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Atrial fibrillation and obesity

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https://www.readbyqxmd.com/read/29345382/overweight-and-obesity-in-patients-with-atrial-fibrillation-sex-differences-in-1-year-outcomes-in-the-eorp-af-general-pilot-registry
#1
Giuseppe Boriani, Cécile Laroche, Igor Diemberger, Elisa Fantecchi, Joan Meeder, Malgorzata Kurpesa, Monica Mariana Baluta, Marco Proietti, Luigi Tavazzi, Aldo P Maggioni, Gregory Y H Lip
BACKGROUND: The impact of overweight and obesity on outcomes in "real world" patients with atrial fibrillation (AF) is not fully defined. Second, sex differences in AF outcomes may also exist. METHODS AND RESULTS: The aim was to investigate outcomes at 1-year follow-up for AF patients enrolled in the EORP-AF Registry, according to BMI (kg/m2 ), comparing patients with normal BMI (18.5 to < 25 kg/m2), overweight (25 to < 30 kg/m2 ) and obesity (≥30 kg/m2 ), in relation to sex differences...
January 18, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29336970/a-nasal-ventilation-mask-for-a-morbidly-obese-patient-with-osa-and-atrial-fibrillation-undergoing-cardioversion
#2
Rachel Kozinn, James Kim, Lori Kwan, Jessica Feinleib
No abstract text is available yet for this article.
May 25, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29333506/murine-models-of-heart-failure-with-preserved-ejection-fraction-a-fishing-expedition
#3
Maria Valero-Muñoz, Warren Backman, Flora Sam
Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and symptoms of HF in the presence of a normal left ventricular (LV) ejection fraction (EF). Despite accounting for up to 50% of all clinical presentations of HF, the mechanisms implicated in HFpEF are poorly understood, thus precluding effective therapy. The pathophysiological heterogeneity in the HFpEF phenotype also contributes to this disease and likely to the absence of evidence-based therapies. Limited access to human samples and imperfect animal models that completely recapitulate the human HFpEF phenotype have impeded our understanding of the mechanistic underpinnings that exist in this disease...
December 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/29288262/rate-or-rhythm-control-of-atrial-fibrillation-pearls-for-the-internist
#4
Weiting Huang, Felix Yj Keng, Chi Keong Ching
Atrial fibrillation is an epidemic in Asia that is increasingly prevalent. Apart from stroke risk stratification and management of anticoagulation, physicians managing this group of patients also need to determine an optimal strategy in terms of rate or rhythm control. With new techniques of catheter ablation to maintain patients in sinus rhythm, patients with atrial fibrillation now have more options for treatment, on top of pharmacological methods. This paper aims to review the current evidence for rate and rhythm control in both general patients and subgroups of interest commonly encountered in clinical practices such as obesity, heart failure and thyroid disease...
November 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29284990/the-impact-of-risk-factors-and-comorbidities-on-the-incidence-of-atrial-fibrillation
#5
Nabil Naser, Mirza Dilic, Azra Durak, Mehmed Kulic, Esad Pepic, Elnur Smajic, Zumreta Kusljugic
Introduction: Atrial fibrillation (AF) is the most common form of cardiac arrhythmia in clinical practice and its prevalence increases with age. Patients who develop AF also have cardiovascular risk factors, structural heart disease, and comorbidities, all of which can increase mortality. AF causes a significant economic burden with the increasing trend in AF prevalence and hospitalizations. Research Objectives: The objective of our study is to evaluate the impact of the most common known risk factors on the incidence of atrial fibrillation as an important precursor of cardiac and cerebrovascular morbidity and mortality among our patients in Bosnia and Herzegovina during median follow up period (September 2006 - September 2016)...
December 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/29284569/epidemiology-of-stroke-in-costa-rica-a-7-year-hospital-based-acute-stroke-registry-of-1319-consecutive-patients
#6
Gabriel Torrealba-Acosta, Kenneth Carazo-Céspedes, Sy Han Chiou, Anthony Terrence O'Brien, Huberth Fernández-Morales
BACKGROUND: Limited data on stroke exist for Costa Rica. Therefore, we created a stroke registry out of patients with stroke seen in the Acute Stroke Unit of the Hospital Calderon Guardia. METHODS: We analyzed 1319 patients enrolled over a 7-year period, which incorporated demographic, clinical, laboratory, and neuroimaging data. RESULTS: The mean age of patients with stroke was 68.0 ± 15.5 years. Seven hundred twenty-five were men and the age range was 13-104 years...
December 25, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29276933/-restoration-of-sinus-rhythm-in-patients-with-persistent-atrial-fibrillation-and-obesity-new-possibilities-of-pharmacological-cardioversion
#7
S P Golitsyn, M A Saidova, S F Sokolov, V V Vlodzyanovskiy, T A Malkina, L V Rozenshtraukh, E I Chazov
We present in this article 2 cases of successful pharmacological restoration of sinus rhythm by a new class III antiarrhythmic drug refralon in patients with obesity and persistent atrial fibrillation. In both cases, the effective use of refralon was preceded by repeated ineffective attempts of electrical cardioversion. In the article we discuss the role of obesity as the factor leading to a substantial increase of transthoracic electrical resistance, and thus significantly reducing the probability of sinus rhythm restoration by means of electrical cardioversion...
October 2017: Kardiologiia
https://www.readbyqxmd.com/read/29223500/impact-of-chronic-kidney-disease-on-mortality-in-adults-undergoing-balloon-aortic-valvuloplasty
#8
Puja B Parikh, Samantha Novotny, Allen Jeremias, Javed Butler, Jie Yang, Donglei Yin, Luis Gruberg
BACKGROUND: Balloon aortic valvuloplasty (BAV) is often utilized as a bridge prior to surgical or transcatheter aortic valve replacement. Chronic kidney disease (CKD) is commonly present in patients with aortic stenosis, however, its association with outcomes following BAV has not been well studied. Accordingly, we sought to assess the impact of CKD on mortality in adults undergoing BAV. METHODS: The Nationwide Inpatient Sample was screened for hospitalizations involving adults undergoing BAV from 2006 to 2012...
October 26, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29221283/effectiveness-and-safety-of-simultaneous-hybrid-thoracoscopic-endocardial-catheter-ablation-of-atrial-fibrillation-in-obese-and-non-obese-patients
#9
Kevin Phan, Laurent Pison, Nelson Wang, Aran Kanagaratnam, Tristan D Yan, Bart Maesen, Jos G Maessen, Harry J Crijns, Mark La Meir
Background: We evaluated the safety and effectiveness of the hybrid thoracoscopic endocardial epicardial ablation technique for the treatment of atrial fibrillation (AF) in obese versus non-obese patients. Methods: Between January 2010 and January 2015, a cohort of 61 patients were retrospectively identified to undergo ablation of AF as a stand-alone procedure using a thoracoscopic, hybrid epicardial-endocardial technique. All patients underwent continuous 7-day Holter monitoring at 3, 6 months, 1 year and yearly thereafter...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29194845/weight-loss-in-obese-patients-with-longstanding-persistent-atrial-fibrillation-undergoing-catheter-ablation-is-it-worth-the-trouble
#10
EDITORIAL
Sanjay Dixit, Amaryah Yaeger
No abstract text is available yet for this article.
December 1, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29192873/incidence-of-first-stroke-and-ethnic-differences-in-stroke-pattern-in-bradford-uk-bradford-stroke-study
#11
Hawraman Ramadan, Chris Patterson, Stuart Maguire, Ian Melvin, Kirti Kain, Elizabeth Teale, Anne Forster
Background Information on ethnic disparities in stroke between White and Pakistani population in Europe is scarce. Bradford District has the largest proportion of Pakistani people in England; this provides a unique opportunity to study the difference in stroke between the two major ethnic groups. Aim To determine the first-ever-stroke incidence and examine the disparities in stroke patterns between Whites and Pakistanis in Bradford. Methods Prospective 12 months study consisting of 273,327 adults (≥18 years) residents...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29191806/atrial-fibrillation-prevention-an-appraisal-of-current-evidence
#12
REVIEW
Giuseppe Boriani, Marco Proietti
Atrial fibrillation (AF), which is the most diagnosed arrhythmia, is becoming a significant issue for health policy-makers. In particular, more and more attention is being devoted to AF prevention. Indeed, several studies recently published point out how targeted interventions could be useful in reducing the risk of AF occurrence (or recurrence). In this review, we briefly summarised the role of the major risk factors associated with the incidence of AF, as well as the effectiveness of interventions aimed at controlling these risk factors...
November 30, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29190573/common-comorbidities-and-survival-in-ms-risk-for-stroke-type-1-diabetes-and-infections
#13
A Murtonen, S Kurki, K Hänninen, M Soilu-Hänninen, M-L Sumelahti
BACKGROUND: Survival in MS has increased during the era of disease modifying therapies, but life expectancy in MS patients is still reduced by several years. Increased risk for common comorbidities related to brain health, such as risk for circulatory diseases have been reported in MS and could affect survival. In this paper, we studied age- and gender adjusted risks for circulatory diseases and related disorders, and their impact on overall MS survival in population of Southwest Finland...
November 13, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29188871/impact-of-age-on-the-association-between-body-mass-index-and-all-cause-mortality-in-patients-with-atrial-fibrillation
#14
S Wu, Y M Yang, J Zhu, H B Wan, J Wang, H Zhang, X H Shao
OBJECTIVES: To explore the impact of age on the association between body mass index (BMI) and all-cause mortality in patients with atrial fibrillation (AF). METHODS: A total of 1991 patients with AF (69 ± 13 years, 54.9% female) were divided into three age groups: < 65 years, 65-75 years, and > 75 years, and followed for one year. The primary outcome was defined as all-cause mortality, with secondary outcomes including thromboembolism and major bleeding. Cox regression models were utilized to estimate hazard ratios (HRs) and 95% confidence intervals (CIs)...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29179200/stress-kinase-regulation-of-task-1-and-task-3
#15
Susanne Rinné, Aytug K Kiper, Constanze Schmidt, Beatriz Ortiz-Bonnin, Simone Zwiener, Guiscard Seebohm, Niels Decher
BACKGROUND/AIMS: TASK channels belong to the two-pore-domain potassium (K2P) channel family. TASK-1 is discussed to contribute to chronic atrial fibrillation (AFib) and has been together with uncoupling protein 1 found as a marker protein of brown adipose tissue (BAT) fat. In addition, TASK-1 was linked in a genome-wide association study to an increased body mass index. A recent study showed that TASK-1 inhibition is causing obesity in mice by a BAT whitening and that these effects are linked to the mineralocorticoid receptor pathway, albeit the mechanism remained elusive...
November 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29171116/impact-of-weight-loss-on-ablation-outcome-in-obese-patients-with-longstanding-persistent-atrial-fibrillation
#16
Sanghamitra Mohanty, Prasant Mohanty, Veronica Natale, Chintan Trivedi, Carola Gianni, J David Burkhardt, Javier E Sanchez, Rodney Horton, G Joseph Gallinghouse, Richard Hongo, Salwa Beheiry, Amin Al-Ahmad, Luigi Di Biase, Andrea Natale
AIMS: This study investigated the impact of weight loss in longstanding persistent (LSPAF) patients undergoing catheter ablation (CA). METHODS: Ninety consecutive obese LSPAF patients were approached; 58 volunteered to try weight loss interventions for up to 1 year (Group 1), while 32 patients declined weight loss interventions and were included as a control (Group 2). Both groups remained on antiarrhythmic drugs. If they continued to experience AF, CA was performed...
November 24, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29144513/predictors-of-heart-rhythm-disturbances-in-hypertensive-obese-patients-with-obstructive-sleep-apnea
#17
Lyudmila Sergeevna Korostovtseva, Nadezhda Edvinovna Zvartau, Oxana Petrovna Rotar, Yurii Vladimirovich Sviryaev, Aleksandra Olegovna Konradi
Objective: To assess the incidence and predictors of heart rhythm and conduction disturbances in hypertensive obese patients with and without obstructive sleep apnea (OSA). Methods: This is an open, cohort, prospective study. Out of 493 screened patients, we selected 279 hypertensive, obese individuals without severe concomitant diseases: 75 patients without sleep-disordered breathing (non-SDB group), and 204 patients with OSA (OSA group). At baseline, all patients underwent examination, including ECG, Holter ECG monitoring, and sleep study...
September 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29136331/risk-factor-management-in-a-contemporary-australian-population-at-increased-cardiovascular-disease-risk
#18
D J Campbell, J M Coller, F F Gong, M McGrady, D L Prior, U Boffa, L Shiel, D Liew, R Wolfe, A J Owen, H Krum, C M Reid
BACKGROUND: Effective management of cardiovascular and chronic kidney disease risk factors offers longer, healthier lives and savings in health care. We examined risk factor management in participants of the SCReening Evaluation of the Evolution of New Heart Failure (SCREEN-HF) study, a self-selected population at increased cardiovascular disease risk recruited from members of a health insurance fund in Melbourne and Shepparton, Australia. METHODS: Inclusion criteria were age ≥60 years with one or more of self-reported ischaemic or other heart disease, irregular or rapid heart rhythm, cerebrovascular disease, renal impairment, or treatment for hypertension or diabetes for ≥2 years...
November 14, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29131442/increased-rates-of-atrial-fibrillation-recurrence-following-pulmonary-vein-isolation-in-overweight-and-obese-patients
#19
Bhradeev Sivasambu, Muhammad A Balouch, Tarek Zghaib, Rizma J Bajwa, Jonathan Chrispin, Ronald D Berger, Hiroshi Ashikaga, Saman Nazarian, Joseph E Marine, Hugh Calkins, David D Spragg
INTRODUCTION: Catheter ablation is common for patients with symptomatic, drug-refractory atrial fibrillation (AF). Obesity is a known risk factor for incident AF. The impact of obesity on AF ablation outcomes is incompletely understood. We sought to determine the impact of elevated body mass index (BMI) on pulmonary vein isolation (PVI) procedural outcomes and associated complications. METHODS AND RESULTS: We evaluated patients undergoing PVI from 2001 to 2015, dividing them into four groups: normal weight (BMI ≥ 18...
November 13, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29126781/influence-of-abdominal-obesity-and-habitual-behaviors-on-incident-atrial-fibrillation-in-japanese
#20
Richiro Hamada, Jung Su Lee, Katsumi Mori, Etsuko Watanabe, Shigeki Muto
BACKGROUND: As atrial fibrillation (AF) increases with the aging of the population, it is urgently required to clarify modifiable factors to prevent AF. However, evidence regarding the independent influence of abdominal-obesity and habitual behaviors on incident AF is limited among Japanese. METHODS AND RESULTS: Those aged 40-79 years undergoing periodic health checkups during 2008-2014 were followed-up in 2015 (n=96,841) and the independent risk of incident AF was estimated using multivariate Cox proportional hazards regression models after adjustment for potential covariates...
November 7, 2017: Journal of Cardiology
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