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https://www.readbyqxmd.com/read/29768703/a-statistical-tool-for-risk-assessment-as-function-of-number-of-retrieved-lymph-nodes-from-rectal-cancer-patients
#1
Zhenyu Wu, Guoyou Qin, Naiqing Zhao, Huixun Jia, Xueying Zheng
PURPOSE: Although a minimum of 12 lymph nodes (LNs) has been recommended for colorectal cancer, there remains considerable debates for rectal cancer patients. Inadequacy of examined LNs would lead to under-staging, and inappropriate treatment as a consequence. We describe statistical tool that allows an estimate the probability of false-negative nodes. METHODS: A total of 26,778 adenocarcinoma rectum cancer patients with tumour stage (T stage) 1-3, diagnosed between 2004 and 2013, who did not receive neoadjuvant therapies and had at least one histologically assessed LN, were extracted from the Surveillance, Epidemiology and End Results (SEER) database...
May 16, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29728843/advanced-imaging-and-hospice-use-in-end-of-life-cancer-care
#2
Michaela A Dinan, Lesley H Curtis, Soko Setoguchi, Winson Y Cheung
INTRODUCTION: Advanced imaging can inform prognosis and may be a mechanism to de-escalate unnecessary end-of-life care in patients with cancer. Associations between greater use of advanced imaging and less-aggressive end-of-life care in real-world practice has not been examined. METHODS: We conducted a retrospective analysis of SEER-Medicare data on patients who died from breast, lung, colorectal, or prostate cancer between 2002 and 2007. Hospital referral region (HRR)-level use of computerized tomography (CT), magnetic resonance imaging, and positron emission tomography was categorized by tertile of imaging use and correlated with hospice enrollment overall and late hospice enrollment using multivariable logistic regression...
May 4, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29726125/long-term-oncological-outcomes-of-local-excision-versus-radical-resection-for-early-colorectal-cancer-in-young-patients-without-preoperative-chemoradiotherapy-a-population-based-propensity-matching-study
#3
Bin Cao, Li Min, Shengtao Zhu, Haiyun Shi, Shutian Zhang
The incidence and mortality of colorectal carcinoma are rising in young adults. This population-based propensity matching study aimed to compare long-term oncological outcomes of local excision with radical resection for early localized colorectal cancer (CRC) in young patients without preoperative chemoradiotherapy. Patients under 45 years old with T1 colon or rectal adenocarcinoma who underwent local excision or radical resection were included from the Surveillance, Epidemiology, and End Results (SEER) database between 1998 and 2014...
May 3, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29721057/survival-contradiction-between-stage-iia-and-stage-iiia-rectal-cancer-a-retrospective-study
#4
Shaobo Mo, Weixing Dai, Wenqiang Xiang, Ben Huang, Yaqi Li, Yang Feng, Qingguo Li, Guoxiang Cai
Background: When compared with patients harboring stage IIB and stage IIC disease, those with stage IIIA colorectal cancer have a better prognosis. We aimed to compare the cause-specific survival (CSS) of the patients with stage IIA rectal cancer with that of the patients with stage IIIA rectal cancer. Methods: Data analyzed about patients with stage IIA and stage IIIA rectal cancer was from the US Surveillance, Epidemiology, and End Results (SEER) database. We then validated the results using data derived from Fudan University Shanghai Cancer Center (FUSCC)...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29705770/post-treatment-surveillance-testing-of-patients-with-colorectal-cancer-and-the-association-with-survival-protocol-for-a-retrospective-cohort-study-of-the-surveillance-epidemiology-and-end-results-seer-medicare-database
#5
Robert B Hines, Md Jibanul Haque Jiban, Kanak Choudhury, Victoria Loerzel, Adrian V Specogna, Steven P Troy, Shunpu Zhang
INTRODUCTION: Although the colorectal cancer (CRC) mortality rate has significantly improved over the past several decades, many patients will have a recurrence following curative treatment. Despite this high risk of recurrence, adherence to CRC surveillance testing guidelines is poor which increases cancer-related morbidity and potentially, mortality. Several randomised controlled trials (RCTs) with varying surveillance strategies have yielded conflicting evidence regarding the survival benefit associated with surveillance testing...
April 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29703172/the-accuracy-of-chemotherapy-ascertainment-among-colorectal-cancer-patients-in-the-surveillance-epidemiology-and-end-results-registry-program
#6
Mark A Healy, Arden M Morris, Paul Abrahamse, Kevin C Ward, Ikuko Kato, Christine M Veenstra
BACKGROUND: Surveillance, Epidemiology, and End Results (SEER) public research database does not include chemotherapy data due to concerns for incomplete ascertainment. To compensate for perceived lack of data quality many researchers use SEER-Medicare linked data, limiting studies to persons over age 65. We sought to determine current SEER ascertainment of chemotherapy receipt in two relatively large SEER registries compared to patient-reported receipt and to assess patterns of under-ascertainment...
April 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29546559/the-effect-of-marital-status-by-age-on-patients-with-colorectal-cancer-over-the-past-decades-a-seer-based-analysis
#7
Yang Feng, Weixing Dai, Yaqi Li, Shaobo Mo, Qingguo Li, Sanjun Cai
OBJECTIVE: Marital status has been found as an independent prognostic factor for survival in colorectal cancer (CRC). However, it is unclear whether patients with different marital status have benefited the same from the treatment improvement. METHODS: We queried the Surveillance, Epidemiology, and End Results (SEER) 9 database for patients diagnosed with CRC from 1975 to 2009. Yearly survival data was presented with overlying loess smoothing lines, stratifying by marital status...
March 15, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29503298/indian-health-service-care-system-and-cancer-stage-in-american-indians-and-alaska-natives
#8
Andrea N Burnett-Hartman, Scott V Adams, Aasthaa Bansal, Jean A McDougall, Stacey A Cohen, Andrew Karnopp, Victoria Warren-Mears, Scott D Ramsey
PURPOSE: We aimed to determine whether the association between late-stage cancer and American Indian/Alaska Native (AI/AN) race differed by enrollment in the Indian Health Service Care System (IHSCS). METHODS: We used Surveillance, Epidemiology, and End Results (SEER) data linked to Medicare files to compare the odds of late-stage breast, colorectal, lung, or prostate cancer between non-Hispanic Whites (NHWs) (n=285,993) and AI/ANs with (n=581) and without (n=543) IHSCS enrollment...
2018: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/29479835/racial-ethnic-disparities-in-de-novo-metastases-sites-and-survival-outcomes-for-patients-with-primary-breast-colorectal-and-prostate-cancer
#9
Tomi Akinyemiju, Swati Sakhuja, John Waterbor, Maria Pisu, Sean F Altekruse
Racial disparities in cancer mortality still exist despite improvements in treatment strategies leading to improved survival for many cancer types. In this study, we described race/ethnic differences in patterns of de novo metastasis and evaluated the association between site of de novo metastasis and breast, prostate, and colorectal cancer mortality. Data were obtained from the Surveillance Epidemiology and Ends Results (SEER) database from 2010 to 2013 and included 520,147 patients ages ≥40 years with primary diagnosis of breast, colorectal, or prostate cancer...
April 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29473344/employment-benefits-and-job-retention-evidence-among-patients-with-colorectal-cancer
#10
Christine M Veenstra, Paul Abrahamse, Todd H Wagner, Sarah T Hawley, Mousumi Banerjee, Arden M Morris
A "health shock," that is, a large, unanticipated adverse health event, can have long-term financial implications for patients and their families. Colorectal cancer is the third most commonly diagnosed cancer among men and women and is an example of a specific health shock. We examined whether specific benefits (employer-based health insurance, paid sick leave, extended sick leave, unpaid time off, disability benefits) are associated with job retention after diagnosis and treatment of colorectal cancer...
March 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29443647/system-level-health-care-integration-and-the-costs-of-cancer-care-across-the-disease-continuum
#11
Deborah R Kaye, Hye Sung Min, Edward C Norton, Zaojun Ye, Jonathan Li, James M Dupree, Chad Ellimoottil, David C Miller, Lindsey A Herrel
PURPOSE: Policy reforms in the Affordable Care Act encourage health care integration to improve quality and lower costs. We examined the association between system-level integration and longitudinal costs of cancer care. METHODS: We used linked SEER-Medicare data to identify patients age 66 to 99 years diagnosed with prostate, bladder, esophageal, pancreatic, lung, liver, kidney, colorectal, breast, or ovarian cancer from 2007 to 2012. We attributed each patient to one or more phases of care (ie, initial, continuing, and end of life) according to time from diagnosis until death or end of study interval...
March 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29391306/incidence-patterns-of-colorectal-cancers-in-four-countries-of-the-middle-east-cancer-consortium-cyprus-jordan-israel-and-%C3%A4-zmir-turkey-compared-with-those-in-the-united-states-surveillance-epidemiology-and-end-results-program
#12
Sultan Eser, Jenny Chang, Haris Charalambous, Barbara Silverman, Anna Demetriou, Cankut Yakut, Omar Nimri, Pavlos Pavlou, Suriye Özgür, Argyrious Ziogas, Lisa Stevens, Kevin Ward, Hoda Anton Culver
BACKGROUND/AIMS: There are wide variations in colorectal cancer (CRC) incidence across the world. Historically, the highest incidence rates have been reported historically in more developed countries; however, increasing trends have been seen in developing countries. Here, we present the CRC incidence pattern in Cyprus, Israel, Jordan, and İzmir, Turkey, which are countries of the Middle East Cancer Consortium (MECC). MATERIALS AND METHODS: We analyzed 2005-2010 CRC data from population-based registries and calculated crude and age standardized rates for CRC, colon and rectum subsites, and annual percent changes (APCs) for trends...
January 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29385768/evaluation-of-colorectal-cancer-incidence-trends-in-the-united-states-2000-2014
#13
Benjamin E Ansa, Steven S Coughlin, Ernest Alema-Mensah, Selina A Smith
Colorectal cancer (CRC) incidence rates have declined in recent years for people of all races/ethnicities; however, the extent to which the decrease varies annually by demographic and disease-related characteristics is largely unknown. This study examines trends and annual percent change (APC) in the incidence among persons diagnosed with CRC in the United States of America from 2000-2014. The data obtained from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program were analyzed, and all persons ( N = 577,708) with malignant CRC recorded in the SEER 18 database from 2000 to 2014 were characterized according to sex, race, age at diagnosis, disease site and stage...
January 30, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29337636/new-onset-cardiovascular-morbidity-in-older-adults-with-stage-i-to-iii-colorectal-cancer
#14
Kelly M Kenzik, Courtney Balentine, Joshua Richman, Meredith Kilgore, Smita Bhatia, Grant R Williams
Purpose We sought to determine the long-term risk of cardiovascular disease (CVD)-stroke and myocardial infarction-and congestive heart failure (CHF) in older patients with colorectal cancer, as well as to understand the roles that preexisting comorbidities and cancer therapy play in increasing this risk. Patients and Methods We evaluated individuals from the SEER-Medicare database with incident stage I to III colorectal cancer at age older than 65 years between January 1, 2000, and December 31, 2011 (n = 72,408) and compared these patients with a matched cohort of Medicare patients without cancer (n = 72,408)...
February 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29312566/trends-in-colorectal-cancer-mortality-in-hispanics-a-seer-analysis
#15
Afsaneh Barzi, Dongyun Yang, Sayedamin Mostofizadeh, Heinz-Josef Lenz
Background: Colorectal cancer (CRC) mortality among Hispanics is lower than Non-Hispanic Whites (NHW). If Hispanics receive equitable care and achieve the same degree of health benefit, their trend of better survival should be maintained. This study assesses mortality trends among Hispanics overtime to compare their survival improvement with NHW. Methods: We used the Incidence-Based Mortality database of the Surveillance, Epidemiology, and End Results Program (SEER) to assess the mortality gap, which is defined as the difference in stage-specific mortality between NHWs and Hispanics, and currently has an advantage for Hispanics...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310604/a-modified-tnm-staging-system-for-non-metastatic-colorectal-cancer-based-on-nomogram-analysis-of-seer-database
#16
Xiangxing Kong, Jun Li, Yibo Cai, Yu Tian, Shengqiang Chi, Danyang Tong, Yeting Hu, Qi Yang, Jingsong Li, Graeme Poston, Ying Yuan, Kefeng Ding
BACKGROUND: To revise the American Joint Committee on Cancer TNM staging system for colorectal cancer (CRC) based on a nomogram analysis of Surveillance, Epidemiology, and End Results (SEER) database, and to prove the rationality of enhancing T stage's weighting in our previously proposed T-plus staging system. METHODS: Total 115,377 non-metastatic CRC patients from SEER were randomly grouped as training and testing set by ratio 1:1. The Nomo-staging system was established via three nomograms based on 1-year, 2-year and 3-year disease specific survival (DSS) Logistic regression analysis of the training set...
January 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29249645/healthcare-experience-among-older-cancer-survivors-analysis-of-the-seer-cahps-dataset
#17
Michael T Halpern, Matthew P Urato, Lisa M Lines, Julia B Cohen, Neeraj K Arora, Erin E Kent
OBJECTIVE: Little is known about factors affecting medical care experiences of cancer survivors. This study examined experience of care among cancer survivors and assessed associations of survivors' characteristics with their experience. MATERIALS AND METHODS: We used a newly-developed, unique data resource, SEER-CAHPS (NCI's Surveillance Epidemiology and End Results [SEER] data linked to Medicare Consumer Assessment of Healthcare Providers and Systems [CAHPS] survey responses), to examine experiences of care among breast, colorectal, lung, and prostate cancer survivors age >66years who completed CAHPS >1year after cancer diagnosis and survived ≥1year after survey completion...
December 14, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29223986/-kras-testing-tumor-location-and-survival-in-patients-with-stage-iv-colorectal-cancer-seer-2010-2013
#18
Mary E Charlton, Amanda R Kahl, Alissa A Greenbaum, Jordan J Karlitz, Chi Lin, Charles F Lynch, Vivien W Chen
Purpose: KRAS mutations and tumor location have been associated with response to targeted therapy among patients with stage IV colorectal cancer (CRC) in various trials. This study performed the first population-based examination of associations between KRAS mutations, tumor location, and survival, and assessed factors associated with documented KRAS testing. Methods: Patients with stage IV adenocarcinoma of the colon/rectum diagnosed from 2010 to 2013 were extracted from SEER data. Analyses of patient characteristics, KRAS testing, and tumor location were conducted using logistic regression...
December 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29179513/the-impacts-of-surgery-of-the-primary-cancer-and-radiotherapy-on-the-survival-of-patients-with-metastatic-rectal-cancer
#19
Duo Tong, Fei Liu, Wenhua Li, Wen Zhang
The role of surgery of the primary cancer and radiation in metastatic colorectal cancer (mCRC) is still controversial currently, and evidence implied that colon cancer (CC) and rectal cancer (RC) should be treated with difference. Hence we focused on metastatic rectal cancer (mRC) solely to compare the cancer cause-specific survival (CSS) of patients receiving varied treatments of the primary cancer: no treatment, surgery only, radiation only, and surgery plus radiation, based on the records of the Surveillance, Epidemiology, and End Results (SEER) database...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29168934/challenging-a-dogma-five-year-survival-does-not-equal-cure-in-all-colorectal-cancer-patients
#20
Omar Abdel-Rahman
BACKGROUND: The current study tried to evaluate the factors affecting 10- to 20- years' survival among long term survivors (>5 years) of colorectal cancer (CRC). METHODS: Surveillance, Epidemiology and End Results (SEER) database (1988-2008) was queried through SEER*Stat program.Univariate probability of overall and cancer-specific survival was determined and the difference between groups was examined. Multivariate analysis for factors affecting overall and cancer-specific survival was also conducted...
February 2018: Expert Review of Anticancer Therapy
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