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https://www.readbyqxmd.com/read/28185118/gastric-cancer-in-fap-a-concerning-rise-in-incidence
#1
Gautam Mankaney, Pamela Leone, Michael Cruise, Lisa LaGuardia, Margaret O'Malley, Amit Bhatt, James Church, Carol A Burke
The highest cancer risks in familial adenomatous polyposis (FAP) include colorectal, duodenal, and thyroid for which surveillance is recommended. Nearly all patients with FAP have gastric fundic gland polyposis (FGP), but gastric cancers are rarely reported with a similar incidence as the general population. We describe a recent, sudden increase in the incidence of gastric cancer in FAP. Seven of the ten cases were diagnosed in the last 20 months. Comparing our population to the SEER database for gastric cancer, the standardized incidence ratio is 140...
February 9, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28156501/using-cancer-registry-records-linked-with-health-insurance-records-to-measure-costs-and-services-at-end-of-life
#2
Catherine R Fedorenko, Kristine Stickney, Cara L McDermott, Ted Conklin, Bruce Smith, Gary H Lyman, Scott David Ramsey
: 186 Background: Studies suggest that end-of-life (EOL) care for persons with cancer in the United States is variable and often misaligned with patient and family preferences. To better understand these issues, we developed reports on high-priority quality indicators and costs at EOL. METHODS: Surveillance, Epidemiology, and End Results (SEER) records for solid tumor patients diagnosed with cancer in Western Washington state between 1/1/2007 and 12/31/2015 were linked with enrollment and claims from two regional commercial insurers...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152886/impact-of-precancer-multimorbidity-clusters-on-survival-and-functional-outcomes-after-cancer-in-older-patients
#3
Joshua Richman, Erin E Kent, Maria Pisu, Smita Bhatia
: 291 Background: While multimorbidity clustering is a significant problem in older adults, the impact of clusters present prior to cancer on post-diagnosis survival and function is unknown. We used SEER-Medicare Health Outcomes Survey data for 4583 cancer patients to address this research gap. METHODS: Patients with prostate (1741), breast (BC: 1345), colorectal (CRC: 904) and lung (593) cancer with pre- and post-diagnosis survey data were included. Surveys assessed comorbidity and activities of daily living (ADLs)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28069852/affordable-care-act-changes-to-medicare-led-to-increased-diagnoses-of-early-stage-colorectal-cancer-among-seniors
#4
Brett Lissenden, Nengliang Aaron Yao
The Affordable Care Act (ACA) helped make preventive care, including recommended cancer screening, more affordable and accessible for millions of Americans. Using population-based data from the Surveillance, Epidemiology, and End Results (SEER) Program, we estimated the impact of ACA policy changes to facilitate the diagnosis of cancer at an earlier and more treatable stage. We estimated that the ACA resulted in an increase of 8,400 (8 percent) diagnoses of early-stage colorectal cancer among US seniors in the period 2011-13...
January 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28045347/depression-treatment-among-elderly-medicare-beneficiaries-with-incident-cases-of-cancer-and-newly-diagnosed-depression
#5
Monira Alwhaibi, Suresh Madhavan, Thomas Bias, Kimberly Kelly, Jamie Walkup, Usha Sambamoorthi
OBJECTIVE: Depression treatment can improve the health outcomes of elderly cancer survivors. There is a paucity of studies on the extent to which depression is treated among elderly cancer survivors. Therefore, this study estimated the rates of depression treatment among elderly cancer survivors and identified the factors affecting depression treatment. METHODS: A retrospective cohort study design was adopted, and data were obtained from the linked Surveillance, Epidemiology and End Results (SEER) and Medicare database...
January 3, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28040719/cancer-type-and-risk-of-newly-diagnosed-depression-among-elderly-medicare-beneficiaries-with-incident-breast-colorectal-and-prostate-cancers
#6
Monira Alwhaibi, Usha Sambamoorthi, Suresh Madhavan, Thomas Bias, Kimberly Kelly, James Walkup
BACKGROUND: Elderly individuals (age >65 years) with cancer are at high risk for newly diagnosed depression after a cancer diagnosis. It is not known whether the risk of newly diagnosed depression varies by cancer type. PURPOSE: To examine the variations in the risk of newly diagnosed depression by cancer type among elderly individuals with cancer. METHODS: This study used a retrospective cohort study design and data from the linked SEER-Medicare files...
January 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28035021/decreasing-black-white-disparities-in-colorectal-cancer-incidence-and-stage-at-presentation-in-the-united-states
#7
Folasade P May, Beth A Glenn, Catherine Crespi, Ninez Ponce, Brennan M R Spiegel, Roshan Bastani
BACKGROUND: There are long-standing black-white disparities in colorectal cancer (CRC) incidence and outcomes in the United States. Incidence and stage at diagnosis reflect the impact of national efforts directed at CRC prevention and control. We aimed to evaluate trends in black-white disparities in both indicators over four decades to inform the future direction of prevention and control efforts. METHODS: We used Surveillance, Epidemiology, & End Results (SEER) data to identify whites and blacks with histologically confirmed CRC from January 1, 1975 through December 31, 2012...
December 29, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27999144/long-term-follow-up-of-patients-having-false-positive-multi-target-stool-dna-tests-after-negative-screening-colonoscopy-the-long-haul-cohort-study
#8
Thomas G Cotter, Kelli N Burger, Mary E Devens, Julie A Simonson, Kari L Lowrie, Russell I Heigh, Douglas W Mahoney, David H Johnson, David A Ahlquist, John B Kisiel
BACKGROUND: Studies of colorectal cancer (CRC) screening by multi-target stool DNA (MT-sDNA) show false positive (FP) rates of 7-13%. It is unclear whether FP patients are at increased long-term risk of adverse outcomes. METHODS: We compared subsequent clinical events among patients with apparent FP MT-sDNA to those in patients reported as true negative (TN). This was a retrospective cohort study of participants in pre-FDA approval MT-sDNA studies having non-advanced or negative baseline colonoscopy findings from a single referral-center...
December 20, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27941905/a-nomogram-improves-ajcc-stages-for-colorectal-cancers-by-introducing-cea-modified-lymph-node-ratio-and-negative-lymph-node-count
#9
Zhen-Yu Zhang, Wei Gao, Qi-Feng Luo, Xiao-Wei Yin, Shiva Basnet, Zhen-Ling Dai, Hai-Yan Ge
Lymph node stages (pN stages) are primary contributors to survival heterogeneity of the 7(th) AJCC staging system for colorectal cancer (CRC), indicating spaces for modifications. To implement the modifications, we selected eligible CRC patients from the Surveillance Epidemiology and End Results (SEER) database as participants in a training (n = 6675) and a test cohort (n = 6760), and verified tumor deposits to be metastatic lymph nodes to derive modified lymph node count (mLNC), lymph node ratio (mLNR), and positive lymph node count (mPLNC)...
December 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27891701/depression-treatment-and-healthcare-expenditures-among-elderly-medicare-beneficiaries-with-newly-diagnosed-depression-and-incident-breast-colorectal-or-prostate-cancer
#10
Monira Alwhaibi, Usha Sambamoorthi, Suresh Madhavan, James T Walkup
OBJECTIVES: Depression is associated with high healthcare expenditures, and depression treatment may reduce healthcare expenditures. However, to date, there have not been any studies on the effect of depression treatment on healthcare expenditures among cancer survivors. Therefore, this study examined the association between depression treatment and healthcare expenditures among elderly with depression and incident cancer. METHODS: The current study utilized a retrospective longitudinal study design using the linked Surveillance, Epidemiology and End Results (SEER)-Medicare database...
November 28, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27882054/risk-of-cancer-among-commercially-insured-hiv-infected-adults-on-antiretroviral-therapy
#11
Jeannette Y Lee, Ishwori Dhakal, Corey Casper, Ariela Noy, Joel M Palefsky, Missak Haigentz, Susan E Krown, Richard F Ambinder, Ronald T Mitsuyasu
The objective of this study was to explore the cancer incidence rates among HIV-infected persons with commercial insurance who were on antiretroviral therapy and compare them with those rates in the general population. Paid health insurance claims for 63,221 individuals 18 years or older, with at least one claim with a diagnostic code for HIV and at least one filled prescription for an antiretroviral medication between January 1, 2006, and September 30, 2012, were obtained from the LifeLink® Health Plan Claims Database...
2016: Journal of Cancer Epidemiology
https://www.readbyqxmd.com/read/27865466/wnt-%C3%AE-catenin-mediated-signaling-commonly-altered-in-colorectal-cancer
#12
J Deitrick, W M Pruitt
Colorectal cancer is the second most common cancer in females and the third most common cancer diagnosed in males (Torre et al.(1)). In 2012, there were about 1.4 million cases and 693,900 deaths due to colorectal cancer worldwide. It is more common in developed countries, and North America, Europe, and Australia have the highest incidence rates. In the United States, adults have a 5% chance of developing colorectal cancer (Cancer of the colon and rectum-SEER stat fact sheets(2)). Due to the high prevalence of colorectal cancer, understanding the mechanism underlying its initiation and progression in order to find better therapeutic agents will have a high impact in the field of oncology and may improve the treatment of other cancers with shared mechanistic properties...
2016: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/27864324/colorectal-cancer-is-a-leading-cause-of-cancer-incidence-and-mortality-among-adults-younger-than-50%C3%A2-years-in-the-usa-a-seer-based-analysis-with-comparison-to-other-young-onset-cancers
#13
Abhishek Bhandari, Melissa Woodhouse, Samir Gupta
Colorectal cancer (CRC) incidence and mortality are rising among young adults. Our aim was to contrast the relative incidence and mortality of CRC to other common cancers among young adults in the USA. We used Surveillance, Epidemiology, and End Results registry data to compare cancer site-specific and age-specific mortality and incident rates for adults younger than age 50. We summarized extracted data, both overall, and stratified by sex. We found CRC was the third leading cause of cancer death among adults younger than age 50, after breast and lung cancer (1...
November 18, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27708217/the-role-of-surgical-intervention-in-primary-colorectal-lymphoma-a-seer-population-based-analysis
#14
Yi-Bo Cai, Hai-Yan Chen, Jin-Jie He, Ye-Ting Hu, Qi Yang, Liu-Bo Chen, Qian Xiao, Ke-Feng Ding
BACKGROUND: Primary colorectal lymphoma (PCL) is a rare colorectal malignancy. The standard treatment and prognostic factors of PCL remain unexplored. Therefore, a large population-based study should be conducted to provide a detailed review of this disease. METHODS: We extracted the data of eligible patients with PCL registered in the SEER database from 1973 to 2011. All statistical analyses were performed using SPSS 19.0. RESULTS: A total of 2050 (61...
September 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27638773/cancer-incidence-in-patients-with-hereditary-hemorrhagic-telangiectasia
#15
Christine W Duarte, Adam W Black, F Lee Lucas, Calvin P H Vary
PURPOSE: Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder characterized by deficiency in endoglin, an angiogenic protein. We previously showed that HHT, in which systemic endoglin expression is reduced, was associated with better survival outcomes in cancer patients (Duarte et al. in Cancer Epidemiol Biomarkers Prev 23:117-125, 2014). Here, we evaluated whether HHT was associated with reduced cancer incidence. METHODS: A matched case-control analysis using SEER Medicare was conducted to evaluate the effect of HHT on diagnosis with breast, colorectal, lung, or prostate cancer between 2000 and 2007 (n = 633,162)...
February 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27609707/decrease-in-incidence-of-colorectal-cancer-among-individuals%C3%A2-50-years-or-older-after-recommendations-for%C3%A2-population-based-screening
#16
Caitlin C Murphy, Robert S Sandler, Hanna K Sanoff, Y Claire Yang, Jennifer L Lund, John A Baron
BACKGROUND & AIMS: The incidence of colorectal cancer (CRC) in the United States is increasing among adults younger than 50 years, but incidence has decreased among older populations after population-based screening was recommended in the late 1980s. Blacks have higher incidence than whites. These patterns have prompted suggestions to lower the screening age for average-risk populations or in blacks. At the same time, there has been controversy over whether reductions in CRC incidence can be attributed to screening...
September 5, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27578387/temporal-trends-in-geographic-and-sociodemographic-disparities-in-colorectal-cancer-among-medicare-patients-1973-2010
#17
Peter S Liang, Jonathan D Mayer, Jon Wakefield, Cynthia W Ko
PURPOSE: Colorectal cancer (CRC) incidence and mortality in the United States have steadily declined since the 1980s, but racial and socioeconomic disparities remain. The influence of geographic factors is poorly understood and may be affected by evolving insurance coverage and screening test uptake. We characterized temporal trends in the association between geographic and sociodemographic factors and CRC outcomes. METHODS: We used the 1973-2010 SEER-Medicare files to identify patients aged ≥65 years with and without CRC...
August 31, 2016: Journal of Rural Health
https://www.readbyqxmd.com/read/27553083/nomograms-to-predict-survival-after-colorectal-cancer-resection-without-preoperative-therapy
#18
Zhen-Yu Zhang, Qi-Feng Luo, Xiao-Wei Yin, Zhen-Ling Dai, Shiva Basnet, Hai-Yan Ge
BACKGROUND: The predictive accuracy of the American Joint Committee on Cancer (AJCC) stages of colorectal cancer (CRC) is mediocre. This study aimed to develop postoperative nomograms to predict cancer-specific survival (CSS) and overall survival (OS) after CRC resection without preoperative therapy. METHODS: Eligible patients with stage I to IV CRC (n = 56072) diagnosed from 2004 to 2010 were selected from the Surveillance, Epidemiology, and End Results (SEER) database...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27535406/comparison-of-comorbid-medical-conditions-in-the-national-cancer-database-and-the-seer-medicare-database
#19
Chun Chieh Lin, Katherine S Virgo, Anthony S Robbins, Ahmedin Jemal, Elizabeth M Ward
BACKGROUND: Physicians routinely factor comorbidities into diagnostic and treatment decisions. Analyses of treatment patterns and outcomes using the National Cancer Data Base (NCDB) usually adjust for comorbidities; however, the completeness of comorbidity ascertainment in the NCDB has never been assessed. We compared the prevalence of comorbidities captured in the NCDB and Surveillance, Epidemiology, and End Results (SEER)-Medicare among female breast, non-small-cell lung, and colorectal cancer patients aged ≥66...
December 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27534517/place-of-death-of-individuals-with-terminal-cancer-new-insights-from-medicare-hospice-place-of-service-codes
#20
Stephanie L Jarosek, Tetyana P Shippee, Beth A Virnig
OBJECTIVES: To use place-of-service (POS) codes in the Medicare hospice claims files to document where elderly hospice users with cancer die. DESIGN: Retrospective cohort study. SETTING: Surveillance, Epidemiology, and End Results (SEER) cancer registry areas. PARTICIPANTS: Elderly Medicare beneficiaries who died of lung, breast, colorectal, or pancreatic cancer in 2007 and 2008 (N = 46,037). MEASUREMENT: Use of hospice, place of service at death (home, nursing home, hospital, inpatient hospice, other), length of stay in hospice...
September 2016: Journal of the American Geriatrics Society
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