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https://www.readbyqxmd.com/read/28934532/preemptive-caffeine-administration-blocks-the-increase-in-postoperative-pain-caused-by-previous-sleep-loss-in-the-rat-a-potential-role-for-preoptic-adenosine-a2a-receptors-in-sleep-pain-interactions
#1
Viviane S Hambrecht-Wiedbusch, Maya Gabel, Linda J Liu, John P Imperial, Angelo V Colmenero, Giancarlo Vanini
Sleep and pain are reciprocally related, but the precise mechanisms underlying this relationship are poorly understood. This study used a rat model of surgical pain to examine the effect of previous sleep loss on postoperative pain and tested the hypothesis that preoptic adenosinergic mechanisms regulate sleep-pain interactions. Relative to ad libitum sleep, 6 hours of total sleep deprivation prior to a surgical incision significantly enhanced postoperative mechanical hypersensitivity in the affected paw and prolonged the time to recovery from surgery...
September 1, 2017: Sleep
https://www.readbyqxmd.com/read/28934227/hemorrhage-enhances-cytokine-complement-component-3-and-caspase-3-and-regulates-micrornas-associated-with-intestinal-damage-after-whole-body-gamma-irradiation-in-combined-injury
#2
Juliann G Kiang, Joan T Smith, Marsha N Anderson, Thomas B Elliott, Paridhi Gupta, Nagaraja S Balakathiresan, Radha K Maheshwari, Barbara Knollmann-Ritschel
Hemorrhage following whole-body γ-irradiation in a combined injury (CI) model increases mortality compared to whole-body γ-irradiation alone (RI). The decreased survival in CI is accompanied by increased bone marrow injury, decreased hematocrit, and alterations of miRNA in the kidney. In this study, our aim was to examine cytokine homeostasis, susceptibility to systemic bacterial infection, and intestinal injury. More specifically, we evaluated the interleukin-6 (IL-6)-induced stress proteins including C-reactive protein (CRP), complement 3 (C3), Flt-3 ligand, and corticosterone...
2017: PloS One
https://www.readbyqxmd.com/read/28933219/suppression-of-trim32-enhances-motor-function-repair-after-traumatic-brain-injury-associated-with-antiapoptosis
#3
Zi-Bin Zhang, Liu-Lin Xiong, Bin-Tuan Lu, Hui-Xiang Zhang, Piao Zhang, Ting-Hua Wang
To investigate the role of Trim32 in traumatic brain injury (TBI), adult male Sprague Dawley (SD) rats and mice were randomly divided into sham (n = 6) and TBI groups ( n = 24), respectively. Then, mice were assigned into Trim32 knockout mice (Trim32-KO [+/-]) and wild-type (WT) littermates. The TBI model used was the Feeney free-falling model, and neurological function was evaluated after TBI using a neurological severity score (NSS). Reverse transcription polymerase chain reaction (RT-PCR), Western blot, and immunohistochemistry were used to investigate the expression of Trim32 in the damaged cortex...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28933217/implantation-of-brain-derived-extracellular-matrix-enhances-neurological-recovery-after-traumatic-brain-injury
#4
Yun Wu, Jiayin Wang, Yejie Shi, Hongjian Pu, Rehana K Leak, Anthony K F Liou, Stephen F Badylak, Zhixiong Liu, Jun Zhang, Jun Chen, Ling Chen
Scaffolds composed of extracellular matrix (ECM) are being investigated for their ability to facilitate brain tissue remodeling and repair following injury. The present study tested the hypothesis that the implantation of brain-derived ECM would attenuate experimental traumatic brain injury (TBI) and explored potential underlying mechanisms. TBI was induced in mice by a controlled cortical impact (CCI). ECM was isolated from normal porcine brain tissue by decellularization methods, prepared as a hydrogel, and injected into the ipsilesional corpus callosum and striatum 1 h after CCI...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28932946/ready-to-go-home-patients-experiences-of-the-discharge-process-in-an-enhanced-recovery-after-surgery-eras-program-for-colorectal-surgery
#5
D Jones, R Musselman, E Pearsall, M McKenzie, H Huang, Robin S McLeod
BACKGROUND: With the adoption of enhanced recovery after surgery (ERAS) programs, patients are being discharged earlier and require more post-discharge teaching, educational materials, and information. OBJECTIVE: The purpose of this study is to assess satisfaction, discharge needs, and follow-up concerns of patients within an ERAS implementation program (iERAS). METHODS: Between 2012 and 2015, the iERAS program was undertaken at an academic hospital where 554 patients having elective colorectal surgery were enrolled...
September 20, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28932752/local-rhbmp-12-on-an-absorbable-collagen-sponge-as-an-adjuvant-therapy-for-rotator-cuff-repair-a-phase-1-randomized-standard-of-care-control-multicenter-study-part-2-a-pilot-study-of-functional-recovery-and-structural-outcomes
#6
Junji Ide, Yu Mochizuki, Arthur van Noort, Hiroshi Ochi, Sudhakar Sridharan, Eiji Itoi, Stefan Greiner
BACKGROUND: The high failure rate of rotator cuff repairs requires the development of methods to enhance healing at the tendon-bone junction of the repair site. PURPOSE: To assess functional recovery and structural outcomes in detail after implanting recombinant human bone morphogenetic protein-12 (rhBMP-12)/absorbable collagen sponge (ACS) as adjuvant treatment during open rotator cuff repair in patients over a 1-year postoperative follow-up. STUDY DESIGN: Randomized controlled trial; Level of evidence, 2...
September 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28932127/an-in-vitro-model-of-renal-inflammation-after-ischemic-oxidative-stress-injury-nephroprotective-effects-of-a-hyaluronan-ester-with-butyric-acid-on-mesangial-cells
#7
Olga Baraldi, Francesca Bianchi, Viola Menghi, Andrea Angeletti, Anna Laura Croci Chiocchini, Maria Cappuccilli, Valeria Aiello, Giorgia Comai, Gaetano La Manna
BACKGROUND: Acute kidney injury, known as a major trigger for organ fibrosis and independent predictor of chronic kidney disease, is characterized by mesangial cell proliferation, inflammation and unbalance between biosynthesis and degradation of extracellular matrix. Therapeutic approaches targeting the inhibition of mesangial cell proliferation and matrix expansion may represent a promising opportunity for the treatment of kidney injury. An ester of hyaluronic acid and butyric acid (HB) has shown vasculogenic and regenerative properties in renal ischemic-damaged tissues, resulting in enhanced function recovery and minor degree of inflammation in vivo...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/28931811/distal-axotomy-enhances-retrograde-presynaptic-excitability-onto-injured-pyramidal-neurons-via-trans-synaptic-signaling
#8
Tharkika Nagendran, Rylan S Larsen, Rebecca L Bigler, Shawn B Frost, Benjamin D Philpot, Randolph J Nudo, Anne Marion Taylor
Injury of CNS nerve tracts remodels circuitry through dendritic spine loss and hyper-excitability, thus influencing recovery. Due to the complexity of the CNS, a mechanistic understanding of injury-induced synaptic remodeling remains unclear. Using microfluidic chambers to separate and injure distal axons, we show that axotomy causes retrograde dendritic spine loss at directly injured pyramidal neurons followed by retrograde presynaptic hyper-excitability. These remodeling events require activity at the site of injury, axon-to-soma signaling, and transcription...
September 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28931573/chd7-collaborates-with-sox2-to-regulate-activation-of-oligodendrocyte-precursor-cells-after-spinal-cord-injury
#9
Toru Doi, Toru Ogata, Junji Yamauchi, Yasuhiro Sawada, Sakae Tanaka, Motoshi Nagao
Oligodendrocyte precursor cells (OPCs) act as a reservoir of new oligodendrocytes (OLs) in homeostatic and pathological conditions. OPCs are activated in response to injury, to generate myelinating OLs; however, the underlying mechanisms remain poorly understood. Here we show that Chd7 regulates OPC activation after spinal cord injury (SCI). Chd7 is expressed in OPCs in the adult spinal cord and its expression is upregulated with a concomitant increase in Sox2 expression following SCI. OPC-specific ablation of Chd7 in the injured mice leads to reduced OPC proliferation, the loss of OPC identity, and impaired OPC differentiation...
September 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28930840/enhanced-recovery-program-versus-traditional-care-after-hepatectomy-a-meta-analysis
#10
Le Li, Jinming Chen, Zhonghua Liu, Qiang Li, Ying Shi
To assess the safety and efficacy of enhanced recovery after surgery (ERAS) as compared with the traditional care in patients undergoing liver surgery and optimization of enhanced recovery programs.Literature, until August 2016, was searched to identify the comparative studies evaluating preoperative hospital stay time, complications, and C-reactive protein (CRP). Pooled odds ratios (OR) or weighted mean differences (WMDs) were calculated with either the fixed or random effect model.These studies included a total of 524 patients: 254 treated with ERAS and 270 with traditional care...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930755/vegf-and-igf-delivered-from-alginate-hydrogels-promote-stable-perfusion-recovery-in-ischemic-hind-limbs-of-aged-mice-and-young-rabbits
#11
Erin M Anderson, Eduardo A Silva, Yibai Hao, Kathleen D Martinick, Sarah A Vermillion, Alexander G Stafford, Elisabeth G Doherty, Lin Wang, Edward J Doherty, Paul M Grossman, David J Mooney
Biomaterial-based delivery of angiogenic growth factors restores perfusion more effectively than bolus delivery methods in rodent models of peripheral vascular disease, but the same success has not yet been demonstrated in clinically relevant studies of aged or large animals. These studies explore, in clinically relevant models, a therapeutic angiogenesis strategy for the treatment of peripheral vascular disease that overcomes the challenges encountered in previous clinical trials. Alginate hydrogels providing sustained release of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF) were injected into ischemic hind limbs in middle-aged and old mice, and also in young rabbits, as a test of the scalability of this local growth factor treatment...
September 21, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28927808/disentangling-the-climate-driven-bimodal-growth-pattern-in-coastal-and-continental-mediterranean-pine-stands
#12
Arturo Pacheco, J Julio Camarero, Montse Ribas, Antonio Gazol, E Gutierrez, Marco Carrer
Mediterranean climate promotes two distinct growth peaks separated by summer quiescence in trees. This bimodal pattern has been associated to favourable growing conditions during spring and autumn when mild temperatures and soil-water availability enhance cambial activity. Climatic models predict progressive warming and drying for the Mediterranean Basin, which could shorten or shift the spring and autumn growing seasons. We explored this idea by comparing two sites with different Mediterranean climate types (continental/dry and coastal/wet) and studied how climate drives the bimodal growth pattern in Aleppo pine (Pinus halepensis)...
September 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28926907/research-on-the-quick-and-efficient-recovery-of-1-allyl-3-methylimidazolium-chloride-after-biomass-pretreatment-with-ionic-liquid-aqueous-alcohol-system
#13
Xiaocong Liang, Yan Fu, Jie Chang
Membrane-based methodology electrodialysis (ED) was employed for the quick and efficient recovery of ionic liquid AmimCl from the aqueous solutions after biomass pretreatment with AmimCl-aqueous methanol/ethanol systems. IL recovery performance was relatively stable as the variation of IL-alcohol systems employed in the pretreatment process. IL recovery ratio (R) of 66%-71%, IL recovery performance of specific energy consumption (Sp) of 429-467g/kwh and IL transport rate (Tr) of 5.3-8.2g/(m(2)min) were obtained by single ED treatment...
August 24, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28922963/lentivirus-mediating-fgf13-enhances-axon-regeneration-after-spinal-cord-injury-by-stablilizing-microtubule-and-improving-mitochondrial-function
#14
Jiawei Li, Qingqing Wang, Haoli Wang, Yanqing Wu, Jiayu Yin, Jian Chen, Zengming Zheng, Ting Jiang, Ling Xie, Fenzan Wu, Hongyu Zhang, Xiaokun Li, Huazi Xu, Jian Xiao
Fibroblast growth factor 13 (FGF13), a nonsecretory protein of the FGF family, plays a crucial role in developing cortical neurons by stabilizing the microtubule. In previous studies, we showed that regulation of microtubule dynamic was instrumental for both growth cone initiation and for promoting regrowth of injured axon. However, the expression and effect of FGF13 in spinal cord or after spinal cord injury (SCI) remains undefined. Here, we demonstrated a role of FGF13 in regulating microtubule dynamics and in enhancing axon regeneration after SCI...
September 19, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28922216/opioid-free-analgesia-in-the-era-of-enhanced-recovery-after-surgery-and-the-surgical-home-implications-for-postoperative-outcomes-and-population-health
#15
Nirav V Kamdar, Nir Hoftman, Siamak Rahman, Maxime Cannesson
No abstract text is available yet for this article.
October 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28921765/assessing-fire-impacts-on-the-carbon-stability-of-fire-tolerant-forests
#16
Lauren T Bennett, Matthew J Bruce, Josephine Machunter, Michele Kohout, Saravanan Jangammanaidu Krishnaraj, Cristina Aponte
The carbon stability of fire-tolerant forests is often assumed but less frequently assessed, limiting potential to anticipate threats to forest carbon posed by predicted increases in forest fire activity. Assessing the carbon stability of fire-tolerant forests requires multi-indicator approaches that recognise the myriad of ways that fires influence the carbon balance including combustion, deposition of pyrogenic material, and tree death, post-fire decomposition, recruitment, and growth. Five years after a large-scale wildfire in south-eastern Australia, we assessed the impacts of low- and high-severity wildfire, with and without prescribed fire (≤ 10 years before), on carbon stocks in multiple pools, and on carbon stability indicators (carbon stock percentages in live trees and in small trees, and carbon stocks in char and fuels) in fire-tolerant eucalypt forests...
September 16, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28921632/elevated-solute-transport-at-sites-of-diffuse-matrix-damage-in-cortical-bone-implications-on-bone-repair
#17
Bin Wang, Xuanhao Sun, Ozan Akkus, Liyun Wang
Diffuse matrix damage in rat cortical bone has been observed to self-repair efficiently in two weeks without activating bone remodeling, and unlike the case with linear cracks, the local osteocytes at the sites of diffuse damage remain healthy. However, the reason(s) for such high efficiency of matrix repair remains unclear. We hypothesized that transport of minerals and other compounds essential for damage repair is enhanced at the damaged sites and further increased by the application of tensile loading. To test our hypothesis, diffuse damage was introduced in notched bovine wafers under cyclic tensile loading and unloading...
September 16, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28920046/the-effect-of-intraoperative-alkali-treatment-on-recovery-from-atracurium-induced-neuromuscular-blockade-in-renal-transplantation-a-randomized-trial
#18
Navid Noraee, Mohammad Fathi, Majid Golestani Eraghi, Ali Dabbagh, Nilofar Massoudi
BACKGROUND: Intraoperative care and anesthesia method in patients undergoing allograft renal transplantation surgery are very necessary. Acid-base imbalance can alter neuromuscular blockade and recovery time. OBJECTIVES: The aim of the present study was to investigate the effect of acid-base balance on atracurium blockade in renal transplantation. METHODS: In this randomized-controlled trial, 31 end-stage renal disease (ESRD) patients undergoing renal transplantation were randomly assigned into two equal groups...
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28916971/emergency-room-visits-and-readmissions-following-implementation-of-an-enhanced-recovery-after-surgery-ieras-program
#19
Trevor Wood, Mary-Anne Aarts, Allan Okrainec, Emily Pearsall, J Charles Victor, Marg McKenzie, Ori Rotstein, Robin S McLeod
BACKGROUND: Enhanced Recovery After Surgery (ERAS) guidelines have been widely promoted and supported largely due to several studies showing decreased post-operative complications and length of stay. The objective of this study was to review the emergency room (ER) visits and readmission rates and reasons for both in patients who were part of the Implementation of an Enhanced Recovery After Surgery (iERAS) program for colorectal surgery. METHODS: All patients having elective colorectal surgery at 15 academic hospitals were enrolled in the iERAS program...
September 15, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28916861/predictors-of-adherence-to-enhanced-recovery-pathway-elements-after-laparoscopic-colorectal-surgery
#20
Juan Mata, Julio F Fiore, Nicolo Pecorelli, Barry L Stein, Sender Liberman, Patrick Charlebois, Liane S Feldman
INTRODUCTION: Enhanced recovery pathways (ERP) include a bundle of evidence-based preoperative, intraoperative, and postoperative interventions that together reduce morbidity and length of stay after colorectal surgery. Increased adherence with the bundle is associated with better postoperative outcomes, but adherence is lowest in the postoperative period. Identifying risk factors for lower adherence may help design quality improvement strategies. The aim of this study was to estimate the extent to which patient, procedural, and organizational factors predict adherence to postoperative ERP elements in laparoscopic colorectal surgery...
September 15, 2017: Surgical Endoscopy
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