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https://www.readbyqxmd.com/read/27932866/effect-of-peritoneal-dialysis-fluid-containing-osmo-metabolic-agents-on-human-endothelial-cells
#1
Mario Bonomini, Sara Di Silvestre, Pamela Di Tomo, Natalia Di Pietro, Domitilla Mandatori, Lorenzo Di Liberato, Vittorio Sirolli, Francesco Chiarelli, Cesare Indiveri, Assunta Pandolfi, Arduino Arduini
BACKGROUND: The use of glucose as the only osmotic agent in peritoneal dialysis (PD) solutions (PDSs) is believed to exert local (peritoneal) and systemic detrimental actions, particularly in diabetic PD patients. To improve peritoneal biocompatibility, we have developed more biocompatible PDSs containing xylitol and carnitine along with significantly less amounts of glucose and have tested them in cultured Human Vein Endothelial Cells (HUVECs) obtained from the umbilical cords of healthy (C) and gestational diabetic (GD) mothers...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27930609/feasibility-and-acceptability-of-health-communication-interventions-within-a-combination-intervention-strategy-for-improving-linkage-and-retention-in-hiv-care-in-mozambique
#2
Roberta Sutton, Maria Lahuerta, Fatima Abacassamo, Laurence Ahoua, Maria Tomo, Matthew R Lamb, Batya Elul
BACKGROUND: Challenges to ensuring timely linkage to and retention in HIV care are well documented. Combination intervention strategies can be effective in improving the HIV care continuum. Data on feasibility and acceptability of intervention types within intervention packages are limited. METHODS: The Engage4Health study assessed the effectiveness of a combination intervention strategy to increase linkage and retention among adults newly diagnosed with HIV in Mozambique...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27928398/high-myopia-associated-with-triple-x-syndrome
#3
Tomo Nishi, Nahoko Ogata
We report our findings in a 3-year-old girl who was suspected of having triple X syndrome because she was taller than +4.35 standard deviations for her age. She also had high myopia. Optical coherence tomography (OCT) showed that her retinas were thin, the lenses were subluxated, and the axial length was elongated. Our findings indicate that for a female child with tall stature, there should be thorough evaluations for endocrinological disorders, overgrowth syndromes, connective tissue disorders, and genetic disorders...
June 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27926816/identification-of-polymerase-gene-mutations-that-affect-viral-replication-in-h5n1-influenza-viruses-isolated-from-pigeons
#4
Emad Mohamed Elgendy, Yasuha Arai, Norihito Kawashita, Tomo Daidoji, Tatsuya Takagi, Madiha Salah Ibrahim, Takaaki Nakaya, Yohei Watanabe
Highly pathogenic avian influenza virus H5N1 infects a wide range of host species, with a few cases of sporadic pigeon infections reported in the Middle East and Asia. However, the role of pigeons in the ecology and evolution of H5N1 viruses remains unclear. We previously reported two H5N1 virus strains, isolated from naturally infected pigeons in Egypt, that have several unique mutations in their viral polymerase genes. Here, we investigated the effect of these mutations on H5N1 polymerase activity and viral growth and identified three mutations that affected viral polymerase activity...
December 7, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27923011/feasibility-and-acceptability-of-health-communication-interventions-within-a-combination-intervention-strategy-for-improving-linkage-and-retention-in-hiv-care-in-mozambique
#5
Roberta Sutton, Maria Lahuerta, Fatima Abacassamo, Laurence Ahoua, Maria Tomo, Matthew R Lamb, Batya Elul
BACKGROUND: Challenges to ensuring timely linkage to and retention in HIV care are well documented. Combination intervention strategies can be effective in improving the HIV care continuum. Data on feasibility and acceptability of intervention types within intervention packages are limited. METHODS: The Engage4Health study assessed the effectiveness of a combination intervention strategy to increase linkage and retention among adults newly diagnosed with HIV in Mozambique...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27919974/a-phase-ii-study-of-adjuvant-chemotherapy-of-tegafur-uracil-for-patients-with-breast-cancer-with-her2-negative-pathologic-residual-invasive-disease-after-neoadjuvant-chemotherapy
#6
Satoru Tanaka, Mitsuhiko Iwamoto, Kosei Kimura, Yuko Takahashi, Hiyoya Fujioka, Nayuko Sato, Risa Terasawa, Kanako Kawaguchi, Ayana Ikari, Tomo Tominaga, Saki Maezawa, Nodoka Umezaki, Junna Matsuda, Kazuhisa Uchiyama
BACKGROUND: There is no consensus on the need for adjuvant chemotherapy for patients with pathological residual invasive breast cancer (non-pCR) after neoadjuvant chemotherapy (NAC). We evaluated the tolerability and safety of tegafur-uracil (UFT) as adjuvant chemotherapy for patients with human epidermal growth factor receptor 2-negative breast cancer that resulted in non-pCR after NAC. PATIENTS AND METHODS: We treated patients with 270 mg/m(2) UFT per day for 2 years after definitive surgery and radiotherapy, if necessary...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27897212/groundwater-helium-anomaly-reflects-strain-change-during-the-2016-kumamoto-earthquake-in-southwest-japan
#7
Yuji Sano, Naoto Takahata, Takanori Kagoshima, Tomo Shibata, Tetsuji Onoue, Dapeng Zhao
Geochemical monitoring of groundwater and soil gas emission pointed out precursor and/or coseismic anomalies of noble gases associated with earthquakes, but there was lack of plausible physico-chemical basis. A laboratory experiment of rock fracturing and noble gas emission was conducted, but there is no quantitative connection between the laboratory results and observation in field. We report here deep groundwater helium anomalies related to the 2016 Kumamoto earthquake, which is an inland crustal earthquake with a strike-slip fault and a shallow hypocenter (10 km depth) close to highly populated areas in Southwest Japan...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27894118/nutritional-status-and-changes-in-body-weight-in-patients-with-multiple-system-atrophy
#8
Tomoe Sato, Maho Shiobara, Masatoyo Nishizawa, Takayoshi Shimohata
INTRODUCTION: The importance of nutritional management in neurodegenerative diseases is increasingly recognized in the clinical setting. However, few reports have examined the nutritional intake in patients with multiple system atrophy (MSA). Here, we investigated changes in daily caloric intake, body mass index (BMI) and nutritional status during the disease course of MSA. METHODS: We performed a single-hospital study of 82 consecutive patients with probable MSA according to the consensus criteria...
November 29, 2016: European Neurology
https://www.readbyqxmd.com/read/27882236/improved-survival-with-double-platinum-therapy-transcatheter-arterial-infusion-using-cisplatin-and-transcatheter-arterial-chemoembolization-using-miriplatin-for-bclc-b-hepatocellular-carcinoma
#9
Toru Ishikawa, Satoshi Abe, Takayuki Watanabe, Yujiro Nozawa, Tomoe Sano, Akito Iwanaga, Keiichi Seki, Terasu Honma, Toshiaki Yoshida
Transcatheter arterial chemoembolization (TACE) is the standard therapy for Barcelona Clinic Liver Cancer (BCLC) classification intermediate stage B hepatocellular carcinoma (HCC). However, other transcatheter methods, such as transcatheter arterial infusion (TAI), also play an important role in the treatment of advanced HCC. Although it has been reported that TAI with a high concentration of a fine-powder formulation of cisplatin (DDP-H) reduced intrahepatic recurrence and improved survival, the combined use of TAI with DDP-H and TACE has not yet been investigated...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27879210/murine-transgenic-ips-cell-line-for-monitoring-and-selection-of-cardiomyocytes
#10
Azra Fatima, Guoxing Xu, Filomain Nguemo, Alexey Kuzmenkin, Karsten Burkert, Jürgen Hescheler, Tomo Šarić
We report here a transgenic murine induced pluripotent stem cell (iPSC) line expressing puromycin N-acetyltransferase (PAC) and enhanced green fluorescent protein (EGFP) under the control of α-myosin heavy chain promoter. This transgenic cell line reproducibly differentiates into EGFP-expressing cardiomyocytes (CMs) which can be generated at high purity with puromycin treatment and exhibit molecular and functional properties of immature heart muscle cells. This genetically modified iPSC line can be used for assessment of the utility of CMs for myocardial repair, pharmacological and toxicological applications and development of improved cardiac differentiation protocols...
September 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27875060/open-versus-thoracoscopic-rfa-assisted-lung-resection
#11
Anna Poupalou, Michael Kontos, Evangelos Felekouras, Apostolos Papalois, Nikolaos Kavantzas, George Agrogiannis, Fatima Yagoubi, Periklis Tomos
The purpose of this study was to evaluate Radio Frequency Ablation (RFA)-assisted lung parenchymal transection through thoracotomy and thoracoscopy. Twelve domestic pigs underwent RFA-assisted lingulectomy: six through thoracotomy (group A), and six with thoracoscopy (group B). There was no mortality, no bleeding, or air leak intra- or postoperatively in either of the groups, and no conversion to open thoracotomy in group B. Group A had longer operating period and more pleural adhesions. A barotrauma, a skin burn, and a localized infection were observed in this group...
November 22, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27867811/dramatic-mitigation-of-bone-pain-after-phosphorus-replacement-therapy-in-a-subject-with-fgf23-related-hypophosphatemic-osteomalacia
#12
Fuminori Tatsumi, Megumi Horiya, Akihito Tanabe, Momoyo Nishioka, Yoshiro Fushimi, Junpei Sanada, Yurie Hirata, Shintaro Irie, Tomoe Kinoshita, Shinji Kamei, Masashi Shimoda, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
INTRODUCTION: Fibroblast growth factor 23 (FGF23) is secreted from bone and suppresses the absorption of phosphorus in renal proximal tubule and in intestinal tract. Therefore, the increase of serum FGF23 levels leads to hypophosphatemic situations. Tumor-induced osteomalacia is often induced by various tumors, but it is often difficult to identify the localization of tumor, because most of the FGF23-producing tumors are small and could be observed in any part of the body. CASE DESCRIPTION: Here we report a case of elderly female subject with FGF23-related hypophosphatemic osteomalacia who repeatedly experienced severe bone pain and fragility fracture in various parts of the body...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27867470/effect-of-sevoflurane-anesthesia-on-the-comprehensive-mrna-expression-profile-of-the-mouse-hippocampus
#13
Tomo Hayase, Shunsuke Tachibana, Michiaki Yamakage
Postoperative nausea and vomiting (PONV) is a common complication after general anesthesia. Recent studies suggested that the hippocampus is involved in PONV. Hypothesising that hippocampal dopaminergic neurons are related to PONV, we examined the comprehensive mRNA profile of the hippocampus, using a sevoflurane-treated mouse model to confirm this. This study was conducted after approval from our institutional animal ethics committee, the Animal Research Center of Sapporo Medical University School of Medicine (project number: 12-033)...
April 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27866963/interdialytic-weight-gain-trends-predictors-and-associated-outcomes-in-the-international-dialysis-outcomes-and-practice-patterns-study-dopps
#14
Michelle M Y Wong, Keith P McCullough, Brian A Bieber, Juergen Bommer, Manfred Hecking, Nathan W Levin, William M McClellan, Ronald L Pisoni, Rajiv Saran, Francesca Tentori, Tadashi Tomo, Friedrich K Port, Bruce M Robinson
BACKGROUND: High interdialytic weight gain (IDWG) is associated with adverse outcomes in hemodialysis (HD) patients. We identified temporal and regional trends in IDWG, predictors of IDWG, and associations of IDWG with clinical outcomes. STUDY DESIGN: Analysis 1: sequential cross-sections to identify facility- and patient-level predictors of IDWG and their temporal trends. Analysis 2: prospective cohort study to assess associations between IDWG and mortality and hospitalization risk...
November 17, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27866023/direct-and-adjusted-indirect-comparisons-of-perioperative-mortality-after-sutureless-or-rapid-deployment-aortic-valve-replacement-versus-transcatheter-aortic-valve-implantation
#15
Hisato Takagi, Tomo Ando, Takuya Umemoto
OBJECTIVES: To determine which procedure, aortic valve replacement (AVR) with a sutureless or rapid-deployment prosthesis (SL-AVR) or transcatheter aortic valve implantation (TAVI), achieves better perioperative survival for severe aortic stenosis (AS), we conducted direct-comparison meta-analyses (DC-MAs) and an adjusted indirect-comparison meta-analysis (IDC-MA). METHODS: We searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials through April 2016...
November 12, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27865200/a-review-of-comparative-studies-of-mitraclip-versus-surgical-repair-for-mitral-regurgitation
#16
Hisato Takagi, Tomo Ando, Takuya Umemoto
OBJECTIVES: We summarized comparative studies of MitraClip versus surgical repair for mitral regurgitation (MR) with a systematic literature search and meta-analytic estimates. METHODS: MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched through June 2016. Eligible studies were randomized controlled or observational comparative studies of MitraClip versus surgical repair enrolling patients with MR and reporting early (30-day or in-hospital) or late (≥6-month including early) all-cause mortality...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27864658/conjugates-between-photosystem-i-and-a-carbon-nanotube-for-a-photoresponse-device
#17
Daisuke Nii, Mariko Miyachi, Yuichiro Shimada, Yosuke Nozawa, Masahiro Ito, Yoshikazu Homma, Shu Ikehira, Yoshinori Yamanoi, Hiroshi Nishihara, Tatsuya Tomo
Photosystem I (PS I) is a large pigment-protein complex embedded in the thylakoid membranes that performs light-driven electron transfer across the thylakoid membrane. Carbon nanotubes exhibit excellent electrical conductivities and excellent strength and stiffness. In this study, we generated PSI-carbon nanotube conjugates dispersed in a solution aimed at application in artificial photosynthesis. PS I complexes in which a carbon nanotube binding peptide was introduced into the middle of the PsaE subunit were conjugated on a single-walled carbon nanotube, orienting the electron acceptor side to the nanotube...
November 18, 2016: Photosynthesis Research
https://www.readbyqxmd.com/read/27862261/cell-surface-hydrophobicity-and-colony-morphology-of-trichosporon-asahii-clinical-isolates
#18
Tomoe Ichikawa, Chihiro Hirata, Mizuki Takei, Naoyuki Tagami, Hiromi Murasawa, Reiko Ikeda
Trichosporon asahii is a pathogenic basidiomycetous yeast. Individual strains of T. asahii have different colony morphologies. However, it is not clear whether cell surface phenotypes differ among the colony morphologies. Here we characterized the cell surface hydrophobicity and analysed the carbohydrate contents of the cell surface polysaccharides in T. asahii clinical isolates with various colony morphologies. Among the three distinctive colony morphologies obtained from one clinical isolate, the white-type morphology exhibited higher hydrophobicity...
November 8, 2016: Yeast
https://www.readbyqxmd.com/read/27851950/modeling-of-transmembrane-potential-in-realistic-multicellular-structures-before-electroporation
#19
Tomo Murovec, Daniel C Sweeney, Eduardo Latouche, Rafael V Davalos, Christian Brosseau
Many approaches for studying the transmembrane potential (TMP) induced during the treatment of biological cells with pulsed electric fields have been reported. From the simple analytical models to more complex numerical models requiring significant computational resources, a gamut of methods have been used to recapitulate multicellular environments in silico. Cells have been modeled as simple shapes in two dimensions as well as more complex geometries attempting to replicate realistic cell shapes. In this study, we describe a method for extracting realistic cell morphologies from fluorescence microscopy images to generate the piecewise continuous mesh used to develop a finite element model in two dimensions...
November 15, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27846755/primary-varicella-infection-in-children-with-systemic-juvenile-idiopathic-arthritis-under-tocilizumab-therapy
#20
Tomo Nozawa, Kenichi Nishimura, Asami Ohara, Ryoki Hara, Shuichi Ito
We report the clinical course and outcome of primary varicella infection in six children with systemic juvenile idiopathic arthritis (sJIA) receiving tocilizumab. None had disseminated or fatal varicella infection, but one patient developed macrophage activation syndrome (MAS) and another had an arthritis relapse. All patients had a significant elevation of serum IL-6 levels, and the two children who developed MAS or arthritis relapse showed high serum IL-18 levels, which could cause a sJIA flare-up.
November 16, 2016: Modern Rheumatology
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