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https://www.readbyqxmd.com/read/29164809/nonsteroidal-anti-inflammatory-drugs-and-anastomotic-dehiscence-after-colorectal-surgery-a-meta-analysis
#1
REVIEW
Yeqian Huang, Stephen R Tang, Christopher J Young
BACKGROUND: Enhanced recovery after surgery protocols supports the post-operative use of nonsteroidal anti-inflammatory drugs (NSAIDs) to minimize the use of opioids. However, there is an increasing concern on the impaired wound healing of anastomosis associated with NSAID use, potentially causing a higher risk of anastomotic leakage. The aim was to conduct a meta-analysis to evaluate the association of NSAIDs with anastomotic leakage after colorectal surgery. METHODS: A literature search was conducted using the MEDLINE, PubMed, Cochrane Library and Clinicaltrial...
November 22, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29164294/a-novel-technique-of-paravertebral-thoracic-and-preperitoneal-analgesia-enhances-early-recovery-after-oesophagectomy
#2
Stephanie Phillips, Jasmina Dedic-Hagan, d'Arcy Ferris Baxter, H Van der Wall, G L Falk
BACKGROUND: Excellent analgesia following oesophagectomy facilitates patient comfort, early extubation, physiotherapy and mobilisation, reduces post-operative complications and should enhance recovery. Thoracic epidural analgesia (TEA), the gold standard analgesic regimen for this procedure, is often associated with systemic hypotension treated with inotropes or fluid. This may compromise enhanced recovery and be complicated by anastomotic ischaemia or tissue oedema. METHODS: We report a novel analgesic regimen to reduce post-operative inotrope usage...
November 21, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29163855/correction-compliance-with-the-enhanced-recovery-after-surgery-protocol-and-prognosis-after-colorectal-cancer-surgery-a-prospective-cohort-study
#3
Liang Li, Juying Jin, Su Min, Dan Liu, Ling Liu
[This corrects the article DOI: 10.18632/oncotarget.18602.].
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29161033/carbon-quantum-dots-grafted-antifouling-membranes-for-osmotic-power-generation-via-pressure-retarded-osmosis-process
#4
Die Ling Zhao, Subhabrata Das, Tai-Shung Chung
Osmotic power generated by pressure-retarded osmosis (PRO) has attracted global attention as a clean, abundant and renewable energy resource. However, the substrates of PRO membranes are particularly prone to fouling because of their direct contact with various foulants in raw water. This leads to a significant decline in power density and impedes the commercialization of PRO technology. In this work, a facile surface modification method has been developed to obtain a new type of nanoparticle functionalized antifouling PRO membranes...
November 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29160736/gat3-selective-substrate-l-isoserine-upregulates-gat3-expression-and-increases-functional-recovery-after-a-focal-ischemic-stroke-in-mice
#5
Maria Ek Lie, Emma K Gowing, Nina B Johansen, Nils Ole Dalby, Louise Thiesen, Petrine Wellendorph, Andrew N Clarkson
Ischemic stroke triggers an elevation in tonic GABA inhibition that impairs the ability of the brain to form new structural and functional cortical circuits required for recovery. This stroke-induced increase in tonic inhibition is caused by impaired GABA uptake via the glial GABA transporter GAT3, highlighting GAT3 as a novel target in stroke recovery. Using a photothrombotic stroke mouse model, we show that GAT3 protein levels are decreased in peri-infarct tissue from 6 h to 42 days post-stroke. Prior studies have shown that GAT substrates can increase GAT surface expression...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29160734/immunoparesis-and-polyclonal-immunoglobulin-recovery-after-auto-sct-for-patients-with-multiple-myeloma-treated-at-a-single-institution
#6
Victor H Jimenez-Zepeda, Peter Duggan, Paola Neri, Ahsan Chaudhry, Jason Tay, Nizar Bahlis
Immunoparesis and polyclonal immunoglobulin recovery have been recently described as common indicators of immune dysfunction in patients with multiple myeloma. In the present study, we aimed to assess the impact of immunoparesis and polyclonal immunoglobulin recovery at day-100 post autologous stem cell transplant (auto-SCT) on clinical outcomes. A total of 302 patients were included for the analysis of immunoparesis, and 197 were evaluable for polyclonal immunoglobulin recovery evaluation. Immunoparesis was observed in 93...
November 21, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29158633/comprehensive-physiological-analyses-and-reactive-oxygen-species-profiling-in-drought-tolerant-rice-genotypes-under-salinity-stress
#7
Sahana Basu, Ranjan Kumar Giri, Ibtesham Benazir, Santosh Kumar, Ravi Rajwanshi, Sharad Kumar Dwivedi, Gautam Kumar
Rice being a staple cereal is extremely susceptible towards abiotic stresses. Drought and salinity are two vital factors limiting rice cultivation in Eastern Indo-Gangetic Plains (EIGP). Present study has intended to evaluate the consequences of salinity stress on selected drought tolerant rice genotypes at the most susceptible seedling stage with an aim to identify the potential multi-stress (drought and salt) tolerant rice genotype of this region. Genotypic variation was obvious in all traits related to drought and salt susceptibility...
October 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/29157042/head-out-immersion-in-hot-water-increases-serum-bdnf-in-healthy-males
#8
Daisuke Kojima, Takeshi Nakamura, Motohiko Banno, Yasunori Umemoto, Tokio Kinoshita, Yuko Ishida, Fumihiro Tajima
PURPOSE: Brain-derived neurotrophic factor (BDNF) is an important neurotrophin. The present study investigated the effects of head-out water immersion (HOI) on serum BDNF concentrations. METHODS: Eight healthy men performed 20 min head-out water immersion at 42 °C (hot-HOI) and 35 °C (neutral-HOI). These experimental trials were administered in a randomised order separated by at least 7 days. Venous blood samples were withdrawn at rest, immediately after the 20-min HOI, as well as at 15 and 30 min after the end of the HOI...
November 20, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29155077/subchronic-oral-toxicity-study-of-korean-red-ginseng-extract-in-sprague-dawley-rats-with-a-4-week-recovery-period
#9
Sang-Jin Park, JeongHo Noh, Eun Ju Jeong, Yong-Soon Kim, Byung-Cheol Han, Seung-Ho Lee, Kyoung-Sik Moon
Ginseng is a major herbal remedy used in Asian countries for thousands of years and known to restore and enhance vital energy. Korean red ginseng, which is processed by steaming and drying fresh Panax ginseng, is most popular and contains unique ginsenosides, which have anticancer and anti-inflammatory properties. The present study was carried out to evaluate the repeated oral dose toxicity of Korean red ginseng extract. The test article was administered orally once a day to male and female Sprague-Dawley rats at dose levels of 0, 500, 1000, or 2000 mg/kg/day for 13 consecutive weeks (15 animals/sex/group in the vehicle control and 2000 mg/kg/day groups, and 10 animals/sex/group in the 500 and 1000 mg/kg/day groups)...
November 16, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29154538/enhanced-removal-of-dissolved-hg-ii-cd-ii-and-au-iii-from-water-by-bacillus-subtilis-bacterial-biomass-containing-an-elevated-concentration-of-sulfhydryl-sites
#10
Qiang Yu, Jeremy B Fein
In this study, the sorption of Hg(II), Cd(II) and Au(III) onto Bacillus subtilis biomass with an elevated concentration of sulfhydryl sites, induced by adding excess glucose to the growth medium (termed 'High Sulfhydryl Bacillus subtilis' or HSBS) was compared to that onto B. subtilis biomass with a low concentration of sulfhydryl sites (termed 'Low Sulfhydryl Bacillus subtilis' or LSBS) and to sorption onto a commercially available cation exchange resin. Our results show that HSBS exhibits sorption capacities for the three studied metals that are two to five times greater than the sorption capacities of LSBS for these metals...
November 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29154407/exercise-dynamic-stability-under-unstable-conditions-increases-muscle-strength-and-balance-ability-in-the-elderly
#11
Azza Hamed, Sebastian Bohm, Falk Mersmann, Adamantios Arampatzis
The purpose of the current study was to assess the effectiveness of a specific exercise intervention of mechanisms to control dynamic postural stability under unstable conditions in old adults. Forty-seven old adults (65-80 years) were assigned to two experimental groups (muscle strength group, n=15, perturbation-based group, n=16) and a control group (n=16). The strength group performed resistance exercises for legs and trunk muscles, while the perturbation-based group exercised mechanisms of dynamic stability under unstable conditions...
November 20, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29154003/tracing-the-role-of-endogenous-carbon-in-denitrification-using-wine-industry-by-product-as-an-external-electron-donor-coupling-isotopic-tools-with-mathematical-modeling
#12
R Carrey, P Rodríguez-Escales, A Soler, N Otero
Nitrate removal through enhanced biological denitrification (EBD), consisting of the inoculation of an external electron donor, is a feasible solution for the recovery of groundwater quality. In this context, liquid waste from wine industries (wine industry by-products, WIB) may be feasible for use as a reactant to enhance heterotrophic denitrification. To address the feasibility of WIB as electron donor to promote denitrification, as well as to evaluate the role of biomass as a secondary organic C source, a flow-through experiment was carried out...
November 16, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29152475/use-of-robotics-in-liver-donor-right-hepatectomy
#13
REVIEW
Po-Da Chen, Chao-Yin Wu, Yao-Ming Wu
Liver transplantation is the best solution for end stage liver disease, and has been widely accepted and rapidly developed in the past decades. Along with the improved outcomes of liver transplantation, living-related donor transplantation has been conducted to overcome the shortage of the deceased donor. The most important aspects of the living-related liver transplantation are donor safety and fast recovery after graft procurement. Meanwhile, the rapid progress of minimally invasive surgery (MIS) in general surgery has generated heated debate regarding the appropriateness of MIS in living-related donor graft hepatectomy...
October 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29152109/sevoflurane-preconditioning-ameliorates-traumatic-spinal-cord-injury-through-caveolin-3-dependent-cyclooxygenase-2-inhibition
#14
Weidong Wu, Ningxian Wei, Lihui Wang, Danhui Kong, Gang Shao, Yingchun Qin, Lixin Wang, Yansheng Du
Acute traumatic spinal cord injury (tSCI) results in a lifetime of paralysis associated with a host of medical complications. The developing secondary complications of tSCI may result in further chronic neurodegenerative diseases. Sevoflurane preconditioning (SF-PreCon) has shown guaranteed protective effects in myocardial or cerebral ischemic/reperfusion injury. However, the role of SF-PreCon in tSCI still remains to be elucidated. Here, we found that SF-PreCon ameliorated the developing secondary complications through reducing the apoptosis rate and the secretion of inflammatory cytokines in injured spinal cord tissues, and therefore enhancing the recovery after tSCI...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29150287/anastasis-and-the-er-stress-response-solving-the-paradox-of-the-unfolded-protein-response-in-cancer
#15
Rafael Vincent M Manalo
In recent years, studies have suggested a novel pathway for cell survival, which faces scientific skepticism and interest in its concept of cell 'resurrection' - that is, the anastasis of cells at late-stage apoptosis. While biomarkers have been discovered, many of these are related to the endoplasmic reticulum (ER) stress response - acting also to promote cell survival in the presence of perturbation. The promises of anastasis, if accepted, will greatly impact translational medicine especially in the treatment of cancer, since apoptosis is generally irreversible in the late stages, and chemotherapy is performed to maximize tumor death and minimize off-target effects...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29149855/increasing-upper-limb-training-intensity-in-chronic-stroke-using-embodied-virtual-reality-a-pilot-study
#16
Daniel Perez-Marcos, Odile Chevalley, Thomas Schmidlin, Gangadhar Garipelli, Andrea Serino, Philippe Vuadens, Tej Tadi, Olaf Blanke, José D R Millán
BACKGROUND: Technology-mediated neurorehabilitation is suggested to enhance training intensity and therefore functional gains. Here, we used a novel virtual reality (VR) system for task-specific upper extremity training after stroke. The system offers interactive exercises integrating motor priming techniques and embodied visuomotor feedback. In this pilot study, we examined (i) rehabilitation dose and training intensity, (ii) functional improvements, and (iii) safety and tolerance when exposed to intensive VR rehabilitation...
November 17, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29147450/effect-of-tirapazamine-metformin-or-mild-hyperthermia-on-recovery-from-radiation-induced-damage-in-pimonidazole-unlabeled-quiescent-tumor-cells
#17
Shin-Ichiro Masunaga, Keizo Tano, Yu Sanada, Yoshinori Sakurai, Hiroki Tanaka, Minoru Suzuki, Natsuko Kondo, Tsubasa Watanabe, Takushi Takata, Akira Maruhashi, Koji Ono
Background: The aim of the study was to examine the effect of tirapazamine (TPZ) on recovery from radiation-induced damage in pimonidazole-unlabeled quiescent (Q) tumor cells compared with that of metformin (Met) or mild temperature hyperthermia (MTH). Methods: Proliferating (P) cells in EL4 tumors were labeled by continuous 5-bromo-2'-deoxyuridine (BrdU) administration. Tumors received γ-rays at 1 h after pimonidazole administration followed by Met or TPZ treatment or MTH...
October 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29143997/epidermal-neural-crest-stem-cell-derived-glia-enhance-neurotrophic-elements-in-an-ex-vivo-model-of-spinal-cord-injury
#18
Sareh Pandamooz, Mohammad Saied Salehi, Mohammad Ismail Zibaii, Abolhassan Ahmadiani, Mohammad Nabiuni, Leila Dargahi
Growing evidence that cell-based therapies can improve recovery outcome in spinal cord injury (SCI) models substantiates their application for treatment of human with SCI. To address the effectiveness of these stem cells, potential candidates should be evaluated in proper SCI platform that allows direct real-time monitoring. In this study, the role of epidermal neural crest stem cells (EPI-NCSCs) was elucidated in an ex vivo model of SCI and valproic acid (VPA) was administered to ameliorate the inhospitable context of injury for grafted EPI-NCSCs...
November 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29143704/identification-of-clostridium-difficile-reservoirs-in-the-patient-environment-and-efficacy-of-aerial-hydrogen-peroxide-decontamination
#19
Samuel Yui, Shanom Ali, Monika Muzslay, Annette Jeanes, A Peter R Wilson
OBJECTIVE To identify, using a novel enhanced method of recovery, environmental sites where spores of Clostridium difficile persist despite cleaning and hydrogen peroxide aerial decontamination. DESIGN Cohort study. SETTING Tertiary referral center teaching hospital. METHODS In total, 16 sites representing high-frequency contact or difficult-to-clean surfaces in a single-isolation room or bed area in patient bed bays were sampled before and after terminal or hydrogen peroxide disinfection using a sponge swab...
November 16, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29140901/-state-of-the-art-techniques-in-treating-peripheral-nerve-injury
#20
Carrie A Kubiak, Theodore A Kung, David L Brown, Paul S Cederna, Stephen W P Kemp
BACKGROUND -: Peripheral nerve injuries remain a major clinical concern as they often lead to chronic disability and significant health care expenditures. Despite advancements in microsurgical techniques to enhance nerve repair, biologic approaches are needed to augment nerve regeneration and improve functional outcomes after injury. METHODS -: Presented herein is a review of the current literature on state of the art techniques to enhance functional recovery for patients with nerve injury...
November 11, 2017: Plastic and Reconstructive Surgery
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