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https://www.readbyqxmd.com/read/28107073/choroidal-vasculopathy-and-retinal-detachment-in-a-bald-eagle-haliaeetus-leucocephalus-with-lead-toxicosis
#1
Ramzi Eid, David Sanchez-Migallon Guzman, Krista A Keller, K Tomo Wiggans, Christopher J Murphy, Elise E B LaDouceur, M Kevin Keel, Christopher M Reilly
A subadult male bald eagle ( Haliaeetus leucocephalus ) was presented for severe depression and weakness. Physical examination findings included depressed mentation, dehydration, sternal recumbency, poor body condition, and bilateral, whole-head, horizontal nystagmus. A heavy-metal panel was performed, and blood lead levels were 6.1 ppm. Treatment for lead poisoning was initiated, including subcutaneous fluids and parenteral calcium-disodium ethylenediaminetetraacetic acid, ceftiofur, and meloxicam. Ophthalmic examination findings included absent menace response, absent dazzle reflex, slow and incomplete direct pupillary light reflex, mild anterior uveitis, incipient cataracts, multifocal retinal tears, and retinal separation in both eyes...
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28105285/structural-basis-for-the-effective-myostatin-inhibition-of-the-mouse-myostatin-prodomain-derived-minimum-peptide
#2
Tomo Asari, Kentaro Takayama, Akari Nakamura, Takahiro Shimada, Akihiro Taguchi, Yoshio Hayashi
Myostatin inhibition is one of the promising strategies for treating muscle atrophic disorders, including muscular dystrophy. It is well-known that the myostatin prodomain derived from the myostatin precursor acts as an inhibitor of mature myostatin. In our previous study, myostatin inhibitory minimum peptide 1 (WRQNTRYSRIEAIKIQILSKLRL-amide) was discovered from the mouse myostatin prodomain. In the present study, alanine scanning of 1 demonstrated that the key amino acid residues for the effective inhibitory activity are rodent-specific Tyr and C-terminal aliphatic residues, in addition to N-terminal Trp residue...
January 12, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28103045/photocurrent-generation-of-reconstituted-photosystem-ii-on-self-assembled-gold-film
#3
Mariko Miyachi, Shu Ikehira, Daiki Nishiori, Yoshinori Yamanoi, Masato Yamada, Masako Iwai, Tatsuya Tomo, Suleyman I Allakhverdiev, Hiroshi Nishihara
Photosystem II (PSII) modified gold electrodes were prepared by the deposition of PSII reconstituted with platinum nanoparticles (PtNPs) on Au electrodes. PtNPs modified with 1-[15-(3,5,6-trimethyl-1,4-benzoquinone-2-yl)]pentadecyl disulfide ((TMQ(CH2)15S)2) were incorporated into the QB site of PSII isolated from the thermophilic cyanobacterium, Thermosynechococcus elongatus. The reconstitution was confirmed by QA-reoxidation measurements. PSII reconstituted with PtNPs was deposited and integrated on a Au(111) surface modified with 4,4'-biphenyldithiol...
January 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28100994/reocclusion-after-self-expandable-metallic-stent-placement-for-relieving-malignant-colorectal-obstruction-as-a-palliative-treatment
#4
Toshikatsu Nitta, Kensuke Fujii, Yoshimasa Hirata, Tomo Tominaga, Yoshihiro Inoue, Hiroshi Kawasaki, Ken Kawakami, Takashi Ishibashi
Self-expandable metallic stent (SEMS) placement has been practiced in several hospitals in Japan, including ours, since January 2012. Here, we report the case of an 82-year-old Japanese man who presented to the hospital with a 1-week history of right hypochondrial pain. Computed tomography (CT) findings indicated colorectal cancer. The laboratory findings on admission indicated severe anemia (red blood cell count, 426 × 104/μL; hemoglobin, 7.9 g/dL). We performed SEMS placement because the patient refused to undergo surgery...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28100645/lipoxin-a4-stimulates-endothelial-mir-126-5p-expression-and-its-transfer-via-microvesicles
#5
Marilina Codagnone, Antonio Recchiuti, Paola Lanuti, Anna Maria Pierdomenico, Eleonora Cianci, Sara Patruno, Veronica Cecilia Mari, Felice Simiele, Pamela Di Tomo, Assunta Pandolfi, Mario Romano
The proresolution lipid mediator lipoxin (LX)A4 bestows protective bioactions on endothelial cells. We examined the impact of LXA4 on transcellular endothelial signaling via microRNA (miR)-containing microvesicles. We report LXA4 inhibition of MV release by TNF-α-treated HUVECs, associated with the down-regulation of 18 miR in endothelial microvesicles (EMVs) and the up-regulation of miR-126-5p, both in HUVECs and in EMVs. LXA4 up-regulated miR-126-5p by ∼5-fold in HUVECs and promoted a release of microvesicles (LXA4-EMVs) that enhanced miR-126-5p by ∼7-fold in recipient HUVECs...
January 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28096046/worse-late-phase-survival-after-elective-endovascular-than-open-surgical-repair-for-intact-abdominal-aortic-aneurysm
#6
Hisato Takagi, Tomo Ando, Takuya Umemoto
OBJECTIVES: To determine whether follow-up survival is better after elective endovascular aneurysm repair (EVAR) than open surgical repair (OSR) for intact abdominal aortic aneurysm (AAA), we combined 5-year survival curves themselves of EVAR and OSR in randomized controlled trials (RCTs) and propensity-score matched (PSM) studies. METHODS: Eligible studies were RCTs or PSM studies of elective EVAR versus OSR enrolling patients with intact AAA and reporting 5-year (at least) survival curves...
January 11, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28080904/photoreceptor-degeneration-in-a-mountain-lion-cub-puma-concolor
#7
Andrew R DiSalvo, Christopher M Reilly, K Tomo Wiggans, Leslie W Woods, Ray F Wack, Deana L Clifford
An orphaned 4-mo-old female mountain lion cub ( Puma concolor ) was captured along the coastline in Montaña de Oro State Park in Los Osos, California, USA. Following suspicion that the cub was visually impaired, ophthalmic examination revealed diffuse bilateral retinal atrophy. Due to a poor prognosis, humane euthanasia was elected. Necropsy and histopathological findings were consistent with photoreceptor degeneration. Based on the cub's signalment, history, and histopathology, a genetic or nutritional etiology was suspected, with the former etiology more strongly supported...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28066949/editorial-comment-to-are-complications-of-stress-urinary-incontinence-surgery-procedures-associated-with-the-position-of-the-sling
#8
Hikaru Tomoe
No abstract text is available yet for this article.
January 9, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28066576/to-complete-or-not-to-complete-that-is-the-question-of-revascularization-in-percutaneous-coronary-intervention-with-drug-eluting-stents-for-multivessel-disease
#9
EDITORIAL
Hisato Takagi, Tomo Ando, Takuya Umemoto
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28061474/tomotherapy-as-an-adjuvant-treatment-for-gastroesophageal-junction-and-stomach-cancer-may-reduce-bowel-and-bone-marrow-toxicity-compared-to-intensity-modulated-radiotherapy-and-volumetric-modulated-arc-therapy
#10
Xin Wang, Yuan Tian, Yuan Tang, Zhi-Hui Hu, Jia-Jia Zhang, Gui-Shan Fu, Pan Ma, Hua Ren, Tao Zhang, Ning Li, Wen-Yang Liu, Hui Fang, Ye-Xiong Li, Jing Jin
PURPOSE: To compare dosimetric parameters of intensity-modulated radiotherapy (IMRT), volumetric-modulated arc therapy (VMAT) and tomotherapy (TOMO) in the adjuvant treatment of gastroesophageal junction (GEJ)/stomach cancer. The planning goal was to maintain high target coverage while keeping the dose to the bowel and bone marrow (BM) as low as possible. MATERIALS AND METHODS: After curative surgery, 16 patients with GEJ/stomach cancer were re-planned by coplanar IMRT (five fixed beam), VMAT (double-arc), and TOMO...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28049259/relationship-of-aging-and-nutritional-status-to-innate-immunity-in-tube-fed-bedridden-patients
#11
Yoshiaki Takeuchi, Tomoe Tashiro, Takuya Yamamura, Seiichiro Takahashi, Kozo Katayose, Shin Kohga, Mitsunori Takase, Michio Imawari
BACKGROUND AND OBJECTIVES: Aging and malnutrition are known to influence immune functions. The aim of this study was to investigate the relationship of aging and malnutrition to innate immune functions in tube-fed bedridden patients. METHODS AND STUDY DESIGN: A cross-sectional survey was performed in 71 tube-fed bedridden patients aged 50-95 years (mean age±SD, 80.2±8.5 years) with serum albumin concentrations between 2.5 and 3.5 g/dL. We evaluated associations of age and nutritional variables with natural-killer cell activity, neutrophilphagocytic activity, and neutrophil-sterilizing activity...
January 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28047987/tu-g-pins-room-hall-e-01-hologic-tomosynthesis-synthesized-2d-tomo-guided-biopsy-and-dual-energy-imaging-system-design-principles-and-qc-protocols
#12
A Smith
This session along with the others on Digital Breast Tomosynthesis (DBT) offered at this years meeting as part of the Educational, Scientific and Partners in Solutions is intended to meet the FDA requirements for physicists to survey a DBT system. Specifically, this vendor offered session held as part of the Partners in Solutions is also meant to focus on those requirements. This session is being done along with the other two vendors of approved DBT systems in order to cover the machine specific features of those systems...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047842/su-f-t-420-dosimetry-comparison-of-advanced-external-beam-radiation-treatment-modalities-to-brachytherapy-treatments-in-patients-with-cervical-cancer
#13
U Mwidu, S Devic, M Shehadeh, M AlKafi, R Mahmood, B Moftah
PURPOSE: A retrospective comparison of dose distributions achievable by High dose rate brachytherapy (HDRBT), Helical TomoTherapy (TOMO), CyberKnife (CK) and RapidArc (RA) in locally advanced inoperable cervical cancer patients is presented. METHODS: Five patients with advanced stage cervical carcinoma were selected for this study after a full course of external beam radiotherapy (EBRT), chemotherapy and HDR Brachytherapy. To highlight any significant similarities/differences in dose distributions, high-risk clinical target volume (HRCTV) coverage, organs at risk (OAR) sparing, and machine specific delivery limitations, we used D90 (dose received by 90% of the volume) as the parameter for HRCTV coverage as recommended by the GEC-ESTRO Working Group...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047821/su-f-t-523-radiobiological-comparison-of-helical-tomotherapy-and-vmat-in-the-treatment-of-head-and-neck-tumors
#14
R Woods, P Mavroidis, M Lehman-Davis, M Kostich, T Cook, B Chera, S Das, J Lian
PURPOSE: This study aims at comparing the efficacy of Helical Tomotherapy (TOMO) and Volumetric Modulated Arc Therapy (VMAT) in producing highly conformal dose distributions in challenging head & neck cancer patients. Furthermore, to interpret the dosimetric findings into expected tissue response rates in order to estimate their clinical impact. METHODS: Seven patients were studied and for each patient two treatment plans (one TOMO and one VMAT) were created. Structures used for optimization were: high risk PTV, standard risk PTV, brainstem, spinal cord, parotid gland, larynx, mandible and surrounding tissue...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045457/endemicity-of-the-cosmopolitan-mesophilic-chemolithoautotroph-sulfurimonas-at-deep-sea-hydrothermal-vents
#15
Sayaka Mino, Satoshi Nakagawa, Hiroko Makita, Tomohiro Toki, Junichi Miyazaki, Stefan M Sievert, Martin F Polz, Fumio Inagaki, Anne Godfroy, Shingo Kato, Hiromi Watanabe, Takuro Nunoura, Koichi Nakamura, Hiroyuki Imachi, Tomo-O Watsuji, Shigeaki Kojima, Ken Takai, Tomoo Sawabe
Rich animal and microbial communities have been found at deep-sea hydrothermal vents. Although the biogeography of vent macrofauna is well understood, the corresponding knowledge about vent microbial biogeography is lacking. Here, we apply the multilocus sequence analysis (MLSA) to assess the genetic variation of 109 Sulfurimonas strains with ⩾98% 16S rRNA gene sequence similarity, which were isolated from four different geographical regions (Okinawa Trough (OT), Mariana Volcanic Arc and Trough (MVAT), Central Indian Ridge (CIR) and Mid-Atlantic Ridge (MAR))...
January 3, 2017: ISME Journal
https://www.readbyqxmd.com/read/28028262/-maintenance-of-long-term-stable-disease-sd-in-metastatic-breast-cancer-with-eribulin-a-case-report-of-long-term-sd-in-japan
#16
Toshikatsu Nitta, Kousei Kimura, Tomo Tominaga, Kensuke Fujii, Nayuko Sato, Ayana Ikari, Kazuhiro Miyoshi, Satoru Tanaka, Takashi Ishibashi, Mitsuhiko Iwamoto
This case report discusses a 48-year-old woman with metastatic breast cancer: T4c(10.5 cm)N2bM1,(OSS, LYM), stage IV, estrogen receptor(ER)(+), progesterone receptor(PgR)(+), human epidermal growth factor receptor-2(HER2) (-), and Ki-67 17.2%. Administration of eribulin was initiated after treatment with anthracycline and taxane. Thereafter, 28 courses of eribulin maintained a SD state for over a year and improved the quality of life(QOL). Eribulin is effective for both prolonging life and improving QOL, which are the main goals in the treatment of metastatic or recurrent cancer...
December 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28009035/unilateral-hypertransparency-on-chest-radiograph-the-congenital-poland-syndrome
#17
Ioannis Tomos, Andriana I Papaioannou, Aikaterini Vlami, Vasiliki Apollonatou, Effrosyni D Manali, Spyros A Papiris
Unilateral hypertransparent hemithorax requires a particular diagnostic approach as it can be the result of diverse pulmonary diseases, including pneumothorax, large pulmonary embolus, unilateral large bullae, mucous plag, airway obstruction and contralateral pleural effusion. Congenital syndromes with chest wall abnormalities, are rare, but often underdiagnosed causes. Poland Syndrome consists of such a rare, congenital anomaly and is characterized by the absence of the pectoralis major muscle and upper limb ipsilateral abnormalities...
2016: Adv Respir Med
https://www.readbyqxmd.com/read/28003584/integrated-next-generation-sequencing-analysis-of-whole-exome-and-409-cancer-related-genes
#18
Yuji Shimoda, Takeshi Nagashima, Kenichi Urakami, Tomoe Tanabe, Junko Saito, Akane Naruoka, Masakuni Serizawa, Tohru Mochizuki, Keiichi Ohshima, Sumiko Ohnami, Shumpei Ohnami, Masatoshi Kusuhara, Ken Yamaguchi
The use of next-generation sequencing (NGS) techniques to analyze the genomes of cancer cells has identified numerous genomic alterations, including single-base substitutions, small insertions and deletions, amplification, recombination, and epigenetic modifications. NGS contributes to the clinical management of patients as well as new discoveries that identify the mechanisms of tumorigenesis. Moreover, analysis of gene panels targeting actionable mutations enhances efforts to optimize the selection of chemotherapeutic regimens...
2016: Biomedical Research
https://www.readbyqxmd.com/read/28003583/optimizing-an-ion-semiconductor-sequencing-data-analysis-method-to-identify-somatic-mutations-in-the-genomes-of-cancer-cells-in-clinical-tissue-samples
#19
Takeshi Nagashima, Yuji Shimoda, Tomoe Tanabe, Akane Naruoka, Junko Saito, Masakuni Serizawa, Keiichi Ohshima, Kenichi Urakami, Sumiko Ohnami, Shumpei Ohnami, Tohru Mochizuki, Masatoshi Kusuhara, Ken Yamaguchi
Identification of causal genomic alterations is an indispensable step in the implementation of personalized cancer medicine. Analytical methods play a central role in identifying such changes because of the vast amount of data produced by next generation sequencer. Most analytical techniques are designed for the Illumina platform and are therefore suboptimal for analyzing datasets generated by whole exome sequencing (WES) using the Ion Proton System. Accurate identification of somatic mutations requires the characterization of platform-dependent error profiles and genomic properties that affect the accuracy of sequence data as well as platform-oriented optimization of the pipeline...
2016: Biomedical Research
https://www.readbyqxmd.com/read/28003445/distance-decay-effect-in-stone-tool-transport-by-wild-chimpanzees
#20
Lydia V Luncz, Tomos Proffitt, Lars Kulik, Michael Haslam, Roman M Wittig
Stone tool transport leaves long-lasting behavioural evidence in the landscape. However, it remains unknown how large-scale patterns of stone distribution emerge through undirected, short-term transport behaviours. One of the longest studied groups of stone-tool-using primates are the chimpanzees of the Taï National Park in Ivory Coast, West Africa. Using hammerstones left behind at chimpanzee Panda nut-cracking sites, we tested for a distance-decay effect, in which the weight of material decreases with increasing distance from raw material sources...
December 28, 2016: Proceedings. Biological Sciences
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