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https://www.readbyqxmd.com/read/28737942/the-role-of-rydberg-valence-coupling-in-the-ultrafast-relaxation-dynamics-of-acetone
#1
Markus Koch, Bernhard Thaler, Pascal Heim, Wolfgang E Ernst
The electronic structure of excited states of acetone is represented by a Rydberg manifold that is coupled to valence states which provide very fast and efficient relaxation pathways. We observe and characterize the transfer of population from photoexcited Rydberg states (6p, 6d, 7s) to a whole series of lower Rydberg states (3p to 4d) and a simultaneous decay of population from these states. We obtain these results with time-resolved photoelectron-photoion coincidence (PEPICO) detection in combination with the application of Bayesian statistics for data analysis...
July 24, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28737278/multicellular-vascularized-engineered-tissues-through-user-programmable-biomaterial-photodegradation
#2
Christopher K Arakawa, Barry A Badeau, Ying Zheng, Cole A DeForest
A photodegradable material-based approach to generate endothelialized 3D vascular networks within cell-laden hydrogel biomaterials is introduced. Exploiting multiphoton lithography, microchannel networks spanning nearly all size scales of native human vasculature are readily generated with unprecedented user-defined 4D control. Intraluminal channel architectures of synthetic vessels are fully customizable, providing new opportunities for next-generation microfluidics and directed cell function.
July 24, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28736255/isoalantolactone-derivative-promotes-glucose-utilization-in-skeletal-muscle-cells-and-increases-energy-expenditure-in-db-db-mice-via-activating-ampk-dependent-signaling
#3
Deepti Arha, E Ramakrishna, Anand P Gupta, Amit K Rai, Aditya Sharma, Ishbal Ahmad, Mohammed Riyazuddin, Jiaur R Gayen, Rakesh Maurya, Akhilesh K Tamrakar
Augmenting glucose utilization and energy expenditure in skeletal muscle via AMP-activated protein kinase (AMPK) is an imperative mechanism for the management of type 2 diabetes. Chemical derivatives (2a-2h, 3, 4a-4d, 5) of the isoalantolactone (K007), a bioactive molecule from roots of Inula racemosa were synthesized to optimize the bioactivity profile to stimulate glucose utilization in skeletal muscle cells. Interestingly, 4a augmented glucose uptake, driven by enhanced translocation of glucose transporter 4 (GLUT4) to cell periphery in L6 rat skeletal muscle cells...
July 20, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28735862/transcriptome-analysis-reveals-temperature-regulated-antiviral-response-in-turbot-scophthalmus-maximus
#4
Jian Zhang, Li Sun
Megalocytivirus is a severe pathogen to turbot (Scophthalmus maximus), a popular aquaculture species in many countries. In this study, we investigated the effect of temperature on the antiviral response of turbot at transcriptome level. We found that when turbot were infected with megalocytivirus RBIV-C1 at low temperatures (14 °C, 16 °C, and 18 °C), viral replication was undetectable or moderate and no fish mortality occurred; in contrast, when turbot were infected with RBIV-C1 at high temperatures (20 °C, 22 °C, and 24 °C), viral replication was robust and 100% host mortality was observed...
July 20, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28734927/4-dimensionally-guided-3-dimensional-color-doppler-ultrasonography-quantifies-carotid-artery-stenosis-with-high-reproducibility-and-accuracy
#5
Roland Richard Macharzina, Sascha Kocher, Steven R Messé, Thomas Rutkowski, Fabian Hoffmann, Matthias Vogt, Werner Vach, Nian Fan, Aljoscha Rastan, Franz-Josef Neumann, Thomas Zeller
OBJECTIVES: The purpose was to analyze the agreement and binary accuracy of the degree of internal carotid artery stenosis (ICAS) as determined by 4-dimensionally (4D) real-time gray-scale guided 3-dimensional (3D) color-Doppler ultrasonography (3DC-US) (4D/3DC-US) compared with catheter angiography (CA) and duplex ultrasonography (DUS). This study hypothesized that 4D/3DC-US is noninferior to CA and DUS in grading ICAS in selected patients. BACKGROUND: Clinical stratification in patients with ICAS largely depends on a patient's symptomatic status and the degree of stenosis...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28734317/the-4d-nucleome
#6
EDITORIAL
Thomas Ried, Indika Rajapakse
No abstract text is available yet for this article.
July 1, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28733790/is-a-dragging-sensation-a-symptom-of-female-pelvic-organ-prolapse
#7
Hans Peter Dietz, Candice Chatel, Ixora Kamisan Atan
INTRODUCTION AND HYPOTHESIS: Pelvic organ prolapse (POP) commonly presents with a "vaginal lump or bulge" and/or a "dragging sensation." The first symptom correlates strongly with clinical and imaging data. However, a "dragging sensation" may be less specific. Hence, we investigated the predictive value of both symptoms for POP. METHODS: This was a retrospective study involving archived data sets of women seen between November 2013 and May 2014. All underwent a clinical interview, POPQ examination, and 4D translabial ultrasound (TLUS)...
July 21, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28730811/atomic-mechanism-of-hybridization-dependent-surface-reconstruction-with-tailored-functionality-in-hexagonal-multiferroics
#8
Shiqing Deng, Shaobo Cheng, Changsong Xu, Binghui Ge, Xuefeng Sun, Rong Yu, Wenhui Duan, Jing Zhu
The broken symmetry along with anomalous defect structures and charging conditions at multiferroics surface can alter both crystal structures and electronic configurations, bringing in emergent physical properties. Extraordinary surface states are induced into original mutually-coupled order parameters in such strongly correlated oxides, which flourish in diverse properties, however remain less explored. Here, we report the peculiar surface ferroelectric states and reconfigurable functionalities driven by the relaxation of surface and consequent changes in O-2p and Y-4d orbital (p-d) hybridization within a representative hexagonal multiferroics YMnO3...
July 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28730652/effects-of-collimator-angle-couch-angle-and-starting-phase-on-motion-tracking-dynamic-conformal-arc-therapy-4d-dcat
#9
Zhengzheng Xu, Rutao Yao, Matthew B Podgorsak, Iris Z Wang
PURPOSE: The aim of this study was to find an optimized configuration of collimator angle, couch angle, and starting tracking phase to improve the delivery performance in terms of MLC position errors, maximal MLC leaf speed, and total beam-on time of DCAT plans with motion tracking (4D DCAT). METHOD AND MATERIALS: Nontracking conformal arc plans were first created based on a single phase (maximal exhalation phase) of a respiratory motion phantom with a spherical target...
July 21, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28729434/cohesins-and-condensins-orchestrate-the-4d-dynamics-of-yeast-chromosomes-during-the-cell%C3%A2-cycle
#10
Luciana Lazar-Stefanita, Vittore F Scolari, Guillaume Mercy, Héloise Muller, Thomas M Guérin, Agnès Thierry, Julien Mozziconacci, Romain Koszul
Duplication and segregation of chromosomes involves dynamic reorganization of their internal structure by conserved architectural proteins, including the structural maintenance of chromosomes (SMC) complexes cohesin and condensin. Despite active investigation of the roles of these factors, a genome-wide view of dynamic chromosome architecture at both small and large scale during cell division is still missing. Here, we report the first comprehensive 4D analysis of the higher-order organization of the Saccharomyces cerevisiae genome throughout the cell cycle and investigate the roles of SMC complexes in controlling structural transitions...
July 20, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28729071/transient-transfection-of-intraerythrocytic-babesia-gibsoni-using-elongation-factor-1-alpha-promoter
#11
Mingming Liu, Masahito Asada, Shinuo Cao, Paul Franck Adjou Moumouni, Patrick Vudriko, Artemis Efstratiou, Hassan Hakimi, Tatsunori Masatani, Fujiko Sunaga, Shin-Ichiro Kawazu, Junya Yamagishi, Xuenan Xuan
The development of gene manipulation techniques has been reported in many protozoan parasites over the past few years. However, these techniques have not yet been established for Babesia gibsoni. Here, we report for the first time, the successful transient transfection of B. gibsoni. The plasmid containing the firefly luciferase reporter gene (pBS-ELA) was transfected into B. gibsoni by an AMAXA 4D Nucleofector™ device. Transfection using program FA113 and Lonza buffer SF showed the highest luciferase expression...
July 17, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28727128/transvaginal-six-arm-mesh-opur-in-women-with-apical-pelvic-organ-prolapse-analysis-of-short-term-results-pelvic-floor-ultrasound-evaluation
#12
Tomasz Kluz, Edyta Wlaźlak, Grzegorz Surkont
OBJECTIVES: Analysis of feasibility, efficacy and short-term results after six-arm transvaginal mesh OPUR implantation in women with apical prolapse. MATERIAL AND METHODS: The same surgeon operated all of 39 women using mesh OPUR. Preoperatively patients had a standardized interview and clinical examination. Intraoperative and postoperative complications were analyzed. Postoperative evaluation included standardized interview, clinical examination and standardized pelvic floor ultrasound performed with 2D transvaginal probe and 4D abdominal probe...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28726684/low-dose-4d-cone-beam-ct-via-joint-spatiotemporal-regularization-of-tensor-framelet-and-nonlocal-total-variation
#13
Hao Han, Hao Gao, Lei Xing
Excessive radiation exposure is still a major concern in 4D cone-beam computed tomography (4D-CBCT) due to its prolonged scanning duration. Radiation dose can be effectively reduced by either under-sampling the x-ray projections or reducing the x-ray flux. However, 4D-CBCT reconstruction under such low-dose protocols is prone to image artifacts and noise. In this work, we propose a novel joint regularization-based iterative reconstruction method for low-dose 4D-CBCT. To tackle the under-sampling problem, we employ spatiotemporal tensor framelet (STF) regularization to take advantage of the spatiotemporal coherence of the patient anatomy in 4D images...
July 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28726680/towards-4d-printed-scaffolds-for-tissue-engineering-exploiting-3d-shape-memory-polymers-to-deliver-time-controlled-stimulus-on-cultured-cells
#14
Wim Hendrikson, Jeroen Rouwkema, Federico Clementi, Clemens A van Blitterswijk, Silvia Fare, Lorenzo Moroni
Tissue engineering needs innovative solutions to better fit the requirements of a minimally-invasive approach, providing at the same time instructive cues to cells. The use of shape memory polyurethane has been investigated by producing 4D scaffolds via 3D printing technology. Scaffolds with two different pore network configurations (0/90° and 0/45°) were characterized by dynamic-mechanical analysis (DMA). The thermo-mechanical analysis showed a Tg at about 32 °C (Tg = Ttrans), indicating no influence of the fabrication process on the transition temperature...
July 20, 2017: Biofabrication
https://www.readbyqxmd.com/read/28726519/cancer-stem-cells-cd133-inhibition-and-cytotoxicity-of-certain-3-phenylthiazolo-3-2-a-benzimidazoles-design-direct-synthesis-crystal-study-and-in-vitro-biological-evaluation
#15
Ghada H Al-Ansary, Wagdy M Eldehna, Hazem A Ghabbour, Sara T A Al-Rashood, Khalid A Al-Rashood, Radwa A Eladwy, Abdullah Al-Dhfyan, Maha M Kabil, Hatem A Abdel-Aziz
Cancer stem cells (CSCs) have been objects of intensive study since their identification in 1994. Adopting a structural rigidification approach, a novel series of 3-phenylthiazolo[3,2-a]benzimidazoles 4a-d was designed and synthesised, in an attempt to develop potent anticancer agent that can target the bulk of tumour cells and CSCs. The anti-proliferative activity of the synthesised compounds was evaluated against two cell lines, namely; colon cancer HT-29 and triple negative breast cancer MDA-MB-468 cell lines...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28723825/feasibility-of-conducting-autism-biomarker-research-in-the-clinical-setting
#16
Laura Sices, Katherine Pawlowski, Laura Farfel, Deirdre Phillips, Yamini Howe, David M Cochran, Roula Choueiri, Peter W Forbes, Stephanie J Brewster, Jean A Frazier, Ann Neumeyer, Carolyn Bridgemohan
OBJECTIVE: Recruitment and completion of research activities during regular clinical care has the potential to increase research participation in complex neurodevelopmental disorders. We evaluated the feasibility, and effect on clinical care, of conducting biomarker research within a subspecialty clinical visit for autism spectrum disorder (ASD). METHODS: Children, aged 5 to 10 years, were recruited by providers in ASD clinics at 5 institutions. Biomarkers collected were growth measurements, head circumference, neurologic and dysmorphology examinations, digit ratio (2D:4D) measurement, and platelet serotonin and urinary melatonin sulfate excretion levels...
July 14, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28721492/peristaltic-like-motion-of-the-human-fetal-right-ventricle-and-its-effects-on-fluid-dynamics-and-energy-dynamics
#17
Hadi Wiputra, Guat Ling Lim, Khong Chun Chua, R Nivetha, Sanah Merchant Soomar, Arijit Biwas, Citra Nurfarah Zaini Mattar, Hwa Liang Leo, Choon Hwai Yap
In both adult human and canine, the cardiac right ventricle (RV) is known to exhibit a peristaltic-like motion, where RV sinus (inflow region) contracts first and the infundibulum (outflow region) later, in a wave-like contraction motion. The delay in contraction between the sinus and infundibulum averaged at 15% of the cardiac cycle and was estimated to produce an intra-ventricular pressure difference of 15 mmHg. However, whether such a contractile motion occurs in human fetuses as well, its effects on hemodynamics remains unknown, and are the subject of the current study...
July 18, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28719844/phosphate-functionalized-4-4-armchair-cnts-as-novel-drug-delivery-systems-for-alendronate-and-etidronate-anti-osteoporosis-drugs
#18
Zahra Nikfar, Zahra Shariatinia
The ability of (4,4)-armchair CNT and its three phosphate functionalized forms (CNT-nH2PO4, n=1-3) were evaluated as novel drug delivery systems (DDSs) for the two commercially well-known anti-osteoporosis drugs namely alendronate (AL) and etidronate (ET). For this purpose, the DFT calculations were accomplished at both B3LYP and B3PW91 levels using 6-31g(d) basis set. The binding energy was increased by increasing number of H2PO4 moieties attached on the CNT with the most negative binding energy was measured for the carrier containing three phosphate groups...
July 8, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28717344/biomaterials-for-4d-stem-cell-culture
#19
Amber M Hilderbrand, Elisa M Ovadia, Matthew S Rehmann, Prathamesh M Kharkar, Chen Guo, April M Kloxin
Stem cells reside in complex three-dimensional (3D) environments within the body that change with time, promoting various cellular functions and processes such as migration and differentiation. These complex changes in the surrounding environment dictate cell fate yet, until recently, have been challenging to mimic within cell culture systems. Hydrogel-based biomaterials are well suited to mimic aspects of these in vivo environments, owing to their high water content, soft tissue-like elasticity, and often-tunable biochemical content...
August 2016: Current Opinion in Solid State & Materials Science
https://www.readbyqxmd.com/read/28715806/real-time-volume-contrast-imaging-in-the-a-plane-with-a-four-dimensional-electronic-probe-facilitates-the-evaluation-of-fetal-extremities-in-midtrimester-sonograms
#20
Federica Bellussi, Giuliana Simonazzi, Ginevra Salsi, Francesca Guasina, Gianluigi Pilu
OBJECTIVE: To evaluate the efficiency of real-time volume contrast imaging in the A plane (VCI-A) of fetal extremities, compared with conventional two-dimensional ultrasound (2D). METHODS: This was a randomized controlled trial of 100 patients undergoing midtrimester sonography. The fetal limbs were imaged with either 2D or VCI-A with a four-dimensional (4D) electronic probe. Time required for the examination, number of images stored, and quality of the documentation were compared...
July 18, 2017: Fetal Diagnosis and Therapy
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