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Leishmania braziliensis

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https://www.readbyqxmd.com/read/27886396/5-ala-mediated-photodynamic-therapy-reduces-the-parasite-load-in-mice-infected-with-leishmania-braziliensis
#1
Danila Malheiros Souza, Polyanna Miranda Alves, Mona Lisa Fabiana Silva, Tony Paiva Paulino, Henrique Ovidio Coraspe, Mônica Miguel Sawan Mendonça, Betânia Maria Ribeiro, Marcos Vinicius da Silva, Virmondes Rodrigues Júnior, Denise Bertulucci Rocha Rodrigues
INTRODUCTION: Photodynamic therapy (PDT) has proven to be an effective alternative for the treatment of cutaneous leishmaniasis. Skin lesions consist of ulcers with well-defined raised edges, and granular floor. Th1 immune response is the protective profile in patients infected with Leishmania. In the present study, the photodynamic therapy with 5-aminolevulinic acid, the parasitic load, and the modulation of the immune response were evaluated in mice infected with Leishmania braziliensis...
November 25, 2016: Parasite Immunology
https://www.readbyqxmd.com/read/27870860/gene-expression-profile-of-high-ifn-%C3%AE-producers-stimulated-with-leishmania-braziliensis-identifies-genes-associated-with-cutaneous-leishmaniasis
#2
Marcia W Carneiro, Kiyoshi F Fukutani, Bruno B Andrade, Rebecca P Curvelo, Juqueline R Cristal, Augusto M Carvalho, Aldina Barral, Johan Van Weyenbergh, Manoel Barral-Netto, Camila I de Oliveira
BACKGROUND: The initial response to Leishmania parasites is essential in determining disease development or resistance. In vitro, a divergent response to Leishmania, characterized by high or low IFN-γ production has been described as a potential tool to predict both vaccine response and disease susceptibility in vivo. METHODS AND FINDINGS: We identified uninfected and healthy individuals that were shown to be either high- or low IFN-γ producers (HPs and LPs, respectively) following stimulation of peripheral blood cells with Leishmania braziliensis...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27860021/detection-of-leishmania-amazonensis-and-leishmania-braziliensis-in-culicoides-diptera-ceratopogonidae-in-an-endemic-area-of-cutaneous-leishmaniasis-in-the-brazilian-amazonia
#3
José Manuel Macário Rebêlo, Bruno Leite Rodrigues, Maria da Conceição Abreu Bandeira, Jorge Luiz Pinto Moraes, Raquel Silva Fonteles, Silma Regina Ferreira Pereira
Biting midges in the genus Culicoides act as vectors of arboviruses throughout the world and as vectors of filariasis in Latin America, the Caribbean, and parts of Africa. Although Culicoides spp. are currently not considered to be vectors of Leishmania protozoa, the high abundance of biting midges in areas with active cutaneous leishmaniasis transmission points to the possibility of Culicoides infection by these pathogens. We used PCR to test captured Culicoides species for natural infection with Leishmania spp...
December 2016: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/27849219/genomic-and-phylogenetic-evidence-of-viper-retrotransposon-domestication-in-trypanosomatids
#4
Adriana Ludwig, Marco Aurelio Krieger
Transposable elements are important residents of eukaryotic genomes and eventually the host can domesticate them to serve cellular functions. We reported here a possible domestication event of the vestigial interposed retroelement (VIPER) in trypanosomatids. We found a large gene in a syntenic location in Leishmania braziliensis, L. panamensis, Leptomanas pyrrhocoris, and Crithidia fasciculata whose products share similarity in the C-terminal portion with the third protein of VIPER. No remnants of other VIPER regions surrounding the gene sequence were found...
November 16, 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27845489/leishmaniasis-and-ifn-%C3%AE-dependent-chemokines
#5
P Fallahi, G Elia, A Bonatti
Leishmaniasis is a disease caused by Leishmania and spread by the bite of certain types of sandflies. Leishmaniasis affects as many as 12 million people worldwide, with 2 million new cases each year. Leishmania infection, and Leishmaniasis, following occupational exposure has been also reported. Three forms of Leishmaniasis are known: a- Cutaneous Leishmaniasis (CL); b-Mucocutaneous Leishmaniasis; c- Visceral Leishmaniasis (VL). The visceral form of Leishmaniasis has an estimated incidence of 500,000 new cases...
September 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/27812653/evaluation-of-the-antiplasmodial-and-leishmanicidal-potential-of-myrciaria-dubia-myrtaceae-extract
#6
Vanessa Carolina de Sena Correia, Nathália Oliveira Lima, Flávio Augusto de Souza Oliveira, Ana Paula de Azevedo Dos Santos, Carolina Bioni Garcia Teles, Waldesse Piragé de Oliveira, And Raphael Sanzio Pimenta
INTRODUCTION: Malaria and leishmaniasis are prevalent in tropical regions, which have environmental characteristics that are highly favorable to protozoa and vectors of these diseases; the transmission of these infections in sub-tropical regions, although recognized, represents only a small fraction of cases. Plants are constantly being used in the search for and acquisition of new drugs, and many compounds derived from them have been used to combat various diseases. In this study, we evaluated the action of the dichloromethanolic extract of Myrciaria dubia leaves against the protozoa Plasmodium falciparum, Leishmania amazonensis, Leishmania braziliensis, and Leishmania chagasi through bioassays...
September 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27812113/immunity-to-lutzomyia-whitmani-saliva-protects-against-experimental-leishmania-braziliensis-infection
#7
Regis Gomes, Katrine Cavalcanti, Clarissa Teixeira, Augusto M Carvalho, Paulo S Mattos, Juqueline R Cristal, Aline C Muniz, José Carlos Miranda, Camila I de Oliveira, Aldina Barral
BACKGROUND: Previous works showed that immunization with saliva from Lutzomyia intermedia, a vector of Leishmania braziliensis, does not protect against experimental infection. However, L. braziliensis is also transmitted by Lutzomyia whitmani, a sand fly species closely related to Lu. intermedia. Herein we describe the immune response following immunization with Lu. whitmani saliva and the outcome of this response after L. braziliensis infection. METHODS AND FINDINGS: BALB/c mice immunized with Lu...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27808385/standardization-of-a-molecular-method-for-epidemiologic-identification-of-leishmania-strains
#8
R F Rocha, E V Menezes, A R E O Xavier, V A Royo, D A Oliveira, A F M Júnior, E S Dias, A C V M R Lima, E M Michalsky
Molecular studies of the evolutionary relationships among Leishmania species suggest the presence of high genetic variation within this genus, which has a direct effect on public health in many countries. The coexistence of species in a particular region can result in different leishmaniasis clinical forms and treatment responses. We aimed to standardize the kinetoplast DNA (kDNA) enterobacterial repetitive intergenic consensus (ERIC) sequence polymerase chain reaction (PCR) method for molecular epidemiological identification of Leishmania strains, and estimate existing inter-strain genomic differences and kDNA signatures using this technique...
October 6, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27803094/fluconazole-in-the-treatment-of-cutaneous-leishmaniasis-caused-by-leishmania-braziliensis-a-randomized-controlled-trial
#9
Fernanda V de O Prates, Mayra E F Dourado, Silvana C Silva, Albert Schriefer, Luiz H Guimarães, Maria das Graças O Brito, Juliana Almeida, Edgar M Carvalho, Paulo R L Machado
BACKGROUND:  The treatment of cutaneous leishmaniasis (CL) caused by Leishmania braziliensis in Brazil with pentavalent antimony (Sb(v)) is associated with a high rate of failure, up to 45% of cases. In addition, Sb(v) can only administered parenterally and has important toxic effect. An effective, safe, and oral treatment for CL is required. METHODS:  A randomized controlled clinical trial was conducted to compare the efficacy and safety of high-dosage oral fluconazole (6...
November 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27799649/sclerosing-orbital-inflammation-caused-by-leishmania-braziliensis
#10
Antonio Augusto V Cruz, Eliza V C Alves-Ferreira, Gherusa Milbratz-Moré, Fernando Chahud, Patricia C Ruy, Maria Irma Seixas Duarte, Angela Kaysel Cruz
Orbital biopsy of nonspecific orbital inflammation, commonly referred to as "orbital pseudotumor," typically shows a combination of polyclonal lymphocytes, plasmocytes, leukocytes, macrophages, and variable degrees of collagen deposition. Herein, we report a patient with a positive history of mucocutaneous leishmaniasis who presented with an orbital mass with a histological profile of idiopathic orbital inflammation. Immunohistochemical and molecular analysis of the orbital specimens demonstrated that the orbital inflammation was associated with the presence of antigens of Leishmania braziliensis and DNA from the parasite...
October 31, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27790981/tilting-the-balance-between-rna-interference-and-replication-eradicates-leishmania-rna-virus-1-and-mitigates-the-inflammatory-response
#11
Erin A Brettmann, Jahangheer S Shaik, Haroun Zangger, Lon-Fye Lye, F Matthew Kuhlmann, Natalia S Akopyants, Dayna M Oschwald, Katherine L Owens, Suzanne M Hickerson, Catherine Ronet, Nicolas Fasel, Stephen M Beverley
Many Leishmania (Viannia) parasites harbor the double-stranded RNA virus Leishmania RNA virus 1 (LRV1), which has been associated with increased disease severity in animal models and humans and with drug treatment failures in humans. Remarkably, LRV1 survives in the presence of an active RNAi pathway, which in many organisms controls RNA viruses. We found significant levels (0.4 to 2.5%) of small RNAs derived from LRV1 in both Leishmania braziliensis and Leishmania guyanensis, mapping across both strands and with properties consistent with Dicer-mediated cleavage of the dsRNA genome...
October 25, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27789199/quinoline-derivatives-synthesis-leishmanicidal-activity-and-involvement-of-mitochondrial-oxidative-stress-as-mechanism-of-action
#12
Elaine S Coimbra, Luciana M R Antinarelli, Natália P Silva, Isabela O Souza, Raissa S Meinel, Marcele N Rocha, Rodrigo P P Soares, Adilson D da Silva
Leishmaniasis comprise a spectrum of diseases caused by protozoa parasites from the genus Leishmania, affecting millions of people worldwide, mainly in subtropical countries. Most antileishmanial drugs are highly toxic, present resistance issues or require long-term treatment. Consequently, new drugs are urgently needed. Quinoline-containing compounds have displayed an impressive array of biological properties over the years, including antileishmanial activity. In the present study, we report the synthesis and evaluation of novel quinoline derivatives (QuinDer) against Leishmania species and cytotoxic effect on mammalian cells...
October 24, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27761403/rangelia-vitalii-in-a-free-ranging-maned-wolf-chrysocyon-brachyurus-and-co-infections
#13
Julia Angélica Gonçalves Silveira, Mirella Lauria D'Elia, Isabela de Oliveira Avelar, Lara Ribeiro de Almeida, Hudson Andrade Dos Santos, Danielle Ferreira de Magalhães Soares, Múcio Flávio Barbosa Ribeiro, Walter Dos Santos Lima, Roselene Ecco
An adult free-ranged female maned wolf was rescued from a periurban area subject to anthropogenic disturbances in the Minas Gerais, Brazil. The animal presented poor body condition and anemia. The clinical condition rapidly deteriorated culminating in dead and a necropsy was performed. The main gross lesions were marked anemia and blood content in the intestines accompanied by many types of parasites. The protozoa Rangelia vitalii was identified by histopathological analysis predominantly within the cytoplasm of endothelial cells of capillaries of the small intestine...
December 2016: International Journal for Parasitology. Parasites and Wildlife
https://www.readbyqxmd.com/read/27729245/effectiveness-of-an-immunohistochemical-protocol-for-leishmania-detection-in-different-clinical-forms-of-american-tegumentary-leishmaniasis
#14
Fernanda A Marques, Rodrigo P Soares, Gregório G Almeida, Carolina C Souza, Maria N Melo, Sebastião A Pinto, Valeria B Quixabeira, Ledice I Pereira, Miriam L Dorta, Fatima Ribeiro-Dias, Fernando T Silveira, Sydnei M Silva, Celia M Gontijo, Wagner L Tafuri
American tegumentary leishmaniasis (ATL) is a neglected disease widely distributed in Latin America. In Brazil, it is caused by different Leishmania species belonging to the Subgenera Viannia and Leishmania. ATL diagnosis is routinely based on clinical, epidemiological, parasitological and immunological (delayed-type hypersensitivity skin test-DTH) evidences. The main objective of this work was to determine the efficacy of a previous immunohistochemical (IHC) method developed by our group. Seventy eight skin biopsies from patients with different ATL clinical forms and origins were evaluated...
October 8, 2016: Parasitology International
https://www.readbyqxmd.com/read/27713019/galleria-mellonella-hemocytes-a-novel-phagocytic-assay-for-leishmania-viannia-braziliensis
#15
Fernanda Tomiotto-Pellissier, Allan Henrique Depieri Cataneo, Tatiane Marcuso Orsini, Ana Paula Fortes Dos Santos Thomazelli, Gabriela Alcântara Dalevedo, Admilton Gonçalves de Oliveira, Luciano Aparecido Panagio, Idessania Nazareth Costa, Ivete Conchon-Costa, Wander Rogério Pavanelli, Ricardo Sergio Almeida
Galleria mellonella is an excellent invertebrate model for the study of diseases that involve interactions with cells from the innate immune system, since they have an innate immune system capable of recognizing the pathogens. Here we present for the first time, an alternative model for an in vitro phagocytic assay using hemocytes of G. mellonella larvae to study infection by Leishmania (Viannia) braziliensis. We showed that the insect phagocytic cells were able to engulf promastigotes. Furthermore, this infective form differentiated into the amastigote form inside those cells...
October 3, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27706707/diagnosis-and-epidemiology-of-canine-leishmaniasis-in-southeastern-bahia-brazil
#16
T N A Oliveira, P E B Guedes, G B Souza, F S Carvalho, R S Alberto Carlos, G R Albuquerque, A D Munhoz, F L Silva
Leishmaniasis is a disease caused by protozoa of the genus Leishmania. Two distinct forms are recognized: visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). In the Americas, the causative agent of VL is L. infantum chagasi, whereas L. braziliensis is principally responsible for CL. Domestic dogs constitute the main source of VL in urban environments, and have also been implicated in CL epidemiology. We carried out molecular and serological surveys to detect Leishmania infection in dogs from the municipality of Ituberá in Bahia, Brazil...
September 2, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27702443/brazilian-propolis-promotes-immunomodulation-on-human-cells-from-american-tegumentar-leishmaniasis-patients-and-healthy-donors-infected-with-l-braziliensis
#17
Ana Paula Fortes Dos Santos Thomazelli, Fernanda Tomiotto-Pellissier, Suelen Santos da Silva, Carolina Panis, Tatiane Marcusso Orsini, Allan Henrique Depieri Cataneo, Milena Menegazzo Miranda-Sapla, Luiz Antonio Custódio, Vera Lúcia Hideko Tatakihara, Juliano Bordignon, Guilherme Ferreira Silveira, José Maurício Sforcin, Wander Rogério Pavanelli, Ivete Conchon-Costa
American Tegumentar Leishmaniasis (ATL) is an infectious disease caused by Leishmania parasites with ineffective treatment. The properties of propolis have been studied in different experimental studies, however, few works have investigated the effects of propolis on human-derived peripheral blood mononuclear cells (PBMC) in leishmaniasis models. Thus, we investigate the immunomodulatory effects of propolis treatment on PBMC from ATL patients and on PBMC from healthy donors infected with Leishmania braziliensis...
September 29, 2016: Cellular Immunology
https://www.readbyqxmd.com/read/27693018/a-vaccine-composed-of-a-hypothetical-protein-and-the-eukaryotic-initiation-factor-5a-from-leishmania-braziliensis-cross-protection-against-leishmania-amazonensis-infection
#18
Mariana Costa Duarte, Daniela Pagliara Lage, Vívian Tamietti Martins, Lourena Emanuele Costa, Ana Maria Ravena Severino Carvalho, Fernanda Ludolf, Thaís Teodoro de Oliveira Santos, Danniele Luciana Vale, Bruno Mendes Roatt, Daniel Menezes-Souza, Ana Paula Fernandes, Carlos Alberto Pereira Tavares, Eduardo Antonio Ferraz Coelho
In the present study, two proteins cloned from Leishmania braziliensis species, a hypothetical protein (LbHyp) and the eukaryotic initiation factor 5a (EiF5a), were evaluated to protect BALB/c mice against L. amazonensis infection. The animals were immunized with the antigens, either separately or in combination, using saponin as an immune adjuvant in both cases. Spleen cells from vaccinated and later infected mice produced significantly higher levels of protein and parasite-specific IFN-γ, IL-12, and GM-CSF, in addition to low levels of IL-4 and IL-10...
September 28, 2016: Immunobiology
https://www.readbyqxmd.com/read/27691942/leishmania-spp-in-didelphis-spp-from-northeastern-brazil
#19
Edson Moura Silva, Leucio Câmara Alves, Neurisvan Ramos Guerra, Márcia Paula Oliveira Farias, Elton Luiz Ritir Oliveira, Ricardo César de Souza, Carneiro da Cunha, Rafael Antonio Nascimento Ramos, Wagnner José Nascimento Porto
The synanthropic behavior of marsupials of the genus Didelphis in endemic areas of leishmaniasis suggests that these animals may play an important role in the epidemiology of this infection. The aim of the present study was to detect Leishmania spp. DNA in Didelphis albiventris (white-eared opossum) and Didelphis aurita (big-eared opossum) living in forested and peridomestic areas of northeastern Brazil. Blood samples were collected from 25 animals (23 D. albiventris and 2 D. aurita ) by cardiac puncture and then analyzed via PCR...
September 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/27688269/nycthemeral-rhythm-of-phlebotominae-diptera-psychodidae-in-a-craggy-region-transitioning-between-the-wetland-and-the-plateau-brazil
#20
J O M Infran, D A Souza, W S Fernandes, A E Casaril, G U Eguchi, E T Oshiro, C E S Fernandes, A C Paranhos Filho, A G Oliveira
Recording the nycthemeral rhythm of sand flies allows the evaluation of the daily activity in different ecotypes, the period of greatest activity, and their degree of anthropophily. We investigated the fauna and the rhythm of sand fly activity in an ecotourism region in Mato Grosso do Sul (MS) state, Brazil. Sand flies were captured monthly, using a Shannon trap for 24 h periods between July 2012 and June 2014. We collected 1,815 sand flies, in which Lutzomyia whitmani (=Nyssomyia whitmani, sensu Galati) and Lutzomyia longipalpis were the most abundant species during the dry season, with activity from 5 p...
September 29, 2016: Journal of Medical Entomology
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