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https://www.readbyqxmd.com/read/28213798/digital-rectal-examination-in-the-evaluation-of-rectovaginal-septal-defects
#1
Suneetha Rachaneni, Ixora Kamisan Atan, Ka Lai Shek, Hans Peter Dietz
INTRODUCTION AND HYPOTHESIS: The objective was to evaluate the diagnostic potential of digital rectal examination in the identification of a true rectocele. METHODS: This is a retrospective observational study utilising 187 archived data sets of women presenting with lower urinary tract symptoms and/or pelvic organ prolapse between August 2012 and November 2013. Evaluation included a standardised interview, ICS-POPQ, rectal examination and 4D translabial ultrasound...
February 17, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28211367/high-quality-four-dimensional-cone-beam-ct-reconstruction-using-motion-compensated-total-variation-regularization
#2
Hua Zhang, Jianhua Ma, Zhaoying Bian, Dong Zeng, Qianjin Feng, Wufan Chen
Four dimensional cone-beam computed tomography (4D-CBCT) has great potential clinical value because its ability to describe tumor and organ motion. But the challenge in 4D-CBCT reconstruction is the limited number of projections at each phase, which resulting in the reconstruction full of noise and streak artifacts with the conventional analytical algorithms. To address this problem, in this paper, we propose a motion compensated total variation regularization approach which tries to maximum explore the temporal coherence of the spatial structures among 4D-CBCT phases...
February 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28208851/2d-4d-ratio-and-its-implications-in-medicine
#3
Saravanakumar Jeevanandam, Prathibha K Muthu
Digit ratios, especially 2D:4D ratio, a potential proxy marker for prenatal androgen exposure shows sexual dimorphism. Existing literature and recent research show accumulating evidence on 2D:4D ratio showing correlations with various phenotypic traits in humans. Ratio of 2D:4D is found to correlate negatively to testosterone and positively to oestrogen in the foetus. Interestingly, it is constant since birth and not influenced by the adult hormone levels. Usually, males have lower ratios when compared to females...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208849/finger-length-ratio-2d-4d-in-central-india-and-an-attempt-to-verify-fraternal-birth-order-effect-a-population-based-cross-sectional-study
#4
Arjun Maitra, Chaitali Maitra, Dilip Kumar Jha, Rakesh Biswas
INTRODUCTION: A normal physiology of a human being is not mere a series of functions occurring with specific intensities and timing. There are lot of factors that may change the normal physiological activity within normal limits. Finger length ratio is one of the markers of intrauterine androgen exposure and it is debated and contradicted by many authors. Digit ratio varies among the ethnicities. Many Indian studies show that there is considerable difference in finger length ratio in different population...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208275/comprehensive-three-dimensional-gas-chromatography-with-time-of-flight-mass-spectrometry
#5
Nathanial E Watson, H Daniel Bahaghighat, Ke Cui, Robert E Synovec
Development of comprehensive, three-dimensional (3D) gas chromatography with time-of-flight mass spectrometric detection (GC(3)/TOFMS) is described. This instrument provides four dimensions (4D) of chemical selectivity and includes significant improvements to total selectivity (mass spectrometric and chromatographic), peak identification, and operational temperature range relative to previous models of the GC(3) reported. The new instrumental design and data output are evaluated and illustrated via two samples, a 115-component test mixture and a diesel fuel spiked with several compounds, for the purpose of illustrating the chemical selectivity benefits of this instrumental platform...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28203490/pulsatile-tinnitus-differential-diagnosis-and-radiological-work-up
#6
REVIEW
Sjoert A H Pegge, Stefan C A Steens, Henricus P M Kunst, Frederick J A Meijer
PURPOSE OF REVIEW: Identification of the underlying cause of pulsatile tinnitus is important for treatment decision making and for prognosis estimation. For this, an adequate diagnostic imaging strategy is crucial. RECENT FINDINGS: Both CT and MRI can be useful, and in general, these modalities provide complementary diagnostic information. The scanning protocol can be optimized based on the estimated a priori chance for finding specific pathology, or the need to rule out more rare but clinical significant disease...
2017: Current Radiology Reports
https://www.readbyqxmd.com/read/28202801/molecular-epidemiology-and-strain-comparison-between-hepatitis-e-virus-in-human-sera-and-pig-livers-during-2014-2016-in-hong-kong
#7
Martin C W Chan, Kirsty Kwok, Tin-Nok Hung, Paul K S Chan
Hepatitis E virus (HEV) causes substantial morbidity and mortality in developing countries and is considered an emerging food-borne pathogen in previously non-endemic developed countries. To investigate genetic association between human HEV infection and HEV-contaminated high-risk food in Hong Kong, we compared local virus strains obtained from hepatitis E patient sera with those surveyed from high-risk food items during 2014-2016. Twenty-four cases of laboratory-confirmed human HEV infections were identified from January 2014 to March 2016 in our hospitals...
February 15, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28198353/adsorption-and-migration-of-single-metal-atoms-on-the-calcite-10-4-surface
#8
H Pinto, V Haapasilta, M Lokhandwala, S Öberg, Adam S Foster
Transition metal atoms are one of the key ingredients in the formation of functional 2D metal organic coordination networks. Additionally, the co-deposition of metal atoms can play an important role in anchoring the molecular structures to the surface at room temperature. To gain control of such processes requires the understanding of adsorption and diffusion properties of the different transition metals on the target surface. Here, we used density functional theory to investigate the adsorption of 3d (Ti, Cr, Fe, Ni, Cu), 4d (Zr, Nb, Mo, Pd, Ag) and 5d (Hf, W, Ir, Pt, Au) transition metal adatoms on the insulating calcite (10...
February 15, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28195832/four-dimensional-printing-hierarchy-scaffolds-with-highly-biocompatible-smart-polymers-for-tissue-engineering-applications
#9
Shida Miao, Wei Zhu, Nathan J Castro, Jinsong Leng, Lijie Grace Zhang
The objective of this study was to four-dimensional (4D) print novel biomimetic gradient tissue scaffolds with highly biocompatible naturally derived smart polymers. The term "4D printing" refers to the inherent smart shape transformation of fabricated constructs when implanted minimally invasively for seamless and dynamic integration. For this purpose, a series of novel shape memory polymers with excellent biocompatibility and tunable shape changing effects were synthesized and cured in the presence of three-dimensional printed sacrificial molds, which were subsequently dissolved to create controllable and graded porosity within the scaffold...
October 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28195693/assembly-domain-based-optogenetic-system-for-the-efficient-control-of-cellular-signaling
#10
Akihiro Furuya, Fuun Kawano, Takahiro Nakajima, Yoshibumi Ueda, Moritoshi Sato
We previously developed the Magnet system, which consists of two distinct Vivid protein variants, one positively and one negatively charged, designated the positive Magnet (pMag) and negative Magnet (nMag), respectively. These two proteins bind to each other through electrostatic interactions, preventing unwanted homodimerization and providing selective light-induced heterodimerization. The Magnet system enables the manipulation of cellular functions such as protein-protein interactions and genome editing, although the system could be improved further...
February 14, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28192235/high-hcv-subtype-heterogeneity-in-a-chronically-infected-general-population-revealed-by-high-resolution-hcv-subtyping
#11
Francisco Rodriguez-Frias, Leonardo Nieto, Josep Gregori, Damir Garcia-Cehic, Rosario Casillas, David Tabernero, Maria Homs, Maria Blasi, Marta Vila, Qian Chen, Victor Vargas, Lluís Castells, Lluís Viladomiu, Joan Genesca, Beatriz Minguez, Salvador Augustin, Judit Carbonell, Celia Perales, Maria Eugenia Soria, Miriam Asensio, Meritxell Llorens, Laura Ordeig, Cristina Godoy, Maria Buti, Rafael Esteban, Tomas Pumarola, Juan Ignacio Esteban, Josep Quer
OBJECTIVES: Accurately characterize the chronically-infected general HCV population in the Barcelona area by a highly sensitive subtyping method able to identify the 67 recognized hepatitis C virus (HCV) subtypes, and to discriminate mixed infections in a single individual. This information has strong implications on patient management, in deciding the optimal combination of direct-acting antivirals (DAAs) for each patient. METHODS: HCV subtyping by UDPS. All HCV patients who attended Vall d'Hebron Hospital outpatient clinics from February 2015 to May 2016 (N=1473) were included...
February 10, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28191858/impact-of-the-pde4d-gene-polymorphism-and-additional-snp-snp-and-gene-smoking-interaction-on-ischemic-stroke-risk-in-chinese-han-population
#12
Xianxiang Wang, Zhongwu Sun, Yiquan Zhang, Xuefeng Tian, Qingxin Li, Jing Luo
AIMS: To investigate the association between phosphodiesterase 4D gene (PDE4D) gene single nucleotide polymorphisms (SNPs) and ischemic stroke (IS) risk, and impact of additional SNP- SNP and gene- smoking interaction on IS risk in Chinese population. METHODS: A total of 1228 subjects (666 males, 562 females) were selected, including 610 IS patients and 618 control subjects. Logistic regression model was used to examine the association between SNPs in PDE4D gene and IS risk...
February 13, 2017: Neurological Research
https://www.readbyqxmd.com/read/28190793/4d-ultrasound-imaging-ethically-justifiable-in-india
#13
Venkatraman Indiran
Four-dimensional (4D) ultrasound (real-time volume sonography), which has been used in the West since the last decade for the determination of gender as well as for bonding and entertainment of the parents, has become widely available in India in this decade. Here, I would like to discuss the ethical issues associated with 4D ultrasonography in India. These are self-referral, the use of the technology for non-medical indications, a higher possibility of the disclosure of the foetus' gender and safety concerns...
January 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28187171/anticholinergic-burden-and-cognitive-function-in-a-large-german-cohort-of-hospitalized-geriatric-patients
#14
Barbara Pfistermeister, Thomas Tümena, Karl-Günter Gaßmann, Renke Maas, Martin F Fromm
PURPOSE: Previous studies suggest an association between use of anticholinergic drugs in elderly patients and cognitive impairment. However, there are still limited data on the association of anticholinergic drug use and cognitive impairment as well as contribution of individual drugs to anticholinergic load using large, well-documented patient cohorts treated in geriatric units from Europe. METHODS: We investigated 797,440 prescriptions to 89,579 hospitalized patients treated in geriatric units within the GiB-DAT database...
2017: PloS One
https://www.readbyqxmd.com/read/28185475/4d-flow-magnetic-resonance-imaging-role-in-pediatric-congenital-heart-disease
#15
Claire M Lawley, Kathryn M Broadhouse, Fraser M Callaghan, David S Winlaw, Gemma A Figtree, Stuart M Grieve
Imaging-based evaluation of cardiac structure and function remains paramount in the diagnosis and monitoring of congenital heart disease in childhood. Accurate measurements of intra- and extracardiac hemodynamics are required to inform decision making, allowing planned timing of interventions prior to deterioration of cardiac function. Four-dimensional flow magnetic resonance imaging is a nonionizing noninvasive technology that allows accurate and reproducible delineation of blood flow at any anatomical location within the imaging volume of interest, and also permits derivation of physiological parameters such as kinetic energy and wall shear stress...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28185309/initial-evaluation-of-99m-tc-tricarbonyl-cyclopentadienyl-fatty-acids-derivatives-as-spect-tracers-for-myocardium
#16
Jianping Liu, Huan Wang, Shuxia Wang, Qianqian Xue, Dawei Wang, Wang Hang, Huabei Zhang
Fatty acids are myocardial metabolic agent for detecting myocardial ischemia and infraction. However, no (99m) Tc-labeled fatty acids had potential use in clinical practice. In this study, (99m) Tc-CpTT-10-oxo-para-PPA (1d), (99m) Tc-CpTT-11-oxo-para-PPA (2d), (99m) Tc-CpTT-12-oxo-para-PPA (3d), (99m) Tc-CpTT-11-oxo-ortho-PPA (4d) and (99m) Tc-CpTT-11-oxo-meta-PPA (5d) were synthesized by a double ligand transfer reaction, their biological behaviors were investigated. Compound 2d achieved good heart/blood ratio (3...
February 9, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28184976/decreased-diastolic-ventricular-kinetic-energy-in-young-patients-with-fontan-circulation-demonstrated-by-four-dimensional-cardiac-magnetic-resonance-imaging
#17
Pia Sjöberg, Einar Heiberg, Pär Wingren, Jens Ramgren Johansson, Torsten Malm, Håkan Arheden, Petru Liuba, Marcus Carlsson
Four-dimensional (4D) flow magnetic resonance imaging (MRI) enables quantification of kinetic energy (KE) in intraventricular blood flow. This provides a novel way to understand the cardiovascular physiology of the Fontan circulation. In this study, we aimed to quantify the KE in functional single ventricles. 4D flow MRI was acquired in eleven patients with Fontan circulation (median age 12 years, range 3-29) and eight healthy volunteers (median age 26 years, range 23-36). Follow-up MRI after surgical or percutaneous intervention was performed in 3 patients...
February 10, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28177019/predicting-bond-dissociation-energy-and-bond-length-for-bimetallic-diatomic-molecules-a-challenge-for-electronic-structure-theory
#18
Junwei Lucas Bao, Xin Zhang, Xuefei Xu, Donald G Truhlar
Accurately predicting bond length and bond dissociation energy for bimetallic diatomic molecules that involve metal-metal multiple bonds is a great challenge for electronic structure theory, in part because many of these molecules have inherently multi-configuration wave functions, a characteristic that is variously labeled as strong correlation or multireference character. Although various popular density functionals are widely used in studying metal-metal bonding in catalysis, their accuracy can be questioned, and it is important to see both how well and how poorly a functional can perform...
February 8, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28174322/4d-microvascular-analysis-reveals-that-regenerative-angiogenesis-in-ischemic-muscle-produces-a-flawed-microcirculation
#19
John-Michael Arpino, Zengxuan Nong, Fuyan Li, Hao Yin, Nour W Ghonaim, Stephanie Milkovich, Brittany Balint, Caroline O'Neil, Graham M Fraser, Daniel Goldman, Christopher G Ellis, J G Pickering
RATIONALE: Angiogenesis occurs following ischemic injury to skeletal muscle and enhancing this response has been a therapeutic goal. However, to appropriately deliver oxygen, a precisely organized and exquisitely responsive microcirculation must form. Whether these network attributes exist in a regenerated microcirculation is unknown and methodologies for answering this have been lacking. OBJECTIVE: To develop 4D methodologies for elucidating microarchitecture and function of the reconstructed microcirculation in skeletal muscle...
February 7, 2017: Circulation Research
https://www.readbyqxmd.com/read/28174097/synthetic-2-aryl-3-piperidin-1-yl-ethyl-thiazolidin-4-ones-exhibit-selective-in%C3%A2-vitro-antitumoral-activity-and-inhibit-cancer-cell-growth-in-a-preclinical-model-of-glioblastoma-multiforme
#20
Elita F da Silveira, Juliana H Azambuja, Taíse Rosa de Carvalho, Alice Kunzler, Daniel S da Silva, Fernanda C Teixeira, Rodrigo Rodrigues, Fátima T Beira, Rita de Cássia Sant Anna Alves, Roselia M Spanevello, Wilson Cunico, Francieli M Stefanello, Ana P Horn, Elizandra Braganhol
Glioblastoma multiforme (GBM) is the worst form of primary brain tumor, which has a high rate of infiltration and resistance to radiation and chemotherapy, resulting in poor prognosis for patients. Recent studies show that thiazolidinones have a wide range of pharmacological properties including antimicrobial, anti-inflammatory, anti-oxidant and anti-tumor. Here, we investigate the effect antiglioma in vitro of a panel of sixteen synthetic 2-aryl-3-((piperidin-1-yl)ethyl)thiazolidin-4-ones where 13 of these decreased the viability of glioma cells 30-65% (100 μM) compared with controls...
February 4, 2017: Chemico-biological Interactions
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