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https://www.readbyqxmd.com/read/29045904/inkt-cells-orchestrate-a-switch-from-inflammation-to-resolution-of-sterile-liver-injury
#1
Pei Xiong Liew, Woo-Yong Lee, Paul Kubes
After traumatic injury, some cells function as detectors to sense injury and to modulate the local immune response toward a restitution phase by affecting the local cytokine milieu. Using intravital microscopy, we observed that patrolling invariant natural killer T (iNKT) cells were initially excluded from a site of hepatic injury but subsequently were strategically arrested first via self-antigens and then by cytokines, circumscribing the injured site at exactly the location where monocytes co-localized and hepatocytes proliferated...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29044679/predictors-of-long-term-bladder-management-in-spinal-cord-injury-patients-upper-extremity-function-may-matter-most
#2
Dimitar V Zlatev, Kazuko Shem, Christopher S Elliott
INTRODUCTION: Clean intermittent catheterization (CIC) is the gold standard for neurogenic bladder management in most patients with spinal cord injury (SCI). There is nonetheless a lack of long-term adherence to CIC, with up to 50% discontinuance at 5-year follow-up. We hypothesize that limitations in upper extremity (UE) motor function represent a strong predictor for long-term CIC adoption. METHODS: We assessed Forms I and II data from the 2000-2013 National SCI Database...
October 17, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29043086/hepatitis-b-vaccination-coverage-and-the-determinants-of-vaccination-among-health-care-workers-in-selected-health-facilities-in-lusaka-district-zambia-an-exploratory-study
#3
Namwaka Mungandi, Mpundu Makasa, Patrick Musonda
BACKGROUND: Hepatitis B is a viral infection of the liver and causes both acute and chronic disease. It is transmitted through contact with an infected person's bodily fluids. It is an occupational hazard for healthcare workers and can be prevented by the administration of a vaccine. It is recommended that healthcare workers be vaccinated against vaccine preventable diseases including hepatitis B. The study objective was to determine the prevalence and determinants of hepatitis B vaccination among healthcare workers in selected health facilities in Lusaka...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29042341/pain-self-management-for-veterans-development-and-pilot-test-of-a-stage-based-mobile-optimized-intervention
#4
Sara S Johnson, Deborah A Levesque, Lynne E Broderick, Dustin G Bailey, Robert D Kerns
BACKGROUND: Chronic pain is a significant public health burden affecting more Americans than cardiovascular disease, diabetes, and cancer combined. Veterans are disproportionately affected by chronic pain. Among previously deployed soldiers and veterans, the prevalence of chronic pain is estimated between 44% and 60%. OBJECTIVE: The objective of this research was to develop and pilot-test Health eRide: Your Journey to Managing Pain, a mobile pain self-management program for chronic musculoskeletal pain for veterans...
October 17, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29042243/extracellular-self-dna-as-a-damage-associated-molecular-pattern-damp-that-triggers-self-specific-immunity-induction-in-plants
#5
Dalia Duran-Flores, Martin Heil
Mammals sense self or non-self extracellular or extranuclear DNA fragments (hereinafter collectively termed eDNA) as indicators of injury or infection and respond with immunity. We hypothesised that eDNA acts as a damage-associated molecular pattern (DAMP) also in plants and that it contributes to self versus non-self discrimination. Treating plants and suspension-cultured cells of common bean (Phaseolus vulgaris) with fragmented self eDNA (obtained from other plants of the same species) induced early, immunity-related signalling responses such as H2O2 generation and MAPK activation, decreased the infection by a bacterial pathogen (Pseudomonas syringae) and increased an indirect defence to herbivores (extrafloral nectar secretion)...
October 14, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29041955/pluripotent-nontumorigenic-multilineage-differentiating-stress-enduring-cells-muse-cells-a-seven-year-retrospective
#6
REVIEW
Samantha C Fisch, María L Gimeno, Julia D Phan, Ariel A Simerman, Daniel A Dumesic, Marcelo J Perone, Gregorio D Chazenbalk
Multilineage differentiating stress enduring (Muse) cells, discovered in the spring of 2010 at Tohoku University in Sendai, Japan, were quickly recognized by scientists as a possible source of pluripotent cells naturally present within mesenchymal tissues. Muse cells normally exist in a quiescent state, singularly activated by severe cellular stress in vitro and in vivo. Muse cells have the capacity for self-renewal while maintaining pluripotent cell characteristics indicated by the expression of pluripotent stem cell markers...
October 18, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29041954/combined-cognitive-and-vocational-interventions-after-mild-to-moderate-traumatic-brain-injury-study-protocol-for-a-randomized-controlled-trial
#7
Emilie I Howe, Knut-Petter S Langlo, Hans Christoffer Aargaard Terjesen, Cecilie Røe, Anne-Kristine Schanke, Helene L Søberg, Unni Sveen, Eline Aas, Heidi Enehaug, Daniele E Alves, Pål Klethagen, Kjersti Sagstad, Christine M Moen, Karin Torsteinsbrend, Anne-Margrethe Linnestad, Tonje Haug Nordenmark, Birte Sand Rismyhr, Grete Wangen, Juan Lu, Jennie Ponsford, Elizabeth W Twamley, Helene Ugelstad, Øystein Spjelkavik, Marianne Løvstad, Nada Andelic
BACKGROUND: A considerable proportion of patients with mild to moderate traumatic brain injury (TBI) experience long-lasting somatic, cognitive, and emotional symptoms that may hamper their capacity to return to work (RTW). Although several studies have described medical, psychological, and work-related factors that predict RTW after TBI, well-controlled intervention studies regarding RTW are scarce. Furthermore, there has traditionally been weak collaboration among health-related rehabilitation services, the labor and welfare sector, and workplaces...
October 17, 2017: Trials
https://www.readbyqxmd.com/read/29040244/a-prospective-study-of-the-causes-of-bruises-in-premobile-infants
#8
Kenneth W Feldman, Tricia M Tayama, Leslie E Strickler, Lee A Johnson, Gauri Kolhatkar, Catherine A DeRidder, Dana C Matthews, Robert Sidbury, James A Taylor
OBJECTIVE: This study had 2 objectives. First, to determine the behavior of physicians evaluating premobile infants with bruises. Second, and most importantly, to learn whether infants with unexplained bruising who had been initially evaluated by primary care and emergency department (ED) physicians are as likely to have their bruises attributed to child abuse as those children evaluated by child abuse physicians. METHODS: Primary care, ED, and child abuse pediatricians (CAPs) in King County, Washington, San Mateo, Calif, Albuquerque, NM, La Crosse, Wis, and Torrance, Calif prospectively identified and studied infants younger than 6 months with less than 6 bruises, which were judged by the evaluating clinician to be explained or unexplained after their initial clinical examination...
October 16, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29039446/protective-effect-of-autophagy-in-neural-ischemia-and-hypoxia-negative-regulation-of-the-wnt-%C3%AE-catenin-pathway
#9
Zhen-Yu Shi, Jie-Xin Deng, Su Fu, Lai Wang, Qiang Wang, Bin Liu, Yong-Qiang Li, Jin-Bo Deng
Autophagy is a highly conserved process of self-digestion to promote cell survival in response to nutrient starvation and other metabolic stresses. However, whether ischemic-hypoxic (IH) injury-induced autophagy acts as a neuroprotective mechanism or leads to neuroinjury is a subject of debate. It is known that autophagy is regulated by signaling pathways, including the mammalian target of rapamycin pathway. However, in neural IH injury, whether other signaling pathways are involved in the regulation of autophagy remains to be fully elucidated...
September 28, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29038367/a-nonimmune-function-of-t-cells-in-promoting-lung-tumor-progression
#10
Jesse A Green, Nicholas Arpaia, Michail Schizas, Anton Dobrin, Alexander Y Rudensky
The involvement of effector T cells and regulatory T (T reg) cells in opposing and promoting solid organ carcinogenesis, respectively, is viewed as a shifting balance between a breach versus establishment of tolerance to tumor or self-antigens. We considered that tumor-associated T cells might promote malignancy via distinct mechanisms used by T cells in nonlymphoid organs to assist in their maintenance upon injury or stress. Recent studies suggest that T reg cells can participate in tissue repair in a manner separable from their immunosuppressive capacity...
October 16, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29037467/cross-cultural-adaptation-and-refinement-of-an-english-version-of-a-dutch-patient-reported-questionnaire-for-hand-sensitivity-the-radboud-evaluation-of-sensitivity
#11
Tara L Packham, Joy C MacDermid, Susan Michlovitz, Edith Cup, Lucelle Van de Ven-Stevens
STUDY DESIGN: Longitudinal clinical measurement. INTRODUCTION: Sensory alterations in the hand can present as both decreased sensation or numbness, and hyperesthesia, including mechanical allodynia and cold intolerance. However, few patient-reported outcomes have been developed and validated for evaluation, particularly for increased sensitivity. The Radboud Evaluation of Sensitivity was developed in the Netherlands for patient-reported evaluation of hand sensitivity in complex regional pain syndrome...
October 13, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29037112/peer-led-transformative-learning-approaches-increase-classroom-engagement-in-care-self-management-classes-during-inpatient-rehabilitation-of-individuals-with-spinal-cord-injury
#12
Julie Gassaway, Michael L Jones, W Mark Sweatman, Tamara Young
OBJECTIVE: Evaluate effects of revised education classes on classroom engagement during inpatient rehabilitation for individuals with spinal cord injury/disease (SCI/D). DESIGN: Multiple-baseline, quasi-experimental design with video recorded engagement observations during conventional and revised education classes; visual and statistical analysis of difference in positive engagement responses observed in classes using each approach. PARTICIPANTS/SETTING: 81 patients (72% male, 73% white, mean age 36 SD 15...
October 16, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29036872/factors-influencing-the-occupational-injuries-of-physical-therapists-in-taiwan-a-hierarchical-linear-model-approach
#13
Yu-Hui Tao, Yu-Lung Wu, Wan-Yun Huang
BACKGROUND: The evidence literature suggests that physical therapy practitioners are subjected to a high probability of acquiring work-related injuries, but only a few studies have specifically investigated Taiwanese physical therapy practitioners. OBJECTIVE: This study was conducted to determine the relationships among individual and group hospital-level factors that contribute to the medical expenses for the occupational injuries of physical therapy practitioners in Taiwan...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036842/investigating-the-discrepancy-between-subjective-and-objective-cognitive-impairment-following-acquired-brain-injury-the-role-of-psychological-affect
#14
Christopher Byrne, Rudi Coetzer, Karen Addy
BACKGROUND: Previous research examining the use of self-reported cognitive impairment as a reliable predictor of actual objective cognitive impairment (OCI) has provided mixed results. OBJECTIVE: The current study aimed to examine the potential discrepancy between subjective and objective cognitive impairment in a sample of individuals with an acquired brain injury (ABI). METHOD: Twenty-four participants, recruited from a community brain injury service, completed an objective neuropsychological assessment and a series of self-report questionnaires assessing psychological affect and perceived cognitive difficulties...
October 8, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29035977/long-term-safety-of-using-local-anesthetic-injections-in-professional-rugby-league-for-modified-indications
#15
Safaa Sebak, John W Orchard, Leigh D Golding, Elizabeth Steet, Steph A Brennan, Ameer Ibrahim
OBJECTIVE: To assess and evaluate the long-term safety of local anesthetic injections before or during games in professional rugby league players. DESIGN: Retrospective case series; Level of evidence, 4. SETTING: Professional rugby league team. PARTICIPANTS: Sydney Roosters players over a 6-year period (2008-2013), who had been administered a local anesthetic injection for an injury before or during a match to aid return to play...
October 5, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29035924/rotational-therapy-in-thoracic-injuries-what-is-the-evidence
#16
Philipp Störmann, Ingo Marzi, Sebastian Wutzler
PURPOSE OF REVIEW: To review the current use of continuous lateral rotational therapy (CLRT) in patients with thoracic injuries and its impact on clinical course, complications and outcome. RECENT FINDINGS: Patient positioning is a key factor in the treatment of severe thoracic injuries and CLRT, and intermittent supine and prone position are basic options. There is a lack of randomized controlled studies for trauma patients with chest injury undergoing kinetic therapy as standard of care...
October 14, 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29035623/the-impact-of-knee-injury-history-on-health-related-quality-of-life-in-adolescent-athletes
#17
Kenneth C Lam, Jessica G Markbreiter
CONTEXT: Current evidence suggests that, despite returning to full participation, physically active adults with a previous knee injury experience lower health-related quality of life (HRQOL) than those with no knee injury history. It is unknown if this relationship is present in adolescent athletes. OBJECTIVE: To determine the impact of knee injury history on HRQOL in adolescent athletes who were medically cleared for full participation. DESIGN: Cross-sectional...
October 16, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29035574/a-6-month-open-label-extension-study-of-vortioxetine-in-pediatric-patients-with-depressive-or-anxiety-disorders
#18
Robert L Findling, Adelaide S Robb, Melissa P DelBello, Michael Huss, Nora K McNamara, Elias H Sarkis, Russell E Scheffer, Lis H Poulsen, Grace Chen, Ole M Lemming, Philippe Auby
OBJECTIVES: In this 6-month open-label extension (OLE) of NCT01491035 (a 14-day, open-label, pharmacokinetic/safety lead-in study), the long-term safety and tolerability of vortioxetine (5-20 mg/day) were investigated in children and adolescents with a DSM-IV-TR™ diagnosis of depressive or anxiety disorder in the United States or Germany. The study also was designed to provide data to inform dose selection and titration in future pediatric studies with vortioxetine. METHODS: Safety evaluations included spontaneously reported adverse events (AEs), the Columbia Suicide Severity Rating Scale (C-SSRS), and the Pediatric Adverse Events Rating Scale (PAERS; clinician administered)...
October 16, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29035068/effects-of-animal-assisted-therapy-on-concentration-and-attention-span-in-patients-with-acquired-brain-injury-a-randomized-controlled-trial
#19
Vanya Gocheva, Margret Hund-Georgiadis, Karin Hediger
OBJECTIVE: Previous studies have reported that brain-injured patients frequently suffer from cognitive impairments such as attention and concentration deficits. Numerous rehabilitation clinics offer animal-assisted therapy (AAT) to address these difficulties. The authors' aim was to investigate the immediate effects of AAT on the concentration and attention span of brain-injured patients. METHOD: Nineteen patients with acquired brain injury were included in a randomized, controlled, within-subject trial...
October 16, 2017: Neuropsychology
https://www.readbyqxmd.com/read/29035067/executive-functioning-in-relation-to-coping-in-mild-versus-moderate-severe-traumatic-brain-injury
#20
Sandra E Rakers, Myrthe E Scheenen, Herma J Westerhof-Evers, Myrthe E de Koning, Harm J van der Horn, Joukje van der Naalt, Jacoba M Spikman
OBJECTIVE: To examine associations between executive functioning (EF) and coping styles, separately for mild and moderate-severe traumatic brain injury (TBI) in the chronic phase postinjury. METHOD: Patients with mild (n = 47) and moderate-severe TBI (n = 59) were included, in addition to healthy controls (HCs; n = 51). Assessment consisted of EF tests (Trail Making Test, Zoo Map Test, Controlled Oral Word Association Test) and questionnaires examining EF (Dysexecutive Questionnaire) and coping styles (Utrecht Coping List)...
October 16, 2017: Neuropsychology
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