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https://www.readbyqxmd.com/read/29348562/non-marine-palaeoenvironment-associated-to-the-earliest-tetrapod-tracks
#1
Martin Qvarnström, Piotr Szrek, Per E Ahlberg, Grzegorz Niedźwiedzki
Opinions differ on whether the evolution of tetrapods (limbed vertebrates) from lobe-finned fishes was directly linked to terrestrialization. The earliest known tetrapod fossils, from the Middle Devonian (approximately 390 million years old) of Zachełmie Quarry in Poland, are trackways made by limbs with digits; they document a direct environmental association and thus have the potential to help answer this question. However, the tetrapod identity of the tracks has recently been challenged, despite their well-preserved morphology, on account of their great age and supposedly shallow marine (intertidal or lagoonal) depositional environment...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348405/directional-sound-beam-emission-from-a-configurable-compact-multi-source-system
#2
Jiajun Zhao, Rasha Al Jadhali, Likun Zhang, Ying Wu
We propose to achieve efficient emission of highly directional sound beams from multiple monopole sources embedded in a subwavelength enclosure. Without the enclosure, the emitted sound fields have an indistinguishable or omnidirectional radiation directivity in far fields. The strong directivity formed in the presence of the enclosure is attributed to interference of sources under degenerate Mie resonances in the enclosure of anisotropic property. Our numerical simulations of sound emission from the sources demonstrate the radiation of a highly directed sound beam of unidirectional or bidirectional patterns, depending on how the sources are configured inside the enclosure...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343581/the-5-untranslated-region-of-the-major-immediate-early-mrna-is-necessary-for-efficient-human-cytomegalovirus-replication
#3
Kyle C Arend, Erik M Lenarcic, Nathaniel J Moorman
The human cytomegalovirus (HCMV) IE1 and IE2 proteins are critical regulators of virus replication. Both proteins are needed to efficiently establish lytic infection, and nascent expression of IE1 and IE2 is critical for reactivation from latency. The regulation of IE1 and IE2 protein expression is thus a central event in the outcome of HCMV infection. Transcription of the primary transcript encoding both IE1 and IE2 is well studied, but relatively little is known about the post-transcriptional mechanisms that control IE1 and IE2 protein synthesis...
January 17, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29342878/improved-photo-ignition-of-carbon-nanotubes-ferrocene-using-a-lipophilic-porphyrin-under-white-power-led-irradiation
#4
Paolo Visconti, Patrizio Primiceri, Roberto de Fazio, Antonio Paolo Carlucci, Selma Elaine Mazzetto, Giuseppe Mele
The aim of this work is to investigate and characterize the photo-ignition process of dry multi-walled carbon nanotubes (MWCNTs) mixed with ferrocene (FeCp₂) powder, using an LED (light-emitting diode) as the light source, a combination that has never been used, to the best of our knowledge. The ignition process was improved by adding a lipophilic porphyrin (H₂Pp) in powder to the MWCNTs/FeCp₂ mixtures-thus, a lower ignition threshold was obtained. The ignition tests were carried out by employing a continuous emission and a pulsed white LED in two test campaigns...
January 13, 2018: Materials
https://www.readbyqxmd.com/read/29334721/efficacy-and-safety-of-tocilizumab-in-korean-patients-with-active-rheumatoid-arthritis
#5
Han Joo Baek, Mie Jin Lim, Won Park, Sung Hwan Park, Seung-Cheol Shim, Dae-Hyun Yoo, Hyun Ah Kim, Soo Kon Lee, Yun Jong Lee, Young Eun Park, Hoon-Suk Cha, Yeong-Wook Song
Background/Aims: To investigate the efficacy and safety of tocilizumab (TCZ) humanized anti-interleukin-6 receptor monoclonal antibody, in Korean patients with active rheumatoid arthritis (RA) refractory to conventional disease modifying anti-rheumatic drugs (DMARDs) including methotrexate (MTX). Methods: The main study was a 24-week, randomized, double-blind, controlled trial that was followed by a 48-week, open-labeled, extension phase. TCZ (8 mg/kg) or placebo was intravenously administered every 4 weeks...
January 17, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29332925/pulmonary-artery-pseudoaneurysm-secondary-to-lung-inf-lammation
#6
Shinichirou Ishimoto, Hiroyuki Sakurai, Ryouta Higure, Riken Kawachi, Mie Shimamura
Pulmonary artery aneurysms (PAA) and pseudoaneurysms (PAP) are caused by infections, vasculitis, trauma, pulmonary hypertension, congenital heart disease, and connective tissue disease. Most cases of such aneurysm occur in the trunk or major branches of the pulmonary artery, while the peripheral type is less common. The treatment modalities are medical therapy, surgery, and percutaneous catheter embolization. The mortality rate associated with rupture is approximately 50%. We encountered a case of a 53-year-old man with a pulmonary artery pseudoaneurysm secondary to pneumonia and cavity formation during chemotherapy for acute myeloid leukemia (AML)...
January 15, 2018: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29332373/use-of-adverse-outcome-pathways-aop-in-chemical-management-potential-advantages-and-limitations
#7
Jaeseong Jeong, Jinhee Choi
Amid revolutionary changes in toxicity assessment brought about by increasing regulation of chemicals, adverse outcome pathways (AOPs) have emerged as a useful framework to assess adverse effect of chemicals using molecular level effect, which aid in setting environmental regulation policies. AOPs are biological maps that describe mechanisms linking molecular initiating event to adverse outcomes at an individual level. Each AOP consists of a Molecular Initiating Event (MIE), Key Events (KEs), and an Adverse Outcome (AO)...
December 30, 2017: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/29332350/short-and-long-term-outcomes-of-minimally-invasive-esophagectomy-in-elderly-patients-with-esophageal-squamous-cell-carcinoma
#8
H Zhao, Gang Liu, S Wei, H Liu
PURPOSE: In recent years, there has been an increase in the number of elderly patients undergoing surgery for esophageal squamous cell carcinoma (ESCC). However, there are few studies on short- and long-term outcomes of minimally invasive esophagectomy (MIE) in such patients. The purpose of this study was to report both short- and long-term outcomes of MIE in elderly patients with ESCC. METHODS: A total of 273 patients with ESCC underwent MIE at our hospital from January 2010 to December 2016...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29328184/extinction-spectra-of-suspensions-of-microspheres-determination-of-the-spectral-refractive-index-and-particle-size-distribution-with-nanometer-accuracy
#9
Jonas Gienger, Markus Bär, Jörg Neukammer
A method is presented to infer simultaneously the wavelength-dependent real refractive index (RI) of the material of microspheres and their size distribution from extinction measurements of particle suspensions. To derive the averaged spectral optical extinction cross section of the microspheres from such ensemble measurements, we determined the particle concentration by flow cytometry to an accuracy of typically 2% and adjusted the particle concentration to ensure that perturbations due to multiple scattering are negligible...
January 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29319236/neoadjuvant-chemotherapy-followed-by-minimally-invasive-esophagectomy-is-safe-and-feasible-for-treatment-of-esophageal-squamous-cell-carcinoma
#10
Shaohua Ma, Tiansheng Yan, Dandan Liu, Keyi Wang, Jingdi Wang, Jintao Song, Tong Wang, Wei He, Jie Bai, Liang Jin, Xiaoxin Chen
BACKGROUND: The advantage of neoadjuvant chemotherapy (NAC) followed by open esophagectomy for treatment of esophageal squamous cell carcinoma has been widely recognized. However, the safety and feasibility of NAC for patients receiving minimally invasive esophagectomy (MIE) remain controversial. The purpose of this study was to evaluate the potential impact of prior neoadjuvant chemotherapy on the clinical outcome of MIE by comparing two groups of patients, MIE alone and NAC plus MIE...
January 10, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29302639/minimally-invasive-esophagectomy-via-sweet-approach-in-combination-with-cervical-mediastinoscopy-for-esophageal-squamous-cell-carcinoma-a-case-series
#11
Wenxiang Wang, Baihua Zhang, Xu Li, Jie Wu, Zhining Wu, Yan Ding, Desong Yang, Jinming Tang, Min Su, Junliang Ma, Xianman You, Jianping Liang, Yong Zhou
Objective: Minimally invasive esophagectomy (MIE) is increasingly used for the treatment of esophageal cancer. However, MIE via the Sweet approach has seldom been reported owing to the challenging procedure for a mediastinal lymph node. Thus, the approach of MIE via left-sided thoracoscopy coupled with video-assisted cervical mediastinoscopy (MIE-SM) was explored for eradicating the mediastinal lymph nodes and recurrent laryngeal nerve; the incidence of perioperative complications, mortality, and surgical radicality were analyzed...
December 2017: International Journal of Surgery. Oncology
https://www.readbyqxmd.com/read/29300816/phylogeographic-analysis-of-the-east-asian-goldenrod-solidago-virgaurea-complex-asteraceae-reveals-hidden-ecological-diversification-with-recurrent-formation-of-ecotypes
#12
Shota Sakaguchi, Takuma Kimura, Ryuta Kyan, Masayuki Maki, Takako Nishino, Naoko Ishikawa, Atsushi J Nagano, Mie N Honjo, Masaki Yasugi, Hiroshi Kudoh, Pan Li, Hyeok Jae Choi, Olga A Chernyagina, Motomi Ito
Background and Aims: The processes and mechanisms underlying lineage diversification are major topics in evolutionary biology. Eurasian goldenrod species of the Solidago virgaurea complex show remarkable morphological and ecological diversity in the Japanese Archipelago, with ecotypic taxa well adapted to specific environments (climate, edaphic conditions and disturbance regimes). The species complex is a suitable model to investigate the evolutionary processes of actively speciating plant groups, due to its ability to evolve in relation to environmental adaptation and its historical population dynamics...
December 29, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29298829/cellularity-of-thymic-epithelial-cells-in-the-postnatal-mouse
#13
Mie Sakata, Izumi Ohigashi, Yousuke Takahama
The molecular and cellular biology of thymic epithelial cells (TECs) often relies on the analysis of TECs isolated in enzymatically digested single-cell suspensions derived from mouse thymus. Many independent studies have reported that the estimated cellularity of total TECs isolated from one adult mouse is on the order of up to 105 However, these numbers appear extremely small given that the cellularity of total thymocytes exceeds 108 and that TECs play multiple roles in thymocyte development and repertoire formation...
January 3, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29297829/occurrence-of-pasteurellaceae-bacteria-in-the-oral-cavity-of-selected-marsupial-species
#14
Mie Johanne Hansen, Mads F Bertelsen, Androo Kelly, Anders Miki Bojesen
Eighty-two Pasteurellaceae isolates from marsupials characterized by phylogenetic analysis of rpoB gene sequences formed five distinct groups. Twenty-one strains from long-nosed potoroos ( Potorous tridactylus apicalis), spotted-tailed quolls ( Dasyurus maculatus), and eastern quolls ( Dasyurus viverrinus) made up group 1, which classified with Frederiksenia canicola. Group 2, 15 strains from Tasmanian devils ( Sarcophilus harrisii), common wombats ( Vombatus ursinus), common ring-tailed possums ( Pseudocheirus peregrinus), and eastern quolls, grouped with Pasteurella multocida...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29296005/physcomitrella-mads-box-genes-regulate-water-supply-and-sperm-movement-for-fertilization
#15
Shizuka Koshimizu, Rumiko Kofuji, Yuko Sasaki-Sekimoto, Masahide Kikkawa, Mie Shimojima, Hiroyuki Ohta, Shuji Shigenobu, Yukiko Kabeya, Yuji Hiwatashi, Yosuke Tamada, Takashi Murata, Mitsuyasu Hasebe
MIKC classic (MIKCC)-type MADS-box genes encode transcription factors that function in various developmental processes, including angiosperm floral organ identity. Phylogenetic analyses of the MIKCC-type MADS-box family, including genes from non-flowering plants, suggest that the increased numbers of these genes in flowering plants is related to their functional divergence; however, their precise functions in non-flowering plants and their evolution throughout land plant diversification are unknown. Here, we show that MIKCC-type MADS-box genes in the moss Physcomitrella patens function in two ways to enable fertilization...
January 3, 2018: Nature Plants
https://www.readbyqxmd.com/read/29286713/high-q-supercavity-modes-in-subwavelength-dielectric-resonators
#16
Mikhail V Rybin, Kirill L Koshelev, Zarina F Sadrieva, Kirill B Samusev, Andrey A Bogdanov, Mikhail F Limonov, Yuri S Kivshar
Recent progress in nanoscale optical physics is associated with the development of a new branch of nanophotonics exploring strong Mie resonances in dielectric nanoparticles with a high refractive index. The high-index resonant dielectric nanostructures form building blocks for novel photonic metadevices with low losses and advanced functionalities. However, unlike extensively studied cavities in photonic crystals, such dielectric resonators demonstrate low quality factors (Q factors). Here, we uncover a novel mechanism for achieving giant Q factors of subwavelength nanoscale resonators by realizing the regime of bound states in the continuum...
December 15, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29286190/impact-of-alcohol-dehydrogenase-aldehyde-dehydrogenase-polymorphism-on-clinical-outcome-in-patients-with-hypopharyngeal-cancer
#17
Mehmet Ozgur Avinçsal, Hirotaka Shinomiya, Masanori Teshima, Mie Kubo, Naoki Otsuki, Naomi Kyota, Ryohei Sasaki, Yoh Zen, Ken-Ichi Nibu
BACKGROUND: The purpose of this research was to investigate the association between alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) polymorphisms and hypopharyngeal squamous cell carcinoma (SCC) survival. METHODS: We genotyped ADH1B (rs1229984) and ALDH2 (rs671) single nucleotide polymorphisms (SNPs) in 85 Japanese male patients with hypopharyngeal SCC. The independent prognostic values of ADH1B-ALDH2 genotypes were analyzed by univariate and multivariate proportional hazard Cox regression, taking well-known clinical risk factors into account...
December 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/29284923/a-prerequisite-for-patient-centred-care-is-empowering-and-engaging-patients-in-the-digital-health-report-from-efmi-special-topic-conference-stc-2017
#18
Simon de Lusignan
The European Federation for Medical Informatics (EFMI) held its Special Topic Conference (STC) in October 2017 in Israel. EFMI holds STC's to focus on a particular issue, whereas its major annual conference Medical Informatics Europe (MIE) has a much wider remit. This conference challenged the informatics community to engage patients in digital health. Examples of the gap in digital engagementfrom the conference contributions include: An app to connect parents to a paediatric emergency department was presented...
December 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/29284122/application-of-elastin-based-nanoparticles-displaying-antibody-binding-domains-for-a-homogeneous-immunoassay
#19
Tsutomu Sugihara, Masayasu Mie, Eiry Kobatake
Nanoparticles are small size-controlled particles from 1 to 100 nm diameters and characterized by their structure, base material and functional units displayed on their surfaces. In this study, protein-based nanoparticles composed of a hydrophobic elastin-like peptide unit, a hydrophilic aspartic acid-rich peptide unit and displaying antibody binding domains on their surfaces, were designed and genetically synthesized. The constituent fusion proteins, termed ELP-D-C, were found to exist in monomeric form (ELP-D-C/monomer) at low temperature...
December 25, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29283382/thiopurine-drugs-repositioned-as-tyrosinase-inhibitors
#20
Joonhyeok Choi, You-Mie Lee, Jun-Goo Jee
Drug repositioning is the application of the existing drugs to new uses and has the potential to reduce the time and cost required for the typical drug discovery process. In this study, we repositioned thiopurine drugs used for the treatment of acute leukaemia as new tyrosinase inhibitors. Tyrosinase catalyses two successive oxidations in melanin biosynthesis: the conversions of tyrosine to dihydroxyphenylalanine (DOPA) and DOPA to dopaquinone. Continuous efforts are underway to discover small molecule inhibitors of tyrosinase for therapeutic and cosmetic purposes...
December 28, 2017: International Journal of Molecular Sciences
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