keyword
https://read.qxmd.com/read/38516391/pharmacist-management-of-atrial-fibrillation-in-uk-primary-care-a-cross-sectional-study
#21
JOURNAL ARTICLE
Shahd Al-Arkee, Julie Mason, M Sayeed Haque, Abdullah Alshehri, Zahraa Jalal
BACKGROUND: Atrial Fibrillation (AF) increases the risk of stroke by a factor of five, leading a significant cost burdens on healthcare system. Pharmacists, especially those based in a primary care environment are well placed to support patients in this therapeutic area. OBJECTIVES: To assess primary care pharmacists' actual knowledge on the management of AF symptoms and anticoagulation. Furthermore, to investigate the resources used by pharmacists. METHODS: A cross-sectional study using survey was conducted, targeting UK-based registered pharmacists employed within primary care settings...
2024: Journal of Pharmaceutical Policy and Practice
https://read.qxmd.com/read/38516287/mechanical-thrombectomy-using-double-stent-retriever-technique-for-acute-ischemic-stroke-following-embolism-from-the-pulmonary-vein-stump-after-left-upper-lobectomy-a-case-report
#22
Haruki Hirata, Yuta Kaneshiro, Yumiko Urano, Keiji Murata
Acute ischemic stroke (AIS) following pulmonary lobectomy, which is traditionally attributed to air embolism and atrial fibrillation (AF), may occur after thrombus formation in the pulmonary vein stump (PVS). Herein, we document the mechanical thrombectomy (MT) of a carotid bifurcation occlusion post-left upper lobectomy (LUL) to manage AIS. A 76-year-old male with a history of diabetes, dyslipidemia, and a treated dural arteriovenous fistula at the transverse sigmoid junction, with no history of AF, successfully underwent LUL for a pulmonary tumor...
March 2024: Curēus
https://read.qxmd.com/read/38515032/overcoming-barriers-for-left-atrial-appendage-thrombus-a-systematic-review-of-left-atrial-appendage-closure
#23
Zixi Zhang, Jiabao Zhou, Qiuzhen Lin, Cancan Wang, Yunying Huang, Yongguo Dai, Wanyun Zuo, Na Liu, Yichao Xiao, Qiming Liu
BACKGROUND: Approximately 90% of intracardial thrombi originate from the left atrial appendage in non-valvular atrial fibrillation patients. Even with anticoagulant therapy, left atrial appendage thrombus (LAAT) still occurs in 8% of patients. While left atrial appendage closure (LAAC) could be a promising alternative, the current consensus considers LAAT a contraindication to LAAC. However, the feasibility and safety of LAAC in patients with LAAT have yet to be determined. METHODS: This systematic review synthesizes published data to explore the feasibility and safety of LAAC for patients with LAAT...
March 21, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38514850/enhancing-the-evaluation-of-acute-ischemic-stroke-risk-in-individuals-with-non-valvular-atrial-fibrillation-by-including-laboratory-indicators
#24
JOURNAL ARTICLE
Xin Hou, Xiaohong Zhang
To investigate the clinical significance of the CHA2 DS2 -VASc-60 score, lipoprotein (a) [Lp(a)], red blood cell distribution width (RDW), and their combined effect in patients with non-valvular atrial fibrillation (NVAF) who experience acute ischemic stroke (AIS). This retrospective analysis was conducted on the clinical data of hospitalized patients with NVAF at the Third Affiliated Hospital of Anhui Medical University between April 1, 2020, and April 1, 2023. Based on the diagnosis of acute ischemic stroke (AIS), the patients were divided into two groups: the AIS group (150 cases of NVAF patients with comorbid AIS) and the non-AIS group (163 cases of NVAF patients without AIS)...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38512023/association-of-impaired-left-ventricular-mitral-filling-from-4d-flow-cardiac-mri-and-prognosis-of-hypertrophic-cardiomyopathy
#25
JOURNAL ARTICLE
Hichem Sakhi, Gilles Soulat, Damian Craiem, Umit Gencer, Jérôme Lamy, Valentina Stipechi, Tania Puscas, Jean-Sébastien Hulot, Albert Hagege, Elie Mousseaux
Purpose To investigate whether the peak early filling rate normalized to the filling volume (PEFR/FV) estimated from four-dimensional (4D) flow cardiac MRI may be used to assess impaired left ventricular (LV) filling and predict clinical outcomes in individuals with hypertrophic cardiomyopathy (HCM). Materials and Methods Cardiac MRI with a 4D flow sequence and late gadolinium enhancement (LGE), as well as echocardiography, was performed in 88 individuals: 44 participants with HCM from a French prospective registry (ClinicalTrials...
April 2024: Radiology. Cardiothoracic imaging
https://read.qxmd.com/read/38511348/back-to-the-future-observational-studies-and-anticoagulant-selection-for-nonvalvular-atrial-fibrillation
#26
EDITORIAL
Melina Gattellari
No abstract text is available yet for this article.
March 21, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38511316/effectiveness-and-safety-of-edoxaban-compared-with-apixaban-in-elderly-patients-with-nonvalvular-atrial-fibrillation-a-real-world-population-based-cohort-study
#27
JOURNAL ARTICLE
Richard Chiv, Sarah Beradid, Samy Suissa, Christel Renoux
BACKGROUND: The very elderly (≥80 years) are at high risk of nonvalvular atrial fibrillation and thromboembolism. Given its recent approval, the comparative effectiveness and safety of edoxaban in this population, relative to the commonly used apixaban, remain unknown. METHODS: Using the United Kingdom Clinical Practice Research Datalink, we identified a cohort of patients aged ≥80 with incident nonvalvular atrial fibrillation and newly treated with edoxaban or apixaban between 2015 and 2021...
March 21, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38511307/eye-toward-stroke-prevention-central-retinal-artery-occlusion-and-tandem-internal-carotid-artery-occlusion
#28
JOURNAL ARTICLE
Chrisoula Cheronis, Andrew Silverman, Paul M George
No abstract text is available yet for this article.
March 21, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38510951/longitudinal-association-of-premature-atrial-contractions-with-atrial-fibrillation-and-brain-ischemia-in-people-with-type-2-diabetes-the-hoorn-diabetes-care-system-cohort
#29
JOURNAL ARTICLE
Peter P Harms, Jelle C L Himmelreich, Marieke T Blom, Joline W J Beulens, Giel Nijpels, Petra Elders, Wim A M Lucassen
BACKGROUND: Premature atrial contractions (PACs) are potential markers for imminent onset of both atrial fibrillation (AF) and brain ischemia (BI; transient ischemic attack [TIA] or ischemic stroke). We investigated the association of PACs with incident AF and BI events separately, and of incident AF with BI events in people with type 2 diabetes (T2D) without pre-existing AF or cerebrovascular disease. METHODS: A prospective longitudinal study of 12,242 people with T2D without known AF or cerebrovascular disease from the Hoorn Diabetes Care System cohort...
October 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38510554/a-review-of-the-impact-pathophysiology-and-management-of-atrial-fibrillation-in-patients-with-heart-failure-with-preserved-ejection-fraction
#30
REVIEW
Cicely Dye, Mark Dela Cruz, Timothy Larsen, Gatha Nair, Karolina Marinescu, Tisha Suboc, Erica Engelstein, Jennifer Marsidi, Priya Patel, Parikshit Sharma, Annabelle Santos Volgman
Patients with heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) have increased mortality and increased risk of stroke. Due to the heterogeneous nature of both disease processes, it is difficult to ascertain whether the diagnosis and progression of AF is the cause of deterioration or if it is a symptom of worsening heart failure. This presents physicians with a clinical conundrum of whether optimizing their heart failure will decrease the overall AF burden or if restoration of sinus rhythm is necessary to optimize patients with HFpEF...
September 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38510506/the-changing-landscape-of-cardiac-co-morbidities-and-in-hospital-cardiac-complications-mediating-covid-19-mortality-between-2020-and-2021
#31
JOURNAL ARTICLE
Thomas R Basala, Marissa E Dulas, Alexis Albers, Sara D Olson, Brynn Okeson, Jay H Traverse
BACKGROUND: Cardiac co-morbidities and in-hospital cardiac complications significantly contribute to COVID-19 mortality. However, their influence on mortality between 2021 and 2020 may differ due to the availability of vaccines, different viral strains, and therapeutic advancements. METHODS: We performed a retrospective chart review and individual patient analysis of all COVID-19 associated in-patient deaths in 2020 ( n  = 346) and 2021( n  = 527) in a large Minneapolis health system...
January 2024: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38508850/genetic-factors-altering-immune-responses-in-atrial-fibrillation-jacc-review-topic-of-the-week
#32
REVIEW
Sandro Ninni, David Dombrowicz, Menno de Winther, Bart Staels, David Montaigne, Stanley Nattel
Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide and is associated with a range of adverse clinical outcomes. Accumulating evidence points to inflammatory processes resulting from innate immune responses as a cornerstone in AF pathogenesis. Genetic and epigenetic factors affecting leukocytes have been identified as key modulators of the inflammatory response. Inherited variants in genes encoding proteins involved in the innate immune response have been associated with increased risk for AF recurrence and stroke in AF patients...
March 26, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38508836/secondary-stroke-prevention-in-people-with-atrial-fibrillation-treatments-and-trials
#33
REVIEW
David J Seiffge, Virginia Cancelloni, Lorenz Räber, Maurizio Paciaroni, Andreas Metzner, Paulus Kirchhof, Urs Fischer, David J Werring, Ashkan Shoamanesh, Valeria Caso
Atrial fibrillation is one of the most common cardiac arrhythmias and is a major cause of ischaemic stroke. Recent findings indicate the importance of atrial fibrillation burden (device-detected, subclinical, or paroxysmal and persistent or permanent) and whether atrial fibrillation was known before stroke onset or diagnosed after stroke for the risk of recurrence. Secondary prevention in patients with atrial fibrillation and stroke aims to reduce the risk of recurrent ischaemic stroke. Findings from randomised controlled trials assessing the optimal timing to introduce direct oral anticoagulant therapy after a stroke show that early start (ie, within 48 h for minor to moderate strokes and within 4-5 days for large strokes) seems safe and could reduce the risk of early recurrence...
April 2024: Lancet Neurology
https://read.qxmd.com/read/38507072/sex-differences-in-clinical-features-utilization-of-oral-anticoagulant-agents-and-one-year-outcome-in-middle-eastern-patients-with-atrial-fibrillation
#34
JOURNAL ARTICLE
Nasr Alrabadi, Mohammed Al-Nusair, Razan Haddad, Basheer S Alghizzawi, Nashmi Al-Nusair, Saleh Alhaj Mohammad, Saif M Shteiwi, Maryam K El-Zubi, Zaid Marie, Ayham Alnsour, Mohamad Jarrah, Karem H Alzoubi, Ayman Hammoudeh
OBJECTIVE: Studies have revealed that sex can predict differences in multiple aspects of atrial fibrillation (AF). These differences are underreported in the Middle East. This study aims to describe sex-specific differences in risk factors, symptomatology, management, and outcomes in Middle Eastern patients with AF. METHODS: The JoFib (Jordan-Atrial-Fibrillation) study is an observational, prospective, multicenter, nationwide registry in AF. Comparisons were made between female and male patients using Pearson chi-square and Mann-Whitney U tests...
March 20, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38507060/factor-xa-inhibitors-versus-warfarin-in-patients-with-morbid-obesity-and-atrial-fibrillation
#35
JOURNAL ARTICLE
Paul Dobry, Kirsten McGrew, Ina Yun, Rebecca Heath, Amna Shafqat, Ascend-Higher, Christopher Giuliano
PURPOSE: Factor Xa Inhibitors have emerged as a first-line agent in the management of non-valvular atrial fibrillation (NVAF), but there is a need for additional data surrounding their use in the morbidly obese population. The purpose of this study was to evaluate whether Factor Xa Inhibitors are as safe and effective as warfarin for the treatment of NVAF in individuals with a BMI ≥ 40 kg/m2 and/or weight ≥ 120 kg. METHODS: This was a multi-center retrospective cohort study comparing the use of Factor Xa Inhibitors (apixaban and rivaroxaban) to warfarin for the management of NVAF in adult patients with a BMI ≥ 40 kg/m2 and/or weight ≥ 120 kg...
March 20, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38506256/alcohol-health-loss-and-mortality-can-wine-really-save-the-good-name-of-moderate-alcohol-consumption
#36
JOURNAL ARTICLE
Stanisław Surma, Grzegorz Gajos
It is estimated that one third of the world's population consumes alcohol. At the same time, it is well-known that excessive alcohol consumption in one of the leading causes of premature mortality. The history of production of alcoholic beverages, especially wine, date as long as 8000 years ago. However, humans soon realized adverse effects of alcohol abuse and tried to limit its consumption. Higher alcohol consumption is associated with health loss and increased risk of all-cause mortality. It is linearly associated with a higher risk of many types of cancers, liver disease, incidence of atrial fibrillation, hemorrhagic stroke, heart failure...
March 20, 2024: Polish Archives of Internal Medicine
https://read.qxmd.com/read/38505564/bleeding-risk-prediction-in-patients-treated-with-antithrombotic-drugs-according-to-the-anatomic-site-of-bleeding-indication-for-treatment-and-time-since-treatment-initiation
#37
JOURNAL ARTICLE
Vinai Bhagirath, Tanya Kovalova, Jia Wang, Lizhen Xu, Shrikant I Bangdiwala, Martin O'Donnell, Ashkan Shoamanesh, Jackie Bosch, Rosa Coppolecchia, Tatsiana Vaitsiakhovich, Frank Kleinjung, Hardi Mundl, John Eikelboom
Background  Reasons for the relatively poor performance of bleeding prediction models are not well understood but may relate to differences in predictors for various anatomical sites of bleeding. Methods  We pooled individual participant data from four randomized controlled trials of antithrombotic therapy in patients with coronary and peripheral artery diseases, embolic stroke of undetermined source (ESUS), or atrial fibrillation. We examined discrimination and calibration of models for any major bleeding, major gastrointestinal (GI) bleeding, and intracranial hemorrhage (ICH), according to the time since initiation of antithrombotic therapy, and indication for antithrombotic therapy...
January 2024: TH Open: Companion Journal to Thrombosis and Haemostasis
https://read.qxmd.com/read/38505191/perioperative-treatment-with-rivaroxaban-and-dabigatran-on-changes-of-coagulation-and-platelet-activation-biomarkers-following-left-atrial-appendage-closure
#38
JOURNAL ARTICLE
Yao Yao, Yanli Li, Qinchun Jin, Xiaoye Li, Xiaochun Zhang, Qianzhou Lv
Insufficient data exist regarding the investigation of the impact of novel oral anticoagulants (NOACs) on coagulation activation biomarkers in the context of left atrial appendage closure (LAAC) and device-related thrombosis (DRT). The study was designed to investigate the changes and presence of coagulation activation biomarkers between different antithrombotic strategies following LAAC. A total of 120 nonvalvular atrial fibrillation patients intolerant of long-term anticoagulants, who underwent successful WATCHMAN closure implantation, were enrolled (rivaroxaban, n = 82; dabigatran, n = 38)...
2024: Cardiovascular Therapeutics
https://read.qxmd.com/read/38505057/postoperative-atrial-fibrillation-poaf-after-cardiac-surgery-clinical-practice-review
#39
REVIEW
Orlando R Suero, Ahmed K Ali, Lauren R Barron, Matthew W Segar, Marc R Moon, Subhasis Chatterjee
Postoperative atrial fibrillation (POAF) after cardiac surgery is associated with elevated morbidity and mortality. Although current prediction models have limited efficacy, several perioperative interventions can reduce patients' risk of POAF. These begin with preoperative medications, including beta-blockers and amiodarone. Moreover, patients should be screened for preexisting atrial fibrillation (AF) so that concomitant surgical ablation and left atrial appendage occlusion can be performed in appropriate candidates...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38504433/bibliometric-insights-into-the-evolution-of-atrial-fibrillation-and-dementia-research-2002-2022
#40
JOURNAL ARTICLE
Yu Zhao, Dianbo Wang
BACKGROUND In response to the escalating prevalence of atrial fibrillation (AF) and its potential correlation with cognitive impairment and dementia, we conducted a comprehensive bibliometric analysis to assess current research trends, contributors, and collaborative networks in this evolving interdisciplinary field. MATERIAL AND METHODS Articles published between 2002 and 2022 were extracted from the Web of Science database and carefully screened, yielding 328 publications. Two reviewers independently conducted the screening and quality appraisal...
March 9, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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