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https://www.readbyqxmd.com/read/29679680/ns6740-an-%C3%AE-7-nicotinic-acetylcholine-receptor-silent-agonist-disrupts-hippocampal-synaptic-plasticity
#1
Roger L Papke, Can Peng, Ashok Kumar, Clare Stokes
Long-term potentiation (LTP) in the dentate gyrus was previously shown to be enhanced by nicotine, an effect dependent on both homomeric α7 and heteromeric α2β2 nicotinic acetylcholine receptors (nAChR). In our experiments, bath-applied nicotine produced no significant enhancement of LTP. The α7 nAChR silent agonist NS6740, a weak activator of α7 nAChR ion channels but an effective modulator of the cholinergic anti-inflammatory pathway, decreased LTP and, additionally, produced a substantial reduction in the baseline synaptic function prior to the high frequency stimulation used to induce LTP...
April 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29675583/do-alcohol-related-ampa-type-glutamate-receptor-adaptations-promote-intake
#2
F Woodward Hopf, Regina A Mangieri
Ionotropic glutamate receptors (AMPA, NMDA, and kainate receptors) play a central role in excitatory glutamatergic signaling throughout the brain. As a result, functional changes, especially long-lasting forms of plasticity, have the potential to profoundly alter neuronal function and the expression of adaptive and pathological behaviors. Thus, alcohol-related adaptations in ionotropic glutamate receptors are of great interest, since they could promote excessive alcohol consumption, even after long-term abstinence...
April 20, 2018: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29668918/glutamatergic-signaling-drives-ketamine-mediated-response-in-depression-evidence-from-dynamic-causal-modeling
#3
Jessica R Gilbert, Julia S Yarrington, Kathleen E Wills, Allison C Nugent, Carlos A Zarate
Background: The glutamatergic modulator ketamine has rapid antidepressant effects in individuals with major depressive disorder (MDD) and bipolar depression. Thus, modulating glutamatergic transmission may be critical to effectively treating depression, though the mechanisms by which this occurs are not fully understood. Methods: This double-blind, crossover, placebo-controlled study analyzed data from 18 drug-free MDD subjects and 18 heathy controls who received a single intravenous infusion of ketamine hydrochloride (0...
April 13, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29667304/inhibition-of-alpha7-nicotinic-receptors-in-the-ventral-hippocampus-selectively-attenuates-reinstatement-of-morphine-conditioned-place-preference-and-associated-changes-in-ampa-receptor-binding
#4
Victoria L Wright, Polymnia Georgiou, Alexis Bailey, David J Heal, Christopher P Bailey, Susan Wonnacott
Recurrent relapse is a major problem in treating opiate addiction. Pavlovian conditioning plays a role in recurrent relapse whereby exposure to cues learned during drug intake can precipitate relapse to drug taking. α7 nicotinic acetylcholine receptors (nAChRs) have been implicated in attentional aspects of cognition and mechanisms of learning and memory. In this study we have investigated the role of α7 nAChRs in morphine-conditioned place preference (morphine-CPP). CPP provides a model of associative learning that is pertinent to associative aspects of drug dependence...
April 17, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29666637/recovery-of-chronic-stress-triggered-changes-of-hippocampal-glutamatergic-transmission
#5
Min Lin, Gonglin Hou, Ying Zhao, Ti-Fei Yuan
Chronic stress results in neurochemical, physiological, immune, molecular, cellular, and structural changes in the brain and often dampens the cognition. The hippocampus has been one major focus in studying the stress responsivity and neural mechanisms underlying depression. Both acute and chronic stress stimuli lead to dynamic changes in excitatory transmission in the hippocampus. The present study examined the potential effects of spontaneous recovery after chronic stress on spatial memory function and glutamatergic transmission in the hippocampus...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29666360/signaling-pathways-responsible-for-the-rapid-antidepressant-like-effects-of-a-glun2a-preferring-nmda-receptor-antagonist
#6
Marta Gordillo-Salas, Fuencisla Pilar-Cuéllar, Yves P Auberson, Albert Adell
In a previous study we found that the preferring GluN2A receptor antagonist, NVP-AAM077, elicited rapid antidepressant-like effects in the forced swim test that was related to the release of glutamate and serotonin in the medial prefrontal cortex. In the present work we sought to examine the duration of this behavioral effect as well as the molecular readouts involved. Our results showed that NVP-AAM077 reduced the immobility in the forced swim test 30 min and 24 h after its administration. However, this effect waned 7 days later...
April 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29665633/spatial-glyphosate-and-ampa-redistribution-on-the-soil-surface-driven-by-sediment-transport-processes-a-flume-experiment
#7
Célia P M Bento, Meindert C Commelin, Jantiene E M Baartman, Xiaomei Yang, Piet Peters, Hans G J Mol, Coen J Ritsema, Violette Geissen
This study investigates the influence of small-scale sediment transport on glyphosate and AMPA redistribution on the soil surface and on their off-site transport during water erosion events. Both a smooth surface (T1) and a surface with "seeding lines on the contour" (T2) were tested in a rainfall simulation experiment using soil flumes (1 × 0.5 m) with a 5% slope. A dose of 178 mg m-2 of a glyphosate-based formulation (CLINIC® ) was applied on the upper 0.2 m of the flumes. Four 15-min rainfall events (RE) with 30-min interval in between and a total rainfall intensity of 30 mm h-1 were applied...
March 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29665166/silencing-synaptic-microrna-411-reduces-voluntary-alcohol-consumption-in-mice
#8
Dana Most, Nihal A Salem, Gayatri R Tiwari, Yuri A Blednov, R Dayne Mayfield, R Adron Harris
Chronic alcohol consumption alters the levels of microRNAs and mRNAs in the brain, but the specific microRNAs and processes that target mRNAs to affect cellular function and behavior are not known. We examined the in vivo manipulation of previously identified alcohol-responsive microRNAs as potential targets to reduce alcohol consumption. Silencing of miR-411 by infusing antagomiR-411 into the prefrontal cortex of female C57BL/6J mice reduced alcohol consumption and preference, without altering total fluid consumption, saccharin consumption, or anxiety-related behaviors...
April 17, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29663739/neurotoxic-effects-of-domoic-acid-on-dopaminergic-neurons-in-primary-mesencephalic-cell-culture
#9
Khaled Radad, Mubarak Al-Shraim, Ahmed Al-Emam, Rudolf Moldzio, Wolf-Dieter Rausch
INTRODUCTION: Domoic acid is a potent marine neurotoxin produced by certain species of the diatom genus Pseudonitzschia. To our knowledge, there are no studies that have investigated neurotoxic effects of domoic acid on dopaminergic neurons. Accordingly, the present study was carried out to investigate the potential neurotoxic effects of domoic acid on dopaminergic neurons in primary mesencephalic cell culture. MATERIAL AND METHODS: Cultures prepared from embryonic mouse mesencephala (total of 250 embryos) were treated with different concentrations of domoic acid (0...
2018: Folia Neuropathologica
https://www.readbyqxmd.com/read/29663350/the-role-of-ampa-receptors-and-their-antagonists-in-status-epilepticus
#10
Antonio Leo, Giada Giovannini, Emilio Russo, Stefano Meletti
Status epilepticus (SE) is typically defined as a prolonged self-sustaining seizure or repeated seizures showing an incomplete recovery between them. SE represents a medical emergency often associated with significant disability, morbidity, and mortality. Despite the clinical impact, the mechanisms underlying the transition from self-limited seizures to protracted, medically refractory seizures are not completely understood. About 40% of patients in established SE are refractory to antiepileptic drugs (first-line treatment); therefore, there is a need for more efficacious drugs...
April 17, 2018: Epilepsia
https://www.readbyqxmd.com/read/29663284/fluoxetine-modulates-the-activity-of-hypothalamic-pomc-neurons-via-mtor-signaling
#11
Ilaria Barone, Riccardo Melani, Marco Mainardi, Gaia Scabia, Manuela Scali, Alessia Dattilo, Giovanni Ceccarini, Paolo Vitti, Ferruccio Santini, Lamberto Maffei, Tommaso Pizzorusso, Margherita Maffei
Hypothalamic proopiomelanocortin (POMC) neurons are important players in the regulation of energy homeostasis; we previously demonstrated that environmental stimulation excites arcuate nucleus circuits to undergo plastic remodeling, leading to altered ratio between excitatory and inhibitory synaptic contacts on these neurons. The widely used selective serotonin reuptake inhibitor fluoxetine (FLX) is known to affect body weight. On the other hand, FLX administration mimics the effects of environmental stimulation on synaptic plasticity in the hippocampus and cortex...
April 16, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29662939/ltp-or-ltd-modeling-the-influence-of-stress-on-synaptic-plasticity
#12
Achim Peters, Cordula Reisch, Dirk Langemann
In cognitive memory, long-term potentiation (LTP) has been shown to occur when presynaptic and postsynaptic activities are highly correlated and glucocorticoid concentrations are in an optimal (i.e., low normal) range. In all other conditions, LTP is attenuated or even long-term depression (LTD) occurs. In this paper, we focus on NMDA receptor (NMDA-R)-dependent LTP and LTD, two processes involving various molecular mechanisms. To understand which of these mechanisms are indispensable for explaining the experimental evidence reported in the literature, we here propose a parsimonious model of NMDA-R-dependent synaptic plasticity...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29660891/soil-microbial-communities-and-glyphosate-decay-in-soils-with-different-herbicide-application-history
#13
Keren Hernández Guijarro, Virginia Aparicio, Eduardo De Gerónimo, Martín Castellote, Eva L Figuerola, José Luis Costa, Leonardo Erijman
This study evaluates the glyphosate dissipation under field conditions in three types of soil, and aims to determine the importance of the following factors in the environmental persistence of herbicide: i) soil bacterial communities, ii) soil physicochemical properties, iii) previous exposure to the herbicide. A soil without previous record of GP application (P0) and two agricultural soils, with 5 and >10years of GP exposure (A5 and A10) were subjected to the application of glyphosate at doses of 3mg·kg-1 ...
April 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29627342/blockade-of-%C3%AE-2-adrenergic-or-metabotropic-glutamate-receptors-induces-glutamate-release-in-the-locus-coeruleus-to-activate-descending-inhibition-in-rats-with-chronic-neuropathic-hypersensitivity
#14
Ken-Ichiro Hayashida, Masafumi Kimuram, James C Eisenach
Locus coeruleus (LC)-spinal noradrenergic projections are important to endogenous analgesic mechanisms and can be activated by local glutamate signaling in the LC. The current study examined the local glutamatergic, GABAergic, and noradrenergic influences on glutamate release in the LC and noradrenergic descending inhibition in rats 6 weeks after spinal nerve ligation (SNL). Intra-LC injection of the α2 adrenoceptor antagonist idazoxan or the group 2 metabotropic glutamate receptor (mGluR) antagonist (RS)-α-Methyl-4-tetrazolylphenylglycine (MTPG) increased withdrawal thresholds in SNL animals and this was reversed by the blockade of α-amino-3-hydroxy-5-methyl- 4-isoxazolepropionic acid (AMPA) receptors in the LC or α2-adrenoceptors in the spinal cord, but not in normal animals...
April 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29626166/cascades-of-homeostatic-dysregulation-promote-incubation-of-cocaine-craving
#15
Junshi Wang, Masago Ishikawa, Yue Yang, Mami Otaka, James Y Kim, George R Gardner, Michael T Stefanik, Mike Milovanovic, Yanhua H Huang, Johannes W Hell, Marina E Wolf, Oliver M Schlüter, Yan Dong
In human drug users, cue-induced drug craving progressively intensifies after drug abstinence, promoting drug relapse. This time-dependent progression of drug craving is recapitulated in rodent models, in which rats exhibit progressive intensification of cue-induced drug seeking after withdrawal from drug self-administration, a phenomenon termed incubation of drug craving. While recent results suggest that functional alterations of the nucleus accumbens (NAc) contribute to incubation of drug craving, it remains poorly understood how NAc function evolves after drug withdrawal to progressively intensify drug seeking...
April 6, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29623602/inhibition-of-astrocyte-connexin-43-channels-facilitates-the-differentiation-of-oligodendrocyte-precursor-cells-under-hypoxic-conditions-in-vitro
#16
Qiong Wang, Zhen Wang, Yeye Tian, Huaqiu Zhang, Yongkang Fang, Zhiyuan Yu, Wei Wang, Minjie Xie, Fengfei Ding
Oligodendrocyte precursor cells (OPCs) proliferation and differentiation are essential for remyelination after white matter injury. Astrocytes could promote oligodendrogenesis after white matter damage whereas the underlying mechanisms are unknown. In this study, the role of astrocytic connexin43 (Cx43) hemichannels involved in OPC proliferation and differentiation in chronic hypoxia was evaluated. In an astrocyte-OPC co-culture chronic hypoxia model, OPCs became proliferative but failed to mature into oligodendrocytes...
April 5, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29622647/crmp2-binding-compound-edonerpic-maleate-accelerates-motor-function-recovery-from-brain-damage
#17
Hiroki Abe, Susumu Jitsuki, Waki Nakajima, Yumi Murata, Aoi Jitsuki-Takahashi, Yuki Katsuno, Hirobumi Tada, Akane Sano, Kumiko Suyama, Nobuyuki Mochizuki, Takashi Komori, Hitoshi Masuyama, Tomohiro Okuda, Yoshio Goshima, Noriyuki Higo, Takuya Takahashi
Brain damage such as stroke is a devastating neurological condition that may severely compromise patient quality of life. No effective medication-mediated intervention to accelerate rehabilitation has been established. We found that a small compound, edonerpic maleate, facilitated experience-driven synaptic glutamate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic-acid) receptor delivery and resulted in the acceleration of motor function recovery after motor cortex cryoinjury in mice in a training-dependent manner through cortical reorganization...
April 6, 2018: Science
https://www.readbyqxmd.com/read/29621538/ketamine-and-ketamine-metabolites-as-novel-estrogen-receptor-ligands-induction-of-cytochrome-p450-and-ampa-glutamate-receptor-gene-expression
#18
Ming-Fen Ho, Cristina Correia, James N Ingle, Rima Kaddurah-Daouk, Liewei Wang, Scott H Kaufmann, Richard M Weinshilboum
Major depressive disorder (MDD) is the most common psychiatric illness worldwide, and it displays a striking sex-dependent difference in incidence, with two thirds of MDD patients being women. Ketamine treatment can produce rapid antidepressant effects in MDD patients, effects that are mediated-at least partially-through glutamatergic neurotransmission. Two active metabolites of ketamine, (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-HNK, also appear to play a key role in ketamine's rapid antidepressant effects through the activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors...
April 2, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29618004/the-antidepressant-tianeptine-reverts-synaptic-ampa-receptor-defects-caused-by-deficiency-of-cdkl5
#19
Marco Tramarin, Laura Rusconi, Lara Pizzamiglio, Isabella Barbiero, Diana Peroni, Linda Scaramuzza, Tim Guilliams, David Cavalla, Flavia Antonucci, Charlotte Kilstrup-Nielsen
Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene cause a complex neurological disorder, characterised by infantile seizures, impairment of cognitive and motor skills, and autistic features. Loss of Cdkl5 in mice affects dendritic spine maturation and dynamics but the underlying molecular mechanisms are still far from fully understood. Here we show that Cdkl5 deficiency in primary hippocampal neurons leads to deranged expression of the alpha-amino-3-hydroxy-5-methyl-4-iso-xazole propionic acid receptors (AMPA-R)...
March 30, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29614651/amyloid-%C3%AE-induces-ampa-receptor-ubiquitination-and-degradation-in-primary-neurons-and-human-brains-of-alzheimer-s-disease
#20
Yanmin Zhang, Ouyang Guo, Yuda Huo, Guan Wang, Heng-Ye Man
As the primary mediator for synaptic transmission, AMPA receptors (AMPARs) are crucial for synaptic plasticity and higher brain functions. A downregulation of AMPAR expression has been indicated as one of the early pathological molecular alterations in Alzheimer's disease (AD), presumably via amyloid-β (Aβ). However, the molecular mechanisms leading to the loss of AMPARs remain less clear. We report that in primary neurons, application of Aβ triggers AMPAR internalization accompanied with a decrease in cell-surface AMPAR expression...
January 24, 2018: Journal of Alzheimer's Disease: JAD
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