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Atrial fibrillation and remodeling

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https://www.readbyqxmd.com/read/29777140/different-responses-of-left-atrium-and-left-atrial-appendage-to-radiofrequency-catheter-ablation-of-atrial-fibrillation-a-follow-up-mri-study
#1
Yun Gi Kim, Jaemin Shim, Suk-Kyu Oh, Hee-Soon Park, Kwang-No Lee, Sung Ho Hwang, Jong-Il Choi, Young-Hoon Kim
Atrial fibrillation (AF) is known to cause adverse remodeling of left atrium (LA). Radiofrequency catheter ablation (RFCA) of AF is associated with decrease in LA volume. However, the impact of RFCA on left atrial appendage (LAA) volume and hemodynamic function is not fully understood. We analyzed 123 patients who underwent cardiac magnetic resonance imaging (MRI) evaluation before and after RFCA in Korea University Anam Hospital. LA and LAA volume were measured before and after RFCA based on cardiac MRI. Baseline LA volume was 99...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764718/metabolic-syndrome-associates-with-left-atrial-dysfunction
#2
K Nyman, M Granér, M O Pentikäinen, J Lundbom, A Hakkarainen, R Sirén, M S Nieminen, M-R Taskinen, N Lundbom, K Lauerma
BACKGROUND AND AIMS: Obesity and metabolic syndrome (MetS) are risk factors of atrial fibrillation (AF), but limited data exist on their effect on left atrial (LA) function. The aim of the study was to evaluate the effects of cardiac, hepatic and intra-abdominal ectopic fat depots and cardiometabolic risk factors on LA function in non-diabetic male subjects. METHODS AND RESULTS: Myocardial and hepatic triglyceride contents were measured with 1.5T 1 H-magnetic resonance spectroscopy and LA and left ventricular function, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), epicardial and pericardial fat by magnetic resonance imaging (MRI) in 33 men with MetS and 40 men without MetS...
February 21, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29759774/assessment-of-left-atrial-fibrosis-by-late-gadolinium-enhancement-magnetic-resonance-imaging-methodology-and-clinical-implications
#3
REVIEW
Johannes Siebermair, Eugene G Kholmovski, Nassir Marrouche
Recently, studies using late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) to identify structural changes of atrial tissue have contributed significantly to understanding the pathophysiology and progression of atrial fibrillation (AF). Moreover, imaging of atrial fibrosis using MRI has evolved to be a tool to improve clinical outcome of AF ablation procedures by allowing a patient-specific individualized management approach. LGE-MRI has been shown to predict AF ablation outcome based on pre-procedural imaging to define the extent of atrial fibrosis...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759716/atrial-fibrillation-in-athletes-a-lesson-in-the-virtue-of-moderation
#4
REVIEW
N A Mark Estes, Christopher Madias
Although the cardiovascular benefits of moderate exercise are well established, there is growing epidemiological support for the notion that high-intensity endurance athletics increases the risk of atrial fibrillation (AF). There are many gaps in evidence related to epidemiology and mechanisms of AF in endurance athletes. The proposed pathophysiological mechanisms include alterations of autonomic tone, electrical remodeling, anatomical remodeling, fibrosis, and inflammation. Clinical management of the athlete with AF often includes a period of decreased frequency, intensity, and duration of exercise with assessment for improvement in AF recurrence...
September 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29755033/impact-of-a-history-of-hypertension-in-pregnancy-on-later-diagnosis-of-atrial-fibrillation
#5
Dawn C Scantlebury, Andrea G Kattah, Tracey L Weissgerber, Sanket Agarwal, Michelle M Mielke, Amy L Weaver, Lisa E Vaughan, Stanislav Henkin, Katherine Zimmerman, Virginia M Miller, Wendy M White, Sharonne N Hayes, Vesna D Garovic
BACKGROUND: Atrial fibrillation/flutter (AF) produces significant morbidity in women and is typically attributed to cardiac remodeling from multiple causes, particularly hypertension. Hypertensive pregnancy disorders (HPDs) are associated with future hypertension and adverse cardiac remodeling. We evaluated whether women with AF were more likely to have experienced a HPD compared with those without. METHODS AND RESULTS: A nested case-control study was conducted within a cohort of 7566 women who had a live or stillbirth delivery in Olmsted County, Minnesota between 1976 and 1982...
May 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29754254/interplay-between-cardiac-transcription-factors-and-non-coding-rnas-in-predisposing-to-atrial-fibrillation
#6
REVIEW
Alexander T Mikhailov, Mario Torrado
There is growing evidence that putative gene regulatory networks including cardio-enriched transcription factors, such as PITX2, TBX5, ZFHX3, and SHOX2, and their effector/target genes along with downstream non-coding RNAs can play a potentially important role in the process of adaptive and maladaptive atrial rhythm remodeling. In turn, expression of atrial fibrillation-associated transcription factors is under the control of upstream regulatory non-coding RNAs. This review broadly explores gene regulatory mechanisms associated with susceptibility to atrial fibrillation-with key examples from both animal models and patients-within the context of both cardiac transcription factors and non-coding RNAs...
May 12, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29748196/interleukin-10-treatment-ameliorates-high-fat-diet-induced-inflammatory-atrial-remodeling-and-fibrillation
#7
(no author information available yet)
BACKGROUND: Obesity, characterized by systemic low-grade inflammation, is considered a well-known risk for atrial fibrillation. In fact, IL-10 (interleukin 10), which is a potent anti-inflammatory cytokine, has been reported to decrease in obese and diabetic patients. We tested the hypotheses forwarding that genetic deletion of IL-10 exacerbates high-fat diet (HFD)-induced obesity-caused atrial inflammation, lipidosis, fibrosis, and fibrillation and that IL-10 therapy inhibits this pathology...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29748195/does-high-intensity-endurance-training-increase-the-risk-of-atrial-fibrillation-a-longitudinal-study-of-left-atrial-structure-and-function
#8
Mildred A Opondo, Norman Aiad, Matthew A Cain, Satyam Sarma, Erin Howden, Douglas A Stoller, Jason Ng, Pieter van Rijckevorsel, Michinari Hieda, Takashi Tarumi, M Dean Palmer, Benjamin D Levine
BACKGROUND: Exercise mitigates many cardiovascular risk factors associated with atrial fibrillation. Endurance training has been associated with atrial structural changes which can increase the risk for atrial fibrillation. The dose of exercise training required for these changes is uncertain. We sought to evaluate the impact of exercise on left atrial (LA) mechanical and electrical function in healthy, sedentary, middle-aged adults. METHODS: Sixty-one adults (52±5 years) were randomized to either 10 months of high-intensity exercise training or yoga...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29744559/chronic-kidney-disease-induced-atrial-structural-remodeling-and-atrial-fibrillation-more-studies-on-the-pathological-mechanism-are-encouraged
#9
EDITORIAL
Huiliang Qiu, Chunlan Ji, Huanlin Wu, Chuan Zou
No abstract text is available yet for this article.
May 10, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29743409/impact-of-sinus-node-recovery-time-after-long-standing-atrial-fibrillation-termination-on-the-long-term-outcome-of-catheter-ablation
#10
Naoko Yamaguchi, Yasuo Okumura, Ichiro Watanabe, Koichi Nagashima, Keiko Takahashi, Kazuki Iso, Ryuta Watanabe, Masaru Arai, Hiroaki Mano, Rikitake Kogawa, Sayaka Kurokawa, Kimie Ohkubo, Toshiko Nakai, Atsushi Hirayama, Kazumasa Sonoda, Toshimasa Tosaka
Atrial electrical and structural remodeling is related to the perpetuation of atrial fibrillation (AF) subsequent to sinus node dysfunction. We investigated the relationship between AF recurrence after catheter ablation and sinus node dysfunction in long-standing persistent AF patients using the sinus node recovery time (SNRT) after defibrillation.Fifty-one consecutive patients who underwent a first ablation for long-standing persistent AF were enrolled. Intracardiac cardioversion was applied before ablation in the absence of any antiarrhythmic drugs, and the power required to defibrillate, number, and SNRT after defibrillation were measured...
May 9, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29731119/relation-of-left-atrial-appendage-remodeling-by-magnetic-resonance-imaging-and-outcome-of-ablation-for-atrial-fibrillation
#11
Promporn Suksaranjit, Nassir F Marrouche, Frederick T Han, Alan Morris, Gagandeep Kaur, Tyson Oswald, Brent D Wilson
The left atrial appendage (LAA) is a nonpulmonary vein trigger site in atrial fibrillation (AF). The association of LAA structural remodeling (SRM) identified by late gadolinium enhancement magnetic resonance imaging (LGE-MRI) and AF ablation outcome has never been described. This study sought to investigate the clinical significance of LAA-SRM in AF patients who undergo ablation therapy. Consecutive patients with AF who underwent catheter ablation therapy within 14 days following MRI scan were included in this study...
March 29, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29724595/effect-of-tricuspid-annuloplasty-concomitant-with-left-heart-surgery-on-right-heart-geometry-and-function
#12
Tomoki Sakata, Kenji Mogi, Manabu Sakurai, Anan Nomura, Masahiko Fujii, Daisuke Kaneyuki, Goro Matsumiya, Yoshiharu Takahara
OBJECTIVES: To elucidate the effect of tricuspid annuloplasty concomitant with left-sided valve surgery on the right heart in patients with mild or more tricuspid regurgitation (TR). METHODS: We enrolled 78 patients with mild or more TR who underwent left-sided valve surgery. Forty-three patients underwent only left-sided valve surgery (group non-T) and 35 underwent concomitant tricuspid annuloplasty (group T). Echocardiographic changes between the preoperative and 1-year follow-up periods were compared...
April 3, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29723239/analysis-of-the-microrna-signature-in-left-atrium-from-patients-with-valvular-heart-disease-reveals-their-implications-in-atrial-fibrillation
#13
Rosa Doñate Puertas, Audrey Jalabert, Emmanuelle Meugnier, Vanessa Euthine, Philippe Chevalier, Sophie Rome
BACKGROUND: Among the potential factors which may contribute to the development and perpetuation of atrial fibrillation, dysregulation of miRNAs has been suggested. Thus in this study, we have quantified the basal expressions of 662 mature human miRNAs in left atrium (LA) from patients undergoing cardiac surgery for valve repair, suffering or not from atrial fibrillation (AF) by using TaqMan® Low Density arrays (v2.0). RESULTS: Among the 299 miRNAs expressed in all patients, 42 miRNAs had altered basal expressions in patients with AF...
2018: PloS One
https://www.readbyqxmd.com/read/29721673/linagliptin-prevents-atrial-electrical-and-structural-remodeling-in-a-canine-model-of-atrial-fibrillation
#14
Tazuru Igarashi, Shinichi Niwano, Hiroe Niwano, Tomoharu Yoshizawa, Hironori Nakamura, Hidehira Fukaya, Tamami Fujiishi, Naruya Ishizue, Akira Satoh, Jun Kishihara, Masami Murakami, Junya Ako
Dipeptidyl peptidase 4 (DPP-4) inhibitors have recently been reported to exhibit additional cardioprotective effects; however, their effect in atrial remodeling, such as in atrial fibrillation (AF), remains unclear. In this study, the effect of linagliptin on atrial electrical and structural remodeling was evaluated in a canine AF model. Sixteen beagle dogs with 3-week atrial rapid stimulation were divided into the linagliptin group (9 mg/kg/day, n = 8) and pacing control group (n = 8). Three additional dogs without rapid pacing were assigned into non-pacing group, which was used as sham in this study...
May 2, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29720500/xanthine-oxidase-inhibitor-allopurinol-prevents-oxidative-stress-mediated-atrial-remodeling-in-alloxan-induced-diabetes-mellitus-rabbits
#15
Yajuan Yang, Jianping Zhao, Jiuchun Qiu, Jian Li, Xue Liang, Zhiwei Zhang, Xiaowei Zhang, Huaying Fu, Panagiotis Korantzopoulos, Konstantinos P Letsas, Gary Tse, Guangping Li, Tong Liu
BACKGROUND: There are several mechanisms, including inflammation, oxidative stress and abnormal calcium homeostasis, involved in the pathogenesis of atrial fibrillation. In diabetes mellitus (DM), increased oxidative stress may be attributable to higher xanthine oxidase activity. In this study, we examined the relationship between oxidative stress and atrial electrical and structural remodeling, and calcium handling abnormalities, and the potential beneficial effects of the xanthine oxidase inhibitor allopurinol upon these pathological changes...
May 2, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29718529/impact-of-left-atrial-appendage-closure-on-cardiac-functional-and-structural-remodeling-a-difference-in-difference-analysis-of-propensity-score-matched-samples
#16
Quang Tan Phan, Seung-Yong Shin, Ik-Sung Cho, Wang-Soo Lee, Hoyoun Won, Saima Sharmin, Dong-Young Lee, Tae-Ho Kim, Chee-Jeong Kim, Sang-Wook Kim
BACKGROUND: Although the safety and efficacy of left atrial appendage (LAA) closure (LAAC) in nonvalvular atrial fibrillation (NVAF) patients have been well documented in randomized controlled trials and real-world experience, there are limited data in the literature about the impact of LAAC on cardiac remodeling. The aim of the study was to examine the impact of LAAC on cardiac functional and structural remodeling in NVAF patients. METHOD: s: Between March 2014 and November 2016, 47 NVAF patients who underwent LAAC were included in this study (LAAC group)...
May 2, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29709893/treatment-strategies-for-atrial-fibrillation-with-left-ventricular-systolic-dysfunction-meta-analysis
#17
Jinhee Ahn, Hyun Jung Kim, Jeong Cheon Choe, Jin Sup Park, Hye Won Lee, Jun-Hyok Oh, Jung Hyun Choi, Han Cheol Lee, Kwang Soo Cha, Taek Jong Hong, Young-Hoon Kim
BACKGROUND: Atrial fibrillation (AF) frequently coexists with heart failure (HF) with reduced ejection fraction (EF). This meta-analysis compared AF control strategies, that is, rhythm vs. rate, and catheter ablation (CA) vs. anti-arrhythmic drugs (AAD) in patients with AF combined with HF.Methods and Results:The MEDLINE, EMBASE, and CENTRAL databases were searched, and 13 articles from 11 randomized controlled trials with 5,256 patients were included in this meta-analysis. The outcomes were echocardiographic parameters (left ventricular EF, LVEF), left atrial (LA) size, and left ventricular end-systolic volume, LVESV), clinical outcomes (mortality, hospitalization, and thromboembolism), exercise capacity, and quality of life (QOL)...
April 27, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29706494/is-there-a-role-for-genes-in-exercise-induced-atrial-cardiomyopathy
#18
REVIEW
Diane Fatkin, Charles D Cox, Inken G Huttner, Boris Martinac
In endurance athletes, prolonged high intensity exercise participation can have deleterious effects on the myocardium with subsequent structural and electrical remodelling. In a subset of athletes, there is a predilection for atrial involvement and the risk of atrial fibrillation (AF) is increased. The mechanisms underpinning exercise-induced atrial cardiomyopathy have yet to be fully elucidated and the contribution of an individual's genetic makeup is unknown. Some athletes may have rare genetic variants that are sufficient to cause AF irrespective of exercise exposure...
April 9, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29703439/left-atrial-reverse-remodeling-after-catheter-ablation-of-nonparoxysmal-atrial-fibrillation-in-patients-with-heart-failure-with-reduced-ejection-fraction
#19
Takafumi Oka, Koichi Inoue, Koji Tanaka, Yuichi Ninomiya, Yuko Hirao, Nobuaki Tanaka, Masato Okada, Hiroyuki Inoue, Ryo Nakamaru, Yasushi Koyama, Atsunori Okamura, Katsuomi Iwakura, Yasushi Sakata, Kenshi Fujii
The efficacy of catheter ablation (CA) of nonparoxysmal atrial fibrillation (PAF) in patients with left ventricular systolic dysfunction is controversial. We investigated the outcomes of CA for non-PAF in patients with reduced left ventricular ejection fraction (LVEF) and the impact of early left atrial (LA) reverse remodeling on these outcomes. A total of 251 consecutive patients who underwent CA for non-PAF were divided into 2 groups (reduced: preoperative LVEF ≤55%, LVEF: 46.5 ± 8.7%, n = 63; normal: >55%, 65...
March 29, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29694647/atrial-fibrillation-and-hypertension-state-of-the-art
#20
Soufia Naccache, Mouna Ben Kilani, Rami Tlili, Youssef Ben Ameur, Mohamed Rachid Boujnah
Atrial fibrillation and hypertension are often coexistent. Their incidence increases with advancing age and they are responsible for considerable morbidity and mortality. The relation between theses 2 diseases has long been discussed and determined by clinical studies. Left ventricular hypertrophy and left atrial remodeling during hypertension favor the development of atrial fibrillation. AF during hypertension increases the risk of thromboembolic complications and heart failure. In patients with hypertension, pharmacological treatment may control the cardiac structural changes and retard or prevent the occurrence of atrial fibrillation...
July 2017: La Tunisie Médicale
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