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Biomechanical engineering

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https://www.readbyqxmd.com/read/28199046/bone-regeneration-in-a-rabbit-critical-femoral-defect-by-means-of-magnetic-hydroxyapatite-macroporous-scaffolds
#1
A Russo, M Bianchi, M Sartori, M Boi, G Giavaresi, D M Salter, M Jelic, M C Maltarello, A Ortolani, S Sprio, M Fini, A Tampieri, M Marcacci
Magnetic scaffolds have recently attracted significant attention in tissue engineering due to the prospect of improving bone tissue formation by conveying soluble factors such as growth factors, hormones, and polypeptides directly to the site of implantation, as well as to the possibility of improving implant fixation and stability. The objective of this study was to compare bone tissue formation in a preclinical rabbit model of critical femoral defect treated either with a hydroxyapatite (HA)/magnetite (90/10 wt %) or pure HA porous scaffolds at 4 and 12 weeks after implantation...
February 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28185928/biologically-active-and-biomimetic-dual-gelatin-scaffolds-for-tissue-engineering
#2
P Sánchez, J L Pedraz, G Orive
We have designed, developed and optimized Genipin cross-linked 3D gelatin scaffolds that were biologically active and biomimetic, show a dual activity both for growth factor and cell delivery. Type B gelatin powder was dissolved in DI water. 100mg of genipin was dissolved in 10ml of DI water. Three genipin concentrations were prepared: 0.1%, 0.2% and 0.3% (w/v). Solutions were mixed at 40°C and under stirring and then left crosslinking for 72h. Scaffolds were obtained by punching 8 mm-cylinders into ethanol 70% solution for 10min and then freeze-drying...
February 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28183629/mechanical-properties-and-in-vivo-study-of-modified-hydroxyapatite-polyetheretherketone-biocomposites
#3
Rui Ma, Qiankuan Li, Lin Wang, Xianghua Zhang, Lin Fang, Zhongkuan Luo, Bai Xue, Lei Ma
Polyether ether ketone (PEEK) has received much attention for its excellent mechanical properties and biocompatibility. Here, the silane coupling agent KH560 [γ-(2,3-epoxypropoxy)propyltrimethoxysilane] is used for graft modification of bioactive HA (hydroxyapatite) particles and for preparing HA/PEEK composites via a hot-press molding method. The prepared HA/PEEK composites were tested for their mechanical properties with SEM (scanning electron microscopy), infrared spectroscopy, and thermo-analysis. The results show that silane coupling KH-560 modifies HA successfully and that the tensile strengths of HA/PEEK and m-HA/PEEK composites indicate an increasing and then a decreasing tendency with increasing HA contents...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183011/semi-degradable-porous-poly-vinyl-alcohol-hydrogel-scaffold-for-cartilage-repair-evaluation-of-the-initial-and-cell-cultured-tribological-properties
#4
Yi Cao, Dangsheng Xiong, Kun Wang, Yuxiang Niu
Tissue engineering for articular cartilage repair has shown success in ensuring the integration of neocartilage with surrounding tissue, but the rapid restoration of biomechanical and biotribological functions remains a significant challenge. Poly (vinyl alcohol) (PVA) hydrogel is regarded as a potential articular cartilage replacement for its fair mechanical strength and low surface friction, while its lack of bioactivity limits its utility. Combining the advantages of tissue engineering materials and PVA hydrogel, we developed a semi-degradable porous PVA hydrogel through addition of ploy (lactic-co-glycolic acid) (PLGA) microspheres and salt-leaching technique...
February 2, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28179518/computational-biomechanics-changes-our-view-on-insect-head-evolution
#5
Alexander Blanke, Peter J Watson, Richard Holbrey, Michael J Fagan
Despite large-scale molecular attempts, the relationships of the basal winged insect lineages dragonflies, mayflies and neopterans, are still unresolved. Other data sources, such as morphology, suffer from unclear functional dependencies of the structures considered, which might mislead phylogenetic inference. Here, we assess this problem by combining for the first time biomechanics with phylogenetics using two advanced engineering techniques, multibody dynamics analysis and finite-element analysis, to objectively identify functional linkages in insect head structures which have been used traditionally to argue basal winged insect relationships...
February 8, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28178627/fundamentals-of-protein-and-cell-interactions-in-biomaterials
#6
REVIEW
Hammed Tanimowo Aiyelabegan, Esmaeil Sadroddiny
The extracellular matrix (ECM) is an active and complex microenvironment with outstanding biomechanical, biophysical, and biochemical characteristics, which can indirectly or directly controls cell adhesion, migration, proliferation, and differentiation, as well as partaking in regeneration and homeostasis of organs and tissues. The ECM has captivated a great deal of attention with the rapid progress of tissue engineering (TE) in the field of regenerative medicine (RM). Approaches to TE, RM and cancer therapy center on the necessity to deliver cell signals to direct cell proliferation and differentiation...
February 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28170430/efficient-decellularization-for-tissue-engineering-of-the-tendon-bone-interface-with-preservation-of-biomechanics
#7
Kai Xu, Lara A Kuntz, Peter Foehr, Katharina Kuempel, Alexandra Wagner, Jutta Tuebel, Constantin V Deimling, Rainer H Burgkart
Interfaces between tendon/ligament and bone ("entheses") are highly specialized tissues that allow for stress transfer between mechanically dissimilar materials. Entheses show very low regenerative capacity resulting in high incidences of failure after surgical repair. Tissue engineering is a promising approach to recover functionality of entheses. Here, we established a protocol to decellularize porcine entheses as scaffolds for enthesis tissue engineering. Chemical detergents as well as physical treatments were investigated with regard to their efficiency to decellularize 2 mm thick porcine Achilles tendon entheses...
2017: PloS One
https://www.readbyqxmd.com/read/28169595/tissue-derived-extracellular-matrix-bioscaffolds-emerging-applications-in-cartilage-and-meniscus-repair
#8
Farrah A Monibi, James Lee Cook
Musculoskeletal injuries are a common and significant problem in orthopaedic practice. Given the long-term consequences of unaddressed cartilage and meniscal pathology, a number of treatments have been attempted to stimulate repair or to replace the injured tissue. Despite advances in orthopaedic surgery, effective treatments for cartilage and meniscus injuries remain a common and significant clinical challenge. Tissue engineering is a developing field that aims to regenerate injured tissues with a combination of cells, scaffolds, and signals...
February 7, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28161466/cmrna-lipoplex-encapsulation-in-plga-microspheres-enables-transfection-via-calcium-phosphate-cement-cpc-plga-composites
#9
Maximilian Utzinger, Anita Jarzebinska, Nicolas Haag, Martin Schweizer, Gerhard Winter, Christian Dohmen, Carsten Rudolph, Christian Plank
In this study lipoplexes containing chemically modified messenger RNA (cmRNA) were incorporated into poly (lactic-co-glycolic acid) (PLGA) microspheres via water-in-oil-in-water (W/O/W) double emulsion solvent evaporation technique. The nanoparticle encapsulation by microparticle formation was optimized to achieve lipoplex release and maximum transfection efficiency in surrounding cells. It was possible to adjust characteristic features in surface topology and size of the PLGA-microspheres by varying the extent of lipoplex loading into the polymer matrix...
February 2, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28135047/biomanufacturing-seamless-tubular-and-hollow-collagen-scaffolds-with-unique-design-features-and-biomechanical-properties
#10
Anirudha Singh, David Lee, Nikolai Sopko, Hotaka Matsui, Praveena Sabnekar, Xiaopu Liu, Jennifer Elisseeff, Mark P Schoenberg, Kenneth Pienta, Trinity J Bivalacqua
A versatile process to develop designer collagen scaffolds for hollow and tubular tissue engineering applications is presented. This process creates seamless and biomechanically tunable scaffolds ranging from ureter-like microsized tubings to structures with highly customized lumens that resemble intestinal villi, fluid bladders, and alveolar sacs that together with stem cells can potentially be used in preclinical and clinical settings.
January 30, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28132525/influence-of-custom-made-implant-designs-on-the-biomechanical-performance-for-the-case-of-immediate-post-extraction-placement-in-the-maxillary-esthetic-zone-a-finite-element-analysis
#11
Jianyu Chen, Zhiguang Zhang, Xianshuai Chen, Xiao Zhang
Due to the increasing adoption of immediate implantation strategies and the rapid development of the computer aided design/computer aided manufacturing technology, a therapeutic concept based on patient-specific implant dentistry has recently been reintroduced by many researchers. However, little information is available on the designs of custom-made dental implant systems, especially their biomechanical behavior. The influence of the custom-made implant designs on the biomechanical performance for both an immediate and a delayed loading protocol in the maxillary esthetic zone was evaluated by means of the finite element (FE) method...
January 29, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28117975/amino-acid-side-chains-buried-along-intersubunit-interfaces-in-a-viral-capsid-preserve-low-mechanical-stiffness-associated-to-virus-infectivity
#12
Pablo Jose P Carrillo, Maria Medrano, Alejandro Valbuena, Alicia Rodríguez-Huete, Milagros Castellanos, Rebeca Pérez, Mauricio G Mateu
Single-molecule experimental techniques and theoretical approaches are revealing that important aspects of virus biology can be understood in biomechanical terms at the nanoscale. A detailed knowledge of the relationship in virus capsids between small structural changes caused by single point mutations, and changes in mechanical properties may provide further physics-based insights into virus function; it may also facilitate the engineering of viral nanoparticles with improved mechanical behavior. Here we used the minute virus of mice to undertake a systematic experimental study on the contribution to capsid stiffness of amino acid side chains at interprotein interfaces and the specific noncovalent interactions they establish...
January 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28117963/chitosan-intercalated-montmorillonite-poly-vinyl-alcohol-nanofibers-as-a-platform-to-guide-neuron-like-differentiation-of-human-dental-pulp-stem-cells
#13
Hatef Ghasemi Hamidabadi, Zahra Rezvani, Maryam Nazm Bojnordi, Haji Shirinzadeh, Alexander M Seifalian, Mohammad Taghi Joghataei, Mojgan Razaghpour, Abbas Alibakhshi, Abolfazl Yazdanpanah, Maryam Salimi, Masoud Mozafari, Aleksandra M Urbanska, Rui L Reis, Subhas C Kundu, Mazaher Gholipourmalekabadi
In this study, we present a novel chitosan-intercalated montmorillonite/Poly(Vinyl alcohol) (OMMT/PVA) nanofibrous mesh as a microenvironment for guiding differentiation of human dental pulp stem cells (hDPSCs) toward neuron-like cells. The OMMT was prepared through ion exchange reaction between the montmorillonite (MMT) and chitosan. The PVA solutions containing various concentrations of OMMT were electrospun to form 3-D OMMT-PVA nanofibrous meshes. The biomechanical and biological characteristics of the nanofibrous meshes were evaluated by ATR-FTIR, XRD, SEM, MTT, LDH specific activity, contact angle, and DAPI staining...
January 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28113232/commentary-on-the-integration-of-model-sharing-and-reproducibility-analysis-to-scholarly-publishing-workflow-in-computational-biomechanics
#14
Ahmet Erdemir, Trent M Guess, Jason Halloran, Luca Modenese, Jeffrey A Reinbolt, Darryl G Thelen, Brian R Umberger
OBJECTIVE: The overall goal of this document is to demonstrate that dissemination of models and analyses for assessing the reproducibility of simulation results can be incorporated in the scientific review process in biomechanics. METHODS: As part of a special issue on model sharing and reproducibility in IEEE Transactions on Biomedical Engineering, two manuscripts on computational biomechanics were submitted: A. Rajagopal et al., IEEE Trans. Biomed. Eng., 2016 and A...
August 24, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28110071/living-nano-micro-fibrous-woven-fabric-hydrogel-composite-scaffolds-for-heart-valve-engineering
#15
Shaohua Wu, Bin Duan, Xiaohong Qin, Jonathan T Butcher
: Regeneration and repair of injured or diseased heart valves remains a clinical challenge. Tissue engineering provides a promising treatment approach to facilitate living heart valve repair and regeneration. Three-dimensional (3D) biomimetic scaffolds that possess heterogeneous and anisotropic features that approximate those of native heart valve tissue are beneficial to the successful in vitro development of tissue engineered heart valves (TEHV). Here we report the development and characterization of a novel composite scaffold consisting of nano- and micro-scale fibrous woven fabrics and 3D hydrogels by using textile techniques combined with bioactive hydrogel formation...
January 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28097935/finite-element-simulations-of-the-head-brain-responses-to-the-top-impacts-of-a-construction-helmet-effects-of-the-neck-and-body-mass
#16
John Z Wu, Christopher S Pan, Bryan M Wimer, Charles L Rosen
Traumatic brain injuries are among the most common severely disabling injuries in the United States. Construction helmets are considered essential personal protective equipment for reducing traumatic brain injury risks at work sites. In this study, we proposed a practical finite element modeling approach that would be suitable for engineers to optimize construction helmet design. The finite element model includes all essential anatomical structures of a human head (i.e. skin, scalp, skull, cerebrospinal fluid, brain, medulla, spinal cord, cervical vertebrae, and discs) and all major engineering components of a construction helmet (i...
January 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28089422/low-magnitude-mechanical-signals-and-the-spine-a-review-of-current-and-future-applications
#17
REVIEW
Martin H Pham, Zorica Buser, Jeffrey C Wang, Frank L Acosta
Animal and human studies demonstrate the anabolic properties of low-magnitude mechanical stimulation (LMMS) in its ability to improve bone formation by enhancing the proliferation of mesenchymal stem cells and their subsequent commitment down an osteoblastic lineage. Response to mechanical strains as low as 10μɛ have been seen, illustrating the sensitivity of mechanosensory cells to mechanotransduction pathways. Applications to the spine include treatment of osteoporosis in preparation for instrumented fusion, fracture reduction in spinal cord injury patients to slow bone mineral density loss, and bone tissue engineering and enhancement of bone-implant osseointegration for pseudarthrosis and hardware failure...
January 12, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28087486/enhanced-articular-cartilage-by-human-mesenchymal-stem-cells-in-enzymatically-mediated-transiently-rgds-functionalized-collagen-mimetic-hydrogels
#18
Paresh A Parmar, Jean-Philippe St-Pierre, Lesley W Chow, Christopher D Spicer, Violet Stoichevska, Yong Y Peng, Jerome A Werkmeister, John A M Ramshaw, Molly M Stevens
: Recapitulation of the articular cartilage microenvironment for regenerative medicine applications faces significant challenges due to the complex and dynamic biochemical and biomechanical nature of native tissue. Towards the goal of biomaterial designs that enable the temporal presentation of bioactive sequences, recombinant bacterial collagens such as Streptococcal collagen-like 2 (Scl2) proteins can be employed to incorporate multiple specific bioactive and biodegradable peptide motifs into a single construct...
January 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28077052/examinations-of-a-new-long-term-degradable-electrospun-polycaprolactone-scaffold-in-three-rat-abdominal-wall-models
#19
Hanna Jangö, Søren Gräs, Lise Christensen, Gunnar Lose
Alternative approaches to reinforce native tissue in reconstructive surgery for pelvic organ prolapse are warranted. Tissue engineering combines the use of a scaffold with the regenerative potential of stem cells and is a promising new concept in urogynecology. Our objective was to evaluate whether a newly developed long-term degradable polycaprolactone scaffold could provide biomechanical reinforcement and function as a scaffold for autologous muscle fiber fragments. We performed a study with three different rat abdominal wall models where the scaffold with or without muscle fiber fragments was placed (1) subcutaneously (minimal load), (2) in a partial defect (partial load), and (3) in a full-thickness defect (heavy load)...
February 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28072567/commentary-on-the-integration-of-model-sharing-and-reproducibility-analysis-to-scholarly-publishing-workflow-in-computational-biomechanics
#20
Ahmet Erdemir, Trent M Guess, Jason P Halloran, Luca Modenese, Jeffrey A Reinbolt, Darryl G Thelen, Brian R Umberger, Ahmet Erdemir, Trent M Guess, Jason P Halloran, Luca Modenese, Jeffrey A Reinbolt, Darryl G Thelen, Brian R Umberger, Brian R Umberger, Ahmet Erdemir, Darryl G Thelen, Trent M Guess, Jeffrey A Reinbolt, Luca Modenese, Jason P Halloran
OBJECTIVE: The overall goal of this paper is to demonstrate that dissemination of models and analyses for assessing the reproducibility of simulation results can be incorporated in the scientific review process in biomechanics. METHODS: As part of a special issue on model sharing and reproducibility in the IEEE Transactions on Biomedical Engineering, two manuscripts on computational biomechanics were submitted: Rajagopal et al., IEEE Trans. Biomed. Eng., 2016 and Schmitz and Piovesan, IEEE Trans...
October 2016: IEEE Transactions on Bio-medical Engineering
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