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https://www.readbyqxmd.com/read/29738415/efficacy-of-injecting-platelet-concentrate-combined-with-hyaluronic-acid-for-the-treatment-of-vulvovaginal-atrophy-in-postmenopausal-women-with-history-of-breast-cancer-a-phase-2-pilot-study
#1
Barbara Hersant, Mounia SidAhmed-Mezi, Yazid Belkacemi, Franklin Darmon, Sylvie Bastuji-Garin, Gabrielle Werkoff, Romain Bosc, Jeremy Niddam, Oana Hermeziu, Simone La Padula, Jean Paul Meningaud
OBJECTIVE: Approximately 50% to 70% of breast cancer survivors are affected by one or more symptoms of vulvovaginal atrophy (VVA). For those who cannot take hormone therapy, autologous platelet-rich plasma combined with hyaluronic acid (A-PRP-HA) may provide a new alternative therapy for the treatment of VVA in postmenopausal women with history of breast cancer. METHODS: We enrolled 20 postmenopausal breast cancers survivors with VVA and a score of <15 on the Gloria Bachman Vaginal Health Index (VHI) comprised of five items including: vaginal pH, elasticity, fluid volume (secretions), epithelial integrity, and moisture...
May 7, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29730315/cardiometabolic-risk-and-female-sexuality-part-i-risk-factors-and-potential-pathophysiological-underpinnings-for-female-vasculogenic-sexual-dysfunction-syndromes
#2
REVIEW
Elisa Maseroli, Irene Scavello, Linda Vignozzi
INTRODUCTION: Erectile dysfunction is recognized as an opportunity for preventing cardiovascular (CV) events, and assessing the impairment of penile vascular flow by Doppler ultrasound is an important tool to ascertain CV risk. Conversely, the role of genital vascular impairment in the pathophysiology of female sexual dysfunction (FSD) remains contentious. AIM: To focus on the current scientific support for an association between CV risk factors and female sexual health in the 1st part of a 2-part review...
May 2, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29688353/fungal-stress-database-fsd-a-repository-of-fungal-stress-physiological-data
#3
Erzsébet Orosz, Nathalie van de Wiele, Tamás Emri, Miaomiao Zhou, Vincent Robert, Ronald P de Vries, István Pócsi
: http://www.fung-stress.org/.
January 1, 2018: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29673911/targeting-the-rhoa-rock-pathway-to-regulate-t-cell-homeostasis-in-hypoxia-induced-pulmonary-arterial-hypertension
#4
Cheng Li, Ping-Ping Liu, Dou-Dou Tang, Rong Song, Yi-Qing Zhang, Si Lei, Shang-Jie Wu
BACKGROUND: Hypoxic pulmonary arterial hypertension (PAH) is a crippling disease with limited therapeutic methods. The imbalance of T helper 17 cell (Th17)/regulatory T cell (Treg) plays an important role in the development of Hypoxic PAH. However, whether targeting the ras homolog family member A-Rho kinase (RhoA-ROCK) pathway (activation and inhibition) by lysophosphatidic acid (LPA) and fasudil (FSD) regulate T-cell homeostasis in Hypoxic PAH remain unknown. OBJECTIVE: To examine the effects of LPA and FSD on hypoxic pulmonary vascular remodeling and homeostasis of Th17/Treg cells in Hypoxic PAH...
April 16, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29661689/cardiometabolic-risk-and-female-sexuality-part-ii-understanding-and-overcoming-gender-differences-the-key-role-of-an-adequate-methodological-approach
#5
REVIEW
Elisa Maseroli, Irene Scavello, Linda Vignozzi
INTRODUCTION: Although basic science and clinical research indicate that the vascular physiopathology of male and female sexual dysfunction (FSD) is similar, to date the association between FSD and cardiovascular (CV) diseases has been only marginally explored. AIM: To discuss the potential reasons for differences in the role of CV diseases and risk factors in sexual function in women vs men in the 2nd part of a 2-part review. METHODS: A thorough literature search of peer-reviewed publications on the topic was performed using the PubMed database...
April 13, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29652201/trunk-control-and-functionality-in-children-with-spastic-cerebral-palsy
#6
Gulce Kallem Seyyar, Bahar Aras, Ozgen Aras
PURPOSE: To investigate the relationship between trunk control in sitting and functionality in children with spastic cerebral palsy (CP). METHODS: Fifty-eight children with spastic CP were included in the study. Functional abilities were evaluated with the Gross Motor Function Measurement-88 (GMFM-88) and the Pediatric Evaluation of Disability Inventory Functional Skills domain (PEDI-FSD). Trunk control in sitting was tested with the Trunk Control Measurement Scale (TCMS) and the Trunk Impairment Scale (TIS)...
April 13, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29599608/intraoperative-frozen-section-diagnosis-of-bile-duct-margin-for-extrahepatic-cholangiocarcinoma
#7
Takayuki Shiraki, Hajime Kuroda, Atsuko Takada, Yoshimasa Nakazato, Keiichi Kubota, Yasuo Imai
AIM: To evaluate the usefulness of frozen section diagnosis (FSD) of bile duct margins during surgery for extrahepatic cholangiocarcinoma (CCA). METHODS: We retrospectively analyzed 74 consecutive patients who underwent surgery for extrahepatic CCA from 2012 to 2017, during which FSD of bile duct margins was performed. They consisted of 40 distant and 34 perihilar CCAs (45 and 55 bile duct margins, respectively). The diagnosis was classified into three categories: negative, borderline (biliary intraepithelial neoplasia-1 and 2, and indefinite for neoplasia), or positive...
March 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29563770/a-new-surgical-approach-for-punctal-occlusion-using-fibrous-tissue-from-under-the-lacrimal-caruncle
#8
Norihiko Yokoi, Aoi Komuro, Chie Sotozono, Shigeru Kinoshita
Purpose: Surgical punctal occlusion is indispensable for the treatment of severe dry eye in cases where punctal-plug insertion is not applicable due to an enlarged or deformed punctum. However, permanent punctal occlusion is difficult in some cases. In our aim to establish a more reliable punctal occlusion, we have devised a new surgical approach for punctal occlusion. Patients and methods: This study involved 20 puncta of 12 eyes of 12 patients (1 male and 11 females; mean age: 65...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29526644/a-novel-approach-for-accelerating-mouse-abdominal-mri-by-combining-respiratory-gating-and-compressed-sensing
#9
Alexandre Rodrigues Farias, Daniel de Castro Medeiros, Hermes Aguiar Magalhães, Márcio Flávio Dutra Moraes, Eduardo M A M Mendes
PURPOSE: To combine the technique of respiratory gating and compressed sensing (CS) with the objective of accelerating mouse abdominal magnetic resonance imaging (MRI). MATERIALS AND METHODS: To obtain the maximum acceleration, phase-encoding data from a phantom and mouse were obtained on a 4.7 Tesla scanner using the respiratory gating technique. The fully sampled data (FSD) were used to construct reference images and to provide samples to simulate retrospective undersampled data (UD) acquisition using respiratory gating...
March 8, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29485038/a-practical-guide-to-female-sexual-dysfunction-an-evidence-based-review-for-physicians-in-canada
#10
REVIEW
Yonah Krakowsky, Ethan D Grober
INTRODUCTION: Female sexual dysfunction (FSD) is characterized as distress related to sexual pain, sexual arousal, sexual desire, and/or orgasmic dysfunction. Despite prevalence rates similar to male sexual dysfunction, women with sexual complaints have been long under-evaluated, treated, and studied. Over the last decade there have been advances in the medical evaluation and management of FSD, however, there remains a paucity of clinical resources available for women in Canada with sexual dysfunction...
February 23, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29451038/effect-of-finasteride-particle-size-reduction-on-its-pharmacokinetic-tissue-distribution-and-cellular-permeation
#11
Tarek A Ahmed, Ahmed M Al-Abd
Finasteride (FSD), a specific competitive inhibitor of the steroid type-II 5α-reductase enzyme, is used in treatment of benign prostate hyperplasia (BPH) and male pattern baldness. The drug is of limited solubility that affect its dissolution and bioavailability. The aim was to study the effect of FSD particle size reduction on the pharmacokinetic, tissue distribution and cellular permeation. An optimized drug micro- and nano-particles were developed, characterized, administered to group of rats, and systemic pharmacokinetic and tissue distribution within target and not-target organs were determined using near-infrared (NIR) spectroscopy technique...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29402732/female-sexual-dysfunction-a-systematic-review-of-outcomes-across-various-treatment-modalities
#12
REVIEW
James M Weinberger, Justin Houman, Ashley T Caron, Jennifer Anger
BACKGROUND: Female sexual dysfunction (FSD) is a highly prevalent condition. Nevertheless, the scientific literature has only recently begun to accumulate evidence for treatment modalities that address the underlying etiologies of FSD. AIM: The purpose of this systematic review is to elucidate what treatments are effective across the various symptom complexes of FSD. METHODS: Utilizing Meta-analysis of Observational Studies in Epidemiology guidelines, we conducted a systematic review of PubMed, EMBASE, clinicaltrials...
February 3, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29396022/ignorance-is-not-bliss-if-we-don-t-understand-hypoactive-sexual-desire-disorder-how-can-flibanserin-treat-it-commentary
#13
REVIEW
Ryan Anderson, Claire E Moffatt
BACKGROUND: Female sexual dysfunction (FSD) affects as many as 1 in every 3 women, with a significant portion of these with hypoactive sexual desire disorder (HSDD). These figures alone present significant psychological and pharmacologic challenges. Partly in response to this situation, in 2015 the US Food and Drug Administration approved flibanserin for the treatment of HSDD. This approval has drawn criticism on the grounds of efficacy and necessity. AIM: To better inform potential consumers about FSD, flibanserin and other interventions for the treatment of HSDD, the importance of understanding the mechanism of FSD, and the efficacy of flibanserin and to review existing relevant knowledge...
March 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29370851/subclinical-hypothyroidism-would-not-lead-to-female-sexual-dysfunction-in-chinese-women
#14
Han Luo, Wanjun Zhao, Hongliu Yang, Qianqian Han, Li Zeng, Huairong Tang, Jingqiang Zhu
BACKGROUND: There is dearth of research about female sexual dysfunction (FSD), especially in China, because of conservative beliefs. Previous studies indicated the relationship between subclinical hypothyroidism and anxiety and depression. However, there is dearth of research regarding the relationship between subclinical hypothyroidism and FSD in Chinses women. METHOD: A hospital-based research was conducted. Female sexual function was measured by CVFSFI which includes 19 items...
January 25, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29370764/key-components-of-the-delirium-syndrome-and-mortality-greater-impact-of-acute-change-and-disorganised-thinking-in-a-prospective-cohort-study
#15
R A Diwell, D H Davis, V Vickerstaff, E L Sampson
BACKGROUND: Delirium increases the risk of mortality during an acute hospital admission. Full syndromal delirium (FSD) is associated with greatest risk and subsyndromal delirium (SSD) is associated with intermediate risk, compared to patients with no delirium - suggesting a dose-response relationship. It is not clear how individual diagnostic symptoms of delirium influence the association with mortality. Our objectives were to measure the prevalence of FSD and SSD, and assess the effect that FSD, SSD and individual symptoms of delirium (from the Confusion Assessment Method-short version (s-CAM)) have on mortality rates...
January 25, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29370611/re-female-sexual-dysfunction-fsd-prevalence-and-impact-on-quality-of-life-qol
#16
Allen D Seftel
No abstract text is available yet for this article.
August 2017: Journal of Urology
https://www.readbyqxmd.com/read/29278235/role-of-hormones-in-hypoactive-sexual-desire-disorder-and-current-treatment
#17
Ahmed AlAwlaqi, Houda Amor, Mohamed E Hammadeh
Over the decades, female sexual dysfunction (FSD) has grown to be an increasingly potential problem that complicates the quality of life among women. In the current review, FSD refers to recurrent and persistent problems with sexual orgasm, desire, or response. One of the most common subtypes of FSD that has evoked increased research interest in the scientific community is hyposexuality. Today, there is a consensus that hyposexuality is a multifactorial condition that manifests with reduced sexual desire resulting in significant interpersonal distress...
December 15, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29249205/attention-vigilance-and-visuospatial-function-in-hospitalized-elderly-medical-patients-relationship-to-delirium-syndromal-status-and-motor-subtype-profile
#18
Cara Daly, Maeve Leonard, Henry O'Connell, Olugbenga Williams, Fahad Awan, Chris Exton, Margaret O'Connor, Dimitrios Adamis, Colum P Dunne, Walter Cullen, David J Meagher
BACKGROUND: The early and effective detection of neurocognitive disorders poses a key diagnostic challenge. We examined performance on common cognitive bedside tests according to differing delirium syndromal status and clinical (motor) subtypes in hospitalized elderly medical inpatients. METHODS: A battery of nine bedside cognitive tests was performed on elderly medical inpatients with DSM-IV delirium, subsyndromal delirium (SSD), and no delirium (ND). Patients with delirium were compared according to clinical (motor) subtypes...
December 18, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29244742/fibrinogen-gamma-chain-mutations-provoke-fibrinogen-and-apolipoprotein-b-plasma-deficiency-and-liver-storage
#19
Francesco Callea, Isabella Giovannoni, Sinan Sari, Esendagli Guldal, Buket Dalgic, Gulen Akyol, Tsuyoshi Sogo, Abdulrahman Al-Hussaini, Giuseppe Maggiore, Andrea Bartuli, Renata Boldrini, Paola Francalanci, Emanuele Bellacchio
p.R375W (Fibrinogen Aguadilla) is one out of seven identified mutations (Brescia, Aguadilla, Angers, Al du Pont, Pisa, Beograd, and Ankara) causing hepatic storage of the mutant fibrinogen γ. The Aguadilla mutation has been reported in children from the Caribbean, Europe, Japan, Saudi Arabia, Turkey, and China. All reported children presented with a variable degree of histologically proven chronic liver disease and low plasma fibrinogen levels. In addition, one Japanese and one Turkish child had concomitant hypo-APOB-lipoproteinemia of unknown origin...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29240550/the-relationship-between-menopausal-symptoms-and-sexual-function
#20
Soheila Nazarpour, Masoumeh Simbar, Fahimeh Ramezani Tehrani, Hamid Alavi Majd
Sexual function could be affected by several factors in postmenopausal women. This cross-sectional study aimed to investigate the relationship between the severity of menopausal symptoms and sexual function. The study was conducted among 405 postmenopausal women aged 40-65 years, in Chalous and Noshahr, Iran, from October 2013 to May 2014. The participants were selected using a multistage sampling method. The instruments used for data collection were the Female Sexual Function Index (FSFI), the Menopause Rating Scale (MRS), and a demographics questionnaire...
December 14, 2017: Women & Health
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