keyword
https://read.qxmd.com/read/38546197/the-myelination-associated-g-protein-coupled-receptor-37-is-regulated-by-zfp488-nkx2-2-and-sox10-during-oligodendrocyte-differentiation
#21
JOURNAL ARTICLE
Antonia L Schmidt, Marco Kremp, Takaaki Aratake, Siying Cui, Yifeng Lin, Xiaowen Zhong, Q Richard Lu, Chengfu Zhang, Mengsheng Qiu, Tim Aberle, Michael Wegner
Oligodendrocyte differentiation and myelination in the central nervous system are controlled and coordinated by a complex gene regulatory network that contains several transcription factors, including Zfp488 and Nkx2.2. Despite the proven role in oligodendrocyte differentiation little is known about the exact mode of Zfp488 and Nkx2.2 action, including their target genes. Here, we used overexpression of Zfp488 and Nkx2.2 in differentiating CG4 cells to identify aspects of the oligodendroglial expression profile that depend on these transcription factors...
March 28, 2024: Glia
https://read.qxmd.com/read/38546054/a-crosstalk-between-the-receptor-tyrosine-kinase-like-orphan-receptors-ror1-2-and-s1p-signaling-pathways-in-lung-cancer
#22
JOURNAL ARTICLE
Rajeev Nema, Ritu Pandey, Ashok Kumar
OBJECTIVE: Availability of multimodal treatment strategies, including targeted therapies and immunotherapies, have improved the survival of non-small cell lung carcinoma (NSCLC). However, some patients still progress or respond poorly due to inherent resistance, acquired resistance, or lack of druggable driver mutations. Sphingosine-1-phosphate (S1P) and receptor tyrosine kinase-like orphan receptor (ROR1/2) signaling pathways are activated during lung carcinogenesis. METHODS: In this study, we have evaluated the crosstalk of S1P and ROR1/2 signaling pathways in lung cancer cells...
March 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38546046/a-transcriptional-cascade-mediated-by-two-apetala2-family-members-orchestrates-carotenoid-biosynthesis-in-tomato
#23
JOURNAL ARTICLE
Xiaoqing He, Kaidong Liu, Yi Wu, Weijie Xu, Ruochen Wang, Julien Pirrello, Mondher Bouzayen, Mengbo Wu, Mingchun Liu
Carotenoids are important nutrients for human health that must be obtained from plants since they cannot be biosynthesized by the human body. Dissecting the regulatory mechanism of carotenoid metabolism in plants represents the first step toward manipulating carotenoid contents in plants by molecular design breeding. In this study, we determined that SlAP2c, an APETALA2 (AP2) family member, acts as a transcriptional repressor to regulate carotenoid biosynthesis in tomato (Solanum lycopersicum). Knockout of SlAP2c in both the "MicroTom" and "Ailsa Craig" backgrounds resulted in greater lycopene accumulation, whereas overexpression of this gene led to orange-ripe fruit with significantly lower lycopene contents than the wild type...
March 28, 2024: Journal of Integrative Plant Biology
https://read.qxmd.com/read/38545802/mirna-research-the-potential-for-understanding-the-multiple-facets-of-anorexia-nervosa
#24
JOURNAL ARTICLE
Clara Voelz, Stefanie Trinh, Larissa Käver, Mai-Tam Tran, Cordian Beyer, Jochen Seitz
Anorexia nervosa (AN) has a multifaceted and complex pathology, yet major gaps remain in our understanding of factors involved in AN pathology. MicroRNAs (miRNAs) play a regulatory role in translating genes into proteins and help understand and treat diseases. An extensive literature review on miRNAs with AN and comorbidities has uncovered a significant lack in miRNA research. To demonstrate the importance of understanding miRNA deregulation, we surveyed the literature on depression and obesity providing examples of relevant miRNAs...
March 28, 2024: International Journal of Eating Disorders
https://read.qxmd.com/read/38545788/zip-code-to-genomic-code-neighborhood-disadvantage-aggressive-breast-cancer-biology-and-breast-cancer-outcomes
#25
JOURNAL ARTICLE
Neha Goel, Alexandra E Hernandez, Michael H Antoni, Susan Kesmodel, Paulo S Pinheiro, Erin Kobetz, Nipun Merchant, Steve Cole
OBJECTIVE: To determine the association between objective (geospatial) and subjective (perceived) measures of neighborhood disadvantage (ND) and aggressive breast cancer (BCa) tumor biology, defined using validated social adversity-associated transcription factor (TF) activity and clinical outcomes. SUMMARY BACKGROUND DATA: ND is associated with shorter BCa recurrence-free survival (RFS), independent of individual, tumor, and treatment characteristics, suggesting potential unaccounted biological mechanisms by which ND influences RFS...
March 28, 2024: Annals of Surgery
https://read.qxmd.com/read/38545780/genetic-and-epigenetic-mechanisms-regulating-blood-pressure-and-kidney-dysfunction
#26
REVIEW
Kailash N Pandey
The pioneering work of Dr Lewis K. Dahl established a relationship between kidney, salt, and high blood pressure (BP), which led to the major genetic-based experimental model of hypertension. BP, a heritable quantitative trait affected by numerous biological and environmental stimuli, is a major cause of morbidity and mortality worldwide and is considered to be a primary modifiable factor in renal, cardiovascular, and cerebrovascular diseases. Genome-wide association studies have identified monogenic and polygenic variants affecting BP in humans...
March 28, 2024: Hypertension
https://read.qxmd.com/read/38545694/internal-m-6-a-and-m-7-g-rna-modifications-in-hematopoietic-system-and-acute-myeloid-leukemia
#27
JOURNAL ARTICLE
Xiaoxu Zhang, Yanni Ma, Jia Yu, Rui Su, Xiaoshuang Wang
Epitranscriptomics focuses on RNA modifications-mediated post-transcriptional regulation of gene expression. The current decade has witnessed tremendous progress in understanding the landscapes and biological functions of RNA modifications as prompted by potent analytical approaches. The hematopoietic system provides a lifelong supply of blood cells, and gene expression is tightly modulated during the differentiation of hematopoietic stem cells (HSCs). Dysregulation of gene expression during hematopoiesis may lead to severe disorders, including acute myeloid leukemia (AML)...
March 28, 2024: Chinese Medical Journal
https://read.qxmd.com/read/38545416/editorial-transcriptional-and-epigenetic-regulation-in-normal-and-aberrant-hematopoiesis
#28
EDITORIAL
Jonas S Jutzi, Ruud Delwel, Robert Zeiser, Anna E Marneth
No abstract text is available yet for this article.
2024: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/38545384/dual-rna-seq-of-maize-and-h-seropedicae-zae94-association-in-different-doses-of-nitrate-reveals-novel-insights-into-plant-pgpb-environment-relationship
#29
JOURNAL ARTICLE
Aline Cardozo Rosman, Maria Clara de Oliveira Urquiaga, Flávia Thiebaut, Helkin Giovani Forero Ballesteros, Eduardo Alves Gamosa de Oliveira, Adriana Silva Hemerly
The interactions between plants, beneficial bacteria and their environment are profoundly shaped by various environmental factors, including light, temperature, water availability, and soil quality. Despite efforts to elucidate the molecular mechanisms involved in the association between plants and beneficial bacteria, like Plant Growth-Promoting Bacteria (PGPB), with many studies focusing on the transcriptional reprogramming in the plant, there is no report on the modulation of genetic controls from both plant and associated bacteria standpoints, in response to environment...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38545383/multi-omics-analysis-of-pigmentation-related-to-proanthocyanidin-biosynthesis-in-brown-cotton-gossypium-hirsutum-l
#30
JOURNAL ARTICLE
Doug J Hinchliffe, Marina Naoumkina, Gregory N Thyssen, Sunghyun Nam, SeChin Chang, Jack C McCarty, Johnie N Jenkins
Naturally-colored brown cotton (NBC) fiber is an environmentally friendly raw source of fiber for textile applications. The fiber of some NBC cultivars exhibits flame-retardant properties, which can be used in textiles that require flame resistance. Proanthocyanidins or their derivatives are responsible for the brown pigment in NBC; however, how flame retardancy is related to pigmentation in NBC is poorly understood. To gain insight into brown pigment biosynthesis, we conducted comparative transcripts and metabolites profiling analysis of developing cotton fibers between the brown (MC-BL) and white (MC-WL) cotton near-isogenic lines (NILs), genetically different only in the Lc1 locus...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38545256/jak3-stat5-signaling-triggered-upregulation-of-pik3cd-contributes-to-gastric-carcinoma-development
#31
JOURNAL ARTICLE
Qingqing Hu, Ning Dou, Qiong Wu, Yong Gao, Yandong Li, Jingde Chen
Gastric cancer (GC) is one of the most common solid cancers with high incidence and mortality worldwide. Chronic gastritis and consequent inflammatory microenvironment is known as a major cause leading to gastric carcinogenesis. Here we report that PIK3CD that encodes p110δ, a catalytic subunit of the class IA PI3Ks, is overexpressed and tumorigenic in GC and associated with tumor inflammatory microenvironment. By investigating the data from TCGA database and our immunohistochemical staining and quantitative real-time PCR results from clinical samples, we found PIK3CD exhibits higher expression level in GC tissues compared with adjacent non-tumorous stomach tissues...
March 2024: Journal of Cell Communication and Signaling
https://read.qxmd.com/read/38545201/probiotic-derived-ferrichrome-induces-ddit3-mediated-antitumor-effects-in-esophageal-cancer-cells
#32
JOURNAL ARTICLE
Takehito Kunogi, Hiroaki Konishi, Aki Sakatani, Kentaro Moriichi, Chikage Yamamura, Koji Yamamoto, Shin Kashima, Katsuyoshi Ando, Nobuhiro Ueno, Hiroki Tanaka, Toshikatsu Okumura, Mikihiro Fujiya
Esophageal cancer, which is common among the elderly, has the poorest prognosis among gastrointestinal cancers. Previously, we demonstrated that ferrichrome, produced by the probiotic Lactobacillus casei , exhibited anti-tumor effects in various gastrointestinal cancers, including colorectal and gastric cancers, with minimal effects on non-cancerous intestinal cells. However, it remains unclear whether ferrichrome exerts anti-tumor effects in esophageal cancer. A sulforhodamine B assay revealed that ferrichrome suppressed esophageal adenocarcinoma (OE33, OE19) and squamous cell carcinoma (KYSE70) cells...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38545150/identification-and-expression-analysis-of-tps-family-gene-in-cannabis-sativa-l
#33
JOURNAL ARTICLE
Jiao Xu, Lingyang Kong, Weichao Ren, Zhen Wang, Lili Tang, Wei Wu, Xiubo Liu, Wei Ma, Shuquan Zhang
Terpene synthases ( TPSs ) regulate plant growth, development, and stress response. TPS genes have been identified in Arabidopsis thaliana and Zea mays . Cannabis sativa TPS genes were identified and analyzed using bioinformatics. Genomic data were downloaded from Plant Transcription Factor Database and National Center for Biotechnology Information database, and TPS genes were predicted, analyzed, and visualized using ExPASy, PlantCare, and other online websites along with TBtools, MEGA software, and other software...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38545103/host-functionalization-of-macrin-nanoparticles-to-enable-drug-loading-and-control-tumor-associated-macrophage-phenotype
#34
JOURNAL ARTICLE
Biplab Sarkar, Sean P Arlauckas, Michael F Cuccarese, Christopher S Garris, Ralph Weissleder, Christopher B Rodell
Macrophages are critical regulators of the tumor microenvironment and often present an immuno-suppressive phenotype, supporting tumor growth and immune evasion. Promoting a robust pro-inflammatory macrophage phenotype has emerged as a therapeutic modality that supports tumor clearance, including through synergy with immune checkpoint therapies. Polyglucose nanoparticles (macrins), which possess high macrophage affinity, are useful vehicles for delivering drugs to macrophages, potentially altering their phenotype...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38544909/targeting-nuclear-receptors-for-nash-mash-from-bench-to-bedside
#35
JOURNAL ARTICLE
Rohit A Sinha
The onset of metabolic dysfunction-associated steatohepatitis (MASH) or non-alcoholic steatohepatitis (NASH) represents a tipping point leading to liver injury and subsequent hepatic complications in the natural progression of what is now termed metabolic dysfunction-associated steatotic liver diseases (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD). With no pharmacological treatment currently available for MASH/NASH, the race is on to develop drugs targeting multiple facets of hepatic metabolism, inflammation, and pro-fibrotic events, which are major drivers of MASH...
March 2024: Liver Research
https://read.qxmd.com/read/38544837/emerging-role-of-m6a-modification-in-ovarian-cancer-progression-drug-resistance-and-therapeutic-prospects
#36
REVIEW
Shahil Alam, Pankaj Kumar Giri
Ovarian Cancer (OC) ranks as a prominent contributor to mortality among female reproductive system associated cancers, particularly the prevalent subtype epithelial Ovarian Cancer (EOC). Despite advancements in treatment modalities, the prognosis for OC patients remains grim due to limitation of current therapeutic methodology such as high cytotoxicity of chemotherapeutic agents and tumor relapse making existing chemotherapy ineffective. Recognizing the limitations of a broad-spectrum approach to treating OC, a shift toward targeted therapies aligning with unique molecular features is imperative...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38544741/-cmpx-overexpression-in-pseudomonas-aeruginosa-affects-biofilm-formation-and-cell-morphology-in-response-to-shear-stress
#37
JOURNAL ARTICLE
Audrey David, Mélissande Louis, Ali Tahrioui, Sophie Rodrigues, Clarisse Labbé, Olivier Maillot, Magalie Barreau, Olivier Lesouhaitier, Pierre Cornelis, Sylvie Chevalier, Emeline Bouffartigues
UNLABELLED: Pseudomonas aeruginosa is an opportunistic pathogen causing chronic infections that are related to its ability to form biofilms. Mechanosensitive ion channels (Mcs) are cytoplasmic membrane proteins whose opening depends on a mechanical stress impacting the lipid bilayer. CmpX is a homologue of the small conductance MscS of Escherichia coli . The cmpX gene is part of a transcriptional cfrX-cmpX unit that is under the control of the cell envelope stress response ECF sigma factor SigX...
June 2024: Biofilm
https://read.qxmd.com/read/38544565/sgms1-facilitates-osteogenic-differentiation-of-mscs-and-strengthens-osteogenesis-angiogenesis-coupling-by-modulating-cer-pp2a-akt-pathway
#38
JOURNAL ARTICLE
Kai Yang, Ying-Yi Luan, Shan Wang, You-Sheng Yan, Yi-Peng Wang, Jue Wu, Yong-Qing Sun, Jing Zhang, Wen-Qi Chen, Yu-Lan Xiang, Ze-Lu Li, Dong-Liang Zhang, Cheng-Hong Yin
Mesenchymal stem cell (MSC)-mediated coupling of osteogenesis and angiogenesis is a critical phenomenon in bone formation. Herein, we investigated the role and mechanism of SGMS1 in the osteogenic differentiation of MSCs and, in combination with osteogenesis and angiogenesis, to discover new therapeutic targets for skeletal dysplasia and bone defects. SGMS1 addition accelerated MSC osteogenic differentiation, whereas SGMS1 silencing suppressed this process. Moreover, SGMS1 overexpression inhibited ceramide (Cer) and promoted sphingomyelin (SM) levels...
April 19, 2024: IScience
https://read.qxmd.com/read/38544560/cnpy2-governs-pdgf%C3%A2-bb%C3%A2-treated-vascular-smooth-muscle-cell-proliferation-migration-and-phenotypic-transformation-via-the-akt-mtor-gsk%C3%A2-3%C3%AE-signaling-pathway
#39
JOURNAL ARTICLE
Houqi Sun, Xuejie Wang, Ling Ma, Xu Li, Wenjing Jin, Yongbin Yang
Phenotype switching of vascular smooth muscle cells (VSMCs) is a pathological process in various vascular diseases. Canopy FGF signaling regulator 2 (CNPY2) has previously been found to be abnormally expressed in ApoE-/- mice and aortic endothelial cells, indicating it may have an important role in vascular diseases. The present study aimed to determine the role and mechanism of CNPY2 in VSMC phenotype switching. Following stimulation with platelet-derived growth factor type BB (PDGF-BB), the expression of CNPY2 in VSMCs was detected using reverse transcription-quantitative PCR and western blot analysis...
May 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38544552/identification-and-application-of-an-exocarp-preferential-promoter-for-genetic-engineering-of-tomato-fruit
#40
JOURNAL ARTICLE
Xue-Ming Ruan, Xiangyu Xiong, Jian-Feng Li
Tomato ( Solanum lycopersicum ) is a globally cultivated crop with great economic value. The exocarp determines the appearance of tomato fruit and protects it from various biotic and abiotic challenges at both pre-harvest and post-harvest stages. However, no tomato exocarp-specific promoter is currently available, which hinders exocarp-based genetic engineering. Here, we identified by RNA sequencing and reverse transcription-quantitative PCR analyses that the tomato gene SlPR10 ( PATHOGENESIS RELATED 10 ) was abundantly and predominantly expressed in the exocarp...
March 2024: Horticulture Research
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