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https://www.readbyqxmd.com/read/16284791/the-role-of-nf-kappab-irf-1-and-stat-1alpha-transcription-factors-in-the-inos-gene-induction-by-gliadin-and-ifn-gamma-in-raw-264-7-macrophages
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Daniela De Stefano, Maria Chiara Maiuri, Barbara Iovine, Armando Ialenti, Maria Assunta Bevilacqua, Rosa Carnuccio
Nitric oxide (NO) plays an important role in the pathogenesis of celiac disease. We have examined the involvement of nuclear factor-kappaB (NF-kappaB), interferon regulatory factor-1 (IRF-1), and signal transducer and activator of transcription-1alpha (STAT-1alpha) on the synergistic induction of inducible nitric oxide synthase (iNOS) gene expression by gliadin (G) in association with interferon-gamma (IFN-gamma) in RAW 264.7 macrophages. We found that IFN-gamma was efficient in enhancing the basal transcription of the iNOS promoter at 1, 6, and 24 h, whereas G had no effect...
January 2006: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
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