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https://www.readbyqxmd.com/read/29783225/-features-of-exchange-of-calcium-saliva-in-patients-with-gastroesophageal-reflux-disease
#1
Mykola А Bychkov, Maryana М Yakhnitska
OBJECTIVE: Introduction: The pathogenesis of gastroesophageal reflux disease (GERD) is a topical issue of modern gastroenterology. There are a number of scientific papers on changes in the qualitative and quantitative composition of saliva, which triggers a cascade of biochemical reactions, the consequence of which is the destruction of the resistance of the mucous membrane of the esophagus. Calcium is a macro element that provides the normal functioning of cells. Parathormone also regulates the metabolism of calcium in the body...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783224/influence-of-risk-factors-on-insulin-resistance-in-patients-with-overweight-and-obesity
#2
Tetiana Maksymets, Natalia Karpyshyn, Taras Gutor, Helen Sklyarova, Eugen Sklyarov
OBJECTIVE: Introduction: Obesity is a multifactorial, heterogenic disease, associated with an increased risk of morbidity and mortality due to cardiovascular diseases, diabetes, cancer, chronic liver and kidney diseases. Excessive body weight and obesity are serious medical and social problems, since their incidence is constantly increasing and has reached global epidemic proportions. The aim: Determining the influence of risk factors on insulin resistance level in patients with overweight and obesity...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783198/toxicity-assessment-of-metal-oxide-nano-pollutants-on-tomato-solanum-lycopersicon-a-study-on-growth-dynamics-and-plant-cell-death
#3
Bilal Ahmed, Mohammad Saghir Khan, Javed Musarrat
The present study for the first time demonstrated the interactions of metal oxide (MO) nano-pollutants (CuO and Al2 O3 -NPs) with tissues and cellular DNA of tomato plants grown in soil sand: silt: clay (667:190:143) and Hoagland-hydroponic system and assessed the hazardous effects of NPs on cell physiology and biochemistry. Results of SEM equipped with EDX revealed attachment of variably shaped CuO-NPs (18 nm) and Al2 O3 -NPs (21 nm) on roots, and internalization followed by translocation in plants by ICP-MS and TEM...
May 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29783089/self-stabilized-silk-sericin-based-nanoparticles-in-vivo-biocompatibility-and-reduced-doxorubicin-induced-toxicity
#4
Doudou Hu, Ting Li, Zongpu Xu, Di Liu, Mingying Yang, Liangjun Zhu
A variety of colloid stabilizers and cryoprotectants confer improved nanoparticle (NP) colloidal stability and redisperability. However, the discounted tumor targetability, delivery efficacy and possible side effects limit the application in the vascular delivery of NPs. Here we present the water-soluble silk sericin (SS) not only as a material for the preparation of NPs, but also both a dispersion stabilizer and a cryoprotectant. In the absence of any stabilizers, SS-based NPs (SSC@NPs) could resist to the serum protein adsorption, preventing the formation of particle agglomerates...
May 18, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29783074/fsh-receptor-binding-inhibitor-restrains-follicular-development-and-possibly-attenuates-carcinogenesis-of-ovarian-cancer-through-down-regulating-expression-levels-of-fshr-and-er%C3%AE-in-normal-ovarian-tissues
#5
Gong Zhuandi, Che Tuanjie, Lai Luju, Ayimuguli Abdiryim, Deng Yingying, Liang Haoqin, Wei Suocheng, Ding Li
OBJECTIVES: The current study aimed to investigate FSH receptor binding inhibitor (FRBI) effects in the expressions of FSH receptor (FSHR) and estrogen receptor-beta (ERβ) in the mice ovaries at the gene and protein levels, also to find the potential efficacy of FRBI on suppressing ovarian cancer through down-regulating over-expression of FSHR and ERβ in the normal ovarian tissues. METHODS: 180 female mice were randomized into six groups (n = 30). Mice of FRBI-1, FRBI-2 and FRBI-3, FRBI-4 were intramuscularly injected with FRBI of 10, 20, 30 and 40 mg/kg, respectively, for five consecutive days...
May 18, 2018: Gene
https://www.readbyqxmd.com/read/29783025/immunogenicity-and-reactogenicity-of-high-versus-standard-dose-trivalent-inactivated-influenza-vaccine-in-healthcare-workers-a-pilot-randomized-controlled-trial
#6
C Volling, B L Coleman, K Katz, A E Simor, M Muller, J Powis, J McElhaney, A McGeer
OBJECTIVES: To compare immunogenicity, reactogenicity and acceptability of high- and standard-dose trivalent inactivated influenza vaccine (HDTIV, SDTIV) in 18-64 year olds. METHODS: We randomized 18-64-year-olds to HDTIV or SDTIV in two consecutive years. We collected serum on Days 0 and 21, measured hemagglutination inhibition (HAI) titers, and compared seroconversion, Day 21 titers, seroprotection, reactogenicity, acceptability. RESULTS: Immunogenicity was evaluable in 42 of 47 2014 participants, all 33 both year participants, and 87 of 90 2015-only participants...
May 18, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29783019/total-flavonoid-extract-of-epimedium-herb-increases-the-peak-bone-mass-of-young-rats-involving-enhanced-activation-of-the-ac10-camp-pka-creb-pathway
#7
Hui-Rong Xi, Hui-Ping Ma, Fang-Fang Yang, Yu-Hai Gao, Jian Zhou, Yuan-Yuan Wang, Wen-Yuan Li, Cory J Xian, Ke-Ming Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Epimedium sagittatum brevicornum Maxim. is an important traditional Chinese herb that has long been used to promote bone fracture healing and treat osteoporosis. AIM OF THE STUDY: Achieving peak bone mass by adolescence has now been accepted to be fundamental for preventing osteoporosis in adulthood life. This study investigated the possibility of increasing peak bone mass in young rats using the total flavonoid extract of Epimedium herb (TFE)...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29783018/tumor-inhibitory-effects-of-intravesical-ganoderma-lucidum-instillation-in-the-syngeneic-orthotopic-mb49-c57-bladder-cancer-mice-model
#8
J W M Yuen, D S Y Mak, E S Chan, M D I Gohel, C F Ng
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (GL) has been traditionally used in oriental medicine as superior health tonic, and there are numerous scientific evidences of its antitumorigenic activities. AIM OF THE STUDY: To evaluate the intravesical chemopreventive effects of ethanol extract of GL (GLe) on bladder cancer. MATERIALS AND METHODS: Intravesical therapy is defined as the direct instillation of a liquid drug into bladder through a catheter...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29783015/extracts-of-compound-muniziqi-granule-suppressed-uterus-contraction-and-ameliorated-oxytocin-inducedprimary-dysmenorrhea
#9
Yue Wei, Tingyun Ma, Hanxue Wang, Jianguo Xing, Yuwen Wang, Zhengyi Gu, Dandan Mu, Qiang Yin, Xuemei Cheng, Changhong Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Compound Muniziqi granule (CMG) is usually used as a traditional Uighur medicine to treat acne, chloasma, skin inflammation, primary dysmenorrhea (PDM), and menopausal syndrome. However, there are no sufficient data to support the clinic uses of CMG in PDM. AIM OF THE STUDY: This work aims to examine the effect of CMG as a treatment for PDM and reveal its possible therapeutic mechanism. MATERIALS AND METHODS: In vivo and in vitro mouse PDM models were utilized in this study...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29783006/technique-of-whole-sellar-stereotactic-radiosurgery-for-cushing-s-disease-results-from-a-multicenter-international-cohort-study
#10
Matthew J Shepard, Gautam U Mehta, Zhiyuan Xu, Hideyuki Kano, Nathaniel Sisterson, Yan-Hua Su, Michal Krsek, Ahmed M Nabeel, Amr El-Shehaby, Khaled A Kareem, Nuria Martinez-Moreno, David Mathieu, Brendan J McShane, Kevin Blas, Douglas Kondziolka, Inga Grills, John Y Lee, Roberto Martinez-Alvarez, Wael A Reda, Roman Liscak, Cheng-Chia Lee, L Dade Lunsford, Mary Lee Vance, Jason P Sheehan
BACKGROUND: Stereotactic radiosurgery (SRS) is used to manage patients with Cushing's disease (CD) who have failed surgical/medical management. As many patients with recurrent/persistent CD lack an identifiable adenoma on neuro-imaging, whole-sellar SRS has been increasingly employed. We therefore sought to define the outcomes of patients undergoing whole-sellar SRS. METHODS: An international, multicenter, retrospective cohort-design was used to define clinical/endocrine outcomes for patients undergoing whole-sellar SRS for CD...
May 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29782992/single-ultra-high-dose-cholecalciferol-to-prevent-vitamin-d-deficiency-in-pediatric-hematopoietic-stem-cell-transplantation
#11
Gregory Wallace, Sonata Jodele, Kasiani C Myers, Christopher E Dandoy, Javier El-Bietar, Adam Nelson, Ashley Teusink-Cross, Pooja Khandelwal, Cynthia Taggart, Catherine M Gordon, Stella M Davies, Jonathan C Howell
BACKGROUND: Vitamin D (vitD) deficiency is prevalent among childhood hematopoietic stem cell transplantation (HSCT) recipients and associated with inferior transplant survival at 100 days after transplantation. Achieving and maintaining therapeutic vitD levels in HSCT recipients is extremely challenging in the first 3-6 months after transplant due to poor compliance in the setting of mucositis, and concomitant use of critical transplant drugs that interfere with vitD absorption. We sought to evaluate the safety and efficacy of a single, ultra-high dose of vitD given prior to childhood HSCT to maintain levels in a therapeutic range during the peri-transplantation period...
May 18, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29782991/beneficial-and-paradoxical-roles-of-selenium-at-nutritional-levels-of-intake-in-healthspan-and-longevity
#12
REVIEW
Li Zhang, Huawei Zeng, Wen-Hsing Cheng
Accumulation of genome and macromolecule damage is a hallmark of aging, age-associated degeneration, and genome instability syndromes. Although processes of aging are irreversible, they can be modulated by genome maintenance pathways and environmental factors such as diet. Selenium (Se) confers its physiological functions mainly through selenoproteins, but Se compounds and other proteins that incorporate Se nonspecifically also impact optimal health. Bruce Ames proposed that the aging process could be mitigated by a subset of low-hierarchy selenoproteins whose levels are preferentially reduced in response to Se deficiency...
May 18, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29782988/cholesterol-crystals-increase-vascular-permeability-by-inactivating-shp2-and-disrupting-adherens-junctions
#13
Arul M Mani, Rima Chattopadhyay, Nikhlesh K Singh, Gadiparthi N Rao
To understand the adverse effects of cholesterol crystals on vascular homeostasis, we have studied their effects on endothelial barrier function. Cholesterol crystals increased endothelial barrier permeability in a dose and time dependent manner. In addition, cholesterol crystals induced tyrosine phosphorylation of VE-cadherin and α-catenin, disrupting endothelial AJ and its barrier function and these effects required xanthine oxidase-mediated H2 O2 production, SHP2 inactivation and Frk activation. Similarly, feeding C57BL/6 mice with cholesterol-rich diet increased xanthine oxidase expression, H2 O2 production, SHP2 inactivation and Frk activation leading to enhanced tyrosine phosphorylation of VE-cadherin and α-catenin, thereby disrupting endothelial AJ and increasing vascular permeability...
May 18, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29782981/cationic-starch-safe-and-economic-harvesting-flocculant-for-microalgal-biomass-and-inhibiting-e-coli-growth
#14
Mehrez E E El-Naggar, Farag A Samhan, Abeer A A Salama, Rehab M Hamdy, Gamila H Ali
Cationized starch-based flocculation processes are the subject of increasing attention because of their non-toxicity, biodegradability and relatively low price synthesized. The study aimed to evaluate the flocculability of different cationic starches using different concentrations of glycidyltrimethylammonium chloride (GTAC) with different degree of substitution (DS) ranged from 0.13 to 0.57. Cationized starch were characterized using Fourier Transform Infrared (FTIR), scanning electron microscopy (SEM) and toxicity checked using experimental animal procedure...
May 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29782961/baclofen-induced-encephalopathy-in-overdose-modeling-of-the-electroencephalographic-effect-concentration-relationships-and-contribution-of-tolerance-in-the-rat
#15
Magali Chartier, Isabelle Malissin, Salma Tannous, Laurence Labat, Patricia Risède, Bruno Mégarbane, Lucie Chevillard
Baclofen, a γ-amino-butyric acid type-B receptor agonist with exponentially increased use at high-dose to facilitate abstinence in chronic alcoholics, is responsible for increasing poisonings. Baclofen overdose may induce severe encephalopathy and electroencephalographic (EEG) abnormalities. Whether prior prolonged baclofen treatment may influence the severity of baclofen-induced encephalopathy in overdose has not been established. We designed a rat study to characterize baclofen-induced encephalopathy, correlate its severity with plasma concentrations and investigate the contribution of tolerance...
May 18, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29782960/the-acute-and-residual-effects-of-escalating-analgesic-range-doses-of-ketamine-on-driving-performance-a-simulator-study
#16
Amie C Hayley, Maja Green, Luke A Downey, Con K K Stough, Michael Keane, Brook Shiferaw, Panagiota Kostakis, Yahya Shehabi
Ketamine hydrochloride elicits potent psychotomimetic and neurobehavioural effects which make it incompatible with driving; however, the direct effect on driving performance is yet to be assessed. Using an open label, within-subjects protocol, 15 males and 5 females (mean age = 30.8 years) were administered three fixed, stepwise increasing sub-anaesthetic doses of intravenous (IV) ketamine solution [(i) 8 mg/h IV infusion plus 30 mg bolus, (ii) 12 mg/h IV infusion and (iii) 20 mg/h infusion]. Whole blood ketamine and norketamine concentrations were determined at each treatment step and at 2 h post-infusion...
May 18, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29782958/changes-in-behavioural-parameters-oxidative-stress-and-neurotrophins-in-the-brain-of-adult-offspring-induced-to-an-animal-model-of-schizophrenia-the-effects-of-fa-deficient-or-fa-supplemented-diet-during-the-neurodevelopmental-phase
#17
L Canever, T G Freire, G A Mastella, L Damázio, S Gomes, I Fachim, C Michels, G Carvalho, A K Godói, B R Peterle, F F Gava, S Valvassori Sda, J Budni, J Quevedo, A I Zugno
A deficiency of maternal folic acid (FA) can compromise the function and development of the brain, and may produce a susceptibility to diseases such as schizophrenia (SZ) in the later life of offspring. The aim of this study was to evaluate the effects of both FA deficient and FA supplemented diets during gestation and lactation on behavioural parameters, the markers of oxidative stress and neurotrophic factors in adult offspring which had been subjected to an animal model of SZ. Female mother rats (Dam's) were separated into experimental maternal groups, which began receiving a special diet (food) consisting of the AIN-93 diet, a control diet, or an FA deficient diet during the periods of pregnancy and lactation...
May 18, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29782943/effects-of-d-amphetamine-on-risk-choice-in-rats-depend-on-the-manner-in-which-the-expected-reward-value-is-varied
#18
Jen-Hau Yang, Chung-Ping Cheng, Ruey-Ming Liao
Decision making related to risks and rewards has been studied in the rodent by using several behavioral tests including the use of probability discounting tasks. However, it still remains unclear how long-term values and the different levels of risk are involved in decisions with reward uncertainty. In this study, we used a T-maze choice task to investigate the role of expected reward values in decision making under risk in the rat. The task was specifically set up to run with the expected value (EV) being equal to 1 between binary choice options (small-and-certain vs...
May 18, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29782929/coated-platelets-introduce-significant-delay-in-onset-of-peak-thrombin-production-theoretical-predictions
#19
M Susree, Mikhail A Panteleev, M Anand
Platelets play a crucial role in the initiation, progress, termination as well as regulation of blood coagulation. Recent studies have confirmed that not all but only a small percentage of thrombin-activated platelets ("coated" platelets) exhibit procoagulant properties (namely the expression of phosphatidylserine binding sites) required for the acceleration and progress of coagulation. A mechanistic model is developed for in vitro coagulation whose key features are distinct equations for coated platelets, thrombin dose-dependence for coated platelets, and competitive binding of coagulation factors to platelet membrane...
May 18, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29782913/statewide-collaborative-to-reduce-surgical-site-infection-results-of-the-hawaii-surgical-unit-based-safety-program
#20
Della M Lin, Kathryn A Carson, Lisa H Lubomski, Elizabeth C Wick, Julius Cuong Pham
BACKGROUND: Surgical Site Infections (SSI) after colorectal surgery are common, lead to patient harm, and are costly to the healthcare system. This study's purpose was to evaluate the effectiveness of the Agency for Healthcare Research and Quality (AHRQ) Safety Program for Surgery in Hawaii. STUDY DESIGN: This pre-post cohort study involved 100% of 15 hospitals in Hawaii from January 2013-June 2015. The intervention was a statewide implementation of the Comprehensive-Unit-based-Safety-Program (CUSP) and individualized bundles of interventions to reduce SSI...
May 3, 2018: Journal of the American College of Surgeons
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