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Schizoaffective disorder

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https://www.readbyqxmd.com/read/28716789/identification-of-the-delivery-of-cognitive-behavioural-therapy-for-psychosis-cbtp-using-a-cross-sectional-sample-from-electronic-health-records-and-open-text-information-in-a-large-uk-based-mental-health-case-register
#1
Craig Colling, Lauren Evans, Matthew Broadbent, David Chandran, Thomas J Craig, Anna Kolliakou, Robert Stewart, Philippa A Garety
OBJECTIVE: Our primary objective was to identify cognitive behavioural therapy (CBT) delivery for people with psychosis (CBTp) using an automated method in a large electronic health record database. We also examined what proportion of service users with a diagnosis of psychosis were recorded as having received CBTp within their episode of care during defined time periods provided by early intervention or promoting recovery community services for people with psychosis, compared with published audits and whether demographic characteristics differentially predicted the receipt of CBTp...
July 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28712353/cost-effectiveness-of-a-ptsd-intervention-tailored-for-individuals-with-severe-mental-illness
#2
Eric P Slade, Jennifer D Gottlieb, Weili Lu, Philip T Yanos, Stanley Rosenberg, Steven M Silverstein, Shula K Minsky, Kim T Mueser
OBJECTIVE: This study examined the cost-effectiveness of a cognitive-behavioral therapy (CBT) intervention for posttraumatic stress disorder (PTSD) that is tailored for adults with a co-occurring severe mental illness. METHODS: Data were from a randomized trial involving 183 adult clients of two outpatient clinics and three partial hospitalization programs. All had a severe mental illness diagnosis (major mood disorder, schizophrenia, or schizoaffective disorder) and severe PTSD...
July 17, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28709771/gesture-impairments-in-schizophrenia-are-linked-to-increased-movement-and-prolonged-motor-planning-and-execution
#3
Lars Levi Dutschke, Katharina Stegmayer, Fabian Ramseyer, Stephan Bohlhalter, Tim Vanbellingen, Werner Strik, Sebastian Walther
Schizophrenia patients present with a variety of impaired nonverbal communication skills. Performance of hand gestures is frequently impaired and associated with ratings of motor abnormalities. However, the impact of motor abnormalities to gesture performance remains unclear. To test the association between quantitative measures of motor behavior and qualitative ratings of gesture performance, we quantified movement parameters semi-automatically in videotaped recordings of gesture assessment. Thirty-one patients with schizophrenia (77...
July 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28688282/social-cognition-interventions-for-people-with-schizophrenia-a-systematic-review-focussing-on-methodological-quality-and-intervention-modality
#4
REVIEW
Nina Grant, Megan Lawrence, Antonio Preti, Til Wykes, Matteo Cella
BACKGROUND: People with a diagnosis of schizophrenia have significant social and functional difficulties. Social cognition was found to influences these outcomes and in recent years interventions targeting this domain were developed. This paper reviews the existing literature on social cognition interventions for people with a diagnosis of schizophrenia focussing on: i) comparing focussed (i.e. targeting only one social cognitive domain) and global interventions and ii) studies methodological quality...
June 23, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28687481/prevalence-and-risk-factors-for-hiv-hepatitis-b-and-hepatitis-c-in-people-with-severe-mental-illness-a-total-population-study-of-sweden
#5
Clarissa Bauer-Staeb, Lena Jörgensen, Glyn Lewis, Christina Dalman, David P J Osborn, Joseph F Hayes
BACKGROUND: Severe mental illness is associated with increased morbidity and mortality. The elevated risk of blood-borne viruses (BBVs) in people with severe mental illness is of concern, but the full extent of this problem is unclear. We aimed to determine the prevalence of and risk factors for BBVs in people with severe mental illness. METHODS: In this nationwide, population-based, cross-sectional study, we estimated the point prevalence of HIV, hepatitis B (HBV), and hepatitis C (HCV) in people with severe mental illness, including the total adult (≥18 years) Swedish population...
July 4, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28675307/pharmacokinetic-drug-evaluation-of-paliperidone-in-the-treatment-of-schizoaffective-disorder
#6
Matthew Macaluso, Hannah Oliver, Zohaib Sohail
This paper reviews the pharmacokinetics, receptor binding, clinical efficacy and safety of paliperidone in the treatment of patients with schizoaffective disorder. Areas Covered: We reviewed the literature using keywords "paliperidone", "schizoaffective disorder" and "clinical trials" with a focus on seminal data papers and information that is clinically relevant to the treatment of schizoaffective disorder. The purpose of this paper is to provide a clinically oriented review of the pharmacokinetic and pharmacodynamic properties of paliperidone including receptor binding, clinical efficacy, safety and tolerability...
July 4, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28674504/antigliadin-antibodies-aga-igg-are-related-to-neurochemistry-in-schizophrenia
#7
Laura M Rowland, Haley K Demyanovich, S Andrea Wijtenburg, William W Eaton, Katrina Rodriguez, Frank Gaston, Daniela Cihakova, Monica V Talor, Fang Liu, Robert R McMahon, L Elliot Hong, Deanna L Kelly
Inflammation may play a role in schizophrenia; however, subgroups with immune regulation dysfunction may serve as distinct illness phenotypes with potential different treatment and prevention strategies. Emerging data show that about 30% of people with schizophrenia have elevated antigliadin antibodies of the IgG type, representing a possible subgroup of schizophrenia patients with immune involvement. Also, recent data have shown a high correlation of IgG-mediated antibodies between the periphery and cerebral spinal fluid in schizophrenia but not healthy controls, particularly AGA IgG suggesting that these antibodies may be crossing the blood-brain barrier with resulting neuroinflammation...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28673755/psychomotor-assessment-as-a-tool-to-differentiate-schizophrenia-from-other-psychotic-disorders
#8
S Janssens, H Moens, V Coppens, F Vandendriessche, W Hulstijn, B Sabbe, M Morrens
GOAL: The aim of this study is to assess to what extent psychomotor assessment can aid the clinician in differentiating between schizophrenia and other psychotic disorders. METHODS: Enrolled subjects were recent in remission patients (n=304), who all met DSM-IV (APA, 2013) criteria for either schizophrenia (Sz; n=117), schizoaffective disorder (SaD; n=36), psychotic disorder not otherwise specified (P-NOS) (n=86), substance/medication-induced psychotic disorder (SIPD; n=33) or major depressive disorder with psychotic features (MDD-p; n=32)...
June 30, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28673279/pharmacogenetic-evaluation-to-assess-breakthrough-psychosis-with-aripiprazole-long-acting-injection-a-case-report
#9
Seenae Eum, Mark E Schneiderhan, Jacob T Brown, Adam M Lee, Jeffrey R Bishop
BACKGROUND: Given the complex nature of symptom presentation and medication regimens, psychiatric clinics may benefit from additional tools to personalize treatments. Utilizing pharmacogenetic information may be helpful in assessing unique responses to therapy. We report herein a case of wearing-off phenomena during treatment with aripiprazole long-acting injectable (LAI) and a proof of concept strategy of how pharmacogenetic information may be used to assess possible genetic factors and also hypothesize potential mechanisms for further study...
July 3, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28668716/replication-of-rs300774-a-genetic-biomarker-near-acp1-associated-with-suicide-attempts-in-patients-with-schizophrenia-relation-to-brain-cholesterol-biosynthesis
#10
Jiang Li, Akane Yoshikawa, Herbert Y Meltzer
The aim of this study was to determine if three biomarkers for suicide attempts previously identified and replicated in a genome-wide association (GWAS) study of bipolar disorder (BD) suicide attempters also predicted suicide attempts in patients prospectively diagnosed with schizophrenia (SCZ) or schizoaffective disorder (SAD). 162 genetically-verified Caucasian patients with SCZ or SAD were phenotyped for presence (45.7%) or absence of a lifetime suicide attempt. Three single nucleotide polymorphisms (SNPs) were genotyped or partially imputed from a GWAS dataset...
June 16, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28658489/association-of-electroconvulsive-therapy-with-psychiatric-readmissions-in-us-hospitals
#11
Eric P Slade, Danielle R Jahn, William T Regenold, Brady G Case
Importance: Although electroconvulsive therapy (ECT) is considered the most efficacious treatment available for individuals with severe affective disorders, ECT's availability is limited and declining, suggesting that information about the population-level effects of ECT is needed. Objective: To examine whether inpatient treatment with ECT is associated with a reduction in 30-day psychiatric readmission risk in a large, multistate sample of inpatients with severe affective disorders...
June 28, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28655480/associations-of-suicidality-with-cognitive-ability-and-cognitive-insight-in-outpatients-with-schizophrenia
#12
Jennifer Villa, Jennifer Choi, Julie L Kangas, Christopher N Kaufmann, Philip D Harvey, Colin A Depp
BACKGROUND: Previous literature suggests that better cognitive ability and insight are associated with greater lifetime risk of suicide attempts in schizophrenia, counter to the direction of association in the general population. However, the conjoint association between distinct cognitive domains, insight, and suicidality has not been assessed. METHOD: In a cross-sectional study, 162 adults with schizophrenia or schizoaffective disorder completed cognitive testing via the MATRICS battery, symptom and cognitive insight assessments, along with the Columbia Suicide Severity Rating Scale...
June 24, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28645961/cognitive-screening-and-behavioural-observation-of-functional-ability-in-patients-with-multiple-episode-schizophrenia-an-exploratory-study
#13
Eva Norlin Bagge, Eva Esbjörnsson, Katharina S Sunnerhagen
OBJECTIVES: To evaluate the usability of a neuropsychological screening instrument and two observation scales of everyday behaviour to describe cognitive and functional capacity of patients with multiepisode schizophrenia and considerable care needs, who frequently refuse to participate in cognitive testing or performance-based functional measurement. SETTING: One psychiatric unit specialised in severe mental illness at the Sahlgrenska University Hospital, Gothenburg, Sweden...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645056/serious-delinquency-and-later-schizophrenia-a-nationwide-register-based-follow-up-study-of-finnish-pretrial-15-to-19-year-old-offenders-sent-for-a-forensic-psychiatric-examination
#14
N Lindberg, J Miettunen, A Heiskala, R Kaltiala-Heino
BACKGROUND: Aggressive and disruptive behaviors often precede the onset of schizophrenia. In this register-based follow-up study with a case-control design, we wanted to investigate if serious delinquency was associated with future diagnoses of schizophrenia or schizoaffective disorder (here, broadly defined schizophrenia) among a nationwide consecutive sample of 15- to 19-year-old Finnish delinquents sent for a forensic psychiatric examination in 1989-2010. METHODS: The sample comprised 313 delinquents with no past or current psychotic disorder...
May 15, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28634529/duodenal-diverticulum-incidental-finding-with-potentially-dangerous-outcomes
#15
Stephen Melnick, Shoaib Fareedy, David Gish, Salik Nazir
We present the case of an 83-year-old woman with a past medical history significant for schizoaffective disorder, presenting to our emergency department with the complaint of 'pain'. Given the non-specific complaint and the limited history obtained, CT imaging was performed on her chest and abdomen which incidentally found a large duodenal diverticulum. This manuscript discusses the incidence of duodenal diverticula and the potential associated complications.
January 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28628109/truncating-mutations-in-rbm12-are-associated-with-psychosis
#16
Stacy Steinberg, Steinunn Gudmundsdottir, Gardar Sveinbjornsson, Jaana Suvisaari, Tiina Paunio, Minna Torniainen-Holm, Michael L Frigge, Gudrun A Jonsdottir, Johanna Huttenlocher, Sunna Arnarsdottir, Oddur Ingimarsson, Magnus Haraldsson, Thorarinn Tyrfingsson, Thorgeir E Thorgeirsson, Augustine Kong, Gudmundur L Norddahl, Daniel F Gudbjartsson, Engilbert Sigurdsson, Hreinn Stefansson, Kari Stefansson
Thus far, a handful of highly penetrant mutations conferring risk of psychosis have been discovered. Here we used whole-genome sequencing and long-range phasing to investigate an Icelandic kindred containing ten individuals with psychosis (schizophrenia, schizoaffective disorder or psychotic bipolar disorder). We found that all affected individuals carry RBM12 (RNA-binding-motif protein 12) c.2377G>T (P = 2.2 × 10(-4)), a nonsense mutation that results in the production of a truncated protein lacking a predicted RNA-recognition motif...
June 19, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28627459/peripheral-blood-gene-expression-of-acute-phase-proteins-in-people-with-first-episode-psychosis
#17
Jie Yin Yee, Milawaty Nurjono, Wai Yee Ng, Stephanie Ruth Teo, Tih-Shih Lee, Jimmy Lee
BACKGROUND: There is a growing interest in the association between schizophrenia and the activation of inflammatory system with signs of acute phase (AP) response. Majority of such studies had focused on C-reactive protein (CRP). The aims of the present study were (i) to examine the gene expression profiles of other acute phase proteins (APP), namely haptoglobin (HP), alpha-1 antitrypsin (A1T), and alpha-2 macroglobulin (A2M) in patients with first episode psychosis (FEP) over a period of three months and (ii) to explore the association between APP levels and severity of symptoms...
June 13, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28626271/long-acting-injectable-paliperidone-palmitate-a-review-of-efficacy-and-safety
#18
Matthew T Morris, Sandip P Tarpada
OBJECTIVE: Summarize and synthesize the current literature regarding long-acting injectable paliperidone palmitate for the treatment of schizophrenia. METHODS: A literature search of PubMed, Embase, and Web of Science was conducted in February 2016, using the following search terms in varying permutations: schizophrenia; antipsychotic medication; long-acting injectable; paliperidone palmitate; 3-monthly injectable. RESULTS: Once-monthly injectable paliperidone palmitate (PDP) has demonstrated comparable efficacy as 1st-generation long-acting injectable antipsychotics (LAIAs) in reducing disease severity and re-hospitalizations in schizophrenic patients...
May 15, 2017: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/28622159/weeding-out-the-justification-for-marijuana-treatment-in-patients-with-developmental-and-behavioral-conditions
#19
Theodora Nelson, Yi Hui Liu, Kara S Bagot, Martin T Stein
Alex is a 13-year-old adolescent with high-functioning autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD)-combined type, anxiety, and depression. He has been resistant to engaging in therapy and treatment with various medications has been unsuccessful. Alex's parents are concerned about his anxiety, isolation, oppositional behaviors, academic underachievement, truancy, and substance use. A recent altercation with his stepfather led to a police intervention and a brief removal of Alex from the home...
July 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28615119/schizophrenia-and-induced-abortions-a-national-register-based-follow-up-study-among-finnish-women-born-between-1965-1980-with-schizophrenia-or-schizoaffective-disorder
#20
Laura Simoila, Erkki Isometsä, Mika Gissler, Jaana Suvisaari, Eila Sailas, Erja Halmesmäki, Nina Lindberg
BACKGROUND: The objectives of this study were to investigate, in women with schizophrenia or schizoaffective disorder, the number and incidence of induced abortions (= pregnancy terminations performed by a physician), their demographic characteristics, use of contraceptives, plus indications of and complications related to pregnancy termination. METHODS: Using the Care Register for Health Care, we identified Finnish women born between the years 1965-1980 who were diagnosed with either schizophrenia or schizoaffective disorder during the follow-up period ending 31...
June 11, 2017: Schizophrenia Research
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