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Schizoaffective disorder

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https://www.readbyqxmd.com/read/29141124/the-effects-of-valbenazine-in-participants-with-tardive-dyskinesia-results-of-the-1-year-kinect-3-extension-study
#1
Stewart A Factor, Gary Remington, Cynthia L Comella, Christoph U Correll, Joshua Burke, Roland Jimenez, Grace S Liang, Christopher F O'Brien
BACKGROUND: Valbenazine, a highly selective vesicular monoamine transporter 2 inhibitor, is approved for the treatment of tardive dyskinesia. This is the first report of long-term effects in adults with tardive dyskinesia. METHODS: Participants with a DSM-IV diagnosis of schizophrenia, schizoaffective disorder, or a mood disorder who completed the 6-week, double-blind, placebo-controlled period of KINECT 3 were eligible to enter the 42-week valbenazine extension (VE) period and subsequent 4-week washout period...
November 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29128304/symptoms-of-mental-illness-and-their-impact-on-managing-type-2-diabetes-in-adults
#2
Adriana Cimo, Carolyn S Dewa
OBJECTIVES: People with mental illnesses are more likely to experience diabetes-related complications that can reduce life expectancy by 10 to 15 years. Diabetes management and outcomes can be improved when lifestyle interventions addressing healthful eating habits and physical activity use content tailored to the learning needs of individuals or groups. Understanding the challenges that prevent adherence to diabetes recommendations can start to inform the design of tailored diabetes education care...
November 8, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29125018/the-glasgow-antipsychotic-side-effects-scale-for-clozapine-in-inpatients-and-outpatients-with-schizophrenia-or-schizoaffective-disorder
#3
Dragana Ignjatović Ristić, Dan Cohen, Andrea Obradović, Katarina Nikić-Đuričić, Marija Drašković, Darko Hinić
BACKGROUND: The inconsistency in clinician and patient ratings of clozapine-induced side effects underscore the need to supplement clinician-based estimates of side effects with patient-reported ones. AIMS: The main aims of the study are validation of the Glasgow antipsychotic side-effects scale for clozapine (GASS-C) in Serbian inpatients/outpatients with schizophrenia or schizo-affective disorder and recommendations for its future use, based on common and rare clozapine-associated side-effects...
November 10, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29124951/the-role-of-serious-mental-illness-in-motivation-participation-and-adoption-of-health-behavior-change-among-obese-sedentary-latino-adults
#4
Daniel E Jimenez, Lauren Thomas, Stephen J Bartels
OBJECTIVE: Serious mental illness (SMI; e.g. schizophrenia, schizoaffective disorder, delusional disorder, bipolar disorder, severe major depressive disorder, and psychotic disorders) and Latino ethnicity can produce a compounded health disparity, placing individuals at particularly high risk for excess morbidity and premature mortality. In this study we sought to identify the role of SMI in motivation, participation, and adoption of health behavior change among overweight Latino adults...
November 10, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/29120842/do-cognitive-deficits-predict-negative-emotionality-and-aggression-in-schizophrenia
#5
Anthony O Ahmed, Jenae Richardson, Alex Buckner, Sabrina Romanoff, Michelle Feder, Njideka Oragunye, Andriana Ilnicki, Ishrat Bhat, Matthew J Hoptman, Jean-Pierre Lindenmayer
Schizophrenia is associated with an elevated risk of aggression. Cognitive deficits have been associated with inpatient aggression and future violence. The relationship between cognitive deficits and violent behavior has however been inconsistent across studies. In addition, studies have failed to inform how cognitive deficits may contribute to aggression in schizophrenia. The current study examined the association of cognitive deficits with schizophrenia-related aggression and violent offending. It also explored the putative mediating role of negative emotionality on the impact of cognitive deficits on aggression...
November 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29117025/heads-up-the-presentation-of-schizoaffective-disorder-in-an-elite-college-soccer-player-with-prior-concussion
#6
Solomon J Adelsky, Simon Ducharme, Emily K Wilner, Benjamin Yudkoff, Simon Lejeune
No abstract text is available yet for this article.
November 2017: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/29107449/risk-of-gastrointestinal-hypomotility-in-schizophrenia-and-schizoaffective-disorder-treated-with-antipsychotics-a-retrospective-cohort-study
#7
Hsing-Kang Chen, Chia-Jung Hsieh
OBJECTIVE: The risk of gastrointestinal hypomotility (GIHM) with the use of antipsychotic medications in patients with schizophrenia remains inadequately recognized. The aim of this study was to explore the incidence of GIHM and its risks in patients with schizophrenia treated with antipsychotics. METHODS: We conducted a retrospective cohort study using the National Health Insurance Research Database. We identified adult (≥ 20years of age) patients with a first-time diagnosis of schizophrenia or schizoaffective disorder in the Registry for Catastrophic Illness Patients during the period from 2001 to 2011...
October 27, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29106788/early-onset-inguinal-hernia-as-risk-factor-for-schizophrenia-or-related-psychosis-a-nationwide-register-based-cohort-study
#8
(no author information available yet)
OBJECTIVES: In an earlier interview study, we found that more men with familial schizophrenia had undergone inguinal hernia operation, than men with sporadic schizophrenia. However, there are no other studies published specifically on inguinal hernia and schizophrenia. Therefore, the aim of this study was to carry out a Swedish register-based cohort study on the association between inguinal hernia and schizophrenia or related psychosis. METHODS: Data from the Total Population- and Medical Birth-Registers were used to create a cohort of all individuals born in Sweden 1987-1999 (n=1 406 168)...
October 6, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29094161/inflammatory-biomarkers-and-risk-of-schizophrenia-a-2-sample-mendelian-randomization-study
#9
Fernando Pires Hartwig, Maria Carolina Borges, Bernardo Lessa Horta, Jack Bowden, George Davey Smith
Importance: Positive associations between inflammatory biomarkers and risk of psychiatric disorders, including schizophrenia, have been reported in observational studies. However, conventional observational studies are prone to bias, such as reverse causation and residual confounding, thus limiting our understanding of the effect (if any) of inflammatory biomarkers on schizophrenia risk. Objective: To evaluate whether inflammatory biomarkers have an effect on the risk of developing schizophrenia...
November 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29092658/an-unexpected-circumstance-acute-dystonic-reaction-in-the-setting-of-clozapine-administration
#10
Alexander Morris Kaplan, William Bradly Pitts, Iqbal Ahmed
Clozapine is a second-generation antipsychotic typically reserved for refractory psychotic disorders due to its high-risk side effect profile to include agranulocytosis, with its attendant need for regular blood draws. While reports of extrapyramidal symptoms (EPS), including acute dystonic reactions, are exceedingly rare, we present the case of a 44-year-old male with a long-standing history of treatment-resistant schizoaffective disorder and no history of EPS who experienced an acute buccal dystonic reaction in the setting of clozapine initiation and discontinuation of depot and oral risperidone...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29091824/comparing-global-assessment-of-functioning-gaf-and-world-health-organization-disability-assessment-schedule-whodas-2-0-in-schizophrenia
#11
Scott Gspandl, Ryan P Peirson, Ramzi W Nahhas, Tracey Goodman Skale, Douglas S Lehrer
WHODAS-2.0 is a suggested replacement to the GAF in DSM-5. This study's purpose was to assess their comparative correlation in adults with schizophrenia spectrum disorder. 42 individuals with a diagnosis of schizophrenia or schizoaffective disorder were administered both tools and the PANSS. Pearson product moment correlations were computed and the different methods compared using bootstrap. There was no significant correlation between raw WHODAS-2.0 and GAF scores for all participants and a modest correlation between corrected WHODAS-2...
October 27, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29074356/anti-gliadin-antibodies-aga-igg-related-to-peripheral-inflammation-in-schizophrenia
#12
Deanna L Kelly, Haley K Demyanovich, William Eaton, Nicola Cascella, Jessica Jackson, Alessio Fanaso, William T Carpenter
Altered immune function and inflammation are seen in schizophrenia, however, peripheral inflammatory markers are not consistently elevated in all people, suggesting inflammation may be present only in a subgroup. We measured TNF-α and IL-Iβ in 100 people with schizophrenia or schizoaffective disorder and correlated these with antibodies to gliadin, a protein found in wheat, barley and rye that has been found to be elevated in some people with schizophrenia. We hypothesized that higher peripheral antigliadin antibodies (AGA IgG) would be associated with higher peripheral inflammation as measured by TNF-α and IL-1β...
October 23, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29074330/motor-dysfunction-as-an-intermediate-phenotype-across-schizophrenia-and-other-psychotic-disorders-progress-and-perspectives
#13
Dusan Hirjak, Katharina M Kubera, Philipp A Thomann, Robert C Wolf
Primary motor abnormalities (PMA), as found in patients with schizophrenia, are quantitatively and qualitatively distinct markers of motor system abnormalities. PMA have been often referred to phenomena that are present across schizophrenia-spectrum disorders. A dysfunction of frontoparietal and subcortical networks has been proposed as core pathophysiological mechanism underlying the expression of PMA. However, it is unclear at present if such mechanisms are a common within schizophrenia and other psychotic disorders...
October 23, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29064472/genome-wide-association-studies-of-smooth-pursuit-and-antisaccade-eye-movements-in-psychotic-disorders-findings-from-the-b-snip-study
#14
R Lencer, L J Mills, N Alliey-Rodriguez, R Shafee, A M Lee, J L Reilly, A Sprenger, J E McDowell, S A McCarroll, M S Keshavan, G D Pearlson, C A Tamminga, B A Clementz, E S Gershon, J A Sweeney, J R Bishop
Eye movement deviations, particularly deficits of initial sensorimotor processing and sustained pursuit maintenance, and antisaccade inhibition errors, are established intermediate phenotypes for psychotic disorders. We here studied eye movement measures of 849 participants from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study (schizophrenia N=230, schizoaffective disorder N=155, psychotic bipolar disorder N=206 and healthy controls N=258) as quantitative phenotypes in relation to genetic data, while controlling for genetically derived ancestry measures, age and sex...
October 24, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29064090/different-communication-strategies-for-disclosing-a-diagnosis-of-schizophrenia-and-related-disorders
#15
REVIEW
Saeed Farooq, Rupinder K Johal, Charlotte Ziff, Farooq Naeem
BACKGROUND: Delivering the diagnosis of a serious illness is an important skill in most fields of medicine, including mental health. Research has found that communication skills can impact on a person's recall and understanding of the diagnosis, treatment options and prognosis. People may feel confused and perplexed when information about their illness is not communicated properly. Sharing information about diagnosis of a serious mental illness is particularly challenging. The nature of mental illness is often difficult to explain since there may be no clear aetiology, and the treatment options and prognosis may vary enormously...
October 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29061200/a-neuropsychiatric-case-report-kl%C3%A3-ver-bucy-and-gastaut-geschwind-syndromes-in-one-patient-with-schizoaffective-disorder-presenting-with-brain-99-mtc-hmpao-single-photon-emission-computed-tomography-showing-bilateral-discrete-decrease-of-temporal-lobes-perfusion
#16
https://www.readbyqxmd.com/read/29058945/the-role-of-controlled-substance-use-in-diversion-outcomes-among-mentally-ill-offenders-a-pilot-study
#17
Jennifer K Boland, Barry Rosenfeld
Diversion programs offer opportunities to offenders with substance abuse or mental illness to attend treatment as an alternative to incarceration. The present study identified variables associated with drug relapse and recidivism and the moderating role of substance use on recidivism in a diversion sample. Data were collected from 80 clients with psychotic disorders from a diversion program in New York City. Outcomes were examined after 6 and 12 months of program participation. Individuals who used controlled substances other than alcohol or cannabis were more likely to have a positive toxicology result than those who used alcohol or cannabis only or those with no alcohol/drug history...
October 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29052964/brief-interactive-psychoeducation-for-caregivers-of-patients-with-early-phase-psychosis-in-yogyakarta-indonesia
#18
Carla R Marchira, Irwan Supriyanto, Subandi Subandi, Mary Jo D Good, Byron J Good
AIM: Brief psychoeducation for families of psychotic patients has been shown to significantly increase family members' knowledge of the disorder. This increase is associated with reductions in relapse and rehospitalization. The aim of this study was to assess the effectiveness of brief psychoeducation about schizophrenia to caregivers of patients in early phases of psychotic disorders in Yogyakarta, Indonesia. METHODS: This study was a prospective, randomized trial with 2 parallel groups...
October 20, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29045304/effect-of-clozapine-vs-other-second-generation-antipsychotics-on-hospitalization-and-seclusion-a-retrospective-mirror-image-study-in-a-japanese-public-psychiatric-hospital
#19
Fuminari Misawa, Takefumi Suzuki, Yasuo Fujii
BACKGROUND: Clozapine has been regarded as the gold standard for patients with treatment-resistant schizophrenia, but a recent network meta-analysis has questioned its relative superiority over other second-generation antipsychotics (SGAs) such as olanzapine and risperidone. PURPOSE: We conducted a retrospective mirror-image study of clozapine vs other SGAs to evaluate real-world effectiveness of clozapine in terms of the duration of hospitalization and seclusion, both of which represent a critical outcome...
October 17, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29042823/digital-health-technology-for-use-in-patients-with-serious-mental-illness-a-systematic-review-of-the-literature
#20
REVIEW
Sonal Batra, Ross A Baker, Tao Wang, Felicia Forma, Faith DiBiasi, Timothy Peters-Strickland
BACKGROUND: As the capabilities and reach of technology have expanded, there is an accompanying proliferation of digital technologies developed for use in the care of patients with mental illness. The objective of this review was to systematically search published literature to identify currently available health technologies and their intended uses for patients with serious mental illness. MATERIALS AND METHODS: The Medline, Embase, and BIOSIS Previews electronic databases were searched to identify peer-reviewed English language articles that reported the use of digital, mobile, and other advanced technology in patients with schizophrenia/schizoaffective disorder, bipolar disorder, and major depressive disorder...
2017: Medical Devices: Evidence and Research
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