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https://www.readbyqxmd.com/read/27926660/radioembolization-induced-liver-disease-a-systematic-review
#1
Manon N G J A Braat, Karel J van Erpecum, Bernard A Zonnenberg, Maurice A J van den Bosch, Marnix G E H Lam
Radioembolization (RE) is a relatively novel treatment modality for primary and secondary hepatic malignancies. Microspheres embedded with a β-emitting radioisotope are injected into the hepatic artery, resulting in microsphere deposition in the tumor arterioles and normal portal triads. Microsphere deposition in nontumorous parenchyma can result in radiation-induced liver injury, with lethal RE-induced liver disease (REILD) at the outer end of the spectrum. The primary aim of this study was to evaluate RE-related hepatotoxicity and present an overview of the currently applied definitions and clinically relevant characteristics of REILD...
December 6, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27925376/animated-activity-questionnaire-aaq-a-new-method-of-self-reporting-activity-limitations-in-patients-with-hip-and-knee-osteoarthritis-comparisons-with-observation-by-spouses-for-construct-validity
#2
W F Peter, H S Dagfinrud, N Østerås, C B Terwee
OBJECTIVE: The aim of the present study was to evaluate the construct validity of the Animated Activity Questionnaire (AAQ) for measuring activity limitations of patients with hip and knee osteoarthritis (HKOA). DESIGN: In a psychometric design, data from HKOA patients and their spouses in Norway and the Netherlands were collected independently of each other, using the AAQ, the Function of Daily Living (FDL) subscale from the Hip disability or Knee injury Osteoarthritis Outcome Scale (H/KOOS) and the Numerical Rating Scale for pain (NRS-pain)...
December 7, 2016: Musculoskeletal Care
https://www.readbyqxmd.com/read/27924167/reduction-of-falls-and-factors-affecting-falls-a-year-after-total-knee-arthroplasty-in-elderly-patients-with-severe-knee-osteoarthritis
#3
T Tsonga, M Michalopoulou, S Kapetanakis, E Giovannopoulou, P Malliou, G Godolias, P Soucacos
BACKGROUND: Total Knee Arthroplasty (TKA) is a common surgical treatment for severe knee Osteoarthritis (OA), which generally improves pain, physical function, quality of life and possibly fall risk. Fall risk increases for older adults with severe knee OA; however it has not been studied extensively whether this parameter is improved after TKA. OBJECTIVE: To investigate: a) the history and frequency of falls, including mechanism or causes of falls, injuries sustained from falls reported, activity during falling and location of falls and, b) the factors affecting falls, a year after TKA in elderly patients with severe knee OA...
2016: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/27924147/self-harm-in-child-and-adolescent-psychiatric-inpatients-a-retrospective-study
#4
Naista Zhand, Katherine Matheson, Darren Courtney
OBJECTIVE: This study presents a comprehensive report of children and adolescents who engaged in self-harm during their admission to a psychiatric inpatient unit. METHOD: A chart review was conducted on all admissions to an acute care psychiatric inpatient unit in a Canadian children's hospital over a one-year period. Details on patients with self-harm behaviour during the admission were recorded, including: demographics, presentation to hospital, self-harm behaviour and outcome...
2016: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27923779/a-multidisciplinary-model-to-guide-employment-outcomes-among-people-living-with-spinal-cord-injuries-in-south-africa-a-mixed-methods-study-protocol
#5
Ntsikelelo Pefile, Joyce Mothabeng, Saloshni Naidoo
BACKGROUND: Spinal cord injury (SCI) often results in complete or partial loss of functioning of the upper and/or lower limbs, leading to the affected individual experiencing difficulties in performing activities of daily living. This results in reduced participation in social, religious, recreational, and economic activities (employment). The South Africa legal framework promotes the employment and assistance of people with disabilities. However, rehabilitation interventions focus mainly on impairments and activity limitations, with few attempts to prepare those with SCI to return to gainful employment...
December 6, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27923399/ccaat-enhancer-binding-protein-%C3%AE-is-required-for-satellite-cell-self-renewal
#6
Neena Lala-Tabbert, Hamood AlSudais, François Marchildon, Dechen Fu, Nadine Wiper-Bergeron
BACKGROUND: Postnatal growth and repair of skeletal muscle relies upon a population of quiescent muscle precursor cells, called satellite cells that can be activated to proliferate and differentiate into new myofibers, as well as self-renew to replenish the satellite cell population. The balance between differentiation and self-renewal is critical to maintain muscle tissue homeostasis, and alterations in this equilibrium can lead to chronic muscle degeneration. The transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is expressed in Pax7(+) satellite cells of healthy muscle and is downregulated during myoblast differentiation...
December 7, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27922622/the-natural-course-of-spinal-cord-injury-changes-over-40-years-among-those-with-exceptional-survival
#7
J S Krause, J C Newman, J M R Clark, M Dunn
OBJECTIVES: To identify 40-year longitudinal changes in health, activity, employment, life satisfaction and self-rated adjustment after spinal cord injury. STUDY DESIGN: Longitudinal, mailed self-report. METHODS: Participants were identified from outpatient records of a Midwestern USA university hospital in 1973. Follow-ups were conducted in 1984 and approximate 10-year intervals thereafter. A total of 49 participants completed each of the five assessments...
December 6, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27922239/predictors-of-self-esteem-in-adolescents-with-a-psychiatric-referral
#8
Devrim Akdemir, Tuna Çak, Cihan Aslan, Büşra Sultan Aydos, Kevser Nalbant, Füsun Çuhadaroğlu-Çetin
In the literature self-esteem is found to be lower in clinically referred adolescents compared to adolescents without any psychiatric disorder. The aim of this study is to examine self-esteem and associated socio-demographical and psychological factors in clinically referred adolescents in Turkey. Three hundred forty-nine adolescents aged between 12 and 18 years admitted to the Department of Child and Adolescent Psychiatry with a psychiatric complaint were enrolled. Rosenberg Self-Esteem Scale (RSES), Brief Symptom Inventory (BSI), Parenting Style Scale (PSS) and Sense of Identity Assessment Form (SIAF) were used for the evaluation...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27922195/the-neuropeptide-cortistatin-attenuates-experimental-autoimmune-myocarditis-via-inhibition-of-cardiomyogenic-t-cell-driven-inflammatory-responses
#9
Virginia Delgado-Maroto, Clara P Falo, Irene Forte-Lago, Norma Adan, Maria Morell, Elena Maganto-Garcia, Gema Robledo, Francisco O'Valle, Andrew H Lichtman, Elena Gonzalez-Rey, Mario Delgado
BACKGROUND AND PURPOSE: Myocarditis is an inflammatory and autoimmune cardiovascular disease that causes dilated myocardiopathy and is responsible of high morbidity and mortality worldwide. Cortistatin is a neuropeptide produced by neurons and cells of immune and vascular systems. Besides its action in locomotor activity and sleep, cortistatin inhibits inflammation in different experimental models of autoimmune diseases. However, its role in inflammatory cardiovascular disorders is unexplored...
December 6, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27921041/signaling-crosstalk-between-tubular-epithelial-cells-and-interstitial-fibroblasts-after-kidney-injury
#10
REVIEW
Roderick J Tan, Dong Zhou, Youhua Liu
BACKGROUND: A wide variety of kidney diseases ultimately lead to tubulointerstitial damage. The initial site of injury is usually the renal tubules, with activation of fibroblasts occurring later. Self-limited disease is characterized by transient cellular activation with timed deactivation and ultimately a return to normal functioning, whereas sustained responses characterize chronic disease and the development of irreversible fibrosis. The underlying molecular and cellular mechanisms of this cascade of events remain an area of active research...
October 2016: Kidney Diseases
https://www.readbyqxmd.com/read/27920967/a-comparison-of-descriptive-and-functional-analyses-of-inappropriate-mealtime-behavior
#11
Carrie S W Borrero, Jennie D England, Ben Sarcia, Julia N Woods
In recent years, rather than being used to assess the potential function of a response, descriptive assessment methods have been applied to evaluate potential consequences or contingencies for problem behavior (Borrero, Woods, Borrero, Masler, & Lesser in Journal of Applied Behavior Analysis, 43, 71-88. doi: 10.1901/jaba.2010.43-71, 2010) or to assist with designing baseline conditions to approximate caregiver behavior (Casey et al. in Behavior Modification, 33, 537-558. doi: 10.1177/0145445509341457, 2009)...
December 2016: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/27920085/quality-of-prescribing-of-antipsychotic-medication-for-people-with-intellectual-disability-under-the-care-of-uk-mental-health-services-a-cross-sectional-audit-of-clinical-practice
#12
Carol Paton, Sumera Bhatti, Kiran Purandare, Ashok Roy, Tre Barnes
OBJECTIVES: To determine the prevalence and quality of antipsychotic prescribing for people with intellectual disability (ID). DESIGN: A clinical audit of prescribing practice in the context of a quality improvement programme. Practice standards for audit were derived from relevant, evidence-based guidelines, including NICE. Data were mainly collected from the clinical records, but to determine the clinical rationale for using antipsychotic medication in individual cases, prescribers could also be directly questioned...
December 5, 2016: BMJ Open
https://www.readbyqxmd.com/read/27919771/the-initiation-of-chronic-opioids-a-survey-of-chronic-pain-patients-characterizing-chronic-opioid-use
#13
Catherine E Callinan, Mark D Neuman, Kim E Lacy, Claudia Gabison, Michael A Ashburn
: This study reports the results of a researcher-administered survey with 115 patients receiving chronic opioid therapy (>90 days) to obtain information regarding how chronic opioid therapy was started. Chronic opioids were started following surgery (27.0%; 95% CI:18.5-35.5) or for the treatment of acute injury-related pain (27.0%; 95% CI:18.5-35.5). Many who initiated opioid therapy after surgery reported post-operative complications (61.3%; 95% CI:50.8-71.8) and many with injury-related pain reported follow-up corrective surgery (58...
December 2, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27919428/anxiety-and-comorbid-depression-following-traumatic-brain-injury-in-a-community-based-sample-of-young-middle-aged-and-older-adults
#14
A J Osborn, J L Mathias, A K Fairweather-Schmidt, K J Anstey
BACKGROUND: Anxiety is common following a traumatic brain injury (TBI), but who is most at risk, and to what extent, is not well understood. METHODS: Longitudinal data from a randomly-selected community sample (Wave 1: 7397, Wave 2: 6621 and Wave 3: 6042) comprising three adult cohorts (young: 20-24 years of age, middle-aged: 40-44, older: 60-64), were analysed. The association between TBI history, anxiety and comorbid depression was assessed, controlling for age, sex, marital/employment status, medical conditions, recent life events, alcohol consumption, social support and physical activity...
October 5, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27919376/usability-evaluation-of-the-smart-application-for-youth-with-mtbi
#15
Judith W Dexheimer, Brad G Kurowski, Shilo H Anders, Nicole McClanahan, Shari L Wade, Lynn Babcock
OBJECTIVE: There is a dearth of evidence-based treatments available to address the significant morbidity associated with mild traumatic brain injury (mTBI). To address this gap, we designed a novel user-friendly, web-based application. We describe the preliminary evaluation of feasibility and usability of the application to promote recovery following mTBI in youth, the Self-Monitoring Activity-Restriction and Relaxation Treatment (SMART). SMART incorporates real-time recommendations for individualized symptom management and activity restriction along with training in cognitive-behavioral coping strategies...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27919285/a-randomised-patient-assessor-blinded-sham-controlled-trial-of-external-non-invasive-peripheral-nerve-stimulation-for-chronic-neuropathic-pain-following-peripheral-nerve-injury-en-pens-trial-study-protocol-for-a-randomised-controlled-trial
#16
Selina Johnson, Andreas Goebel, Roberta Richey, Emily Holmes, Dyfrig Hughes
BACKGROUND: Eight percent of people in the UK are estimated to have persistent (chronic) neuropathic pain, and for many there is no effective treatment. Medications are the most common first-line treatment but often have limited benefit or adverse events. Surgical treatments, such as spinal cord stimulation, are then often considered. External non-invasive peripheral nerve stimulation (EN-PENS) is a form of electrical stimulation that involves placing a pen-shaped electrode onto the skin, which can be easily self-administered by patients...
December 6, 2016: Trials
https://www.readbyqxmd.com/read/27919063/predictors-of-low-back-pain-in-nursing-home-workers-after-implementation-of-a-safe-resident-handling-programme
#17
Judith E Gold, Laura Punnett, Rebecca J Gore
OBJECTIVES: Healthcare workers have high rates of low back pain (LBP) related to handling patients. A large chain of nursing homes experienced reduced biomechanical load, compensation claims and costs following implementation of a safe resident handling programme (SRHP). The aim of this study was to examine whether LBP similarly declined and whether it was associated with relevant self-reported occupational exposures or personal health factors. METHODS: Worker surveys were conducted on multiple occasions beginning with the week of first SRHP introduction (baseline)...
November 10, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27919058/lifting-and-exertion-injuries-decrease-after-implementation-of-an-integrated-hospital-wide-safe-patient-handling-and-mobilisation-programme
#18
Jack T Dennerlein, Elizabeth Tucker O'Day, Deborah F Mulloy, Jackie Somerville, Anne M Stoddard, Christopher Kenwood, Erin Teeple, Leslie I Boden, Glorian Sorensen, Dean Hashimoto
OBJECTIVE: With increasing emphasis on early and frequent mobilisation of patients in acute care, safe patient handling and mobilisation practices need to be integrated into these quality initiatives. We completed a programme evaluation of a safe patient handling and mobilisation programme within the context of a hospital-wide patient care improvement initiative that utilised a systems approach and integrated safe patient equipment and practices into patient care plans. METHODS: Baseline and 12-month follow-up surveys of 1832 direct patient care workers assessed work practices and self-reported pain while an integrated employee payroll and injury database provided recordable injury rates collected concurrently at 2 hospitals: the study hospital with the programme and a comparison hospital...
October 25, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27918969/isolating-effects-of-moral-injury-and-low-post-deployment-support-within-the-u-s-military
#19
Claire Houtsma, Lauren R Khazem, Bradley A Green, Michael D Anestis
Suicide rates within U.S. military components, particularly the National Guard, are significantly higher than the general population suicide rate. To better understand and prevent suicide within this population, we must identify mechanisms of risk contributing to these discrepancies. One risk factor relevant to military service is moral injury, a term for experiences that violate one's moral beliefs. Using a series of hierarchical multiple regressions, the current study examined the moderating role of post-deployment social support on the association between moral injury (self-transgressions, other-transgressions, and betrayal) and thwarted belongingness among military personnel...
November 28, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27918673/predictive-indicators-of-overuse-injuries-in-adolescent-endurance-athletes
#20
Daniel Martínez-Silván, Jaime Díaz-Ocejo, Andrew Murray
PURPOSE: To analyse the influence of training exposure and the utility of self-report questionnaires on predicting overuse injuries in adolescent endurance athletes. METHODS: 5 adolescent male endurance athletes (15.7 ± 1.4 yr) from a full-time sports academy answered 2 questionnaires (Recovery Cue; RC-q & Oslo Sports Trauma Research questionnaire; OSTRC-q) on a weekly basis for one season (37 wks) in order to detect (1) signs of overtraining and under-recovery (RC-q) and (2) early symptoms of lower limb injuries (OSTRC-q)...
December 5, 2016: International Journal of Sports Physiology and Performance
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