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https://www.readbyqxmd.com/read/27926555/avoiding-radical-surgery-in-elderly-patients-with-rectal-cancer-is-cost-effective
#1
Christopher Rao, Arthur Sun Myint, Thanos Athanasiou, Omar Faiz, Antony Paul Martin, Brendan Collins, Fraser McLean Smith
BACKGROUND: Radical surgery is associated with significant perioperative mortality in elderly and comorbid populations. Emerging data suggest for patients with a clinical complete response after neoadjuvant chemoradiotherapy that a watch-and-wait approach may provide equivalent survival and oncological outcomes. OBJECTIVE: The purpose of this study was to compare the cost-effectiveness of watch and wait and radical surgery for patients with rectal cancer after a clinical complete response following chemoradiotherapy...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27917208/histologic-response-after-neoadjuvant-chemoradiotherapy-in-locally-advanced-rectal-adenocarcinoma-experience-from-sudan
#2
Ahmed Abd Elrahman Abdalla, Awad Ali M Alawad, Hussein Abdalla M Ali
BACKGROUND: Locally advanced rectal cancer can be down staged by neoadjuvant therapy and the resultant tumor response can be quantified histologically. This study aimed to assess pathological response of neoadjuvant chemoradiation in patients with locally advanced rectal cancers treated in Wad Medani Teaching Hospital (WMTH) and National Cancer Institute (NCI), Wad Medani, Sudan. PATIENTS AND METHODS: A total of 36 consecutive patients with locally advanced rectal cancer that were managed in WMTH and NCI during the period from 2006-2011 were reviewed...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27904939/-time-interval-between-neoadjuvant-radiochemotherapy-and-surgery-in-rectal-cancer-no-impact-on-the-pathologic-complete-response-rate
#3
Cihan Gani, Daniel Zips
No abstract text is available yet for this article.
November 30, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27903247/preoperative-conventional-chemoradiotherapy-versus-short-course-radiotherapy-with-delayed-surgery-for-rectal-cancer-results-of-a-randomized-controlled-trial
#4
Tadas Latkauskas, Henrikas Pauzas, Laura Kairevice, Aleksandras Petrauskas, Zilvinas Saladzinskas, Rasa Janciauskiene, Jurate Gudaityte, Paulius Lizdenis, Saulius Svagzdys, Algimantas Tamelis, Dainius Pavalkis
BACKGROUND: There still is no evidence which neoadjuvant therapy regimen for stage II-III rectal cancer is superior. The aim of this study was to compare results achieved after long-course chemoradiotherapy (CRT) with short-term radiotherapy (RT) followed by delayed surgery. METHODS: A randomized trial was carried out between 2007-2013. One hundred fifty patients diagnosed with stage II-III rectal cancer were randomized into one of two neoadjuvant treatment arms: conventional chemoradiotherapy (CRT) and short-term radiotherapy (RT) followed by surgery after 6-8 weeks...
December 1, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27894710/bowel-dysfunction-after-anastomotic-leakage-in-laparoscopic-sphincter-saving-operative-intervention-for-rectal-cancer-a-case-matched-study-in-46-patients-using-the-low-anterior-resection-score
#5
Elisabeth Hain, Gilles Manceau, Léon Maggiori, Cécile Mongin, Justine Prost À la Denise, Yves Panis
BACKGROUND: After sphincter-saving operation for rectal cancer, the impact of anastomotic leakage on function has been well studied. The purpose of the present work was to assess the influence of symptomatic and asymptomatic anastomotic leakage on bowel function and health-related quality of life using the Low Anterior Resection Syndrome score and the disease-specific questionnaire European Organization for Research and Treatment of Quality of Life Questionnaire for Colorectal Cancer...
November 25, 2016: Surgery
https://www.readbyqxmd.com/read/27891147/effect-of-neoadjuvant-chemoradiotherapy-with-capecitabine-versus-fluorouracil-for-locally-advanced-rectal-cancer-a-meta-analysis
#6
REVIEW
Guo-Chen Liu, Jun-Ping Yan, Qing He, Xin An, Zhi-Zhong Pan, Pei-Rong Ding
A meta-analysis was carried out to compare the efficacy and safety of capecitabine plus radiation with 5-fluorouracil (5-FU) plus radiotherapy (RT) as neoadjuvant treatment in locally advanced rectal cancer (LARC). We searched the Cochrane database, Ovid, Medline, Embase, ISI databases, and Chinese Biomedical Literature Database between January 1998 and October 2014. Trials of capecitabine compared with 5-FU plus RT as neoadjuvant treatment for LARC were considered for inclusion. RevMan software was used to analyze these data...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27885800/sacral-neuromodulation-for-the-treatment-of-faecal-incontinence-following-proctectomy
#7
Ido Mizrahi, Sami A Chadi, Nadav Haim, Dana R Sands, Brooke Gurland, Massarat Zutshi, Steven D Wexner, Giovanna da Silva
AIM: This study assessed the effectiveness of sacral neuromodulation (SNM) for faecal incontinence (FI) following proctectomy with colorectal or coloanal anastomosis. METHODS: An IRB-approved database identified patients treated for FI following proctectomy (SNM-P) for benign or malignant disease, who were matched 1:1 by pre-operative Cleveland Clinic Florida Faecal Incontinence Scores (CCF-FIS) with patients without proctectomy (SNM-NP). Primary outcome was change in CCF-FIS...
November 25, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27885480/a-single-institution-s-long-term-follow-up-of-patients-with-pathological-complete-response-in-locally-advanced-rectal-adenocarcinoma-following-neoadjuvant-chemoradiotherapy
#8
Franscois Runau, Anna Collins, Glenn Ace Fenech, Eleanor Ford, Nikoletta Dimitriou, Sanjay Chaudhri, Justin M C Yeung
PURPOSE: This paper aimed to study the long term follow-up of patients with primary rectal adenocarcinoma receiving neoadjuvant chemoradiotherapy who obtained a pathological complete response (pCR) and identify factors predicting complete response. METHODS: Retrospective review of notes, histology, pre-operative full blood count and imaging of patients with primary rectal adenocarcinoma diagnosed in our institute from 2000 to 2012 from a prospectively maintained database were used...
November 24, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27885479/wait-and-see-approach-for-rectal-cancer-with-a-clinically-complete-response-after-neoadjuvant-concurrent-chemoradiotherapy
#9
Hyun Jung Kim, Jin Ho Song, Hyeong Sik Ahn, Bong-Hoi Choi, Hojin Jeong, Hoon Sik Choi, Yun Hee Lee, Ki Mun Kang, Bae Kwon Jeong
PURPOSE: Rectal cancer patients with a pathological complete response (pCR) after neoadjuvant concurrent chemoradiotherapy (CCRT) have a better prognosis compared to those without a pCR. Therefore, the "Wait and See" (W&S) approach in those who achieved clinically complete response (cCR) after CCRT was introduced as an alternative modality to the total mesorectal excision (TME). The aim of this study was to compare the oncological outcomes between W&S and TME via meta-analysis. METHODS: We performed a comprehensive literature search on January 14, 2016, using MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, and Scopus...
November 24, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27884204/lateral-pelvic-lymph-node-dissection-after-neoadjuvant-chemo-radiation-for-preoperative-enlarged-lateral-nodes-in-advanced-low-rectal-cancer-study-protocol-for-a-randomized-controlled-trial
#10
Mingtian Wei, Qingbin Wu, Chuanwen Fan, Yan Li, Xiangzheng Chen, Zongguang Zhou, Junhong Han, Ziqiang Wang
BACKGROUND: Lateral lymph node (LLN) metastasis is a major cause of local recurrence of advanced rectal cancer. Although there is much controversy between Western and Eastern countries on whether lateral pelvic lymph node dissection (LLND) or neoadjuvant chemo-radiation (nCRT) is preferable for the treatment of LLN metastases, existing retrospective cohorts mainly focus on all middle/low advanced rectal cancer patients, not the specific individuals with suspicion of LLN metastases. The aim of this trial is to assess the efficacy and safety of LLND for rectal cancer patients with suspicion of LLN metastases...
November 25, 2016: Trials
https://www.readbyqxmd.com/read/27881048/accuracy-of-pre-treatment-locoregional-rectal-cancer-staging-in-a-national-improvement-project
#11
Bart Op de Beeck, Peter Smeets, Freddy Penninckx, Piet Pattyn, Geert Silversmit, Elizabeth Van Eycken
BACKGROUND: The aim of this study was to assess the accuracy, particularly the predictive value, of locoregional clinical rectal cancer staging (cTN) and its variability in a national improvement project. METHODS: cTN stages and the distance between tumour and mesorectal fascia (MRF) were compared with histopathological findings in 1168 patients who underwent radical resection without neoadjuvant treatment. Data were registered prospectively from 2006 to 2014. RESULTS: Agreement between clinical and histopathological TN stages was 50%, independent of tumour location...
November 24, 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27875904/timing-of-rectal-cancer-surgery-following-neoadjuvant-chemoradiation-how-close-are-we-to-striking-an-equipoise
#12
Savio George Barreto, Bhawna Sirohi, Shailesh V Shrikhande
No abstract text is available yet for this article.
November 23, 2016: Future Oncology
https://www.readbyqxmd.com/read/27873100/the-pretreatment-systemic-inflammatory-response-is-an-important-determinant-of-poor-pathologic-response-for-patients-undergoing-neoadjuvant-therapy-for-rectal-cancer
#13
Stephan B Dreyer, Arfon G M T Powell, Stephen T McSorley, Ashita Waterston, James J Going, Joanne Edwards, Donald C McMillan, Paul G Horgan
BACKGROUND: Not all patients respond equally to neoadjuvant chemoradiotherapy (nCRT), with subsequent effects on survival. The systemic inflammatory response has been shown to predict long-term outcomes in colorectal cancer. The current study examined the association between systemic inflammation and nCRT in patients with rectal cancer. METHODS: Between 1999 and 2010, patients who underwent nCRT were identified. Serum measurements of hemoglobin, C-reactive protein, albumin, modified Glasgow prognostic score (mGPS), and differential white cell counts were obtained before and after nCRT...
November 21, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27872117/protocol-for-a-multicentre-randomised-feasibility-trial-evaluating-early-surgery-alone-in-low-rectal-cancer-sailor
#14
Dean A Harris, Kymberley Thorne, Hayley Hutchings, Saiful Islam, Gail Holland, Olivia Hatcher, Sarah Gwynne, Ian Jenkins, Peter Coyne, Michael Duff, Melanie Feldman, Des C Winter, Simon Gollins, Phil Quirke, Nick West, Gina Brown, Deborah Fitzsimmons, Alan Brown, John Beynon
INTRODUCTION: There are 11 500 rectal cancers diagnosed annually in the UK. Although surgery remains the primary treatment, there is evidence that preoperative radiotherapy (RT) improves local recurrence rates. High-quality surgery in rectal cancer is equally important in minimising local recurrence. Advances in MRI-guided prediction of resection margin status and improvements in abdominoperineal excision of the rectum (APER) technique supports a reassessment of the contribution of preoperative RT...
November 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27864695/adjuvant-chemotherapy-improves-overall-survival-of-rectal-cancer-patients-treated-with-neoadjuvant-chemoradiotherapy-regardless-of-pathologic-nodal-status
#15
Audrey S Kulaylat, Christopher S Hollenbeak, David B Stewart
BACKGROUND: After neoadjuvant chemoradiotherapy for rectal cancer, the interpretation of surgical pathology poses difficulties in deciding the need for adjuvant chemotherapy (AC). The aim of this study was to determine whether there is a survival benefit to providing AC in patients with node-negative disease on surgical pathology. METHODS: Patients with clinical stage II and III rectal adenocarcinoma who received neoadjuvant chemoradiation and definitive surgical resection from 2006 to 2012 were identified in the National Cancer Data Base...
November 18, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27861230/structured-reporting-of-rectal-magnetic-resonance-imaging-in-suspected-primary-rectal-cancer-potential-benefits-for-surgical-planning-and-interdisciplinary-communication
#16
Dominik Nörenberg, Wieland H Sommer, Wolfgang Thasler, Jan DʼHaese, Markus Rentsch, Thomas Kolben, Andreas Schreyer, Carsten Rist, Maximilian Reiser, Marco Armbruster
OBJECTIVES: The aim of this study was to evaluate the effect of structured reports (SRs) in comparison to nonstructured, free-text (FT) rectal magnetic resonance imaging (MRI) reports in patients with histologically proven rectal cancer and potential effects of both types of reporting on referring surgeons' satisfaction, interdisciplinary communication, and further clinical decision making. MATERIALS AND METHODS: The institutional review board approved this retrospective study with waiver of informed consent...
November 17, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27845566/the-potential-predictive-value-of-mri-and-pet-ct-in-mucinous-and-nonmucinous-rectal-cancer-to-identify-patients-at-high-risk-of-metastatic-disease
#17
Brunella Barbaro, Lucia Leccisotti, Fabio M Vecchio, Marialuisa Di Matteo, Teresa Serra, Marco Salsano, Andrea Poscia, Claudio Coco, Roberto Persiani, Sergio Alfieri, Maria Antonietta Gambacorta, Vincenzo Valentini, Alessandro Giordano, Lorenzo Bonomo
OBJECTIVES: To correlate imaging parameters from baseline magnetic resonance imaging (MRI)-diffusion-weighted imaging (DWI) and -2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography-computed tomography (PET-CT) with synchronous and metachronous metastases in mucinous (MC) and nonmucinous (NMC) rectal cancer. METHODS: 111 patients with extraperitoneal locally advanced rectal cancer who underwent pelvic MRI, DWI and FDG PET-CT were stratified into MC (n=23) and NMC (n=88)...
November 15, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27837319/functional-outcomes-after-tem-in-patients-with-complete-clinical-response-after-neoadjuvant-chemoradiotherapy
#18
Roberto Ghiselli, Monica Ortenzi, Luca Cardinali, Edlira Skrami, Rosaria Gesuita, Mario Guerrieri
BACKGROUND: In patients who exhibit a complete clinical response after radio-chemotherapy for rectal cancer, the standard surgical approach might constitute overtreatment. The aim of this study is to analyse the outcomes of anorectal function and quality of life after transanal endoscopic microsurgery (TEM) in irradiated patients with complete clinical response. PATIENTS AND METHODS: Between 2007 and 2014, 84 patients who were diagnosed with stage T2-T3-T4 N0 rectal cancer before chemoradiotherapy showed a complete clinical response to neoadjuvant therapy and underwent TEM...
November 11, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27830368/adjuvant-treatment-for-resected-rectal-cancer-impact-of-standard-and-intensified-postoperative-chemotherapy-on-disease-free-survival-in-patients-undergoing-preoperative-chemoradiation-a-propensity-score-matched-analysis-of-an-observational-database
#19
Benjamin Garlipp, Henry Ptok, Frank Benedix, Ronny Otto, Felix Popp, Karsten Ridwelski, Ingo Gastinger, Christoph Benckert, Hans Lippert, Christiane Bruns
AIMS: Adjuvant chemotherapy for resected rectal cancer is widely used. However, studies on adjuvant treatment following neoadjuvant chemoradiotherapy (CRT) and total mesorectal excision (TME) have yielded conflicting results. Recent studies have focused on adding oxaliplatin to both preoperative and postoperative therapy, making it difficult to assess the impact of adjuvant oxaliplatin alone. This study was aimed at determining the impact of (i) any adjuvant treatment and (ii) oxaliplatin-containing adjuvant treatment on disease-free survival in CRT-pretreated, R0-resected rectal cancer patients...
November 9, 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27830030/vnn1-overexpression-is-associated-with-poor-response-to-preoperative-chemoradiotherapy-and-adverse-prognosis-in-patients-with-rectal-cancers
#20
Chi-Yung Chai, Yimin Zhang, Junlong Song, Shih-Chun Lin, Shengrong Sun, I-Wei Chang
BACKGROUND: Colorectal cancer is prevalent worldwide and it is also the fourth most common cause of cancer mortality. For rectal cancer, neoadjuvant concurrent chemoradiotherapy (CCRT) followed by radical proctectomy is gold standard treatment for patients with stage II/III rectal cancer. By data mining a public dataset of rectal cancer transcriptome (GSE35452) from Gene Expression Omnibus, National Center of Biotechnology Information (GEO, NCBI), we identified that VNN1 was the most significantly upregulated gene among those related to nitrogen compound metabolic process (GO:0006807)...
2016: American Journal of Translational Research
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