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https://www.readbyqxmd.com/read/29346790/multivisceral-resection-for-locally-invasive-colorectal-liver-metastases-outcomes-of-a-matched-cohort-analysis
#1
Fiona Hand, Rebeca Sanabria Mateos, Michael Durand, David Fennelly, Ray McDermott, Donal Maguire, Justin Geoghegan, Des Winter, Emir Hoti
Local invasion of adjacent viscera by colorectal liver metastases (CRLM) is no longer considered an absolute contraindication to curative hepatic resection. A growing number of observational analyses have illustrated the feasibility of such resections; however, the evidence base is at best heterogeneous with a lack of evidence comparing similar patient groups. We aimed to evaluate the outcomes of hepatectomy for CRLM when combined with other viscera and compare to a matched cohort of isolated hepatic resections...
January 18, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29346782/a-fair-chance-for-everyone-total-tumor-volume-as-a-selection-tool-in-liver-transplantation-for-hepatocellular-carcinoma
#2
Hugo Pinto-Marques, Silvia Silva, Mafalda Sobral, Rui Perdigoto, Américo Martins, Eduardo Barroso
Total tumor volume (TTV) has been proposed as a more accurate means of selecting patients for liver transplantation (LT) due to hepatocellular carcinoma (HCC). We aim to analyze the role of TTV in a population with a short waiting time on list. METHODS: Analysis of a prospective database of patients submitted to LT for HCC between September 1992 and February 2014. TTV, Milan criteria (MC), UCSF (University of California San Francisco), and "Up to Seven" criteria were calculated both with preoperative imaging exams and histological data...
January 18, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29346131/toxicological-profile-and-safety-pharmacology-of-a-single-dose-of-fibroblast-activation-protein-%C3%AE-based-doxorubicin-prodrug-in-vitro-and-in-vivo-evaluation
#3
Sichao Huang, Yuchen Zhang, Jinsong Zhong, Ying Pan, Shaohui Cai, Jun Xu
Fibroblast activation protein-α (FAPα) is a promising tumor-associated target expressed by reactive stromal fibroblasts in tumor tissue. FAPα has a postprolyl peptidase activity and can specifically cleave N-terminal benzyloxycarbonyl (Z)-blocked peptides, such as the substrate Z-Gly-Pro-AMC. Doxorubicin (DOX) is an effective antitumor drug, but its application is greatly limited by toxic adverse effects owing to poor tumor selectivity. Based on these facts, we previously designed a FAPα-targeting prodrug of doxorubicin (FTPD) which can be selectively hydrolyzed by FAPα...
January 17, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29346078/long-term-high-air-pollution-exposure-induced-metabolic-adaptations-in-traffic-policemen
#4
Chaochao Tan, Yupeng Wang, Mingyue Lin, Zhu Wang, Li He, Zhiyi Li, Yu Li, Keqian Xu
OBJECTIVE: To assess the adverse physiological changes induced by long-term exposure to PM2.5. METHODS: Totally 183 traffic policemen and 88 office policemen as the control group, were enrolled in this study. The concentrations of PM2.5 in both the working places of traffic and office policemen were obtained. Detailed personal questionnaires and conventional laboratory tests including hematology, fasting blood glucose, blood lipids, liver, kidney, immunity and tumor-related markers were conducted on all participants of this study...
January 5, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29345041/serum-amyloid-a-procalcitonin-highly-sensitive-c-reactive-protein-and-tumor-necrosis-factor-alpha-levels-and-acute-inflammatory-response-in-patients-with-hemolysis-elevated-liver-enzymes-low-platelet-count-hellp-and-eclampsia
#5
Kazım Uckan, Hanım Guler Sahin
AIM: The aim of this study was to determine the relationship between serum amyloid A (SAA), procalcitonin (ProC), highly sensitive C reactive protein (hsCRP) and tumor necrosis factor (TNF) alpha activity in patients with pre-eclampsia, eclampsia and hemolysis, elevated liver enzymes, low platelet count (HELLP), and the pathogenesis and severity of the disease. METHOD: Ninety patients at ≥ 32 gestational weeks, according to the last date of menstruation and ultra-sonographic measurements, diagnosed with pre-eclampsia (30 patients), eclampsia (30 patients) or HELLP syndrome (30 patients) were included in the study...
January 18, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29344901/imaging-characteristics-and-first-experience-of-68ga-thp-psma-a-novel-probe-for-rapid-kit-based-ga-68-labeling-and-pet-imaging-comparative-analysis-with-68ga-psma-i-t
#6
Thorsten Derlin, Sebastian Schmuck, Cathleen Juhl, Steffi Teichert, Johanna Zörgiebel, Hans-Jürgen Wester, Sophie M Schneefeld, Almut C A Walte, James T Thackeray, Tobias L Ross, Frank M Bengel
PURPOSE: [68Ga]Trishydroxypyridinone (THP)-prostate-specific membrane antigen (PSMA) is a novel tracer that can be labeled in one step by cold reconstitution of a kit with unprocessed generator eluate, targeting PSMA via the lysine-urea-glutamate (KuE) motif. The aim of this study was to evaluate the human imaging characteristics of [68Ga]THP-PSMA. PROCEDURES: [68Ga]THP-PSMA positron emission tomography (PET)/x-ray computed tomography (CT) was performed in 25 patients with biochemical recurrence after radical prostatectomy for prostate cancer...
January 17, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29344744/interleukin-1-receptor-antagonist-inhibits-angiogenesis-in-gastric-cancer
#7
Zhenqiang Gong, Jiachi Ma, He Su, Tiankang Guo, Hui Cai, Quan Chen, Xiaodan Zhao, Jianbo Qi, Jianbo Du
BACKGROUND: Interleukin-1 alpha (IL-1α) plays an important role in tumorigenesis and angiogenesis of gastric cancer. The interleukin-1 receptor antagonist (IL-1RA) inhibits IL-1 selectively and specifically through IL-1R type I (IL-1RI). However, the underlying mechanism by which IL-1RA modulates the interactions of tumor cells and their micro-environment is poorly understood. We have evaluated the role of IL-1RA in the metastatic process as well as the mutual or reciprocal actions between gastric cancer cells and stromal cells...
January 17, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29344672/histone-deacetylase-inhibitor-trichostatin-a-and-autophagy-inhibitor-chloroquine-synergistically-exert-anti-tumor-activity-in-h-ras-transformed-breast-epithelial-cells
#8
Liang Gao, Xin Sun, Qi Zhang, Xiaochen Chen, Tongwei Zhao, Liqing Lu, Jianbin Zhang, Yupeng Hong
Histone deacetylase inhibitors (HDACIs) cause oncogene‑transformed mammalian cell death. Our previous study indicated that HDACIs activate forkhead box O1 (FOXO1) and induce autophagy in liver and colon cancer cells. However, whether FOXO1 is involved in HDACI‑mediated oncogene‑transformed mammalian cell death remains unclear. In the present study, H‑ras transformed MCF10A cells were used to investigate the role of FOXO1 in this pathway. Results showed that trichostatin A (TSA), a HDACI, activated apoptosis in MCF10A‑ras cells, but not in MCF10A cells...
January 17, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29344642/microarray-analysis-reveals-tmub1-as-a-cell-cycle-associated-protein-in-rat-hepatocytes
#9
Hangwei Fu, Jianhua Xu, Jian Chen, Guangyao Li, Xiaobiao Zhao, Ping Chen
Transmembrane and ubiquitin-like domain containing protein 1 (Tmub1), formerly known as hepatocyte odd protein shuttling (HOPS) has been recognized as a ubiquitously expressed shuttling protein that moves between the nucleus and cytoplasm in hepatocytes. Tmub1 is involved in liver regeneration and functions as a bridging protein in tumor cell proliferation. To investigate the transcriptional profile and potential biological processes affected by Tmub1 expression in normal rat hepatocytes, microarray and bioinformatics experiments were used to identify 127 mRNAs differentially expressed between Tmub1‑overexpression, Tmub1‑knockdown and normal BRL‑3A cells (fold‑change ≥2...
January 17, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29344517/a-comparison-of-pitfalls-after-alpps-stage-1-or-portal-vein-embolization-in-small-for-size-setting-hepatectomies
#10
REVIEW
Andreas A Schnitzbauer
Background: Portal vein embolization (PVE) followed by resection and associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) are tools to enable liver resections in small-for-size settings. Methods: A systematic review of the literature and comparison of pitfalls between PVE and resection and after ALPPS stage 1 were performed. Results: Evidence levels were as low as 4 for both procedures. 20 publications were identified with reports on post-PVE or post-ALPPS stage 1 pitfalls...
December 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29344513/-in-situ-split-liver-resection-alpps-historical-development-and-current-practice
#11
REVIEW
Hans J Schlitt, Christina Hackl, Sven Arke Lang
Background: Liver tumors that are extensive, multifocal, or critically located frequently require advanced techniques of liver resection including '!' - enabling liver resection in certain situations. Methods: The development of the technique in the first and the subsequent 8 patients in the index center, and also the method's spread throughout Germany and the world were reviewed. Results: In 2007, in the first patient, the new technique was developed intraoperatively by necessity...
December 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29344478/incidentally-discovered-adenoid-cystic-carcinoma-of-the-lacrimal-gland-with-isolated-liver-metastases
#12
Robi N Maamari, Philip L Custer, George J Harocopos
Aim: To report a rare presentation of adenoid cystic carcinoma (ACC) of the lacrimal gland. Method: This is a case report presenting clinical, radiographic, and histopathologic findings. Results: A 72-year-old female with no reported ocular symptoms was found to have an incidental right orbital mass on imaging. Additional studies revealed multiple liver lesions, which were biopsied and found to be consistent with ACC. She was then referred to the ophthalmology service, where ocular examination demonstrated 2...
November 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344353/effects-of-tnf-receptor-blockade-on-in-vitro-cell-survival-and-response-to-negative-energy-balance-in-dairy-cattle
#13
C A Martel, L K Mamedova, J E Minton, M Garcia, C Legallet, B J Bradford
Background: Associative data and some controlled studies suggest that the inflammatory cytokine tumor necrosis factor (TNF) α can induce fatty liver in dairy cattle. However, research demonstrating that TNFα is a necessary component in the etiology of bovine fatty liver is lacking. The aim of this work was to evaluate whether blocking TNFα signaling with a synthetic cyclic peptide (TNF receptor loop peptide; TRLP) would improve liver metabolic function and reduce triglyceride accumulation during feed restriction...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29344306/131i-labeled-copper-sulfide-loaded-microspheres-to-treat-hepatic-tumors-via-hepatic-artery-embolization
#14
Qiufang Liu, Yuyi Qian, Panli Li, Sihang Zhang, Jianjun Liu, Xiaoguang Sun, Michael Fulham, Dagan Feng, Gang Huang, Wei Lu, Shaoli Song
Purpose: Transcatheter hepatic artery embolization therapy is a minimally invasive alternative for treating inoperable liver cancer but recurrence is frequent. Multifunctional agents, however, offer an opportunity for tumor eradication. In this study, we were aim to synthesized poly (lactic-co-glycolic acid) (PLGA) microspheres encapsulating hollow CuS nanoparticles (HCuSNPs) and paclitaxel (PTX) that were then labeled with radioiodine-131 (131I) to produce 131I-HCuSNPs-MS-PTX. This compound combines the multi-theranostic properties of chemotherapy, radiotherapy and photothermal therapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29344299/enhanced-synergism-of-thermo-chemotherapy-for-liver-cancer-with-magnetothermally-responsive-nanocarriers
#15
Minghua Li, Wenbo Bu, Jie Ren, Jianbo Li, Li Deng, Mingyuan Gao, Xiaolong Gao, Peijun Wang
A combination of magnetic hyperthermia and magnetothermally-facilitated drug release system was developed as a promising strategy for liver cancer therapy. The thermosensitive copolymer, 6sPCL-b-P(MEO2MA-co-OEGMA) shows a good temperature-controlled drug release response. Mn-Zn ferrite magnetic nanoparticles (MZF-MNPs) exhibit a strong magnetic thermal effect with an alternating magnetic field (AMF). Owing to its high magnetic sensitivity, the magnetothermally-responsive nanocarrier/doxorubicin (MTRN/DOX) can be concentrated in the tumor site efficiently through magnetic targeting...
2018: Theranostics
https://www.readbyqxmd.com/read/29344254/inhibitory-effect-of-the-low-toxic-exogenous-aryl-hydrocarbon-receptor-modulator-3-3-diindolylmethane-on-gastric-cancer-in-mice
#16
Mingli Su, Chenchen Qian, Yumin Hu, Wenhua Lu, Rongkang Huang, Minhu Chen, Jie Chen
3'3-Diindolylmethane (DIM) has been proved to exhibit anticancer properties in many solid tumors. In our previous study, we demonstrated that DIM inhibited SGC7901 cell proliferation by inducing apoptosis and delaying cell cycle progression. Herein, we further explored the anti-tumor effect of DIM on SGC-7901 tumor bearing mice. Tumors were excised, weighed, and tested by western blot and TdT-UTP nick-end labeling (TUNEL) assay. Blood samples were collected for biochemical analysis. The expression levels of AhR and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) protein were evaluated by western-blot assay...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344248/survival-prediction-in-patients-with-resectable-colorectal-liver-metastases-clinical-risk-scores-and-tumor-response-to-chemotherapy
#17
Da Xu, Xiao-Feng Liu, Xiao-Luan Yan, Kun Wang, Bao-Cai Xing
Clinical risk scores and response to pre-operative chemotherapy are prognostic factors of colorectal liver metastases. The aim of the present study was to evaluate the effectiveness of combining these factors to predict patient survival and to select patients for curative therapy. The study included 189 patients who underwent hepatectomy following neo-adjuvant chemotherapy, for initially resectable colorectal liver metastases, between January 2005 and December 2015. Patients were stratified into four sub-groups: A1-2, low clinical risk scores with/without a response to pre-operative chemotherapy; and B1-2, high clinical risk scores with or without a response to pre-operative chemotherapy...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344209/the-effect-of-royal-jelly-on-the-growth-of-breast-cancer-in-mice
#18
Shuang Zhang, Qiqi Shao, Haiyang Geng, Songkun Su
Due to various pharmacological properties, including antioxidative, anti-inflammatory and antibiotic properties, royal jelly (RJ) has been widely consumed in daily diets in numerous countries. In the present study, the effect of RJ on 4T1-bearing mice was investigated. The study was performed by feeding 4T1-bearing mice with RJ using either the prophylactic-therapeutic (PTRJ) or therapeutic (TRJ) method. The experimental results for the PTRJ group demonstrated that the weight of tumor was significantly reduced (RJ 0...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344201/elevation-of-serum-cea-and-ca15-3-levels-during-antitumor-therapy-predicts-poor-therapeutic-response-in-advanced-breast-cancer-patients
#19
Yue Yang, Huijuan Zhang, Mingyan Zhang, Qingwei Meng, Li Cai, Qingyuan Zhang
The aim of the present study was to assess the correlation between therapeutic response and carcinoembryonic antigen (CEA) and carbohydrate antigen 15-3 (CA15-3) levels in advanced breast cancer patients with non-assessable lesions or stable disease (SD) according to the Response Evaluation Criteria in Solid Tumors. A total of 232 female patients with recurrent tumors following radical mastectomy were recruited, including 76 patients with non-assessable lesions and 60 patients with SD. The correlation between CEA and CA15-3 changes, progression-free survival (PFS) and therapeutic response were analyzed in the non-assessable and SD patient groups...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344189/phosphorylated-akt-expression-in-tumor-adjacent-normal-tissue-is-associated-with-poor-prognosis-in-patients-with-hepatocellular-carcinoma
#20
Yao-Li Chen, Po-Ming Chen, Ying-Zi Ming, Ping-Yi Lin, Chih-Ping Chu, Pei-Yi Chu
The AKT pathway serves important roles in tumor cell growth. Its overexpression is associated with poor prognosis in a number of types of cancer; however, the role of AKT in the role of the pathogenesis of hepatocellular carcinoma (HCC) remains unclear. The present study was undertaken to explore the clinical relevance of phosphorylated AKT (p-AKT) in HCC. The level of p-AKT in tumor (TU) and paired adjacent normal liver (AN) tissue from 202 HCC patients was evaluated with immunohistochemistry. The results demonstrated that p-AKT was more highly expressed in TU than in AN tissue...
December 2017: Oncology Letters
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