Gustavo Yano Callado, Maria Celidonio Gutfreund, Isabele Pardo, Mariana Kim Hsieh, Vivian Lin, Mindy Marie Sampson, Guillermo Rodriguez Nava, Tássia Aporta Marins, Rodrigo Octávio Deliberato, Marinês Dalla Valle Martino, Marisa Holubar, Jorge L Salinas, Alexandre R Marra
BACKGROUND: Penicillin's long-standing role as the reference standard in syphilis treatment has led to global reliance. However, this dependence presents challenges, prompting the need for alternative strategies. We performed a systematic literature review and meta-analysis to evaluate the efficacy of these alternative treatments against nonneurological syphilis. METHODS: We searched MEDLINE, the Cumulative Index to Nursing and Allied Health Literature, Embase, Cochrane, Scopus, and Web of Science from database inception to 28 August 2023, and we included studies that compared penicillin or amoxicillin monotherapy to other treatments for the management of nonneurological syphilis...
April 2024: Open Forum Infectious Diseases