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Atrial fibrillation and obesity

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https://www.readbyqxmd.com/read/28229164/are-cardiovascular-risk-factors-also-associated-with-the-incidence-of-atrial-fibrillation-a-systematic-review-and-field-synopsis-of-23-factors-in-32-population-based-cohorts-of-20-million-participants
#1
Victoria Allan, Shohreh Honarbakhsh, Juan-Pablo Casas, Joshua Wallace, Ross Hunter, Richard Schilling, Pablo Perel, Katherine Morley, Amitava Banerjee, Harry Hemingway
Established primary prevention strategies of cardiovascular diseases are based on understanding of risk factors, but whether the same risk factors are associated with atrial fibrillation (AF) remains unclear. We conducted a systematic review and field synopsis of the associations of 23 cardiovascular risk factors and incident AF, which included 84 reports based on 28 consented and four electronic health record cohorts of 20,420,175 participants and 576,602 AF events. We identified 3-19 reports per risk factor and heterogeneity in AF definition, quality of reporting, and adjustment...
February 23, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28215267/a-community-based-study-of-risk-factors-for-probable-rapid-eye-movement-sleep-behavior-disorder
#2
Jian-Fang Ma, Yuan Qiao, Xiang Gao, Liang Liang, Xiao-Li Liu, Dun-Hui Li, Hui-Dong Tang, Sheng-Di Chen
OBJECTIVES: To cross-sectionally explore the potential risk factors for rapid eye movement (REM) sleep behavior disorder (RBD) in a community cohort in Shanghai. METHODS: Based on the validated RBD screening questionnaire (RBDSQ), we identified individuals with probable RBD (pRBD) in 3635 community-dwelling residents (≥50 years old) from an urban community of Shanghai. Potential risk factors of pRBD, including age, sex, smoking, socioeconomic status, obesity, consumption of tea (surrogate for caffeine intake) and alcohol, medications and chronic disease status, were assessed via questionnaire...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28196797/left-atrial-structure-in-relationship-to-age-sex-ethnicity-and-cardiovascular-risk-factors-mesa-multi-ethnic-study-of-atherosclerosis
#3
Filip Zemrak, Bharath Ambale-Venkatesh, Gabriella Captur, Jonathan Chrispin, Ela Chamera, Mohammadali Habibi, Saman Nazarian, Saidi A Mohiddin, James C Moon, Steffen E Petersen, João A C Lima, David A Bluemke
BACKGROUND: Left atrial (LA) size is a marker of diastolic function and is associated with atrial fibrillation and cardiovascular outcomes. However, there are no large population studies measuring LA structure. The relationship of demographics and cardiovascular risk factors to LA size is largely unknown. This study aimed to determine associations of LA size with demographic factors, cardiac structure and function, and cardiovascular risk factors. METHODS AND RESULTS: LA volume indexed to body surface area was measured by cardiovascular magnetic resonance steady-state free precession and fast gradient echo cine long- and short-axis images in 2576 asymptomatic participants of MESA ([Multi-Ethnic Study of Atherosclerosis] 68...
February 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28196379/pulmonary-embolism-and-atrial-fibrillation-two-sides-of-the-same-coin-a-systematic-review
#4
Behnood Bikdeli, Maen D Abou Ziki, Gregory Y H Lip
Pulmonary embolism (PE) is a common, potentially fatal thrombotic disease. Atrial fibrillation (AF), the most common arrhythmia, may also lead to thromboembolic complications. Although initially appearing as distinct entities, PE and AF may coexist. The direction and extent of this association has not been well characterized. We performed a search of PubMed, Scopus, and the Cochrane Database of Systematic Reviews for publications that reported coexisting AF in patients with PE, or vice versa, to provide a systematic overview of pathophysiological and epidemiological aspects of this association (last search: October 13, 2016)...
February 14, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28191907/anthropometric-parameters-and-the-incidence-of-atrial-fibrillation-in-older-people-the-pro-v-a-study
#5
Caterina Trevisan, Stefania Maggi, Chiara Curreri, Giovanni Nante, Marianna Noale, Marina De Rui, Egle Perissinotto, Leonardo Sartori, Sabina Zambon, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi
BACKGROUND: Atrial fibrillation (AF) has been associated with body size and central obesity, but the impact of different anthropometric measures in this relationship has been inadequately investigated. HYPOTHESIS: In this study, we examined the association between baseline anthropometric parameters with the incidence of AF in older people, hypothesizing that body size could impact the onset of AF more than fat distribution. METHODS: Our study included 1764 participants with a mean age of 74...
February 13, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28179605/the-effects-of-different-bmi-on-blood-loss-and-transfusions-in-chinese-patients-undergoing-coronary-artery-bypass-grafting
#6
Mingya Wang, Ming Chen, Hushan Ao, Sipeng Chen, Zhifa Wang
OBJECTIVE: Blood loss is a predictor of outcomes after coronary artery bypass grafting (CABG). This study investigated the effects of body mass index (BMI) on blood loss, blood transfusion rate, and the variations in coagulation parameters of Chinese patients undergoing CABG. METHODS: A total of 1007 Chinese patients who consecutively underwent isolated, primary CABG at Fuwai Hospital from January 1, 2013 to December 31, 2013 were included in this study. They were categorized by BMI into <24 kg/m(2) (low and normal weight group), 24≤ BMI <28 kg/m(2) (overweight group), and BMI ≥28 kg/m(2) (obese group)...
February 8, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28174193/age-specific-trends-in-incidence-mortality-and-comorbidities-of-heart-failure-in-denmark-1995-2012
#7
Mia N Christiansen, Lars Køber, Peter Weeke, Ramachandran S Vasan, Jørgen L Jeppesen, J Gustav Smith, Gunnar H Gislason, Christian Torp-Pedersen, Charlotte Andersson
BACKGROUND: -The cumulative burden and importance of cardiovascular risk factors have changed over the last decades. Specifically, obesity rates have increased among younger people, whereas cardiovascular health has improved in the elderly. Little is known regarding how these changes have impacted the incidence and the mortality rates of heart failure. Therefore, we aimed to investigate the age-specific trends in the incidence and 1-year mortality rates following a first time diagnosis of heart failure in Denmark between 1995 and 2012...
February 7, 2017: Circulation
https://www.readbyqxmd.com/read/28163048/heart-failure-with-preserved-ejection-fraction-diagnosis-and-management
#8
REVIEW
Ohad Oren, Sheldon Goldberg
Heart Failure with Preserved Ejection Fraction (HFpEF) is a prevalent condition with substantial individual and societal burden. Elucidation of the mechanisms of HFpEF is not complete. Recently, intriguing theories about the phenotypic importance of HFpEF (i.e. underlying diabetes mellitus, atrial fibrillation, obesity) have been suggested. However, it has yet to be determined if a targeted approach of that kind would help ameliorate symptoms or slow disease progression. In this article, we review the current status of understanding of HFpEF, focusing on the challenges and uncertainties regarding diagnosis and treatment...
February 2, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28139384/comorbidity-effects-on-shoulder-arthroplasty-costs-analysis-of-a-nationwide-private-payer-insurance-data-set
#9
Samuel Rosas, Karim G Sabeh, Leonard T Buller, Tsun Yee Law, Steven P Kalandiak, Jonathan C Levy
BACKGROUND: The purpose of this study was to evaluate the effect of common medical comorbidities on the reimbursements of different shoulder arthroplasty procedures. METHODS: We conducted a retrospective query of a single private payer insurance claims database using PearlDiver (Warsaw, IN, USA) from 2010 to 2014. Our search included the Current Procedural Terminology codes and International Classification of Diseases, Ninth Revision codes for total shoulder arthroplasty (TSA), hemiarthroplasty, and reverse shoulder arthroplasty (RSA)...
January 27, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28126153/poor-heart-rate-recovery-is-associated-with-the-development-of-new-onset-atrial-fibrillation-in-middle-aged-adults
#10
Avi Sabbag, Anat Berkovitch, Yechezkel Sidi, Shaye Kivity, Sagit Ben Zekry, Roy Beinart, Shlomo Segev, Michael Glikson, Ilan Goldenberg, Elad Maor
OBJECTIVE: To investigate the association between heart rate recovery (HRR) and new-onset atrial fibrillation (AF) in middle-aged adults. PATIENTS AND METHODS: Heart rate recovery was calculated using the exercise stress test in 15,729 apparently healthy self-referred men and women who attended periodic health screening examinations between January 2000, and December 2015. All participants completed the maximal exercise stress test according to the Bruce protocol and were followed clinically on a yearly basis for a median of 6...
December 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28119130/no-decline-in-the-risk-of-heart-failure-following-incident-atrial-fibrillation-a-community-study-assessing-trends-overall-and-by-ejection-fraction
#11
Alanna M Chamberlain, Bernard J Gersh, Alvaro Alonso, Stephen L Kopecky, Jill M Killian, Susan A Weston, Véronique L Roger
BACKGROUND: Patients with atrial fibrillation (AF) experience an increased risk of heart failure (HF). However, data are lacking on current trends in the risk of HF after AF. OBJECTIVE: To describe the temporal trends in HF occurrence after AF in a community cohort of patients with incident AF from 2000-2013. METHODS: Cox regression examined the association of year of AF diagnosis with HF and the predictors of developing HF after AF. RESULTS: Among 3491 AF patients without prior HF, 750 (21%) developed incident HF over a mean follow-up of 3...
January 21, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28107569/use-of-higher-maximum-doses-and-infusion-rates-compared-with-those-used-in-standard-unfractionated-heparin-therapy-is-associated-with-adequate-anticoagulation-without-increased-bleeding-in-both-obese-and-nonobese-patients-with-cardiovascular-indications
#12
Catherine K Floroff, Nicole M Palm, Daniel H Steinberg, Eric R Powers, Barbara S Wiggins
STUDY OBJECTIVE: To evaluate the time to achieve therapeutic activated partial thromboplastin time (aPTT) values and occurrence of bleeding based on standard unfractionated heparin (UFH) weight-based dosing recommendations compared with an aggressive weight-based UFH dosing strategy using higher maximum doses and infusion rates in both obese and nonobese patients who presented with non-ST-Segment Elevation Myocardial Infarction or unstable angina (NSTEMI/UA) or atrial fibrillation. DESIGN: Retrospective cohort study...
January 20, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28102478/influence-of-inflammation-and-atherosclerosis-in-atrial-fibrillation
#13
REVIEW
Rose Mary Ferreira Lisboa da Silva
BACKGROUND: Inflammation markers have been associated with cardiovascular diseases including atrial fibrillation. This arrhythmia is the most frequent, with an incidence of 38/1000 person-years. PURPOSE OF REVIEW: The aims of this study are to discuss the association between inflammation, atherosclerosis and atrial fibrillation and its clinical implications. Atherosclerosis is a chronic inflammatory disease and inflammation is a triggering factor of atherosclerotic plaque rupture...
January 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28062619/beyond-natriuretic-peptides-for-diagnosis-and-management-of-heart-failure
#14
REVIEW
Nasrien E Ibrahim, James L Januzzi
BACKGROUND: Heart failure (HF) is a complex syndrome with an enormous societal burden in terms of cost and morbidity and mortality. Natriuretic peptide (NP) testing is now widely used to support diagnosis, prognostication, and management of patients with HF, but NPs come with limitations, including vulnerability to the presence of obesity, atrial fibrillation, and renal dysfunction, for example. Beyond the NPs, novel biomarkers may supplement traditional clinical and laboratory testing to improve understanding of the complex disease process of HF, and possibly to personalize care for those affected through better individual phenotyping...
January 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28042092/increased-risk-of-major-bleeding-in-underweight-patients-with-atrial-fibrillation-who-were-prescribed-non-vitamin-k-antagonist-oral-anticoagulants
#15
Chan Soon Park, Eue-Keun Choi, Hyue Mee Kim, So-Ryoung Lee, Myung-Jin Cha, Seil Oh
BACKGROUND: There is a paucity of evidence regarding the effects of non-vitamin K antagonist oral anticoagulants (NOACs) in underweight patients with atrial fibrillation (AF). OBJECTIVE: The purpose of this study was to evaluate the efficacy and safety of NOACs in underweight AF patients. METHODS: We analyzed 1353 AF patients who were prescribed NOACs according to their body mass index (BMI): underweight (UW: n = 62, BMI <18.5 kg/m(2)), normal weight (NW: n = 753, BMI 18...
December 29, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28017937/catheter-ablation-of-atrial-fibrillation-in-very-young-adults-a-5-year-follow-up-study
#16
Ardan M Saguner, Tilman Maurer, Erik Wissner, Francesco Santoro, Christine Lemes, Shibu Mathew, Christian Sohns, Christian H Heeger, Bruno Reißmann, Johannes Riedl, Thomas Fink, Kentaro Hayashi, Peter Wohlmuth, Karl-Heinz Kuck, Feifan Ouyang, Andreas Metzner
AIMS: Catheter ablation is an established therapy for symptomatic atrial fibrillation (AF). However, outcome data on catheter ablation for AF in young adults is scarce. METHODS AND RESULTS: From 2005-2014, 85 consecutive young adults (mean age 31 ± 4 years; 69% men) with symptomatic paroxysmal AF (PAF, n = 52) and persistent (Pers) AF (n = 33) underwent pulmonary vein isolation (PVI) [±ablation of complex fractionated atrial electrograms/linear lesions in PVI non-responders] at our centre...
December 25, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28005263/does-early-onset-cataract-increase-the-risk-of-ischemic-stroke-a-nationwide-retrospective-cohort-study
#17
Chih-Yang Huang, Tung-Sheng Chen, Cheng-Li Lin, Wei-Syun Hu
This study was attempted to address the association between early onset cataract (EOC) and ischemic stroke. Using the Longitudinal Health Insurance Database 2000, we established an EOC cohort and a comparison cohort by using 4-fold propensity score matching according to age, gender and comorbidities to detect the incidence of ischemic stroke. A Cox model was used to express the risk of ischemic stroke for the EOC patients compared with the comparison cohort. After adjusting for age, gender and comorbidities of hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, asthma, chronic obstructive pulmonary disease, chronic kidney disease, heart failure, obesity, and atrial fibrillation, the EOC patients had a 1...
December 22, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27995601/the-associations-between-atrial-fibrillation-and-parameters-of-nutritional-status-assessment-in-the-general-hospital-population-a-cross-sectional-analysis-of-medical-documentation
#18
Jacek Budzyński, Marzena Anaszewicz
BACKGROUND: Atrial fibrillation (AF) and nutrition status abnormalities are two of the most significant epidemics in current health care. AIM: The aim of this study was to determine the relationships between a prevalence and outcome of AF, and parameters of nutritional status among consecutive, real-life patients hospitalized in a university hospital. METHODS: Analysis of the medical documentation of 4 930 consecutive patients aged ≥ 18 years hospitalized for more than one day with diagnoses of cardiovascular disorders...
December 20, 2016: Kardiologia Polska
https://www.readbyqxmd.com/read/27994598/matrix-metalloproteinase-neutrophil-gelatinase-associated-lipocalin-complex-predicts-atrial-fibrillation-recurrence-after-electrical-cardioversion-in-obese-patients
#19
Elzbieta Mlodawska, Anna Tomaszuk-Kazberuk, Paulina Lopatowska, Ewa Waszkiewicz, Hanna Bachorzewska-Gajewska, Jolanta Malyszko, Ewelina Michniewicz, Slawomir Dobrzycki, Wlodzimierz Jerzy Musial
BACKGROUND: There is not much data on matrix metalloproteinase neutrophil gelatinase-associated lipocalin (MMP-NGAL) complex in patients with atrial fibrillation (AF). AIM: The aim of the study was to assess the value of MMP-NGAL complex in predicting AF recurrence after electrical cardioversion. METHODS: The serum levels of NGAL, cystatin C, interleukin-6, high-sensitivity C-reactive protein, copeptin, MMP-NGAL complex, matrix metalloproteinase 2, tissue inhibitor of metalloproteinase 1, Von Willebrand factor, B-type natriuretic peptide and the urinary level of NGAL were evaluated before cardioversion...
November 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27974350/genetic-obesity-and-the-risk-of-atrial-fibrillation-causal-estimates-from-mendelian-randomization
#20
Neal A Chatterjee, Franco Giulianini, Bastiaan Geelhoed, Kathryn L Lunetta, Jeffrey R Misialek, Maartje N Niemeijer, Michiel Rienstra, Lynda M Rose, Albert V Smith, Dan E Arking, Patrick T Ellinor, Jan Heeringa, Honghuang Lin, Steven A Lubitz, Elsayed Z Soliman, Niek Verweij, Alvaro Alonso, Emelia J Benjamin, Vilmundur Gudnason, Bruno H C Stricker, Pim Van Der Harst, Daniel I Chasman, Christine M Albert
BACKGROUND: Observational studies have identified an association between body mass index (BMI) and incident atrial fibrillation (AF). Inferring causality from observational studies, however, is subject to residual confounding, reverse causation, and bias. The primary objective of this study was to evaluate the causal association between BMI and AF by using genetic predictors of BMI. METHODS: We identified 51 646 individuals of European ancestry without AF at baseline from 7 prospective population-based cohorts initiated between 1987 and 2002 in the United States, Iceland, and the Netherlands with incident AF ascertained between 1987 and 2012...
February 21, 2017: Circulation
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