case-control genetic association study...
November 22, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27885217/lymphocytic-adrenal-medullitis-and-lymphocytic-thyroiditis-in-a-laboratory-beagle-dog
#11
Takuya Doi, Yuki Tomonari, Kazufumi Kawasako, Naoaki Yamada, Minoru Tsuchitani
Lymphocytic adrenal medullitis characterized by inflammation and atrophy in the medulla of the bilateral adrenal glands was observed in an 18-month-old male laboratory beagle dog. It might be that the present lymphocytic adrenal medullitis is an autoimmune-mediated disease as the histological characteristics are consistent with an autoimmune pathogenesis. However, the actual cause remains unclear as the existence of serum autoantibodies against the adrenal medulla could not be confirmed. Although this dog also contracted lymphocytic thyroiditis along with serum thyroglobulin autoantibodies, indicating that the thyroiditis occurred with an autoimmune basis; the relation between the adrenal medullitis and thyroiditis is unknown...
November 24, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27879326/effects-of-levothyroxine-treatment-on-pregnancy-outcomes-in-pregnant-women-with-autoimmune-thyroid-disease
#12
Sima Nazarpour, Fahimeh Ramezani Tehrani, Masoumeh Simbar, Maryam Tohidi, Hamid Alavi Majd, Fereidoun Azizi
BACKGROUND: Despite some studies indicating that thyroid antibody positivity during pregnancy has been associated with adverse pregnancy outcomes, evidence regarding the effects of levothyroxine (LT4) treatment of euthyroid/subclinical hypothyroid pregnant women with autoimmune thyroid disease on pregnancy outcome is limited. We aimed to assess whether pregnant women with autoimmune thyroid disease, but without overt thyroid dysfunction are affected by higher rates of adverse pregnancy outcomes...
November 22, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27869686/the-association-of-serum-bisphenol-a-with-thyroid-autoimmunity
#13
La-Or Chailurkit, Wichai Aekplakorn, Boonsong Ongphiphadhanakul
Introduction: Data on the association of bisphenol A (BPA) exposure and autoimmunity in humans is unclear. Objective: To elucidate the influence of BPA on thyroid autoimmunity, in the present study we assessed the association between serum BPA and thyroid autoantibodies. Methods: Serum samples from 2361 subjects, aged ≥15 years, from the Thai 4th National Health Examination Survey were measured for BPA, antithyroglobulin (TgAb), antithyroperoxidase (TPOAb) and antithyrotrophin receptor (TRAb) antibodies. Results: The proportion of subjects positive for TgAb, TPOAb and TRAb were 11...
November 17, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27863461/pooled-genome-wide-association-detects-association-upstream-of-fcrl3-with-graves-disease
#14
Jwu Jin Khong, Kathryn P Burdon, Yi Lu, Kate Laurie, Lefta Leonardos, Paul N Baird, Srujana Sahebjada, John P Walsh, Adam Gajdatsy, Peter R Ebeling, Peter Shane Hamblin, Rosemary Wong, Simon P Forehan, Spiros Fourlanos, Anthony P Roberts, Matthew Doogue, Dinesh Selva, Grant W Montgomery, Stuart Macgregor, Jamie E Craig
BACKGROUND: Graves' disease is an autoimmune thyroid disease of complex inheritance. Multiple genetic susceptibility loci are thought to be involved in Graves' disease and it is therefore likely that these can be identified by genome wide association studies. This study aimed to determine if a genome wide association study, using a pooling methodology, could detect genomic loci associated with Graves' disease. RESULTS: Nineteen of the top ranking single nucleotide polymorphisms including HLA-DQA1 and C6orf10, were clustered within the Major Histo-compatibility Complex region on chromosome 6p21, with rs1613056 reaching genome wide significance (p = 5 × 10(-8))...
November 18, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27859474/polyglandular-autoimmune-syndrome-type-iii-with-a-prevalence-of-cutaneous-features
#15
A Capo, P Amerio
Polyglandular autoimmune syndrome (PAS) is the name given to a group of autoimmune disorders of the endocrine glands. PAS type III (PAS III) comprises several autoimmune diseases (autoimmune thyroiditis, immune-mediated diabetes mellitus, pernicious anaemia, vitiligo, alopecia areata and many others) and is subdivided into four subcategories. We report the case of a 52-year-old woman with autoimmune thyroiditis, vitiligo, alopecia areata, psoriasis and lichen sclerosus, suggesting a clinical diagnosis of PAS IIIC with a singular prevalence of cutaneous features...
November 13, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27857890/prevalence-of-thyroid-disorders-in-hepatitis-c-virus-positive-patients-on-interferon-and-antiviral-therapy
#16
Gitanjali Goyal, Kmds Panag, Ravinder Garg
BACKGROUND: Hepatitis C virus (HCV) infection is common worldwide. The treatment typically involves a combination of interferon-alpha (IFN-α) and ribavirin (RBV) therapy; however, the use of IFN-α is well documented to be associated with thyroid disease, the most common autoimmune disorder associated with IFN-α. AIM: The aim of the present study was to know the prevalence of thyroid abnormality in the HCV-positive patients on IFN and antiviral therapy. MATERIALS AND METHODS: Fifty known HCV positive patients were enrolled for the study...
October 2016: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/27857839/fatal-outcome-in-a-hispanic-woman-with-moyamoya-syndrome-and-graves-disease
#17
Julian Choi, Perin Suthakar, Farbod Farmand
: We describe the case of a young Hispanic female who presented with thyrotoxicosis with seizures and ischemic stroke. She was diagnosed with a rare vasculopathy - moyamoya syndrome. After starting antithyroid therapy, her neurologic symptoms did not improve. Acute neurosurgical intervention had relieved her symptoms in the immediate post-operative period after re-anastomosis surgery. However, 2 post-operative days later, she was found to be in status epilepticus and in hyperthyroid state...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27855396/imbalance-of-th17-treg-in-different-subtypes-of-autoimmune-thyroid-diseases
#18
Cui Li, Jianghong Yuan, Yuan-Feng Zhu, Xiang-Ju Yang, Qiong Wang, Jian Xu, Shuang-Tao He, Jin-An Zhang
AIMS: To clarify the imbalance of Th17/Treg in different subtypes of autoimmune thyroid diseases (AITDs) including Graves' disease(GD), Hashimoto's thyroiditis(HT) and Graves' ophthalmopathy (GO). METHODS: 47 patients with AITD (including 16 GD, 15 HT, and 16 GO) and 12 healthy controls were enrolled in this study. The percentages of Th17 and Treg cells, the ratio of Th17/Treg, as well as their related transcription factors RORγt and Foxp3 mRNA in peripheral blood mononuclear cells (PBMCs) were measured by flow cytometry and real-time quantitative PCR Results: Compared with those in control group, the percentage of CD4+IL-17+T cell(Th17) and the mRNA expression of its transcription factor RORγt were higher in PBMCs of AITDs (P<0...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27855231/association-of-newly-diagnosed-type-1-diabetes-and-autoimmune-pancreatitis
#19
Laila Ennazk, Ghizlane El Mghari, Nawal El Ansari
: Autoimmune pancreatitis is a new nosological entity in which a lymphocytic infiltration of the exocrine pancreas is involved. The concomitant onset of autoimmune pancreatitis and type 1 diabetes has been recently described suggesting a unique immune disturbance that compromises the pancreatic endocrine and exocrine functions. We report a case of type1 diabetes onset associated with an autoimmune pancreatitis in a young patient who seemed to present a type 2 autoimmune polyglandular syndrome...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27854550/expression-and-function-of-the-co-stimulatory-receptor-slamf1-is-altered-in-lymphocytes-from-patients-with-autoimmune-thyroiditis
#20
Marlen Vitales-Noyola, Ana M Ramos-Levi, Ana Serrano-Somavilla, Rebeca Hernández-Martínez, Miguel Sampedro-Nuñez, Carmelina Di Pasquale, Roberto González-Amaro, Mónica Marazuela
CONTEXT: SLAMF1 is a co-stimulatory receptor that is expressed by most immune cells. Its role in Autoimmune Thyroid Disease (AITD) is not well known. OBJECTIVE: To analyze the expression and function of the co-stimulatory receptor SLAMF1 in lymphocytes of patients with AITD. DESIGN: Cross-sectional, prospective, single-center. SETTING: Department of Endocrinology, Hospital Universitario Princesa. PATIENTS: 28 patients with AITD (17 with Graves' disease and 11 with Hashimoto's thyroiditis) and 21 controls...
November 17, 2016: Journal of Clinical Endocrinology and Metabolism
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