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https://www.readbyqxmd.com/read/27913727/regulated-complex-assembly-safeguards-the-fidelity-of-sleeping-beauty-transposition
#1
Yongming Wang, Diana Pryputniewicz-Dobrinska, Enikö Éva Nagy, Christopher D Kaufman, Manvendra Singh, Steve Yant, Jichang Wang, Anna Dalda, Mark A Kay, Zoltán Ivics, Zsuzsanna Izsvák
The functional relevance of the inverted repeat structure (IR/DR) in a subgroup of the Tc1/mariner superfamily of transposons has been enigmatic. In contrast to mariner transposition, where a topological filter suppresses single-ended reactions, the IR/DR orchestrates a regulatory mechanism to enforce synapsis of the transposon ends before cleavage by the transposase occurs. This ordered assembly process shepherds primary transposase binding to the inner 12DRs (where cleavage does not occur), followed by capture of the 12DR of the other transposon end...
December 1, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27913105/the-colors-of-paintings-and-viewers-preferences
#2
Sérgio M C Nascimento, João M M Linhares, Cristina Montagner, Catarina A R João, Kinjiro Amano, Catarina Alfaro, Ana Bailão
One hypothesis to explain the aesthetics of paintings is that it depends on the extent to which they mimic natural image statistics. In fact, paintings and natural scenes share several statistical image regularities but the colors of paintings seem generally more biased towards red than natural scenes. Is the particular option for colors in each painting, even if less naturalistic, critical for perceived beauty? Here we show that it is. In the experiments, 50 naïve observers, unfamiliar with the 10 paintings tested, could rotate the color gamut of the paintings and select the one producing the best subjective impression...
November 29, 2016: Vision Research
https://www.readbyqxmd.com/read/27906923/-out-of-the-frying-pan-but-not-into-the-fire-quantifying-commercial-cosmetic-tanning-services-in-new-zealand-to-inform-endgame-regulation
#3
Bronwen M McNoe, Anthony I Reeder
AIMS: In the context of possible regulation, to quantify and describe: (1) indoor tanning businesses in New Zealand; (2) sunbeds available for sale on Trade Me©. METHOD: In January 2016, we conducted a national audit of businesses potentially providing sunbed services (solariums, beauty-salons, hairdressers, gyms and fitness centres) to assess the availability and cost of indoor tanning services (sunbeds and spray tanning). In addition, Trade Me©, New Zealand's largest auction site for second-hand goods, was monitored for one year to determine whether ex-commercial sunbeds were being sold in the domestic market...
December 2, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27902731/queen-nefertari-the-royal-spouse-of-pharaoh-ramses-ii-a-multidisciplinary-investigation-of-the-mummified-remains-found-in-her-tomb-qv66
#4
Michael E Habicht, Raffaella Bianucci, Stephen A Buckley, Joann Fletcher, Abigail S Bouwman, Lena M Öhrström, Roger Seiler, Francesco M Galassi, Irka Hajdas, Eleni Vassilika, Thomas Böni, Maciej Henneberg, Frank J Rühli
Queen Nefertari, the favourite Royal Consort of Pharaoh Ramses II (Ancient Egypt, New Kingdom, 19th Dynasty c. 1250 BC) is famous for her beautifully decorated tomb in the Valley of the Queens. Her burial was plundered in ancient times yet still many objects were found broken in the debris when the tomb was excavated. Amongst the found objects was a pair of mummified legs. They came to the Egyptian Museum in Turin and are henceforth regarded as the remains of this famous Queen, although they were never scientifically investigated...
2016: PloS One
https://www.readbyqxmd.com/read/27898559/the-beauty-of-death
#5
Rebecca Vaglio
No abstract text is available yet for this article.
December 2016: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/27898092/transposon-mediated-generation-of-cellular-and-mouse-models-of-splicing-mutations-to-assess-the-efficacy-of-snrna-based-therapeutics
#6
Elena Barbon, Mattia Ferrarese, Laetitia van Wittenberghe, Peggy Sanatine, Giuseppe Ronzitti, Fanny Collaud, Pasqualina Colella, Mirko Pinotti, Federico Mingozzi
Disease-causing splicing mutations can be rescued by variants of the U1 small nuclear RNA (U1snRNAs). However, the evaluation of the efficacy and safety of modified U1snRNAs as therapeutic tools is limited by the availability of cellular and animal models specific for a given mutation. Hence, we exploited the hyperactive Sleeping Beauty transposon system (SB100X) to integrate human factor IX (hFIX) minigenes into genomic DNA in vitro and in vivo. We generated stable HEK293 cell lines and C57BL/6 mice harboring splicing-competent hFIX minigenes either wild type (SChFIX-wt) or mutated (SChFIXex5-2C)...
November 29, 2016: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/27895912/the-measurement-of-media-literacy-in-eating-disorder-risk-factor-research-psychometric-properties-of-six-measures
#7
Siân A McLean, Susan J Paxton, Eleanor H Wertheim
BACKGROUND: Evaluation of media literacy-based interventions for the prevention of eating disorder risk is limited by the lack of appropriate measures with established psychometric properties with which to assess change in media literacy. This study aims to fill this gap by examining the psychometric properties and use in eating disorders risk factor research of six measures of media literacy that assess media processing and critical thinking about general media and critical thinking about appearance-focused media...
2016: Journal of Eating Disorders
https://www.readbyqxmd.com/read/27895558/physics-of-the-mind
#8
Leonid I Perlovsky
Is it possible to turn psychology into "hard science"? Physics of the mind follows the fundamental methodology of physics in all areas where physics have been developed. What is common among Newtonian mechanics, statistical physics, quantum physics, thermodynamics, theory of relativity, astrophysics… and a theory of superstrings? The common among all areas of physics is a methodology of physics discussed in the first few lines of the paper. Is physics of the mind possible? Is it possible to describe the mind based on the few first principles as physics does? The mind with its variabilities and uncertainties, the mind from perception and elementary cognition to emotions and abstract ideas, to high cognition...
2016: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/27893371/efficient-high-dimensional-edge-aware-filtering
#9
Eduardo Simoes Lopes Gastal
Traditional computer graphics filters are agnostic to the concept of objects and the transition between objects (edges), but image filters need to take edges into account in order to produce high-quality, artifact-free, beautifully formed images. Eduardo S.L. Gastal's dissertation focuses on efficient algorithms for performing edge-aware image and video filtering. The techniques he describes here leverage the known relationship between edge-aware filtering and high-dimensional spaces and are capable of achieving real-time performance in high-resolution data...
November 2016: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/27892976/validation-of-a-method-for-estimation-of-facial-age-by-plastic-surgeons
#10
Denis Souto Valente, Jefferson Braga da Silva, Aline Grimaldi Lerias, Daniele Dos Santos Rossi, Alexandre Vontobel Padoin
Importance: Within cosmetic facial plastic surgery, there is considerable difficulty in producing high-quality scientific publications because of the lack of scientific tools that serve to transform sensations, such as more beautiful or rejuvenated, into numbers capable of being used in statistical analysis. Objective: To validate an objective evaluation method that can be used to define the perception of facial age in scientific studies. Design, Setting, and Participants: This is a cross-sectional, observational study of evaluation by plastic surgeons of 70 photographs of patients from a private care hospital performed from March 1, 2015, through April 30, 2016...
November 17, 2016: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/27891474/an-evaluation-of-use-of-botulinum-toxin-type-a-in-the-management-of-dynamic-forehead-wrinkles-a-clinical-study
#11
Avvaru Susmita, Naga Neelima Devi Kolli, Sridhar Meka, Srinivas Pandi Chakravarthi, Vivekanand Sabanna Kattimani, Krishna Prasad Lingamaneni, Latheef Saheb Shaik
INTRODUCTION: The pursuit of youth and beauty has undergone a resurgence of interest which is evidenced by increasing cosmetic procedures. Botulinum Toxin Type A (Botox) is one among the many procedures invented for facial rejuvenation which denervates certain muscles of facial expression responsible for facial wrinkles. It has been applied in the forehead, glabella, lateral canthal area and neck. In maxillofacial area hyperactive forehead wrinkles show sagging. AIM: This study was aimed to clinically evaluate the efficacy of Botox injection in the elimination of hyperdynamic forehead wrinkles and the objectives were to compare pre-operative and post-operative improvement in the number of wrinkles, photographic grading and patient satisfaction responses after 1(st) week, 4(th) week and 16(th) week...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27884907/books-a-body-of-work-an-anthology-of-poetry-and-medicine-a-body-beautiful
#12
Trevor Stammers
No abstract text is available yet for this article.
December 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27875610/the-beautiful-mess-of-clinical-research
#13
Christy J W Ledford
No abstract text is available yet for this article.
November 2016: Family Medicine
https://www.readbyqxmd.com/read/27872801/-beauty-contest-indicator-of-cognitive-ability-and-free-riding-strategies-results-from-a-scenario-experiment-about-pandemic-flu-immunization
#14
Björn Rönnerstrand
High immunization coverage rates are desirable in order to reduce total morbidity and mortality rates, but it may also provide an incentive for herd immunity free riding strategies. The aim of this paper was to investigate the link between cognitive ability and vaccination intention in a hypothetical scenario experiment about Avian Flu immunization. A between-subject scenario experiment was utilized to examine the willingness to undergo vaccination when the vaccination coverage was proclaimed to be 36, 62 and 88%...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27871344/hair-and-aging
#15
Graham A Turner, Ranjit K Bhogal
Hair is the ultimate personal beauty tool of self-expression. It is more malleable than skin and it is more personal than clothing; however, hair does not remain constant with age. Hair is arguably in peak condition at about 30 years of age. With time, there is a gradual change in many aspects of hair: hair diameter is reduced, hair density is decreased, androgenic alopecia may develop, and pigmentation may be diminished, producing a significant psychological impact. These age-related changes can be exacerbated by blast drying, heat straightening, perming, and coloring...
2016: Skinmed
https://www.readbyqxmd.com/read/27867350/berlyne-revisited-evidence-for-the-multifaceted-nature-of-hedonic-tone-in-the-appreciation-of-paintings-and-music
#16
Manuela M Marin, Allegra Lampatz, Michaela Wandl, Helmut Leder
In his seminal book on esthetics, Berlyne (1971) posited an inverted-U relationship between complexity and hedonic tone in arts appreciation, however, converging evidence for his theory is still missing. The disregard of the multidimensionality of complexity may explain some of the divergent results. Here, we argue that definitions of hedonic tone are manifold and systematically examined whether the nature of the relationship between complexity and hedonic tone is determined by the specific measure of hedonic tone...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27864759/histochemical-staining-of-%C3%AE-glucuronidase-and-its-spatial-quantification
#17
Chloé Béziat, Jürgen Kleine-Vehn, Elena Feraru
Microscope images of plant specimens showing expression of GUS markers, besides being very beautiful, provide useful information regarding various biological processes. However, the information extracted from these images is often purely qualitative, and in many publications is not subjected to quantification. Here, we describe a very simple quantification method for GUS histochemical staining that enables detection of subtle differences in gene expression at cellular, tissue, or organ level. The quantification method described is based on the freely available image analysis software ImageJ that is widely used by the scientific community...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27861008/island-life-is-calling-make-the-move-to-guernsey
#18
Erin Dean
The island of Guernsey has plenty to offer: beautiful countryside, miles of beaches and mild winters. But, like mainland UK, it finds recruiting nurses a challenge.
November 2, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27856034/understanding-local-community-s-values-worldviews-and-perceptions-in-the-galloway-and-southern-ayrshire-biosphere-reserve-scotland
#19
Maya I Hernes, Marc J Metzger
Biosphere reserves have been studied around the world, but methods to elicit community's values, worldviews and perceptions are missing. A greater understanding of these can help avoid tension and improve successful management. This paper used a mixed-methods survey to elicit local community's environmental values, ecological world views and perceptions of the Galloway and Southern Ayrshire Biosphere Reserve (GSABR). Over three weeks, forty participants from three communities of the GSABR responded to a semi-structured mixed-methods survey...
November 14, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27853683/medical-ethics-in-plastic-surgery-a-mini-review
#20
REVIEW
Nasrin Nejadsarvari, Ali Ebrahimi, Azin Ebrahimi, Haleh Hashem-Zade
Currently, cosmetic surgery is spread around the world. Several factors are involved in this rapidly evolving field such as socio-economic development, changes in cultural norms, globalization and the effects of Western culture, advertising, media, and mental disorders. Nowadays the cosmetic surgery is becoming a profitable business, which deals exclusively with human appearance and less from the perspective of beauty based on physical protests and considering factors such as sex, age, and race. The morality of plastic surgery subspecialty has undergone many moral dilemmas in the past few years...
September 2016: World Journal of Plastic Surgery
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