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https://www.readbyqxmd.com/read/27908453/volumetric-modulated-arc-therapy-with-dynamic-collimator-rotation-for-improved-multileaf-collimator-tracking-of-the-prostate
#1
Ghulam Murtaza, Jakob Toftegaard, Ehsan Ullah Khan, Per Rugaard Poulsen
PURPOSE: To improve MLC tracking of prostate VMAT plans by dynamic rotation of the collimator to align the MLC leaves with the dominant prostate motion direction. METHODS: For 22 prostate cancer patients, two dual arc VMAT plans were made with (1) fixed collimators (45° and 315°) and (2) a rotating collimator that aligned the MLC leaves with the dominant prostate motion direction (population-based first principal component). The fixed and rotating collimator plan quality was compared using selected dose-volume indices...
November 28, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27906103/progressive-impairment-of-cav1-1-function-in-the-skeletal-muscle-of-mice-expressing-a-mutant-type-1-cu-zn-superoxide-dismutase-g93a-linked-to-amyotrophic-lateral-sclerosis
#2
Donald Beqollari, Christin F Romberg, Gabriella Dobrowolny, Martina Martini, Andrew A Voss, Antonio Musarò, Roger A Bannister
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder that is typically fatal within 3-5 years of diagnosis. While motoneuron death is the defining characteristic of ALS, the events that underlie its pathology are not restricted to the nervous system. In this regard, ALS muscle atrophies and weakens significantly before presentation of neurological symptoms. Since the skeletal muscle L-type Ca(2+) channel (CaV1.1) is a key regulator of both mass and force, we investigated whether CaV1...
June 23, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27904901/effect-of-ticagrelor-on-endothelial-calcium-signalling-and-barrier-function
#3
Dursun Gündüz, Christian Tanislav, Klaus-Dieter Schlüter, Rainer Schulz, Christian Hamm, Muhammad Aslam
The P2Y12 receptor is a Gi-coupled receptor whose activation inhibits adenylyl cyclase and thereby reduces the concentration of intracellular cAMP. Here the hypothesis was tested whether AR-C 66096 or ticagrelor, two direct-acting and reversibly binding P2Y12 receptor antagonists, protect endothelial cell (EC) barrier function by raising intracellular cAMP in ECs. The study was carried out on primary human umbilical vein ECs (HUVECs) and human pulmonary microvascular ECs (hPMECs). AR-C66096 (10 µM) induced a 50 % increase in cAMP in ECs whereas ticagrelor (2-10 µM) had no effect...
December 1, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27904131/mir-31-regulates-rho-associated-kinase-myosin-light-chain-rock-mlc-pathway-and-inhibits-gastric-cancer-invasion-roles-of-rhoa
#4
Zhuo Chen, Shengnan Liu, Yuan Xia, Kejian Wu
BACKGROUND This study evaluated how the expression of miR-31 can be used to detect gastric cancer (GC) to help illuminate the role of miR-31 and RhoA in GC cells. MATERIAL AND METHODS We carried out our experiments using tissue specimens from 70 GC patients. The relative expression of miR-31 and RhoA mRNA in tissues and cells was detected by RT-PCR. The expression level of RhoA protein was detected by immunohistochemistry. GC cell line BGC-823 was transfected with six groups of vectors: blank group, NC (negative control) group, miR-31 mimics group, miR-31 mimics + RhoA group, miR-31 mimics + ROCK group, and miR-31 mimics + MLCK agonist group...
December 1, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27897141/measured-and-monte-carlo-simulated-electron-backscatter-to-the-monitor-chamber-for-the-varian-truebeam-linac
#5
Samantha A M Lloyd, Isabelle M Gagne, Magdalena Bazalova-Carter, Sergei Zavgorodni
To accurately simulate therapeutic electron beams using Monte Carlo methods, backscatter from jaws into the monitor chamber must be accounted for via the backscatter factor, S b. Measured and simulated values of S b for the TrueBeam are investigated. Two approaches for measuring S b are presented. Both require service mode operation with the dose and pulse forming networking servos turned off in order to assess changes in dose rate with field size. The first approach samples an instantaneous dose rate, while the second approach times the delivery of a fixed number of monitor units to assess dose rate...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27895893/downregulation-of-long-non-coding-rna-h19-promotes-p19cl6-cells-proliferation-and-inhibits-apoptosis-during-late-stage-cardiac-differentiation-via-mir-19b-modulated-sox6
#6
Yu Han, Hongdang Xu, Jiangtao Cheng, Yanwei Zhang, Chuanyu Gao, Taibing Fan, Bangtian Peng, Bin Li, Lin Liu, Zhaoyun Cheng
BACKGROUND: Regulating cardiac differentiation to maintain normal heart development and function is very important. At present, biological functions of H19 in cardiac differentiation is not completely clear. METHODS: To explore the functional effect of H19 during cardiac differentiation. Expression levels of early cardiac-specific markers Nkx-2.5 and GATA4, cardiac contractile protein genes α-MHC and MLC-2v were determined by qRT-PCR and western lot. The levels of lncRNA H19 and miR-19b were detected by qRT-PCR...
2016: Cell & Bioscience
https://www.readbyqxmd.com/read/27895719/drabal-novel-method-to-mine-large-high-throughput-screening-assays-using-bayesian-active-learning
#7
Othman Soufan, Wail Ba-Alawi, Moataz Afeef, Magbubah Essack, Panos Kalnis, Vladimir B Bajic
BACKGROUND: Mining high-throughput screening (HTS) assays is key for enhancing decisions in the area of drug repositioning and drug discovery. However, many challenges are encountered in the process of developing suitable and accurate methods for extracting useful information from these assays. Virtual screening and a wide variety of databases, methods and solutions proposed to-date, did not completely overcome these challenges. This study is based on a multi-label classification (MLC) technique for modeling correlations between several HTS assays, meaning that a single prediction represents a subset of assigned correlated labels instead of one label...
2016: Journal of Cheminformatics
https://www.readbyqxmd.com/read/27894406/vincristine-promotes-migration-and-invasion-of-colorectal-cancer-hct116-cells-through-rhoa-rock-myosin-light-chain-pathway
#8
X Jin, K Liu, B Jiao, X Wang, S Huang, W Ren, K Zhao
Vincristine is an antitumor vinca alkaloid isolated from vinca rosea, and is a medication used to treat a number of types of cancer. In this study, we investigated the impact of vincristine on oncogenic phenotypes of human colorectal cancer HCT116 cells. MTT assay demonstrated that vincristine showed a obviously inhibitory effect on cell growth compared to non-treated cells. However, Transwell assay showed that vincristine promoted migration and invasion of HCT116 cells in vitro in a concentration-dependent manner between 0...
October 31, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27885705/multiple-linear-combination-mlc-regression-tests-for-common-variants-adapted-to-linkage-disequilibrium-structure
#9
Yun Joo Yoo, Lei Sun, Julia G Poirier, Andrew D Paterson, Shelley B Bull
By jointly analyzing multiple variants within a gene, instead of one at a time, gene-based multiple regression can improve power, robustness, and interpretation in genetic association analysis. We investigate multiple linear combination (MLC) test statistics for analysis of common variants under realistic trait models with linkage disequilibrium (LD) based on HapMap Asian haplotypes. MLC is a directional test that exploits LD structure in a gene to construct clusters of closely correlated variants recoded such that the majority of pairwise correlations are positive...
November 25, 2016: Genetic Epidemiology
https://www.readbyqxmd.com/read/27885084/analysis-of-neutron-production-in-passively-scattered-ion-beam-therapy
#10
Seunguk Heo, Seunghoon Yoo, Yongkeun Song, Eunho Kim, Jaeik Shin, Soorim Han, Wongyun Jung, Sanghee Nam, Rena Lee, Kitae Lee, Sungho Cho
A new treatment facility for heavy ion therapy since 2010 was constructed. In the broad beam, a range shifter, ridge filter and multi leaf collimator (MLC) for the generation of the spread-out Bragg peak is used. In this case, secondary neutrons produced by the interactions of the ion field with beam-modifying devices (e.g. double-scattering system, beam shaping collimators and range compensators) are very important for patient safety. Therefore, these components must be carefully examined in the context of secondary neutron yield and associated secondary cancer risk...
November 24, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27877159/efficacy-of-antibacterial-peptides-against-peptide-resistant-mrsa-is-restored-by-permeabilization-of-bacteria-membranes
#11
Joshua Ravensdale, Zachary Wong, Frances O'Brien, Keith Gregg
Clinical application of antimicrobial peptides (AMPs), as with conventional antibiotics, may be compromised by the development of bacterial resistance. This study investigated AMP resistance in methicillin resistant Staphylococcus aureus, including aspects related to the resilience of the resistant bacteria toward the peptides, the stability of resistance when selection pressures are removed, and whether resistance can be overcome by using the peptides with other membrane-permeabilising agents. Genotypically variant strains of S...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27877086/ginsenoside-rg1-protects-against-oxidative-stress-induced-neuronal-apoptosis-through-myosin-iia-actin-related-cytoskeletal-reorganization
#12
Yan Wang, Qian Liu, Yingqiong Xu, Yuanyuan Zhang, Yanni Lv, Yisha Tan, Nan Jiang, Guosheng Cao, Xiaonan Ma, Jingrong Wang, Zhengyu Cao, Boyang Yu, Junping Kou
Oxidative stress-induced cytoskeletal dysfunction of neurons has been implicated as a crucial cause of cell apoptosis or death in the central nervous system (CNS) diseases, such as neurodegenerative and psychiatric diseases. The application of neuroprotectants rescuing the neurons from cytoskeletal damage and apoptosis can be a potential treatment for these CNS diseases. Ginsenoside Rg1 (Rg1), one of the major active components of ginseng, has been reported possessing notable neuroprotective activities. However, there is rare report about its effect on cytoskeleton and its undergoing mechanism...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27869798/gluten-induced-symptoms-in-diarrhea-predominant-irritable-bowel-syndrome-are-associated-with-increased-myosin-light-chain-kinase-activity-and-claudin-15-expression
#13
Richard L Wu, Maria I Vazquez-Roque, Paula Carlson, Duane Burton, Madhusudan Grover, Michael Camilleri, Jerrold R Turner
The mechanisms underlying diarrhea-predominant irritable bowel syndrome (IBS-D) are poorly understood, but increased intestinal permeability is thought to contribute to symptoms. A recent clinical trial of gluten-free diet (GFD) demonstrated symptomatic improvement, relative to gluten-containing diet (GCD), which was associated with reduced intestinal permeability in non-celiac disease IBS-D patients. The aim of this study was to characterize intestinal epithelial tight junction composition in IBS-D before and after dietary gluten challenge...
November 21, 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27866190/role-of-mcpip1-in-the-endothelial-mesenchymal-transition-induced-by-silica
#14
Jie Chao, Xingang Wang, Yuxia Zhang, Tiebing Zhu, Wei Zhang, Zewei Zhou, Jian Yang, Bing Han, Yusi Cheng, Xiaojie Tu, Honghong Yao
BACKGROUND: Silicosis is characterized by the accumulation of fibroblasts and the excessive deposition of extracellular matrix. Fibroblast generation via endothelial-mesenchymal transition (EndMT) is one process responsible for this accumulation of fibroblasts. However, the mechanisms underlying EndMT remain unknown. METHODS: Human umbilical vein endothelial cells (HUVECs) were exposed to SiO2 (50 µg/cm2). Specific endothelial and mesenchymal markers were evaluated using immunofluorescence and western blot analysis...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27862456/heat-resistant-mechanoluminescent-chromism-of-the-hybrid-molecule-based-on-boron-ketoiminate-modified-octa-substituted-polyhedral-oligomeric-silsesquioxane
#15
Kazumasa Suenaga, Kazuo Tanaka, Yoshiki Chujo
This manuscript reports the rational design and development of the heat-resistant mechanoluminescent chromic (MLC) molecule based on a photoluminescent organoboron dye and an organic-inorganic hybrid molecular scaffold. Luminescent organoboron complexes were introduced into polyhedral oligomeric silsesquioxane (POSS) at each vertex via the rigid linker structure not only for suppressing molecular interaction which induces concentration quenching but also for obtaining high molecular symmetry which would be favorable to enhance heat resistance...
November 14, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27859243/effect-of-infusion-of-mabs-to-tnfrsf25-on-graft-rejection-in-allo-immune-mice-receiving-autologous-marrow-transplantation
#16
Reginald M Gorczynski, Hassan Sadozai, Fang Zhu, Ismat Khatri
Significant barriers to transplantation exist for individuals who are pre-sensitized to donor Ag and have high titres of donor-reactive Ab. We report the effect of autologous BMTx after myeloablation in pre-sensitized mice along with the use of mAbs to TNFRSF25, expressed on Tregs. C57BL/6 mice, which had been sensitized earlier with BALB/c skin allografts, received secondary BALB/c grafts after the primary grafts had been rejected. Subsequently, recipient mice underwent myeloablation with cyclophosphamide and busulphan and were injected with T-cell depleted bone marrow from CD45...
November 17, 2016: Immunology
https://www.readbyqxmd.com/read/27834902/mechanical-fault-diagnosis-of-high-voltage-circuit-breakers-based-on-variational-mode-decomposition-and-multi-layer-classifier
#17
Nantian Huang, Huaijin Chen, Guowei Cai, Lihua Fang, Yuqiang Wang
Mechanical fault diagnosis of high-voltage circuit breakers (HVCBs) based on vibration signal analysis is one of the most significant issues in improving the reliability and reducing the outage cost for power systems. The limitation of training samples and types of machine faults in HVCBs causes the existing mechanical fault diagnostic methods to recognize new types of machine faults easily without training samples as either a normal condition or a wrong fault type. A new mechanical fault diagnosis method for HVCBs based on variational mode decomposition (VMD) and multi-layer classifier (MLC) is proposed to improve the accuracy of fault diagnosis...
November 10, 2016: Sensors
https://www.readbyqxmd.com/read/27825172/oxidized-low-density-lipoprotein-induced-cyclophilin-a-secretion-requires-rock-dependent-diphosphorylation-of-myosin-light-chain
#18
Zizhuo Su, Rongjie Lin, Yuyang Chen, Xiaorong Shu, Haifeng Zhang, Shumin Liang, Ruqiong Nie, Jingfeng Wang, Shuanglun Xie
OBJECTIVE: Accumulation of cyclophilin A (CyPA) within atherosclerotic lesions is thought to be implicated in the progression of atherosclerosis. However, the source of CyPA within atherosclerotic lesions is still unknown. The aim of this study is to determine the role of oxidized low-density lipoproteins (ox-LDL) in vascular smooth muscle cell (VSMC)-derived CyPA secretion and the underlying mechanism. METHODS AND RESULTS: Abundant CyPA and α-smooth muscle actin (α-SMA) expressed in atherosclerotic lesions was observed in apolipoprotein E-deficient mice...
November 9, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27821135/comparisons-of-volumetric-modulated-arc-therapy-vmat-quality-assurance-qa-systems-sensitivity-analysis-to-machine-errors
#19
Bin Liang, Bo Liu, Fugen Zhou, Fang-Fang Yin, Qiuwen Wu
BACKGROUND: In volumetric modulated arc therapy (VMAT), gantry angles, dose rate and the MLC positions vary with the radiation delivery. The quality assurance (QA) system should be able to catch the planning and machine errors. The aim of this study was to investigate the sensitivity of three VMAT QA systems to machine errors. METHODS: Several types of potential linac machine errors unique to VMAT delivery were simulated in sinusoidal function of gantry angle, including gantry angle itself, MLC position and linac output...
November 7, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27819278/hepacam-associates-with-connexin-43-and-enhances-its-localization-in-cellular-junctions
#20
Meihui Wu, Mei Chung Moh, Herbert Schwarz
HepaCAM (GlialCAM) is frequently deleted in carcinomas, and reintroduction of hepaCAM into transformed cell lines reduces cellular growth and induces senescence. Mutations in HEPACAM give rise to the neurodegenerative disease megalencephalic leukoencephalopathy with subcortical cysts (MLC) since mutated hepaCAM prevents shuttling of MLC1 protein to astrocytic junctions in the plasma membrane. Here we identify that hepaCAM associates with connexin 43, a main component of gap junctions, and enhances connexin 43 localization to the plasma membrane at cellular junctions...
November 7, 2016: Scientific Reports
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