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Tomoko Kubori, Tomoe Kitao, Hiroki Ando, Hiroki Nagai
The intracellular bacterial pathogen Legionella pneumophila establishes the replicative niche as a result of the actions of a large array of effector proteins delivered via the Legionella type IV secretion system (T4SS). Many effector proteins are expected to be involved in biogenesis and regulation of the Legionella-containing vacuole (LCV) that is highly decorated with ubiquitin. Here, we identified a Legionella deubiquitinase (DUB), designated LotA, by carrying out a genome analysis to find proteins resembling the eukaryotic ovarian tumor (OTU) superfamily of cysteine proteases...
March 15, 2018: Cellular Microbiology
Eleftherios Spartalis, Michael Spartalis, Demetrios Moris, Antonios Athanasiou, Theodore Troupis, Periklis Tomos
Congenital bronchopulmonary malformations are usually asymptomatic. Precise multimodality imaging plays an essential role in the identification of rare cardiothoracic entities, offering excellent imaging quality and the decisive diagnosis.
March 2018: Clinical Case Reports
Chakradhari Inampudi, Emmanuel Akintoye, Tomo Ando, Alexandros Briasoulis
Peripheral arterial disease (PAD) refers to narrowing of the peripheral arteries and atherosclerosis is the most important cause. In patients with PAD, revascularization is the preferred therapeutic strategy; nonetheless several patients are not deemed candidates for it due to advanced disease or several comorbidities. The main target of therapeutic angiogenesis is to promote development of new arterial vessels and improve perfusion of ischemic tissue. Angiogenic growth factors such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), hepatocyte growth factor (HGF), administered intramuscularly or intra-arterially, have been shown to promote angiogenesis and development of collateral vasculature in preclinical studies...
March 9, 2018: Current Opinion in Pharmacology
Shuhei Nakanishi, Masahiro Iwamoto, Hidenori Hirukawa, Masashi Shimoda, Fuminori Tatsumi, Kenji Kohara, Atsushi Obata, Seizo Okauchi, Tomoe Kinoshita, Junpei Sanada, Yoshiro Fushimi, Momoyo Nishioka, Akiko Mizoguchi, Miyuki Kameyama, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
We retrospectively evaluated the effects of mild physical exercise (P) in a routine clinical setting on glycemic and body-weight control in Japanese type 2 diabetes patients with and without individualized nutritional therapy (D). We analyzed 49 patients who participated in P that measured 2.5 METs and was held once every two weeks, compared with 83 non-participant controls, followed over a period of about 1.6 years. With a Cox model, the adjusted hazard ratio (HR) for improved HbA1c by numerical count of P was 1...
March 11, 2018: Journal of Diabetes Investigation
Shinji Kamei, Masahiro Iwamoto, Miyuki Kameyama, Masashi Shimoda, Tomoe Kinoshita, Atsushi Obata, Tomohiko Kimura, Hidenori Hirukawa, Fuminori Tatsumi, Kenji Kohara, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
Sodium-glucose cotransporter 2 inhibitor tofogliflozin is a new type of antidiabetic drug for individuals with type 2 diabetes mellitus (T2DM). The aim of this study was to examine in which type of individuals and/or under which conditions tofogliflozin could exert more beneficial effects on body composition and/or glycemic control in Japanese individuals with T2DM. We retrospectively evaluated the effects of tofogliflozin on body composition and/or glycemic control in individuals with T2DM who newly started taking tofogliflozin...
2018: Journal of Diabetes Research
Yayoi Shimazu, Tatsuki Uchiyama, Chisaki Mizumoto, Tomoharu Takeoka, Masaaki Tsuji, Kenjiro Tomo, Koji Takaori, Naoki Sakai, Tomoko Okuno, Tatsuharu Ohno
IgG4-related disease (IgG4RD) is a multi-organ disorder characterized by an elevated serum IgG4 level and IgG4-positive plasma cell infiltration of the affected organs, accompanied by tissue fibrosis and sclerosis. Although it can affect any organ, to our knowledge, no cases involving concurrent autoimmune neutropenia and thrombocytopenia have been reported. A 62-year-old man visited our hospital and was diagnosed with IgG4RD accompanied by interstitial pneumonitis, lymphadenopathy, and interstitial nephritis...
February 28, 2018: Internal Medicine
Ichiro Horie, Norio Abiru, Mami Eto, Ayaka Sako, Junya Akeshima, Tomoe Nakao, Yomi Nakashima, Tetsuro Niri, Ayako Ito, Aya Nozaki, Ai Haraguchi, Satoru Akazawa, Yoshitaka Mori, Takao Ando, Atsushi Kawakami
It has been reported that glucose responses during the oral glucose tolerance test (OGTT) differ between healthy females and males. However, it remains unknown what factors contribute to these differences between sexes. The present study analyzed the insulin and glucagon responses during OGTT in 25 female and 38 male young healthy adults age 22 to 30 years. The plasma glucose levels at 120 min were significantly higher in females than males. Insulin secretion was significantly greater at 30, 90 and 120 min from baseline in females than males...
February 28, 2018: Journal of Diabetes Investigation
Naoki Misawa, Takahiro Hosoya, Shuhei Yoshida, Osamu Sugimoto, Tomoe Yamada-Kato, Shigenori Kumazawa
To investigate the compounds present in wasabi leaves (Wasabia japonica Matsumura) that inhibit the adipocyte differentiation, activity-guided fractionation was performed on these leaves. 5-Hydroxyferulic acid methyl ester (1: 5-HFA ester), one of the phenylpropanoids, was isolated from wasabi leaves as a compound that inhibits the adipocyte differentiation. Compound 1 suppressed the intracellular lipid accumulation of 3T3-L1 cells without significant cytotoxicity. Gene expression analysis revealed that 1 suppressed the mRNA expression of 2 master regulators of adipocyte differentiation, PPARγ and C/EBPα...
February 26, 2018: Phytotherapy Research: PTR
Tomoe Hirota, Tomoaki Morioka, Koichiro Yoda, Norikazu Toi, Noriyuki Hayashi, Saori Maruo, Yuko Yamazaki, Masafumi Kurajoh, Koka Motoyama, Shinsuke Yamada, Tetsuo Shoji, Masanori Emoto, Masaaki Inaba
AIMS/INTRODUCTION: Poor sleep quality is associated with obesity and diabetes. The adipocyte-derived hormone leptin was recently shown to underlie the link between abnormal sleep and obesity. We aimed to investigate the association between leptin and sleep quality in type 2 diabetic patients. MATERIALS AND METHODS: In this cross-sectional study, we studied 182 type 2 diabetic patients, among whom 113 were diagnosed with obesity (body mass index ≥ 25 kg/m2 ). Fasting plasma leptin levels were measured, and sleep architecture was assessed using single-channel electroencephalography...
February 26, 2018: Journal of Diabetes Investigation
Natasa Popovic, Miroslav Radunovic, Jelena Badnjar, Tomo Popovic
Hypertension and diabetes mellitus represent modifiable risk factors for vascular disease. They cause microvascular remodeling, and ultimately result in end-organ damage. Therefore, development of methods for noninvasive quantification of the effects of hypertension and diabetes mellitus on microvasculature is of paramount importance. The two goals of the study were: 1) to characterize the geometric complexity and inhomogeneity of retinal vasculature in hypertensive retinopathy (HR) and in proliferative diabetic retinopathy (PDR) by using box counting fractal dimension and lacunarity analysis, and 2) to determine if the combination of these two parameters can be used to describe differences in the vascular tree geometry between HR and PDR...
February 21, 2018: Microvascular Research
Masafumi Ota, Tomomitsu Tahara, Toshimi Otsuka, Wu Jing, Tomoe Nomura, Ranji Hayashi, Takeo Shimasaki, Masakatsu Nakamura, Tomoyuki Shibata, Tomiyasu Arisawa
The present study aimed to investigate whether single nucleotide polymorphisms in receptor interacting serine/threonine kinase 2 ( RIPK2 ), which encodes a component of the nucleotide binding oligomerization domain containing 2-RIP2 pathway, may compromise the innate immune response to Helicobacter pylori infection, leading to increased susceptibility to gastric cancer in the Japanese population. The present case control study investigated the associations between RIPK2 single nucleotide polymorphisms and gastric mucosal inflammation, atrophy and cancer susceptibility in 528 patients with gastric cancer and 697 patients without gastric malignancies on upper gastro-duodenal endoscopy...
March 2018: Oncology Letters
Takuhiro Uto, Nguyen Huu Tung, Tomoe Ohta, Wipawee Juengsanguanpornsuk, Le Quoc Hung, Nguyen Thanh Hai, Dinh Doan Long, Phuong Thien Thuong, Shinya Okubo, Sakiko Hirata, Yukihiro Shoyama
In this study, we found that the hexane fraction of Danshen, the dried root of Salvia miltiorrhiza (Lamiaceae), exerted antiproliferative effects on human leukemia cells. Phytochemical investigation of the hexane fraction achieved the isolation of the tanshinone diterpenes: dihydrotanshinone I (1), trijuganone C (2), trijuganone B (3), cryptotanshinone (4), tanshinone IIA (5), and tanshinone I (6). Compound 2 showed significant antiproliferative activities against human leukemia cells HL-60, Jurkat, and U937...
February 21, 2018: Phytotherapy Research: PTR
Kosuke Minaga, Mamoru Takenaka, Ken Kamata, Tomoe Yoshikawa, Atsushi Nakai, Shunsuke Omoto, Takeshi Miyata, Kentaro Yamao, Hajime Imai, Hiroki Sakamoto, Masayuki Kitano, Masatoshi Kudo
The most common symptom in patients with advanced pancreatic cancer is abdominal pain. This has traditionally been treated with nonsteroidal anti-inflammatory drugs and opioid analgesics. However, these treatments result in inadequate pain control or drug-related adverse effects in some patients. An alternative pain-relief modality is celiac plexus neurolysis, in which the celiac plexus is chemically ablated. This procedure was performed percutaneously or intraoperatively until 1996, when endoscopic ultrasound (EUS)-guided celiac plexus neurolysis was first described...
February 15, 2018: Cancers
Shinji Kamisuki, Natsumi Himeno, Yukine Tsurukawa, Tomoe Kusayanagi, Masahiro Takeno, Takashi Kamakura, Kouji Kuramochi, Fumio Sugawara
Neoechinulin A is an indole alkaloid with several biological activities. We previously reported that this compound protects neuronal PC12 cells from cytotoxicity induced by the peroxynitrite generator 3-morpholinosydnonimine (SIN-1), but the target proteins and precise mechanism of action of neoechinulin A were unclear. Here, we employed a phage display screen to identify proteins that bind directly with neoechinulin A. Our findings identified two proteins, chromogranin B and glutaredoxin 3, as candidate target binding partners for the alkaloid...
February 15, 2018: Bioscience, Biotechnology, and Biochemistry
Atsushi Tsukamoto, Natsuko Niino, Mizuho Sakamoto, Risa Ohtani, Tomo Inomata
To achieve surgical anesthesia in animal experimentation, it is necessary to select the appropriate anesthetic protocol by considering its pharmacological properties and the surgical procedure to be performed. However, few studies have investigated the validity of anesthetic protocols under surgical conditions in small rodents. The present study aimed to clarify the pharmacological properties of 4 anesthetic protocols during the surgical procedure of castration in rats. Eight-week-old male Wistar rats were anesthetized with anesthetics, including the combination of ketamine and xylazine (K/X), the combination of medetomidine, midazolam, and butorphanol (M/M/B), and isoflurane, and sevoflurane...
February 14, 2018: Experimental Animals
Hiroaki Norimoto, Kenichi Makino, Mengxuan Gao, Yu Shikano, Kazuki Okamoto, Tomoe Ishikawa, Takuya Sasaki, Hiroyuki Hioki, Shigeyoshi Fujisawa, Yuji Ikegaya
The functions of sleep for synaptic plasticity remain elusive. We report that mouse hippocampal sharp wave/ripple oscillations serve as intrinsic events that trigger long-lasting synaptic depression. Silencing of sharp waves/ripples during slow-wave states prevented the spontaneous downregulation of net synaptic weights and impaired the learning of new memories. The synaptic downregulation was N -methyl-d-aspartate receptor-dependent and input pathway-selective. Thus, our findings are consistent with the role of slow-wave states in refining memory engrams by reducing recent memory-irrelevant neuronal activity and suggest a new role for sharp waves/ripples...
February 8, 2018: Science
John Gaitanis, Tomo Tarui
PURPOSE OF REVIEW: This article provides an overview of the most common nervous system malformations and serves as a reference for the latest advances in diagnosis and treatment. RECENT FINDINGS: Major advances have occurred in recognizing the genetic basis of nervous system malformations. Environmental causes of nervous system malformations, such as perinatal infections including Zika virus, are also reviewed. Treatment for nervous system malformations begins prior to birth with prevention...
February 2018: Continuum: Lifelong Learning in Neurology
Y Sawa, G Matsumiya, K Matsuda, E Tatsumi, T Abe, K Fukunaga, S Ichiba, A Kishida, K Kokubo, T Masuzawa, A Myoui, M Nishimura, T Nishimura, T Nishinaka, E Okamoto, S Tokunaga, T Tomo, T Tsukiya, Y Yagi, T Yamaoka
No abstract text is available yet for this article.
February 9, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
Yoko Tomo, Alexandros Askounis, Tatsuya Ikuta, Yasuyuki Takata, Khellil Sefiane, Koji Takahashi
Fluids confined in a nanoscale space behave differently than in the bulk due to strong interactions between fluid molecules and solid atoms. Here, we observed water confined inside "open" hydrophilized carbon nanotubes (CNT), with diameter of tens of nanometers, using transmission electron microscopy (TEM). A 1-7 nm water films adhering to most of the inner wall surface was observed and remained stable in the high vacuum (order of 10-5 Pa) of the TEM. The super-stability of this film was attributed to a combination of curvature, nano-roughness and confinement resulting in a lower vapor pressure for water and hence inhibiting its vaporization...
February 9, 2018: Nano Letters
Maria A van Agthoven, Alice M Lynch, Tomos E Morgan, Christopher A Wootton, Yuko P Y Lam, Lionel Chiron, Mark P Barrow, Marc-André Delsuc, Peter B O'Connor
Two-dimensional mass spectrometry (2D MS) correlates precursor and fragment ions without ion isolation in a Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) for tandem mass spectrometry. Infrared activated electron capture dissociation (IR-ECD), using a hollow cathode configuration, generally yields more information for peptide sequencing in tandem mass spectrometry than ECD (electron capture dissociation) alone. The effects of the fragmentation zone on the 2D mass spectrum are investigated, as well as the structural information that can be derived from it...
February 8, 2018: Analytical Chemistry
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