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corneal cross linking

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https://www.readbyqxmd.com/read/27930793/intracorneal-ring-segments-implantation-for-corneal-ectasia
#1
Natalia T Giacomin, Glauco R Mello, Carla S Medeiros, Alyin Kiliç, Cristine C Serpe, Hirlana G Almeida, Newton Kara-Junior, Marcony R Santhiago
PURPOSE: To provide an overview of the predictability, safety, and efficacy of intrastromal corneal ring segment (ICRS) implantation as a tool to improve visual acuity and its association with other techniques such as corneal collagen cross-linking (CXL), addressing biomechanical outcomes, models, surgical planning and technique, indications, contraindications, and complications in ectatic corneas. METHODS: Literature review. RESULTS: ICRSs have been used to regularize the corneal shape and reduce corneal astigmatism and higher order aberrations, improve visual acuity to acceptable limits, and delay, or eventually prevent, a corneal keratoplasty in keratoconic eyes...
December 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27930789/comparison-of-corneal-riboflavin-gradients-using-dextran-and-hpmc-solutions
#2
Tobias Ehmke, Theo G Seiler, Isaak Fischinger, Tammo Ripken, Alexander Heisterkamp, Beatrice E Frueh
PURPOSE: To determine the riboflavin concentration gradient in the anterior corneal stroma when using hydroxypropyl methylcellulose (HPMC) or dextran as the carrier agent. METHODS: Four different groups of porcine corneas (5 each) were compared regarding the riboflavin concentration in the anterior stroma. Prior to all experiments, stable hydration conditions were established for the corresponding solution. The dextran groups were treated with 0.1% riboflavin in 20% dextran for 10 and 30 minutes and the HPMC groups with 0...
December 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27918357/re-godefrooij-da-soeters-n-imhof-sm-wisse-rp-corneal-cross-linking-for-pediatric-keratoconus-long-term-results-cornea-2016-jul-35-7-954-8
#3
David OʼBrart, Nicholas Maycock
No abstract text is available yet for this article.
December 1, 2016: Cornea
https://www.readbyqxmd.com/read/27918352/corneal-collagen-cross-linking-for-keratoconus-in-pediatric-patients-long-term-results
#4
Prema Padmanabhan, Sudhir Rachapalle Reddi, Rama Rajagopal, Radhika Natarajan, Geetha Iyer, Bhaskar Srinivasan, Niveditha Narayanan, Meena Lakshmipathy, Shweta Agarwal
PURPOSE: To report the long-term outcome of corneal collagen cross-linking (CXL) for progressive keratoconus in pediatric patients. METHODS: "Epithelium-off" CXL was performed in pediatric eyes with progressive keratoconus. Spectacle-corrected distance visual acuity (CDVA), retinoscopy, topography, and tomography were documented preoperatively and postoperatively at 3 months, 6 months, 1 year, and annually thereafter. RESULTS: A total of 377 eyes of 336 pediatric patients aged 8 to 18 years with progressive keratoconus underwent CXL...
December 1, 2016: Cornea
https://www.readbyqxmd.com/read/27914659/corneal-collagen-cross-linking-a-review-of-its-clinical-applications
#5
K Balparda, M J Maldonado
OBJECTIVE: To perform a literature review of the current clinical applications of corneal collagen cross-linking. METHODS: An exhaustive literature search was made, including the main biomedical databases, and encompassing all years since the introduction of cross-linking in ophthalmology practice. RESULTS: Corneal collagen cross-linking using UVA irradiation and riboflavin is a surgical technique that is currently being optimised, and is supported by a good amount of pre-clinical and clinical studies...
November 30, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27910295/combined-application-of-prophylactic-corneal-cross-linking-and-laser-in-situ-keratomileusis-a-review-of-literature
#6
REVIEW
Tommy C Y Chan, Alex L K Ng, Karen K W Chan, George P M Cheng, Ian Y H Wong, Vishal Jhanji
Laser in-situ keratomileusis (LASIK) is safe and effective laser refractive procedures in treating refractive errors. However, regression of treatment and iatrogenic keratectasia remain to be a major concern, especially in treating thin cornea with high ametropia. Collagen cross-linking (CXL) is an effective method in stopping keratoconus progression through increasing the biomechanical strength of the cornea. Adjuvant cross-linking to refractive procedures can theoretically help prevent regression and reduce the risk of keratectasia development by increasing the mechanical stability of cornea...
December 2, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27900926/-corneal-cross-linking-as-a-treatment-for-progressive-keratoconus
#7
R P L Wisse, N Soeters, D A Godefrooij, N G de Koning-Tahzib
Keratoconus is a corneal disease with onset typically occurring during puberty or early adulthood. The cornea progressively thins and acquires a cone-like shape which negatively affects visual acuity. In the early stages, visual acuity can be corrected with glasses or contact lenses. In more advanced cases, a corneal transplant is ultimately indicated to restore visual acuity. Corneal cross-linking (CXL) is a treatment given at a relatively early stage that protects patients against deterioration of visual acuity and further corneal deformation in progressive cases of keratoconus...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27898982/evaluation-of-corneal-cross-linking-for-treatment-of-fungal-keratitis-using-confocal-laser-scanning-microscopy-on-an-ex-vivo-human-corneal-model
#8
Jawaher M Alshehri, David Caballero-Lima, M Chantal Hillarby, Susan G Shawcross, Arun Brahma, Fiona Carley, Nick D Read, Hema Radhakrishnan
Purpose: Some previous reports have established the use of photoactivated chromophore-induced corneal cross-linking (PACK-CXL) in treating fungal keratitis. The results of these case reports have often been conflicting. To systematically study the effect of PACK-CXL in the management of Fusarium keratitis, we have developed an ex vivo model of human corneal infection using eye-banked human corneas. Methods: Sixteen healthy ex vivo human corneas were divided into four study groups: (1) untreated control, (2) cross-linked, (3) infected with fungal spores, and (4) infected with fungal spores and then cross-linked...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27893524/visual-outcomes-after-smile-lasek-and-lasek-combined-with-corneal-collagen-cross-linking-for-high-myopic-correction
#9
Sangyoon Hyun, Seongjun Lee, Jae-Hyung Kim
PURPOSE: To compare the visual and refractive outcomes of small-incision lenticule extraction (SMILE), laser-assisted subepithelial keratomileusis (LASEK), and LASEK combined with corneal collagen cross-linking (LASEK-CXL) surgery for high-degree myopia. METHODS: Medical records of patients with spherical equivalent (SE) greater than -6.00 diopters (D) treated with SMILE, LASEK, and LASEK-CXL were reviewed. Uncorrected distance visual acuity (UCVA), SE, and corneal haze were followed up in the 3 groups for 6 months...
November 23, 2016: Cornea
https://www.readbyqxmd.com/read/27892757/basic-principles-and-current-status-of-transcorneal-and-transscleral-iontophoresis
#10
Taís Gratieri, Verena Santer, Yogeshvar N Kalia
Iontophoresis is an active non-invasive drug delivery technique that can increase the transport of charged and neutral molecules into and across biological membranes. Most research to-date has focused on (per)cutaneous iontophoretic drug delivery. However, recent studies illustrate its potential for drug delivery to the eye: corneal iontophoresis may enable targeted topical therapy of intracorneal diseases, whereas transscleral iontophoresis may enable non-invasive intraocular drug delivery. Areas covered: We describe iontophoretic principles in the context of ocular delivery before providing a summary of recent preclinical studies involving transcorneal and transscleral iontophoresis in vitro and in vivo...
November 28, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27882004/efficacy-and-safety-of-transepithelial-collagen-cross-linking-for-progressive-keratoconus
#11
Sameer Shahid Ameen, Mohammad Asim Mehboob, Kashif Ali
OBJECTIVE: To evaluate the efficacy and safety of transepithelial (TE) collagen cross-linking (CXL) in patients with progressive keratoconus (KC). METHODS: This Quasi Experimental Study was conducted at PNS Shifa Naval Hospital, Karachi from June 2015 to June 2016. Sixty eyes of 32 patients who underwent TE CXL for progressive KC from June 2015 to June 2016 were analysed to ascertain efficacy and safety of TE CXL procedure. Statistical analysis of the data was done using SPSS version 17...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27861308/ocular-surface-disease-parameters-after-collagen-cross-linking-for-keratoconus
#12
José I Recalde, Arantxa Acera, Iñaki Rodríguez-Agirretxe, Miguel A Sánchez-Tena, Juan San-Cristóbal, Juan A Durán
PURPOSE: To analyze the variations in tear quantity and quality after corneal collagen cross-linking (CXL) in patients with keratoconus. METHODS: This is a prospective observational study of 24 eyes with keratoconus that underwent epithelium-off CXL. The variables studied were tear film osmolarity, subjective symptoms (Ocular Surface Disease Index), tear breakup time, Schirmer test (SCH) score, tear clearance, fluorescein staining, and lissamine green staining. Variables were determined preoperatively and 3, 6, and 12 months after CXL...
November 16, 2016: Cornea
https://www.readbyqxmd.com/read/27815790/keratoconus-and-other-corneal-diseases-pharmacologic-cross-linking-and-future-therapy
#13
Kimberly M Hsu, Joel Sugar
The ability to cross-link collagen fibers and use this technique to strengthen the cornea has become of great interest to ophthalmologists in the last decade. For progressive diseases such as keratoconus, collagen cross-linking confers the possibility of halting progression and stabilizing the cornea, a benefit that is not observed with any other current treatment. Collagen cross-linking uses riboflavin combined with ultraviolet A light to induce the formation of bonds between collagen fibrils that strengthen the cornea...
November 5, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27781383/topographic-tomographic-and-biomechanical-corneal-changes-during-pregnancy-in-patients-with-keratoconus-a-cohort-study
#14
Mohammad Naderan, Ali Jahanrad
PURPOSE: This study aimed at evaluating the effect of pregnancy on topographic, tomographic and biomechanical parameters of patients with keratoconus (KC) in comparison with non-pregnant patients with KC. METHOD: In a cohort study, patients with KC, whose disease was stable for at least 2 years, were evaluated before pregnancy, at their third trimester of pregnancy (34th week of pregnancy) and 6 months after pregnancy. As the control group, an equivalent number of age- and severity-matched non-pregnant female patients with KC were evaluated at the corresponding times...
October 26, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27775234/sterile-corneal-infiltrates-after-corneal-collagen-cross-linking-evaluation-of-risk-factors
#15
Eren Çerman, Deniz Özarslan Özcan, Ebru Toker
PURPOSE: To evaluate possible risk factors leading to sterile corneal infiltrates following corneal collagen cross-linking (CXL). METHODS: A total of 588 eyes of 459 patients treated with Epi-off (n = 461) or Epi-on (n = 127) CXL were retrospectively evaluated. Risk factors, including preoperative blepharitis and vernal conjunctivitis, the postoperative use of topical non-steroidal anti-inflammatory drugs (NSAIDs), as well as Kmax and pachymetry measurements, were assessed...
October 24, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27772645/corneal-cross-linking-for-keratoconus-a-look-at-the-data-the-food-and-drug-administration-and-the-future
#16
Bennie H Jeng, Marjan Farid, Sanjay V Patel, Ivan R Schwab
No abstract text is available yet for this article.
November 2016: Ophthalmology
https://www.readbyqxmd.com/read/27765574/an-investigation-into-corneal-enzymatic-resistance-following-epithelium-off-and-epithelium-on-corneal-cross-linking-protocols
#17
Nada H Aldahlawi, Sally Hayes, David P S O'Brart, Naomi D O'Brart, Keith M Meek
The aim of this study was to investigate corneal enzymatic resistance following epithelium off and on riboflavin/UVA cross-linking (CXL). One hundred and fourteen porcine eyes were divided into four non-irradiated control groups and seven CXL groups. The latter comprised; (i) epithelium-off, 0.1% iso-osmolar riboflavin, 9 mW UVA irradiation for 10 min, (ii) disrupted epithelium, 0.1% hypo-osmolar riboflavin, 9 mW UVA for 10 min, (iii) epithelium-on, 0.25% hypo-osmolar riboflavin with 0.01% benzylalkonium chloride (BACS), 9 mW UVA for 10 min, (iv) epithelium-on, 5 min iontophoresis at 0...
December 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27757009/corneal-endothelial-changes-after-accelerated-corneal-collagen-cross-linking-in-keratoconus-and-postlasik-ectasia
#18
Amani E Badawi
PURPOSE: The purpose of this study was to evaluate the effects of accelerated cross-linking (CXL) on corneal endothelium in keratoconus and postlaser-assisted in situ keratomileusis (LASIK) ectasia. DESIGN: This study is a prospective nonrandomized controlled study. SETTING: This study was conducted in Mansoura Ophthalmic Center (Mansoura University) and Al-Mostakbal Ophthalmic Center, Mansoura, Egypt. METHODS: In total, 40 eyes with progressive keratoconus and 10 eyes with postLASIK ectasia were subjected to an accelerated CXL (10 mW/cm(2) for 9 minutes)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27755188/matrix-based-regenerating-agent-for-corneal-wound-healing-after-collagen-cross-linking
#19
Marina Hovakimyan, Oliver Stachs, Olmiere Céline, Rudolf F Guthoff
PURPOSE: Corneal collagen cross-linking (CXL) is associated with massive cellular damage, the long-term clinical consequences of which have still to be elucidated. In this study, we seek to determine whether matrix-based regenerating agent (RGTA) therapy has a positive influence on stromal regeneration after CXL. METHODS: Twelve New Zealand white rabbits were randomly divided into 2 groups of 6. CXL of the right cornea was performed in both groups, followed by topical corneal application of one drop of vehicle or one drop of RGTA...
October 14, 2016: Cornea
https://www.readbyqxmd.com/read/27749500/objective-and-subjective-outcome-of-clear-lensectomy-with-toric-iol-implantation-after-corneal-collagen-cross-linking-in-selected-cases-of-keratoconus
#20
Waleed Ali Abou Samra, Eman Azmy Awad, Amr Hassan El Kannishy
AIM: To evaluate the visual and topographic outcomes of a two-stage approach treatment for selected cases of progressive keratoconus (KC); corneal collagen cross-linking (CXL) followed by phacoemulsification with toric intraocular lens (IOL) implantation. METHODS: The study included 9 eyes of 6 patients diagnosed with progressive KC, aged from 35 to 47 years (41.6±11.2 years). All studied eyes underwent a two-stage approach treatment: first corneal collagen CXL followed after at least 6 months by phacoemulsification with foldable toric IOL implantation in both eyes of three patients and only one eye of the other three patients...
October 3, 2016: Eye & Contact Lens
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