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Xiao-Feng Xiong, Hang Zhang, Christina R Underwood, Kasper Harpsøe, Thomas J Gardella, Mie F Wöldike, Michael Mannstadt, David E Gloriam, Hans Bräuner-Osborne, Kristian Strømgaard
G proteins are key mediators of G protein-coupled receptor signalling, which facilitates a plethora of important physiological processes. The cyclic depsipeptides YM-254890 and FR900359 are the only known specific inhibitors of the Gq subfamily of G proteins; however, no synthetic route has been reported previously for these complex natural products and they are not easily isolated from natural sources. Here we report the first total synthesis of YM-254890 and FR900359, as well as of two known analogues, YM-385780 and YM-385781...
November 2016: Nature Chemistry
Shin Yup Lee, Cheng Cheng Jin, Jin Eun Choi, Mi Jeong Hong, Deuk Kju Jung, Sook Kyung Do, Sun Ah Baek, Hyo Jung Kang, Hyo-Gyoung Kang, Sun Ha Choi, Won Kee Lee, Yangki Seok, Eung Bae Lee, Ji Yun Jeong, Kyung Min Shin, Sukki Cho, Seung Soo Yoo, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, You Mie Lee, In-Kyu Lee, Sanghoon Jheon, Jae Yong Park
This study was conducted to investigate whether polymorphisms of genes involved in glycolysis are associated with the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Forty-four single nucleotide polymorphisms (SNPs) of 17 genes in glycolytic pathway were investigated in a total of 782 patients with NSCLC who underwent curative surgical resection. The association of the SNPs with overall survival (OS) and disease free survival (DFS) were analyzed. Among the 44 SNPs investigated, four SNPs (ENO1 rs2274971A > G, PFKM rs11168417C > T, PFKP rs1132173C > T, PDK2 rs3785921G > A) were significantly associated with survival outcomes in multivariate analyses...
October 21, 2016: Scientific Reports
Rebeca Rodrigues Pessoa, Sarah Cueva Cândido Soares de Araújo, Selma Mie Isotani, Rosana Fiorini Puccini, Jacy Perissinoto
Purpose: To assess the development of language regarding the ability to recognize and interpret lexical ambiguity in low-birth-weight schoolchildren enrolled at the school system in the municipality of Embu das Artes, Sao Paulo state, compared with that of schoolchildren with normal birth weight. Methods: A case-control, retrospective, cross-sectional study conducted with 378 schoolchildren, both genders, aged 5 to 9.9 years, from the municipal schools of Embu das Artes...
October 13, 2016: CoDAS
Mini Mol Menamparambath, Kihyuk Yang, Hyeong Hoon Kim, Oh Seung Bae, Mun Seok Jeong, Jae-Young Choi, Seunghyun Baik
Silver nanowires (Ag NWs) have received considerable attention for flexible transparent conductive films (TCFs) since they provide a relatively low sheet resistance at a high transmittance. However, the diffuse light scattering, haze, has been regarded as a hurdle to achieve clarity of films. Here we revisit the Mie scattering theory to calculate the extinction and scattering coefficients of Ag NWs which were employed to estimate haze of TCFs. The theory predicted a decrease in haze with a decrease in Ag NW diameter which was supported by experimental investigations carried out using Ag NWs with 5 different diameters (17...
October 19, 2016: Nanotechnology
Mie Rostved Rasmussen, Kirstine Lykke Nielsen, Mia Roest Laursen, Camilla Bak Nielsen, Pia Svendsen, Henrik Dimke, Erik Ilsø Christensen, Mogens Johannsen, Søren Kragh Moestrup
Loss-of-function mutations in the transmembrane ABCC6 transport protein cause pseudoxanthoma elasticum - an ectopic, metabolic mineralization disorder affecting the skin, eye and vessels. ABCC6 is assumed to mediate efflux of one or several small molecule compounds from the liver cytosol to the circulation. Untargeted metabolomics using liquid chromatography mass spectrometry was employed to inspect liver cytosolic extracts from mice with targeted disruption of the Abcc6 gene. Absence of the ABCC6 protein induced an altered profile of metabolites in the liver causing accumulation of compounds as more features were upregulated than downregulated in ABCC6-deficient mice...
October 19, 2016: Journal of Proteome Research
Catia Contado, Roberto Argazzi, Vincenzo Amendola
Many advanced industrial and biomedical applications that use silver nanoparticles (AgNPs), require that particles are not only nano-sized, but also well dispersed, not aggregated and not agglomerated. This study presents two methods able to give rapidly sizes of monodispersed AgNPs suspensions in the dimensional range of 20-100nm. The first method, based on the application of Mie's theory, determines the particle sizes from the values of the surface plasmon resonance wavelength (SPRMAX), read from the optical absorption spectra, recorded between 190nm and 800nm...
October 13, 2016: Journal of Chromatography. A
Frans van Workum, Stefan A W Bouwense, Misha D P Luyer, Grard A P Nieuwenhuijzen, Donald L van der Peet, Freek Daams, Ewout A Kouwenhoven, Marc J van Det, Frits J H van den Wildenberg, Fatih Polat, Suzanne S Gisbertz, Mark I van Berge Henegouwen, Joos Heisterkamp, Barbara S Langenhoff, Ingrid S Martijnse, Janneke P Grutters, Bastiaan R Klarenbeek, Maroeska M Rovers, Camiel Rosman
BACKGROUND: Currently, a cervical esophagogastric anastomosis (CEA) is often performed after minimally invasive esophagectomy (MIE). However, the CEA is associated with a considerable incidence of anastomotic leakage requiring reintervention or reoperation and moderate functional results. An intrathoracic esophagogastric anastomosis (IEA) might reduce the incidence of anastomotic leakage, improve functional results and reduce costs. The objective of the ICAN trial is to compare anastomotic leakage and postoperative morbidity, mortality, quality of life and cost-effectiveness between CEA and IEA after MIE...
October 18, 2016: Trials
Zhenyi Chen, Cheng Liu, Wenqing Liu, Tianshu Zhang, Jin Xu
Despite extensive efforts into the characterization of air pollution during the past decade, concurrent real-time characterization of aerosol and NO2 as well as satellite observation above the urban canopy in the megacity of Beijing has sparsely been performed to date. We conducted a simultaneous real-time measurement of aerosol and NO2 in urban Beijing in a pollution episode from November 25, 2015 to December 2, 2015. The aerosol extinction coefficient was measured by a 532 Mie lidar and the NO2 concentration by a Multi-Axis Differential Optical Absorption Spectroscopy (MAX-DOAS)...
October 14, 2016: Science of the Total Environment
Sara Kjaer Bastholm, Mie Hesselund Samson, Naja Becher, Lea Kirstine Hansen, Peter Reimer Stubbe, Ioannis S Chronakis, Ebba Nexo, Niels Uldbjerg
INTRODUCTION: The viscoelastic properties of the cervical mucus plug are considered essential for the occlusion of the cervical canal and thereby for protection against ascending infections during pregnancy. Factors controlling this property are virtually unknown. This study explores a possible role of trefoil factor peptides 1, 2 and 3 (TFF1-3); peptides believed to influence mucus viscosity. MATERIALS AND METHODS: The study is based on spontaneously shed cervical mucus plugs from 14 women in active labor...
October 12, 2016: Acta Obstetricia et Gynecologica Scandinavica
Qi Wang, Zixiang Wu, Gang Chen, Sai Zhang, Gang Shen, Ming Wu
Background Minimally invasive esophagectomy (MIE) Ivor Lewis has been increasingly performed over the last two decades. To guide the implementation of this technically demanding procedure, a comprehensive assessment of MIE-Ivor Lewis learning curves should include both the general competence to accomplish the procedure and the ability to generate oncological benefits. These objectives are believed to be associated with different phases of the learning curve. Methods A retrospective review of the first 109 patients who underwent MIE-Ivor Lewis by a single qualified surgeon was conducted...
October 5, 2016: Thoracic and Cardiovascular Surgeon
Denys Pavlenko, Esmée van Geffen, Mies J van Steenbergen, Griet Glorieux, Raymond Vanholder, Karin G F Gerritsen, Dimitrios Stamatialis
Hemodialysis is a widely available and well-established treatment for patients with End Stage Renal Disease (ESRD). However, although life-sustaining, patient mortality rates are very high. Several recent studies corroborated the link between dialysis patients' outcomes and elevated levels of protein-bound uremic toxins (PBUT) that are poorly removed by conventional hemodialysis. Therefore, new treatments are needed to improve their removal. Recently, our group showed that the combination of dialysis and adsorption on one membrane, the mixed matrix membrane (MMM), can effectively remove those toxins from human plasma...
October 5, 2016: Scientific Reports
Mette Christensen, Rikke Fogt Madsen, Line Rosengreen Møller, Cindy Soendersoe Knudsen, Mie Hessellund Samson
INTRODUCTION: The aim of this study was to investigate and compare the stability of adrenocorticotrophic hormone (ACTH) in whole blood stored on ice and at room temperature for up to 48 hours. This study differs from previous studies by a larger data material. MATERIALS AND METHODS: EDTA-blood samples from 30 patients were collected, aliquoted and stored on ice or at room temperature for 0, 2, 4, 24, or 48 h before centrifugation, and the plasma was stored frozen until analysis...
October 5, 2016: Scandinavian Journal of Clinical and Laboratory Investigation
Michael Rein, Etgar Levy, Alexander Gumennik, Ayman F Abouraddy, John Joannopoulos, Yoel Fink
Fibres with electronic and photonic properties are essential building blocks for functional fabrics with system level attributes. The scalability of thermal fibre drawing approach offers access to large device quantities, while constraining the devices to be translational symmetric. Lifting this symmetry to create discrete devices in fibres will increase their utility. Here, we draw, from a macroscopic preform, fibres that have three parallel internal non-contacting continuous domains; a semiconducting glass between two conductors...
October 4, 2016: Nature Communications
F G Mitri
Hermite-Gaussian (HGl) acoustical-sheets are introduced and their beamforming properties are examined. A general nonparaxial mathematical solution for the incident beam of any order l is derived based on the angular spectrum decomposition in plane waves. The beam-shape coefficients characterizing the incident beam in cylindrical coordinates are expressed in an integral form and computed using the standard numerical integration procedure based on the trapezoidal rule. The analysis is further extended to calculate the longitudinal and transverse acoustic radiation force functions as well as the axial radiation torque function for a viscous fluid cylindrical cross-section submerged in a non-viscous fluid and located arbitrarily in space in the field of the HGl beams in the Rayleigh and resonance (Mie) regimes...
September 20, 2016: Ultrasonics
Mie K Lam, Chris J G Bakker, Chrit T W Moonen, Max A Viergever, Lambertus W Bartels
The MR time-signal behavior of water has been reported to be different on short and long time scales for systems of randomly distributed perturbers in water in the static dephasing regime. Up to now, the signal of the perturbers in such systems has not been taken into consideration. Water-fat emulsions are macroscopically homogeneous systems and can be considered as microscopically randomly distributed perturbing fat spheres embedded in water. In such water-fat systems, the signal of the perturber, fat, cannot be ignored...
September 30, 2016: NMR in Biomedicine
Frans van Workum, Jolijn van der Maas, Frits J H van den Wildenberg, Fatih Polat, Ewout A Kouwenhoven, Marc J van Det, Grard A P Nieuwenhuijzen, Misha D Luyer, Camiel Rosman
BACKGROUND: Both cervical esophagogastric anastomosis (CEA) and intrathoracic esophagogastric anastomosis (IEA) are used to restore gastrointestinal integrity following minimally invasive esophagectomy (MIE). No prospective randomized data on functional outcome, postoperative morbidity, and mortality between these techniques are currently available. METHODS: A comparison was conducted including all consecutive patients with esophageal carcinoma of the distal esophagus or gastroesophageal junction undergoing MIE with CEA or MIE with IEA from October 2009 to July 2014 in 3 high-volume esophageal cancer centers...
September 24, 2016: Annals of Thoracic Surgery
José M Caridad, Stephen Connaughton, Christian Ott, Heiko B Weber, Vojislav Krstić
Mie scattering is an optical phenomenon that appears when electromagnetic waves, in particular light, are elastically scattered at a spherical or cylindrical object. A transfer of this phenomenon onto electron states in ballistic graphene has been proposed theoretically, assuming a well-defined incident wave scattered by a perfectly cylindrical nanometer scaled potential, but experimental fingerprints are lacking. We present an experimental demonstration of an electrical analogue to Mie scattering by using graphene as a conductor, and circular potentials arranged in a square two-dimensional array...
2016: Nature Communications
Silvan Francke, Anna Mies, Manja Meggendorfer, Uta Oelschlaegel, Ekaterina Balaian, Silke Gloaguen, Torsten Haferlach, Gerhard Ehninger, Martin Bornhäuser, Uwe Platzbecker
No abstract text is available yet for this article.
September 23, 2016: Leukemia & Lymphoma
O O Olujimi, G R E E Ana, O O Ogunseye, V T Fabunmi
Charcoal production is often accompanied with gaseous and particulate emission into the atmosphere and occupationally exposed workers could be affected. This cross sectional comparative study was carried out to assess the levels of carbon monoxide (CO), carbon dioxide (CO2), sulphur dioxide (SO2), nitrogen dioxide (NO2) and particulate matter (PM2.5) generated during the phases of charcoal production and their relationship with certain biomarkers among charcoal workers (subjects) and non-charcoal workers (controls) such as carboxyhaemoglobin (COHb), forced expiratory volume in the first second of expiration (FEV1), peak expiratory flow rate (PEFR) and body mass index (BMI) in Igbo-Ora, Oyo State and Alabata, Ogun State, which are two of the major hubs of charcoal production in South Western Nigeria...
2016: SpringerPlus
Ragip A Pala, Serkan Butun, Koray Aydin, Harry A Atwater
Light trapping in planar ultrathin-film solar cells is limited due to a small number of optical modes available in the thin-film slab. A nanostructured thin-film design could surpass this limit by providing broadband increase in the local density of states in a subwavelength volume and maintaining efficient coupling of light. Here we report a broadband metasurface design, enabling efficient and broadband absorption enhancement by direct coupling of incoming light to resonant modes of subwavelengthscale Mie nanoresonators defined in the thin-film active layer...
2016: Scientific Reports
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