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Apathy and Parkinson's disease

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https://www.readbyqxmd.com/read/28822071/imaging-the-etiology-of-apathy-anxiety-and-depression-in-parkinson-s-disease-implication-for-treatment
#1
REVIEW
Stephane Thobois, Stephane Prange, Véronique Sgambato-Faure, Léon Tremblay, Emmanuel Broussolle
Apathy, depression, and anxiety are among the most important non-motor signs of Parkinson's disease (PD). This may be encountered at early stages of illness and represent a major source of burden. Understanding their pathophysiology is a major prerequisite for efficient therapeutic strategies. Anatomical and metabolic imaging studies have enabled a breakthrough by demonstrating that widespread abnormalities within the limbic circuits notably the orbitofrontal and anterior cingulate cortices, amygdala, thalamus, and ventral striatum are involved in the pathophysiology of depression, anxiety, and apathy in PD...
August 18, 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28805568/complementary-and-alternative-medicine-and-exercise-in-nonmotor-symptoms-of-parkinson-s-disease
#2
Indu Subramanian
The use of complementary and alternative medicine (CAM) therapy in nonmotor symptoms (NMS) for Parkinson disease (PD) is growing worldwide. Well-performed, systematic evidence-based research is largely lacking in this area and many studies include various forms of CAM with small patient numbers and a lack of standardization of the approaches studied. Taichi, Qigong, dance, yoga, mindfulness, acupuncture, and other CAM therapies are reviewed and there is some evidence for the following: Taichi in sleep and PDQ39; dance in cognition, apathy, and a mild trend to improved fatigue; yoga in PDQ39; and acupuncture in depression, PDQ39, and sleep...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28803229/non-motor-symptoms-assessed-by-non-motor-symptoms-questionnaire-and-non-motor-symptoms-scale-in-parkinson-s-disease-in-selected-asian-populations
#3
Anna Sauerbier, Onanong Jitkritsadakul, Nataliya Titova, Lisa Klingelhoefer, Yoshio Tsuboi, Harry Carr, Hrishikesh Kumar, Rebecca Banerjee, Roberto Erro, Roongroj Bhidayasiri, Anette Schrag, Panagiotis Zis, Shen-Yang Lim, J Y Al-Hashel, Walaa A Kamel, Pablo Martinez-Martin, K Ray Chaudhuri
BACKGROUND: Ethnic variations have been described in medical conditions, such as hypertension, diabetes, and multiple sclerosis. Whether ethnicity plays a role in Parkinson's disease (PD), particularly with regard to non-motor symptoms (NMS), remains unclear. Existing literature is diverse, controversial, and inadequately documented. This review aims to analyse and report the currently available literature on NMS, specifically in Asian PD patients. SUMMARY: We conducted a literature review using PubMed, searching for articles and currently available publications that reference and assess NMS in PD patients living in Asia using the validated NMS Questionnaire (NMS Quest) and NMS Scale (NMSS)...
August 12, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/28802937/apathy-in-parkinson-s-disease
#4
Javier Pagonabarraga, Jaime Kulisevsky
The normal maintenance of human motivation depends on the integrity of subcortical structures that link the medial and lateral prefrontal cortex with the limbic system. Apathy is highly prevalent in Parkinson's disease and causes major impact on the quality of life of patients and caregivers, comparable to depression or cognitive impairment. The clinical differentiation of apathy from the emotional symptoms of depression, and from difficulties in planning or organizing mental programs as a consequence of executive dysfunction, may guide a rationale for individualized treatment approach of apathetic symptoms, which is presently lacking...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28802929/caregiver-burden-and-the-nonmotor-symptoms-of-parkinson-s-disease
#5
Jon P Hiseman, Robin Fackrell
Parkinson's disease has traditionally been considered as primarily a motor disorder (Chaudhuri & Schapira, 2009). It is clear however that it is the burden of the nonmotor symptomatology which impacts significantly more highly on caregiver burden and quality of life (Benavides, Alberquerque, & Chana-Cuevas, 2013; Martinez-Martin, 2011). As Parkinson's disease advances there is an almost inevitable accrual of nonmotor symptoms alongside the motor aspects of the disease. Patients as their disease progresses require increasing support and this is not infrequently provided by an informal caregiver, most typically a spouse or family member (Martinez-Martin, Forjaz, Frades-Payo, et al...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28797564/impact-of-anxiety-apathy-and-reduced-functional-autonomy-on-perceived-quality-of-life-in-parkinson-s-disease
#6
Alfonsina D'Iorio, Carmine Vitale, Fausta Piscopo, Chiara Baiano, Anna Paola Falanga, Katia Longo, Marianna Amboni, Paolo Barone, Gabriella Santangelo
INTRODUCTION: Parkinson's disease (PD) is characterized by a wide spectrum of non-motor symptoms that may impact negatively on the activities of the patient's daily life and reduce Health-related quality of life (HRQoL). The present study explored the impact of specific non-motor symptoms on the HRQoL in PD. METHODS: Eighty-four outpatients underwent the Montreal Cognitive Assessment (MoCA) assessing global functioning and several questionnaires to assess depression, apathy, impulse control disorders (ICD), anxiety, anhedonia and functional impact of cognitive impairment...
August 5, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28796560/facial-emotion-decoding-in-patients-with-parkinson-s-disease
#7
Marco De Risi, Giancarlo Di Gennaro, Angelo Picardi, Sara Casciato, Liliana G Grammaldo, Alfredo D'Aniello, Deborah Lanni, Stefano Meletti, Nicola Modugno
PURPOSE: In line with the growing attention on non-motor symptoms and disturbance of affective and emotional processing in Parkinson's disease, we aimed to study different aspects of facial emotion expression evaluation in a group of PD without cognitive decline in treatment with common antiparkinsonian drugs, matched for sex, age, and education with healthy subjects. MATERIALS AND METHODS: The study was conducted on 30 patients (13 male; mean age: 63.3±6.7; mean age of disease onset: 56...
August 10, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28789795/neurobiological-correlates-of-emotional-processing-in-parkinson-s-disease-a-systematic-review-of-experimental-studies
#8
REVIEW
Anja J H Moonen, Anke Wijers, Kathy Dujardin, Albert F G Leentjens
Deficits in emotional processing in patients with Parkinson's disease (PD) have received increasing interest over the past decades. In this systematic review, we present the results of 18 behavioral studies that have examined the neurobiological base of emotional processing in PD. Multiple aspects of emotional processing have been studied, using a variety of research methods. Deficits in PD are mainly related to autonomic and perceptive processing of intense emotional stimuli, which is accompanied by structural and functional neurobiological abnormalities in predominantly ventral regions of affective neurocircuitry...
September 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28780181/white-matter-tract-alterations-in-parkinson-s-disease-patients-with-punding
#9
Elisa Canu, Federica Agosta, Vladana Markovic, Igor Petrovic, Iva Stankovic, Francesca Imperiale, Tanja Stojkovic, Massimiliano Copetti, Vladimir S Kostic, Massimo Filippi
OBJECTIVE: To assess brain white matter tract alterations in patients with Parkinson's disease and punding (PD-punding) compared with controls and PD cases without any impulsive-compulsive behaviour. METHODS: Forty-nine PD patients (21 PD-punding and 28 PD with no impulsive-compulsive behaviours) and 28 controls were consecutively recruited. Clinical, cognitive and psychopathological evaluations were performed. Diffusion tensor MRI metrics of the main white matter tracts were assessed using a tractography approach...
July 27, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28725706/the-effect-of-deep-brain-stimulation-on-the-non-motor-symptoms-of-parkinson-s-disease-a-critical-review-of-the-current-evidence
#10
REVIEW
Mónica M Kurtis, Thadshani Rajah, Luisa F Delgado, Haidar S Dafsari
The benefit of deep brain stimulation (DBS) in controlling the motor symptoms of Parkinson's disease is well established, however, the impact on the non-motor symptoms (NMS) remains to be elucidated, although the growing investigative efforts are promising. This article reviews the reported data and considers the level of evidence available with regard to the effect of DBS on NMS total burden and on the cognitive, neuropsychiatric, sleep, pain, dysautonomic, and weight domains. Multiple case series suggest that DBS improves the burden of NMS by reducing prevalence, intensity, and non-motor fluctuations...
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/28711816/unilateral-subthalamotomy-in-parkinson-s-disease-cognitive-psychiatric-and-neuroimaging-changes
#11
Ignacio Obeso, Enrique Casabona, Rafael Rodríguez-Rojas, Maria Luisa Bringas, Raúl Macías, Nancy Pavón, Jose A Obeso, Marjan Jahanshahi
Unilateral subthalamotomy is an effective treatment for the cardinal motor features of Parkinson's disease (PD). However, non-motor changes possibly associated with right or left subthalamotomy remain unknown. Our aim was to assess cognitive, psychiatric and neuroimaging changes after treatment with unilateral subthalamotomy. Fourteen medicated patients with PD were evaluated before and after (mean 6 months after operation) unilateral subthalamotomy (5 right, 9 left). In addition to motor assessments, cognitive (global cognition and executive functions), psychiatric (apathy, depression, anxiety, mania, hypo- and hyperdopaminergic behaviours, impulsivity), quality of life evaluations and volume of lesions were obtained...
June 27, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28689673/the-anatomy-of-apathy-a-neurocognitive-framework-for-amotivated-behaviour
#12
C Le Heron, M A J Apps, M Husain
Apathy is a debilitating syndrome associated with many neurological disorders, including several common neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, and focal lesion syndromes such as stroke. Here, we review neuroimaging studies to identify anatomical correlates of apathy, across brain disorders. Our analysis reveals that apathy is strongly associated with disruption particularly of dorsal anterior cingulate cortex (dACC), ventral striatum (VS) and connected brain regions...
July 8, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28676310/an-investigation-into-the-effects-and-prognostic-factors-of-cognitive-decline-following-subthalamic-nucleus-stimulation-in-patients-with-parkinson-s-disease
#13
Taro Nimura, Ken-Ichi Nagamatsu, Tadashi Ando, Arifumi Matsumoto, Kinya Hisanaga, Teiji Tominaga
We retrospectively investigated the effects of subthalamic nucleus stimulation (STN-DBS) on new postoperative onset of cognitive decline and prognostic factors for advanced Parkinson's disease (PD). We studied 39 PD patients who had received bilateral STN-DBS. Clinical symptoms, cognitive function, psychiatric function, and health-related quality of life (HRQOL) were assessed before and six months after surgery. Based on the results of neuropsychological examinations six months after the surgery, the subjects were divided into those with and those without cognitive decline...
July 1, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28651750/reduced-orexin-immunoreactivity-in-perry-syndrome-and-multiple-system-atrophy
#14
Takayasu Mishima, Koji Kasanuki, Shunsuke Koga, Monica Castanedes-Casey, Zbigniew K Wszolek, Yoshio Tsuboi, Dennis W Dickson
INTRODUCTION: Orexin is a neuropeptide that plays a key role in maintaining a state of arousal, and possibly associates with sleep apnea syndrome (SAS). Reduced orexin immunoreactivity has been reported in various neurologic conditions such as narcolepsy, Alzheimer's disease, Lewy body disease and multiple system atrophy (MSA); however, there has been no report investigating orexin in Perry syndrome, a rare hereditary neurodegenerative disease characterized by four clinical cardinal signs (parkinsonism, depression/apathy, weight loss, and central hypoventilation)...
June 12, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28648111/reduction-of-white-matter-integrity-correlates-with-apathy-in-parkinson-s-disease
#15
Yang Zhang, Jiayong Wu, Wenbo Wu, Renyuan Liu, Lingen Pang, Dening Guan, Yun Xu
BACKGROUND: Apathy is a common non-movement symptom in Parkinson's disease (PD), but little is known about apathy and white matter (WM) change. In this study, we investigated whether fractional anisotropy (FA) of the WM can distinguish apathetic patients from non-apathetic PD patients, and whether FA value correlates with the severity of apathy in PD. METHODS: Thirty nine PD patients were participated in our study, of which 18 participants with apathy symptom, and 21 without apathy symptom...
June 26, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28643887/personality-dopamine-and-parkinson-s-disease-insights-from-subthalamic-stimulation
#16
Eugénie Lhommée, François Boyer, Maxime Wack, Pierre Pélissier, Hélène Klinger, Emmanuelle Schmitt, Amélie Bichon, Valérie Fraix, Stéphan Chabardès, Patrick Mertens, Anna Castrioto, Andrea Kistner, Emmanuel Broussolle, Stéphane Thobois, Paul Krack
BACKGROUND: Subthalamic stimulation improves the motor and neuropsychiatric symptoms of Parkinson's disease. However, the impact of this treatment on impulse control and personality is the subject of heavy debate. The objective of this study was to investigate personality changes after subthalamic stimulation. METHODS: Using Cloninger's biosocial model, we assessed personality in 73 Parkinson's disease patients before and 12 months after subthalamic stimulation accompanied by a drastic reduction in dopaminergic medication...
June 23, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28637374/facial-emotion-recognition-in-parkinson-s-disease-association-with-age-and-olfaction
#17
S Kalampokini, E Lyros, M Luley, J Schöpe, J Spiegel, J Bürmann, U Dillmann, K Fassbender, M M Unger
OBJECTIVE: The ability to recognize facial emotion expressions has been reported to be impaired in Parkinson's disease (PD), yet previous studies showed inconsistent findings. The aim of this study was to further investigate facial emotion recognition (FER) in PD patients and its association with demographic and clinical parameters (including motor and nonmotor symptoms). METHOD: Thirty-four nondemented PD patients and 24 age- and sex-matched healthy controls (HC) underwent clinical neurological and neuropsychological assessment, standardized olfactory testing with Sniffin' Sticks, and the Ekman 60 Faces Emotion Recognition Test...
June 21, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28624436/zonisamide-inhibits-monoamine-oxidase-and-enhances-motor-performance-and-social-activity
#18
Maiko T Uemura, Takeshi Asano, Rie Hikawa, Hodaka Yamakado, Ryosuke Takahashi
Zonisamide (ZNS) is an effective drug for not only motor symptoms but also non-motor symptoms in Parkinson's disease. However, the actions of ZNS as an anti-Parkinsonian drug are not well understood. To clarify the actions of ZNS in vivo, we administered ZNS to mice and examined the effects on neurotransmitter metabolism and behaviors, focusing on motor and non-motor symptoms. Administration of ZNS decreased dopamine (DA) turnover in various brain regions, including the striatum. In behavioral tests, ZNS enhanced locomotor activity and novelty seeking in the open field test, light-dark transition test, and the social interaction test...
June 15, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28612623/frontal-tasks-and-behavior-in-rigid-or-tremor-dominant-parkinson-disease
#19
Rita Moretti, Vera Milner, Paola Caruso, Silvia Gazzin, Raffaella Rumiati
Parkinson disease (PD) is not an unambiguous entity, and there is a general consensus for the statement that an akinetic-rigid dominant type of presentation has a worse prognosis, in the follow-up. The aim of our study was to examine the differences in frontal tasks and behavior, in 2 PD naive groups: the rigid and the tremor-dominant types of presentation, according to motor scores. Our study has showed some important differences in frontal tasks and in behavior, performing more apathy, aggressiveness, and irritability in the rigid type, and more depression and anxiety in the tremor-dominant type...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28597694/everyday-functioning-of-people-with-parkinson-s-disease-and-impairments-in-executive-function-a-qualitative-investigation
#20
Aleksandra Kudlicka, John V Hindle, Laura E Spencer, Linda Clare
PURPOSE: Executive function is the key area of cognitive impairment in Parkinson's disease. This study investigated how cognitive difficulties impact on everyday life of people with Parkinson's disease and their carers, and whether they explicitly mention executive-type difficulties. METHODS: Semistructured interviews with 11 people with Parkinson's disease and six carers were analyzed thematically. People with Parkinson's disease performed within the normal range on cognitive screening tests, but all had abnormal scores on tests of executive function...
June 9, 2017: Disability and Rehabilitation
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