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https://www.readbyqxmd.com/read/27911901/the-researchers-view-of-scientific-rigor-survey-on-the-conduct-and-reporting-of-in-vivo-research
#1
Thomas S Reichlin, Lucile Vogt, Hanno Würbel
Reproducibility in animal research is alarmingly low, and a lack of scientific rigor has been proposed as a major cause. Systematic reviews found low reporting rates of measures against risks of bias (e.g., randomization, blinding), and a correlation between low reporting rates and overstated treatment effects. Reporting rates of measures against bias are thus used as a proxy measure for scientific rigor, and reporting guidelines (e.g., ARRIVE) have become a major weapon in the fight against risks of bias in animal research...
2016: PloS One
https://www.readbyqxmd.com/read/27911466/transparent-nanofibrous-mesh-self-assembled-from-molecular-legos-for-high-efficiency-air-filtration-with-new-functionalities
#2
Varun Kumar Singh, Sai Kishore Ravi, Wanxin Sun, Swee Ching Tan
Alarming levels of particulate matter pollution in air pose a serious health threat in several countries, therefore intriguing a strong need for an economic and a viable technology of air filtration. Current air purification technology is rather expensive with certain types even having the risk of emitting hazardous by-products. The authors have developed a multifunctional air filter inspired from the nasal hairs possessing an ability to specifically trap/exhale the foreign particles and allergens while still letting the air flow...
December 2, 2016: Small
https://www.readbyqxmd.com/read/27910261/borderline-personality-disorder-features-emotion-dysregulation-and-non-suicidal-self-injury-preliminary-findings-in-a-sample-of-community-dwelling-italian-adolescents
#3
Antonella Somma, Carla Sharp, Serena Borroni, Andrea Fossati
In order to assess the relationships among borderline personality disorder features, non-suicidal self-injury (NSSI) and emotion dysregulation, 122 community-dwelling Italian adolescents were administered by the Italian translations of the Borderline Personality Features Scale for Children-11, the Deliberate Self-Harm Inventory and the Difficulties in Emotion Regulation Scale (DERS). Regression models showed that both Deliberate Self-Harm Inventory (DSHI) and DERS scores significantly predicted Borderline Personality Features Scale for Children-11 total score; moreover, the DSHI total score significantly predicted the DERS total score...
December 2, 2016: Personality and Mental Health
https://www.readbyqxmd.com/read/27909398/an-amyloid-like-pathological-conformation-of-tdp-43-is-stabilized-by-hypercooperative-hydrogen-bonds
#4
Miguel Mompeán, Marco Baralle, Emanuele Buratti, Douglas V Laurents
TDP-43 is an essential RNA-binding protein forming aggregates in almost all cases of sporadic amyotrophic lateral sclerosis (ALS) and many cases of frontotemporal lobar dementia (FTLD) and other neurodegenerative diseases. TDP-43 consists of a folded N-terminal domain with a singular structure, two RRM RNA-binding domains, and a long disordered C-terminal region which plays roles in functional RNA regulatory assemblies as well as pernicious aggregation. Evidence from pathological mutations and seeding experiments strongly suggest that TDP-43 aggregates are pathologically relevant through toxic gain-of-harmful-function and/or harmful loss-of-native-function mechanisms...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27908900/democratic-therapeutic-community-treatment-for-personality-disorder-randomised-controlled-trial
#5
Steve Pearce, Lisle Scott, Gillian Attwood, Kate Saunders, Madeleine Dean, Ritz De Ridder, David Galea, Haroula Konstantinidou, Mike Crawford
BACKGROUND: Democratic therapeutic community (DTC) treatment has been used for many years in an effort to help people with personality disorder. High-quality evidence from randomised controlled trials (RCTs) is absent. AIMS: To test whether DTC treatment reduces use of in-patient services and improves the mental health of people with personality disorder. METHOD: An RCT of 70 people meeting DSM-IV criteria for personality disorder (trial registration: ISRCTN57363317)...
December 1, 2016: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/27907898/obstetrical-and-perinatal-outcomes-following-blastocyst-transfer-compared-to-cleavage-transfer-a-systematic-review-and-meta-analysis
#6
W P Martins, C O Nastri, L Rienzi, S Z van der Poel, C R Gracia, C Racowsky
STUDY QUESTION: Is blastocyst transfer safe when compared to cleavage stage embryo transfer regarding obstetric and perinatal outcomes? SUMMARY ANSWER: The clinical equipoise between blastocyst and cleavage stage embryo transfer remains as the evidence associating blastocyst transfer with some adverse perinatal outcomes is of low/very low quality. WHAT IS KNOWN ALREADY: Extended embryo culture to the blastocyst stage provides some theoretical advantages and disadvantages...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27907073/how-do-allied-health-professionals-construe-the-role-of-the-remote-workforce-new-insight-into-their-recruitment-and-retention
#7
Narelle Campbell, Diann S Eley, Lindy McAllister
PURPOSE: Allied health workforce recruitment and retention in remote areas is a global problem. Using case studies from the Australian allied health workforce, this paper adds new information by combining personality trait information with a detailed understanding of how the cases construe the demands of remote work, which may be useful in addressing this problem. METHODS: Four cases (two urban, two remote) are presented from a mixed methods study (n = 562), which used (1) the Temperament and Character Inventory to investigate personality traits of allied health professionals; and (2) repertory grid interviews to reveal quantitatively and qualitatively how the cases construed their Ideal work role compared with their Current and a Remote role...
2016: PloS One
https://www.readbyqxmd.com/read/27903206/long-term-outcomes-after-severe-drug-overdose
#8
Lee Y Wong, Rinaldo Bellomo, Ray Robbins, Johan Martensson, Richard Kanaan, Richard Newton, Chih-Chiang Hu, David M Taylor
OBJECTIVE: The long-term outcomes of patients with drug overdose admitted to the intensive care unit compared with those admitted to general wards have not been assessed. We aimed to compare the recurrence of overdose, mortality after hospital discharge, cause of death and quality-of-life scores (using the EQ-5D questionnaire) between the ICU patients and general ward patients. METHODS: We performed a retrospective cohort study of 102 ICU patients with drug overdose and 102 matched general ward patients with drug overdose in a university-affiliated teaching hospital between 2009 and 2013...
December 2016: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/27903145/changes-in-coding-of-suicide-attempts-or-self-harm-with-transition-from-icd-9-to-icd-10
#9
Christine Stewart, Phillip M Crawford, Gregory E Simon
No abstract text is available yet for this article.
December 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27901211/how-to-tell-a-happy-from-an-unhappy-schizotype-personality-factors-and-mental-health-outcomes-in-individuals-with-psychotic-experiences
#10
Letícia O Alminhana, Miguel Farias, Gordon Claridge, Claude R Cloninger, Alexander Moreira-Almeida
Objective: It is unclear why some individuals reporting psychotic experiences have balanced lives while others go on to develop mental health problems. The objective of this study was to test if the personality traits of harm avoidance, self-directedness, and self-transcendence can be used as criteria to differentiate healthy from unhealthy schizotypal individuals. Methods: We interviewed 115 participants who reported a high frequency of psychotic experiences. The instruments used were the Temperament and Character Inventory (140), Structured Clinical Interview for DSM-IV, and the Oxford-Liverpool Inventory of Feelings and Experiences...
November 24, 2016: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27900393/the-effects-of-alcohol-related-harms-to-others-on-self-perceived-mental-well-being-in-a-canadian-sample
#11
Candace Lewis-Laietmark, Ashley Wettlaufer, Kevin D Shield, Norman Giesbrecht, Nicole April, Mark Asbridge, Colleen Dell, Jürgen Rehm, Tim Stockwell
OBJECTIVES: To examine (1) the harms related to the drinking of others in five Canadian provinces, stratified by socio-demographic variables, and (2) the relationship between these harms and mental well-being. METHODS: A telephone survey sampled 375 adults from British Columbia, Saskatchewan, Ontario, Quebec, and Nova Scotia. Harms related to the drinking of others were measured through 16 questions in the domains of psychological, physical, social, and financial harms...
November 29, 2016: International Journal of Public Health
https://www.readbyqxmd.com/read/27899216/poisoning-suicide-with-ingestion-of-the-pyrethroids-alpha-cypermethrin-and-deltamethrin-and-the-antidepressant-mirtazapine-a-case-report
#12
Vassiliki A Boumba, Georgios N Rallis, Theodore Vougiouklakis
This case report describes a death attributed to the intake of the pyrethroid insecticides, alpha-cypermethrin and deltamethrin, and the antidepressant mirtazapine. The autopsy findings showed absence of external traumatic injuries and internal generalized visceral congestion, edema and cyanosis. The toxicological results revealed the presence of a toxic concentration of mirtazapine (12.5mg/L and 10.7mg/L in blood and urine, respectively) and high concentrations of pyrethroids (2.46mg/L alpha-cypermethrin and 2...
November 22, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27897326/exploring-the-effectiveness-of-combined-mentalization-based-group-therapy-and-dialectical-behaviour-therapy-for-inpatients-with-borderline-personality-disorder-a-pilot-study
#13
Marc-Andreas Edel, Vanessa Raaff, Giancarlo Dimaggio, Anna Buchheim, Martin Brüne
OBJECTIVES: Borderline personality disorder (BPD) is characterized by emotional instability, interpersonal dysfunction, and other features that typically develop before a background of insecure attachment and traumatic experiences. Dialectical behaviour therapy (DBT) has proven highly effective in reducing self-harm and improving emotion regulation, whereby problems concerning social cognition, which are also characteristic of BPD, may need additional approaches such as mentalization-based treatment (MBT)...
November 29, 2016: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/27896539/why-health-and-social-care-support-for-people-with-long-term-conditions-should-be-oriented-towards-enabling-them-to-live-well
#14
Vikki A Entwistle, Alan Cribb, John Owens
There are various reasons why efforts to promote "support for self-management" have rarely delivered the kinds of sustainable improvements in healthcare experiences, health and wellbeing that policy leaders internationally have hoped for. This paper explains how the basis of failure is in some respects built into the ideas that underpin many of these efforts. When (the promotion of) support for self-management is narrowly oriented towards educating and motivating patients to adopt the behaviours recommended for disease control, it implicitly reflects and perpetuates limited and somewhat instrumental views of patients...
November 28, 2016: Health Care Analysis: HCA: Journal of Health Philosophy and Policy
https://www.readbyqxmd.com/read/27896133/genital-self-mutilation-case-in-high-level-educated-person
#15
Musab Ilgi, Cemil Kutsal, Elshad Abdullayev, Emre Aykanlı, Sinan Levent Kirecci
Self-mutilation is the deliberate direct injuring of body tissue, often done without suicidal intention. Genital self-mutilation is a very rare event and self-harm of the penis, especially in the genital system is exceedingly rare. Generally, this kind of behavior is related to psychotic disorders but can sometimes be seen in non-psychotic people due to bizarre autoerotic acts, a desire for to change sex or religious beliefs that view sexual intercourse as a sin. Our case was the reported genital self-mutilation as a result of the bizarre sexual arousal of a young man who is employed as an architect...
January 2017: Urology Case Reports
https://www.readbyqxmd.com/read/27892435/awareness-knowledge-and-practices-of-dental-waste-management-among-private-practitioners
#16
K N Abhishek, S Supreetha, N Varma Penumatsa, G Sam, S C Khanapure, S Sivarajan
Background Dental wastes are materials that have been utilized in dental clinics, which are no longer wanted for use and therefore discarded. Improper disposal of these dental wastes can cause harm to the dentist, the people in immediate vicinity of the dentist. Objective The present study was conducted to assess the knowledge and practices regarding Dental waste management among private practitioners. Method The study population included 186 private practitioners in three districts of Karnataka (Coorg, Mysore, Hassan), south India...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27891524/the-design-usability-and-feasibility-of-a-family-focused-diabetes-self-care-support-mhealth-intervention-for-diverse-low-income-adults-with-type-2-diabetes
#17
Lindsay Satterwhite Mayberry, Cynthia A Berg, Kryseana J Harper, Chandra Y Osborn
Family members' helpful and harmful actions affect adherence to self-care and glycemic control among adults with type 2 diabetes (T2D) and low socioeconomic status. Few family interventions for adults with T2D address harmful actions or use text messages to reach family members. Through user-centered design and iterative usability/feasibility testing, we developed a mHealth intervention for disadvantaged adults with T2D called FAMS. FAMS delivers phone coaching to set self-care goals and improve patient participant's (PP) ability to identify and address family actions that support/impede self-care...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27891139/regulation-of-phytosiderophore-release-and-antioxidant-defense-in-roots-driven-by-shoot-based-auxin-signaling-confers-tolerance-to-excess-iron-in-wheat
#18
Ahmad H Kabir, Most A Khatun, Mohammad M Hossain, Syed A Haider, Mohammad F Alam, Nishit K Paul
Iron (Fe) is essential but harmful for plants at toxic level. However, how wheat plants tolerate excess Fe remains vague. This study aims at elucidating the mechanisms underlying tolerance to excess Fe in wheat. Higher Fe concentration caused morpho-physiological retardation in BR 26 (sensitive) but not in BR 27 (tolerant). Phytosiderophore and 2-deoxymugineic acid showed no changes in BR 27 but significantly increased in BR 26 due to excess Fe. Further, expression of TaSAMS. TaDMAS1, and TaYSL15 significantly downregulated in BR 27 roots, while these were upregulated in BR 26 under excess Fe...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27890269/-anorexia-and-borderline-personality-disorder%C3%A2-bonds-pathology
#19
Delphine Cayn, Alexandra Pham-Scottez
Comorbidity with a borderline personality disorder is far from rare in patients suffering from eating disorders. Clinically, this presents as chronic instability in many areas: interpersonal relationships, self-image, emotions, mood and acting out. Treatment is mainly based on a containing and reassuring therapeutic framework. A care plan may be put in place that incorporates reducing impulsive harmful, eating and self-harming behaviours. Dialectical behaviour therapy is intended in particular to prevent suicide risk in borderline personality disorder patients...
November 2016: Soins. Psychiatrie
https://www.readbyqxmd.com/read/27889466/lower-cortisol-level-in-response-to-a-psychosocial-stressor-in-young-females-with-self-harm
#20
Paul L Plener, Katrin Zohsel, Erika Hohm, Arlette F Buchmann, T Banaschewski, Ulrich S Zimmermann, Manfred Laucht
BACKGROUND: Self-harm is highly prevalent in adolescence, often serving an emotion regulation function. Social stressors such as bullying are associated with self-harm. The neurobiological background of the relationship between social stressors and self-harm needs to be further understood to inform prevention and therapy. METHODS: Participants were members of an epidemiological cohort study. 130 female participants underwent the Trier Social Stress Test (TSST) at age 19...
November 14, 2016: Psychoneuroendocrinology
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