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corneal cross linking

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https://www.readbyqxmd.com/read/29677348/the-relationship-of-lid-wiper-epitheliopathy-to-ocular-surface-signs-and-symptoms
#1
Wing Li, Thao N Yeh, Tiana Leung, Tiffany Yuen, Mariel Lerma, Meng C Lin
Purpose: There has been interest in determining whether lid wiper epitheliopathy (LWE) plays a key role in causing ocular discomfort. Conflicting reports have made it difficult to discern whether LWE is more prevalent in certain populations, what characteristics are associated with its severity, and what its role is in symptomology. This cross-sectional study on a large and diverse population attempts to answer these questions. Methods: Subjects were asked to complete questionnaires related to dry eye and to ocular discomfort...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29675563/trans-epithelial-corneal-collagen-cross-linking-with-iontophoresis-for-progressive-keratoconus
#2
Mohammed Ali Abu Ameerh, Muawyah Dawoud Al Bdour, Maha Al-Till, Muhannad Al Faouri
PURPOSE: To evaluate the efficacy of trans-epithelial corneal collagen cross-linking (CXL) with Iontophoresis among patients with progressive keratoconus. METHODS: It is a prospective interventional study, which is based on 41 eyes of 23 patients, suffering from progressive keratoconus and treated with trans-epithelial corneal cross-linking, using iontophoresis with ETDA and trometamol-enriched riboflavin 5 phosphates 0.1% hypotonic solution (Ricrolin+, Soot Italia SpA, Italy)...
April 19, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29675392/efficacy-of-iontophoresis-assisted-epithelium-on-corneal-cross-linking-for-keratoconus
#3
REVIEW
Hong-Zhen Jia, Xiu-Jun Peng
Corneal cross-linking (CXL) is a noninvasive therapeutic procedure for keratoconus that is aimed at improving corneal biomechanical properties by induction of covalent cross-links between stromal proteins. It is accomplished by ultraviolet A (UVA) radiation of the cornea, which is first saturated with photosensitizing riboflavin. It has been shown that standard epithelium-off CXL (S-CXL) is efficacious, and it has been recommended as the standard of care procedure for keratoconus. However, epithelial removal leads to pain, transient vision loss, and a higher risk of corneal infection...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29657977/expert-practice-patterns-and-opinions-on-corneal-cross-linking-for-infectious-keratitis
#4
Yen C Hsia, Caitlin A Moe, Thomas M Lietman, Jeremy D Keenan, Jennifer Rose-Nussbaumer
Objective: To assess the current opinion and practice patterns from cornea experts regarding the benefit of corneal cross-linking (CXL) for infectious keratitis (IK). Methods and analysis: An international survey was distributed to corneal specialists via an internet survey. The survey data collected were analysed with descriptive statistics. Results: A survey was sent to 190 recipients, and 29 (15%) respondents completed the survey with an average of 7 years' experience using CXL...
2018: BMJ open ophthalmology
https://www.readbyqxmd.com/read/29621306/conventional-and-transepithelial-corneal-cross-linking-for-patients-with-keratoconus
#5
Xiaoyu Zhang, Jing Zhao, Meiyan Li, Mi Tian, Yang Shen, Xingtao Zhou
Previous studies investigating the effectiveness of conventional corneal collagen cross-linking (CXL) and transepithelial CXL in keratoconus treatment have reported conflicting outcomes. Therefore, we conducted a meta-analysis to compare the effectiveness of these treatments. We searched MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials for prospective randomized controlled trials (RCTs) with no restrictions. We included visual acuity (corrected distance visual acuity, uncorrected distance visual acuity) and corneal keratometry (K) as primary outcome parameters, and spherical equivalent, central corneal thickness (CCT), and endothelial cell density, as secondary parameters...
2018: PloS One
https://www.readbyqxmd.com/read/29610222/two-year-follow-up-of-corneal-cross-linking-and-refractive-surface-ablation-in-patients-with-asymmetric-corneal-topography
#6
João Baptista N S Malta, H Kaz Soong, Bernardo Kaplan Moscovici, Mauro Campos
AIMS: To evaluate the safety and efficacy of corneal cross-linking (CXL) followed by photorefractive keratectomy (PRK) for refractive correction in patients with bilateral asymmetric topography. METHODS: Forty-four patients (88 eyes) were enrolled in this prospective randomised clinical trial. CXL with subsequent PRK after 6 months was performed in one eye (study group), and PRK alone was performed in contralateral eyes (control group). Patients were followed for 24 months after PRK...
April 2, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29601364/corneal-cross-linking-for-pediatric-keratcoconus-review
#7
Claudia Perez-Straziota, Ronald N Gaster, Yaron S Rabinowitz
PURPOSE: To comprehensively review the available published literature for cross-linking in the pediatric population. METHODS: Review of the literature published in English in PubMed. RESULTS: Two hundred ten publications were considered. One hundred fifteen were considered relevant to this review. CONCLUSIONS: Studies of cross-linking in pediatric patients are sparse, with relatively short follow-up times, and mostly on small groups of patients...
March 28, 2018: Cornea
https://www.readbyqxmd.com/read/29594793/sterile-keratitis-after-uneventful-corneal-collagen-cross-linking-in-a-patient-with-axenfeld-rieger-syndrome
#8
Betul Seher Uysal, Derya Yaman, Ozge Sarac, Emine Akcay, Nurullah Cagil
PURPOSE: To report on a keratoconus (KC) patient with Axenfeld-Rieger syndrome (ARS) who developed sterile keratitis after accelerated corneal collagen cross-linking (CXL). METHODS: An 18-year-old patient with ARS and KC who had previously undergone intrastromal ring segment implantation underwent accelerated CXL (9 mW/cm2  UVA intensity for 10 min). RESULTS: After uneventful surgery, the patient presented with severe photophobia, redness of the eye, and decreased vision 72 h following the procedure...
March 28, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29582259/corneal-densitometry-after-accelerated-corneal-collagen-cross-linking-in-progressive-keratoconus
#9
Myriam Böhm, Mehdi Shajari, Matthias Remy, Thomas Kohnen
PURPOSE: To analyze changes in corneal densitometry 3 months after accelerated corneal collagen cross-linking (CXL) measured with Scheimpflug tomography. METHODS: In this study we reviewed charts and anterior segment data of patients who had undergone accelerated pulsed epithelium-off CXL (30 mW/cm2 for 4 min, 8 min total radiation time) for treatment of progressive keratoconus in the Department of Ophthalmology, Goethe University, Frankfurt, Germany. Visual, topographic, pachymetric and densitometric data were extracted before surgery and at the 3-month follow-up...
March 26, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29576618/effects-of-collagen-cross-linking-on-the-keratoconus-metabolic-network
#10
Rabab Sharif, Henrik Sejersen, Garrett Frank, Jesper Hjortdal, Dimitrios Karamichos
PURPOSE: Keratoconus (KC) is a multifactorial, ectatic corneal disease. Metabolic changes in the corneal stroma with alterations in collagen fibril stability, oxidative stress, and urea cycle, have previously been reported as key players in KC pathobiology. Recently, corneal collagen cross-linking (CXL) has been introduced as a treatment that can address the progressive nature of KC. While the treatment has been successful in the early days, it is not without clinical ramifications. In this study, we investigated the alterations in KC metabolic profiles due to CXL...
March 26, 2018: Eye
https://www.readbyqxmd.com/read/29566537/treatment-with-platelet-rich-plasma-of-surgically-related-dormant-corneal-ulcers
#11
Jorge L Alio, Alejandra E Rodriguez, Pablo De Arriba, Sandra Gisbert, Ahmed A Abdelghany
PURPOSE: To assess the effectiveness of autologous platelet-rich plasma for the treatment of dormant corneal ulcers secondary to corneal surgery and unresponsive to conventional treatment. SETTING: VISSUM, Ophthalmology Institute of Alicante, Alicante, Spain. DESIGN: Prospective nonrandomized, observational consecutive study. METHODS: A total of 44 eyes of 28 patients with dormant corneal ulcers secondary to corneal surgery were included in a prospective study and treated with autologous platelet-rich plasma during 6 weeks...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29564806/prospective-randomized-contralateral-eye-study-of-accelerated-and-conventional-corneal-cross-linking-in-pediatric-keratoconus
#12
Sherif A Eissa, Amr Yassin
PURPOSE: To compare the outcomes of two different cross-linking (CXL) protocols, in pediatric keratoconus eyes. MATERIALS AND METHODS: In this prospective randomized contralateral eye interventional study, 68 eyes of 34 patients, 9-16 years old, underwent CXL and enrolled between October 2011 and October 2013. Group A represents conventional riboflavin-ultraviolet A (UVA)-induced CXL with 30 min of exposure to UVA irradiation of 3 mW/cm2 . Group B represents accelerated cross-linking with 5 min of continuous UVA irradiation of 18 mW/cm2 ...
March 21, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29564410/opd-scan-iii-accuracy-topographic-and-aberrometric-indices-after-accelerated-corneal-cross-linking
#13
Soheila Asgari, Hassan Hashemi
Purpose: To determine topographic and aberrometric changes after accelerated cross-linking (ACXL; 18 mW/cm2 for 5 min) as measured with OPD Scan III (Nidek Inc., Tokyo, Japan) and their repeatability in patients with mild and moderate keratoconus (KCN). Methods: In this prospective study, 25 eyes with mild KCN [Ksteep = 47.24 ± 3.11 diopter (D)] and 20 moderate cases (Ksteep = 52.86 ± 4.39 D) were examined under mesopic conditions (20 lux) twice, 30-45 min apart, at baseline and 6 and 12 months afterwards...
March 2018: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/29561496/effects-of-thickness-on-corneal-biomechanical-properties-using-optical-coherence-elastography
#14
Srilatha Vantipalli, Jiasong Li, Manmohan Singh, Salavat R Aglyamov, Kirill V Larin, Michael D Twa
SIGNIFICANCE: Measured corneal biomechanical properties are driven by intraocular pressure, tissue thickness, and inherent material properties. We demonstrate tissue thickness as an important factor in the measurement of corneal biomechanics that can confound short-term effects due to UV riboflavin cross-linking (CXL) treatment. PURPOSE: We isolate the effects of tissue thickness on the measured corneal biomechanical properties using optical coherence elastography by experimentally altering the tissue hydration state and stiffness...
March 21, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29538101/automated-detection-and-classification-of-corneal-haze-using-optical-coherence-tomography-in-patients-with-keratoconus-after-cross-linking
#15
Ahmad R Dhaini, Maamoun Abdul Fattah, Sara Maria El-Oud, Shady T Awwad
PURPOSE: To evaluate a proposed technology for offering objective grading and mapping of corneal haze as detected by corneal spectral domain optical coherence tomography after corneal cross-linking. METHODS: This was a retrospective study to evaluate corneal optical coherence tomography images performed on 44 eyes of 44 patients who underwent corneal cross-linking between January 2014 and May 2015, at the American University of Beirut Medical Center. RESULTS: Overall average brightness of the cornea was markedly increased from 43...
March 13, 2018: Cornea
https://www.readbyqxmd.com/read/29525838/long-term-database-analysis-of-conventional-and-accelerated-crosslinked-keratoconic-mid-european-eyes
#16
Efstathios Vounotrypidis, Alexis Athanasiou, Karsten Kortüm, Daniel Kook, Mehdi Shajari, Siegfried Priglinger, Wolfgang J Mayer
PURPOSE: To investigate the long-term efficacy of accelerated corneal collagen cross-linking (CXL) in a large mid-European cohort with progressive keratoconus. METHODS: Four hundred thirteen eyes of 316 patients with progressive keratoconus were enrolled and treated with conventional (group A) or accelerated (group B) CXL. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), slit lamp, and Pentacam® examinations were performed before and 12, 24, and 36 months after surgery...
March 10, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29523106/one-year-follow-up-of-accelerated-transepithelial-corneal-collagen-cross-linking-for-progressive-pediatric-keratoconus
#17
Mi Tian, Weijun Jian, Ling Sun, Yang Shen, Xiaoyu Zhang, Xingtao Zhou
BACKGROUND: Keratoconus typically presents in the teenage years and is more advanced in younger patients when compared with adults. In the present study, we aimed to assess the safety and efficacy of accelerated transepithelial corneal collagen cross-linking (ATE-CXL) in children with progressive keratoconus. METHODS: In this retrospective consecutive study, 18 eyes were enrolled from 17 pediatric patients (15 boys and 2 girls) with a mean age of 14.44 ± 1...
March 9, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29522228/the-7-year-outcomes-of-epithelium-off-corneal-cross-linking-in-progressive-keratoconus
#18
Mohamed Shafik Shaheen, Mohamed M Lolah, David P Piñero
PURPOSE: To evaluate the clinical results of epitheliumoff corneal cross-linking (CXL) during a 7-year follow-up. METHODS: This retrospective, non-randomized, single-center interventional study enrolled 34 consecutive eyes of 24 patients with progressive keratoconus undergoing CXL surgery with epithelium removal. Visual, refractive, corneal topographic, pachymetric, and anterior segment changes were evaluated at 1, 3, and 7 years after surgery. RESULTS: Significant reduction of refraction was observed at 1 year postoperatively (P ≤ ...
March 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29522227/progression-of-keratoconus-in-patients-while-awaiting-corneal-cross-linking-a-prospective-clinical-study
#19
Vito Romano, Riccardo Vinciguerra, Esmaeil M Arbabi, Nick Hicks, Pietro Rosetta, Paolo Vinciguerra, Stephen B Kaye
PURPOSE: To assess topographical changes in patients with keratoconus while awaiting corneal cross-linking (CXL) treatment. METHODS: In this prospective, double-center, observational clinical study, patients with keratoconus were enrolled. Progression was defined as a change in the curvature within the cone area of at least 1.00 diopter (D) on tangential map and a thinning of 20 μm at the thinnest point after measurements taken at least 3 months apart. Morphological parameters were assessed at baseline (day of listing for CXL) and on the day of CXL treatment, including slit-lamp biomicroscopy, keratometry (maximum, minimum, and mean), and thinnest corneal thickness using corneal tomography (Pentacam; Oculus Optikgeräte GmbH, Wetzlar, Germany)...
March 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29499665/antimicrobial-efficacy-of-corneal-cross-linking-in-vitro-and-in-vivo-for-fusarium-solani-a-potential-new-treatment-for-fungal-keratitis
#20
Ziqian Zhu, Hongmin Zhang, Juan Yue, Susu Liu, Zhijie Li, Liya Wang
BACKGROUND: Fungal keratitis is one of the major causes of visual impairment worldwide. However, the effectiveness of corneal collagen cross-linking (CXL) for fungal keratitis remains controversial. In this study, we developed an in vitro and an in vivo models to assess the efficacy of CXL for Fusarium keratitis. METHODS: The effect of in vitro CXL fungicidal was evaluated on the cultures of Fusarium solani which were exposed to irradiation for different durations...
March 2, 2018: BMC Ophthalmology
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