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penetrating keratoplasty

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https://www.readbyqxmd.com/read/29450392/glaucoma-after-penetrating-keratoplasty
#1
REVIEW
Mihail Zemba, Alina-Cristina Stamate
Penetrating keratoplasty is a surgical intervention that despite the progress of surgical techniques and of postoperative treatment continues to have numerous complications. Many of them, such as graft rejection, significant astigmatism, cystoid macular edema, or cataract lead to important limitations of the visual function. Glaucoma is possibly the most dangerous complication following PK, leading to loss of the visual potential of the eye due to irreversible damage to the optic nerve. Identifying the risk factors permits an attentive follow-up and rapid treatment of the postoperative IOP rises...
July 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29450386/penetrating-keratoplasty-from-aid-dependence-to-independence
#2
Mioara-Laura Macovei, Maria-Alexandra Nica
The authors present five cases of bilateral corneal disorders, on which they performed penetrating keratoplasty. All five patients were clinically blind and after the surgery on one eye, they gained their visual independence. Visual acuity, intraocular pressure, fundus examination, and ultrasonography were used to evaluate the patients before and after the surgery.
April 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29445872/bowman-layer-transplantation-5-year-results
#3
Korine van Dijk, Jack S Parker, Lamis Baydoun, Abbas Ilyas, Isabel Dapena, Esther A Groeneveld-van Beek, Gerrit R J Melles
PURPOSE: The purpose of this study was to evaluate the 5-year clinical results of isolated Bowman layer (BL) transplantation in the treatment of advanced keratoconus. METHODS: In this prospective, single-center, interventional case series at a tertiary referral center, 20 eyes of 17 patients with advanced keratoconus underwent BL transplantation, i.e. an isolated Bowman layer graft was positioned into a manually dissected mid-stromal pocket. Scheimpflug-based corneal tomography measurements, best corrected spectacle and contact lens visual acuities (BSCVA and BCLVA), endothelial cell density, and complications were evaluated up to 5 years after surgery...
February 14, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29438654/the-significance-of-repeat-cultures-in-the-treatment-of-severe-fungal-keratitis
#4
Kathryn J Ray, N Venkatesh Prajna, Prajna Lalitha, Revathi Rajaraman, Tiruvengada Krishnan, Sushila Patel, Manoranjan Das, Ranjeet Shah, Kavita Dhakhwa, Stephen D McLeod, Michael E Zegans, Nisha R Acharya, Thomas M Lietman, Jennifer Rose-Nussbaumer
PURPOSE: To identify fungal keratitis patients who are at risk of a poor outcome and may benefit from closer follow-up or more aggressive treatment. DESIGN: Secondary analysis of randomized clinical trial data. SUBJECTS: Patients presenting with a smear-positive filamentous fungal ulcer, visual acuity of 20/400 or worse, and who subsequently had a 6-day fungal culture performed at the Aravind Eye Care system (India), Lumbini Eye Hospital (Nepal), or Bharatpur Eye Hospital (Nepal)...
February 10, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29437570/immunosuppression-by-a-subconjunctival-implant-releasing-dexamethasone-in-a-rabbit-model-of-penetrating-keratoplasty
#5
Emmanuel Crouzet, Thibaud Garcin, Anne-Sophie Gauthier, Zhiguo He, Chantal Perrache, Xavier Delavenne, Thierry Basset, Michel Peoc'h, Philippe Gain, Gilles Thuret
AIMS: To evaluate the efficacy of a subconjunctival dexamethasone-releasing implant in preventing rejection of penetrating keratoplasty (PK) in an animal model. METHODS: Twenty-two rabbits underwent allogenic PK. After randomisation, they received either a 700 µg dexamethasone implant under the conjunctiva at the end of surgery (n=10), one dexamethasone 1 mg/mL eye-drop thrice daily (n=6) or a placebo thrice daily (n=6). The suture was left in place. Animals were observed weekly by slit-lamp and optical coherence tomography with quantification of transparency, neovascularisation and central corneal thickness (CCT)...
February 3, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29436059/outcomes-of-penetrating-keratoplasty-following-autologous-cultivated-limbal-epithelial-stem-cell-transplantation
#6
Gustavo S Figueiredo, Borja Salvador-Culla, Oliver J Baylis, Hardeep S Mudhar, Majlinda Lako, Francisco C Figueiredo
PURPOSE: To investigate the outcomes of penetrating keratoplasty (PKP) following autologous cultivated limbal epithelial stem cell transplantation (CLET). METHODS: A prospective, single centre, interventional cohort study investigating patients with unilateral total limbal stem cell deficiency (LSCD) treated with CLET who underwent PKP. Patients with confirmed corneal re-epithelialization > 6 months post-CLET, and with best-corrected visual acuity (BCVA) <0...
February 13, 2018: Stem Cells
https://www.readbyqxmd.com/read/29422758/localized-trichiasis-causing-focal-full-thickness-corneal-edema-endothelial-cell-loss-and-corneal-scarring-requiring-penetrating-keratoplasty
#7
Tiffany Sara Liu, Seth Meskin
The purpose of the study was to report a case of focal trichiasis causing full-thickness corneal edema, scarring, and endothelial cell loss requiring penetrating keratoplasty (PK). A 66-year-old male was referred for trichiasis of the right upper eyelid corresponding to an area of full-thickness corneal edema. No keratic precipitates or guttata was noted. Specular microscopy showed diffuse endothelial cell loss. He was treated with topical steroids and acyclovir with epilation of lashes. Anterior chamber paracentesis was negative for varicella-zoster virus, cytomegalovirus, and herpes simplex virus...
October 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29419526/descemet-stripping-automated-endothelialkeratoplasty-dsaek-versus-repeat-penetrating-keratoplasty-pkp-to-manage-eyes-with-failed-corneal-graft
#8
Abdulrahman Khairallah
BACKGROUND: Failed corneal graft management is a challenge. Descemet stripping automated endothe.lial keratoplasty (DSAEK) and repeat penetrating keratoplasty (PKP) are two options. Only two studies have compared outcomes of DSAEK and PKP in the management of a failed graft. OBJECTIVE: To compare the visual outcomes, changes in intraocular pressure (IOP) and complications in eyes with failed corneal grafts that were subsequently managed with DSAEK and PKP. DESIGN: Retrospective cohort study...
January 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29410297/trends-in-corneal-transplantation-from-2001-to-2016-in-germany-a-report-of-the-dog-section-cornea-and-its-keratoplasty-registry
#9
E Flockerzi, P Maier, D Böhringer, H Reinshagen, F Kruse, C Cursiefen, T Reinhard, G Geerling, N Torun, B Seitz
PURPOSE: The purpose of this retrospective panel study was to provide an overview of absolute numbers, trends in the types of and indications for corneal transplantation in Germany from 2001 to 2016. METHODS: A questionnaire about absolute numbers, types of transplantation and indications was sent to 111 ophthalmological departments in Germany out of which 94 (85%) provided their data. RESULTS: Since the year 2001, the number of corneal transplantations has increased by 1...
February 1, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29408907/five-year-outcomes-of-boston-type-i-keratoprosthesis-as-primary-versus-secondary-penetrating-corneal-procedure-in-a-matched-case-control-study
#10
Kai B Kang, Faris I Karas, Ruju Rai, Joelle A Hallak, Joann J Kang, Jose de la Cruz, Maria S Cortina
Despite improved retention and reduced complication rates paving the way for the current expansion of applications and surge in prevalence for the Boston type I Keratoprosthesis (KPro), the most frequent indication for its implantation today remains prior graft failure. The purpose of this study is to evaluate the long-term outcomes of primary KPro and compare to secondary implantation in a matched cohort study. This study included patients who underwent KPro implantation in a single center by two surgeons between July 2008 and October 2014...
2018: PloS One
https://www.readbyqxmd.com/read/29408830/selective-endothelial-removal-for-peters-anomaly
#11
Yu Qiang Soh, Jodhbir S Mehta
PURPOSE: Peters anomaly is the most common cause of congenital corneal opacities. Although conservative management is often ineffective except in mild cases, surgical intervention in the form of penetrating keratoplasty is fraught with unpredictability and often has unacceptable postoperative outcomes. As such, there is a need to explore alternative surgical interventions that may possibly improve the postoperative visual prognosis in these patients. In this report, we present a case of type 1 Peters anomaly treated by selective endothelial removal without corneal tissue transplantation...
March 2018: Cornea
https://www.readbyqxmd.com/read/29408828/clinical-features-antibiotic-susceptibility-profile-and-outcomes-of-infectious-keratitis-caused-by-stenotrophomonas-maltophilia
#12
Sotiria Palioura, Allister Gibbons, Darlene Miller, Terrence P OʼBrien, Eduardo C Alfonso, Oriel Spierer
PURPOSE: Stenotrophomonas maltophilia, an uncommon cause of infectious keratitis, is difficult to treat because of its resistance to multiple antibiotics. The purpose of this study is to describe the clinical features, antibiotic susceptibility profile, and outcomes of S. maltophilia keratitis. METHODS: A retrospective review of records from 1987 to 2016 identified 26 eyes of 26 patients who were treated at the Bascom Palmer Eye Institute for an S. maltophilia corneal ulcer...
March 2018: Cornea
https://www.readbyqxmd.com/read/29403594/possible-role-of-descemet-stroma-interface-for-descemet-s-membrane-detachment-after-penetrating-keratoplasty
#13
Vivian Wm Ho, Vito Romano, Bernhard Steger, Stephen B Kaye
Purpose: To report two cases of spontaneous Descemet's membrane detachment (DMD) and dehiscence following penetrating keratoplasty (PK). Case Reports: Spontaneous DMD or Descemet's membrane (DM) dehiscence following PK is a rare occurrence. Here, we describe two cases of such an occurrence following PK arising from the graft-host interface. A possible causative relation between DMD/dehiscence and DM-stromal interface attachment is suggested. Conclusion: DMD and dehiscence after PK can be explained by the peripheral thinning of DM and possible changes to the recently characterized anchoring zone of interwoven collagen fibers and proteoglycans at the Descemet-stroma interface...
January 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29390260/paraproteinemic-keratopathy-in-monoclonal-gammopathy-of-undetermined-significance-treated-with-primary-keratoprosthesis-case-report-histopathologic-findings-and-world-literature-review
#14
Homer H Chiang, Rebekah S Wieland, Thomas S Rogers, Pamela C Gibson, George Atweh, Gregory McCormick
RATIONALE: We report a case of paraproteinemic keratopathy associated with monoclonal gammopathy of undetermined significance, treated with keratoprosthesis as a primary penetrating procedure. Histopathological findings and a world literature review are presented. PATIENT CONCERNS: A 74 year old female recently diagnosed with monoclonal gammopathy undetermined significance presented with progressive blurry vision bilaterally. DIAGNOSES: Examination revealed corneal opacities consistent with paraproteinemic keratopathy...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29384805/descemet-stripping-automated-endothelial-keratoplasty-for-failed-penetrating-keratoplasty-influence-of-the-graft-host-junction-on-the-graft-survival-rate
#15
Takashi Omoto, Toshihiro Sakisaka, Tetsuya Toyono, Junko Yoshida, Rika Shirakawa, Takashi Miyai, Satoru Yamagami, Tomohiko Usui
PURPOSE: To investigate the clinical results of Descemet stripping automated endothelial keratoplasty (DSAEK) for failed penetrating keratoplasty (PK) and the influence of the graft-host junction (GHJ) on the graft survival rate. METHODS: Data were retrospectively collected on patient demographics, visual outcomes, complications, and graft survival rate for 17 eyes of 16 patients who underwent DSAEK for failed PK. The graft survival rate was compared between the eyes when divided into a bump group and a well-aligned group according to the shape of the GHJ detected on anterior segment optical coherence tomography...
January 30, 2018: Cornea
https://www.readbyqxmd.com/read/29380790/unusual-ulcerative-keratitis-caused-by-prototheca-wickerhamii-in-a-diabetic-patient
#16
Niveditha Narayanan, D Vaidehi, L Dhanurekha, K Lily Therese, Rama Rajagopal, Radhika Natarajan, Meena Lakshmipathy
The purpose of the study was to report a case of ulcerative keratitis caused by an unusual algae Prototheca wickerhamii in a diabetic patient. This study design was a case report. A 46-year-old male, who was a known diabetic for 3 years, had an injury to the left cornea with the sparks of fire from wielding at work that developed into an ulcerative keratitis over a period of next 3 months as the patient was not on any medication. Corneal scraping culture report and Vitek 2 system investigation result confirmed it to be a P...
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29380771/ocular-manifestations-of-isolated-corneal-bee-sting-injury-management-strategies-and-clinical-outcomes
#17
Hemalatha Gudiseva, Madhu Uddaraju, Sayali Pradhan, Manoranjan Das, Jeena Mascarenhas, M Srinivasan, N Venkatesh Prajna
PURPOSE: The purpose of this study is to describe the presenting features, management strategies, and clinical outcome following bee sting injury to the cornea. METHODS: Retrospective case series involving 11 eyes of 11 patients with corneal bee sting injuries who presented over a period of 2 years. Nine of these 11 eyes had the presence of intact bee stinger in the cornea, which was removed immediately under an operating microscope and sent for microbiological and histopathological evaluation...
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29380761/effect-of-transfer-of-donor-corneal-tissue-from-mccarey-kaufmann-medium-to-optisol-gs-on-corneal-endothelium
#18
Neha Kapur, Sridevi Gunda, Surender Dixit, Lokesh Chauhan, Manisha Acharya, Umang Mathur
PURPOSE: The purpose of this study is to evaluate the effect of transfer of donor corneal tissue from McCarey-Kaufmann (MK) medium to Optisol-GS on corneal endothelium. METHODS: This was a prospective, randomized comparative study. Twenty paired human donor corneal tissues of optical quality were retrieved. One tissue of the pair was preserved in Optisol-GS preservative medium (Group A) and other tissue of the pair in MK medium (Group B) at the time of corneoscleral disc excision...
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29357819/spontaneous-reattachment-of-dislocated-endothelial-graft-after-non-descemet-stripping-automated-endothelial-keratoplasty-a-case-report
#19
Aya Kodama-Takahashi, Masahiko Fukuda, Koji Sugioka, Akira Kobayashi, Yoshikazu Shimomura
BACKGROUND: Graft detachment is a complication of non-Descemet stripping automated endothelial keratoplasty (nDSAEK). We report a case of spontaneous reattachment of an extensively dislocated graft after nDSAEK. CASE PRESENTATION: A 54-year-old male underwent penetrating keratoplasty (PKP) for keratoconus in his left eye in 2001. Following graft opacity due to rejection, a second PKP was implemented in May 2014. The graft was kept in good condition after the reoperation and yet, visual acuity (VA) declined due to cataract...
January 22, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29336641/impact-of-forward-and-backward-scattering-and-corneal-higher-order-aberrations-on-visual-acuity-after-penetrating-keratoplasty
#20
Hidenaga Kobashi, Kazutaka Kamiya, Kimiya Shimizu
PURPOSE: To assess the relationship of forward and backward scattering and corneal higher-order aberrations (HOAs) with corrected distance visual acuity (CDVA) after penetrating keratoplasty (PK). METHODS: This retrospective study comprised 25 eyes of 25 consecutive patients who underwent PK using the VisuMax femtosecond laser system and age-matched 25 eyes of 25 healthy subjects. We quantitatively assessed objective scattering index (OSI) using the double-pass instrument (OQAS II, Visiometrics), corneal densitometry (CD) and corneal HOAs with the Scheimpflug rotating camera (Pentacam HR, Oculus) 1 year postoperatively...
January 16, 2018: Seminars in Ophthalmology
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