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Biomechanical engineering

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https://www.readbyqxmd.com/read/29777504/implementation-and-validation-of-constitutive-relations-for-human-dermis-mechanical-response
#1
Alessandra Aldieri, Mara Terzini, Cristina Bignardi, Elisabetta M Zanetti, Alberto L Audenino
Finite element models in conjunction with adequate constitutive relations are pivotal in several physiological and medical applications related to both native and engineered tissues, allowing to predict the tissue response under various loading states. In order to get reliable results, however, the validation of the constitutive models is crucial. Therefore, the main purpose of this work is to provide an experimental-computational approach to the biomechanical investigation of soft tissues such as the dermis...
May 19, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29773424/a-device-for-high-throughput-monitoring-of-degradation-in-soft-tissue-samples
#2
D S Tzeranis, I Panagiotopoulos, S Gkouma, G Kanakaris, N Georgiou, N Vaindirlis, G Vasileiou, M Neidlin, A Gkousioudi, V Spitas, G A Macheras, L G Alexopoulos
This work describes the design and validation of a novel device, the High-Throughput Degradation Monitoring Device (HDD), for monitoring the degradation of 24 soft tissue samples over incubation periods of several days inside a cell culture incubator. The device quantifies sample degradation by monitoring its deformation induced by a static gravity load. Initial instrument design and experimental protocol development focused on quantifying cartilage degeneration. Characterization of measurement errors, caused mainly by thermal transients and by translating the instrument sensor, demonstrated that HDD can quantify sample degradation with <6 μm precision and <10 μm temperature-induced errors...
May 3, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29751516/engineering-a-3d-bioprinted-model-of-human-heart-valve-disease-using-nanoindentation-based-biomechanics
#3
Dewy C van der Valk, Casper F T van der Ven, Mark C Blaser, Joshua M Grolman, Pin-Jou Wu, Owen S Fenton, Lang H Lee, Mark W Tibbitt, Jason L Andresen, Jennifer R Wen, Anna H Ha, Fabrizio Buffolo, Alain van Mil, Carlijn V C Bouten, Simon C Body, David J Mooney, Joost P G Sluijter, Masanori Aikawa, Jesper Hjortnaes, Robert Langer, Elena Aikawa
In calcific aortic valve disease (CAVD), microcalcifications originating from nanoscale calcifying vesicles disrupt the aortic valve (AV) leaflets, which consist of three (biomechanically) distinct layers: the fibrosa, spongiosa, and ventricularis. CAVD has no pharmacotherapy and lacks in vitro models as a result of complex valvular biomechanical features surrounding resident mechanosensitive valvular interstitial cells (VICs). We measured layer-specific mechanical properties of the human AV and engineered a three-dimensional (3D)-bioprinted CAVD model that recapitulates leaflet layer biomechanics for the first time...
May 3, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29749108/biomaterial-characterization-of-off-the-shelf-decellularized-porcine-pericardial-tissue-for-use-in-prosthetic-valvular-applications
#4
Joshua A Choe, Soumen Jana, Brandon J Tefft, Ryan S Hennessy, Jason Go, David Morse, Amir Lerman, Melissa D Young
Fixed pericardial tissue is commonly used for commercially available xenograft valve implants, and has proven durability, but lacks the capability to remodel and grow. Decellularized porcine pericardial tissue has the promise to outperform fixed tissue and remodel, but the decellularization process has been shown to damage the collagen structure and reduce mechanical integrity of the tissue. Therefore, a comparison of uniaxial tensile properties was performed on decellularized, decellularized-sterilized, fixed, and native porcine pericardial tissue, versus native valve leaflet cusps...
May 10, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29746144/effects-of-allogenic-dermal-fibroblasts-on-rotator-cuff-healing-in-a-rabbit-model-of-chronic-tear
#5
Jieun Kwon, Yun Hee Kim, Sung-Min Rhee, Tae In Kim, Jimin Lee, Saewha Jeon, Joo Han Oh
BACKGROUND: The failure of rotator cuffs to heal after repair is an unresolved surgical issue. There have been substantial efforts, including the use of biological supplements, to enhance tendon healing. Dermal fibroblasts are a good candidate for tendon tissue engineering because they are similar to the tenocytes used for collagen synthesis. In addition, they are easily accessible because autologous dermal fibroblasts can be obtained from individual skin without major skin defects and allogenic dermal fibroblasts (ADFs) have already been commercialized in the field of skin engineering...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29742511/decellularized-pancreas-matrix-scaffolds-for-tissue-engineering-using-ductal-or-arterial-catheterization
#6
Javad Hashemi, Parvin Pasalar, Masoud Soleimani, Ehsan Arefian, Reza Khorramirouz, Aram Akbarzadeh, Fariba Ghorbani, Seyed Ehsan Enderami, Abdol Mohammad Kajbafzadeh
INTRODUCTION: Diabetes is known as a worldwide disease with a great burden on society. Since therapeutic options cover a limited number of target points, new therapeutic strategies in the field of regenerative medicine are considered. Bioscaffolds along with islet cells would provide bioengineered tissue as a substitute for β-cells. The perfusion-decellularization technique is considered to create such scaffolds since they mimic the compositional, architectural, and biomechanical nature of a native organ...
May 9, 2018: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/29740580/engineering-scalable-manufacturing-of-high-quality-stem-cell-derived-cardiomyocytes-for-cardiac-tissue-repair
#7
REVIEW
Kaitlin K Dunn, Sean P Palecek
Recent advances in the differentiation and production of human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) have stimulated development of strategies to use these cells in human cardiac regenerative therapies. A prerequisite for clinical trials and translational implementation of hPSC-derived CMs is the ability to manufacture safe and potent cells on the scale needed to replace cells lost during heart disease. Current differentiation protocols generate fetal-like CMs that exhibit proarrhythmogenic potential...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29737330/therapy-for-cartilage-defects-functional-ectopic-cartilage-constructed-by-cartilage-simulating-collagen-chondroitin-sulfate-and-hyaluronic-acid-cch-hybrid-hydrogel-with-allogeneic-chondrocytes
#8
Xianfang Jiang, Junting Liu, Qin Liu, Zhenhui Lu, Li Zheng, Jinmin Zhao, Xingdong Zhang
OBJECTIVE: To regenerate functional cartilage-mimicking ectopic cartilage as a source for the restoration of cartilage defects, we used a previously synthesized three-phase collagen, chondroitin sulfate and hyaluronic acid (CCH) hydrogel for the encapsulation of allogeneic chondrocytes with a diffusion chamber system that was buried subcutaneously in the host for 4 weeks and then implanted into a cartilage defect. METHODS: The CCH hydrogel was prepared and seeded with allogeneic chondrocytes from new-born rabbits, prior to being enveloped in a diffusion chamber that prevents cell ingrowth and vascular invasion of the host, as described previously...
May 8, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29737043/bioreactors-for-cardiac-tissue-engineering
#9
REVIEW
Jesus Paez-Mayorga, Gustavo Hernández-Vargas, Guillermo U Ruiz-Esparza, Hafiz M N Iqbal, Xichi Wang, Yu Shrike Zhang, Roberto Parra-Saldivar, Ali Khademhosseini
The advances in biotechnology, biomechanics, and biomaterials can be used to develop organ models that aim to accurately emulate their natural counterparts. Heart disease, one of the leading causes of death in modern society, has attracted particular attention in the field of tissue engineering. To avoid incorrect prognosis of patients suffering from heart disease, or from adverse consequences of classical therapeutic approaches, as well as to address the shortage of heart donors, new solutions are urgently needed...
May 8, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29736579/combination-of-polymeric-supports-and-drug-delivery-systems-for-osteochondral-regeneration
#10
Luis Rojo
Musculoskeletal conditions have been defined by European National Health systems as one of the key themes which should be featured during the present decade as a consequence of the significant healthcare and social support costs. Among others, articular cartilage degeneration due to traumatic and degenerative lesion injury or other pathologies commonly results in the development of musculoskeletal disorders such as osteoarthritis and arthritis rheumatoid, eventually leading to progressive articular cartilage and joint destruction especially at osteochondral interphase, that account for more disability among the elderly than any other diseases constituting a global social challenge that needs a multidisciplinary response from the scientific community...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29736578/enhancing-biological-and-biomechanical-fixation-of-osteochondral-scaffold-a-grand-challenge
#11
Maryam Tamaddon, Chaozong Liu
Osteoarthritis (OA) is a degenerative joint disease, typified by degradation of cartilage and changes in the subchondral bone, resulting in pain, stiffness and reduced mobility. Current surgical treatments often fail to regenerate hyaline cartilage and result in the formation of fibrocartilage. Tissue engineering approaches have emerged for the repair of cartilage defects and damages to the subchondral bones in the early stage of OA and have shown potential in restoring the joint's function. In this approach, the use of three-dimensional scaffolds (with or without cells) provides support for tissue growth...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29736568/emerging-concepts-in-treating-cartilage-osteochondral-defects-and-osteoarthritis-of-the-knee-and-ankle
#12
Hélder Pereira, Ibrahim Fatih Cengiz, Carlos Vilela, Pedro L Ripoll, João Espregueira-Mendes, J Miguel Oliveira, Rui L Reis, C Niek van Dijk
The management and treatment of cartilage lesions, osteochondral defects, and osteoarthritis remain a challenge in orthopedics. Moreover, these entities have different behaviors in different joints, such as the knee and the ankle, which have inherent differences in function, biology, and biomechanics. There has been a huge development on the conservative treatment (new technologies including orthobiologics) as well as on the surgical approach. Some surgical development upraises from technical improvements including advanced arthroscopic techniques but also from increased knowledge arriving from basic science research and tissue engineering and regenerative medicine approaches...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29731951/advanced-computational-methods-in-bio-mechanics
#13
REVIEW
Waleed M S Al Qahtani, Mohamed I El-Anwar
A novel partnership between surgeons and machines, made possible by advances in computing and engineering technology, could overcome many of the limitations of traditional surgery. By extending surgeons' ability to plan and carry out surgical interventions more accurately and with fewer traumas, computer-integrated surgery (CIS) systems could help to improve clinical outcomes and the efficiency of healthcare delivery. CIS systems could have a similar impact on surgery to that long since realised in computer-integrated manufacturing...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29725971/a-comprehensive-review-of-stem-cells-for-cartilage-regeneration-in-osteoarthritis
#14
Gauthaman Kalamegam, Adnan Memic, Emma Budd, Mohammed Abbas, Ali Mobasheri
Osteoarthritis (OA) is an age related joint disease associated with degeneration and loss of articular cartilage. Consequently, OA patients suffer from chronic joint pain and disability. Weight bearing joints and joints that undergo repetitive stress and excessive 'wear and tear' are particularly prone to developing OA. Cartilage has a poor regenerative capacity and current pharmacological agents only provide symptomatic pain relief. OA patients that respond poorly to conventional therapies are ultimately treated with surgical procedures to promote cartilage repair by implantation of artificial joint structures (arthroplasty) or total joint replacement (TJR)...
May 4, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29701908/advances-in-osteobiologic-materials-for-bone-substitutes
#15
REVIEW
Anwarul Hasan, Batzaya Byambaa, Mahboob Morshed, Mohammad Ibrahim Cheikh, Rana Abdul Shakoor, Tanvir Mustafy, Hany Marei
A significant challenge in the current orthopedics is the development of suitable osteobiologic materials that can replace the conventional allografts, autografts and xenografts, and thereby serve as implant materials as bone substitutes for bone repair or remodeling. The complex biology behind the nano-microstructure of bones and their repair mechanisms, which involve various types of chemical and biomechanical signaling amongst different cells, has set strong requirements for biomaterials to be used in bone tissue engineering...
April 27, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29687381/decellularized-adipose-tissue-scaffolds-for-soft-tissue-regeneration-and-adipose-derived-stem-stromal-cell-delivery
#16
Pascal Morissette Martin, Arthi Shridhar, Claire Yu, Cody Brown, Lauren E Flynn
Surgically discarded adipose tissue is not only an abundant source of multipotent adipose-derived stem/stromal cells (ASCs) but can also be decellularized to obtain a biomimetic microenvironment for tissue engineering applications. The decellularization methods involve processing excised fat through a series of chemical, mechanical, and enzymatic treatment stages designed to extract cells, cellular components, and lipid from the tissues. This process yields a complex 3D bioscaffold enriched in collagens that mimics the biochemical and biomechanical properties of the native extracellular matrix (ECM)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29685821/3d-printed-scaffolds-with-calcified-layer-for-osteochondral-tissue-engineering
#17
Zhengyu Li, Shuaijun Jia, Zhuo Xiong, Qianfa Long, Shaorong Yan, Fu Hao, Jian Liu, Zhi Yuan
Treating full-layer injury of bone and cartilage is currently a significant challenge in orthopedic trauma repair. Joint damage typically includes chondral defects, and the underlying subchondral defect sites are difficult to repair. Tissue engineering technology could potentially be used to treat such injuries; however, results to date been unsatisfactory. The aim of this study was to design a multilayer composite scaffold containing cartilage, bone, and calcified layers to simulate physiological full-thickness bone-cartilage structure...
April 21, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29675269/translation-of-remote-control-regenerative-technologies-for-bone-repair
#18
Hareklea Markides, Jane S McLaren, Neil D Telling, Noura Alom, E'atelaf A Al-Mutheffer, Richard O C Oreffo, Andrew Zannettino, Brigitte E Scammell, Lisa J White, Alicia J El Haj
The role of biomechanical stimuli, or mechanotransduction, in normal bone homeostasis and repair is understood to facilitate effective osteogenesis of mesenchymal stem cells (MSCs) in vitro. Mechanotransduction has been integrated into a multitude of in vitro bone tissue engineering strategies and provides an effective means of controlling cell behaviour towards therapeutic outcomes. However, the delivery of mechanical stimuli to exogenous MSC populations, post implantation, poses a significant translational hurdle...
2018: NPJ Regenerative Medicine
https://www.readbyqxmd.com/read/29667640/-the-efficiency-of-the-application-of-the-modern-computed-technologies-in-the-clinical-practice-and-the-prospects-for-the-further-use-of-the-biomechanical-3d-models-in-forensic-medicine
#19
I Yu Makarov, A V Svetlakov, A V Sotin, S V Shigeev, A A Gusarov, S A Smirenin, V V Emelin, V B Stragis, V A Fetisov
To-day, the computer-assisted 3D-technologies for the mathematical simulation of the engineering facilities are extensively used for the purpose of technical calculations in all branches of industry and building. The positive experience gained with the application of the 3D-models finds wide application in the joined investigations on the topical problems of the prosthetic and surgical treatment of bones, teeth, joints, cardiac valves, blood vessels, etc. The objective of the present study was the analysis of the positive experience with the involvement of the specialists in the design and practical application of 3D-models for the solution of problems facing the medical prosthetics and the management of various pathological conditions...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29666653/mesenchymal-stem-cells-in-oriented-plga-acecm-composite-scaffolds-enhance-structure-specific-regeneration-of-hyaline-cartilage-in-a-rabbit-model
#20
Weimin Guo, Xifu Zheng, Weiguo Zhang, Mingxue Chen, Zhenyong Wang, Chunxiang Hao, Jingxiang Huang, Zhiguo Yuan, Yu Zhang, Mingjie Wang, Jiang Peng, Aiyuan Wang, Yu Wang, Xiang Sui, Wenjing Xu, Shuyun Liu, Shibi Lu, Quanyi Guo
Articular cartilage lacks a blood supply and nerves. Hence, articular cartilage regeneration remains a major challenge in orthopedics. Decellularized extracellular matrix- (ECM-) based strategies have recently received particular attention. The structure of native cartilage exhibits complex zonal heterogeneity. Specifically, the development of a tissue-engineered scaffold mimicking the aligned structure of native cartilage would be of great utility in terms of cartilage regeneration. Previously, we fabricated oriented PLGA/ACECM (natural, nanofibrous, articular cartilage ECM) composite scaffolds...
2018: Stem Cells International
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