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https://www.readbyqxmd.com/read/29145721/meta-analysis-of-day-of-week-variation-of-acute-aortic-rupture-or-dissection
#1
Hisato Takagi, Tomo Ando, Shohei Mitta, Takuya Umemoto
BACKGROUND: We performed a meta-analysis to assess the presence of a day-of-week rhythmic variability of acute aortic rupture or dissection (AARD) onset. METHODS: Eligible studies were observational studies enrolling patients with AARD and reporting day-of-week variation of AARD. Study-specific estimates, i.e. day-of-week incidence of AARD, were combined using the random-effects model. Chronobiological analysis was performed by applying a partial Fourier series to pooled day-of-week incidence by using the inverse-variance weighted least-squares method...
November 16, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29138391/maternal-impulse-control-disability-and-developmental-disorder-traits-are-risk-factors-for-child-maltreatment
#2
Yoshiyuki Tachibana, Kenji Takehara, Naoko Kakee, Masashi Mikami, Eisuke Inoue, Rintaro Mori, Erika Ota, Tomoe Koizumi, Makiko Okuyama, Takahiko Kubo
Previous work has suggested that maternal developmental disorder traits related to autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are significantly associated with child maltreatment. However, there may be other important maternal characteristics that contribute to child maltreatment. We hypothesized that maternal impulse control disability may also affect child maltreatment in addition to maternal developmental disorder traits. We aimed to test this hypothesis via a cohort study performed in Tokyo (n = 1,260)...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29136001/a-combination-intervention-strategy-to-improve-linkage-to-and-retention-in-hiv-care-following-diagnosis-in-mozambique-a-cluster-randomized-study
#3
Batya Elul, Matthew R Lamb, Maria Lahuerta, Fatima Abacassamo, Laurence Ahoua, Stephanie A Kujawski, Maria Tomo, Ilesh Jani
BACKGROUND: Concerning gaps in the HIV care continuum compromise individual and population health. We evaluated a combination intervention strategy (CIS) targeting prevalent barriers to timely linkage and sustained retention in HIV care in Mozambique. METHODS AND FINDINGS: In this cluster-randomized trial, 10 primary health facilities in the city of Maputo and Inhambane Province were randomly assigned to provide the CIS or the standard of care (SOC). The CIS included point-of-care CD4 testing at the time of diagnosis, accelerated ART initiation, and short message service (SMS) health messages and appointment reminders...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29133340/effects-of-hawthorn-crataegus-pentagyna-leaf-extract-on-electrophysiologic-properties-of-cardiomyocytes-derived-from-human-cardiac-arrhythmia-specific-induced-pluripotent-stem-cells
#4
Sara Pahlavan, Marziyeh Shalchi Tousi, Mahdi Ayyari, Abolfazl Alirezalu, Hassan Ansari, Tomo Saric, Hossein Baharvand
Cardiac arrhythmias are major life-threatening conditions. The landmark discovery of induced pluripotent stem cells has provided a promising in vitro system for modeling hereditary cardiac arrhythmias as well as drug development and toxicity testing. Nowadays, nutraceuticals are frequently used as supplements for cardiovascular therapy. Here we studied the cardiac effects of hawthorn (Crataegus pentagyna) leaf extract using cardiomyocytes (CMs) differentiated from healthy human embryonic stem cells, long QT syndrome type 2 (LQTS2), and catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) patient-specific induced pluripotent stem cells...
November 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29131412/oxidation-of-polynuclear-aromatic-hydrocarbons-using-ruthenium-ion-catalyzed-oxidation-the-role-of-aromatic-ring-number-in-reaction-kinetics-and-product-distribution
#5
Stuart H Taylor, Ewa Nowicka, Tomos Clarke, Meenakshisundaram Sankar, Robert Jenkins, David Knight, Stanislaw Golunski, Graham Hutchings, David Willock, Manuel Francisco
Oxidation of aromatic hydrocarbons with differing numbers of fused aromatic rings (2-5), have been studied in two solvents environments (monophasic and biphasic) using ruthenium ion catalyzed oxidation (RICO). RICO reduces the aromaticity of the polyaromatic core of the molecule in a controlled manner by selective oxidative ring opening. Moreover, the nature of the solvent system determines the product type and distribution, for molecules with more than 2 aromatic rings. Competitive oxidation between substrates with different numbers of aromatic rings has been studied in detail...
November 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29129887/-analysis-of-backgrounds-and-level-of-understanding-of-treatment-of-poor-adherence-and-dropout-cases-on-sublingual-immunotherapy-for-japanese-cedar-pollinosis-in-the-first-follow-up-year
#6
Sayaka Kikkawa, Atsushi Kamijo, Kazuyuki Nakagome, Tomoyuki Soma, Takehito Kobayashi, Yoshitaka Uchida, Eiji Morita, Makoto Nagata, Tomoe Inoue, Yasuhiro Kase
BACKGROUND: We considered the factors of poor adherence to and dropout from sublingual immunotherapy (SLIT) by verifying patient backgrounds 1 year after start of treatment. METHODS: We recruited 38 patients who began SLIT between November 2014 and September 2015. We analyzed their attributes and level of understanding of the treatment, and conducted a self-reported survey on factors behind dropout cases and poor adherence cases. RESULTS: Four patients dropped out 1 year after start of treatment...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29117496/coronary-artery-aneurysm-in-tocilizumab-treated-children-with-kawasaki-s-disease
#7
LETTER
Tomo Nozawa, Tomoyuki Imagawa, Shuichi Ito
New England Journal of Medicine, Volume 377, Issue 19, Page 1894-1896, November 2017.
November 9, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29110406/switching-from-low-dose-thiazide-diuretics-to-sglt2-inhibitor-improves-various-metabolic-parameters-without-affecting-blood-pressure-in-subjects-with-type-2-diabetes-and-hypertension
#8
Tomohiko Kimura, Junpei Sanada, Masashi Shimoda, Hidenori Hirukawa, Yoshiro Fushimi, Momoyo Nishioka, Tomoe Kinoshita, Seizo Okauchi, Atsushi Obata, Kenji Kohara, Fuminori Tatsumi, Shinji Kamei, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
AIM/INTRODUCTION: Sodium-glucose co-transporter 2 (SGLT2) inhibitors function to increase urinary glucose excretion and improve glycemic control in subjects with type 2 diabetes mellitus. SGLT2 inhibitors as well as diuretics increase urinary volume which leads to the reduction of blood pressure. The aim of this study was to compare the effects of SGLT2 inhibitor and thiazide diuretic on blood pressure, metabolic parameters and body mass composition. MATERIALS AND METHODS: A total of 31 subjects were enrolled in this study...
November 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29109853/mesenteric-vein-thrombosis-following-impregnation-via-in-vitro-fertilization-embryo-transfer
#9
Masaaki Hirata, Hiroko Yano, Tomoe Taji, Yoshiharu Shirakata
Pregnancy is an acquired hypercoagulable state. Most patients with thrombosis that develops during pregnancy present with deep vein leg thrombosis and/or pulmonary embolism, whereas the development of mesenteric vein thrombosis (MVT) in pregnant patients is rare. We report a case of MVT in a 34-year-old woman who had achieved pregnancy via in vitro fertilization-embryo transfer (IVF-ET). At 7 wk of gestation, the patient was referred to us due to abdominal pain accompanied by vomiting and hematochezia, and she was diagnosed with superior MVT...
October 27, 2017: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29108327/evaluation-of-the-branched-chain-amino-acid-to-tyrosine-ratio-prior-to-treatment-as-a-prognostic-predictor-in-patients-with-liver-cirrhosis
#10
Toru Ishikawa, Michitaka Imai, Masayoshi Ko, Hiroki Sato, Yujiro Nozawa, Tomoe Sano, Akito Iwanaga, Keiichi Seki, Terasu Honma, Toshiaki Yoshida
This study evaluated whether the branched-chain amino acid-to-tyrosine ratio (BTR) is a prognostic predictive factor in patients with liver cirrhosis by determining the relationship of the BTR with event-free survival in a retrospective, observational cohort study. The medical records of patients with liver cirrhosis who visited our institution from February 2000 to May 2012 were examined. Events due to liver cirrhosis were defined as death, worsening of esophageal and/or gastric varices, hepatocellular carcinoma, and liver failure...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29094400/editorial-comment-to-does-the-suburethral-sling-change-its-location
#11
Hikaru Tomoe
No abstract text is available yet for this article.
November 1, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29093491/dosimetric-comparison-of-the-helical-tomotherapy-volumetric-modulated-arc-therapy-and-fixed-field-intensity-modulated-radiotherapy-for-stage-iib-iiib-non-small-cell-lung-cancer
#12
Yujin Xu, Weiye Deng, Shuangyan Yang, Pu Li, Yue Kong, Ye Tian, Zhongxing Liao, Ming Chen
The study aimed to compare the dosimetric parameters to target dose coverage and the critical structures in the treatment planning of helical tomotherapy (TOMO), volumetric-modulated arc therapy (VMAT), and fixed-field intensity-modulated radiotherapy (IMRT) for NSCLC delivering conventionally fractionated radiotherapy. Thirty patients with pathologically confirmed NSCLC were included. Three radiation treatment plans were designed for each patient. All patients received the uniform prescription dose of 60 Gy to the planning target volume...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29093395/near-tetraploidy-acute-myeloid-leukemia-in-long-term-remission-with-persistent-clonal-hematopoiesis-with-del-20-q12q13
#13
Tohru Takahashi, Kazuya Ishiguro, Yumiko Maruyama, Tomoe Kazama, Takenori Takamura, Hideto Itoh, Mitsuru Yoshimoto, Masayuki Tsujisaki, Go Ohba
Patients with near tetraploidy/tetraploidy (NT/T)-acute myeloid leukemia (AML) are rare and generally show poor survival. A 62-year-old man was referred to our hospital with pancytopenia. A bone marrow examination revealed the proliferation of extremely large blasts, and led to the diagnosis of AML M0. A cytogenetic analysis showed an NT-karyotype of 91, XXYY, -5, add(18)(p21),del(20)(q12q13) ×2. Complete remission was achieved with single remission induction chemotherapy. Although consolidation chemotherapies were not available because of his critical condition, he remained in remission and survived for more than 40 months without cytopenia...
November 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29077729/modulation-of-benzylisoquinoline-alkaloid-biosynthesis-by-heterologous-expression-of-cjwrky1-in-eschscholzia-californica-cells
#14
Yasuyuki Yamada, Tomoe Shimada, Yukiya Motomura, Fumihiko Sato
Transcription factors control many processes in plants and have high potentials to manipulate specialized metabolic pathways. Transcriptional regulation of the biosynthesis of monoterpenoid indole alkaloids (MIAs), nicotine alkaloids, and benzylisoquinoline alkaloids (BIAs) has been characterized using Catharanthus roseus, Nicotiana and Coptis plants. However, metabolic engineering in which specific transcription factors are used in alkaloid biosynthesis is limited. In this study, we characterized the effects of ectopic expression of CjWRKY1, which is a transcriptional activator with many targets in BIA biosynthesis in Coptis japonica (Ranunculaceae) and Eschscholzia californica (California poppy, Papaveraceae)...
2017: PloS One
https://www.readbyqxmd.com/read/29064136/pyridoxamine-a-novel-treatment-for-schizophrenia-with-enhanced-carbonyl-stress
#15
Masanari Itokawa, Mitsuhiro Miyashita, Makoto Arai, Takashi Dan, Katsuyoshi Takahashi, Taro Tokunaga, Kayo Ishimoto, Kazuya Toriumi, Tomoe Ichikawa, Yasue Horiuchi, Akiko Kobori, Satoshi Usami, Takeo Yoshikawa, Naoji Amano, Shinsuke Washizuka, Yuji Okazaki, Toshio Miyata
AIM: The aim of this clinical trial was to obtain proof of concept for high-dose pyridoxamine as a novel treatment for schizophrenia with enhanced carbonyl stress. METHODS: Ten Japanese schizophrenia patients with high plasma pentosidine, which is a representative biomarker of enhanced carbonyl stress, were recruited in a 24 week, open trial in which high-dose pyridoxamine (ranging from 1200 to 2400 mg/day) was administered using a conventional anti-psychotic regimen...
October 24, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29056799/technological-response-of-wild-macaques-macaca-fascicularis-to-anthropogenic-change
#16
Lydia V Luncz, Magdalena S Svensson, Michael Haslam, Suchinda Malaivijitnond, Tomos Proffitt, Michael Gumert
Anthropogenic disturbances have a detrimental impact on the natural world; the vast expansion of palm oil monocultures is one of the most significant agricultural influences. Primates worldwide consequently have been affected by the loss of their natural ecosystems. Long-tailed macaques (Macaca fascilularis) in Southern Thailand have, however, learned to exploit oil palm nuts using stone tools. Using camera traps, we captured the stone tool behavior of one macaque group in Ao Phang-Nga National Park. Line transects placed throughout an abandoned oil palm plantation confirmed a high abundance of nut cracking sites...
2017: International Journal of Primatology
https://www.readbyqxmd.com/read/29041586/high-power-and-highly-efficient-composite-laser-with-an-anti-reflection-coated-layer-between-a-laser-crystal-and-a-diamond-heat-spreader-fabricated-by-room-temperature-bonding
#17
Hiromasa Ichikawa, Kohki Yamaguchi, Tomo Katsumata, Ichiro Shoji
We have succeeded in bonding a Nd:YAG crystal and an anti-reflection coated diamond crystal to realize a composite laser which minimizes the Fresnel-reflection loss at the bonded interface for the first time. This newly developed composite laser has realized higher output power at higher pump power than a non-composite Nd:YAG laser while keeping nearly the same slope efficiency.
September 18, 2017: Optics Express
https://www.readbyqxmd.com/read/29040993/hemodynamic-changes-on-cone-beam-computed-tomography-during-balloon-occluded-transcatheter-arterial-chemoembolization-using-miriplatin-for-hepatocellular-carcinoma-a-preliminary-study
#18
Toru Ishikawa, Michitaka Imai, Takashi Owaki, Hiroki Sato, Yujiro Nozawa, Tomoe Sano, Akito Iwanaga, Keiichi Seki, Terasu Honma, Toshiaki Yoshida, Masatoshi Kudo
BACKGROUND/AIM: Balloon-occluded transcatheter arterial chemoembolization (B-TACE) using miriplatin (MPT) is anticipated as a new strategy for hepatocellular carcinoma (HCC). This study was aimed at evaluating the hemodynamic changes with/without balloon occlusion of the hepatic artery, correlation of cone-beam CT (CBCT) pixels, and CT value after B-TACE for HCC. METHODS: A total of 52 patients with HCC, who underwent B-TACE using MPT in addition to the balloon-occluded CBCT hepatic arteriography, were studied...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29033427/a-case-of-igg4-related-lung-pseudotumor-and-pleural-inflammation-with-autoimmune-hepatitis
#19
Kazunori Nagashima, Itsuki Sano, Tomoe Kobayashi, Kazunori Eto, Kosuke Nagai, Ryusuke Ninomiya, Akira Suzuki, Yoshihiro Oohata, Kouhei Konishi, Tsuyoshi Nakano, Fumiyasu Yamamoto
A 63-year-old man was admitted to our department following a secondary medical examination. Blood tests showed high levels of liver enzymes, IgG, IgG4, and antinuclear antibody. Computed tomography showed tumors in the bilateral lower lobes of the lungs and pleural thickening. After pleural and liver biopsy procedures, he was conclusively diagnosed with IgG4-related lung pseudotumor and pleural inflammation with autoimmune hepatitis. We started treatment with prednisolone 40 mg/day, and chest X-rays and blood tests showed signs of improvement...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29031998/dominant-foot-could-affect-the-postural-control-in-vestibular-neuritis-perceived-by-dynamic-body-balance
#20
Tomoe Yoshida, Toshitake Tanaka, Yuya Tamura, Masahiko Yamamoto, Mitsuya Suzuki
During attacks of vestibular neuritis (VN), patients typically lose postural balance, with resultant postural inclination, gait deviation toward the lesion side, and tendency to fall. In this study, we examined and analyzed static and dynamic postural control during attacks of VN to characterize differences in postural control between right and left VN. Subjects were patients diagnosed with VN at the Department of Otolaryngology, Toho University Sakura Medical Center, and underwent in-patient treatment. Twenty-five patients who had spontaneous nystagmus were assessed within 3days after the onset; all were right-foot dominant...
October 4, 2017: Gait & Posture
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