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https://www.readbyqxmd.com/read/28723563/a-positive-feedback-loop-between-sestrin2-and-mtorc2-is-required-for-the-survival-of-glutamine-depleted-lung-cancer-cells
#1
Jun-Kyu Byun, Yeon-Kyung Choi, Ji-Hyun Kim, Ji Yun Jeong, Hui-Jeon Jeon, Mi-Kyung Kim, Ilseon Hwang, Shin-Yup Lee, You Mie Lee, In-Kyu Lee, Keun-Gyu Park
Proper regulation of mTORC1 and mTORC2 upon nutrient starvation is critical for cancer cell survival. Upregulation of Sestrin2 in response to glutamine deprivation rescues cell death by suppressing mTORC1. However, the contribution of mTORC2 to Sestrin2-mediated mTORC1 suppression remains unclear. Here, we report that both Sestrin2 and mTORC2 are upregulated in glutamine-depleted lung cancer cells. Moreover, glutamine depletion caused Sestrin2 to associate with mTORC2, which was required for the increase in Sestrin2 protein stability and the reduction in mTORC1 activity...
July 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28720771/plasmonically-enhanced-reflectance-of-heat-radiation-from-low-bandgap-semiconductor-microinclusions
#2
Janika Tang, Vaibhav Thakore, Tapio Ala-Nissila
Increased reflectance from the inclusion of highly scattering particles at low volume fractions in an insulating dielectric offers a promising way to reduce radiative thermal losses at high temperatures. Here, we investigate plasmonic resonance driven enhanced scattering from microinclusions of low-bandgap semiconductors (InP, Si, Ge, PbS, InAs and Te) in an insulating composite to tailor its infrared reflectance for minimizing thermal losses from radiative transfer. To this end, we compute the spectral properties of the microcomposites using Monte Carlo modeling and compare them with results from Fresnel equations...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28719741/macroscopic-strain-induced-transition-from-quasi-infinite-gold-nanoparticle-chains-to-defined-plasmonic-oligomers
#3
Anja Maria Steiner, Martin Mayer, Maximilian Seuss, Svetoslav Nikolov, Kenneth D Harris, Alexander Alexeev, Christian Kuttner, Tobias A F Koenig, Andreas Fery
We investigate the formation of chains of few plasmonic nanoparticles - so called plasmonic oligomers - by strain induced fragmentation of linear particle assemblies. Detailed investigations of the fragmentation process are conducted by in-situ atomic force microscopy (AFM) and UV-vis-NIR spectroscopy. Based on these experimental results and mechanical simulations computed by the lattice spring model (LSM), we propose a formation mechanism which explains the observed decrease of chain polydispersity upon increasing strain and provides experimental guidelines for tailoring chain length distribution...
July 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28713783/streptococcus-pyogenes-phospholipase-a2-induces-the-expression-of-adhesion-molecules-on-human-umbilical-vein-endothelial-cells-and-aorta-of-mice
#4
Masataka Oda, Hisanori Domon, Mie Kurosawa, Toshihito Isono, Tomoki Maekawa, Masaya Yamaguchi, Shigetada Kawabata, Yutaka Terao
The Streptococcus pyogenes phospholipase A2 (SlaA) gene is highly conserved in the M3 serotype of group A S. pyogenes, which often involves hypervirulent clones. However, the role of SlaA in S. pyogenes pathogenesis is unclear. Herein, we report that SlaA induces the expression of intercellular adhesion molecule 1 (ICAM1) and vascular cell adhesion molecule 1 (VCAM1) via the arachidonic acid signaling cascade. Notably, recombinant SlaA induced ICAM1 and VCAM1 expression in human umbilical vein endothelial cells (HUVECs), resulting in enhanced adhesion of human monocytic leukemia (THP-1) cells...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28690314/evolution-of-npm1-negative-therapy-related-myelodysplastic-syndromes-following-curative-treatment-of-npm1-mutant-aml
#5
S Herold, K Sockel, C Sayehli, R Herbst, U Dührsen, U Oelschlägel, A Böttner, H Hindahl, J Kullmer, S Helas, M Sauer, B Mohr, A Mies, M Bornhäuser, G Ehninger, C Röllig, C Thiede, U Platzbecker
Leukemia accepted article preview online, 10 July 2017. doi:10.1038/leu.2017.217.
July 10, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28684745/mie-scatter-spectra-based-device-for-instant-contact-free-and-specific-diagnosis-of-bacterial-skin-infection
#6
Robin E Sweeney, Elizabeth Budiman, Jeong-Yeol Yoon
Rapid and specific diagnostic techniques are needed to expedite specific treatment of bacterial skin infections with narrow-spectrum antibiotics, rather than broad-spectrum. Through this work a device was developed to determine the presence of and species responsible for a bacterial skin infection using differences in Mie scatter spectra created by different bacterial species. A 650 nm LED at five different incident angles is used to illuminate the tissue, with Mie scatter being detected by PIN photodiodes at eight different detection angles...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28684638/high-intensity-interval-exercise-and-glycemic-control-in-adolescents-with-type-one-diabetes-mellitus-a-case-study
#7
Emma J Cockcroft, Christopher Moudiotis, Julie Kitchen, Bert Bond, Craig A Williams, Alan R Barker
Current physical activity guidelines for youth with type 1 diabetes (T1D) are poorly supported by empirical evidence and the optimal dose of physical activity to improve glycemic control is unknown. This case report documents the effect of acute high-intensity interval exercise (HIIE) and moderate-intensity exercise (MIE) on 24-h glycemic control in three adolescents with T1D using continuous glucose monitoring. Results highlight varied individual response to exercise across the participants. In two participants both MIE and HIIE resulted in a drop in blood glucose during exercise (-38 to -42% for MIE and -21-46% in HIIE) and in one participant both MIE and HIIE resulted in increased blood glucose (+19% and + 36%, respectively)...
July 2017: Physiological Reports
https://www.readbyqxmd.com/read/28680060/novel-oestrogen-receptor-%C3%AE-selective-ligand-reduces-obesity-and-depressive-like-behaviour-in-ovariectomized-mice
#8
Daimei Sasayama, Nobuhiro Sugiyama, Shigeru Yonekubo, Akiko Pawlak, Hiroyasu Murasawa, Mie Nakamura, Morimichi Hayashi, Takashi Ogawa, Makoto Moro, Shinsuke Washizuka, Naoji Amano, Kazuhiro Hongo, Hideki Ohnota
Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity and depressive symptoms. To delineate potential effects of ERβ activation in postmenopausal women, we investigated the effects of a novel oestrogen receptor β-selective ligand (C-1) in ovariectomized mice...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28677920/the-genetic-heterogeneity-among-different-mouse-strains-impacts-the-lung-injury-potential-of-multiwalled-carbon-nanotubes
#9
Xiang Wang, Yu-Pei Liao, Donatello Telesca, Chong Hyun Chang, Tian Xia, André E Nel
Genetic variation constitutes an important variable impacting the susceptibility to inhalable toxic substances and air pollutants, as reflected by epidemiological studies in humans and differences among animal strains. While multiwalled carbon nanotubes (MWCNTs) are capable of causing lung fibrosis in rodents, it is unclear to what extent the genetic variation in different mouse strains influence the outcome. Four inbred mouse strains, including C57Bl/6, Balb/c, NOD/ShiLtJ, and A/J, to test the pro-fibrogenic effects of a library of MWCNTs in vitro and in vivo are chosen...
July 5, 2017: Small
https://www.readbyqxmd.com/read/28676724/a-mie-resonant-antenna-with-high-sensitivity-for-force-and-strain-measurement
#10
Lingling Wu, Xiaoqing Xi, Bo Li, Ji Zhou
We demonstrate the experimental and simulated performances of a Mie resonant antenna for force sensing with high sensitivity for compressive force and strain measurements inside soft materials. The proposed sensor is compatible with biological specimens and has small dimensions. It comprises a pair of dielectric cubes and an elastic layer of silicone rubber. The applied force is determined by measuring the redshift of the operating frequency when a mechanical load applied. Both simulated and experimental results demonstrate that the relationship between the frequency shift of the sensor and the applied compressive load could be fitted well using a quadratic equation with a maximum fitting error less than 17%, which enables highly sensitive telemetric force measurements to be performed inside structures by observing the operating frequency shift...
July 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28675143/diatom-frustules-decorated-with-zinc-oxide-nanoparticles-for-enhanced-optical-properties
#11
Francesca Romana Lamastra, Maria Luisa Grilli, Grigore Leahu, A Belardini, Roberto Li Voti, Concita Sibilia, Damiano Salvatori, Ilaria Cacciotti, Francesca Nanni
Zinc oxide nanoparticles (ZnO) were synthesized on diatomite (DE) surface by a low temperature sol gel technique, starting from zinc acetate dihydrate (Zn(CH<sub>3</sub>COO)<sub>2</sub> • 2H<sub>2</sub>O ) solution in water/ethyl alcohol, in presence of triethanolamine (TEA) with functions of Zn<sup>2+</sup> chelating agent, catalyst and mediator of nanoparticle growth on DE surface. Microstructural features were investigated by field emission scanning electron microscopy and X-ray diffraction...
July 4, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28674519/somatostatin-ires-cre-mice-between-knockout-and-wild-type
#12
Cécile Viollet, Axelle Simon, Virginie Tolle, Alexandra Labarthe, Dominique Grouselle, Yann Loe-Mie, Michel Simonneau, Guillaume Martel, Jacques Epelbaum
The neuropeptide somatostatin (SOM) is widely expressed in rodent brain and somatostatin-IRES-Cre (SOM-cre) mouse strains are increasingly used to unravel the physiology of SOM-containing neurons. However, while knock-in targeting strategy greatly improves Cre-Lox system accuracy, recent reports have shown that genomic insertion of Cre construct per se can markedly affect physiological function. We show that Cre transgene insertion into the 3'UTR of the somatostatin gene leads to the selective and massive depletion of endogenous SOM in all tested brain regions...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28667683/pouch-failures-following-ileal-pouch-anal-anastomosis-for-ulcerative-colitis
#13
Anders Mark-Christensen, Rune Erichsen, Søren Brandsborg, Frederik Rønne Pachler, Charlotte Buchard Nørager, Niels Johansen, Jørn Helmut Pachler, Ole Thorlacius-Ussing, Mie Dilling Kjaer, Niels Qvist, Louise Preisler, Jens Hillingsø, Jacob Rosenberg, Søren Laurberg
BACKGROUND: The ileal pouch-anal anastomosis is a procedure offered to patients with ulcerative colitis who opt for restoration of bowel continuity. The aim of this study was to determine the risk of pouch failure and ascertain risk factors associated with failure. METHOD: 1,991 patients with ulcerative colitis operated with ileal pouch-anal anastomosis in Denmark in the period 1980-2013 were included. Pouch failure was defined as excision of the pouch or presence of a stoma un-reversed within one year after its creation...
July 1, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28665785/informatics-for-health-2017-advancing-both-science-and-practice
#14
Philip J Scott, Ronald Cornet, Colin McCowan, Niels Peek, Paolo Fraccaro, Nophar Geifman, Wouter T Gude, William Hulme, Glen P Martin, Richard Williams
INTRODUCTION: The Informatics for Health congress, 24-26 April 2017, in Manchester, UK, brought together the Medical Informatics Europe (MIE) conference and the Farr Institute International Conference. This special issue of the Journal of Innovation in Health Informatics contains 113 presentation abstracts and 149 poster abstracts from the congress. DISCUSSION: The twin programmes of "Big Data" and "Digital Health" are not always joined up by coherent policy and investment priorities...
April 21, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28664508/correlation-between-expression-of-recombinant-proteins-and-abundance-of-h3k4me3-on-the-enhancer-of-human-cytomegalovirus-major-immediate-early-promoter
#15
Benjamin P C Soo, Julian Tay, Shirelle Ng, Steven C L Ho, Yuansheng Yang, Sheng-Hao Chao
Role of epigenetic regulation in the control of gene expression is well established. The impact of several epigenetic mechanisms, such as DNA methylation and histone acetylation, on recombinant protein production in mammalian cells has been investigated recently. Here we investigate the correlation between the selected epigenetic markers and five trastuzumab biosimilar-producing Chinese hamster ovary (CHO) cell lines in which the expression of trastuzumab is driven by human cytomegalovirus (HCMV) major immediate-early (MIE) promoter...
August 2017: Molecular Biotechnology
https://www.readbyqxmd.com/read/28663871/validation-of-a-spectral-light-scattering-method-to-differentiate-large-from-small-particles-in-intraocular-lenses
#16
Grzegorz Łabuz, Eleni Papadatou, Fernando Vargas-Martín, Norberto López-Gil, Nicolaas J Reus, Thomas J T P van den Berg
A psychophysical approach has been designed to measure straylight from intraocular lenses (IOLs) in vitro. This approach uses a clinical straylight meter (C-Quant) and an observer's eye as optical detector. Based on this, we introduced a method for study of straylight-wavelength dependency for IOLs. This dependency can be used to distinguish between 2 types of scattering particles (small and large) as defined by Mie theory. Validation was performed using a turbidity standard and scattering filters. Several IOLs were analyzed to identify potential scattering sources...
March 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28663852/correlation-of-the-derivative-as-a-robust-estimator-of-scatterer-size-in-optical-coherence-tomography-oct
#17
M Kassinopoulos, E Bousi, I Zouvani, C Pitris
The size-dependent spectral variations, predicted by Mie theory, have already been considered as a contrast enhancement mechanism in optical coherence tomography. In this work, a new spectroscopic metric, the bandwidth of the correlation of the derivative, was developed for estimating scatterer size which is more robust and accurate compared to existing methods. Its feasibility was demonstrated using phantoms containing polystyrene microspheres as well as images of normal and cancerous human colon. The results are very promising, suggesting that the proposed metric could be utilized for measuring nuclear size distribution, a diagnostically valuable marker, in human tissues...
March 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28662104/vibrio-aphrogenes-sp-nov-in-the-rumoiensis-clade-isolated-from-a-seaweed
#18
Mami Tanaka, Shoko Endo, Fumihito Kotake, Nurhidayu Al-Saari, A K M Rohul Amin, Gao Feng, Sayaka Mino, Hidetaka Doi, Yoshitoshi Ogura, Tetsuya Hayashi, Wataru Suda, Masahira Hattori, Isao Yumoto, Toko Sawabe, Tomoo Sawabe, Toshiyoshi Araki
A novel strain Vibrio aphrogenes sp. nov. strain CA-1004T isolated from the surface of seaweed collected on the coast of Mie Prefecture in 1994 [1] was characterized using polyphasic taxonomy including multilocus sequence analysis (MLSA) and a genome based comparison. Both phylogenetic analyses on the basis of 16S rRNA gene sequences and MLSA based on eight protein-coding genes (gapA, gyrB, ftsZ, mreB, pyrH, recA, rpoA, and topA) showed the strain could be placed in the Rumoiensis clade in the genus Vibrio...
2017: PloS One
https://www.readbyqxmd.com/read/28660148/evaluation-of-biomarkers-in-egyptian-patients-with-different-grades-of-nonalcoholic-fatty-liver-disease
#19
Ibrahim H Borai, Yehia Shaker, Maha Moustafa Kamal, Wafaa M Ezzat, Esmat Ashour, Mie Afify, Weaam Gouda, Maha M Elbrashy
Background and Aims: Nonalcoholic fatty liver disease (NAFLD) is a silent disease; its spectrum includes simple steatosis, nonalcoholic steatohepatitis and fibrosis. Pro- and anti-inflammatory cytokines play roles in the pathogenesis of NAFLD and insulin resistance (IR). Moreover, plasma cell antigen-1 (PC-1) is related to IR and associated with NAFLD progression. Therefore, we aimed to detect biomarkers, ultrasonographic and anthropometric findings capable of differentiating NAFLD grades, since most previous investigators were concerned more with NAFLD patients without classifying them into grades...
June 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28659128/cmisg1701-a-multicenter-prospective-randomized-phase-iii-clinical-trial-comparing-neoadjuvant-chemoradiotherapy-to-neoadjuvant-chemotherapy-followed-by-minimally-invasive-esophagectomy-in-patients-with-locally-advanced-resectable-esophageal-squamous-cell-carcinoma
#20
Han Tang, Lijie Tan, Yaxing Shen, Hao Wang, Miao Lin, Mingxiang Feng, Songtao Xu, Weigang Guo, Cheng Qian, Tianshu Liu, Zhaochong Zeng, Yingyong Hou, Zhentao Yu, Hongjing Jiang, Zhigang Li, Chun Chen, Changhong Lian, Ming Du, Hecheng Li, Deyao Xie, Jun Yin, Naiqing Zhao, Qun Wang
BACKGROUND: Neoadjuvant chemoradiation is not recommended as an approach for treatment of esophageal squamous cell carcinoma due to its significant postoperative mortality. However, it is assumed the combination of neoadjuvant chemoradiation with minimally invasive esophagectomy (MIE) may reduce postoperative mortality, which can revive preoperative chemoradiation. No randomized controlled studies comparing neoadjuvant chemoradiation plus MIE with neoadjuvant chemotherapy plus MIE have been performed so far...
June 28, 2017: BMC Cancer
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