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https://www.readbyqxmd.com/read/28105657/a-nomogram-to-predict-distant-metastasis-after-neoadjuvant-chemoradiotherapy-and-radical-surgery-in-patients-with-locally-advanced-rectal-cancer
#1
Yanwu Sun, Huiming Lin, Xingrong Lu, Ying Huang, Zongbin Xu, Shenghui Huang, Xiaojie Wang, Pan Chi
PURPOSE: To compare distant metastasis (DM) in locally advanced rectal cancer (LARC) patients treated with neoadjuvant chemoradiotherapy (nCRT) and surgery alone, and to develop a predictive nomogram for DM following nCRT. METHODS: Propensity-scoring match analysis was performed to compare DM in LARC treated with nCRT (n = 375) and surgery alone (n = 375). Cox regression was performed to identify predictors of DM following nCRT. A nomogram was developed and validated by internal (n = 425) and external validation (n = 97)...
January 20, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28103579/the-combination-of-early-treatment-response-and-ypt-stage-is-a-novel-metric-to-stage-rectal-cancer-patients-treated-with-neoadjuvant-chemoradiotherapy
#2
Jian Cui, Lin Yang, Lei Guo, Yongfu Shao, Dongfeng Tan, Ni Li, Haizeng Zhang
Rectal cancer patients receiving neoadjuvant chemoradiotherapy (NCRT) are currently classified using the same Tumor-Node-Metastasis staging system as those patients without NCRT. We determined whether the combination of tumor treatment response (TRG) and ypT stage more accurately assesses primary tumors in rectal cancer after NCRT. We analyzed data from 329 rectal cancer patients treated with NCRT followed by radical resection. Cox proportional hazards models were used to evaluate the effects of different staging parameters on disease-free survival (DFS)...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28100902/prognostic-role-of-neutrophil-to-lymphocyte-ratio-in-locally-advanced-rectal-cancer-treated-with-neoadjuvant-chemoradiotherapy
#3
Jinwen Shen, Yuan Zhu, Wei Wu, Lingnan Zhang, Haixing Ju, Yongtian Fan, Yuping Zhu, Jialin Luo, Peng Liu, Ning Zhou, Ke Lu, Na Zhang, Dechuan Li, Luying Liu
BACKGROUND Increasing evidence suggests that cancer-associated inflammation is associated with poorer outcomes. The neutrophil-to-lymphocyte ratio (NLR), considered as a systemic inflammation marker, is thought to predict prognoses in colorectal cancer. In this study, we explored the association between the NLR and prognoses following neoadjuvant chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). MATERIAL AND METHODS From February 2002 to December 2012, a group of 202 patients diagnosed with LARC and receiving neoadjuvant CRT followed by radical surgery was included in our retrospective study...
January 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28099105/quantitative-assessment-of-rectal-cancer-response-to-neoadjuvant-combined-chemotherapy-and-radiation-therapy-comparison-of-three-methods-of-positioning-region-of-interest-for-adc-measurements-at-diffusion-weighted-mr-imaging
#4
https://www.readbyqxmd.com/read/28099099/quantitative-assessment-of-rectal-cancer-response-to-neoadjuvant-combined-chemotherapy-and-radiation-therapy
#5
Ivana M Blazic, Gordana B Lilic, Milan M Gajic
No abstract text is available yet for this article.
February 2017: Radiology
https://www.readbyqxmd.com/read/28099070/laparoscopic-rectal-dissection-assisted-by-transanal-endoluminal-videoendoscopy-through-a-blunt-tip-trocar
#6
Emanuele Asti, Andrea Lovece, Luigi Bonavina
BACKGROUND AND AIMS: Laparoscopic resection is a well-established approach for colorectal cancer surgery. In patients with rectal cancer treated by neoadjuvant chemoradiotherapy, it may be difficult to identify a clear safety margin for endostapling and subsequent anastomosis. We designed an innovative technical approach to assist colorectal anastomosis in these patients. TECHNIQUE: A four-trocar laparoscopic approach is used. After exploration of the abdominal cavity, the left colic flexure is completely mobilized...
January 18, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28089690/mri-evaluation-of-rectal-cancer-staging-and-restaging
#7
REVIEW
Courtney C Moreno, Patrick S Sullivan, Pardeep K Mittal
Magnetic resonance imaging (MRI) plays an important role in the staging and restaging of rectal cancer. Multiplanar high-resolution (≤3-mm section thickness) T2-weighted images are the primary sequences used for rectal cancer staging. No preprocedural bowel cleansing regimen, intravenous contrast material, nor endorectal coil is necessary. MRI is highly accurate for differentiating T1-T2 disease from T3 and T4 disease, an important distinction as patients with T3 and T4 tumors typically undergo preoperative neoadjuvant chemoradiation before resection...
November 21, 2016: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28079398/feasibility-evaluation-of-diffusion-weighted-imaging-using-an-integrated-mri-radiotherapy-system-for-response-assessment-to-neoadjuvant-therapy-in-rectal-cancer
#8
Narek Shaverdian, Yingli Yang, Peng Hu, Steven Hart, Ke Sheng, James Lamb, Minsong Cao, Nzhde Agazaryan, David Thomas, Michael Steinberg, Daniel A Low, Percy Lee
OBJECTIVES: To evaluate the feasibility of on-board DWI with an integrated low-field MRI-radiotherapy system to assess responses to neoadjuvant chemoradiation (NAC) in rectal cancer. METHODS: A spin echo-based planar imaging diffusion sequence on a 0.35 T MRI-radiotherapy system was acquired over the course of NAC. The apparent diffusion coefficients (ADC) from the tumor region of interest (ROIs) were calculated. A functional diffusion map (fDM) was created showing a pixel-wise ADC analysis of the ROI over the course of treatment...
January 12, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28078118/less-than-12-lymph-nodes-in-the-surgical-specimen-after-neoadjuvant-chemo-radiotherapy-an-indicator-of-tumor-regression-in-locally-advanced-rectal-cancer
#9
Jaiprakash Gurawalia, Kapil Dev, Sandeep P Nayak, Vishnu Kurpad, Arun Pandey
BACKGROUND: The number of lymph node retrieved in the surgical specimen is important for tumor staging and has paramount impact on prognosis in colorectal cancer and imitates the adequacy of lymph node surgical clearance. The paucity of lymph node yields in patients undergoing resection after preoperative chemo radiotherapy (CRT) in rectal cancer has seen. Lower total number of lymph nodes in the total mesoractal excision (TME) specimen after CRT, could a marker of better tumor response...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28068245/ku70-ku80-and-sclusterin-a-cluster-of-predicting-factors-for-response-to-neoadjuvant-chemoradiation-therapy-in-patients-with-locally-advanced-rectal-cancer
#10
Sabina Pucci, Chiara Polidoro, Alessandro Joubert, Francesca Mastrangeli, Barbara Tolu, Michaela Benassi, Valeria Fiaschetti, Laura Greco, Roberto Miceli, Roberto Floris, Giuseppe Novelli, Augusto Orlandi, Riccardo Santoni
PURPOSE: The identification of predictive biomarkers for neoadjuvant chemoradiation therapy (CRT) is a current clinical need. The heterodimer Ku70/80 plays a critical role in DNA repair and cell death induction after damage. The aberrant expression and localization of these proteins fail to control DNA repair and apoptosis. sClusterin is the Ku70 partner that sterically inhibits Bax-dependent cell death after damage in some pathologic conditions. This study sought to evaluate the molecular relevance of Ku70-Ku80-Clu as a molecular cluster predicting the response to neoadjuvant CRT in patients with locally advanced rectal cancer (LARC)...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28060889/sequential-pet-ct-with-18f-fdg-predicts-pathological-tumor-response-to-preoperative-short-course-radiotherapy-with-delayed-surgery-in-patients-with-locally-advanced-rectal-cancer-using-logistic-regression-analysis
#11
Biagio Pecori, Secondo Lastoria, Corradina Caracò, Marco Celentani, Fabiana Tatangelo, Antonio Avallone, Daniela Rega, Giampaolo De Palma, Maria Mormile, Alfredo Budillon, Paolo Muto, Francesco Bianco, Luigi Aloj, Antonella Petrillo, Paolo Delrio
: Previous studies indicate that FDG PET/CT may predict pathological response in patients undergoing neoadjuvant chemo-radiotherapy for locally advanced rectal cancer (LARC). Aim of the current study is evaluate if pathological response can be similarly predicted in LARC patients after short course radiation therapy alone. METHODS: Thirty-three patients with cT2-3, N0-2, M0 rectal adenocarcinoma treated with hypo fractionated short course neoadjuvant RT (5x5 Gy) with delayed surgery (SCRTDS) were prospectively studied...
2017: PloS One
https://www.readbyqxmd.com/read/28059920/local-excision-techniques-for-rectal-cancer-after-neoadjuvant-chemoradiotherapy-what-are-we-doing
#12
Fraser McLean Smith, Abdul Ahad, Rodrigo Oliva Perez, John Marks, Krzysztof Bujko, Richard J Heald
BACKGROUND: Recent evidence shows that the majority of rectal cancers demonstrate occult tumor scatter after neoadjuvant chemoradiotherapy that can extend for several centimeters under adjacent normal-appearing mucosa beside the residual mucosal abnormality or scar. OBJECTIVE: This systematic review aimed to determine all of the published selection criteria and technical descriptions for local excision to date with regard to this phenomenon. DATA SOURCES: PubMed, MEDLINE, and Embase were searched using the following key words: rectal cancer, local excision, radiotherapy, and neoadjuvant...
February 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28059911/transanal-endoscopic-microsurgery-for-early-rectal-cancer-a-single-center-experience
#13
Conor H O'Neill, Joseph Platz, Jesse S Moore, Peter W Callas, Peter A Cataldo
BACKGROUND: There is debate regarding the appropriate use of transanal endoscopic microsurgery for rectal cancer. OBJECTIVE: This study analyzed our single-center experience with transanal endoscopic microsurgery for early rectal cancer. DESIGN: Medical charts of patients who underwent transanal endoscopic microsurgery were reviewed to determine lesion characteristics, as well as operative and treatment characteristics. Complications and recurrences were recorded...
February 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28058590/sphincter-saving-resection-by-cluneal-arched-skin-incision-for-a-gastrointestinal-stromal-tumor-gist-of-the-lower-rectum-a-case-report
#14
Hirofumi Tazawa, Yuzo Hirata, Yoshio Kuga, Toshihiro Nishida, Hideto Sakimoto
BACKGROUND: Planning the surgical strategy for a gastrointestinal stromal tumor (GIST) at the posterior wall of the lower rectum is difficult, as the procedures for the lower rectum are hampered by poor visualization and may cause anal dysfunction or discomfort. We report a novel procedure to resect a submucosal tumor of the rectum. CASE PRESENTATION: A 75-year-old woman presented with metrorrhagia. Endovaginal ultrasonography showed a low echoic tumor. Computed tomography showed an enhanced tumor, measuring 5...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28050622/correlation-between-quantitative-and-semiquantitative-parameters-in-dce-mri-with-a-blood-pool-agent-in-rectal-cancer-can-semiquantitative-parameters-be-used-as-a-surrogate-for-quantitative-parameters
#15
Rebecca A P Dijkhoff, Monique Maas, Milou H Martens, Nikolaos Papanikolaou, Doenja M J Lambregts, Geerard L Beets, Regina G H Beets-Tan
PURPOSE: The aim of this study was to assess correlation between quantitative and semiquantitative parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in rectal cancer patients, both in a primary staging and restaging setting. MATERIALS AND METHODS: Nineteen patients were included with DCE-MRI before and/or after neoadjuvant therapy. DCE-MRI was performed with gadofosveset trisodium (Ablavar(®), Lantheus Medical Imaging, North Billerica, Massachusetts, USA)...
January 3, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28044949/sphincter-sparing-surgery-in-patients-with-mid-and-low-rectal-cancer-risk-factors-for-local-recurrence-and-anastomotic-leakage
#16
Denis Aslan, Florin Grama, Daniel Cristian, Adrian Bordea, Traean Burcoş
: Background: Rectal cancer is a major health problem. The current treatment of distal rectal cancer involves a multimodality approach aimed at achieving an optimal oncologic control and an increased quality of life. PURPOSE: The purpose of this article is to identify the risk factors for local recurrence and anastomotic leakage after sphincter-sparing surgery for low and mid rectal cancer. Material and Methods: We prospectively analyzed a group of 38 patients with low and middle rectal cancer who underwent sphincter-sparing surgery...
November 2016: Chirurgia
https://www.readbyqxmd.com/read/28035459/understanding-the-factors-associated-with-reduction-in-the-number-of-lymph-nodes-in-rectal-cancer-patients-treated-by-neoadjuvant-treatment
#17
L Bustamante-Lopez, C S Nahas, S C Nahas, U Ribeiro, C F Marques, G Cotti, A Rocco, I Cecconello
INTRODUCTION: Rectal cancer patients frequently present with locally advanced disease for which the standard of care includes neoadjuvant chemoradiotherapy followed by total mesorectal excision. Positive lymph nodes are one of the most powerful risk factors for recurrence and survival in colorectal cancer. In the absence of specific rectal guidelines, the literature recommends to the pathologist to optimize the number of rectal lymph nodes (LN) retrieved. We made a literature review in order to identify factors that could potentially affect the number of LN retrieved in specimens of patients with rectal cancer treated by chemoradiotherapy (CRT) followed by total mesorectal excision (TME)...
December 29, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28027520/lymph-node-yield-after-rectal-resection-in-patients-treated-with-neoadjuvant-radiation-for-rectal-cancer-a-systematic-review-and-meta-analysis
#18
REVIEW
Robert Mechera, Tibor Schuster, Robert Rosenberg, Benjamin Speich
BACKGROUND: The lymph node status represents a major prognostic factor in colorectal cancer. However, it was demonstrated that neoadjuvant chemoradiotherapy (CRT) decreases the numbers of lymph nodes in the specimen. Several studies describe less than 12 lymph nodes in the resected specimen of rectal cancer patients after neoadjuvant radiation. This meta-analysis quantifies the influence of neoadjuvant CRT or radiotherapy (RT) only on the lymph node yield in rectal cancer patients. METHODS: We performed a systematic review and searched PubMed, EMBASE and the Cochrane Library without any language restriction from 1st of January 1980 until 31st March 2015...
December 24, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/28025227/rectal-cancer-restaging-using-3d-cube-vs-2d-t2-weighted-technique-after-neoadjuvant-therapy-a-diagnostic-study
#19
Wuteng Cao, Yanbang Lian, Dechao Liu, Fangqian Li, Pan Zhu, Zhiyang Zhou
OBJECTIVE: This study aimed to compare the accuracy of rectal cancer restaging after neoadjuvant therapy with 3D CUBE sequence with 2D T2-weighted fast spin-echo (FSE) sequence. METHODS: This retrospective study comprised 72 patients with rectal cancer confirmed by colonoscopy and biopsy. After neoadjuvant therapy, all patients underwent pelvic magnetic resonance imaging (MRI) examination at 1.5T MRI sequences including a single coronal 3D CUBE T2-weighted FSE sequence with 1...
December 26, 2016: Gastroenterology Report
https://www.readbyqxmd.com/read/28011887/sweet-syndrome-a-painful-reality
#20
Uqba Khan, Humaira Rizvi, Farman Ali, Daniel Lebovic
Sweet syndrome is a rare disorder that is manifested by constellation of clinical features, including fever, neutrophilic leucocytosis, raised painful plaques on skin and dermal infiltration by neutrophils. Numerous aetiological associations have been reported in the literature, including various haematological malignancies and drugs. Our case was peculiar because of association of capecitabine and Sweet syndrome in rectal cancer. We describe a case of a woman aged 57 years, with recently diagnosed stage III rectal cancer, developed painful erythematous rash over her face along with fever and headache...
December 23, 2016: BMJ Case Reports
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