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https://www.readbyqxmd.com/read/29285809/investigation-of-the-bold-and-cbv-fmri-responses-to-somatosensory-stimulation-in-awake-marmosets-callithrix-jacchus
#1
Yoshiyuki Hirano, Cecil C Yen, Junjie V Liu, Julie B Mackel, Hellmut Merkle, George C Nascimento, Bojana Stefanovic, Afonso C Silva
Understanding the spatiotemporal features of the hemodynamic response function (HRF) to brain stimulation is essential for the correct application of neuroimaging methods to study brain function. Here, we investigated the spatiotemporal evolution of the blood oxygen level-dependent (BOLD) and cerebral blood volume (CBV) HRF in conscious, awake marmosets (Callithrix jacchus), a New World non-human primate with a lissencephalic brain and with growing use in biomedical research. The marmosets were acclimatized to head fixation and placed in a 7-T magnetic resonance imaging (MRI) scanner...
December 29, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29246240/myocardial-inflammation-injury-and-infarction-during-on-pump-coronary-artery-bypass-graft-surgery
#2
Shirjel R Alam, Colin Stirrat, Nick Spath, Vipin Zamvar, Renzo Pessotto, Marc R Dweck, Colin Moore, Scott Semple, Ahmed El-Medany, Divya Manoharan, Nicholas L Mills, Anoop Shah, Saeed Mirsadraee, David E Newby, Peter A Henriksen
BACKGROUND: Myocardial inflammation and injury occur during coronary artery bypass graft (CABG) surgery. We aimed to characterise these processes during routine CABG surgery to inform the diagnosis of type 5 myocardial infarction. METHODS: We assessed 87 patients with stable coronary artery disease who underwent elective CABG surgery. Myocardial inflammation, injury and infarction were assessed using plasma inflammatory biomarkers, high-sensitivity cardiac troponin I (hs-cTnI) and cardiac magnetic resonance imaging (CMR) using both late gadolinium enhancement (LGE) and ultrasmall superparamagnetic particles of iron oxide (USPIO)...
December 16, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29230805/uspio-labeling-in-m1-and-m2-polarized-macrophages-an-in-vitro-study-using-a-clinical-magnetic-resonance-scanner
#3
Chiara Zini, Mary Anna Venneri, Selenia Miglietta, Damiano Caruso, Natale Porta, Andrea Isidori, Daniela Fiore, Daniele Gianfrilli, Vincenzo Petrozza, Andrea Laghi
BACKGROUND: To evaluate USPIO labeling in different macrophage populations using a clinical 3.0T MR unit with optical and electron microscopy as the gold standard. METHODS: Human monocytic cell line were differentiated into macrophages. Afterwards M0 macrophages were incubated with IL-4 and IL-13 in order to obtain M2 polarized macrophages or with IFN-gamma and LPS for classical macrophage activation (M1). These groups were incubated with USPIO MR contrast agent (P904) for 36 hours; M0, M0+P904, M1+P904 and M2+P904 were analyzed in gel phantoms with a 3...
December 12, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29205621/multiparametric-characterization-of-response-to-anti-angiogenic-therapy-using-uspio-contrast-enhanced-mri-in-combination-with-dynamic-contrast-enhanced-mri
#4
Jana Kim, Eugene Kim, Leslie R Euceda, Dan E Meyer, Karina Langseth, Tone F Bathen, Siver A Moestue, Else Marie Huuse
BACKGROUND: Steady state susceptibility contrast (SSC)-MRI provides information on vascular morphology but is a rarely used method. PURPOSE: To investigate the utility of the ultrasmall superparamagnetic iron oxide particles (USPIOs) GEH121333 for measuring tumor response to bevacizumab and compare this with gadolinium-based DCE-MRI. STUDY TYPE: Prospective preclinical animal model study. ANIMAL MODEL: Mice bearing subcutaneous TOV-21G human ovarian cancer xenografts treated with bevacizumab (n = 9) or saline (n = 9)...
December 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29177411/ultrasmall-superparamagnetic-iron-oxide-imaging-identifies-tissue-and-nerve-inflammation-in-pain-conditions
#5
Shiqian Shen, Weihua Ding, Shihab Ahmed, Ranliang Hu, Arissa Opalacz, Sarah Roth, Zerong You, Gregory R Wotjkiewicz, Grewo Lim, Lucy Chen, Jianren Mao, John W Chen, Yi Zhang
Objective: Correlation between radiologic structural abnormalities and clinical symptoms in low back pain patients is poor. There is an unmet clinical need to image inflammation in pain conditions to aid diagnosis and guide treatment. Ferumoxytol, an ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle, is clinically used to treat iron deficiency anemia and showed promise in imaging tissue inflammation in human. We explored whether ferumoxytol can be used to identify tissue and nerve inflammation in pain conditions in animals and humans...
November 21, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29097941/use-of-ultrasmall-superparamagnetic-iron-oxide-enhanced-susceptibility-weighted-imaging-and-mean-vessel-density-imaging-to-monitor-antiangiogenic-effects-of-sorafenib-on-experimental-hepatocellular-carcinoma
#6
Shuohui Yang, Jiang Lin, Fang Lu, Zhihong Han, Caixia Fu, Hongchen Gu
We investigated effectiveness of ultrasmall superparamagnetic iron oxide enhanced susceptibility weighted imaging (USPIO-enhanced SWI) and mean vessel density imaging (Q) in monitoring antiangiogenic effects of Sorafenib on orthotopic hepatocellular carcinoma (HCC). Thirty-five HCC xenografts were established. USPIO-enhanced SWI and Q were performed on a 1.5 T MR scanner at baseline, 7, 14, and 21 days after Sorafenib treatment. Intratumoral susceptibility signal intensity (ITSS) and Q were serially measured and compared between the treated (n = 15) and control groups (n = 15)...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29064775/uspio-positive-ms-lesions-are-associated-with-greater-tissue-damage-than-gadolinium-positive-only-lesions-during-3-year-follow-up
#7
Anne Kerbrat, Benoit Combès, Olivier Commowick, Adil Maarouf, Elise Bannier, Jean Christophe Ferré, Ayman Tourbah, Jean-Philippe Ranjeva, Christian Barillot, Gilles Edan
BACKGROUND: Identifying in vivo the processes that determine lesion severity in multiple sclerosis (MS) remains a challenge. OBJECTIVES: To describe the dynamics of ultrasmall superparamagnetic iron oxide (USPIO) enhancement in MS lesions and the relationship between USPIO enhancement and microstructural changes over 3 years. METHODS: Lesion development was assessed at baseline, Months 3, 6, and 9, using magnetic resonance imaging (MRI) with gadolinium and USPIO...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29042321/multimodal-imaging-approach-to-examine-biodistribution-kinetics-of-cabotegravir-gsk1265744-long-acting-parenteral-formulation-in-rat
#8
Beat M Jucker, Hasan Alsaid, Mary Rambo, Stephen C Lenhard, Bao Hoang, Fang Xie, M Reid Groseclose, Stephen Castellino, Valeriu Damian, Gary Bowers, Manish Gupta
Long-Acting Parenterals (LAPs) have been used in the clinic to provide sustained therapeutic drug levels at a target site, and thereby reducing the frequency of dosing required. In an effort to understand the factors associated with long-acting cabotegravir (GSK1265744 LAP) pharmacokinetic variability, the current study was designed to investigate the temporal relationship between intramuscular (IM) or subcutaneous (SC) drug depot morphology and distribution kinetics with plasma pharmacokinetics. Therefore, a multi-modal molecular imaging (MRI & MALDI IMS) approach was employed to examine the temporal GSK1265744 LAP biodistribution in rat following either IM or SC administration...
December 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29036827/validation-by-magnetic-resonance-imaging-of-the-diagnostic-potential-of-a-heptapeptide-functionalized-imaging-probe-targeted-to-amyloid-%C3%AE-and-able-to-cross-the-blood-brain-barrier
#9
Séverine André, Emilie Ansciaux, Elamine Saidi, Lionel Larbanoix, Dimitri Stanicki, Denis Nonclercq, Luce Vander Elst, Sophie Laurent, Robert N Muller, Carmen Burtea
The diagnosis of Alzheimer's disease (AD) is a critical step in the management of patients. We have developed a non-invasive diagnosis tool based on magnetic resonance molecular imaging (MRMI) of amyloid-β peptide using ultra-small particles of iron oxide (USPIO) functionalized with a disulfide constrained cyclic heptapeptide (PHO) identified by phage display (USPIO-PHO). After previously demonstrating the optimal pharmacologic properties of USPIO-PHO and its capacity to cross the blood-brain barrier (BBB), the ability of USPIO-PHO to target amyloid plaques (AP) by MRMI has been validated in the present work on AD transgenic mice...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28986753/toward-a-new-and-noninvasive-diagnostic-method-of-papillary-thyroid-cancer-by-using-peptide-vectorized-contrast-agents-targeted-to-galectin-1
#10
Deborah Fanfone, Nadège Despretz, Dimitri Stanicki, Jenifer Rubio-Magnieto, Mathieu Fossépré, Mathieu Surin, Sandrine Rorive, Isabelle Salmon, Luce Vander Elst, Sophie Laurent, Robert N Muller, Sven Saussez, Carmen Burtea
The incidence of papillary thyroid cancer has increased these last decades due to a better detection. High prevalence of nodules combined with the low incidence of thyroid cancers constitutes an important diagnostic challenge. We propose to develop an alternative diagnostic method to reduce the number of useless and painful thyroidectomies using a vectorized contrast agent for magnetic resonance imaging. Galectin-1 (gal-1), a protein overexpressed in well-differentiated thyroid cancer, has been targeted with a randomized linear 12-mer peptide library using the phage display technique...
October 6, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28986407/ferumoxytol-enhanced-magnetic-resonance-imaging-in-acute-myocarditis
#11
Colin G Stirrat, Shirjel R Alam, Thomas J MacGillivray, Calum D Gray, Marc R Dweck, Kevin Dibb, Nick Spath, John R Payne, Sanjay K Prasad, Roy S Gardner, Saeed Mirsadraee, Peter A Henriksen, Scott Ik Semple, David E Newby
OBJECTIVES: Ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced MRI can detect tissue-resident macrophage activity and identify cellular inflammation within tissues. We hypothesised that USPIO-enhanced MRI would provide a non-invasive imaging technique that would improve the diagnosis and management of patients with acute myocarditis. METHODS: Ten volunteers and 14 patients with suspected acute myocarditis underwent T2, T2* and late gadolinium enhancement (LGE) 3T MRI, with further T2* imaging at 24 hours after USPIO (ferumoxytol, 4 mg/kg) infusion, at baseline and 3 months...
October 6, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28956266/magnetic-resonance-imaging-of-tumor-angiogenesis-using-dual-targeting-rgd10-ngr9-ultrasmall-superparamagnetic-iron-oxide-nanoparticles
#12
T Wu, X Ding, B Su, A K Soodeen-Lalloo, L Zhang, J-Y Shi
OBJECTIVE: Using RGD10-NGR9 dual-targeting superparamagnetic iron oxide nanoparticles to evaluate their potential value in tumor angiogenesis magnetic resonance imaging (MRI) and the biodistribution in vitro and in vivo. MATERIALS AND METHODS: Dual-targeting RGD10-NGR9 ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles were designed and synthesized in our previous study. In vitro, prussian blue staining and phenanthroline colorimetry were conducted to evaluate binding affinity and adsorption of dual-targeting USPIO nanoparticles to αvβ3-integrin/APN positive cells...
September 27, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28808955/exploring-the-biological-and-mechanical-properties-of-abdominal-aortic-aneurysms-using-uspio-mri-and-peak-tissue-stress-a-combined-clinical-and-finite-element-study
#13
Noel Conlisk, Rachael O Forsythe, Lyam Hollis, Barry J Doyle, Olivia M B McBride, Jennifer M J Robson, Chengjia Wang, Calum D Gray, Scott I K Semple, Tom MacGillivray, Edwin J R van Beek, David E Newby, Peter R Hoskins
Inflammation detected through the uptake of ultrasmall superparamagnetic particles of iron oxide (USPIO) on magnetic resonance imaging (MRI) and finite element (FE) modelling of tissue stress both hold potential in the assessment of abdominal aortic aneurysm (AAA) rupture risk. This study aimed to examine the spatial relationship between these two biomarkers. Patients (n = 50) > 40 years with AAA maximum diameters > = 40 mm underwent USPIO-enhanced MRI and computed tomography angiogram (CTA). USPIO uptake was compared with wall stress predictions from CTA-based patient-specific FE models of each aneurysm...
August 14, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28782610/anti-connective-tissue-growth-factor-detects-and-reduces-plaque-inflammation-in-early-stage-carotid-atherosclerotic-lesions
#14
Yuyu Yao, Bing Li, Cong Fu, Gaojun Teng, Genshan Ma, Naifeng Liu
This study explored connective tissue growth factor (CTGF)-targeted ultrasmall superparamagnetic iron oxides (USPIOs) for noninvasive MRI of CTGF within carotid atherosclerotic lesions in apoE-deficient (apoE(-/-)) mice. Anti-CTGF polyclonal and nonspecific IgG antibodies were conjugated to polyethylene glycol-coated USPIOs, and apoE(-/-) carotid partial ligation-model mice were imaged via MRI before and after contrast administration. ApoE(-/-) mice were treated with CTGF-neutralizing antibodies for 3 weeks...
August 3, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28720724/aortic-wall-inflammation-predicts-abdominal-aortic-aneurysm-expansion-rupture-and-need-for-surgical-repair
#15
(no author information available yet)
BACKGROUND: Ultrasmall superparamagnetic particles of iron oxide (USPIO) detect cellular inflammation on magnetic resonance imaging (MRI). In patients with abdominal aortic aneurysm, we assessed whether USPIO-enhanced MRI can predict aneurysm growth rates and clinical outcomes. METHODS: In a prospective multicenter open-label cohort study, 342 patients with abdominal aortic aneurysm (diameter ≥40 mm) were classified by the presence of USPIO enhancement and were monitored with serial ultrasound and clinical follow-up for ≥2 years...
August 29, 2017: Circulation
https://www.readbyqxmd.com/read/28662398/evaluation-of-ultrasmall-superparamagnetic-iron-oxide-uspio-enhanced-mri-with-ferumoxytol-to-quantify-arterial-wall-inflammation
#16
Loek P Smits, Feiko Tiessens, Kang He Zheng, Erik S Stroes, Aart J Nederveen, Bram F Coolen
BACKGROUND AND AIMS: Inflammation in atherosclerotic plaques is an important determinant of plaque vulnerability, and can be detected non-invasively using ultra-small superparamagnetic iron-oxide (USPIO) enhanced MRI. The aims of the current study were: 1) to determine whether ferumoxytol can be used for USPIO-MRI of atherosclerotic plaques, 2) to establish a protocol for quantitative USPIO-MRI of carotid artery plaques using ferumoxytol, and 3) to study the relation between USPIO uptake and plaque burden and (18)F-fluorodeoxyglucose (FDG) uptake (measured by (18)F-FDG PET/CT scan) in atherosclerotic plaques...
June 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28642288/ferumoxytol-enhanced-magnetic-resonance-imaging-assessing-inflammation-after-myocardial-infarction
#17
Colin G Stirrat, Shirjel R Alam, Thomas J MacGillivray, Calum D Gray, Marc R Dweck, Jennifer Raftis, William Sa Jenkins, William A Wallace, Renzo Pessotto, Kelvin Hh Lim, Saeed Mirsadraee, Peter A Henriksen, Scott Ik Semple, David E Newby
OBJECTIVES: Macrophages play a central role in the cellular inflammatory response to myocardial infarction (MI) and predict subsequent clinical outcomes. We aimed to assess temporal changes in cellular inflammation and tissue oedema in patients with acute MI using ultrasmallsuperparamagnetic particles of iron oxide (USPIO)-enhanced MRI. METHODS: Thirty-one patients were recruited following acute MI and followed up for 3 months with repeated T2 and USPIO-enhanced T2*-mapping MRI...
October 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28627754/labeling-and-magnetic-resonance-imaging-of-exosomes-isolated-from-adipose-stem-cells
#18
Alice Busato, Roberta Bonafede, Pietro Bontempi, Ilaria Scambi, Lorenzo Schiaffino, Donatella Benati, Manuela Malatesta, Andrea Sbarbati, Pasquina Marzola, Raffaella Mariotti
Adipose stem cells (ASC) represent a promising therapeutic approach for neurodegenerative diseases. Most biological effects of ASC are probably mediated by extracellular vesicles, such as exosomes, which influence the surrounding cells. Current development of exosome therapies requires efficient and noninvasive methods to localize, monitor, and track the exosomes. Among imaging methods used for this purpose, magnetic resonance imaging (MRI) has advantages: high spatial resolution, rapid in vivo acquisition, and radiation-free operation...
June 19, 2017: Current Protocols in Cell Biology
https://www.readbyqxmd.com/read/28463893/imaging-pathobiology-of-carotid-atherosclerosis-with-ultrasmall-superparamagnetic-particles-of-iron-oxide-an-update
#19
Umar Sadat, Ammara Usman, Jonathan H Gillard
PURPOSE OF REVIEW: To provide brief overview of the developments regarding use of ultrasmall superparamagnetic particles of iron oxide in imaging pathobiology of carotid atherosclerosis. RECENT FINDINGS: MRI is a promising technique capable of providing morphological and functional information about atheromatous plaques. MRI using iron oxide particles, called ultrasmall superparamagnetic iron oxide (USPIO) particles, allows detection of macrophages in atherosclerotic tissue...
July 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28462154/an-explanatory-case-on-the-limitations-of-lymph-node-staging-in-recurrent-prostate-cancer
#20
Marco Bandini, Giorgio Gandaglia, Nicola Fossati, Francesco Montorsi, Alberto Briganti
We describe the case of a 54-year-old man with nodal recurrence prostate cancer after radical prostatectomy, salvage external-beam radiotherapy and salvage lymph node dissection. The patient was evaluated with a lymphotropic ultrasmall superparamagnetic particles of iron oxide (USPIO)-MRI and a (68)Ga radiolabelled prostate specific membrane antigen (Ga68-PSMA) PET-CT scan which enhanced persistent localized nodal disease. The patient was then considered for a second robot-assisted extended S-LND. Differently from preoperative imaging, pathology report revealed a wide nodal involvement mirroring a metastatic disease...
May 2017: Urology Case Reports
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