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https://www.readbyqxmd.com/read/27816476/sex-specific-modulation-of-the-gut-microbiome-and-behavior-in-siberian-hamsters
#1
Kristyn E Sylvia, Cathleen P Jewell, Nikki M Rendon, Emma A St John, Gregory E Demas
The gut microbiome is a diverse, host-specific, and symbiotic bacterial environment that is critical for mammalian survival and exerts a surprising yet powerful influence on brain and behavior. Gut dysbiosis has been linked to a wide range of physical and psychological disorders, including autism spectrum disorders and anxiety, as well as autoimmune and inflammatory disorders. A wealth of information on the effects of dysbiosis on anxiety and depression has been reported in laboratory model systems (e.g., germ-free mice); however, the effects of microbiome disruption on social behaviors (e...
November 2, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27240605/practices-and-outcomes-of-self-treatment-with-helminths-based-on-physicians-observations
#2
J Liu, R A Morey, J K Wilson, W Parker
The successful use of helminths as therapeutic agents to resolve inflammatory disease was first recorded 40 years ago. Subsequent work in animal models and in humans has demonstrated that the organisms might effectively treat a wide range of inflammatory diseases, including allergies, autoimmune disorders and inflammation-associated neuropsychiatric disorders. However, available information regarding the therapeutic uses and effects of helminths in humans is limited. This study probes the practices and experiences of individuals 'self-treating' with helminths through the eyes of their physicians...
May 31, 2016: Journal of Helminthology
https://www.readbyqxmd.com/read/24997041/microbiota-immunoregulatory-old-friends-and-psychiatric-disorders
#3
REVIEW
Graham A W Rook, Charles L Raison, Christopher A Lowry
Regulation of the immune system is an important function of the gut microbiota. Increasing evidence suggests that modern living conditions cause the gut microbiota to deviate from the form it took during human evolution. Contributing factors include loss of helminth infections, encountering less microbial biodiversity, and modulation of the microbiota composition by diet and antibiotic use. Thus the gut microbiota is a major mediator of the hygiene hypothesis (or as we prefer, "Old Friends" mechanism), which describes the role of organisms with which we co-evolved, and that needed to be tolerated, as crucial inducers of immunoregulation...
2014: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/24370461/the-role-of-microbiome-in-central-nervous-system-disorders
#4
REVIEW
Yan Wang, Lloyd H Kasper
Mammals live in a co-evolutionary association with the plethora of microorganisms that reside at a variety of tissue microenvironments. The microbiome represents the collective genomes of these co-existing microorganisms, which is shaped by host factors such as genetics and nutrients but in turn is able to influence host biology in health and disease. Niche-specific microbiome, prominently the gut microbiome, has the capacity to effect both local and distal sites within the host. The gut microbiome has played a crucial role in the bidirectional gut-brain axis that integrates the gut and central nervous system (CNS) activities, and thus the concept of microbiome-gut-brain axis is emerging...
May 2014: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/15070545/the-broad-autism-phenotype-findings-from-an-epidemiological-survey
#5
N Micali, S Chakrabarti, E Fombonne
This study aimed to determine if relatives of children with autism and less severe pervasive developmental disorders (PDDs) have higher rates of various components of the broad autistic phenotype. Psychiatric and medical disorders were investigated. Parents of children with PDDs were selected from an epidemiological survey and compared with parents of control children with non-autistic developmental problems. Rates of abnormalities and disorders were compared in relatives of 79 cases and 61 controls. Medical and autoimmune disorders in both groups were endorsed by few relatives...
March 2004: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/11863398/the-central-role-of-magnesium-deficiency-in-tourette-s-syndrome-causal-relationships-between-magnesium-deficiency-altered-biochemical-pathways-and-symptoms-relating-to-tourette-s-syndrome-and-several-reported-comorbid-conditions
#6
B L Grimaldi
Prior studies have suggested a common etiology involved in Tourette's syndrome and several comorbid conditions and symptomatology. Reportedly, current medications used in Tourette's syndrome have intolerable side-effects or are ineffective for many patients. After thoroughly researching the literature, I hypothesize that magnesium deficiency may be the central precipitating event and common pathway for the subsequent biochemical effects on substance P, kynurenine, NMDA receptors, and vitamin B6 that may result in the symptomatology of Tourette's syndrome and several reported comorbid conditions...
January 2002: Medical Hypotheses
https://www.readbyqxmd.com/read/6146917/how-information-processing-mode-could-affect-prostaglandin-e1-metabolism-and-lung-inactivation-relevance-of-hemispheric-specialization-neurotransmitter-asymmetry-and-brain-reactivity
#7
COMPARATIVE STUDY
J Backon
Due to asymmetry of brain neurotransmitters and differential hemispheric information processing modes, it is suggested that the excessive use of one information processing mode could engender a state of brain reactivity whose neurochemical correlates would be either a rise in melatonin or beta-endorphin in systemic circulation. Since melatonin and beta-endorphin have opposite effects on lung-mediated regulation of prostaglandins, it is further suggested that the pulmonary inactivation of prostaglandin E1 would either be increased or inhibited...
June 1984: Medical Hypotheses
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