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https://www.readbyqxmd.com/read/28730109/human-eye-ocular-component-analysis-for-refractive-state-and-refractive-surgery
#1
Chao-Kai Chang, Jui-Teng Lin, Yong Zhang
AIM: To analyze the clinical factors influencing the human vision corrections via the changing of ocular components of human eye in various applications; and to analyze refractive state via a new effective axial length. METHODS: An effective eye model was introduced by the ocular components of human eye including refractive indexes, surface radius (r1, r2, R1, R2) and thickness (t, T) of the cornea and lens, the anterior chamber depth (S1) and the vitreous length (S2)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28721004/epithelium-on-photorefractive-intrastromal-cross-linking-pixl-for-reduction-of-low-myopia
#2
Wee Kiak Lim, Zhi Da Soh, Harold Kah Yen Choi, Julian Thiam Siew Theng
PURPOSE: To report the 9-12-month outcomes of a novel procedure for reduction of low myopia through epithelium-on photorefractive intrastromal cross-linking (PiXL) with customized control of topographic distribution of ultraviolet (UV)-fluence. METHOD: Myopic patients with normal (non-ectatic) corneas underwent the PiXL procedure for reduction of low myopia. PiXL treatments were delivered through selective application of UVA light based on the refractive error of each patient...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28704317/comparison-of-collagen-cross-linking-and-amniotic-membrane-transplantation-in-an-experimental-alkali-burn-rabbit-model
#3
Sevgi Subasi, Ozgul Altintas, Melda Yardimoglu, Yusufhan Yazir, Suleyman Karaman, Selenay Furat Rencber, Kubra Kavram
PURPOSE: To compare the effects of collagen cross-linking (CXL) and amniotic membrane transplantation (AMT) on acute corneal alkali burns. METHODS: After establishment of an alkali burn model, 32 rabbits were divided into 4 groups: control group, AMT group, CXL group, and AMT + CXL (combined) group. Clinical parameters, including epithelial wound, opacity, ulceration, and neovascularization, were evaluated on postinjury days 1, 7, 14, and 18. Histological parameters were examined in hematoxylin/eosin (H&E) and Masson trichrome-stained corneal sections...
July 11, 2017: Cornea
https://www.readbyqxmd.com/read/28691944/efficacy-and-z-formula-for-minimum-corneal-thickness-in-ultraviolet-light-cross-linking
#4
Jui-Teng Lin
No abstract text is available yet for this article.
July 6, 2017: Cornea
https://www.readbyqxmd.com/read/28691035/corneal-collagen-cross-linking-for-keratoconus-systematic-review
#5
REVIEW
Hidenaga Kobashi, Shi Song Rong
PURPOSE: To evaluate the efficacy of collagen cross-linking (CXL) one year after treatment for keratoconus compared to no treatment by summarizing randomized controlled trials (RCTs) using a systematic review. METHODS: Trials meeting the selection criteria were quality appraised, and the data were extracted by two independent authors. The outcome parameters included maximum keratometry (Kmax), corneal thickness at the thinnest point, best spectacle-corrected visual acuity (BSCVA), uncorrected visual acuity (UCVA), spherical equivalent (SE) refraction, and cylindrical refraction one year after CXL...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28681909/medium-to-long-term-results-of-corneal-cross-linking-for-keratoconus-using-phototherapeutic-keratectomy-for-epithelial-removal-and-partial-stromal-ablation
#6
Xiangjun Chen, Aleksandar Stojanovic, Yangyang Xu, Wen Zhou, Sten Raeder, Sam Enayati, Tor Paaske Utheim
PURPOSE: To evaluate the medium- to long-term outcomes of corneal cross-linking in treatment of keratoconus using transepithelial phototherapeutic keratectomy (PTK-CXL) for epithelial removal and partial stromal ablation to stabilize the cornea, reduce corneal irregularity, and improve corrected vision. METHODS: Retrospective analysis of 46 keratoconic eyes that underwent PTK-CXL. Corrected distance visual acuity (CDVA), manifest refraction, steep and flat simulated keratometry (Kmax and Kmin), corneal irregularity index (IRI), corneal higher order aberrations (HOAs), epithelial thickness profile, and corneal biomechanical characteristics were evaluated preoperatively and postoperatively...
July 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28655729/corneal-collagen-cross-linking-in-paediatric-patients-affected-by-keratoconus
#7
Karl Anders Knutsson, Giorgio Paganoni, Stanislav Matuska, Oriella Ambrosio, Giulio Ferrari, Arianna Zennato, Michela Caccia, Paolo Rama
BACKGROUND/AIMS: To evaluate the effectiveness of corneal collagen cross-linking (CXL) in paediatric patients. METHODS: Fifty-two eyes of 43 paediatric patients with progressive keratoconus were enrolled in a prospective cohort study. Corneal CXL was performed using a conventional technique with instillation of 0.1% riboflavin solution containing dextran 20% for 30 min during the soaking phase and during the 30 min ultraviolet A irradiation (3 mW/cm(2)). Visual outcomes, topographic keratometry, maximum keratometry (K-max), refractive astigmatism, demarcation line and endothelial cell density were measured postoperatively...
June 27, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28646439/alterations-in-contact-lens-fitting-parameters-following-cross-linking-in-keratoconus-patients-of-indian-ethnicity
#8
Kirti Singh, Mainak Bhattacharyya, Ritu Arora, Sonal Dangda, Ankush Mutreja
BACKGROUND: Most studies have either excluded patients using contact lens or not taken their effect while analyzing post-collagen cross-linkage (CXL) changes. This study aims to study impact of CXL on lens fit in both quantitative and qualitative manner. OBJECTIVE: To evaluate changes in CL fit post-CXL and to correlate these changes with alterations in corneal topographic parameters. STUDY DESIGN: Prospective intervention study on 20 keratoconic eyes of 14 patients (age > 18 years), with mean follow-up of 6 months...
June 23, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28644862/high-intensity-corneal-collagen-crosslinking-with-riboflavin-and-uva-in-rat-cornea
#9
Yirui Zhu, Peter S Reinach, Hanlei Zhu, Qiufan Tan, Qinxiang Zheng, Jia Qu, Wei Chen
Corneal collagen cross-linking (CXL) halts human corneal ectasias progression by increasing stromal mechanical stiffness. Although some reports describe that this procedure is effective in dealing with some infectious and immunologic corneal thinning diseases, there is a need for more animal models whose corneal thickness more closely resemble those occurring in these patients. To meet this need, we describe here high-intensity protocols that are safe and effective for obtaining CXL in rat corneas. Initially, a range of potentially effective UVA doses were evaluated based on their effectiveness in increasing tissue enzymatic resistance to dissolution...
2017: PloS One
https://www.readbyqxmd.com/read/28644681/treatment-results-of-corneal-collagen-cross-linking-combined-with-riboflavin-and-440-nm-blue-light-for-bacterial-corneal-ulcer-in-rabbits
#10
Shufang Wei, Cuiying Zhang, Shaoru Zhang, Yanyun Xu, Guoying Mu
PURPOSE: To study the treatment effect of corneal collagen cross-linking (CXL) combined with 440 nm blue light and riboflavin on bacterial corneal ulcer using animal experiments. METHODS: A total of 21 New Zealand white rabbits that developed Staphylococcus aureus corneal ulcer were randomly divided into three groups. Seven rabbits were used as blank control groups; seven rabbits were treated with CXL combined with riboflavin and 440 nm blue light; and seven rabbits were treated with CXL combined with riboflavin and 370 nm ultraviolet A light...
June 23, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28644240/corneal-stiffening-by-a-bacteriochlorophyll-derivative-with-dextran-and-near-infrared-light-effect-of-shortening-irradiation-time-up-to-1-minute
#11
Jurriaan Brekelmans, Alexandra Goz, Mor M Dickman, Alexander Brandis, Xiaomeng Sui, H Daniel Wagner, Rudy M M A Nuijts, Avigdor Scherz, Arie L Marcovich
PURPOSE: The aim of this study is to determine the effect of variation of the exposure time of near-infrared irradiation on corneal stiffening after a bacteriochlorophyll derivative (WST11) with dextran (WST-D) application. METHODS: One hundred four paired eyes of 3-month-old New Zealand White rabbits were included in this study. Fifty-two eyes (ex vivo n = 34, in vivo n = 18) were mechanically deepithelialized, treated topically with WST-D, and irradiated at 10 mW/cm using a diode laser at 755 nm for 1, 5, or 30 minutes...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28626821/mesopic-visual-quality-after-accelerated-corneal-cross-linking-a-12-month-follow-up-study
#12
Hassan Hashemi, Soheila Asgari
PURPOSE: To determine the 1-year changes of mesopic higher order aberrations (HOAs) and contrast sensitivity (CS) after accelerated corneal cross linking (CXL) in progressive keratoconus. METHODS: In this prospective case series, 70 eyes of 62 keratoconic patients underwent accelerated CXL (18 mW/cm(2), 5 min). HOAs and CS were measured using the OPD Scan III and CSV-1000 CS test charts under mesopic conditions before and 6 and 12 months after CXL. RESULTS: At 1 year, logarithmic mesopic CS in spatial frequencies of 3, 6, 12, and 18 cycles per degree (CPD) had increased by 0...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28611646/corneal-cross-linking-as-a-treatment-for-fungal-keratitis-associated-with-corneal-melting
#13
Vadim Igal, Yael Sara Pikkel Igal, Yoav Yechezkel Pikkel
We present the case of a young male that suffered from fungal corneal abscess and corneal melting. The patient was treated successfully by corneal cross-linking. Taking into account our experience from this case, we offer to consider corneal cross-linking as a therapeutic option in cases of fungal keratitis.
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28603017/effects-of-diabetes-mellitus-on-biomechanical-properties-of-the-rabbit-cornea
#14
FangJun Bao, ManLi Deng, XiaoBo Zheng, LinNa Li, YiPing Zhao, Si Cao, AYong Yu, QinMei Wang, JinHai Huang, Ahmed Elsheikh
To investigate the effects of diabetes on the biomechanical behavior of cornea in alloxan-induced diabetic rabbits. Diabetes mellitus (DM) was induced in 20 rabbits using alloxan, while another 20 age- and weight-matched non-diabetic rabbits served as controls. Eyes were enucleated after 8 weeks of inducing diabetes and the whole cornea was removed with a 3 mm wide scleral ring and tested under inflation conditions with an internal pressure range of 2.0-30.0 mmHg to determine their stress-strain behavior using an inverse analysis process...
June 8, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28592658/the-structural-response-of-the-cornea-to-changes-in-stromal-hydration
#15
Sally Hayes, Tomas White, Craig Boote, Christina S Kamma-Lorger, James Bell, Thomas Sorenson, Nick Terrill, Olga Shebanova, Keith M Meek
The primary aim of this study was to quantify the relationship between corneal structure and hydration in humans and pigs. X-ray scattering data were collected from human and porcine corneas equilibrated with polyethylene glycol (PEG) to varying levels of hydration, to obtain measurements of collagen fibril diameter, interfibrillar spacing (IFS) and intermolecular spacing. Both species showed a strong positive linear correlation between hydration and IFS(2) and a nonlinear, bi-phasic relationship between hydration and fibril diameter, whereby fibril diameter increased up to approximately physiological hydration, H = 3...
June 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28590790/the-effect-of-ascorbic-acid-vitamin-c-on-transepithelial-corneal-cross-linking-in-rabbits
#16
Mustafa Koc, Basak Bostanci, Ozlem Ozbas Demirel, Feyza Genc, Kemal Tekin, Yaran Koban, Aylin Sepici Dincel, Murat Sen, Pelin Yilmazbas
PURPOSE: To evaluate the effects of ascorbic acid (vitamin C), the main antioxidant agent in the cornea on transepithelial corneal cross-linking (CXL) where the main mechanism is oxidation. METHODS: Twenty eyes of 20 rabbits were divided into 3 groups: Group 1 (7 eyes) had transepithelial corneal CXL after being fed with normal diet; Group 2 (7 eyes) had corneal CXL after once-daily subcutaneous injections of 200 mg of ascorbic acid in addition to normal diet; and the control group (6 eyes) was fed with normal diet but did not have corneal CXL performed...
June 7, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28586502/biomechanical-changes-after-lasik-flap-creation-combined-with-rapid-cross-linking-measured-with-brillouin-microscopy
#17
J Bradley Randleman, Johnny P Su, Giuliano Scarcelli
PURPOSE: To evaluate the biomechanical changes occurring after LASIK flap creation and rapid corneal cross-linking (CXL) measured with Brillouin light microscopy. METHODS: Porcine eyes (n = 11) were evaluated by Brillouin light microscopy sequentially in the following order: virgin state, after LASIK flap creation, and after rapid CXL. Each eye served as its own control. Depth profile of the Brillouin frequency shift was computed to reveal the depth-dependent changes in corneal stiffness...
June 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28552439/sterile-infiltrates-after-cross-linking
#18
G García de Oteyza, J Álvarez de Toledo
CASE REPORT: A 20 year-old woman presented with an asymmetric bilateral keratoconus. Cross-linking of the right eye was performed due of its topographic and pachymetric conditions. Three days after the procedure, the patient presented with some corneal infiltrates that where classified as sterile. DISCUSSION: Cross-linking is known for its efficacy and safety. Nevertheless, there can be complications. Sterile infiltrates have already been described, although their aetiology is still not clear...
May 25, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28551428/delivery-of-riboflavin-5-monophosphate-into-the-cornea-can-liposomes-provide-any-enhancement-effects
#19
Neva Kandzija, Vitaliy V Khutoryanskiy
Keratoconus is a progressive condition caused by the thinning of the cornea, which eventually deforms the front surface of the eye into a cone shape leading to ghosting, multiple images, glare, and several other vision problems. Currently, keratoconus is treated with UV-induced riboflavin (Rb)-mediated collagen cross-linking, which requires a physical removal of the corneal epithelium under topical anesthesia. This study reports the penetration of Rb and its more water-soluble form, riboflavin-5'-monophosphate (RbP), into the bovine cornea ex vivo...
May 24, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28546941/role-of-corneal-collagen-fibrils-in-corneal-disorders-and-related-pathological-conditions
#20
REVIEW
Hong-Yan Zhou, Yan Cao, Jie Wu, Wen-Song Zhang
The cornea is a soft tissue located at the front of the eye with the principal function of transmitting and refracting light rays to precisely sense visual information. Corneal shape, refraction, and stromal stiffness are to a large part determined by corneal fibrils, the arrangements of which define the corneal cells and their functional behaviour. However, the modality and alignment of native corneal collagen lamellae are altered in various corneal pathological states such as infection, injury, keratoconus, corneal scar formation, and keratoprosthesis...
2017: International Journal of Ophthalmology
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