Jean-Michel Gracies, Alberto Esquenazi, Allison Brashear, Marta Banach, Serdar Kocer, Robert Jech, Svetlana Khatkova, Ján Benetin, Michele Vecchio, Peter McAllister, Jan Ilkowski, Stanislaw Ochudlo, France Catus, Anne Sophie Grandoulier, Claire Vilain, Philippe Picaut
OBJECTIVE: To demonstrate single abobotulinumtoxinA injection efficacy in lower limb vs placebo for adults with chronic hemiparesis and assess long-term safety and efficacy of repeated injections. METHODS: In a multicenter, double-blind, randomized, placebo-controlled, single-cycle study followed by a 1-year open-label, multiple-cycle extension, adults ≥6 months after stroke/brain injury received one lower limb injection (abobotulinumtoxinA 1,000 U, abobotulinumtoxinA 1,500 U, placebo) followed by ≤4 open-label cycles (1,000, 1,500 U) at ≥12-week intervals...
November 28, 2017: Neurology