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Apathy and Parkinson's disease

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https://www.readbyqxmd.com/read/29215769/can-a-cognitive-rehabilitation-program-in-early-stages-of-parkinson-s-disease-improve-cognition-and-apathy-and-brain-functional-connectivity-for-up-to-18-months
#1
Antonio Daniele, Francesco Panza
In patients with Parkinson's disease (PD), management of non-motor symptoms, including cognitive and behavioural symptoms, is still a challenging need [1], which may be approached by various therapeutic strategies. A randomized controlled trial (RCT) in PD patients showed that a 13-week cognitive rehabilitation program training various cognitive functions (attention, memory, language, executive functions, social cognition) may improve cognition and functional disability [2]. Diez-Cirarda et al. [3] report the results obtained in 15 PD patients in early disease stages, as 18-month follow-up study of such RCT [2]...
December 7, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29209182/cognitive-emotional-and-auto-activation-dimensions-of-apathy-in-parkinson-s-disease
#2
REVIEW
Jonathan Del-Monte, Sophie Bayard, Pierluigi Graziani, Marie C Gély-Nargeot
Apathy is one of the most frequent non-motor manifestations in Parkinson's disease (PD) that can lead to a whole range of deleterious outcomes. In 2006, Levy and Dubois proposed a model that distinguishes three different apathy aetiologies in PD divided into three subtypes of disrupted processing: "emotional-affective," "cognitive," and "auto-activation." These three dimensions associated with dopamine depletion present in the pathology would lead to the emergence of apathy in PD. The aim of this mini-review was to describe and discuss studies that have explore links between apathy and the three subtypes of disrupted processing proposed by Levy and Dubois (2006) and as well as the links between these dimensions and dopamine depletion in Parkinson's disease...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29131091/apathy-profile-in-parkinson-s-and-huntington-s-disease-a-comparative-cross-sectional-study
#3
Mário Sousa, Fradique Moreira, Joana Jesus-Ribeiro, Inês Marques, Flávia Cunha, Nádia Canário, António Freire, Cristina Januário
BACKGROUND/AIMS: Apathy is one of the most frequent, disabling and difficult-to-treat symptoms that show up in many neurodegenerative disorders. The aim of this study was to assess and compare apathy profile in Parkinson's and Huntington's patients using the same comprehensive instruments to measure apathy, cognition and depressive symptoms. MATERIALS AND METHODS: We consecutively assessed Parkinson's disease (PD) and Huntington's disease (HD) patients recruited from a Movement Disorders Unit...
November 13, 2017: European Neurology
https://www.readbyqxmd.com/read/29114969/apathy-in-rapid-eye-movement-sleep-behaviour-disorder-is-common-and-under-recognised
#4
Thomas R Barber, Kinan Muhammed, Daniel Drew, Michael Lawton, Marie Crabbe, Michal Rolinski, Timothy Quinnell, Zenobia Zaiwalla, Yoav Ben-Shlomo, Masud Husain, Michele Tm Hu
BACKGROUND: Apathy is an important neuropsychiatric feature of Parkinson's disease (PD), which often emerges before the onset of motor symptoms. Patients with rapid eye movement sleep behaviour disorder (RBD) have a high probability of developing Parkinson's disease in future. Neuropsychiatric problems are common in RBD, but apathy has not previously been detailed in this key prodromal population. METHODS: 88 patients with polysomnographically proven RBD, 65 patients with PD and 33 controls were assessed for apathy using the Lille Apathy Rating Scale (LARS)...
November 8, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29100973/evaluating-psychiatric-symptoms-in-parkinson-s-disease-by-a-clinimetric-analysis-of-the-hopkins-symptom-checklist-scl-90-r
#5
Danilo Carrozzino, Bo Mohr Morberg, Chiara Siri, Gianni Pezzoli, Per Bech
Although psychiatric comorbidity in Parkinson's Disease (PD) has often been studied, the individual psychiatric symptoms have rarely been evaluated from a clinimetric point of view in an attempt to measure how much the symptoms have been bothering or distressing the PD patients. The current study is therefore aimed at evaluating from a clinimetric viewpoint the severity of psychiatric symptoms affecting PD patients by using the Hopkins Symptom Checklist (SCL-90-R) to show its measurement-driven construct validity (scalability)...
November 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29097256/the-pathophysiological-mechanisms-of-motivational-deficits-in-parkinson-s-disease
#6
REVIEW
A Chagraoui, L Boukhzar, F Thibaut, Y Anouar, D Maltête
Parkinson's disease (PD) is a progressive degenerative disorder that leads to disabling motor symptoms and a wide variety of neuropsychiatric symptoms. Apathy is the most common psychiatric disorder in the early stages of untreated PD and can be defined as a hypodopaminergic syndrome, which also includes anxiety and depression. Apathy is also considered the core feature of the parkinsonian triad (apathy, anxiety and depression) of behavioural non-motor signs, including a motivational deficit. Moreover, apathy is recognised as a distinct chronic neuropsychiatric behavioural disorder based on specific diagnostic criteria...
October 31, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29089398/establishing-diagnostic-criteria-for-perry-syndrome
#7
Takayasu Mishima, Shinsuke Fujioka, Hiroyuki Tomiyama, Ichiro Yabe, Ryoichi Kurisaki, Naoki Fujii, Ryuji Neshige, Owen A Ross, Matthew J Farrer, Dennis W Dickson, Zbigniew K Wszolek, Nobutaka Hattori, Yoshio Tsuboi
OBJECTIVE: To establish international diagnostic criteria for Perry syndrome, a disorder characterised by clinical signs of parkinsonism, depression/apathy, weight loss, respiratory symptoms, mutations in the DCTN1 gene and TAR DNA-binding protein 43 (TDP-43) pathology. METHODS: Data from the published literature and newly identified patients were gathered and analysed during and after the International Symposium on Perry syndrome in Tokyo to identify diagnostic criteria for Perry syndrome...
October 31, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29038946/cognitive-and-behavioral-disorders-in-parkinson-s-disease-an-update-ii-behavioral-disorders
#8
Luigi Trojano, Costanza Papagno
Patients with Parkinson's disease (PD) can experience several behavioral symptoms, such as apathy, agitation, hypersexuality, stereotypic movements, pathological gambling, abuse of antiparkinsonian drugs, and REM sleep behavioral disorders. Psychoses and hallucinations, depression and anxiety disorders, and difficulties in recognizing and experiencing emotions also impair behavior and can cause severe psychosocial problems in patients with PD. Symptoms can be present since early stages of the disease, sometimes even before the appearance of classical motor symptoms, likely in relation to dopamine depletion in basal ganglia and/or to dysfunctions of other neurotrasmitter systems, and others can develop later, in some cases in relation to dopaminergic treatment...
October 16, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29037500/motor-behavioural-and-cognitive-correlates-of-fatigue-in-early-de-novo-parkinson-disease-patients
#9
M Siciliano, L Trojano, R De Micco, A De Mase, F Garramone, A Russo, G Tedeschi, A Tessitore
INTRODUCTION: Fatigue is one of the most common and disabling non-motor symptoms in Parkinson's disease (PD). The objective of this study was to determine prevalence and motor, behavioural, and cognitive correlates of distressing fatigue in early, de novo PD patients. METHODS: Eighty-one consecutive de novo PD patients (64% men; mean age 65.73 ± 8.26 years) underwent a comprehensive examination, including Parkinson's disease Fatigue Scale (PFS), Epworth Sleepiness Scale (ESS), Parkinson's Disease Sleep Scale (PDSS), Beck Depression Inventory (BDI), Parkinson's Anxiety Scale (PAS), and Apathy Evaluation Scale (AES)...
October 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29037499/neuropsychiatric-and-cognitive-profile-of-early-richardson-s-syndrome-progressive-supranuclear-palsy-parkinsonism-and-parkinson-s-disease
#10
Clelia Pellicano, Francesca Assogna, Nystya Cellupica, Federica Piras, Mariangela Pierantozzi, Alessandro Stefani, Rocco Cerroni, Bruno Mercuri, Carlo Caltagirone, Francesco E Pontieri, Gianfranco Spalletta
INTRODUCTION: The two main variants of Progressive Supranuclear Palsy (PSP), Richardson's syndrome (PSP-RS) and PSP-parkinsonism (PSP-P), share motor and non-motor features with Parkinson's disease (PD) particularly in the early stages. This makes the precocious diagnosis more challenging. We aimed at defining qualitative and quantitative differences of neuropsychiatric and neuropsychological profiles between PSP-P, PSP-RS and PD patients recruited within 24 months after the onset of symptoms, in order to clarify if the identification of peculiar cognitive and psychiatric symptoms is of help for early PSP diagnosis...
October 6, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29037342/-pharmacological-treatment-of-apathy-in-parkinson-s-disease-a-systematic-review-of-the-literature
#11
Jorge Carlos Holguín Lew, Jessica Caamaño Jaraba, Alejandra Gómez Alzate, Catalina Hidalgo López, Daniel Felipe Marino Mondragón, Sebastián Restrepo Moreno, Liz Evelin Rico Abella
INTRODUCTION AND OBJECTIVES: Apathy, defined as a deficit for initiating and maintaining action, is a symptom affecting patients with diverse psychiatric and neuropsychiatric diseases, including dementia, sequelae of traumatic brain injury, schizophrenia, depression, and Parkinson's disease (PD). Apathy negatively affects function and quality of life of PD patients, and it is an important cause of caregiver's distress. The pharmacological treatment of apathy in PD is the focus of this systematic review...
October 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/29037340/-neuropsychiatry-of-movement-disorders
#12
Juan Manuel Orjuela-Rojas, Gustavo Adolfo Barrios Vincos, Melisa Alejandra Martínez Gallego
Movement disorders can be defined as neurological syndromes presenting with excessive or diminished automatic or voluntary movements not related to weakness or spasticity. Both Parkinson's disease (PD) and Huntington's disease (HD) are well-known examples of these syndromes. The high prevalence of comorbid psychiatric symptoms like depression, anxiety, obsessive-compulsive symptoms, hallucinations, delusions, impulsivity, sleep disorders, apathy and cognitive impairment mean that these conditions must be regarded as neuropsychiatric diseases...
October 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/29032789/symptom-dimensions-of-depression-and-apathy-and-their-relationship-with-cognition-in-parkinson-s-disease
#13
Sarah M Szymkowicz, Vonetta M Dotson, Jacob D Jones, Michael S Okun, Dawn Bowers
OBJECTIVES: Both depression and apathy, alone and in combination, have been shown to negatively affect cognition in patients with Parkinson's disease (PD). However, the influence of specific symptom dimensions of depression and apathy on cognition is not well understood. The current study investigated the relationship between symptom dimensions of depression and apathy, based on factors identified in Kirsch-Darrow et al. (2011), and memory and executive function in PD. METHODS: A sample of 138 non-demented individuals with PD (mean age=64...
October 16, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28994369/-motivation-and-apathy-in-parkinson-s-disease-implication-of-dopaminergic-d3-receptors
#14
Mathieu Favier, Carole Carcenac, Marc Savasta, Sébastien Carnicella
No abstract text is available yet for this article.
October 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28951497/effects-of-dopaminergic-depletion-and-brain-atrophy-on-neuropsychiatric-symptoms-in-de-novo-parkinson-s-disease
#15
Byoung Seok Ye, Seun Jeon, Sohoon Yoon, Seong Woo Kang, KyoungWon Baik, Yoonju Lee, Su Jin Chung, Jungsu S Oh, Hyojeong Moon, Jae Seung Kim, Phil Hyu Lee, Young Ho Sohn
BACKGROUND: Neuropsychiatric symptoms impact the patients' quality of life and caregivers' burdens in Parkinson's disease (PD). We aimed to investigate the effects of striatal dopaminergic depletion and brain atrophy on the neuropsychiatric symptoms of patients with PD. METHODS: Two hundred and seven patients with de novo drug-naïve PD underwent dopamine transporter (DAT) positron emission tomography and brain MRI scanning. In addition, the patients were assessed with caregiver-administered neuropsychiatric inventory (NPI) questionnaires...
September 26, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28939804/separate-neural-representations-of-depression-anxiety-and-apathy-in-parkinson-s-disease
#16
Rotem Dan, Filip Růžička, Ondrej Bezdicek, Evžen Růžička, Jan Roth, Josef Vymazal, Gadi Goelman, Robert Jech
Depression, anxiety and apathy are distinct neuropsychiatric symptoms that highly overlap in Parkinson's disease (PD). It remains unknown whether each symptom is uniquely associated with a functional network dysfunction. Here, we examined whether individual differences in each neuropsychiatric symptom predict functional connectivity patterns in PD patients while controlling for all other symptoms and motor function. Resting-state functional connectivity MRI were acquired from 27 PD patients and 29 healthy controls...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28919975/mild-cognitive-impairment-in-parkinson-s-disease-a-distinct-clinical-entity
#17
REVIEW
Ming-Ching Wen, Ling Ling Chan, Louis C S Tan, Eng King Tan
BACKGROUND: Mild cognitive impairment in Parkinson's disease (PD-MCI) is a common clinical condition. Understanding its pathology and clinical features is important for early intervention before the onset of dementia. In the past, variable definitions and differences in neuropsychological batteries generated divergent results of the affected cognitive patterns. MAIN BODY: The introduction of PD-MCI criteria by the Movement Disorders Society (MDS) Task Force provides a more uniform system for defining and measuring PD-MCI and may improve the validity of future research...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28918694/brain-metabolic-correlates-of-fatigue-in-parkinson-s-disease-a-pet-study
#18
Li Zhang, Tiannv Li, Yongsheng Yuan, Qing Tong, Siming Jiang, Min Wang, Jianwei Wang, Jian Ding, Qinrong Xu, Kezhong Zhang
The neural bases of fatigue in Parkinson's disease (PD) remain uncertain. We aimed to assess the brain metabolic correlates of fatigue in patients with PD. Twenty-seven PD patients without clinically relevant depression (17-item Hamilton Depression Rating Scale [HAMD] score ≥ 14), apathy (Apathy Scale [AS] score ≥ 14) and excessive daytime somnolence (Epworth Sleepiness Scale [ESS] score ≥ 10) were evaluated with Fatigue Severity Scale (FSS). Each patient had an F-18 fluorodeoxyglucose PET (FDG-PET) scan...
September 18, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28874701/restless-legs-syndrome-in-parkinson-disease-clinical-characteristics-abnormal-iron-metabolism-and-altered-neurotransmitters
#19
Ying-Shan Piao, Teng-Hong Lian, Yang Hu, Li-Jun Zuo, Peng Guo, Shu-Yang Yu, Li Liu, Zhao Jin, Hui Zhao, Li-Xia Li, Qiu-Jin Yu, Rui-Dan Wang, Sheng-Di Chen, Piu Chan, Xiao-Min Wang, Wei Zhang
Relationships among clinical characteristics, iron metabolism and neurotransmitters in Parkinson disease (PD) patients with restless legs syndrome (RLS) remains unclear. We divided 218 patients into PD with and with no RLS (PD-RLS and PD-NRLS) groups by RLS-rating scale (RLS-RS) score. Motor and non-motor symptoms were rated by related scales. Iron and related proteins, and neurotransmitters in cerebrospinal fluid (CSF) and serum were measured. PD-RLS frequency was 40.37%. PD-RLS group had longer duration, higher stage and scores of motor symptoms, depression, anxiety, sleep disorders, fatigue and apathy, and increased transferrin and decreased iron, ferritin, dopamine (DA) and 5-hydroxytryptamine (5-HT) in CSF...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28871794/differentiating-between-apathy-and-depression-in-patients-with-parkinson-disease-dementia
#20
Carlos Henrique Ferreria Camargo, Rafael Arthur Serpa, Vinícius Aguiar Jobbins, Frederico Antonio Berbetz, Jivago Szpoganicz Sabatini
In Parkinson disease (PD), apathy and depression often overlap, making it difficult to differentiate between them. This study sought to analyze apathy and depression in patients with PD dementia (PDD). Forty patients were diagnosed with PDD using the Movement Disorder Society criteria. A statistically significant correlation was identified between worsening dementia and an improvement in depression ( r = .3695; r(2) = .1365, 95% confidence interval [CI]: 0.0985 to 05.894, P = .0044) and between worsening dementia and worsening apathy ( r = -...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
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