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https://www.readbyqxmd.com/read/28345311/relationships-among-sense-of-coherence-oral-health-status-nutritional-status-and-care-need-level-of-older-adults-according-to-path-analysis
#1
Nanae Dewake, Tomoko Hamasaki, Rie Sakai, Shima Yamada, Yuko Nima, Miki Tomoe, Satoko Kakuta, Masanori Iwasaki, Inho Soh, Yoshihiro Shimazaki, Toshihiro Ansai
AIM: Sense of coherence (SOC) is a measurement of ability of an individual to cope with psychological stress and remain in good health. The aim of the present study was to examine the relationships among SOC score, oral health status, nutritional status and care need level of older adults using path analysis. METHODS: We enrolled 53 older adults (17 men and 36 women) who were attending a day care service (mean age 80.4 ± 6.5 years). SOC was assessed using a 13-item, seven-scale instrument...
March 27, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28342444/acid-ceramidase-deficiency-in-mice-results-in-a-broad-range-of-central-nervous-system-abnormalities
#2
Jakub Sikora, Shaalee Dworski, E Ellen Jones, Mustafa A Kamani, Matthew C Micsenyi, Tomo Sawada, Pauline Le Faouder, Justine Bertrand-Michel, Aude Dupuy, Christopher K Dunn, Ingrid Cong Yang Xuan, Josefina Casas, Gemma Fabrias, David R Hampson, Thierry Levade, Richard R Drake, Jeffrey A Medin, Steven U Walkley
Farber disease is a rare autosomal recessive disorder caused by acid ceramidase deficiency that usually presents as early-onset progressive visceral and neurologic disease. To understand the neurologic abnormality, we investigated behavioral, biochemical, and cellular abnormalities in the central nervous system of Asah1(P361R/P361R) mice, which serve as a model of Farber disease. Behaviorally, the mutant mice had reduced voluntary locomotion and exploration, increased thigmotaxis, abnormal spectra of basic behavioral activities, impaired muscle grip strength, and defects in motor coordination...
April 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28334554/rapid-establishment-of-the-european-bank-for-induced-pluripotent-stem-cells-ebisc-the-hot-start-experience
#3
Paul A De Sousa, Rachel Steeg, Elisabeth Wachter, Kevin Bruce, Jason King, Marieke Hoeve, Shalinee Khadun, George McConnachie, Julie Holder, Andreas Kurtz, Stefanie Seltmann, Johannes Dewender, Sascha Reimann, Glyn Stacey, Orla O'Shea, Charlotte Chapman, Lyn Healy, Heiko Zimmermann, Bryan Bolton, Trisha Rawat, Isobel Atkin, Anna Veiga, Bernd Kuebler, Blanca Miranda Serano, Tomo Saric, Jürgen Hescheler, Oliver Brüstle, Michael Peitz, Cornelia Thiele, Niels Geijsen, Bjørn Holst, Christian Clausen, Majlinda Lako, Lyle Armstrong, Shailesh K Gupta, Alexander J Kvist, Ryan Hicks, Anna Jonebring, Gabriella Brolén, Andreas Ebneth, Alfredo Cabrera-Socorro, Patrik Foerch, Martine Geraerts, Tina C Stummann, Shawn Harmon, Carol George, Ian Streeter, Laura Clarke, Helen Parkinson, Peter W Harrison, Adam Faulconbridge, Luca Cherubin, Tony Burdett, Cesar Trigueros, Minal J Patel, Christa Lucas, Barry Hardy, Rok Predan, Joh Dokler, Maja Brajnik, Oliver Keminer, Ole Pless, Philip Gribbon, Carsten Claussen, Annette Ringwald, Beate Kreisel, Aidan Courtney, Timothy E Allsopp
A fast track "Hot Start" process was implemented to launch the European Bank for Induced Pluripotent Stem Cells (EBiSC) to provide early release of a range of established control and disease linked human induced pluripotent stem cell (hiPSC) lines. Established practice amongst consortium members was surveyed to arrive at harmonised and publically accessible Standard Operations Procedures (SOPs) for tissue procurement, bio-sample tracking, iPSC expansion, cryopreservation, qualification and distribution to the research community...
March 7, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28331131/the-aggressive-clinical-courses-of-hodgkin-lymphoma-primarily-diagnosed-as-methotrexate-induced-non-specific-lymphoproliferative-disorder-in-patients-with-rheumatoid-arthritis
#4
Michihide Tokuhira, Takayuki Tabayashi, Yuka Tanaka, Yasuyuki Takahashi, Yuta Kimura, Tatsuki Tomikawa, Tomoe Anan-Nemoto, Shuju Momose, Morihiro Higashi, Ayumi Okuyama, Reiko Watanabe, Koichi Amano, Jun-Ichi Tamaru, Masahiro Kizaki
Recently, attention has been focused on methotrexate-induced lymphoproliferative disease (MTX-LPD), and atypical phenotypes are occasionally documented. We encountered two patients with rheumatoid arthritis (RA) who were diagnosed with non-specific LPD (LPD-nos). Biopsy samples were not obtained during the initial examination when the LPD development was discovered, and the patients achieved a complete response after MTX cessation (case 1) or steroid pulse therapy (case 2). However, the tumors flared up 1.5 years later, and LPD-nos was determined following biopsies of the lymph node (LN, case 1) and liver (case 2)...
2017: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/28325763/pseudomonas-aeruginosa-alginate-overproduction-promotes-coexistence-with-staphylococcus-aureus-in-a-model-of-cystic-fibrosis-respiratory-infection
#5
Dominique H Limoli, Gregory B Whitfield, Tomoe Kitao, Melissa L Ivey, Michael R Davis, Nora Grahl, Deborah A Hogan, Laurence G Rahme, P Lynne Howell, George A O'Toole, Joanna B Goldberg
While complex intra- and interspecies microbial community dynamics are apparent during chronic infections and likely alter patient health outcomes, our understanding of these interactions is currently limited. For example, Pseudomonas aeruginosa and Staphylococcus aureus are often found to coinfect the lungs of patients with cystic fibrosis (CF), yet these organisms compete under laboratory conditions. Recent observations that coinfection correlates with decreased health outcomes necessitate we develop a greater understanding of these interbacterial interactions...
March 21, 2017: MBio
https://www.readbyqxmd.com/read/28321011/vehicle-dependent-effects-of-sphingosine-1-phosphate-on-plasminogen-activator-inhibitor-1-expression
#6
Chiharu Takahashi, Makoto Kurano, Masako Nishikawa, Kuniyuki Kano, Tomotaka Dohi, Katsumi Miyauchi, Hiroyuki Daida, Tomo Shimizu, Junken Aoki, Yutaka Yatomi
AIM: Sphingosine 1-phosphate (S1P) has been suggested to be a positive regulator of plasminogen activator inhibitor 1 (PAI-1) in adipocytes, while some studies are not consistent with this prothrombotic property of S1P. Since S1P is bound to apolipoprotein M (apoM) on HDL or to albumin in plasma, we compared the properties of these two forms on the PAI-1 induction. METHODS: We investigated the associations of S1P, apoM, and PAI-1 concentrations in the plasma of normal coronary artery (NCA), stable angina pectoris (SAP), and acute coronary syndrome (ACS) subjects (n=32, 71, and 38, respectively)...
March 17, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28320988/characterization-of-shiga-toxin-producing-escherichia-coli-from-feces-of-sika-deer-cervus-nippon-in-japan-using-pcr-binary-typing-analysis-to-evaluate-their-potential-human-pathogenicity
#7
Hidenori Kabeya, Shingo Sato, Shinya Oda, Megumi Kawamura, Mariko Nagasaka, Masanari Kuranaga, Eiji Yokoyama, Shinichiro Hirai, Atsushi Iguchi, Tomoe Ishihara, Toshiro Kuroki, Tomoko Morita-Ishihara, Sunao Iyoda, Jun Terajima, Makoto Ohnishi, Soichi Maruyama
This study examined the potential pathogenicity of Shiga toxin-producing Escherichia coli (STEC) in feces of sika deer by PCR binary typing (P-BIT), using 24 selected STEC genes. A total of 31 STEC strains derived from sika deer in 6 prefectures of Japan were O-serotyped and found to be O93 (n=12), O146 (n=5), O176 (n=3), O130 (n=3), O5 (n=2), O7 (n=1), O96 (n=1), O116 (n=1), O141 (n=1), O157 (n=1) and O-untypable (n=1). Of the 31 STEC strains, 13 carried both stx1 and stx2, 5 carried only stx1, and 13 carried one or two variants of stx2...
March 18, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28317733/antioxidant-activities-and-structural-characterization-of-flavonol-o-glycosides-from-seeds-of-japanese-horse-chestnut-aesculus-turbinata-blume
#8
Hideto Kimura, Satoshi Ogawa, Tomoe Ishihara, Mahoko Maruoka, Shota Tokuyama-Nakai, Mitsuo Jisaka, Kazushige Yokota
We attempted to evaluate the contents and distribution of antioxidants in the whole seeds, seed shells, and peeled seeds of the Japanese horse chestnut. The seed shells exhibited the highest antioxidant activities due to the presence of highly polymeric proanthocyanidins as we have reported recently. On the other hand, the peeled seeds predominantly contained flavonols such as quercetin and kaempferol at a high level of 66.7% of total polyphenols, also contributing to the predominant antioxidant activities...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28289598/massive-hemoptysis-in-a-patient-with-pulmonary-embolism-a-real-therapeutic-conundrum
#9
Yiolanda Herodotou, Andriana I Papaioannou, Anna Karakatsani, Lazaros Reppas, Effrosyni D Manali, Vasiliki Apollonatou, Ioannis Tomos, Elias Brountzos, Spyros Papiris
Massive Hemoptysis and pulmonary embolism are two very severe and potentially fatal pulmonary emergencies requiring completely different treatments. We present the case of a 45-year old male transmitted to our Hospital for massive hemoptysis who at the same time was found to suffer from pulmonary embolism. Hemoptysis was treated with bronchial artery embolization which resulted in cessation of haemorrhage and allowed the administration of anticoagulant therapy a few days later. This case report gives an answer on how to manage a real therapeutic conundrum which is the coexistence of a massive hemoptysis and a concomitant pulmonary embolism...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28288961/feasibility-of-rapid-linear-endocardial-and-epicardial-ventricular-ablation-using-an-irrigated-multipolar-radiofrequency-ablation-catheter
#10
Babak Nazer, Tomos E Walters, Srikant Duggirala, Edward P Gerstenfeld
BACKGROUND: A common strategy for ablation of scar-based ventricular tachycardia is delivering multiple lesions in a linear pattern. METHODS AND RESULTS: We tested the efficacy of a novel linear irrigated multipolar ablation catheter capable of creating linear lesions with a single application. Healthy swine underwent endocardial and epicardial linear ablation using a novel linear irrigated ablation catheter; control animals underwent focal lesions in a linear pattern over 3...
March 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28283089/e-coli-mismatch-repair-enhances-at-to-gc-mutagenesis-caused-by-alkylating-agents
#11
Kota Nakano, Yoko Yamada, Eizo Takahashi, Sakae Arimoto, Keinosuke Okamoto, Kazuo Negishi, Tomoe Negishi
Alkylating agents are known to induce the formation of O(6)-alkylguanine (O(6)-alkG) and O(4)-alkylthymine (O(4)-alkT) in DNA. These lesions have been widely investigated as major sources of mutations. We previously showed that mismatch repair (MMR) facilitates the suppression of GC-to-AT mutations caused by O(6)-methylguanine more efficiently than the suppression of GC-to-AT mutations caused by O(6)-ethylguanine. However, the manner by which O(4)-alkyT lesions are repaired remains unclear. In the present study, we investigated the repair pathway involved in the repair of O(4)-alkT...
March 2017: Mutation Research
https://www.readbyqxmd.com/read/28281996/odontogenic-infection-complicated-by-acute-descending-mediastinitis-and-pericardial-effusion-a-life-threatening-migration-path
#12
Eleftherios Spartalis, Andreas S Triantafyllis, Antonios Athanasiou, Demetrios Moris, Dimitrios Patsouras, Theodore Troupis, Dimitrios Dimitroulis, Periklis Tomos
No abstract text is available yet for this article.
February 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28280836/hydricity-electrochemistry-and-excited-state-chemistry-of-ir-complexes-for-co2-reduction
#13
Gerald F Manbeck, Komal Garg, Tomoe Shimoda, David J Szalda, Mehmed Z Ertem, James T Muckerman, Etsuko Fujita
We prepared electron-rich derivatives of [Ir(tpy)(ppy)Cl](+) with modification of the bidentate (ppy) or tridentate (tpy) ligands in an attempt to increase the reactivity for CO2 reduction and the ability to transfer hydrides (hydricity). Density functional theory (DFT) calculations reveal that complexes with dimethyl-substituted ppy have similar hydricities to the non-substituted parent complex, and photocatalytic CO2 reduction studies show selective CO formation. Substitution of tpy by bis(benzimidazole)-phenyl or -pyridine (L3 and L4, respectively) induces changes in the physical properties that are much more pronounced than from the addition of methyl groups to ppy...
March 10, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28279286/a-63-year-old-woman-with-progressive-dyspnea-after-remission-of-lymphoma
#14
Tomoe Nishihara, Hiroshi Nakano, Hiroko Nogami, Katsuyuki Katahira, Akiko Ishimatsu, Naozumi Hashimoto, Toyoharu Yokoi, Tomoaki Iwanaga
A 63-year-old woman visited our hospital for a further evaluation of progressive dyspnea. She had developed a progressive airflow obstruction after 3 years' remission of non-Hodgkin's lymphoma (follicular mixed cell type), which had been treated with chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). The patient's primary care physician had diagnosed her as having COPD and bronchial asthma and had treated her with medications including inhaled corticosteroids, tiotropium, and oral erythromycin...
March 2017: Chest
https://www.readbyqxmd.com/read/28274188/extracellular-matrix-remodeling-in-idiopathic-pulmonary-fibrosis-it-is-the-bed-that-counts-and-not-the-sleepers
#15
Ioannis P Tomos, Argyrios Tzouvelekis, Vassilis Aidinis, Effrosyni D Manali, Evangelos Bouros, Demosthenes Bouros, Spyros A Papiris
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by irreversible fibrosis. Current disease pathogenesis assumes an aberrant wound healing process in response to repetitive injurious stimuli leading to apoptosis of epithelial cells, activation of fibroblasts and accumulation of extracellular matrix (ECM). Particularly, lung ECM is a highly dynamic structure that lies at the core of several physiological and developmental pathways. The scope of this review article is to summarize current knowledge on the role of ECM in the pathogenesis of IPF, unravel novel mechanistic data and identify future more effective therapeutic targets...
March 8, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28263046/seizures-associated-with-tranexamic-acid-for-cardiac-surgery-a-meta-analysis-of-randomized-and-non-randomized-studies
#16
Hisato Takagi, Tomo Ando, Takuya Umemoto
BACKGROUND: We focused whether tranexamic acid (TXA) therapy for adult cardiac surgery is associated with an increase in the risk of seizures and performed a meta-analysis of randomized controlled trials (RCTs) and non-randomized observational studies. METHODS: MEDLINE and EMBASE were searched through December 2016 using PubMed and OVID. Eligible studies were RCTs and non-randomized observational studies of TXA versus control (no TXA, placebo, or active control such as low-dose TXA, aprotinin, and epsilon aminocaproic acid) enrolling adult patients undergoing cardiac surgery and reporting the postoperative incidence of seizures as an outcome...
March 6, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28262982/high-current-injection-into-dynamic-p-n-homojunction-in-polymer-light-emitting-electrochemical-cells
#17
Tomo Sakanoue, Jinpeng Li, Hisaaki Tanaka, Ryota Ito, Shimpei Ono, Shin-Ichi Kuroda, Taishi Takenobu
Ions and electrons in blends of polymer-electrolyte can work in ensemble to operate light-emitting electrochemical cells (LECs), in which the unique features of in situ formed p-n homojunctions offer efficient charge injection and transport. However, electrochemical features give rise to significant stability and speed issues due to limited electrochemical stability and low ion mobility, resulting in low brightness and a slow response of LECs. Here, these issues are overcome by the separate control of ionic and electronic charges, using a simple driving pulse superimposed on a small base voltage; ions with slow response are rearranged by a constant base voltage, while a high-voltage pulse, superimposed upon the base, injects electrons/holes which have fast response, with minimal effect on the ions...
March 6, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28261542/syrmep-tomo-project-a-graphical-user-interface-for-customizing-ct-reconstruction-workflows
#18
Francesco Brun, Lorenzo Massimi, Michela Fratini, Diego Dreossi, Fulvio Billé, Agostino Accardo, Roberto Pugliese, Alessia Cedola
When considering the acquisition of experimental synchrotron radiation (SR) X-ray CT data, the reconstruction workflow cannot be limited to the essential computational steps of flat fielding and filtered back projection (FBP). More refined image processing is often required, usually to compensate artifacts and enhance the quality of the reconstructed images. In principle, it would be desirable to optimize the reconstruction workflow at the facility during the experiment (beamtime). However, several practical factors affect the image reconstruction part of the experiment and users are likely to conclude the beamtime with sub-optimal reconstructed images...
2017: Advanced Structural and Chemical Imaging
https://www.readbyqxmd.com/read/28256249/trends-in-vascular-complications-in-high-risk-patients-following-transcatheter-aortic-valve-replacement-in-the-united-states
#19
Tomo Ando, Emmanuel Akintoye, Tesfaye Telila, Alexandros Briasoulis, Hisato Takagi, Cindy L Grines, Luis Afonso
Vascular complications (VC) following transcatheter aortic valve replacement (TAVR) are associated with worse outcomes. The trend of VC incidence in patients considered high risk is unclear. We sought to assess the trend of VC after TAVR in patients at high risk. We investigated the VC trend in female, diabetes mellitus, and peripheral vascular disease (PVD) patients. Patients who underwent TAVR from 2011 to 2014 in the United States were identified using the International Classification of Diseases-Ninth Revision code 35...
February 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28237641/sternal-metastasis-as-first-presentation-of-a-well-differentiated-papillary-thyroid-carcinoma
#20
Eleftherios Spartalis, Demetrios Moris, Periklis Tomos
No abstract text is available yet for this article.
February 22, 2017: Surgery
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