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https://www.readbyqxmd.com/read/29793178/nrf2-p-glycoprotein-axis-is-associated-with-clinicopathological-characteristics-in-colorectal-cancer
#1
Mohammad Reza Sadeghi, Farhad Jeddi, Narges Soozangar, Mohammad Hossein Somi, Masoud Shirmohamadi, Vahid Khaze, Nasser Samadi
Colorectal cancer (CRC) is the fourth leading cause of cancer-related death worldwide. Activation of ABCB1 gene and its main product, P-glycoprotein, is the common reason for chemoresistance. The nuclear factor-erythroid 2-related factor2 (Nrf2) is directly regulated by Kelch like ECH-associated protein1 (Keap1). In addition, Nrf2 is a key transcriptional factor that regulates efflux transporters, including P-gp. The aim of this study was to investigate the expression levels of Nrf2, Keap1 and ABCB1 in the biopsy samples and their association with clinicopathological features in CRC patients...
May 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29789762/percutaneous-computed-tomography-guided-permanent-125-i-implantation-as-therapy-for-pulmonary-metastasis
#2
Xiaodong Huo, Bin Huo, Huixing Wang, Lei Wang, Qiang Cao, Guangjun Zheng, Junjie Wang, Shude Chai, Zuncheng Zhang, Kuo Yang, Yuanjie Niu, Haitao Wang
Purpose: To evaluate intermediate-term outcomes after computed tomography (CT)-guided radioactive 125 I seed implantation (CTRISI), and to determine prognostic variables associated with outcomes in patients with pulmonary metastases. Material and methods: Thoracic surgeons evaluated and performed implantation of 125 I radioactive seeds under CT guidance or combined with surgical resection. Patients were monitored in the thoracic surgery clinic for recurrence and survival...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29787819/budding-and-tumor-infiltrating-lymphocytes-combination-of-both-parameters-predicts-survival-in-colorectal-cancer-and-leads-to-new-prognostic-subgroups
#3
Corinna Lang-Schwarz, Balint Melcher, Franziska Haumaier, Klaus Lang-Schwarz, Thomas Rupprecht, Michael Vieth, William Sterlacci
Tumor budding is an independent prognostic factor in colorectal cancer (CRC) and has recently been well defined by the International Concensus Conference on Tumor Budding (ITBCC). Tumor infiltrating lymphocytes (TILs) are also an issue in different human cancers and correlate with prognosis in CRC. Here we evaluate the combination of budding and TILs in CRC with regard to prognosis. Hematoxylin and Eosin (H&E) stained slides of 501 CRC patients, diagnosed between 2005 and 2010 were reevaluated for tumor budding according to the ITBCC-criteria...
May 19, 2018: Human Pathology
https://www.readbyqxmd.com/read/29784873/chemokine-c-x-c-motif-ligand-1-cxcl1-is-associated-with-tumor-progression-and-poor-prognosis-in-patients-with-colorectal-cancer
#4
Changhua Zhuo, Xianyi Wu, Jing Li, Dan Hu, Jinliang Jian, Changjiang Chen, Xiongwei Zheng, Chunkang Yang
Chemokine (C-X-C motif) ligand 1 (CXCL1) is a chemotactic cytokine known to regulate cancer progression and invasion. However, the prognostic significance of CXCL1 expression in colorectal cancer (CRC) has not been fully characterized. This study explored the clinicopathological significance and potential role of CXCL1 in the carcinogenesis and progression of CRC. The protein expression of CXCL1 was measured immunohistochemically in tissue microarrays constructed from 276 CRC patients. CXCL1 expression levels and their associations with clinicopathological characteristics and patient survival were evaluated...
May 21, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29783958/sanguinarine-triggers-intrinsic-apoptosis-to-suppress-colorectal-cancer-growth-through-disassociation-between-strap-and-melk
#5
Xianling Gong, Zhihong Chen, Qinrui Han, Chunhui Chen, Linlin Jing, Yawei Liu, Liang Zhao, Xueqing Yao, Xuegang Sun
BACKGROUND: Previous studies showed sanguinarine induced apoptosis in CRC cells but did not define the underlying mechanisms. The purpose of this work was to determine the in vivo and in vitro effects of sanguinarine on CRC tumors and to elucidate the mechanism in regulating the intrinsic apoptosis. METHODS: Cell viability of CRC cell lines treated with sanguinarine was measured by MTT assay. Apoptotic cells stained with Annexin V and 7-AAD were detected by flow cytometry...
May 21, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29783886/the-impact-of-surgical-resection-of-the-primary-tumor-on-the-development-of-synchronous-colorectal-liver-metastasis-a-systematic-review
#6
H Pinson, S Cosyns, Wim P Ceelen
BACKGROUND: In recent years different therapeutic strategies for synchronously liver metastasized colorectal cancer were described. Apart from the classical staged surgical approach, simultaneous and liver-first strategies are now commonly used. One theoretical drawback of the classical approach is, however, the stimulatory effect on liver metastases growth that may result from resection of the primary tumour. This systematic review, therefore, aims to investigate the current insights on the stimulatory effects of colorectal surgery on the growth of synchronous colorectal liver metastases in humans...
May 22, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29782466/mucin-expression-in-colorectal-cancer-crc-systematic-review-and-meta-analysis
#7
Yaron Niv, Theodore Rokkas
BACKGROUND: A body of evidence has suggested that mucins play an important role in adhesion, invasion, and cancer metastasis. However, this evidence is scarce and sometimes confusing. OBJECTIVE: We performed a systematic review and meta-analysis of available studies to better define the role of mucins in the behavior of colorectal cancer (CRC). METHODS: Medical literature was searched through November 30, 2017, using suitable keywords. Pooled estimates, that is, odd ratios (ORs), were obtained using fixed or random-effects models, as appropriate...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29781848/anatomical-resections-improve-survival-following-lung-metastasectomy-of-colorectal-cancer-harboring-kras-mutations
#8
Stéphane Renaud, Joseph Seitlinger, Yaseen Al Lawati, Francesco Guerrera, Pierre-Emmanuel Falcoz, Gilbert Massard, Lorenzo Ferri, Jonathan Spicer
OBJECTIVE: The aim of this study was to evaluate the benefit of anatomical resection (AR) in lung metastasectomy (LM) of colorectal cancer (CRC) harboring KRAS mutations SUMMARY BACKGROUND DATA:: KRAS mutations are related to high aggressiveness in the lung metastasis of CRC. It is unknown whether AR can lead to better outcomes than can non-AR (NAR) in KRAS patients. METHODS: We retrospectively reviewed the data from 574 consecutive patients who underwent a LM for CRC...
May 17, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29781053/expression-of-nox-family-genes-and-their-clinical-significance-in-colorectal-cancer
#9
Sang Yeon Cho, Ju Seok Kim, Hyuk Soo Eun, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong, Hee Seok Moon
BACKGROUND: The NADPH oxidase (NOX) family is overexpressed in many cancers and is associated with cancer cell proliferation and metastasis; however, little is known about the role of the NOX family in colorectal cancer (CRC). AIMS: To identify the expression of the NOX family in CRC and to investigate the relationship between the expression of NOXs with the prognosis of the patients. METHODS: In the TCGA data portal, mRNA expression data were obtained from 41 normal samples and 458 CRC samples to analyze mRNA expression and gene alteration...
May 21, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29781037/microrna-485-plays-tumour-suppressive-roles-in-colorectal-cancer-by-directly-targeting-gab2
#10
Jibin Li, Jian Xu, Xiaofei Yan, Keer Jin, Wenya Li, Rui Zhang
Colorectal cancer (CRC) is reported to be the third most common cancer and the fourth leading cause of cancer-related deaths around the world. MicroRNA-485 (miR-485) has been reported to be aberrantly expressed and play important roles in several types of human malignancy. However, the expression level, biological functions and underlying molecular mechanisms of miR-485 in CRC remain unclear. Therefore, the aim of the present study was to determine miR-485 expression levels and their clinical significance in CRC and to explore the functions and underlying mechanisms of miR-485 in this disease...
May 17, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29779391/-is-preoperative-systemic-chemotherapy-recommended-for-resectable-colorectal-liver-metastases-oncosurgical-aspects
#11
Kristóf Dede, Zsuzsa Póti, Attila Bursics
Surgical resection is still the only curative treatment for colorectal liver metastases, but this is one part of a complex therapy. Nowadays a patient with colorectal liver metastasis is not treated only by a surgeon or by an oncologist or even only by an invasive radiologist. Collective decisions, complement treatments give the only chance to treat these patients for longer time. Patients with colorectal liver metastases could be regarded as patients with chronic disease. Specially interesting are the various treatment options of resectable colorectal liver metastases...
May 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29776371/lncrna-tug1-promoted-kiaa1199-expression-via-mir-600-to-accelerate-cell-metastasis-and-epithelial-mesenchymal-transition-in-colorectal-cancer
#12
Junfeng Sun, Jiyi Hu, Guojun Wang, Zhen Yang, Chunlin Zhao, Xiefu Zhang, Jiaxiang Wang
BACKGROUND: LncRNA TUG1 has been reported to be highly expressed in CRC samples and cells and promoted metastasis by affecting EMT, indicating a poor prognosis for colorectal cancer (CRC). In this study, we determined the underlying mechanism for tumor oncogenesis of lncRNA TUG1 in CRC metastasis. METHODS: The expressions of miR-600 and KIAA1199 in 76 CRC patients and CRC cells and CRC metastatic tissues were determined using qRT-PCR. Epithelial-mesenchymal transition (EMT)-related proteins were determined using western blot...
May 18, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29774414/tumoral-cavitation-in-colorectal-cancer-patients-with-unresectable-lung-metastasis-treated-with-bevacizumab-and-chemotherapy
#13
REVIEW
Yu Peng, Ye Chen, Xi Zhang, Yu Yang, Dan Cao, Feng Bi, Zhipi Li, Hongfeng Gou
PURPOSE: Efficacy and the frequency of tumor cavitation have not been investigated in patients with metastatic colorectal cancer (mCRC) and lung metastases (LMs) treated with chemotherapy in combination with bevacizumab. This study was aimed to evaluate the efficacy and safety of bevacizumab for unresectable mCRC with LM and to determine the frequency of tumor cavitation, and its correlation with clinical outcomes in patients receiving bevacizumab plus chemotherapy. METHODS: Patients with mCRC and LMs treated with bevacizumab as first- or second-line therapy at West China Hospital, Sichuan University Cancer Center from September 2010 to November 2016 were included in this retrospective study...
May 17, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29768262/mir-598-suppresses-invasion-and-migration-by-negative-regulation-of-derlin-1-and-epithelial-mesenchymal-transition-in-non-small-cell-lung-cancer
#14
Fengming Yang, Ke Wei, Zhiqiang Qin, Weitao Liu, Chuchu Shao, Chaoshan Wang, Ling Ma, Mengyan Xie, Yongqian Shu, Hua Shen
BACKGROUND/AIMS: MicroRNAs regulate a wide range of biological processes of non-small cell lung cancer (NSCLC). Although miR-598 has been reported to act as a suppressor in osteosarcoma and colorectal cancer, the physiological function of miR-598 in NSCLC remains unknown. In this study, the role of miR-598 in NSCLC was investigated. METHODS: Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to estimate the expression of miR-598 and Derlin-1 (DERL1) in both NSCLC tissues and cell lines...
May 11, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29767249/trim27-functions-as-an-oncogene-by-activating-epithelial-mesenchymal-transition-and-p-akt-in-colorectal-cancer
#15
Yue Zhang, Yifei Feng, Dongjian Ji, Qingyuan Wang, Wenwei Qian, Shijia Wang, Zhiyuan Zhang, Bing Ji, Chuan Zhang, Yueming Sun, Zan Fu
Tripartite motif‑containing 27 (TRIM27) belongs to the tripartite motif (TRIM) protein family and is involved in various malignant tumor processes. However, the function and mechanism of TRIM27 in colorectal cancer (CRC) remains to be elucidated. In the present study, the expression of TRIM27 was analyzed in CRC tissues and adjacent normal tissues by reverse transcription‑quantitative polymerase chain reaction and immunohistochemistry. LoVo and HCT116 cell lines were then selected to further investigate the function of TRIM27 in the proliferation, invasion and metastasis of CRC in vitro and in vivo...
May 16, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29766649/lysyl-oxidase-a-colorectal-cancer-biomarker-of-lung-and-hepatic-metastasis
#16
Yun Liu, Guanghui Wang, Zhonglin Liang, Zubing Mei, Tingyu Wu, Ang Cui, Chenying Liu, Long Cui
BACKGROUND: Colorectal cancer (CRC) is a common and lethal disease in which distant metastasis remains the primary cause of death. Paradoxical roles of LOX have been reported in CRC, and the intracellular function of LOX has also recently been determined. Correlations of LOX expression and its intracellular localization with clinicopathological features in CRC patients remain largely unknown. The aim of the present study was to explore the potential roles of LOX in CRC. METHODS: LOX messenger RNA expression was assayed by quantitative PCR in eight paired normal mucosa and tumor tissues...
May 15, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29766240/pulmonary-thermal-ablation-enables-long-chemotherapy-free-survival-in-metastatic-colorectal-cancer-patients
#17
Mariane Fonck, Jean-Thomas Perez, Vittorio Catena, Yves Becouarn, Laurent Cany, Eric Brudieux, Laure Vayre, Patrick Texereau, Valérie Le Brun-Ly, Véronique Verger, Véronique Brouste, Dominique Bechade, Xavier Buy, Jean Palussière
BACKGROUND: Chemotherapy (ct) is the preferred treatment option in metastatic colorectal cancer (mCRC). The objective of the study was to determine the overall survival (OS), disease-free survival (DFS) and ct-free survival (CFS) of pulmonary thermal ablation (TA) and its place in the treatment of mCRC. PATIENTS AND METHODS: All consecutive patients treated (over 11 years) with percutaneous TA for lung metastasis of colorectal origin were reviewed. All sequences of treatments were considered...
May 15, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29765533/-gstm1-gstt1-and-gstp1-polymorphisms-and-colorectal-cancer-risk-in-polish-nonsmokers
#18
Justyna Klusek, Anna Nasierowska-Guttmejer, Artur Kowalik, Iwona Wawrzycka, Piotr Lewitowicz, Magdalena Chrapek, Stanisław Głuszek
Glutathione S-transferase (GST) enzymes are responsible for cellular detoxification of many carcinogens and are important anticancer elements. This study assessed potential relationships between GSTM1 , GSTT1 , and GSTP1 polymorphisms and colorectal cancer (CRC) risk in Polish nonsmokers. We also analyzed the influence of GST gene polymorphisms on CRC clinical and histopathological features. Our study included 197 CRC patients and 104 healthy controls. GSTM1 , GSTT1 , and GSTP1 polymorphisms were evaluated using qPCR...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29765511/immunohistochemical-analysis-of-rhamm-expression-in-normal-and-neoplastic-human-tissues-a-cell-cycle-protein-with-distinctive-expression-in-mitotic-cells-and-testicular-germ-cells
#19
Yao-Tseng Chen, Zhengming Chen, Yi-Chieh Nancy Du
Expression of Receptor for Hyaluronic Acid Mediated Motility (RHAMM) increases cellular motility and RHAMM overexpression promotes invasive phenotype and metastasis of cancer cells. RHAMM has been suggested as a biomarker for poor prognosis in several tumor types, including lung, breast, colorectal, gastric, pancreatic ductal, and ovarian cancers. RNA studies showed restricted RHAMM expression in normal tissues, but its protein expression data in tissues were limited. In light of its potential as a prognostic marker and a therapeutic target, we performed immunohistochemical analysis to systematically characterize RHAMM expression in normal and neoplastic human tissues...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29764504/long-term-outcomes-of-endoscopic-submucosal-dissection-for-high-grade-dysplasia-and-early-stage-carcinoma-in-the-colorectum
#20
Tao Chen, Wen-Zheng Qin, Li-Qing Yao, Yun-Shi Zhong, Yi-Qun Zhang, Wei-Feng Chen, Jian-Wei Hu, Marie Ooi, Ling-Li Chen, Ying-Yong Hou, Mei-Dong Xu, Ping-Hong Zhou
BACKGROUND: Colorectal carcinomas (CRCs) arise from premalignant precursors in an adenoma-carcinoma sequence, in which adenoma with high-grade dysplasia (HGD) and early-stage carcinoma are defined as advanced neoplasia. A limited number of studies have evaluated the long-term outcomes of endoscopic submucosal dissection (ESD) for advanced colorectal neoplasia. This study aimed to assess the efficacy and safety of ESD for advanced colorectal neoplasia as well as the long-term outcomes, including local recurrence and metastasis...
March 21, 2018: Cancer communications
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