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https://www.readbyqxmd.com/read/28240007/delineation-of-margins-for-the-planning-target-volume-ptv-for-image-guided-radiotherapy-igrt-of-gastric-cancer-based-on-intrafraction-motion
#1
Paulina Leszczyńska, Wojciech Leszczyński, Jerzy Wydmański, Dębiec Kinga, Agnieszka Namysł Kaletka, Andrzej Tukiendorf, Leszek Hawrylewicz
Background: Application of the image-guided radiotherapy (IGRT) system for gastric cancer involving daily verification of patient positioning on the treatment machine allows minimisation of geometrical errors as a consequence of intra- and inter-fraction motion. The purpose of this study was to define the intrafraction motion in gastric cancer patients during a treatment session based on the IGRT system and designation of margins around the clinical target volume CTV (internal target volume ITV) necessary to delineate the planning target volume (PTV)...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240006/effects-of-six-weeks-endurance-training-and-aloe-vera-supplementation-on-cox-2-and-vegf-levels-in-mice-with-breast-cancer
#2
Saeed Shirali, Alireza Barari, Seyed Ahmad Hosseini, Elaheh Khodadi
The aim of this study was to determine effects of six weeks endurance training and Aloe Vera supplementation on COX-2 and VEGF levels in mice with breast cancer. For this purpose, 35 rats were randomly divided into 5 groups: control (healthy) and 4 cancer groups: control (cancer only), training, Aloe Vera and Aloe Vera + training. Breast cancer tumors were generated in mice by implantind. The training program comprised six weeks of swimming training accomplished in three sessions per week. Training time started with 10 minutes on the first day and increased to 60 minutes in the second week and the water flow rate was increased from 7 to 15 liters per minute at a constant rate...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28239998/effects-of-colostrum-serum-on-the-serotonergic-system-in-the-dorsal-raphe-nuclei-of-exercised-rats
#3
Seo JInhee, Kim Tae-Woon, Kim Chang-Ju
Purpose: The central fatigue hypothesis suggests that exhaustion, or the maximum level of exercise, induces excessive stress and increases serotonin concentrations in the brain, which in turn decreases central nervous system (CNS) function and induces fatigue. Our aim was to determine the effects of colostrum serum on the serotonergic system in the dorsal raphe nuclei during exhaustive exercise. Methods: Animals were randomly divided into five groups: control, exercise, exercise and treatment with 50, 100, and 200 mg/kg of colostrum serum...
February 24, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28239997/effects-of-different-doses-of-silk-peptide-on-energy-metabolism-during-exercise-in-mice
#4
Suh Heajung, Kim Jisu, Park Jonghoon, Kim Bokyung, Lee Chi-Ho, Lim Kiwon
Purpose: This study was carried out to determine the optimal dose of silk peptide for enhancing fat metabolism during exercise. Methods: Fifty male ICR mice were randomly divided into five groups: Sed, SP0, SP200, SP400, and SP800. All SP mice underwent training by running on a treadmill 5 times a week for 2 weeks (20 m/min, 8° slope, 50 min/day for the first week and 25 m/min, 8° slope, 50 min/day at about 70-75% of maximum oxygen uptake for the second week)...
February 24, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28239987/effects-of-alloantibodies-to-human-leukocyte-antigen-on-endothelial-expression-and-serum-levels-of-thrombomodulin
#5
Stéphanie Béland, Patrice Vallin, Olivier Désy, Eric Lévesque, Sacha A De Serres
RATIONALE: Thrombomodulin (TBM) is an anticoagulant and anti-inflammatory transmembrane protein expressed on endothelial cells. Donor-specific alloantibodies, particularly those against human leukocyte antigen (HLA) class II, are associated with microvascular endothelial damage in solid allografts. OBJECTIVE: Our aim was to characterize the effects of anti-HLA antibodies on endothelial expression of TBM, and in particular, the differential effects of anti-HLA class I compared with those of anti-HLA class II...
February 26, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28239983/targeted-deletion-of-gd3-synthase-protects-against-mptp-induced-neurodegeneration
#6
Yada Akkhawattanangkul, Panchanan Maiti, Yi Xue, Dipendra Aryal, William C Wetsel, David Hamilton, Stephen C Fowler, Michael P McDonald
Parkinson's disease is a debilitating neurodegenerative condition for which there is no cure. Converging evidence implicates gangliosides in the pathogenesis of several neurodegenerative diseases, suggesting a potential new class of therapeutic targets. We have shown that interventions that simultaneously increase the neuroprotective GM1 ganglioside and decrease the pro-apoptotic GD3 ganglioside-such as inhibition of GD3 synthase (GD3S) or administration of sialidase-are neuroprotective in vitro and in a number of preclinical models...
February 27, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28239939/combining-the-gpr40-agonist-fasiglifam-with-sitagliptin-improves-glycemic-control-in-patients-with-type-2-diabetes-with-or-without-metformin-a-randomized-12-week-trial
#7
Xuejun V Peng, John F Marcinak, Marsha G Raanan, Charlie Cao
AIMS: To evaluate the efficacy and safety of fasiglifam, an orally active G protein-coupled receptor 40 agonist, in combination with the dipeptidyl peptidase-4 inhibitor sitagliptin, in patients with type 2 diabetes inadequately controlled with diet/exercise (± metformin). METHODS: In this randomized, double-blind, phase II study, 368 patients received once-daily placebo, sitagliptin 100 mg, fasiglifam 25 or 50 mg, or the combination of sitagliptin 100 mg plus fasiglifam 25 or 50 mg...
February 27, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28239924/cannabinoids-as-gastrointestinal-anti-inflammatory-drugs
#8
REVIEW
A Fabisiak, J Fichna
In this mini-review, we focus on the potential of the endocannabinoid system as a target for novel therapies to treat gastrointestinal (GI) inflammation. We discuss the organization of the endocannabinoid signaling and present possible pharmacological sites in the endocannabinoid system. We also refer to recent clinical findings in the field. Finally, we point at the potential use of cannabinoids at low, non-psychoactive doses to counteract non-inflammatory pathological events in the GI tract, like chemotherapy-induced diarrhea, as evidenced by Abalo et al...
March 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28239898/early-signal-of-diverted-use-of-tropicamide-eye-drops-in-france
#9
Camille Ponté, Christian Pi, Aurore Palmaro, Emilie Jouanjus, Maryse Lapeyre-Mestre
BACKGROUND: Tropicamide is a mydriatic drug used as eye-drops for diagnostic or therapeutic purposes. From 2013, a diverted use by intravenous route has been suspected in Eastern Europe in opioids users. To recent date, no signal of a misuse has been identified in France. PURPOSE: To investigate an early signal of a diverted use of tropicamide eye drops and to collect information regarding motives of misusing and tropicamide-induced effects. METHODS: Information was obtained at 1/ regional level (Midi-Pyrénées area): reimbursement data and pharmacists' reports on suspicious requests, 2/ national level: reimbursement data and prescriptions suggesting possible abuse from the OSIAP (Ordonnances Suspectes, Indicateur d'Abus Possible) survey and 3/ international level: VigiBase® reports and Web sources...
February 27, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28239897/population-pharmacokinetics-of-rituximab-in-patients-with-diffuse-large-b-cell-lymphoma-and-association-with-clinical-outcome
#10
S Rozman, I Grabnar, S Novaković, A Mrhar, B J Novaković
AIMS: Pharmacokinetic (PK) studies suggest that there is a room for improvement in clinical use of rituximab through more individualized treatment. The objective of this study was to characterize rituximab PK in 29 newly diagnosed patients with diffuse large B-cell lymphoma treated with rituximab in combination with cyclophosphamide, doxorubicin, vincristine and methylprednisolone every three weeks. We also evaluated the association of rituximab PK with clinical outcome. METHODS: Rituximab serum levels were determined by enzyme-linked immunosorbent assay and evaluated by a population PK analysis applying non-linear mixed effects modelling...
February 27, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28239866/influence-of-vasomodulators-and-tumor-transplantation-on-the-disposition-of-5-fluorouracil-after-application-to-the-liver-surface-in-rats
#11
Yukinobu Kodama, Miyuki Horishita, Ayako Tokunaga, Hirotaka Miyamoto, Shintaro Fumoto, Hitoshi Sasaki, Junzo Nakamura, Koyo Nishida
This study investigated the effect of epinephrine (a vasoconstrictor) and hydralazine (a vasodilator) on the hepatic disposition of 5-fluorouracil (5-FU) after application to the liver surface in rats. Normal livers were compared with a Walker 256 carcinoma cell tumor model. A cylindrical diffusion cell was attached to the liver surface. 5-FU was added into the diffusion cell in combination with vasomodulators or after pretreatment with epinephrine. After selected treatment times, 5-FU concentrations were assayed at three sites in the excised livers...
February 27, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28239860/hypovitaminosis-a-in-extensively-grazed-beef-cattle
#12
E M Parker, C P Gardiner, A E Kessell, A J Parker
CASE REPORT: Vitamin A deficiency was diagnosed in a herd of 97 19-month-old Braford heifers in the Mitchell Grass Downs (Astrebla spp.) bioregion of Hughenden in north-western Queensland during November 2015. Two heifers died after a 48-h history of sternal recumbency and of the 19 that had neurological signs, 7 were blind. Histological changes in the optic nerves of the two necropsied cattle were consistent with vitamin A deficiency. This diagnosis was supported by vitamin A concentrations in fresh liver samples of 5 and 6 mg/kg wet tissue (reference range, 100-175 mg/kg) despite treatment of the cattle with twice the recommended dose of parenteral vitamin A 3 weeks prior to sampling...
March 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28239801/curcumin-protects-against-tartrazine-mediated-oxidative-stress-and-hepatotoxicity-in-male-rats
#13
G E El-Desoky, A Abdel-Ghaffar, Z A Al-Othman, M A Habila, Y A Al-Sheikh, H K Ghneim, J P Giesy, M A M Aboul-Soud
OBJECTIVE: Synthetic dyes have been reported to exert detrimental effects on the health of humans. This study evaluated the effects of a diet containing tartrazine (Tz) on rats which included: i) biochemical parameters including hepatic enzymes, kidney functions and profiles of lipids; ii) markers of oxidative stress in cells by measuring concentrations of malondialdehyde (MDA) and glutathione (GSH); iii) activities of selected, key hepatic antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx); iv) pathologies of liver...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239792/involvement-of-glycogen-synthase-kinase-3-in-the-mechanisms-of-conditioned-food-aversion-memory-reconsolidation
#14
V P Nikitin, S V Solntseva, S A Kozyrev
Experiments were performed on the snails trained in conditioned food aversion for 3 days. Injection of TDZD-8 (glycogen synthase kinase-3 inhibitor, 2 mg/kg) in combination with reminder (presentation of a conditioned food stimulus) led to memory impairment developing 3 days after inhibitor/reminder exposure and followed by spontaneous recovery in 10 days. Injections of TDZD-8 in a dose of 4 or 20 mg/kg before reminder were shown to cause amnesia that persisted for more than 10 days. Memory recovery during repeated training was observed at the earlier period than after initial training...
February 27, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28239770/toxic-epidermal-necrolysis-in-a-child-with-lupus-associated-pancreatitis
#15
REVIEW
Stevic Marija, Budic Ivana, Ristic Nina, Nenadic Dragan, Bokun Zlatko, Jovanovic Branislav, Pejanovic Jelena, Simic Dusica
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening dermatological conditions that are characterized by mucosal erosions, epidermal detachments and erosions. The most common causes of SJS and TEN are drugs; other causes such as systemic lupus erythematosus (SLE), vaccinations and infections have been rarely implicated. We present the case of a 14-year-old female patient with acute pancreatitis as an initial manifestation of systemic lupus erythematosus, complicated by the toxic epidermal necrolysis with a fatal outcome...
February 26, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28239691/wood-combustion-particles-induce-adverse-effects-to-normal-and-diseased-airway-epithelia
#16
Manuel Krapf, Lisa Künzi, Sandrine Allenbach, Emily A Bruns, Ilaria Gavarini, Imad El-Haddad, Jay G Slowik, André S H Prévôt, Luka Drinovec, Griša Močnik, Lutz Dümbgen, Matthias Salathe, Nathalie Baumlin, Constantinos Sioutas, Urs Baltensperger, Josef Dommen, Marianne Geiser
Residential wood burning is a major source of poorly characterized, deleterious particulate matter, whose composition and toxicity may vary with wood type, burning condition and photochemical age. The causative link between ambient wood particle constituents and observed adverse health effects is currently lacking. Here we investigate the relationship between chemical properties of primary and atmospherically aged wood combustion particles and acute toxicity in human airway epithelial cells. Emissions from a log wood burner were diluted and injected into a smog chamber for photochemical aging...
February 27, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28239679/adenovirus-serotype-5-vaccine-vectors-trigger-il-27-dependent-inhibitory-cd4-t-cell-responses-that-impair-cd8-t-cell-function
#17
Rafael A Larocca, Nicholas M Provine, Malika Aid, M Justin Iampietro, Erica N Borducchi, Alexander Badamchi-Zadeh, Peter Abbink, David Ng'ang'a, Christine A Bricault, Eryn Blass, Pablo Penaloza-MacMaster, Kathryn E Stephenson, Dan H Barouch
Adenovirus serotype 5 (Ad5) vaccine vectors elicit robust CD8(+) T cell responses, but these responses typically exhibit a partially exhausted phenotype. However, the immunologic mechanism by which Ad5 vectors induce dysfunctional CD8(+) T cells has not previously been elucidated. Here we demonstrate that, following immunization of B6 mice, Ad5 vectors elicit antigen-specific IL-10(+)CD4(+) T cells with a distinct transcriptional profile in a dose-dependent fashion. In rhesus monkeys, we similarly observed upregulated expression of IL-10 and PD-1 by CD4(+) T cells following Ad5 vaccination...
November 2016: Science Immunology
https://www.readbyqxmd.com/read/28239627/self-administration-of-smokeless-tobacco-products-in-rats
#18
Mark G LeSage, Danielle Burroughs, Peter Muelken, Andrew C Harris
OBJECTIVE: Preclinical abuse liability assessment is an essential component of tobacco regulatory science. The goal of this project was to evaluate the relative abuse liability of smokeless tobacco products in rats using aqueous extracts of those products. These extracts provide exposure to an extensive range of nicotine and non-nicotine tobacco constituents as occurs in humans. METHODS: Rats were trained to self-administer either nicotine alone or extracts of Camel Snus or Kodiak smokeless tobacco at an equivalent nicotine unit dose...
October 2016: Tobacco Regulatory Science
https://www.readbyqxmd.com/read/28239615/apomorphine-subcutaneous-injection-for-the-management-of-morning-akinesia-in-parkinson-s-disease
#19
Stuart Isaacson, Mark Lew, William Ondo, Jean Hubble, Thomas Clinch, Fernando Pagan
BACKGROUND: In patients with motor fluctuations complicating Parkinson's disease (PD), delays in time-to-ON with levodopa are common. This open-label study aimed to assess the effect of apomorphine on time-to-ON in PD patients with morning akinesia. METHODS: The safety population included 127 enrolled patients, and the full analysis set (FAS) included 88 patients. Patients completed a 7-day levodopa baseline period recording their time-to-ON following each morning dose of levodopa...
January 2017: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/28239608/elimination-of-dog-mediated-human-rabies-deaths-by-2030-needs-assessment-and-alternatives-for-progress-based-on-dog-vaccination
#20
Ryan M Wallace, Eduardo A Undurraga, Jesse D Blanton, Julie Cleaton, Richard Franka
BACKGROUND: Rabies imposes a substantial burden to about half of the world population. The World Health Organization (WHO), World Organization for Animal Health, and the Food and Agriculture Organization have set the goal of eliminating dog-mediated human rabies deaths by 2030. This could be achieved largely by massive administration of post-exposure prophylaxis-in perpetuity-, through elimination of dog rabies, or combining both. Here, we focused on the resources needed for the elimination of dog rabies virus by 2030...
2017: Frontiers in Veterinary Science
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