keyword
https://read.qxmd.com/read/38537130/comprehensive-molecular-classification-predicted-microenvironment-profiles-and-therapy-response-for-hepatocellular-carcinoma
#1
JOURNAL ARTICLE
Yihong Chen, Xiangying Deng, Yin Li, Ying Han, Yinghui Peng, Wantao Wu, Xinwen Wang, Jiayao Ma, Erya Hu, Xin Zhou, Edward Shen, Shan Zeng, Changjing Cai, Yiming Qin, Hong Shen
BACKGROUND AND AIMS: Tumor microenvironment (TME) heterogeneity leads to a discrepancy in survival prognosis and clinical treatment response for hepatocellular carcinoma (HCC) patients. The clinical applications of documented molecular subtypes are constrained by several issues. APPROACH AND RESULTS: We integrated three single-cell datasets to describe the TME landscape and identified six prognosis-related cell subclusters. Unsupervised clustering of subcluster-specific markers was performed to generate transcriptomic subtypes...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38536862/ultrastable-iodinated-oil-based-pickering-emulsion-enables-locoregional-sustained-codelivery-of-hypoxia-inducible-factor-1-inhibitor-and-anticancer-drugs-for-tumor-combination-chemotherapy
#2
JOURNAL ARTICLE
Zhihua Li, Xiaoya Liu, Jingyu Xiao, Hang Jiang, Le Ma, Yucheng Luo, Meijuan Wang, Yuwei Zhu, Hongliang Jiang, Hanyang Yao, To Ngai, Qiongyu Guo
Tumor hypoxia-associated drug resistance presents a major challenge for cancer chemotherapy. However, sustained delivery systems with a high loading capability of hypoxia-inducible factor-1 (HIF-1) inhibitors are still limited. Here, we developed an ultrastable iodinated oil-based Pickering emulsion (PE) to achieve locally sustained codelivery of a HIF-1 inhibitor of acriflavine and an anticancer drug of doxorubicin for tumor synergistic chemotherapy. The PE exhibited facile injectability for intratumoral administration, great radiopacity for in vivo examination, excellent physical stability (>1 mo), and long-term sustained release capability of both hydrophilic drugs (i...
March 27, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38536498/effect-of-vitamin-d3-supplementation-on-blood-parameters-and-liver-gene-expression-in-female-rats
#3
JOURNAL ARTICLE
Maria Oczkowicz, Beata Szymczyk, Małgorzata Świątkiewicz, Alicja Wierzbicka, Anna Steg, Tomasz Szmatoła
BACKGROUND: To better understand the molecular mechanism responsible for the therapeutic potential of vitamin D, we conducted an analysis of the liver transcriptomes of adult female rats. METHODS: Adult female rats (n = 18) were divided into three groups, receiving different doses of vitamin D: group I, 0; group II, 1000 U/kg; and group III, 5000 U/kg. Growth, body weight, the weight of main organs, blood haematological and biochemical parameters were evaluated...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536464/automated-graded-prognostic-assessment-for-patients-with-hepatocellular-carcinoma-using-machine-learning
#4
JOURNAL ARTICLE
Moritz Gross, Stefan P Haider, Tal Ze'evi, Steffen Huber, Sandeep Arora, Ahmet S Kucukkaya, Simon Iseke, Bernhard Gebauer, Florian Fleckenstein, Marc Dewey, Ariel Jaffe, Mario Strazzabosco, Julius Chapiro, John A Onofrey
BACKGROUND: Accurate mortality risk quantification is crucial for the management of hepatocellular carcinoma (HCC); however, most scoring systems are subjective. PURPOSE: To develop and independently validate a machine learning mortality risk quantification method for HCC patients using standard-of-care clinical data and liver radiomics on baseline magnetic resonance imaging (MRI). METHODS: This retrospective study included all patients with multiphasic contrast-enhanced MRI at the time of diagnosis treated at our institution...
March 27, 2024: European Radiology
https://read.qxmd.com/read/38535244/toxicity-assessment-of-new-ag-zno-ago-nanocomposites-an-in-vitro-and-in-vivo-approach
#5
JOURNAL ARTICLE
José Rodrigues do Carmo Neto, Pablo Igor Ribeiro Franco, Yarlla Loyane Lira Braga, Jordana Fernandes de Oliveira, Hugo Felix Perini, Luís Fernando Duarte Albuquerque, Danieli Brolo Martins, Fernanda Rodrigues Helmo, Anderson Assunção Andrade, Marina Pacheco Miguel, Mara Rúbia Nunes Celes, Thiago Lopes Rocha, Anielle Christine Almeida Silva, Juliana Reis Machado, Marcos Vinícius da Silva
Zinc oxide nanoparticles (ZnO NPs) are metal oxide nanomaterials, which are important for several applications: antibacterial, anthelmintic, antiprotozoal and antitumoral, among others. These applications are mainly related to the ability to spontaneously produce and induce the production of reactive oxygen species that are important components for the destruction of pathogens and tumor cells. While trying to potentiate ZnO NPs, studies have associated these NPs with silver oxide (AgO) or silver (Ag) NPs. It has already been reported that this combination (Ag-ZnO/AgO NPs) is able to enhance the microbicidal potential...
February 20, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38534987/targeting-solute-carrier-transporters-slcs-as-a-therapeutic-target-in-different-cancers
#6
REVIEW
Ravi Bharadwaj, Swati Jaiswal, Erandi E Velarde de la Cruz, Ritesh P Thakare
Solute carrier (SLC) transporters constitute a vast superfamily of transmembrane proteins tasked with regulating the transport of various substances such as metabolites, nutrients, ions, and drugs across cellular membranes. SLC transporters exhibit coordinated expression patterns across normal tissues, suggesting a tightly regulated regulatory network governing normal cellular functions. These transporters are crucial for the transport of various metabolites, including carbohydrates, proteins, lipids, and nucleic acids...
March 21, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534516/the-humanization-and-maturation-of-an-anti-prpc-antibody
#7
JOURNAL ARTICLE
Cheng Zhang, Fanlei Ran, Lei Du, Xiaohui Wang, Lei Liu, Jinming Liu, Quan Chen, Yang Cao, Lijun Bi, Haiying Hang
The cellular prion protein (PrPc) is a cell surface glycoprotein that is highly expressed in a variety of cancer tissues in addition to the nervous system, and its elevated expression is correlated to poor prognosis in many cancer patients. Our team previously found that patients with colorectal cancer (CRC) with high-level PrPc expression had significantly poorer survival than those with no or low-level PrPc expression. Mouse antibodies for PrPc inhibited tumor initiation and liver metastasis of PrPc-positive human CRC cells in mouse model experiments...
February 29, 2024: Bioengineering
https://read.qxmd.com/read/38534501/improving-generalizability-of-pet-dl-algorithms-list-mode-reconstructions-improve-dotatate-pet-hepatic-lesion-detection-performance
#8
JOURNAL ARTICLE
Xinyi Yang, Michael Silosky, Jonathan Wehrend, Daniel V Litwiller, Muthiah Nachiappan, Scott D Metzler, Debashis Ghosh, Fuyong Xing, Bennett B Chin
Deep learning (DL) algorithms used for DOTATATE PET lesion detection typically require large, well-annotated training datasets. These are difficult to obtain due to low incidence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and the high cost of manual annotation. Furthermore, networks trained and tested with data acquired from site specific PET/CT instrumentation, acquisition and processing protocols have reduced performance when tested with offsite data. This lack of generalizability requires even larger, more diverse training datasets...
February 27, 2024: Bioengineering
https://read.qxmd.com/read/38533761/the-influence-of-microwave-ablation-parameters-on-the-positioning-of-trocar-in-different-cancerous-tissues-a-numerical-study
#9
JOURNAL ARTICLE
Vellavalapalli Satish, Ramjee Repaka
The present study analyzed the microwave ablation of cancerous tumors located in six major cancer-prone organs and estimated the significance of input power and treatment time parameters in the apt positioning of the trocar into the tissue during microwave ablation. The present study has considered a three-dimensional two-compartment tumour-embedded tissue model. FEA based COMSOL Multiphysics software with inbuilt bioheat transfer, electromagnetic waves, heat transfer in solids and fluids, and laminar flow physics has been used to obtain the numerical results...
March 27, 2024: Electromagnetic Biology and Medicine
https://read.qxmd.com/read/38533380/clinical-efficacy-of-probiotics-in-the-treatment-of-alcoholic-liver-disease-a-systematic-review-and-meta-analysis
#10
Shi-Ying Xiong, Gui-Sheng Wu, Chun Li, Wenzhe Ma, Huai-Rong Luo
OBJECTIVE: Alcoholic liver disease (ALD) is a liver damage disease caused by long-term heavy drinking. Currently, there is no targeted pharmaceutical intervention available for the treatment of this disease. To address this, this paper evaluates the efficacy and safety of probiotic preparation in treating ALD through conducting a meta-analysis, and provides a valuable insight for clinical decision-making. METHODS: A systematic search was conducted across databases, including PubMed, Embase, Web of Science, Cochrane Library, CNKI, VIP, Wanfang, and CBM from the inception dates to October 15, 2023, to identify clinical randomized controlled trials on probiotic preparations in the treatment of ALD...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38533361/effects-of-secukinumab-combined-with-tretinoin-on-metabolism-liver-enzymes-and-inflammatory-factors-in-patients-with-moderate-to-severe-psoriasis-vulgaris
#11
JOURNAL ARTICLE
Yong Chen, Mei Yi, Xiaoyan Pang, Mengfei Du, Haizhou Chen, Zhenshu Li
INTRODUCTION: Psoriasis is a T cell-mediated polygenic chronic inflammatory disease. Interleukin (IL)-17A plays a major role in psoriasis pathogenesis. Secukinumab is a high-affinity human monoclonal antibody against IL-17A. AIM: This article explored efficacy and safety of secukinumab plus tretinoin in moderate to severe psoriasis (MSP) vulgaris, and assessed metabolism, liver function, and inflammation. MATERIAL AND METHODS: A total of 135 patients diagnosed with moderate or severe psoriasis vulgaris were enrolled and randomized into three groups at a 1 : 1 : 1 ratio, receiving treatment with rretinoin, secukinumab, or combination therapy for a duration of 16 weeks...
February 2024: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38533053/il-22-promotes-liver-regeneration-after-portal-vein-ligation
#12
JOURNAL ARTICLE
Tao Zhang, Philipp Seeger, Yashin Simsek, Morsal Sabihi, Jöran Lücke, Dimitra E Zazara, Ahmad Mustafa Shiri, Jan Kempski, Tom Blankenburg, Lilan Zhao, Ioannis Belios, Andres Machicote, Baris Mercanoglu, Mohammad Fard-Aghaie, Sara Notz, Panagis M Lykoudis, Marius Kemper, Tarik Ghadban, Oliver Mann, Thilo Hackert, Jakob R Izbicki, Thomas Renné, Samuel Huber, Anastasios D Giannou, Jun Li
BACKGROUND: Insufficient remnant liver volume (RLV) after the resection of hepatic malignancy could lead to liver failure and mortality. Portal vein ligation (PVL) prior to hepatectomy is subsequently introduced to increase the remnant liver volume and improve the outcome of hepatic malignancy. IL-22 has previously been reported to promote liver regeneration, while facilitating tumor development in the liver via Steap4 upregulation. Here we performed PVL in mouse models to study the role of IL-22 in liver regeneration post-PVL...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532338/carbon-ion-radiotherapy-for-hepatocellular-carcinoma-with-major-vascular-invasion-a-retrospective-cohort-study
#13
JOURNAL ARTICLE
Takashi Kaneko, Hirokazu Makishima, Masaru Wakatsuki, Yuichi Hiroshima, Toshiaki Matsui, Shigeo Yasuda, Naomi Nagatake Okada, Kenji Nemoto, Hiroshi Tsuji, Shigeru Yamada, Masaru Miyazaki
BACKGROUND: Macroscopic vascular invasion (MVI) significantly impacts survival in patients with hepatocellular carcinoma (HCC), warranting systemic therapy over locoregional therapy. Despite novel approaches, HCC with MVI has a poor prognosis compared to early-to intermediate-stage HCC. This study aimed to evaluate the safety and efficacy of carbon-ion radiotherapy (C-ion RT) for HCC characterized by MVI. METHODS: This retrospective cohort study evaluated HCC patients with MVI treated using C-ion RT with a dose of 45...
March 26, 2024: BMC Cancer
https://read.qxmd.com/read/38532022/camptothecin-enhances-the-anti-tumor-effect-of-low-dose-apatinib-combined-with-pd-1-inhibitor-on-hepatocellular-carcinoma
#14
JOURNAL ARTICLE
Hankang Wang, Congcong Gao, Xiaodong Li, Feng Chen, Guijie Li
Apatinib has been shown to apply to a variety of solid tumors, including advanced hepatocellular carcinoma. Preclinical and preliminary clinical results confirmed the synergistic antitumor effects of apatinib in combination with anti-programmed death-1 (PD-1) inhibitors. In this study, we investigated camptothecin (CPT) enhances the anti-tumor effect of low-dose apatinib combined with PD-1 inhibitor on hepatocellular carcinoma. CPT combined with a PD-1 inhibitor enhances the anti-tumor effects of low-dose apatinib in hepatocellular carcinoma which was evaluated in making use of the H22 mouse model (n = 32), which was divided into four groups...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531953/prognosis-and-chemotherapy-drug-sensitivity-in-liver-hepatocellular-carcinoma-through-a-disulfidptosis-related-lncrna-signature
#15
JOURNAL ARTICLE
Chao Chen, Chaoyang Wang, Yi Li, Shanshan Jiang, Ningjun Yu, Guofeng Zhou
Disulfidptosis, a new type of regulated cell death associated with the actin cytoskeleton, provides a new therapeutic tool for cancers. The direct relationship between disulfidptosis-related lncRNAs(DRLs) in liver hepatocellular carcinoma(HCC) remains unclear. We acquired transcriptomic data, corresponding clinical data, and tumor mutation data of HCC from the TCGA database. First of all, DRLs were determined through correlation analysis. Then, a prognostic model containing six DRLs was created by adopting univariate Cox regression, LASSO algorithm and multivariate Cox regression analysis...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531699/unveiling-the-cancer-risk-nexus-of-the-steatotic-liver
#16
REVIEW
Jieun Kim, Ekihiro Seki
Steatotic liver, characterized by the accumulation of fat in the liver, poses significant health risks including metabolic dysfunction-associated steatotic liver disease (MASLD) and an elevated risk of primary liver cancer. Emerging evidence indicates a robust association between steatotic liver and increased susceptibility to extrahepatic primary cancers and their metastases. The deposition of fat induces dynamic changes in hepatic microenvironments, thereby fostering inflammation and immune responses that enhance liver metastasis from extrahepatic primary cancers...
March 25, 2024: Trends in Endocrinology and Metabolism: TEM
https://read.qxmd.com/read/38531501/effects-of-moderate-ethanol-exposure-on-risk-factors-for-cardiovascular-disease-and-colorectal-cancer-in-adult-wistar-rats
#17
JOURNAL ARTICLE
Anna J Kwon, Lani Morales, Louise Chatagnier, Jacqueline Quigley, Jeremy Pascua, Natalie Pinkowski, Susan M Brasser, Mee Young Hong
While past studies have provided evidence linking excessive alcohol consumption to increased risk for cardiovascular diseases (CVDs) and colorectal cancer (CRC), existing data on the effects of moderate alcohol use on these conditions have produced mixed results. The purpose of this study was to investigate the effects of moderate alcohol consumption on risk factors associated with the development of CVDs and CRC in adult rats. Twenty-four, 14-month-old, non-deprived male Wistar rats were randomly assigned to either an ethanol group, which consisted of voluntary access to a 20% (v/v) ethanol solution on alternate days, or a water control group (n = 12/group) for 13 weeks...
March 24, 2024: Alcohol
https://read.qxmd.com/read/38530952/a-case-series-of-choroidal-and-orbital-neuroendocrine-tumors-metastasis-2-patients-treated-with-prrt
#18
JOURNAL ARTICLE
Tony Zibo Zhuang, Chris Bergstrom, Bassel F El-Rayes, Walid L Shaib
Neuroendocrine tumors are rare cancers with heterogenous histologies, response to treatments and prognoses. Majority of these cancers originate in the gastrointestinal tract and metastasize to the liver. We are reporting 5 patients with low-grade neuroendocrine tumor disease with rare metastases to the choroids. Two of the patients were treated with peptide receptor radionuclide therapy (Lutitium-177). This is the first report confirming PRRT safety in patients with low grade NET with ocular metastases.
March 14, 2024: Pancreas
https://read.qxmd.com/read/38530557/efficacy-and-safety-of-anlotinib-plus-anti-pd-1-agents-in-patients-with-refractory-advanced-biliary-tract-cancers
#19
JOURNAL ARTICLE
Tianqi An, Qiu Hui, Hong Zong, Linhua Liu, Xinguang Cao, Rui Li, Shuang Hu, Yiyi Liu, Jia Li, Ruihua Zhao
BACKGROUND: Anlotinib has demonstrated promising anti-tumor efficacy in various solid tumors. Additionally, there is evidence suggesting that immune therapy can enhance the systemic responses of anlotinib. This study aimed to assess the effectiveness and safety of combining anlotinib with PD-1 inhibitors compared to fluoropyrimidine-based chemotherapy as a second-line treatment option for advanced biliary tract cancers (BTCs). METHODS: A total of 242 patients with BTCs were screened at the First Affiliated Hospital of Zhengzhou University from October 2015 to October 2022...
March 26, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38530254/concurrent-atezolizumab-plus-bevacizumab-and-high-dose-external-beam-radiotherapy-for-highly-advanced-hepatocellular-carcinoma
#20
JOURNAL ARTICLE
Chung-Wei Su, Wei Teng, Eric Yi-Liang Shen, Bing-Shen Huang, Po-Ting Lin, Ming-Mo Hou, Tsung-Han Wu, Din-Li Tsan, Chia-Hsun Hsieh, Ching-Ting Wang, Pei-Mei Chai, Chun-Yen Lin, Shi-Ming Lin, Chen-Chun Lin
BACKGROUND: Atezolizumab plus bevacizumab (atezo-bev) has been recommended for advanced hepatocellular carcinoma (HCC). High-dose external beam radiotherapy (RT) is recognized for its excellent local tumor control. The efficacy and safety of concurrent atezo-bev with RT for highly advanced HCC has been minimally explored. METHODS: In this preliminary retrospective study, we assessed patients with highly advanced HCC, characterized by Vp4 portal vein thrombosis or tumors exceeding 50% of liver volume, who received concurrent atezo-bev and RT (group A)...
March 26, 2024: Oncologist
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