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Atrial fibrillation and pericardial fat

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https://www.readbyqxmd.com/read/27666172/relation-of-pericardial-fat-intrathoracic-fat-and-abdominal-visceral-fat-with-incident-atrial-fibrillation-from-the-framingham-heart-study
#1
Jane J Lee, Xiaoyan Yin, Udo Hoffmann, Caroline S Fox, Emelia J Benjamin
Obesity is associated with increased risk of developing atrial fibrillation (AF). Different fat depots may have differential associations with cardiac pathology. We examined the longitudinal associations between pericardial, intrathoracic, and visceral fat with incident AF. We studied Framingham Heart Study Offspring and Third-Generation Cohorts who participated in the multidetector computed tomography substudy examination 1. We constructed multivariable-adjusted Cox proportional hazard models for risk of incident AF...
November 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27301329/pericardial-fat-is-associated-with-the-risk-of-ventricular-arrhythmia-in-asian-patients
#2
Weng-Chio Tam, Yung-Kuo Lin, Wing-Pong Chan, Jen-Hung Huang, Ming-Hsiung Hsieh, Shih-Ann Chen, Yi-Jen Chen
BACKGROUND: Pericardial fat is correlated with the occurrence of atrial fibrillation or coronary atherosclerosis. However, the role of pericardial fat in ventricular arrhythmia remains unclear. METHODS AND RESULTS: Patients who had undergone dual-source computed tomography and 24-h Holter ECG were retrospectively enrolled. Quantification of the volume of pericardial fat surrounding the ventricles was analyzed using threshold attenuation of dual-source CT. The volume of pericardial fat was significantly different among those without ventricular premature beats (VPBs) in 24 h (n=28), those with occasional VPBs (n=54) and those with frequent VPBs (n=34) (12...
July 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27249809/excessive-interatrial-adiposity-is-associated-with-left-atrial-remodeling-augmented-contractile-performance-in-asymptomatic-population
#3
Yau-Huei Lai, Chun-Ho Yun, Cheng-Huang Su, Fei-Shih Yang, Hung-I Yeh, Charles Jia-Yin Hou, Tung-Hsin Wu, Ricardo C Cury, Hiram G Bezerra, Chung-Lieh Hung
PURPOSE: Pericardial adipose tissue had been shown to exert local effects on adjacent cardiac structures. Data regarding the mechanistic link between such measures and left atrial (LA) structural/functional remodeling, a clinical hallmark of early stage heart failure (HF) and atrial fibrillation (AF) incidence, in asymptomatic population remain largely unexplored. METHODS: This retrospective analysis includes 356 subjects free from significant valvular disorders, atrial fibrillation, or clinical HF...
March 2016: Echo Research and Practice
https://www.readbyqxmd.com/read/26945264/hemopericardium-under-dabigatran-for-stroke-prevention-in-atrial-fibrillation
#4
Claudia Stöllberger, Maria Heger, Josef Finsterer
Spontaneous hemopericardium is a complication of anticoagulant therapy with not only vitamin-K-antagonists, but also with nonvitamin-K-antagonist oral anticoagulants. We report a polymorbid 75-year old male under a therapy with dabigatran, valsartan, amlodipine, nicorandil, furosemide, atorvastatin, bisoprolol, metformin, tizanidine, pantoprazole, and tramadol. He suffered from chest pain for 4 months. Coronary angiography showed only ectatic coronary arteries. He started taking nonsteroidal anti-inflammatory drugs...
March 4, 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/26837853/relationships-between-left-atrial-pericardial-fat-and-permanent-atrial-fibrillation-results-of-a-case-control-study
#5
D Sevinc, L Pasaoglu, R Coskun, N Atci, A Alimli
PURPOSE: The goal of this study was to retrospectively investigate the relationships between pericardial fat, left atrium volume (LAV) as measured on multidetector row computed tomography (MDCT) and persistent atrial fibrillation (AF) using a case-control study. MATERIALS AND METHODS: The study population consisted of 58 patients (19 men, 39 women; mean age, 67.8±10 [SD] years) with persistent AF and 74 control subjects (30 men, 44 women; mean age, 67.8±10.9 [SD] years)...
March 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/26025867/pericardial-fat-and-atrial-fibrillation-epidemiology-mechanisms-and-interventions
#6
REVIEW
Mohamed Al-Rawahi, Riccardo Proietti, George Thanassoulis
Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice and is associated with major morbidity and mortality. AF prevalence has been projected to increase in the coming decades and is expected to affect over 7.5 million Americans by the year 2050. There is growing evidence that obesity represents an important risk factor for new onset AF, with each increment in BMI associated with a 3-8% higher risk for new-onset of AF, independent of other conventional AF risk factors such as age, hypertension and heart failure...
September 15, 2015: International Journal of Cardiology
https://www.readbyqxmd.com/read/25956552/simultaneous-fat-and-bone-assessment-in-hospitalized-heart-failure-patients-using-non-contrast-enhanced-computed-tomography
#7
Masaaki Konishi, Eiichi Akiyama, Hiroyuki Suzuki, Noriaki Iwahashi, Nobuhiko Maejima, Kengo Tsukahara, Kiyoshi Hibi, Masami Kosuge, Toshiaki Ebina, Yasushi Matsuzawa, Satoshi Umemura, Kazuo Kimura
BACKGROUND: Heart failure (HF) is associated with adverse metabolic influences and provokes fat loss as well as bone and muscle loss at the terminal stages. Pericardial fat is an ectopic fat depot that can potentially affect the myocardium, but the role of pericardial fat in HF is unclear. We sought to characterize pericardial fat in HF, particularly in association with bone tissue using cardiac computed tomography (CT). METHODS: In 61 consecutive hospitalized HF patients with left ventricular ejection fraction ≤50%, pericardial fat volume (PFV), CT density in the thoracic vertebrae, and ectopic calcification in the aortic valve were assessed simultaneously using electrocardiogram-gated non-contrast-enhanced CT...
January 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/25929437/inflammation-a-link-between-obesity-and-atrial-fibrillation
#8
REVIEW
Alina Scridon, Dan Dobreanu, Philippe Chevalier, Răzvan Constantin Şerban
Despite the long belief that the role of the adipose tissue was restricted to that of a passive store of triglycerides and a rich source of fatty acids, accumulating data demonstrates that the adipose tissue acts as an endocrine organ, capable of producing a large number of cytokines incriminated in generating a systemic inflammatory status. At its turn, this adiposity-related pro-inflammatory status appears to promote a large range of cardiovascular disorders, including atrial fibrillation (AF). Recent studies suggest that, in addition to systemic adiposity, the volume of the pericardial fat of the entire heart, and particularly of that overlying the atria, may represent an even more important risk factor for AF...
June 2015: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/25770455/myocardial-fat-as-a-part-of-cardiac-visceral-adipose-tissue-physiological-and-pathophysiological-view
#9
REVIEW
K Selthofer-Relatić, I Bošnjak
Thoracic fat includes extra-pericardial (outside the visceral pericardium) and intra-pericardial (inside the visceral pericardium) adipose tissue. It is called ectopic adipose tissue although it is a normal anatomical structure. Intra-pericardial adipose tissue, which is predominantly composed of epicardial and pericoronary adipose tissue, has a significant role in cardiovascular system function. It provides metabolic-mechanical support to the heart and blood vessels in physiological conditions, while it represents metabolic-cardiovascular risk in case of qualitative and quantitative structural changes in the tissue: it correlates with coronary atherosclerotic disease, left ventricular mass, left atrium enlargement and atrial fibrillation presence...
September 2015: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/25176630/pericardial-fat-volume-is-associated-with-clinical-recurrence-after-catheter-ablation-for-persistent-atrial-fibrillation-but-not-paroxysmal-atrial-fibrillation-an-analysis-of-over-600-patients
#10
Tae-Hoon Kim, Junbeom Park, Jin-Kyu Park, Jae-Sun Uhm, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
BACKGROUND: Although pericardial fat volume (PFV) has been suggested to be associated with atrial fibrillation (AF), only a few studies have reported the association between pericardial fat and clinical outcome after radiofrequency catheter ablation (RFCA). The purpose of this study was to explore the factors associated with PFV and its prognostic significance after catheter ablation for AF, depending on the types of AF. METHODS: We included 665 patients (76.7% male, 57...
October 20, 2014: International Journal of Cardiology
https://www.readbyqxmd.com/read/24834998/importance-of-pericardial-fat-in-the-formation-of-complex-fractionated-atrial-electrogram-region-in-atrial-fibrillation
#11
Hisanori Kanazawa, Hiroshige Yamabe, Koji Enomoto, Junjiroh Koyama, Kenji Morihisa, Tadashi Hoshiyama, Kunihiko Matsui, Hisao Ogawa
BACKGROUND/OBJECTIVES: Pericardial fat (PF) and complex fractionated atrial electrogram (CFAE) are both associated with atrial fibrillation (AF). Therefore, we examined the relation between PF and CFAE area in AF. METHODS: The study population included 120 control patients without AF and 120 patients with AF (80 paroxysmal AF and 40 persistent AF) who underwent catheter ablation. Total cardiac PF volume, representing all adipose tissue within the pericardial sac, was measured by contrast-enhanced computed tomography...
July 1, 2014: International Journal of Cardiology
https://www.readbyqxmd.com/read/24763464/the-clinical-profile-and-pathophysiology-of-atrial-fibrillation-relationships-among-clinical-features-epidemiology-and-mechanisms
#12
REVIEW
Jason Andrade, Paul Khairy, Dobromir Dobrev, Stanley Nattel
Atrial fibrillation (AF) is the most common arrhythmia (estimated lifetime risk, 22%-26%). The aim of this article is to review the clinical epidemiological features of AF and to relate them to underlying mechanisms. Long-established risk factors for AF include aging, male sex, hypertension, valve disease, left ventricular dysfunction, obesity, and alcohol consumption. Emerging risk factors include prehypertension, increased pulse pressure, obstructive sleep apnea, high-level physical training, diastolic dysfunction, predisposing gene variants, hypertrophic cardiomyopathy, and congenital heart disease...
April 25, 2014: Circulation Research
https://www.readbyqxmd.com/read/24652814/pericardial-fat-is-strongly-associated-with-atrial-fibrillation-after-coronary-artery-bypass-graft-surgery%C3%A2
#13
George Drossos, Charilaos-Panagiotis Koutsogiannidis, Olga Ananiadou, George Kapsas, Fotini Ampatzidou, Athanasios Madesis, Kalliopi Bismpa, Panagiotis Palladas, Labros Karagounis
OBJECTIVES: Recent evidence suggests that pericardial fat may represent an important risk factor for cardiovascular disease because of its unique properties and its proximity to cardiac structures. It has been reported that pericardial fat volume (PFV) is associated with atrial fibrillation (AF). The purpose of this study was to investigate the association between PFV and new-onset AF following coronary artery bypass graft surgery (CABG). METHODS: PFV was measured using computed tomography in 83 patients with coronary artery disease scheduled to undergo elective isolated on-pump CABG...
December 2014: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/24595189/pericardial-fat-is-associated-with-atrial-conduction-the-framingham-heart-study
#14
Daniel J Friedman, Na Wang, James B Meigs, Udo Hoffmann, Joseph M Massaro, Caroline S Fox, Jared W Magnani
BACKGROUND: Obesity is associated with altered atrial electrophysiology and a prominent risk factor for atrial fibrillation. Body mass index, the most widely used adiposity measure, has been related to atrial electrical remodeling. We tested the hypothesis that pericardial fat is independently associated with electrocardiographic measures of atrial conduction. METHODS AND RESULTS: We performed a cross-sectional analysis of 1946 Framingham Heart Study participants (45% women) to determine the relation between pericardial fat and atrial conduction as measured by P wave indices (PWI): PR interval, P wave duration (P-duration), P wave amplitude (P-amplitude), P wave area (P-area), and P wave terminal force (P-terminal)...
March 4, 2014: Journal of the American Heart Association
https://www.readbyqxmd.com/read/24498950/cardiovascular-magnetic-resonance-of-total-and-atrial-pericardial-adipose-tissue-a-validation-study-and-development-of-a-3-dimensional-pericardial-adipose-tissue-model
#15
Rajiv Mahajan, Pawel Kuklik, Suchi Grover, Anthony G Brooks, Christopher X Wong, Prashanthan Sanders, Joseph B Selvanayagam
BACKGROUND: Recently pericardial adipose tissue (PAT) has been shown to be an independent predictor of atrial fibrillation (AF). Atrial PAT may influence underlying atrial musculature creating a substrate for AF. This study sought to validate the assessment of total and atrial PAT by standard cardiovascular magnetic resonance (CMR) measures and describe and validate a three dimensional atrial PAT model. METHODS: 10 merino cross sheep underwent CMR using a 1.5 Tesla system (Siemens, Sonata, Erlangen, Germany)...
2013: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/24497517/association-of-epicardial-adipose-tissue-and-left-atrial-size-on-non-contrast-ct-with-atrial-fibrillation-the-heinz-nixdorf-recall-study
#16
Amir A Mahabadi, Nils Lehmann, Hagen Kälsch, Marcus Bauer, Iryna Dykun, Kaffer Kara, Susanne Moebus, Karl-Heinz Jöckel, Raimund Erbel, Stefan Möhlenkamp
AIMS: Epicardial adipose tissue (EAT) is increased in subjects with atrial fibrillation (AF). Likewise, EAT is associated with left atrial (LA) size, as itself is a strong predictor of AF. We aimed to determine the association of EAT and LA size as computed tomography (CT)-derived measures with prevalent and incident AF and investigated whether both measures independently predict AF. METHODS AND RESULTS: Participants from the Heinz Nixdorf Recall study without known cardiovascular disease were included...
August 2014: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/24282702/epicardial-and-thoracic-fat-noninvasive-measurement-and-clinical-implications
#17
Damini Dey, Ryo Nakazato, Debiao Li, Daniel S Berman
Epicardial fat, the local visceral fat depot enclosed by the visceral pericardial sac, surrounds the coronary arteries for most of their course, and may contribute to the development of coronary atherosclerosis through local production of inflammatory cytokines. Several studies which measured epicardial fat volume noninvasively have shown a relationship of increased epicardial fat volume with coronary artery disease, with the presence and progression of coronary plaque, major adverse cardiovascular events, myocardial ischemia and atrial fibrillation...
June 2012: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/23879190/obesity-and-atrial-fibrillation
#18
REVIEW
H S Abed, G A Wittert
Atrial fibrillation (AF) is an increasing public health problem, often described as the epidemic of the new millennium. The rising health economic impact of AF, its association with poor quality of life and independent probability of increased mortality, has recently been highlighted. Although population ageing is regarded as an important contributor to this epidemic, obesity and its associated cardiometabolic comorbidities may represent the principal driving factor behind the current and projected AF epidemic...
November 2013: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/23706446/the-role-of-cardiac-magnetic-resonance-imaging-in-the-evaluation-of-congenital-pericardial-defects
#19
Jennifer Tomich, Mohit Bhasin, Jonathan Philpott
Pericardial defects are rare congenital anomalies that result from failure of the pericardium to form properly during embryogenesis. In this article, we present a case of a patient with persistent atrial fibrillation who underwent a multimodality imaging evaluation that included cardiac magnetic resonance imaging. Our patient demonstrated secondary signs of a partial defect that was not directly visualized on imaging and was ultimately diagnosed during open surgical intervention. This case illustrates that a high level of suspicion should be maintained for patients who demonstrate secondary imaging findings that suggest the presence of an underlying pericardial defect...
June 2013: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/23584714/increased-pericardial-adipose-tissue-is-correlated-with-atrial-fibrillation-and-left-atrial-dilatation
#20
Martin Greif, Franz von Ziegler, Reza Wakili, Janine Tittus, Christoph Becker, Susanne Helbig, Ruediger P Laubender, Wolfgang Schwarz, Melvin D'Anastasi, Jan Schenzle, Alexander W Leber, Alexander Becker
INTRODUCTION: Pericardial adipose tissue (PAT), a visceral fat depot surrounding the heart, serves as an endocrine active organ and is associated with inflammation. There is growing evidence that atrial fibrillation (AF) is linked with inflammation, which in turn can be a promoter of left atrial remodeling. The aim of this study was to evaluate a potential correlation of PAT to AF and left atrial structural remodeling represented by LA size. METHODS: PAT was measured in 1,288 patients who underwent coronary artery calcium-scanning for coronary risk stratification...
August 2013: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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