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https://www.readbyqxmd.com/read/28722780/add-on-effects-of-fluvastatin-in-simeprevir-pegylated-interferon-ribavirin-combination-therapy-for-patients-with-genotype-1-hepatitis-c-virus-infection-a-randomized-controlled-study
#1
Goki Suda, Jun Ito, Atsushi Nagasaka, Yoshiya Yamamoto, Ken Furuya, Munenori Okamoto, Katsumi Terashita, Tomoe Kobayashi, Izumi Tsunematsu, Junichi Yoshida, Takashi Meguro, Masatsugu Ohara, Naoki Kawagishi, Megumi Kimura, Machiko Umemura, Takaaki Izumi, Yoko Tsukuda, Masato Nakai, Takuya Sho, Mitsuteru Natsuizaka, Kenichi Morikawa, Koji Ogawa, Naoya Sakamoto
BACKGROUND: The Japan Society of Hepatology guidelines indicate that HCV protease inhibitor combination therapy with simeprevir (SMV), pegylated-interferon (Peg-IFN), and ribavirin (RBV) is a therapeutic option for patients who fail to respond to a direct direct-acting antiviral (DAA) containing regimen. However, treatment outcomes have room for improvement. Fluvastatin (FLV) add-on treatment in Peg-IFN and RBV combination therapy for hepatitis C-infected patients significantly improved the sustained virological response (SVR), but the add-on effect of FLV on SMV combination therapy is not well understood...
July 19, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28721651/in-vitro-anti-inflammatory-and-antioxidant-activities-of-3-5-4-trihydroxy-6-7-methylenedioxyflavone-o-glycosides-and-their-aglycone-from-leaves-of-polygonum-tinctorium-lour
#2
Shota Tokuyama-Nakai, Hideto Kimura, Tomoe Ishihara, Mitsuo Jisaka, Kazushige Yokota
Polygonum tinctorium Lour (indigo plant) has been regarded as a useful medicinal plant for traditional herbal medicine. The polyphenolic fraction of indigo leaves exhibited anti-inflammatory activities as determined by the suppressed synthesis of nitric oxide (NO) in cultured RAW264 macrophage cells. The acid hydrolysate of the fraction showed much more potent effect than the unhydrolyzed one. In sharp contrast, those fractions of indigo stems had almost no effect. 3,5,4'-Trihydroxy-6,7-methylenedioxyflavone (TMF)-O-glycosides and tryptanthrin were detected exclusively in the extracts of the leaves...
July 18, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28714615/-arni-new-abbreviation-for-a-new-class-of-treatment-of-heart-failure
#3
Soran Karimzadeh, Hazrije Mustafić, Tomoe Stampfli Andres
ARNI (Angiontensin Receptor Neprilysin Inhibitor) are a new class of drug : the angiotensin and neprilysin inhibitors. This combined effect allows an optimisation of the heart failure treatment by acting on both pathways of the renin-angiotensin-aldosterone and of the natriuretic peptides. LCZ696 is a combined molecule of valsartan and sacubitril and is currently the only one on the market. Its efficacy has been shown in a large randomised trial in 2014, and LCZ696 is now part of the last 2016 European Society of Cardiology guidelines for the management of heart failure...
March 1, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28714613/le-d%C3%A3-fi-de-la-m%C3%A3-decine-connect%C3%A3-e
#4
EDITORIAL
Tomoe Stampfli Andres, Chan-Il Park, Edoardo De Benedetti
No abstract text is available yet for this article.
March 1, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28710555/efficacy-of-the-traditional-japanese-medicine-goreisan-for-the-resolution-of-spermatic-cord-hydrocele-in-children
#5
Noriko Takeda, Kiyoshi Tanaka, Eiichiro Watanabe, Tomo Kakihara, Masahiko Watanabe, Hisayoshi Kawahara
PURPOSE: Goreisan, a traditional Japanese medicine, has previously been used for hydrostatic modulation. This retrospective study investigated the efficacy of goreisan for spermatic cord hydrocele resolution in children. METHODS: Seventy-two boys treated for spermatic cord hydrocele between 2012 and 2015 were included; Goreisan was administered to 16 [group G, median age 3 (1-8) years], and 56 were followed without medication [group C, median age 1 (0-8) years]...
July 14, 2017: Surgery Today
https://www.readbyqxmd.com/read/28702898/perioperative-depression-or-anxiety-and-postoperative-mortality-in-cardiac-surgery-a-systematic-review-and-meta-analysis
#6
Hisato Takagi, Tomo Ando, Takuya Umemoto
We performed a systematic review and meta-analysis to determine whether perioperative depression and anxiety are associated with increased postoperative mortality in patients undergoing cardiac surgery. MEDLINE and EMBASE were searched through January 2017 using PubMed and OVID, to identify observational studies enrolling patients undergoing cardiac surgery and reporting relative risk estimates (RREs) (including odds, hazard, or mortality ratios) of short term (30 days or in-hospital) and/or late all-cause mortality for patients with versus without perioperative depression or anxiety...
July 13, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28702164/a-case-of-an-anomalous-biliary-tract-diagnosed-preoperatively
#7
Jun Kataoka, Toshikatsu Nitta, Yoshihiro Inoue, Masato Ota, Tomo Tominaga, Kensuke Fujii, Hiroshi Kawasaki, Takashi Ishibashi
We describe a 48-year-old man with cholecystolithiasis whose preoperative magnetic resonance cholangiopancreatography (MRCP) scan showed that the right accessory hepatic duct branching from the cystic duct dominated an anterior segment of the right hepatic lobe. We observed the right accessory hepatic duct using intraoperative cholangiography, and we were able to perform laparoscopic cholecystectomy without injuring it. He had no complication after discharge, and a drip-infusion cholangiography-computed tomography (DIC-CT) scan demonstrated that the right accessory hepatic duct was intact, and it dominated an anterior segment of the right hepatic lobe...
June 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28693381/a-meta-analysis-of-weekend-admission-and-surgery-for-aortic-rupture-and-dissection
#8
Hisato Takagi, Tomo Ando, Takuya Umemoto
We performed a meta-analysis to determine whether weekend admission and surgery for ruptured abdominal/thoracic aortic aneurysm (RAAA/RTAA) and acute aortic dissection (AAD) is associated with increased mortality. MEDLINE and EMBASE were searched from January 1946 to December 2016 using PubMed and OVID. Eligible studies were prospective or retrospective, comparative or cohort studies enrolling patients admitting or undergoing surgery for RAAA/RTAA/AAD and reporting mortality after weekend (including holiday) versus weekday admission/surgery...
July 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28689162/imaging-phospholipid-conformational-disorder-and-packing-in-giant-multilamellar-liposome-by-confocal-raman-microspectroscopy
#9
Hemanth Noothalapati, Keita Iwasaki, Chikako Yoshimoto, Keisuke Yoshikiyo, Tomoe Nishikawa, Masahiro Ando, Hiro-O Hamaguchi, Tatsuyuki Yamamoto
Liposomes are closed phospholipid bilayer systems that have profound applications in fundamental cell biology, pharmaceutics and medicine. Depending on the composition (pure or mixture of phospholipids, presence of cholesterol) and preparation protocol, intra- and inter-chain molecular interactions vary leading to changes in the quality (order and packing) of liposomes. So far it is not possible to image conformational disorders and packing densities within a liposome in a straightforward manner. In this study, we utilized confocal Raman microspectroscopy to visualize structural disorders and packing efficiency within a giant multilamellar liposome model by focusing mainly on three regions in the vibrational spectrum (CC stretching, CH deformation and CH stretching)...
July 1, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28688530/japanese-standard-for-clinical-stabilometry-assessment-current-status-and-future-directions
#10
REVIEW
Masahiko Yamamoto, Kazuo Ishikawa, Mitsuhiro Aoki, Keisuke Mizuta, Yatsuji Ito, Masatsugu Asai, Hideo Shojaku, Toshiaki Yamanaka, Chisato Fujimoto, Toshihisa Murofushi, Tomoe Yoshida
Stabilometry is a useful tool for examining patients with functional disorders of the vestibular system. However, measurement techniques and devices vary by country. Therefore, international standardization of stabilometry is mandatory to validate the exchange of important findings. This was advocated at the 1983 Posturography Meeting in Kyoto but has not been adopted worldwide, and each country has continued to use unique regional measurement methods. In Japan, stabilometry has widespread application in medical practice in conjunction with research into its applications...
July 5, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28685077/effect-of-treatment-support-on-preventing-local-recurrence-of-hepatocellular-carcinoma-directly-adjacent-to-the-diaphragm
#11
Toru Ishikawa, Michitaka Imai, Masayoshi Ko, Hiroki Sato, Yujiro Nozawa, Tomoe Sano, Akito Iwanaga, Keiichi Seki, Terasu Honma, Toshiaki Yoshida
Treatment support is anticipated to improve the results of radiofrequency ablation (RFA) treatment in cases in which visualization of tumors using the conventional B-mode is unclear. In the present study, the effectiveness of treatment support for RFA reducing the local recurrence rate of hepatocellular carcinoma (HCC) that are located directly adjacent to the diaphragm, and which are difficult to visualize with B-mode ultrasound imaging, was investigated. A total of 103 HCC tumors measuring <5 cm, which were located abutting the diaphragm, and which were difficult to visualize using the B-mode, were treated using RFA...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28683736/security-controls-in-an-integrated-biobank-to-protect-privacy-in-data-sharing-rationale-and-study-design
#12
Takako Takai-Igarashi, Kengo Kinoshita, Masao Nagasaki, Soichi Ogishima, Naoki Nakamura, Sachiko Nagase, Satoshi Nagaie, Tomo Saito, Fuji Nagami, Naoko Minegishi, Yoichi Suzuki, Kichiya Suzuki, Hiroaki Hashizume, Shinichi Kuriyama, Atsushi Hozawa, Nobuo Yaegashi, Shigeo Kure, Gen Tamiya, Yoshio Kawaguchi, Hiroshi Tanaka, Masayuki Yamamoto
BACKGROUND: With the goal of realizing genome-based personalized healthcare, we have developed a biobank that integrates personal health, genome, and omics data along with biospecimens donated by volunteers of 150,000. Such a large-scale of data integration involves obvious risks of privacy violation. The research use of personal genome and health information is a topic of global discussion with regard to the protection of privacy while promoting scientific advancement. The present paper reports on our plans, current attempts, and accomplishments in addressing security problems involved in data sharing to ensure donor privacy while promoting scientific advancement...
July 6, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28675678/3d-bioprinting-and-the-current-applications-in-tissue-engineering
#13
REVIEW
Ying Huang, Xiao-Fei Zhang, Guifang Gao, Tomo Yonezawa, Xiaofeng Cui
Bioprinting as an enabling technology for tissue engineering possesses the promises to fabricate highly mimicked tissue or organs with digital control. As one of the biofabrication approaches, bioprinting has the advantages of high throughput and precise control of both scaffold and cells. Therefore, this technology is not only ideal for translational medicine but also for basic research applications. Bioprinting has already been widely applied to construct functional tissues such as vasculature, muscle, cartilage, and bone...
July 4, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28674271/pharmacological-properties-of-various-anesthetic-protocols-in-10-day-old-neonatal-rats
#14
Atsushi Tsukamoto, Yui Konishi, Takako Kawakami, Chiharu Koibuchi, Reiichiro Sato, Eiichi Kanai, Tomo Inomata
In general, the anesthesia in neonates involves high risk. Although hypothermic anesthesia is recommended in rats up to the age of 7 days, neonatal anesthesia for later periods has not been standardized. The present study investigated the pharmacological properties of conventional anesthetic protocols in 10-day-old SD rats. The rats were anesthetized with four anesthetics: a combination of ketamine and xylazine (K/X); a combination of medetomidine, midazolam, and butorphanol (M/M/B); isoflurane; and sevoflurane...
June 30, 2017: Experimental Animals
https://www.readbyqxmd.com/read/28664019/crowned-dens-syndrome-occurred-in-a-patient-after-simple-drainage-for-chronic-subdural-hematoma-a-case-report
#15
Ryota Tamura, Satoshi Takahashi, Dai Kamamoto, Tomo Horikoshi, Kazunari Yoshida
Crowned dens syndrome (CDS) is a rare disease which presents with neck pain and rigidity. A 74-year-old man with right chronic subdural hematoma (CSDH) underwent hematoma drainage. After the operation, he complained of neck pain and laboratory test revealed elevation of C-reactive protein (CRP) and white blood cell (WBC). Suspecting localized infection, wound irrigation was performed. Neck pain relieved after irrigation, but we could not find the source of infection. CDS was diagnosed by computed tomography (CT)...
January 2017: NMC Case Rep J
https://www.readbyqxmd.com/read/28661095/protein-concentration-of-refractory-ascites-in-cancer-patients-is-reflected-by-the-presence-and-severity-of-peritoneal-and-liver-metastasis
#16
Yosuke Yamada, Akinori Yamaguchi, Makoto Harada, Yukifumi Kurasawa, Yuuta Hara, Daiki Yamazaki, Satoshi Fujita, Kosuke Sonoda, Tomoe Masuda, Aiko Yamada, Yohei Ogawa, Koji Hashimoto, Yuji Kamijo
Ascites total protein concentration (A-TP) affects the performance of cell-free and concentrated ascites reinfusion therapy (CART). As the factors determining A-TP remain unclear, we examined peritoneal and liver metastasis. Among 98 patients who received CART, 68 with cancer, ascites from no other apparent cause, and complete CT and A-TP data were recruited. Sixty-six patients (97%) with peritoneal and/or liver metastasis on CT were divided into the peritoneal metastasis group (PM group), peritoneal and liver metastasis group (PM + LM group), and liver metastasis group (LM group)...
June 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28658944/hydraulic-retention-time-and-ph-affect-the-performance-and-microbial-communities-of-passive-bioreactors-for-treatment-of-acid-mine-drainage
#17
Tomo Aoyagi, Takaya Hamai, Tomoyuki Hori, Yuki Sato, Mikio Kobayashi, Yuya Sato, Tomohiro Inaba, Atsushi Ogata, Hiroshi Habe, Takeshi Sakata
For acceleration of removing toxic metals from acid mine drainage (AMD), the effects of hydraulic retention time (HRT) and pH on the reactor performance and microbial community structure in the depth direction of a laboratory-scale packed-bed bioreactor containing rice bran as waste organic material were investigated. The HRT was shortened stepwise from 25 to 12 h, 8 h, and 6 to 5 h under the neutral condition using AMD neutralized with limestone (pH 6.3), and from 25 to 20 h, 12 h, and 8 to 7 h under the acid condition using AMD (pH 3...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28655943/lesion-size-on-ultrasonography-predicts-potential-invasion-in-ductal-carcinoma-in-situ-preoperatively-diagnosed-by-breast-needle-biopsy
#18
Kyoko Shimoyama, Tomo Osako, Toshiharu Mitsuhashi, Futoshi Akiyama, Takuji Iwase
Ductal carcinoma in situ (DCIS) of the breast has no potential to metastasize, but over 20% of cases preoperatively diagnosed as DCIS are upstaged on final pathology. The rates of upstaging and the predictors for invasion on final pathology were evaluated. For 240 primary breast cancers, radiological findings on mammography, ultrasonography, and magnetic resonance imaging were investigated along with pathological and clinical information. Univariate and multivariate analyses were performed to identify predictors of potential invasion...
June 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28654310/unique-infectious-strategy-of-h5n1-avian-influenza-virus-is-governed-by-the-acid-destabilized-property-of-hemagglutinin
#19
Tomo Daidoji, Yohei Watanabe, Yasuha Arai, Junichi Kajikawa, Ryohei Hirose, Takaaki Nakaya
Highly pathogenic avian influenza (HPAI) H5N1 virus emerged in 1997 as a zoonotic disease in Hong Kong. It has since spread to Asia and Europe and is a serious threat to both the poultry industry and human health. For effective surveillance and possible prevention/control of HPAI H5N1 viruses, it is necessary to understand the molecular mechanism underlying HPAI H5N1 pathogenesis. The hemagglutinin (HA) protein of influenza A viruses (IAVs) is one of the major determinants of host adaptation, transmissibility, and viral virulence...
July 2017: Viral Immunology
https://www.readbyqxmd.com/read/28648392/meta-analysis-of-seasonal-incidence-of-aortic-dissection
#20
Hisato Takagi, Tomo Ando, Takuya Umemoto
We performed the first meta-analysis to identify in which season incidence of aortic dissection is the most and least frequent. MEDLINE and EMBASE were searched through February 2017. Eligible studies were observational studies enrolling patients with aortic dissection and reporting seasonal or monthly incidence of aortic dissection. Study-specific estimates, incidence of aortic dissection in each season (number of aortic dissection in a season divided by that in a year) and risk ratios (RRs) for incidence of aortic dissection in a season versus another season, were combined using the random-effects model...
May 30, 2017: American Journal of Cardiology
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