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https://www.readbyqxmd.com/read/28813186/multi-normalization-and-interpolation-protocol-to-improve-norovirus-immunoagglutination-assay-from-paper-microfluidics-with-smartphone-detection
#1
Soohee Cho, Tu San Park, Kelly A Reynolds, Jeong-Yeol Yoon
Norovirus (NoV) is one of the leading causes of acute gastroenteritis, affecting 685 million people per year around the world. The best preventive measure is to screen water for possible NoV contamination, not from infected humans, preferably using rapid and field-deployable diagnostic methods. While enzyme immunoassays (EIAs) can be used for such detection, the low infectious dose as well as the generally inferior sensitivity and low titer of available NoV antibodies render critical challenges in using EIAs toward NoV detection...
August 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/28804991/nf-%C3%AE%C2%BAb2-controls-migratory-activity-of-memory-t-cells-by-regulating-expression-of-cxcr4-in-a-mouse-model-of-sj%C3%A3-gren-s-syndrome
#2
Mie Kurosawa, Rieko Arakaki, Akiko Yamada, Takaaki Tsunematsu, Yasusei Kudo, Jonathan Sprent, Naozumi Ishimaru
OBJECTIVE: Dysregulated chemokine signaling contributes to autoimmune diseases by facilitating aberrant T-cell infiltration into target tissues, but the specific chemokines, receptors, and T-cell populations remain largely unidentified. Role of the potent chemokine CXCL12 and its receptor CXCR4 in T-cell autoimmune response was examined using alymphoplasia (aly)/aly mice, a Sjögren's syndrome (SS) model. METHODS: T-cell phenotypes in the salivary gland of aly/aly mice were evaluated using immunological analysis...
August 13, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28796480/refractive-index-tuning-of-highly-fluorescent-carbon-dots
#3
Vijay Bhooshan Bhooshan Kumar, Amit Sahu, Xiangping Li, Abu Moshin, Aharon Gedanken
In this manuscript, we report the refractive-index (RI) modulation of various concentrations of nitrogen-doped carbon dots (N@C-dots) embedded in poly(vinyl alcohol) (PVA) polymer. The dispersion and size distribution of N@C-dots embedded within PVA have been investigated using electron microscopy. The RI of PVA-N@C-dots can be enhanced by increasing the doping concentration of highly-fluorescent C-dots (quantum yield 44%). This is demonstrated using ultraviolet-visible (UV-visible), photoluminscence, Raman, and Fourier transform infrared (FTIR) spectroscopy measurements...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28796016/a-propensity-score-matched-analysis-of-open-versus-minimally-invasive-transthoracic-esophagectomy-in-the-netherlands
#4
Maarten F J Seesing, Suzanne S Gisbertz, Lucas Goense, Richard van Hillegersberg, Hidde M Kroon, Sjoerd M Lagarde, Jelle P Ruurda, Annelijn E Slaman, Mark I van Berge Henegouwen, Bas P L Wijnhoven
OBJECTIVE: The aim of this study was to compare open esophagectomy (OE) with minimally invasive esophagectomy (MIE) in a population-based setting. BACKGROUND: Randomized controlled trials and cohort studies have shown that MIE is associated with reduced pulmonary complications and shorter hospital stay as compared to OE. METHODS: Patients who underwent transthoracic esophagectomy for cancer between 2011 and 2015 were selected from the national Dutch Upper Gastrointestinal Cancer Audit...
August 8, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28795336/the-ever-evolving-role-of-pathologists-in-the-management-of-breast-cancer-with-neoadjuvant-treatment-recommendations-based-on-the-spanish-clinical-experience
#5
O Burgués, Mª Á López-García, B Pérez-Míes, P Santiago, B Vieites, J F García, V Peg
PURPOSE: To compare the current international standards for neoadjuvant systemic therapy (NAST) protocols, and establish consensus recommendations by Spanish breast pathologists; and to look into the Spanish reality of defining pathological complete response in daily practice. MATERIALS AND METHODS: A modified Delphi technique was used to gain consensus among a panel of 46 experts with regard to important issues about NAST specimens, with the objective of standardize handling and analysis of these breast cancer specimens...
August 9, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28792669/an-improved-algorithm-for-fast-resonant-mie-scatter-correction-of-infrared-spectra-of-cells-and-tissues
#6
Tatiana Konevskikh, Rozalia Lukacs, Achim Kohler
Mie scattering effects create serious problems for the interpretation of FTIR spectra of single cells and tissues. During recent years, different techniques were proposed to retrieve pure absorbance spectra from spectra with Mie distortions. Recently, we published an iterative algorithm for correcting Mie scattering in spectra of single cells and tissues, which we called 'the fast resonant Mie scatter correction algorithm'. The algorithm is based on extended multiplicative signal correction (EMSC) and employs a meta-model for a parameter range of refractive index and size parameters...
August 9, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28791965/design-of-bfgf-tethered-self-assembling-extracellular-matrix-proteins-via-coiled-coil-triple-helix-formation
#7
Yoshinori Mizuguchi, Yasumasa Mashimo, Masayasu Mie, Eiry Kobatake
Self-assembling peptides are attractive materials for tissue engineering applications because of their functionality including high biocompatibility and biodegradability. Modification of self-assembling peptides with functional motifs, such as the cell-adhesive tripeptide sequence RGD leads to functional artificial extracellular matrices (ECMs). In this study, we developed an artificial self-assembling ECM protein tethered with a growth factor via heterotrimer triple-helix (helix A/B/C) formation. The helix A and helix C peptides, which are capable of forming a heterodimer coiled-coil structure, were fused to both ends of a matrix protein composed of the elastin-derived structural unit (APGVGV)12 with an RGD motif...
August 9, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28774153/properties-of-longitudinal-electromagnetic-oscillations-in-metals-and-their-excitation-at-planar-and-spherical-surfaces
#8
Vitaly V Datsyuk, Oleg R Pavlyniuk
The common definition of the spatially dispersive permittivity is revised. The response of the degenerate electron gas on an electric field satisfying the vector Helmholtz equation is found with a solution to the Boltzmann equation. The calculated longitudinal dielectric function coincides with that obtained by Klimontovich and Silin in 1952 and Lindhard in 1954. However, it depends on the square of the wavenumber, a parameter of the vector Helmholtz equation, but not the wave vector of a plane electromagnetic wave...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28773241/mie-metamaterials-based-thermal-emitter-for-near-field-thermophotovoltaic-systems
#9
Alok Ghanekar, Yanpei Tian, Sinong Zhang, Yali Cui, Yi Zheng
In this work, we theoretically analyze the performance characteristics of a near-field thermophotovoltaic system consisting a Mie-metamaterial emitter and GaSb-based photovoltaic cell at separations less than the thermal wavelength. The emitter consists of a tungsten nanoparticle-embedded thin film of SiO 2 deposited on bulk tungsten. Numerical results presented here are obtained using formulae derived from dyadic Green's function formalism and Maxwell-Garnett-Mie theory. We show that via the inclusion of tungsten nanoparticles, the thin layer of SiO 2 acts like an effective medium that enhances selective radiative heat transfer for the photons above the band gap of GaSb...
July 31, 2017: Materials
https://www.readbyqxmd.com/read/28767662/dust-concentration-measurement-based-on-mie-scattering-of-a-laser-beam
#10
Xiaoyu Yu, Yunbo Shi, Tian Wang, Xu Sun
To realize automatic measurement of the concentration of dust particles in the air, a theory for dust concentration measurement was developed, and a system was designed to implement the dust concentration measurement method based on laser scattering. In the study, the principle of dust concentration detection using laser scattering is studied, and the detection basis of Mie scattering theory is determined. Through simulation, the influence of the incident laser wavelength, dust particle diameter, and refractive index of dust particles on the scattered light intensity distribution are obtained for determining the scattered light intensity curves of single suspended dust particles under different characteristic parameters...
2017: PloS One
https://www.readbyqxmd.com/read/28764465/enhancing-monochromatic-multipole-emission-by-a-subwavelength-enclosure-of-degenerate-mie-resonances
#11
Jiajun Zhao, Likun Zhang, Ying Wu
Sound emission is inefficient at low frequencies as limited by source size. This letter presents enhancing emission of monochromatic monopole and multipole sources by enclosing the source with a subwavelength circular enclosure filled of an anisotropic material of a low radial sound speed. The anisotropy is associated with an infinite tangential density along the azimuth. Numerical simulations show that emission gain is produced at frequencies surrounding degenerate Mie resonant frequencies of the enclosure, and meanwhile the radiation directivity pattern is well preserved...
July 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28761964/hyperhidrosis-substantially-reduces-quality-of-life-in-children-a-retrospective-study-describing-symptoms-consequences-and-treatment-with-botulinum-toxin
#12
Sandra Eriksson Mirkovic, Alma Rystedt, Mie Balling, Carl Swartling
Studies on children with hyperhidrosis are sparse. This retrospective study presents clinical data and quality of life, along with treatment effect and safety of botulinum toxin (BTX). Case reports from 366 children were included to capture the medical history of hyperhidrosis. The total median score of the Dermatology Life Quality Index before treatment was 11 for children aged 16-17 years and 12 for children younger than 16 years. The children described physical, psychosocial and consequence-related symptoms...
August 1, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28760942/perivascular-adipose-tissue-angiotensin-ii-type-1-receptor-promotes-vascular-inflammation-and-aneurysm-formation
#13
Tomoki Sakaue, Jun Suzuki, Mika Hamaguchi, Chika Suehiro, Akiko Tanino, Tomoaki Nagao, Teruyoshi Uetani, Jun Aono, Hirotomo Nakaoka, Mie Kurata, Tomohisa Sakaue, Takafumi Okura, Takumi Yasugi, Hironori Izutani, Jitsuo Higaki, Shuntaro Ikeda
Perivascular adipose tissue exhibits characteristics of active local inflammation, which contributes to the development of atherosclerotic disease as a complication of obesity/metabolic syndrome. However, the precise role of perivascular adipose tissue in the progression of abdominal aortic aneurysm remains unclear. To test the hypothesis that genetic deletion of angiotensin II type 1a (AT1a) receptor in perivascular visceral adipose tissue (VAT) can attenuate aortic aneurysm formation in apolipoprotein E-deficient (ApoE(-/-)) mice, we performed adipose tissue transplantation experiments by using an angiotensin II-induced aneurysm murine model, in which we transplanted VAT from ApoE(-/-) or ApoE(-/-) AT1a(-/-) donor mice onto the abdominal aorta of ApoE(-/-) recipient mice...
July 31, 2017: Hypertension
https://www.readbyqxmd.com/read/28760856/normal-and-malignant-cells-exhibit-differential-responses-to-calcium-electroporation
#14
Stine K Frandsen, Mie B Krüger, Uma M Mangalanathan, Trine Tramm, Faisal Mahmood, Ivana Novak, Julie Gehl
Calcium electroporation may offer a simple general tool for anticancer therapy. Transient permeabilization of cancer cell membranes created by applying short, high-voltage pulses in tumors enables high calcium influxes that trigger cell death. In this study, we compared the relative sensitivity of different human tumor models and normal tissues to calcium electroporation. Plasma membrane Ca(2+)-ATPase (PMCA) protein expression was confirmed in vitro in all cancer cell lines and normal primary dermal fibroblasts studied...
August 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28760463/survival-after-esophagectomy-a-propensity-matched-study-of-different-surgical-approaches
#15
Benny Weksler, Jennifer L Sullivan
BACKGROUND: Although open esophagectomy (OE) is considered the "gold standard" treatment for esophageal cancer, robotic-assisted minimally invasive esophagectomy (RAMIE), and laparoscopic/thoracoscopic minimally invasive esophagectomy (MIE) are becoming more common. This study aimed to compare short-term outcomes and overall survival of patients undergoing RAMIE, MIE, and OE. METHODS: The National Cancer Data Base was queried for patients who had OE, RAMIE, or MIE for esophageal cancer from 2010 to 2013...
July 28, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28752672/risk-factors-for-stomatitis-in-patients-with-lymphangioleiomyomatosis-during-treatment-with-sirolimus-a-multicenter-investigator-initiated-prospective-study
#16
Nobutaka Kitamura, Kuniaki Seyama, Yoshikazu Inoue, Katsura Nagai, Masaru Suzuki, Hiroshi Moriyama, Toshinori Takada, Ryushi Tazawa, Toyohiro Hirai, Michiaki Mishima, Mie Hayashida, Masaki Hirose, Toru Arai, Chikatoshi Sugimoto, Noboru Hattori, Kentaro Watanabe, Tsutomu Tamada, Kohei Akazawa, Takahiro Tanaka, Koh Nakata
PURPOSE: Lymphangioleiomyomatosis is a rare lung disease caused by proliferation of abnormal smooth muscle-like cells and typically occurs in premenopausal women. Sirolimus is now the first-line drug for the treatment of lymphangioleiomyomatosis. Sirolimus-induced stomatitis is the most frequent adverse event experienced during treatment. To identify risk factors, we investigated the association of stomatitis incidence with patient background data and treatment parameters, using data from the multicenter long-term sirolimus trial...
July 28, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28744192/macroanatomical-landmarks-featuring-junctions-of-major-sulci-and-fissures-and-scalp-landmarks-based-on-the-international-10-10-system-for-analyzing-lateral-cortical-development-of-infants
#17
Daisuke Tsuzuki, Fumitaka Homae, Gentaro Taga, Hama Watanabe, Mie Matsui, Ippeita Dan
The topographic relationships between the macroanatomical structure of the lateral cortex, including sulci and fissures, and anatomical landmarks on the external surface of the head are known to be consistent. This allows the coregistration of EEG electrodes or functional near-infrared spectroscopy over the scalp with underlying cortical regions. However, limited information is available as to whether the topographic relationships are maintained in rapidly developing infants, whose brains and heads exhibit drastic growth...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28742959/long-range-corrections-for-inhomogeneous-simulations-of-mie-n-m-potential
#18
Jiri Janecek, Olivier Said-Aizpuru, Patrice Paricaud
The long range correction scheme for dispersion interactions in inhomogeneous simulations is generalized to Mie n - m potential. The influence of the cut-off distance and lateral dimensions of the simulation box are studied for 8 - 6 , 12 - 6 and 20 - 6 Mie fluids at two different temperatures (close and far from the critical point). For sufficiently large systems (2400 particles, Rc = 3.5σ) equilibrium properties are simulated over the whole vapour - liquid coexistence using the inhomogeneous Monte Carlo simulations and the results are compared with the Gibbs Ensemble technique and with the square gradient theory combined with the SAFT Mie equation of state...
July 25, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28738691/selective-cephalic-upregulation-of-p-erk-camkii-and-p-creb-in-response-to-glyceryl-trinitrate-infusion
#19
Roshni Ramachandran, Sara Hougaard Pedersen, Dipak Vasantrao Amrutkar, Steffen Petersen, Julie Mie Jacobsen, Anders Hay-Schmidt, Jes Olesen, Inger Jansen-Olesen
Background A common characteristic of migraine-inducing substances is that they cause headache and no pain in other areas of the body. Few studies have compared pain mechanisms in the trigeminal and spinal systems and, so far, no major differences have been noted. We compared signalling molecules in the trigeminal and spinothalamic system after infusion of the migraine-provoking substance glyceryltrinitrate. Method A catheter was placed in the femoral vein of rats and one week later glyceryltrinitrate 4 µg/kg/min was infused for 20 min...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28735922/prevalence-of-restless-legs-syndrome-and-associated-factors-in-an-otherwise-healthy-population-results-from-the-danish-blood-donor-study
#20
Maria Didriksen, Andreas S Rigas, Richard P Allen, Brendan J Burchell, Emanuele Di Angelantonio, Maria H Nielsen, Poul Jennum, Thomas Werge, Christian Erikstrup, Ole B Pedersen, Mie T Bruun, Kristoffer S Burgdorf, Erik Sørensen, Henrik Ullum
OBJECTIVE: Restless legs syndrome (RLS) is a neurological sensorimotor disorder characterized by uncomfortable sensations in the legs. RLS often occurs as a comorbid condition. Besides an increased risk of iron deficiency, blood donors are considered to be generally healthy. Blood donors are therefore an ideal population for studying factors associated with RLS occurrence, herein the role of iron. It is suggested that RLS is linked to sex, age, low socioeconomic status, unhealthy lifestyle, and iron deficiency...
August 2017: Sleep Medicine
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