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https://www.readbyqxmd.com/read/28345263/nmr-solution-structure-of-the-red-subdomain-of-the-sleeping-beauty-transposase
#1
Tatiana A Konnova, Christopher M Singer, Irina V Nesmelova
DNA transposons can be employed for stable gene transfer in vertebrates. The Sleeping Beauty (SB) DNA transposon has been recently adapted for human application and is being evaluated in clinical trials, however its molecular mechanism is not clear. SB transposition is catalyzed by the transposase enzyme, which is a multi-domain protein containing the catalytic and the DNA-binding domains. The DNA-binding domain of SB transposase contains two structurally independent subdomains, PAI and RED. Recently, the structures of the catalytic domain and the PAI subdomain have been determined, however no structural information on the RED subdomain and its interactions with DNA has been available...
March 27, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28340646/essential-anatomy-and-evaluation-for-functional-rhinoplasty
#2
REVIEW
Justin C Sowder, Andrew J Thomas, Preston Daniel Ward
The nose, a prominent facial feature in defining facial beauty, is responsible for the fundamental physiologic functions of heating, humidifying, and filtering inspired air. When the normal balance of laminar and turbulent airflow become disturbed due to anatomic abnormalities, nasal obstruction may result. To successfully restore these basic physiologic functions, the surgeon must have a detailed understanding of the nasal anatomy and be able to successfully identify the specific cause of the nasal obstruction...
May 2017: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/28339167/if-you-know-you-will-also-see-population-pharmacokinetics-is-the-way-to-personalize-and-optimize-prophylaxis-in-hemophilia
#3
Erik Berntorp
The beauty of having a robust population PK model, as described here, for a specific factor concentrate is that the model is based on many PK curves (in this case n= 130) using rich sampling (in this case 9 samples taken after infusion up to 72 hours in patients aged ≥ 12 years, for some subjects even up to 96 hours). For patients below the age of 12, five samples were taken for practical reasons. If the model is robust then theoretically, This article is protected by copyright. All rights reserved.
March 24, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28335511/1st-workshop-of-the-canadian-society-for-virology
#4
Craig McCormick, Nathalie Grandvaux
The 1st Workshop of the Canadian Society for Virology (CSV2016) was a Special Workshop of the 35th Annual Meeting for the American Society for Virology, held on 18 June 2016 on the beautiful Virginia Tech campus in Blacksburg, Virginia. The workshop provided a forum for discussion of recent advances in the field, in an informal setting conducive to interaction with colleagues. CSV2016 featured two internationally-renowned Canadian keynote speakers who discussed translational virology research; American Society for Virology President Grant McFadden (then from University of Florida, now relocated to Arizona State University) who presented his studies of oncolytic poxviruses, while Matthew Miller (McMaster University) reviewed the prospects for a universal influenza vaccine...
March 20, 2017: Viruses
https://www.readbyqxmd.com/read/28332712/-for-beauty-is-nothing-but-the-barely-endurable-onset-of-terror-outline-of-a-general-psychoanalytic-aesthetics
#5
Sebastian Leikert
Even close to 80 years after Freud's words that psychoanalysis "has scarcely anything to say about beauty" (Freud, Civilization and its Discontents, SE 21, p. 82) the question of a specific psychoanalytic aesthetic is still faced with a deficit in theory. Since aesthetics is related to Aisthesis, the Greek word for 'perception', a psychoanalytic aesthetic can solely emerge from a psychoanalysis of perceptive structures. The term 'kinaesthetic semantic' is introduced in order to exemplify via music how perceptive experiences must be structured for them to be experienced as beautiful...
March 23, 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/28331752/body-image-of-women-with-breast-cancer-after-mastectomy-a-qualitative-research
#6
Sema Koçan, Ayla Gürsoy
OBJECTIVE: To gain a holistic and deep understanding about how mastectomy effects the body image of women who have breast cancer. MATERIALS AND METHODS: The sample of this qualitative descriptive study consisted of twenty patients who underwent mastectomy procedures. Semi-structured interviews were conducted during the second week after mastectomy. Each interview was transcribed verbatim, and a thematic analysis was performed. RESULTS: After the mastectomy, the findings related to the women's body image and their experiences were specified as four main themes and seven sub-themes...
October 2016: J Breast Health (2013)
https://www.readbyqxmd.com/read/28327250/an-assessment-of-the-mating-motive-explanation-of-the-beauty-premium-in-market-based-settings
#7
Enrichetta Ravina
Labor market and real-life studies were not designed to discriminate between evolutionary and taste-based and stereotype explanations for the beauty premium, have too many confounding effects, and lack crucial information. Smaller-stake and experimental studies provide more compelling evidence in favor of mating motives and suggest the direction of future research for the economists' field studies.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28327245/just-my-imagination-beauty-premium-and-the-evolved-mental-model
#8
Ryo Oda
Imagination, an important feature of the human mind, may be at the root of the beauty premium. The evolved human capacity for simulating the real world, developed as an adaptation to a complex social environment, may offer the key to understanding this and many other aspects of human behavior.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28327239/mating-motives-are-neither-necessary-nor-sufficient-to-create-the-beauty-premium
#9
Sebastian Hafenbrädl, Jason Dana
Mating motives lead decision makers to favor attractive people, but this favoritism is not sufficient to create a beauty premium in competitive settings. Further, economic approaches to discrimination, when correctly characterized, could neatly accommodate the experimental and field evidence of a beauty premium. Connecting labor economics and evolutionary psychology is laudable, but mating motives do not explain the beauty premium.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28327234/it-is-not-all-about-mating-attractiveness-predicts-partner-value-across-multiple-relationship-domains
#10
Adar B Eisenbruch, Aaron W Lukaszewski, James R Roney
An account of the "beauty premium" based only on mating motivations overlooks adaptationist models of social valuation that have broader explanatory power. We suggest a broader approach based on evolved preferences for attractive partners in multiple cooperative domains (not just mating), which accounts for many observations of attractiveness-based preferential treatment more comfortably than does the target article's mating-specific account.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28326611/mechanical-characterization-of-curly-hair-influence-of-the-use-of-nonconventional-hair-straightening-treatments
#11
M G A Leite, P M B G Maia Campos
BACKGROUND/PURPOSE: Hair straighteners are very popular around the world, although they can cause great damage to the hair. Thus, the characterization of the mechanical properties of curly hair using advanced techniques is very important to clarify how hair straighteners act on hair fibers and to contribute to the development of effective products. On this basis, we chose two nonconventional hair straighteners (formaldehyde and glyoxylic acid) to investigate how hair straightening treatments affect the mechanical properties of curly hair...
March 21, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28325400/the-blind-patient-and-the-cosmetic-dermatology-consultation-who-defines-beauty
#12
Sailesh Konda, Puja Kathrotiya, Jane M Grant-Kels
No abstract text is available yet for this article.
April 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28325297/engineering-of-pedf-expressing-primary-pigment-epithelial-cells-by-the-sb-transposon-system-delivered-by-pfar4-plasmids
#13
Gabriele Thumann, Nina Harmening, Cécile Prat-Souteyrand, Corinne Marie, Marie Pastor, Attila Sebe, Csaba Miskey, Laurence D Hurst, Sabine Diarra, Martina Kropp, Peter Walter, Daniel Scherman, Zoltán Ivics, Zsuzsanna Izsvák, Sandra Johnen
Neovascular age-related macular degeneration (nvAMD) is characterized by choroidal blood vessels growing into the subretinal space, leading to retinal pigment epithelial (RPE) cell degeneration and vision loss. Vessel growth results from an imbalance of pro-angiogenic (e.g., vascular endothelial growth factor [VEGF]) and anti-angiogenic factors (e.g., pigment epithelium-derived factor [PEDF]). Current treatment using intravitreal injections of anti-VEGF antibodies improves vision in about 30% of patients but may be accompanied by side effects and non-compliance...
March 17, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28324196/should-we-genetically-select-for-the-beauty-norm-of-fair-skin
#14
Herjeet Marway
Fair skin is often regarded as a beauty ideal in many parts of the world. Genetic selection for non-disease traits may allow reproducers to select fair skin for the purposes of beauty, and may be justified under various procreative principles. In this paper I assess the ethics of genetic selection for fair skin as a beauty feature. In particular, I explore the discriminatory aspects and demands of such selection. Using race and colour hierarchies that many would find objectionable, I argue that selection for beauty that is underpinned by such hierarchies is not a trivial selection...
March 21, 2017: Health Care Analysis: HCA: Journal of Health Philosophy and Policy
https://www.readbyqxmd.com/read/28321536/effect-of-sinapic-acid-on-hair-growth-promoting-in-human-hair-follicle-dermal-papilla-cells-via-akt-activation
#15
Hyunju Woo, Seungjun Lee, Seungbeom Kim, Deokhoon Park, Eunsun Jung
Hair loss known as alopecia is caused by abnormal hair follicle cycling including shortening of the anagen (growth) phase and changing of hair follicle morphology with miniaturization. In accordance with the life extension, the quality of life is considered to be a most important thing. The yearning for healthy and beautiful hair and low self esteem due to hair loss had negative influence on the quality of life with psychosocial maladjustment. The objective of this research was to identify new compound that can be used as a drug to promote hair growth...
March 20, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28319090/a-single-copy-sleeping-beauty-transposon-mutagenesis-screen-identifies-new-pten-cooperating-tumor-suppressor-genes
#16
Jorge de la Rosa, Julia Weber, Mathias Josef Friedrich, Yilong Li, Lena Rad, Hannes Ponstingl, Qi Liang, Sandra Bernaldo de Quirós, Imran Noorani, Emmanouil Metzakopian, Alexander Strong, Meng Amy Li, Aurora Astudillo, María Teresa Fernández-García, María Soledad Fernández-García, Gary J Hoffman, Rocío Fuente, George S Vassiliou, Roland Rad, Carlos López-Otín, Allan Bradley, Juan Cadiñanos
The overwhelming number of genetic alterations identified through cancer genome sequencing requires complementary approaches to interpret their significance and interactions. Here we developed a novel whole-body insertional mutagenesis screen in mice, which was designed for the discovery of Pten-cooperating tumor suppressors. Toward this aim, we coupled mobilization of a single-copy inactivating Sleeping Beauty transposon to Pten disruption within the same genome. The analysis of 278 transposition-induced prostate, breast and skin tumors detected tissue-specific and shared data sets of known and candidate genes involved in cancer...
March 20, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28318919/the-current-preferred-female-lip-ratio
#17
Paul I Heidekrueger, Sabrina Juran, Caroline Szpalski, Lorenz Larcher, Reuben Ng, P Niclas Broer
BACKGROUND: Perception of beauty is influenced by the individual's demographic background and characteristics. However, objective measurements and ratios remain the foundation for aesthetic evaluations. This study aimed to elucidate if there exists a universally applicable ideal upper to lower lip ratio. METHODS: An interactive online survey was designed. Modifiable ranges of lip ratios were achieved via digital alteration, enabling participants to change the ratio of a single female model's lips...
February 12, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28315810/trappings-of-femininity-a-test-of-the-beauty-as-currency-hypothesis-in-shaping-college-women-s-gender-activism
#18
Rachel M Calogero, Tracy L Tylka, Lois C Donnelly, Amber McGetrick, Andrea Medrano Leger
This study investigated whether believing beauty is a primary currency for women operates as an antecedent force in the relation between self-objectification and gender activism. Ninety-four ethnically diverse women attending a small liberal arts college in the southeastern United States completed the study questionnaires online for course credit. Preliminary results demonstrated beauty as currency belief, self-objectification, and support for the gender status quo were negatively associated with gender activism...
March 15, 2017: Body Image
https://www.readbyqxmd.com/read/28314174/key-developmental-transitions-during-flower-morphogenesis-and-their-regulation
#19
REVIEW
Doris Wagner
The arrangement of flowers on flowering stems called inflorescences contributes to the beauty of the natural world and enhances seed yield, impacting species survival and human sustenance. During the reproductive phase, annual/monocarpic plants like Arabidopsis and most crops form two types of lateral structures: indeterminate lateral inflorescences and determinate flowers. Their stereotypical arrangement on the primary inflorescence stem determines the species-specific inflorescence architecture. This architecture can be modulated in response to environmental cues to enhance reproductive success...
March 14, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28306728/uncovering-noisy-social-signals-using-optimization-methods-from-experimental-physics-to-study-social-phenomena
#20
Maurits Kaptein, Robin van Emden, Davide Iannuzzi
Due to the ubiquitous presence of treatment heterogeneity, measurement error, and contextual confounders, numerous social phenomena are hard to study. Precise control of treatment variables and possible confounders is often key to the success of studies in the social sciences, yet often proves out of the realm of control of the experimenter. To amend this situation we propose a novel approach coined "lock-in feedback" which is based on a method that is routinely used in high-precision physics experiments to extract small signals out of a noisy environment...
2017: PloS One
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