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APPL1

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https://www.readbyqxmd.com/read/28472298/adiponectin-stimulates-lipid-metabolism-via-ampk-in-rabbit-blastocysts
#1
Maria Schindler, Mareike Pendzialek, Katarzyna Joanna Grybel, Tom Seeling, Jacqueline Gürke, Bernd Fischer, Anne Navarrete Santos
STUDY QUESTION: How does a maternal diabetic hyperadiponectineamia affect signal transduction and lipid metabolism in rabbit preimplantation blastocysts? SUMMARY ANSWER: In a diabetic pregnancy increased levels of adiponectin led to a switch in embryonic metabolism towards a fatty acid-dependent energy metabolism, mainly affecting genes that are responsible for fatty acid uptake and turnover. WHAT IS KNOWN ALREADY: Although studies in cell culture experiments have shown that adiponectin is able to regulate lipid metabolism via 5'-AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor α (PPARα), data on the effects of adiponectin on embryonic lipid metabolism are not available...
May 4, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28415720/the-function-of-oxytocin-a-potential-biomarker-for-prostate-cancer-diagnosis-and-promoter-of-prostate-cancer
#2
Huan Xu, Shi Fu, Qi Chen, Meng Gu, Juan Zhou, Chong Liu, Yanbo Chen, Zhong Wang
PURPOSE: To measure the level of oxytocin in serum and prostate cancer (PCa) tissue and study its effect on the proliferation of PCa cells. RESULTS: Oxytocin level in serum was significantly increased in PCa patients compared with the no-carcinoma individuals. Additionally, the levels of oxytocin and its receptor were also elevated in the PCa tissue. However, no significant difference existed among the PCa of various Gleason grades. Western blot analysis confirmed the previous results and revealed an increased expression level of APPL1...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28176455/adiponectin-promotes-human-jaw-bone-marrow-mesenchymal-stem-cell-chemotaxis-via-cxcl1-and-cxcl8
#3
Yinfei Pu, Mengke Wang, Yingying Hong, Yuwei Wu, Zhihui Tang
Adiponectin (APN) is known to promote the osteogenic differentiation of human jaw bone marrow mesenchymal stem cells (h-JBMMSCs). However, the underlying mechanism has not been fully elucidated. Previously, we showed that APN could promote h-JBMMSC osteogenesis via APPL1-p38 by up-regulating osteogenesis-related genes. Here, we aimed to determine whether APN could promote h-JBMMSC chemotaxis through CXCL1/CXCL8. The CCK-8, wound healing and transwell assays were used to evaluate the proliferation, migration and chemotaxis of h-JBMMSCs with or without APN treatment...
February 8, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28143933/filopodia-formation-and-endosome-clustering-induced-by-mutant-plus-end-directed-myosin-vi
#4
Thomas A Masters, Folma Buss
Myosin VI (MYO6) is the only myosin known to move toward the minus end of actin filaments. It has roles in numerous cellular processes, including maintenance of stereocilia structure, endocytosis, and autophagosome maturation. However, the functional necessity of minus-end-directed movement along actin is unclear as the underlying architecture of the local actin network is often unknown. To address this question, we engineered a mutant of MYO6, MYO6+, which undergoes plus-end-directed movement while retaining physiological cargo interactions in the tail...
February 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28108259/appls-more-than-just-adiponectin-receptor-binding-proteins
#5
REVIEW
Zhuoying Liu, Ting Xiao, Xiaoyu Peng, Guangdi Li, Fang Hu
APPLs (adaptor proteins containing the pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif) are multifunctional adaptor proteins that bind to various membrane receptors, nuclear factors and signaling proteins to regulate many biological activities and processes, such as cell proliferation, chromatin remodeling, endosomal trafficking, cell survival, cell metabolism and apoptosis. APPL1, one of the APPL isoforms, was the first identified protein and interacts directly with adiponectin receptors to mediate adiponectin signaling to enhance lipid oxidation and glucose uptake...
January 17, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28011992/appl1-prevents-pancreatic-beta-cell-death-and-inflammation-by-dampening-nf%C3%AE%C2%BAb-activation-in-a-mouse-model-of-type-1-diabetes
#6
Xue Jiang, Yawen Zhou, Kelvin K L Wu, Zhanrui Chen, Aimin Xu, Kenneth K Y Cheng
AIMS/HYPOTHESIS: Beta cell inflammation and demise is a feature of type 1 diabetes. The insulin-sensitising molecule 'adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1' (APPL1), which contains an NH2-terminal Bin/Amphiphysin/Rvs domain, a central pleckstrin homology domain and a COOH-terminal phosphotyrosine-binding domain, has been shown to modulate inflammatory response in various cell types but its role in regulating beta cell mass and inflammation in type 1 diabetes remains unknown...
March 2017: Diabetologia
https://www.readbyqxmd.com/read/27916608/functional-properties-of-hepatocytes-in-vitro-are-correlated-with-cell-polarity-maintenance
#7
Anja Zeigerer, Anne Wuttke, Giovanni Marsico, Sarah Seifert, Yannis Kalaidzidis, Marino Zerial
Exploring the cell biology of hepatocytes in vitro could be a powerful strategy to dissect the molecular mechanisms underlying the structure and function of the liver in vivo. However, this approach relies on appropriate in vitro cell culture systems that can recapitulate the cell biological and metabolic features of the hepatocytes in the liver whilst being accessible to experimental manipulations. Here, we adapted protocols for high-resolution fluorescence microscopy and quantitative image analysis to compare two primary hepatocyte culture systems, monolayer and collagen sandwich, with respect to the distribution of two distinct populations of early endosomes (APPL1 and EEA1-positive), endocytic capacity, metabolic and signaling activities...
January 1, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/27820851/appl1-mediating-leptin-signaling-contributes-to-proliferation-and-migration-of-cancer-cells
#8
Youming Ding, Yingkang Cao, Bin Wang, Lei Wang, Yemin Zhang, Deling Zhang, Xiaoyan Chen, Mingxin Li, Changhua Wang
Leptin has been implicated in tumorigenesis and tumor progression, particularly in obese patients. As a multifunctional adaptor protein, APPL1 (containing pleckstrin homology domain, phosphotyrosine binding domain, and a leucine zipper motif 1) plays a critical role in regulating adiponectin and insulin signaling pathways. Currently, high APPL1 level has been suggested to be related to metastases and progression of some types of cancer. However, the intercourse between leptin signaling pathway and APPL1 remains poorly understood...
2016: PloS One
https://www.readbyqxmd.com/read/27771154/incretin-treatment-and-atherosclerotic-plaque-stability-role-of-adiponectin-appl1-signaling-pathway
#9
Michelangela Barbieri, Raffaele Marfella, Antonietta Esposito, Maria Rosaria Rizzo, Edith Angellotti, Ciro Mauro, Mario Siniscalchi, Fabio Chirico, Pasquale Caiazzo, Fulvio Furbatto, Alessandro Bellis, Nunzia D'Onofrio, Milena Vitiello, Franca Ferraraccio, Giuseppe Paolisso, Maria Luisa Balestrieri
AIMS: Glucagon like peptide 1 (GLP-1) analogues and dipeptidyl peptidase IV (DPP-4) inhibitors reduce atherosclerosis progression in type 2 diabetes mellitus (T2DM) patients and are associated with morphological and compositional characteristics of stable plaque phenotype. GLP-1 promotes the secretion of adiponectin which exerts anti-inflammatory effects through the adaptor protein PH domain and leucine zipper containing 1 (APPL1). The potential role of APPL1 expression in the evolution of atherosclerotic plaque in TDM2 patients has not previously evaluated...
October 5, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27763641/pkn2-and-cdo-interact-to-activate-akt-and-promote-myoblast-differentiation
#10
Sang-Jin Lee, Jeongmi Hwang, Hyeon-Ju Jeong, Miran Yoo, Ga-Yeon Go, Jae-Rin Lee, Young-Eun Leem, Jong Woo Park, Dong-Wan Seo, Yong Kee Kim, Myong-Joon Hahn, Jeung-Whan Han, Jong-Sun Kang, Gyu-Un Bae
Skeletal myogenesis is coordinated by multiple signaling pathways that control cell adhesion/migration, survival and differentiation accompanied by muscle-specific gene expression. A cell surface protein Cdo is involved in cell contact-mediated promyogenic signals through activation of p38MAPK and AKT. Protein kinase C-related kinase 2 (PKN2/PRK2) is implicated in regulation of various biological processes, including cell migration, adhesion and death. It has been shown to interact with and inhibit AKT thereby inducing cell death...
October 20, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27659231/erratum-appl1-counteracts-obesity-induced-vascular-insulin-resistance-and-endothelial-dysfunction-by-modulating-the-endothelial-production-of-nitric-oxide-and-endothelin-1-in-mice-diabetes-2011-60-3044-3054
#11
Yi Wang, Kenneth K Y Cheng, Karen S L Lam, Donghai Wu, Yu Wang, Yu Huang, Paul M Vanhoutte, Gary Sweeney, Yiming Li, Aimin Xu
No abstract text is available yet for this article.
October 2016: Diabetes
https://www.readbyqxmd.com/read/27659229/erratum-adiponectin-induced-endothelial-nitric-oxide-synthase-activation-and-nitric-oxide-production-are-mediated-by-appl1-in-endothelial-cells-diabetes-2007-56-1387-1394
#12
Kenneth K Y Cheng, Karen S L Lam, Yu Wang, Yu Huang, David Carling, Donghai Wu, Chiwai Wong, Aimin Xu
No abstract text is available yet for this article.
October 2016: Diabetes
https://www.readbyqxmd.com/read/27632382/effects-of-training-and-detraining-on-adiponectin-plasma-concentration-and-muscle-sensitivity-in-lean-and-overweight-men
#13
Caroline Gastebois, Clément Villars, Jocelyne Drai, Emmanuelle Canet-Soulas, Stéphane Blanc, Audrey Bergouignan, Etienne Lefai, Chantal Simon
PURPOSE: To delineate the direct effect of physical activity on adiponectin metabolism, we investigated the impact of contrasted physical activity changes, independent of body mass changes, on adiponectin plasma concentration and muscle sensitivity in lean and overweight adult males. METHODS: Eleven physically active lean men (70.6 ± 2.1 kg) were subjected to 1-month detraining; 9 sedentary lean men (73.1 ± 3.3 kg); and 11 sedentary overweight men (97.5 ± 3...
December 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27514712/altered-steroid-metabolism-and-insulin-signaling-in-pcos-endometria-impact-in-tissue-function
#14
Lorena Oróstica, Carlos Rosas, Francisca Plaza-Parrochia, Isis Astorga, Fernando Gabler, Víctor García, Carmen Romero, Margarita Vega
BACKGROUND: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine/ metabolic disorder characterized by hyperandrogenemia and in most cases, by hyperinsulinemia in addition to obesity. Besides ovarian dysfunction, endometrial physiology is also disrupted since this tissue is highly dependent on the action of steroids; in case of conception cycles, high percentage of abortion is observed. Because of the endocrine/metabolic alterations, PCOS-women present high probability to develop hyperplasia and endometrial cancer, where an imbalance of cell proliferation/apoptosis processes is detected...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27511117/experimental-verification-of-a-predicted-novel-microrna-located-in-human-pik3ca-gene-with-a-potential-oncogenic-function-in-colorectal-cancer
#15
Ali Jason Saleh, Bahram M Soltani, Sadat Dokanehiifard, Abdallah Medlej, Mahmoud Tavalaei, Seyed Javad Mowla
PI3K/AKT signaling is involved in cell survival, proliferation, and migration. In this pathway, PI3Kα enzyme is composed of a regulatory protein encoded by p85 gene and a catalytic protein encoded by PIK3CA gene. Human PIK3CA locus is amplified in several cancers including lung and colorectal cancer (CRC). Therefore, microRNAs (miRNAs) that are encoded within the PIK3CA gene might have a role in cancer development. Here, we report a novel microRNA named PIK3CA-miR1 (EBI accession no. LN626315), which is located within PIK3CA gene...
October 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27478065/appl1-promotes-glucose-uptake-in-response-to-mechanical-stretch-via-the-pkc%C3%AE-non-muscle-myosin-iia-pathway-in-c2c12-myotubes
#16
Tsugumichi Saito, Shuichi Okada, Yoko Shimoda, Yuko Tagaya, Aya Osaki, Eijiro Yamada, Ryo Shibusawa, Yasuyo Nakajima, Atsushi Ozawa, Tetsurou Satoh, Masatomo Mori, Masanobu Yamada
Expression of adaptor protein, phosphotyrosine interaction, pleckstrin homology domain, and leucine zipper containing 1 (APPL1) promoted glucose transporter 4 (GLUT4) translocation and glucose uptake in adipose and muscle tissues in response to stimulation with insulin, adiponectin, or exercise. In response to mechanical stretch, knockdown of APPL1 in C2C12 myotubes suppressed glucose uptake. APPL1-induced increased glucose uptake was mediated by protein kinase C (PKC) ζ but not AKT, AMPK, or calmodulin-dependent protein kinase...
November 2016: Cellular Signalling
https://www.readbyqxmd.com/read/27342590/erratum-to-evidence-for-decreased-expression-of-appl1-associated-with-reduced-insulin-and-adiponectin-receptors-expression-in-pcos-patients
#17
R Dehghan, M Saidijam, M Mehdizadeh, N Shabab, M Yavangi, T Artimani
No abstract text is available yet for this article.
June 24, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27300007/serine-707-of-appl1-is-critical-for-the-synaptic-nmda-receptor-mediated-akt-phosphorylation-signaling-pathway
#18
Jiejie Wang, Wen Lu, Lin Chen, Ping Zhang, Tingting Qian, Wei Cao, Jianhong Luo
Accumulating evidence indicates that the synaptic activation of N-methyl-D-aspartate receptors (NMDARs) has a neuroprotective effect on neurons. Our previous study demonstrated that APPL1 (adaptor protein containing pleckstrin homology domain, phosphotyrosine-binding domain, and leucine zipper motif) mediates the synaptic activity-dependent activation of PI3K-Akt signaling via coupling this pathway with NMDAR-PSD95 (postsynaptic density protein 95) complexes. However, the molecular mechanism underlying this process is still unknown...
August 2016: Neuroscience Bulletin
https://www.readbyqxmd.com/read/27257087/appl1-gates-long-term-potentiation-through-its-plekstrin-homology-domain
#19
Mónica Fernández-Monreal, Carla Sánchez-Castillo, José A Esteban
Hippocampal synaptic plasticity involves both membrane trafficking events and intracellular signaling, but how these are coordinated is far from clear. The endosomal transport of glutamate receptors in and out of the postsynaptic membrane responds to multiple signaling cascades triggered by synaptic activity. In this work, we have identified adaptor protein containing a plekstrin homology domain, phosphotyrosine-binding domain and leucine zipper motif 1 (APPL1) as a crucial element linking trafficking and signaling during synaptic plasticity...
July 15, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27246173/appl1-mediated-activation-of-stat3-contributes-to-inhibitory-effect-of-adiponectin-on-hepatic-gluconeogenesis
#20
Youming Ding, Deling Zhang, Bin Wang, Yemin Zhang, Lei Wang, Xiaoyan Chen, Mingxin Li, Zhao Tang, Changhua Wang
Adiponectin has been shown to suppress hepatic gluconeogenesis. However, the signaling pathways underlying its action remain ill-defined. The purpose of this study was to examine the potential role of APPL1 in mediating anti-gluconeogenic ability of adiponectin. Primary hepatocytes were isolated from male C57BL/6 mice. Western blot and RT-PCR were performed to detect protein expression and mRNA level, respectively. The protein-protein association was determined by immunoprecipitation and GST pull-down assay...
September 15, 2016: Molecular and Cellular Endocrinology
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