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https://www.readbyqxmd.com/read/28438878/surgical-management-of-non-small-cell-lung-cancer-with-solitary-hematogenous-metastases
#1
Grigorios Karagkiouzis, Eleftherios Spartalis, Demetrios Moris, Demetrios Patsouras, Athanasios Athanasiou, Ioannis Karathanasis, Alexios Verveniotis, Froso Konstantinou, Ilias A Kouerinis, Konstantinos Potaris, Dimitrios Dimitroulis, Periklis Tomos
BACKGROUND/AIM: The treatment of patients with solitary hematogenous metastases from non-small cell lung cancer (NSCLC) remains controversial, although numerous retrospective studies have reported favorable results for patients offered combined surgical therapy. Our aim was to determine the role of surgical resection in the management of NSCLC with solitary extrapulmonary metastases and to investigate for possible prognostic factors. PATIENTS AND METHODS: Between January 2004 and December 2012, 12 patients with NSCLC, from two Institutions, underwent metastasectomy for their solitary metastatic lesion...
May 2017: In Vivo
https://www.readbyqxmd.com/read/28434083/predictors-of-a-successful-outcome-for-infants-with-short-bowel-syndrome-a-30-year-single-institution-experience
#2
Tatsuru Kaji, Kazuhiko Nakame, Seiro Machigashira, Takafumi Kawano, Ryuta Masuya, Waka Yamada, Koji Yamada, Shun Onishi, Tomoe Moriguchi, Koshiro Sugita, Motoi Mukai, Satoshi Ieiri
PURPOSE: Short-bowel syndrome (SBS) is associated with high morbidity and mortality. We conducted this study to establish the predictors of survival and weaning off parenteral nutrition (PN). METHODS: We reviewed the medical records of 16 SBS infants treated at our institution within a 30-year period. SBS was defined as a residual small-bowel length (RSBL) of <75 cm. Loss of the ileocecal valve (ICV), cholestasis (D-Bil >2.0 mg/dl), enterostomy, and RSBL were all evaluated...
April 22, 2017: Surgery Today
https://www.readbyqxmd.com/read/28432910/total-mercury-levels-in-hair-of-children-aged-7years-before-and-after-the-great-east-japan-earthquake
#3
Nozomi Tatsuta, Kunihiko Nakai, Miyuki Iwai-Shimada, Tomoe Suzuki, Hiroshi Satoh, Katsuyuki Murata
The Great East Japan Earthquake on March 11, 2011 caused severe damage to the Sanriku coastal area, where we have been conducting a birth cohort study. The disaster occurred in the middle of 7-year-old examination. The mother-child pairs who participated in our study were compulsorily divided into two groups: the examination was finished for 157 children before the disaster, and for 335 after the disaster. We examined whether the disaster affected total mercury (THg) levels of the cohort, as well as a relationship between the THg levels at birth and at present...
April 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28429499/atrial-fibrillation-patients-with-isolated-pulmonary-veins-is-sinus-rhythm-achievable
#4
Judit Szilágyi, Gregory M Marcus, Nitish Badhwar, Byron K Lee, Randall J Lee, Vasanth Vedantham, Zian H Tseng, Tomos Walters, Melvin Scheinman, Jeffrey Olgin, Edward P Gerstenfeld
BACKGROUND: The cornerstone of atrial fibrillation (AF) ablation is isolation of the pulmonary veins (PVs). Patients with recurrent AF undergoing repeat ablation usually have PV reconnection (PVr). The ablation strategy and outcome of patients undergoing repeat ablation who have persistent isolation of all PVs (PVi) at the time of repeat ablation is unknown. METHODS AND RESULTS: We studied consecutive patients with recurrent AF undergoing repeat ablation and compared patients with PVi to those with PVr...
April 21, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28428518/-a-case-of-malignant-lymphoma-of-the-jejunum-that-developed-stenosis-and-perforation-after-a-complete-response-to-chemotherapy
#5
Atsushi Sugimoto, Masaharu Tada, Tomoe Taji, Yudai Houjo, Yu Kanokogi, Masaaki Hirata, Yusuke Fujita, Yusuke Kawasaki, Takashi Sakamoto, Junichi Yoshikawa, Hideaki Iwama, Shinichiro Usuki, Yoshiharu Shirakata, Jun Tamura, Atsuhiko Maki
A 57-year-old woman was admitted owing to epigastric pain.Abdominal computed tomography demonstrated a tumor in the origin of the jejunum.After an endoscopic biopsy, we diagnosed diffuse large B-cell lymphoma.We treated her with CHOP chemotherapy because pancreaticoduodenectomy is highly invasive.After 1 course of chemotherapy, the tumor was reduced.However, she developed a jejunal stenosis; therefore, we performed laparoscopic gastrojejunostomy.Furthermore, she developed perforated peritonitis on the sixth day after the surgery, and therefore, an emergency partial jejunum resection was performed...
April 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28428480/exposure-to-high-glucose-concentration-decreases-cell-surface-abca1-and-hdl-biogenesis-in-hepatocytes
#6
Maki Tsujita, Mohammad Anwar Hossain, Rui Lu, Tomoe Tsuboi, Kuniko Okumura-Noji, Shinji Yokoyama
AIM: To study atherosclerosis risk in diabetes, we investigated ATP-binding cassette transporter A1 (ABCA1) expression and high-density lipoprotein (HDL) biogenesis in the liver and hepatocytes under hyperglycemic conditions. METHODS AND RESULTS: In streptozotocin-induced diabetic mice, plasma HDL decreased while ABCA1 protein increased without changing its mRNA in the liver, only in the animals that responded to the treatment to show hypoinsulinemia and fasting hyperglycemia but not in the poor responders not showing those...
April 19, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28417567/a-versatile-and-simple-approach-to-generate-light-emission-in-semiconductors-mediated-by-electric-double-layers
#7
Jiang Pu, Taiyo Fujimoto, Yuki Ohasi, Shota Kimura, Chang-Hsiao Chen, Lain-Jong Li, Tomo Sakanoue, Taishi Takenobu
The light-emitting device is the primary device for current light sources. In principle, conventional light-emitting devices need heterostructures and/or intentional carrier doping to form a p-n junction. This junction formation is, however, very difficult to achieve for most emerging semiconductors, and the fabrication of light-emitting devices is invariably a significant challenge. This study proposes a versatile and simple approach to realize light-emitting devices. This proposed device requires only a semiconducting film with two electrodes that are covered with an electrolyte...
April 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28409058/exposure-to-h1-genotype-measles-virus-at-an-international-airport-in-japan-on-31-july-2016-results-in-a-measles-outbreak
#8
Aika Watanabe, Yusuke Kobayashi, Tomoe Shimada, Yuichiro Yahata, Ayako Kobayashi, Mizue Kanai, Yushi Hachisu, Munehisa Fukusumi, Hajime Kamiya, Takuri Takahashi, Yuzo Arima, Hitomi Kinoshita, Kazuhiko Kanou, Takehito Saitoh, Satoru Arai, Hiroshi Satoh, Hideo Okuno, Saeko Morino, Tamano Matsui, Tomimasa Sunagawa, Keiko Tanaka-Taya, Makoto Takeda, Katsuhiro Komase, Kazunori Oishi
No abstract text is available yet for this article.
January 2017: Western Pacific Surveillance and Response Journal: WPSAR
https://www.readbyqxmd.com/read/28408105/a-meta-analysis-of-effects-of-transcatheter-versus-surgical-aortic-valve-replacement-on-left-ventricular-ejection-fraction-and-mass
#9
Hisato Takagi, Tomo Ando, Takuya Umemoto
OBJECTIVES: To determine which procedure, transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR), for severe aortic stenosis (AS) improves follow-up left ventricular (LV) function or hypertrophy more effectively, we performed the first meta-analysis of comparative studies reporting LV ejection fraction (LVEF) or mass (LVM) after TAVI versus SAVR. METHODS: Studies considered for inclusion met the following criteria: the article was written in English; the design was a comparative study; the study population was patients with severe AS; patients were assigned to TAVI versus SAVR; and outcomes included follow-up (6-12-month) LVEF or LVM...
April 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28407803/orchitis-reveals-an-extragonadal-primary-mediastinal-thymic-seminoma-a-coincidence-or-not
#10
Athanasios Tampakis, Ekaterini Christina Tampaki, Christos Damaskos, Themistoklis Feretis, Irene Thymara, Konstantinos Kontzoglou, Periklis Tomos, Gregory Kouraklis
BACKGROUND: Mediastinal thymic seminomas are rare male germ cell tumors with extragonadal origin that appear predominately with a cystic appearance. CASE PRESENTATION: A 22-year-old male was referred to our department for further investigation of a mediastinal mass discovered incidentally during routine chest X-ray. The patient has denied any symptoms including dyspnea, chest pain, cough, fever, dysphagia, hemoptysis, weight loss, and weakness. His past medical history was remarkable for orchitis, for which he had undergone a bilateral testicular biopsy, without the latter however, indicating the presence of a germ cell tumor or a premalignant lesion...
April 13, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28407025/relationships-between-temperaments-occupational-stress-and-insomnia-among-japanese-workers
#11
Yasuhiko Deguchi, Shinichi Iwasaki, Hideyuki Ishimoto, Koichiro Ogawa, Yuichi Fukuda, Tomoko Nitta, Tomoe Mitake, Yukako Nogi, Koki Inoue
Insomnia among workers reduces the quality of life, contributes toward the economic burden of healthcare costs and losses in work performance. The relationship between occupational stress and insomnia has been reported in previous studies, but there has been little attention to temperament in occupational safety and health research. The aim of this study was to clarify the relationships between temperament, occupational stress, and insomnia. The subjects were 133 Japanese daytime local government employees...
2017: PloS One
https://www.readbyqxmd.com/read/28404615/myeloperoxidase-mediates-postischemic-arrhythmogenic-ventricular-remodeling
#12
Martin Mollenhauer, Kai Friedrichs, Max Lange, Jan Gesenberg, Lisa Remane, Christina Kerkenpaß, Jenny Krause, Johanna Schneider, Thorben Ravekes, Martina Maass, Marcel Halbach, Gabriel Peinkofer, Tomo Saric, Dennis Mehrkens, Matti Adam, Florian G Deuschl, Denise Lau, Birgit Geertz, Kashish Manchanda, Thomas Eschenhagen, Lukas Kubala, Tanja K Rudolph, Yuping Wu, Wh W Tang, Stanley L Hazen, Stephan Baldus, Anna Klinke, Volker Rudolph
Rationale: Ventricular arrhythmias remain the leading cause of death in patients suffering myocardial ischemia. Myeloperoxidase (MPO), a heme-enzyme released by polymorphonuclear neutrophils, accumulates within ischemic myocardium and has been linked to adverse left ventricular remodeling. Objective: To reveal the role of MPO for the development of ventricular arrhythmias. Methods and Results: In different murine models of myocardial ischemia MPO deficiency profoundly decreased vulnerability for ventricular tachycardia (VT) upon programmed right ventricular and burst stimulation and spontaneously as assessed by ECG telemetry following isoproterenol injection...
April 12, 2017: Circulation Research
https://www.readbyqxmd.com/read/28396976/preface-photosynthesis-and-hydrogen-energy-research-for-sustainability
#13
EDITORIAL
Tatsuya Tomo, Suleyman I Allakhverdiev
Energy supply, climate change, and global food security are among the main chalenges facing humanity in the twenty-first century. Despite global energy demand is continuing to increase, the availability of low cost energy is decreasing. Together with the urgent problem of climate change due to CO2 release from the combustion of fossil fuels, there is a strong requirement of developing the clean and renewable energy system for the hydrogen production. Solar fuel, biofuel, and hydrogen energy production gained unlimited possibility and feasibility due to understanding of the detailed photosynthetic system structures...
April 10, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28394008/large-thoracic-tumor-without-superior-vena-cava-syndrome
#14
Nikolaos Garmpis, Christos Damaskos, Nikolaos Patelis, Dimitrios Dimitroulis, Eleftherios Spartalis, Ioannis Tomos, Anna Garmpi, Michael Spartalis, Efstathios A Antoniou, Konstantinos Kontzoglou, Periklis Tomos
A 62 year-old male with long-standing smoking history presented with hemoptysis. Plain chest x-ray showed abnormal findings proximate to the right pulmonary hilum. Bronchoscopy revealed a fragile exophytic tumor of the right wall of the lower third of the trachea, infiltrating the right main bronchus (75% stenosis) and the right upper lobar bronchus (near total occlusion). Contrast-enhanced chest CT demonstrated a 7.2x4.9 cm tumor contiguous to the above-mentioned structures, mediastinal lymph node pathology, and a vessel coursing inferiorly to the left of the aortic arch and anterior to the left hilum...
April 10, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28392721/survival-analysis-more-than-meets-the-eye
#15
REVIEW
Marko Lucijanic, Marko Skelin, Tomo Lucijanic
The log-rank test is a cornerstone of phase III oncology clinical trials. However, there are at least three different mathematical procedures that can be named the log-rank test and two of them are widely used by commercial statistical programs. Consequently, different P values can be obtained. In the case of a borderline statistical significance, this can mean the difference between the evidence (significant P value) and merely an observation. Since all three methods can be reported under the same name, space for possible data manipulation occurs...
February 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28387317/transgenic-mouse-model-for-imaging-of-atf4-translational-activation-related-cellular-stress-responses-in-vivo
#16
Takao Iwawaki, Ryoko Akai, Takae Toyoshima, Naoki Takeda, Tomo-O Ishikawa, Ken-Ichi Yamamura
Activating transcription factor 4 (ATF4) is a translationally activated protein that plays a role in cellular adaptation to several stresses. Because these stresses are associated with various diseases, the translational control of ATF4 needs to be evaluated from the physiological and pathological points of view. We have developed a transgenic mouse model to monitor the translational activation of ATF4 in response to cellular stress. By using this mouse model, we were able to detect nutrient starvation response, antivirus response, endoplasmic reticulum (ER) stress response, and oxidative stress in vitro and ex vivo, as well as in vivo...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28381756/a-rare-case-of-biphasic-malignant-peritoneal-mesothelioma-with-refractory-ascites
#17
Tomo Komaki, Hidenori Urata, Ken Mori, Akinori Iwashita, Keisuke Ikeda, Seiji Haraoka
An 81-year-old man was admitted to our hospital with abdominal distension due to refractory ascites of unknown origin. He subsequently died of aspiration pneumonia. Autopsy revealed a diagnosis of biphasic malignant peritoneal mesothelioma (MPM) containing both epithelioid and sarcomatous components. The diagnosis of MPM is often difficult because serum tumor markers, imaging studies, and the cytology of ascites may not provide enough information. Accordingly, peritoneal biopsy is necessary in order to diagnose MPM based on the histological and immunohistochemical findings...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28379691/polypharmacology-approaches-against-the-pseudomonas-aeruginosa-mvfr-regulon-and-their-application-in-blocking-virulence-and-antibiotic-tolerance
#18
Damien Maura, Steffen L Drees, Arunava Bandyopadhaya, Tomoe Kitao, Michele Negri, Melissa Starkey, Biliana Lesic, Sylvain Milot, Eric Deziel, Robert Zahler, Mike Pucci, Antonio Felici, Susanne Fetzner, Francois Lepine, Laurence G Rahme
Pseudomonas aeruginosa is an important nosocomial pathogen that is frequently recalcitrant to available antibiotics, underlining the urgent need for alternative therapeutic options against this pathogen. Targeting virulence functions is a promising alternative strategy as it is expected to generate less selective resistance to treatment compared to antibiotics. Capitalizing on our non-ligand based benzamide - benzimidazole (BB) core structure compounds reported to efficiently block the activity of the P. aeruginosa multiple virulence factor regulator MvfR, here we report the first class of inhibitors shown to interfere with PqsBC enzyme activity, responsible for the synthesis of the MvfR activating ligands HHQ and PQS, and the first to target simultaneously MvfR and PqsBC activity...
April 5, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28377632/integrated-analysis-of-gene-expression-and-copy-number-identified-potential-cancer-driver-genes-with-amplification-dependent-overexpression-in-1-454-solid-tumors
#19
Keiichi Ohshima, Keiichi Hatakeyama, Takeshi Nagashima, Yuko Watanabe, Kaori Kanto, Yuki Doi, Tomomi Ide, Yuji Shimoda, Tomoe Tanabe, Sumiko Ohnami, Shumpei Ohnami, Masakuni Serizawa, Koji Maruyama, Yasuto Akiyama, Kenichi Urakami, Masatoshi Kusuhara, Tohru Mochizuki, Ken Yamaguchi
Identification of driver genes contributes to the understanding of cancer etiology and is imperative for the development of individualized therapies. Gene amplification is a major event in oncogenesis. Driver genes with tumor-specific amplification-dependent overexpression can be therapeutic targets. In this study, we aimed to identify amplification-dependent driver genes in 1,454 solid tumors, across more than 15 cancer types, by integrative analysis of gene expression and copy number. Amplification-dependent overexpression of 64 known driver oncogenes were found in 587 tumors (40%); genes frequently observed were MYC (25%) and MET (18%) in colorectal cancer; SKP2 (21%) in lung squamous cell carcinoma; HIST1H3B (19%) and MYCN (13%) in liver cancer; KIT (57%) in gastrointestinal stromal tumors; and FOXL2 (12%) in squamous cell carcinoma across tissues...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28368720/a-nationwide-multicenter-study-of-the-cochlin-tomo-protein-detection-test-clinical-characteristics-of-perilymphatic-fistula-cases
#20
Han Matsuda, Kei Sakamoto, Tomohiro Matsumura, Shiho Saito, Susumu Shindo, Kunihiro Fukushima, Shin-Ya Nishio, Ryosuke Kitoh, Osamu Shibasaki, Akinori Ito, Ryuichiro Araki, Shin-Ichi Usami, Mamoru Suzuki, Kaoru Ogawa, Tomonori Hasegawa, Yoshiaki Hagiwara, Yasuhiro Kase, Tetsuo Ikezono
OBJECTIVE: To investigate the positive rate for the Cochlin tomo-protein (CTP: an inner ear-specific protein) detection test among patients with inner ear-related clinical manifestations and evaluate the clinical characteristics of definite perilymphatic fistula (PLF). METHODS: We have performed an ELISA-based CTP detection test using middle ear lavage (MEL) samples from 497 cases of suspected PLF enrolled from 70 clinical centers nationwide between 2014 and 2015...
April 3, 2017: Acta Oto-laryngologica
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