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Leishmania braziliensis

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https://www.readbyqxmd.com/read/29340456/new-strategy-to-improve-quality-control-of-montenegro-skin-test-at-the-production-level
#1
Deborah Carbonera Guedes, João Carlos Minozzo, Aline Kuhn Sbruzzi Pasquali, Craig Faulds, Carlos Ricardo Soccol, Vanete Thomaz-Soccol
INTRODUCTION: The production of the Montenegro antigen for skin test poses difficulties regarding quality control. Here, we propose that certain animal models reproducing a similar immune response to humans may be used in the quality control of Montenegro antigen production. METHODS: Fifteen Cavia porcellus (guinea pigs) were immunized with Leishmania amazonensis or Leishmania braziliensis , and, after 30 days, they were skin tested with standard Montenegro antigen...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29329207/arnica-tincture-cures-cutaneous-leishmaniasis-in-golden-hamsters
#2
Sara M Robledo, Ivan D Vélez, Thomas J Schmidt
In search for potential therapeutic alternatives to existing treatments for cutaneous Leishmaniasis, we have investigated the effect of Arnica tincture Ph. Eur. (a 70% hydroethanolic tincture prepared from flowerheads of Arnica montana L.) on the lesions caused by infection with Leishmania braziliensis in a model with golden hamsters. The animals were treated topically with a daily single dose of the preparation for 28 days. Subsequently, the healing process was monitored by recording the lesion size in intervals of 15 days up to day 90...
January 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29304092/dipeptidyl-peptidase-3-a-novel-protease-from-leishmania-braziliensis
#3
Jenny R Diaz, Cesar A Ramírez, Paola A Nocua, Fanny Guzman, José M Requena, Concepción J Puerta
The increase of leishmaniasis cases worldwide and the emergence of Leishmania strains resistant to current treatments make necessary to find new therapeutic targets. Proteases are appealing drug targets because they play pivotal roles in facilitating parasite survival and promoting pathogenesis. Enzymes belonging to the dipeptidyl peptidase 3 (DPP3) group have been described in different organisms such as mammals, insects and yeast, in which these enzymes have been involved in both protein turnover and protection against oxidative damage...
2018: PloS One
https://www.readbyqxmd.com/read/29289564/a-simple-empirical-algorithm-to-distinguish-among-leishmania-braziliensis-major-and-tropica-species-by-maldi-tof-mass-spectrometry
#4
David L Evers, Franz A Frye, Peter J Weina
This work developed a simple empirical algorithm to distinguish three Leishmania species using MALDI-TOF mass spectrometry. It suggests that complicated computer algorithms may not always be necessary for clinically useful microbiology applications.
December 28, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29284049/leishmania-viannia-braziliensis-infection-in-wild-small-mammals-in-ecotourism-area-of-brazil
#5
Gabriel Barbosa Tonelli, Aline Tanure, Felipe Dutra Rego, Gustavo Mayr de Lima Carvalho, Rodolfo Stumpp, Gabriela Ribeiro Ássimos, Aldenise Martins Campos, Ana Cristina Viana Mariano da Rocha Lima, Célia Maria Ferreira Gontijo, Gustavo Fontes Paz, José Dilermando Andrade Filho
Leishmaniases are parasitic diseases transmitted to mammalian hosts by sand fly vectors (Diptera: Psychodidae). Despite the increasing occurrence of visceral and cutaneous leishmaniasis cases in urban centers, their transmission still occur primarily in wild environments and may be associated with professional activities and recreation, such as ecotourism. The Reserva Particular do Patrimônio Natural Santuário do Caraça (RPPNSC) is one of the largest ecotourism attractions in the State of Minas Gerais, Brazil, and comprises an area of environmental preservation with 11,233 hectares presenting a transitional vegetation between Cerrado and Atlantic Forest...
2017: PloS One
https://www.readbyqxmd.com/read/29281707/inhibitory-activity-of-pentacyano-isoniazid-ferrate-ii-iqg-607-against-promastigotes-and-amastigotes-forms-of-leishmania-braziliensis
#6
Camila F Amorim, Luiza Galina, Natália B Carvalho, Nathalia D M Sperotto, Kenia Pissinate, Pablo Machado, Maria M Campos, Luiz A Basso, Valnês S Rodrigues-Junior, Edgar M Carvalho, Diógenes Santiago Santos
M. tuberculosis and parasites of the genus Leishmania present the type II fatty acid biosynthesis system (FASII). The pentacyano(isoniazid)ferrate(II) compound, named IQG-607, inhibits the enzyme 2-trans-enoyl-ACP(CoA) reductase from M. tuberculosis, a key component in the FASII system. Here, we aimed to evaluate the inhibitory activity of IQG-607 against promastigote and amastigote forms of Leishmania (Viannia) braziliensis isolated from patients with different clinical forms of L. braziliensis infection, including cutaneous, mucosal and disseminated leishmaniasis...
2017: PloS One
https://www.readbyqxmd.com/read/29281057/detection-of-leishmania-dna-and-blood-meal-identification-in-sand-flies-diptera-psychodidae-from-len%C3%A3-ois-maranhenses-national-park-region-brazil
#7
Raquel Silva Fonteles, Adalberto Alves Pereira Filho, Jorge Luiz Pinto Moraes, Silma Regina Ferreira Pereira, Bruno Leite Rodrigues, José Manuel Macário Rebêlo
To elucidate portions of the transmission cycles of American tegumentary leishmaniasis (TL) and visceral leishmaniasis (VL) occurring in the region surrounding the Lençóis Maranhenses National Park, an important tourist center in Brazil, the present study objectives were to determine the rate of natural infection by Leishmania spp. and the blood meal in caught sand flies species in the region. Sand flies were captured over 36 mo in 62 locations of the municipality of Barreirinhas, Maranhão with notifications of disease incidence...
December 21, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29280072/new-primers-for-the-detection-leishmania-species-by-multiplex-polymerase-chain-reaction
#8
Carolina Cella Conter, Maria Valdrinez Campana Lonardoni, Sandra Mara Alessi Aristides, Rosilene Fressatti Cardoso, Thaís Gomes Verzignassi Silveira
Leishmaniasis is caused by protozoa of the Leishmania genus, which is divided into subgenus Viannia and Leishmania. In humans, the course of infection largely depends on the host-parasite relationship and primarily of the infective species. The objective of the present study was to design specific primers to the identification of Leishmania species using multiplex PCR. Four primers were designed, based on the GenBank sequences of the kDNA minicircle, amplifying 127 bp for subgenus Viannia, 100 bp for L. amazonensis, and 60 bp for Leishmania donovani complex and L...
December 26, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29273719/resequencing-of-the-leishmania-infantum-strain-jpcm5-genome-and-de-novo-assembly-into-36-contigs
#9
Sandra González-de la Fuente, Ramón Peiró-Pastor, Alberto Rastrojo, Javier Moreno, Fernando Carrasco-Ramiro, Jose M Requena, Begoña Aguado
Leishmania parasites are the causative of leishmaniasis, a group of potentially fatal human diseases. Control strategies for leishmaniasis can be enhanced by genome based investigations. The publication in 2005 of the Leishmania major genome sequence, and two years later the genomes for the species Leishmania braziliensis and Leishmania infantum were major milestones. Since then, the L. infantum genome, although highly fragmented and incomplete, has been used widely as the reference genome to address whole transcriptomics and proteomics studies...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29258569/leishmania-braziliensis-scd6-and-rbp42-proteins-two-factors-with-rna-binding-capacity
#10
Paola A Nocua, Cesar A Ramirez, José M Requena, Concepción J Puerta
BACKGROUND: The study of RNA binding proteins (RBPs) is of great relevance for understanding processes like post-transcriptional control of gene expression. The post-transcriptional mechanisms are particularly important in Leishmania parasites and related trypanosomatids since transcriptional regulation is almost absent in them. Thus, RBPs should be essential during the development of these parasites and for survival strategies against the adverse conditions that they face during their life-cycle...
December 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29246797/il-1%C3%AE-production-by-intermediate-monocytes-is-associated-with-immunopathology-in-cutaneous-leishmaniasis
#11
Daniela Santos, Taís M Campos, Maíra Saldanha, Sergio C Oliveira, Mauricio Nascimento, Dario S Zamboni, Paulo R Machado, Sérgio Arruda, Phillip Scott, Edgar M Carvalho, Lucas P Carvalho
Cutaneous leishmaniasis due to Leishmania braziliensis infection is an inflammatory disease which skin ulcer development is associated with mononuclear cells infiltrate and high levels of inflammatory cytokines production. Recently, NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation and IL-1β production has been associated with increased pathology in murine cutaneous leishmaniasis. We hypothesized that cutaneous leishmaniasis patients have increased expression of NLRP3 leading to high levels of IL-1β production...
December 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29236928/leishmanicidal-compounds-of-nectria-pseudotrichia-an-endophytic-fungus-isolated-from-the-plant-caesalpinia-echinata-brazilwood
#12
Betania Barros Cota, Luiza Guimarães Tunes, Daniela Nabak Bueno Maia, Jonas Pereira Ramos, Djalma Menezes de Oliveira, Markus Kohlhoff, Tânia Maria de Almeida Alves, Elaine Maria Souza-Fagundes, Fernanda Fraga Campos, Carlos Leomar Zani
BACKGROUND In a screen of extracts from plants and fungi to detect antileishmanial activity, we found that the ethyl acetate extract of the fungus Nectria pseudotrichia, isolated from the tree Caesalpinia echinata (Brazilwood), is a promising source of bioactive compounds. OBJECTIVES The aims of this study were to isolate and determine the chemical structures of the compounds responsible for the antileishmanial activity of the organic extract from N. pseudotrichia. METHODS Compounds were isolated by chromatographic fractionation using semi-preparative high-performance liquid chromatography, and their chemical structures were determined by analytical and spectral data and by comparison with published data...
February 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29232388/more-than-the-eyes-can-see-the-worrying-scenario-of-canine-leishmaniasis-in-the-brazilian-side-of-the-triple-border
#13
Vanete Thomaz Soccol, Aline Kuhn Sbruzzi Pasquali, Eliane Maria Pozzolo, André de Souza Leandro, Luciana Chiyo, Rafael Antunes Baggio, Mario Sergio Michaliszyn, Carlos Silva, Patrícia Hoerner Cubas, Ricardo Peterlle, Otacilio Lopes de Souza Paz, Ivana Lucia Belmonte, Alceu Bisetto-Junior
A cross-sectional epidemiological study in the extreme-west of the state of Paraná was carried out to access the prevalence, distribution, and risk variables of canine Visceral Leishmaniases (cVL). This study was conducted in three areas, two cities of far west of Parana state: Foz do Iguaçu (FI) and Santa Terezinha de Itaipu (STI), and along two transects between these two municipalities. To sample the entire urban area, the cities (FI and STI) were divided into a grid of squares of 400 m2 (patch). Among the 526 patches, 123 in FI, 40 in the transects and 33 in STI were selected according to the 'worst scenario' criterion...
2017: PloS One
https://www.readbyqxmd.com/read/29230580/in-vivo-studies-of-the-effectiveness-of-novel-n-halomethylated-and-non-halomethylated-quaternary-ammonium-salts-in-the-topical-treatment-of-cutaneous-leishmaniasis
#14
Maritza Fernandez, Javier Murillo, Luz Amalia Ríos-Vásquez, Rogelio Ocampo-Cardona, David L Cedeño, Marjorie A Jones, Iván D Velez, Sara M Robledo
The physicochemical properties of four N-halomethylated and one non-halomethylated ammonium salts, with proven in vitro antileishmanial activity, were determined according to pharmaceutical standard procedures. The effectiveness and toxicity of these compounds were assessed in hamsters infected with Leishmania (Viannia) braziliensis and compared to that showed by meglumine antimoniate. Animals were followed during 90 days after the completion of treatment. Therapeutic response was determined according to the reduction of size of skin lesions...
December 11, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29224978/andean-cutaneous-leishmaniasis-andean-cl-uta-in-peru-and-ecuador-the-vector-lutzomyia-sand-flies-and-reservoir-mammals
#15
REVIEW
Yoshihisa Hashiguchi, Eduardo A Gomez L, Abraham G Cáceres, Lenin N Velez, Nancy V Villegas, Kazue Hashiguchi, Tatsuyuki Mimori, Hiroshi Uezato, Hirotomo Kato
The vector Lutzomyia sand flies and reservoir host mammals of the Leishmania parasites, causing the Andean cutaneous leishmaniasis (Andean-CL, uta) in Peru and Ecuador were thoroughly reviewed, performing a survey of literatures including our unpublished data. The Peruvian L. (V.) peruviana, a principal Leishmania species causing Andean-CL in Peru, possessed three Lutzomyia species, Lu. peruensis, Lu. verrucarum and Lu. ayacuchensis as vectors, while the Ecuadorian L. (L.) mexicana parasite possessed only one species Lu...
December 7, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29220437/leishdb-a-database-of-coding-gene-annotation-and-non-coding-rnas-in-leishmania-braziliensis
#16
Felipe Torres, Raúl Arias-Carrasco, José C Caris-Maldonado, Aldina Barral, Vinicius Maracaja-Coutinho, Artur T L De Queiroz
www.leishdb.com.
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29216363/early-cutaneous-leishmaniasis-patients-infected-with-leishmania-braziliensis-express-increased-inflammatory-responses-following-antimony-therapy
#17
Rúbia S Costa, Lucas P Carvalho, Taís M Campos, Andréa S Magalhães, Sara T Passos, Albert Schriefer, Juliana A Silva, Ednaldo Lago, Camilla S Paixão, Paulo Machado, Phillip Scott, Edgar M Carvalho
Background: Early cutaneous leishmaniasis (ECL) is characterized by a non-ulcerated papular lesion and illness duration less than 30 days. About 4 weeks later the cutaneous leishmaniasis (CL) ulcers appear. Surprisingly, failure following antimony therapy (Sb5) is higher in ECL than CL. We hypothesize that the inflammatory response in ECL patients may increase during Sb5 therapy leading to treatment failure. Methods: A cohort of 44 ECL patients infected by Leishmaniabraziliensis was established to evaluate the response to Sb5, and to compare immunologic responses in ECL patients with CL and healthy subjects (HS)...
December 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29213084/emerging-role-for-the-perk-eif2%C3%AE-atf4-in-human-cutaneous-leishmaniasis
#18
Karina Luiza Dias-Teixeira, Teresa C Calegari-Silva, Jorge M Medina, Áislan C Vivarini, Átila Cavalcanti, Nataly Teteo, Alynne Karen M Santana, Fernando Real, Ciro M Gomes, Renata Meirelles Santos Pereira, Nicolas Fasel, João S Silva, Bertal H Aktas, Ulisses G Lopes
Leishmania parasites utilize adaptive evasion mechanisms in infected macrophages to overcome host defenses and proliferate. We report here that the PERK/eIF2α/ATF4 signaling branch of the integrated endoplasmic reticulum stress response (IERSR) is activated by Leishmania and this pathway is important for Leishmania amazonensis infection. Knocking down PERK or ATF4 expression or inhibiting PERK kinase activity diminished L. amazonensis infection. Knocking down ATF4 decreased NRF2 expression and its nuclear translocation, reduced HO-1 expression and increased nitric oxide production...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29204144/all-trans-retinoic-acid-promotes-an-m1-to-m2-phenotype-shift-and-inhibits-macrophage-mediated-immunity-to-leishmania-major
#19
Natália S Vellozo, Sâmara T Pereira-Marques, Mariela P Cabral-Piccin, Alessandra A Filardy, Flávia L Ribeiro-Gomes, Thaís S Rigoni, George A DosReis, Marcela F Lopes
As key cells, able to host and kill Leishmania parasites, inflammatory monocytes/macrophages are potential vaccine and therapeutic targets to improve immune responses in Leishmaniasis. Macrophage phenotypes range from M1, which express NO-mediated microbial killing, to M2 macrophages that might help infection. Resistance to Leishmaniasis depends on Leishmania species, mouse strain, and both innate and adaptive immunity. C57BL/6 (B6) mice are resistant and control infection, whereas Leishmania parasites thrive in BALB/c mice, which are susceptible to develop cutaneous lesions in the course of infection with Leishmania major, but not upon infection with Leishmania braziliensis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29197260/susceptibility-of-dendritic-cells-from-individuals-with-schistosomiasis-to-infection-by-leishmania-braziliensis
#20
Diego Mota Lopes, Tarcísio Vila Verde S de Almeida, Robson da Paixão de Souza, Luís Eduardo Viana Ribeiro, Brady Page, Jamille de Souza Fernandes, Edgar M Carvalho, Luciana Santos Cardoso
Coinfection with leishmaniasis and schistosomiasis has been associated with increased time to healing of cutaneous lesions of leishmaniasis. The objective of this study was to evaluate the effect of Leishmania braziliensis infection on co-cultures of monocyte-derived dendritic cells (MoDCs) with autologous lymphocytes from patients with schistosomiasis and patients with cutaneous leishmaniasis. MoDCs were differentiated from peripheral blood monocytes, isolated by magnetic beads, infected with L. braziliensis, and co-cultured with autologous lymphocytes...
November 29, 2017: Molecular Immunology
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