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Leishmania braziliensis

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https://www.readbyqxmd.com/read/28530056/-cutaneous-leishmaniasis-in-israel-2016-an-update
#1
REVIEW
Michal Solomon, Eli Schwartz
Leishmaniasis is endemic in Israel and is increasing in its frequency. The pathogens that cause cutaneous leishmaniasis (CL) in Israel are Leishmania major (L. major) and Leishmania tropica (L. tropica). In recent years, there have been significant changes in the distribution of these species. L. major is endemic mainly in the Negev, Arava and the Beit She'an Valley. L. tropica is endemic in Tiberias, northern Sea of Galilee, Samaria and in the vicinity of Jerusalem such as at Kfar Adumim, Ma'ale Adumim and Anathoth (north-east of Jerusalem)...
October 2016: Harefuah
https://www.readbyqxmd.com/read/28511704/the-use-of-kdna-minicircle-subclass-relative-abundance-to-differentiate-between-leishmania-l-infantum-and-leishmania-l-amazonensis
#2
Marcello Ceccarelli, Luca Galluzzi, Aurora Diotallevi, Francesca Andreoni, Hailie Fowler, Christine Petersen, Fabrizio Vitale, Mauro Magnani
BACKGROUND: Leishmaniasis is a neglected disease caused by many Leishmania species, belonging to subgenera Leishmania (Leishmania) and Leishmania (Viannia). Several qPCR-based molecular diagnostic approaches have been reported for detection and quantification of Leishmania species. Many of these approaches use the kinetoplast DNA (kDNA) minicircles as the target sequence. These assays had potential cross-species amplification, due to sequence similarity between Leishmania species. Previous works demonstrated discrimination between L...
May 16, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28502644/leishmania-v-braziliensis-infecting-bats-from-pantanal-wetland-brazil-first-records-for-platyrrhinus-lineatus-and-artibeus-planirostris
#3
Eduardo de Castro Ferreira, Agnes Antônio Sampaio Pereira, Maurício Silveira, Carina Margonari, Glaucia Elisete Barbosa Marcon, Adriana de Oliveira França, Ludiele Souza Castro, Marcelo Oscar Bordignon, Erich Fischer, Walfrido Moraes Tomas, Maria Elizabeth Cavalheiros Dorval, Célia Maria Ferreira Gontijo
In the New World genus Leishmania parasites are etiological agents of neglected zoonoses known as leishmaniasis. Its epidemiology is very complex due to the participation of several species of sand fly vectors and mammalian hosts, and man is an accidental host. Control is very difficult because of the different epidemiological patterns of transmission observed. Studies about Leishmania spp. infection in bats are so scarce, which represents a large gap in knowledge about the role of these animals in the transmission cycle of these pathogens, especially when considering that Chiroptera is one of the most abundant and diverse orders among mammals...
May 11, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28500815/oral-pentoxifylline-associated-with-pentavalent-antimony-a-randomized-trial-for-cutaneous-leishmaniasis
#4
Graça Brito, Mayra Dourado, Luiz Henrique Guimarães, Everson Meireles, Albert Schriefer, Edgar Marcelino de Carvalho, Paulo Roberto Lima Machado
AbstractCutaneous leishmaniasis (CL) by Leishmania braziliensis is associated with decreasing cure rates in Brazil. Standard treatment with pentavalent antimony (Sb(v)) cures only 50-60% of the cases. The immunopathogenesis of CL ulcer is associated with high interferon-γ and tumor necrosis factor (TNF) production. Pentoxifylline, a TNF inhibitor, has been successfully used in association with Sb(v) in mucosal and cutaneous leishmaniasis. This randomized, double-blind, and placebo-controlled trial aimed to evaluate the efficacy and safety of oral pentoxifylline plus Sb(v) versus placebo plus Sb(v) in patients with CL in Bahia, Brazil...
May 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28499458/evaluation-of-a-multilocus-sequence-typing-mlst-scheme-for-leishmania-viannia-braziliensis-and-leishmania-viannia-panamensis-in-colombia
#5
Giovanny Herrera, Carolina Hernández, Martha S Ayala, Carolina Flórez, Aníbal A Teherán, Juan David Ramírez
BACKGROUND: Leishmaniases are parasitic vector-borne diseases affecting more than 12 million people in 98 countries. In Colombia, leishmaniasis is widespread and the most common clinical manifestation is cutaneous, mainly caused by L. panamensis and L. braziliensis. Currently, the genetic diversity of these species in Colombia is unknown. To address this, we applied molecular techniques for their characterization, using multilocus sequence typing (MLST) to explore the genetic variability and phylodynamics of the disease...
May 12, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28482935/nerolidol-the-main-constituent-of-piper-aduncum-essential-oil-has-anti-leishmania-braziliensis-activity
#6
Ligia Fernanda Ceole, Maria DAS Graças Cardoso, Maurilio José Soares
Leishmania (Viannia) braziliensis is a protozoan that causes mucocutaneous leishmaniasis, which is an infectious disease that affects more than 12 million people worldwide. The available treatment is limited, has side-effects or is inefficient. In a search for alternative compounds of natural origin, we tested the microbicidal activity of Piper aduncum essential oil (PaEO) on this parasite. Our data showed that PaEO had an inhibitory effect on the growth of L. braziliensis promastigotes with an IC50/24 h=77·9 µg mL-1...
May 9, 2017: Parasitology
https://www.readbyqxmd.com/read/28481276/multi-anti-parasitic-activity-of-arylidene-ketones-and-thiazolidene-hydrazines-against-trypanosoma-cruzi-and-leishmania-spp
#7
Guzmán Álvarez, Cintya Perdomo, Cathia Coronel, Elena Aguilera, Javier Varela, Gonzalo Aparicio, Flavio R Zolessi, Nallely Cabrera, Celeste Vega, Miriam Rolón, Antonieta Rojas de Arias, Ruy Pérez-Montfort, Hugo Cerecetto, Mercedes González
A series of fifty arylideneketones and thiazolidenehydrazines was evaluated against Leishmania infantum and Leishmania braziliensis. Furthermore, new simplified thiazolidenehydrazine derivatives were evaluated against Trypanosoma cruzi. The cytotoxicity of the active compounds on non-infected fibroblasts or macrophages was established in vitro to evaluate the selectivity of their anti-parasitic effects. Seven thiazolidenehydrazine derivatives and ten arylideneketones had good activity against the three parasites...
May 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28472733/in-vitro-inhibition-of-leishmania-attachment-to-sandfly-midguts-and-ll-5-cells-by-divalent-metal-chelators-anti-gp63-and-phosphoglycans
#8
Rodrigo Pedro Soares, Ellen Cristina Félix Altoé, Vítor Ennes-Vidal, Simone M da Costa, Elizabeth Ferreira Rangel, Nataly Araújo de Souza, Vanderlei Campos da Silva, Petr Volf, Claudia Masini d'Avila-Levy
Leishmania braziliensis and Leishmania infantum are the causative agents of cutaneous and visceral leishmaniasis, respectively. Several aspects of the vector-parasite interaction involving gp63 and phosphoglycans have been individually assayed in different studies. However, their role under the same experimental conditions was not studied yet. Here, the roles of divalent metal chelators, anti-gp63 antibodies and purified type I phosphoglycans (PGs) were evaluated during in vitro parasite attachment to the midgut of the vector...
March 29, 2017: Protist
https://www.readbyqxmd.com/read/28468680/cd3-cd4-neg-cd8-neg-double-negative-t-lymphocytes-and-nkt-cells-as-the-main-cytotoxic-related-cd107a-cells-in-lesions-of-cutaneous-leishmaniasis-caused-by-leishmania-viannia-braziliensis
#9
Raquel Ferraz, Clarissa F Cunha, Maria Inês F Pimentel, Marcelo R Lyra, Tatiana Pereira-Da-Silva, Armando O Schubach, Alda Maria Da-Cruz, Alvaro Luiz Bertho
BACKGROUND: Cutaneous leishmaniasis (CL) is caused by Leishmania (Viannia) braziliensis, which infects dermal macrophages and dendritic cells, causing an intense immune-mediated-tissue inflammation and a skin ulcer with elevated borders that can heal spontaneously or after antimonial therapy. The resolution of lesions depends on an adaptive immune response, and cytotoxic cells seem to have a fundamental role in this process. The aim of this study is to better understand the role of cytotoxicity mediated mechanisms that occur during the immune response in the CL lesion milieu, considering distinct cytotoxic-related CD107a(+) cells, such as CD8(+), CD4(+), CD4(neg) CD8(neg) (double-negative, DN) and CD4(+)CD8(+) (double-positive, DP) T lymphocytes, as well as NK and NKT cells...
May 3, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28467433/correction-meta-transcriptome-profiling-of-the-human-leishmania-braziliensis-cutaneous-lesion
#10
Stephen M Christensen, Laura A L Dillon, Lucas P Carvalho, Sara Passos, Fernanda O Novais, V Keith Hughitt, Daniel P Beiting, Edgar M Carvalho, Phillip Scott, Najib M El-Sayed, David M Mosser
[This corrects the article DOI: 10.1371/journal.pntd.0004992.].
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28461312/knockdown-of-host-antioxidant-defense-genes-enhances-the-effect-of-glucantime-on-intracellular-leishmania-braziliensis-in-human-macrophages
#11
Jair Téllez, Ibeth Romero, Maurilio José Soares, Mario Steindel, Alvaro José Romanha
Leishmaniasis is a neglected tropical disease affecting millions of people worldwide and represents a major public health problem. Information on protein expression patterns and functional roles within the context of Leishmania-infected human monocyte-derived macrophages (MDMs) under drug treatment conditions are essential to understand the role of these cells in leishmaniasis treatment. We analyzed functional changes in expression of human MDM genes and proteins during in vitro infection by Leishmania braziliensis and treatment with Glucantime (Sb(V)) using quantitative polymerase chain reaction (qPCR) arrays, western blotting, confocal microscopy and short-interfering RNA (siRNA) human gene-inhibition assays...
May 1, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28457848/evaluation-of-methylene-blue-as-photosensitizer-in-promastigotes-of-leishmania-major-and-leishmania-braziliensis
#12
Juliana Guerra Pinto, Jaciara Fagundes, André Henrique Correia Pereira, Josane Mittmann, Leandro José Raniero, Juliana Ferreira-Strixino
The cutaneous leishmaniasis is caused by the protozoan of the genus Leishmania. It is considered by WHO as a public health issue and a neglected disease, which affects rural workers and it is also a risk to travelers in endemic areas. The conventional treatment is toxic and leads to severe side effects. The photodynamic therapy has been studied as an alternative treatment to cutaneous leishmaniasis. This study aimed to evaluate the methylene blue internalization and the impact of the PDT in the viability and morphology of Leishmania major and Leishmania braziliensis promastigote in culture medium...
April 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28397969/aim2-inflammasome-is-associated-to-disease-severity-in-tegumentary-leishmaniasis-caused-by-leishmania-v-braziliensis
#13
Regina Barbosa Moreira, Claude Pirmez, Manoel Paes De Oliveira-Neto, Luana De Souza Aguiar, Antonio José Da Silva Gonçalves, Luiza Oliveira Ramos Pereira, Lais Abreu, Márcia Pereira De Oliveira
The inflammasome is a multiprotein signaling platform involved in the pathogenesis of various inflammatory skin diseases. Herein, we investigated gene and protein expression of the inflammasome molecules AIM2 and NLRP3 in active lesions from patients with L. (V.) braziliensis-associated tegumentary leishmaniasis (TL) and correlated these findings with the clinical presentations and responses to therapy. Real-time PCR assays showed a significantly higher AIM2 gene expression in mucosal leishmaniasis (ML) compared with that in cutanoeus leishmaniasis (CL)...
April 11, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28393067/biophysical-and-pharmacological-characterization-of-energy-dependent-efflux-of-sb-in-laboratory-selected-resistant-strains-of-leishmania-viannia-subgenus
#14
Priscila G Dos Reis, Rubens L do Monte-Neto, Maria N Melo, Frédéric Frézard
The growing resistance of leishmaniasis to first-line drugs like antimonials in some regions limits the control of this parasitic disease. The precise mechanisms involved in Leishmania antimony resistance are still subject to debate. The reduction of intracellular Sb(III) accumulation is a common change observed in both laboratory-selected and field isolated resistant Leishmania strains, but the exact transport pathways involved in antimony resistance have not yet been elucidated. In order to functionally characterize the antimony transport routes responsible for resistance, we performed systematic transport studies of Sb(III) in wild-type and resistant strains of L...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28385540/performance-of-leishmania-braziliensis-enolase-protein-for-the-serodiagnosis-of-canine-and-human-visceral-leishmaniosis
#15
Mariana Costa Duarte, Daniela Pagliara Lage, Vívian Tamietti Martins, Lourena Emanuele Costa, Beatriz Cristina Silveira Salles, Ana Maria Ravena Severino Carvalho, Thaís Teodoro de Oliveira Santos, Daniel Silva Dias, Patrícia Aparecida Fernandes Ribeiro, Miguel Angel Chávez-Fumagalli, Ricardo Andrez Machado-de-Ávila, Bruno Mendes Roatt, Daniel Menezes-Souza, Danielle Ferreira de Magalhães-Soares, Eduardo Antonio Ferraz Coelho
In the present study, Leishmania braziliensis enolase was cloned and the recombinant protein (rEnolase) was evaluated for the serodiagnosis of canine and human visceral leishmaniosis (VL). For the canine VL diagnosis, this study examined serum samples of Leishmania infantum-infected dogs, from non-infected animals living in endemic or non-endemic areas of leishmaniosis, as well as those from Leish-Tec(®)-vaccinated dogs and Trypanosoma cruzi or Ehrlichia canis experimentally infected animals. For the human VL diagnosis, this study analyzed serum samples from VL patients, from non-infected subjects living in endemic or non-endemic areas of leishmaniosis, as well as those from T...
March 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28367781/simple-dialkyl-pyrazole-3-5-dicarboxylates-show-in-vitro-and-in-vivo-activity-against-disease-causing-trypanosomatids
#16
Felipe Reviriego, Francisco Olmo, Pilar Navarro, Clotilde Marín, Inmaculada Ramírez-Macías, Enrique García-España, María Teresa Albelda, Ramón Gutiérrez-Sánchez, Manuel Sánchez-Moreno, Vicente J Arán
The synthesis and antiprotozoal activity of some simple dialkyl pyrazole-3,5-dicarboxylates (compounds 2-6) and their sodium salts (pyrazolates) (compounds 7-9) against Trypanosoma cruzi, Leishmania infantum and Leishmania braziliensis are reported. In most cases the studied compounds showed, especially against the clinically significant amastigote forms, in vitro activities higher than those of the reference drugs (benznidazole for T. cruzi and glucantime for Leishmania spp.); furthermore, the low non-specific cytotoxicities against Vero cells and macrophages shown by these compounds led to good selectivity indexes, which are 8-72 times higher for T...
April 3, 2017: Parasitology
https://www.readbyqxmd.com/read/28367456/synthetic-peptides-as-potential-antigens-for-cutaneous-leishmaniosis-diagnosis
#17
Juliana Seger Link, Silvana Maria Alban, Carlos Ricardo Soccol, Gilberto Vinicius Melo Pereira, Vanete Thomaz Soccol
This work's goal was to research new candidate antigens for cutaneous leishmaniosis (CL). In order to reach the goal, we used random peptide phage display libraries screened using antibodies from Leishmania braziliensis patients. After selection, three peptides (P1, P2, and P3) were synthesized using Fmoc chemistry. The peptides individually or a mixture of them (MIX) was subsequently emulsified in complete and incomplete Freund's adjuvant and injected subcutaneously in golden hamsters. Sera from the hamsters administered with P1 presented antibodies that recognized proteins between 76 and 150 kDa from L...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28340594/species-specific-ecological-niche-modelling-predicts-different-range-contractions-for-lutzomyia-intermedia-and-a-related-vector-of-leishmania-braziliensis-following-climate-change-in-south-america
#18
Shannon McIntyre, Elizabeth F Rangel, Paul D Ready, Bruno M Carvalho
BACKGROUND: Before 1996 the phlebotomine sand fly Lutzomyia neivai was usually treated as a synonym of the morphologically similar Lutzomyia intermedia, which has long been considered a vector of Leishmania braziliensis, the causative agent of much cutaneous leishmaniasis in South America. This report investigates the likely range changes of both sand fly species in response to a stabilisation climate change scenario (RCP4.5) and a high greenhouse gas emissions one (RCP8.5). METHODS: Ecological niche modelling was used to identify areas of South America with climates currently suitable for each species, and then the future distributions of these climates were predicted based on climate change scenarios...
March 24, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28327794/seasonality-of-sand-flies-diptera-psychodidae-and-leishmania-dna-detection-in-vector-species-in-an-area-with-endemic-visceral-leishmaniasis
#19
Lara Saraiva, Camila Gonçalves Leite, Ana Cristina Vianna Mariano da Rocha Lima, Luiz Otávio Alves de Carvalho, Agnes Antônia Sampaio Pereira, Jerônimo Marteleto Nunes Rugani, Felipe Dutra Rego, Célia Maria Ferreira Gontijo, José Dilermando Andrade
BACKGROUND: Leishmaniases are a serious health problem in southeast Brazil, including the city of Belo Horizonte (BH), Minas Gerais state (MG), where there are high rates of incidence and mortality due to visceral leishmaniases. BH is divided into nine sanitary districts (SD) of which one, the Venda Nova SD, was selected for this study because it has high rates of positivity for canine leishmaniasis and high incidence of human leishmaniasis. OBJECTIVES: This study aimed to survey the sand fly fauna in Venda Nova SD from August 2011 to July 2013 and perform a descriptive analysis of the vector population...
April 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28321217/a-vaccine-therapy-for-canine-visceral-leishmaniasis-promoted-significant-improvement-of-clinical-and-immune-status-with-reduction-in-parasite-burden
#20
Bruno Mendes Roatt, Rodrigo Dian de Oliveira Aguiar-Soares, Levi Eduardo Soares Reis, Jamille Mirelle de Oliveira Cardoso, Fernando Augusto Siqueira Mathias, Rory Cristiane Fortes de Brito, Sydnei Magno da Silva, Nelder De Figueiredo Gontijo, Sidney de Almeida Ferreira, Jesus G Valenzuela, Rodrigo Corrêa-Oliveira, Rodolfo Cordeiro Giunchetti, Alexandre Barbosa Reis
Herein, we evaluated the treatment strategy employing a therapeutic heterologous vaccine composed of antigens of Leishmania braziliensis associated with MPL adjuvant (LBMPL vaccine) for visceral leishmaniasis (VL) in symptomatic dogs naturally infected by Leishmania infantum. Sixteen dogs received immunotherapy with MPL adjuvant (n = 6) or with a vaccine composed of antigens of L. braziliensis associated with MPL (LBMPL vaccine therapy, n = 10). Dogs were submitted to an immunotherapeutic scheme consisting of 3 series composed of 10 subcutaneous doses with 10-day interval between each series...
2017: Frontiers in Immunology
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