keyword
https://read.qxmd.com/read/38492463/characterization-and-classification-of-oleogels-and-edible-oil-using-vibrational-spectroscopy-in-tandem-with-one-class-and-multiclass-chemometric-methods
#21
JOURNAL ARTICLE
Ingrid A Moraes, Marina G Neves, Heinz W Siesler, Javier E L Villa, Rosiane L Cunha, Douglas F Barbin
Oleogel represents a promising healthier alternative to act as a substitute for conventional fat in various food products. Oil selection is a crucial factor in determining the technological properties and applications of oleogels due to their distinct fatty acid composition, molecular weight, and thermal properties, as well as the presence of antioxidants and oxidative stability. Hence, the relevance of monitoring oleogel properties by non-destructive, eco-friendly, portable, fast, and effective techniques is a relevant task and constitutes an advance in the evaluation of oleogels quality...
March 11, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/38492462/a-novel-dual-color-fluorescent-sensor-with-two-pkas-for-on-site-detection-of-ph-in-food
#22
JOURNAL ARTICLE
Yutian Zhao, Shiwei Zhang, Na Li, Weihua Deng, Mingle Li, Tianyi Qin, Lei Wang, Zhongyong Xu, Bin Liu
Tracking pH fluctuations in food samples is important for ensuring food freshness. Fluorescent probes have been widely applied as promising tools for the on-site detection of pH changes; however, most of them can be applied only at either lower or higher pH ranges because their response structures commonly have a single acid dissociation constant (pKa). To address this problem, we designed a fluorescent sensor, called HMB, containing a methylpiperazine group with two pKa values, which exhibited a unique dual-color response to pH changes over a wide pH range...
March 13, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/38492290/novel-approach-over-template-molecule-elimination-in-molecularly-imprinted-polymers-by-using-heat-activated-persulfate
#23
JOURNAL ARTICLE
Juan I Calbanese, Mario D Contin, Pablo R Bonelli, Ana L Cukierman, Valeria P Tripodi
This study proposes a new alternative for template removal from molecularly imprinted polymers by heat activated persulfate. It is known that trace amounts of template molecule remains in the polymer network after extraction by current methodologies leading to bleeding and incomplete removal of template which could compromise final determination of target analytes especially in trace analysis. A previously developed molecularly imprinted polymer specially designed for Coenzyme Q10 (CoQ10 ) extraction was employed as a model to test this template elimination approach...
March 1, 2024: Journal of Chromatography. A
https://read.qxmd.com/read/38492241/propionic-acid-affects-the-synaptic-architecture-of-rat-hippocampus-and-prefrontal-cortex
#24
JOURNAL ARTICLE
Mzia G Zhvania, Giorgi Lobzhanidze, Nino Pochkhidze, Nadezhda Japaridze, Pavel Tchelidze, Fuad Rzayev, Eldar Gasimov
It is well documented that propionic acid (PPA) produces behavioral, morphological, molecular and immune responses in rats that are characteristic of autism spectrum disorder in humans. However, whether PPA affects the ultrastructure and synaptic architecture of regions of autistic brain has not been adequately addressed. Earlier we show that single intraperitoneal (IP) injection of PPA (175 mg/kg) produces superficial changes in the spatial memory and learning of adolescent male Wistar rats. However, in neurons, synapses and glial cells of hippocampal CA1 area and medial prefrontal cortex transient (mainly) or enduring alterations were detected...
March 4, 2024: Micron
https://read.qxmd.com/read/38492200/evaluation-of-the-pathogenic-potential-of-germline-ddx41-variants-in-hematopoietic-neoplasms-using-the-acmg-amp-guidelines
#25
JOURNAL ARTICLE
Hirotaka Matsui, Makoto Hirata
Clinical use of gene panel testing for hematopoietic neoplasms in areas, such as diagnosis, prognosis prediction, and exploration of treatment options, has increased in recent years. The keys to interpreting gene variants detected in gene panel testing are to distinguish between germline and somatic variants and accurately determine whether the detected variants are pathogenic. If a variant is suspected to be a pathogenic germline variant, it is essential to confirm its consistency with the disease phenotype and gather a thorough family history...
March 16, 2024: International Journal of Hematology
https://read.qxmd.com/read/38492187/molecular-structural-and-functional-diversity-of-universal-stress-proteins-usps-in-bacteria-plants-and-their-biotechnological-applications
#26
REVIEW
Bilkees Nabi, Manoj Kumawat, Neeraj Ahlawat, Sushma Ahlawat
Universal stress proteins (USPs) are widely distributed and play crucial roles in cellular responses to biotic and abiotic stresses. These roles include regulating cell growth and development, cell motility, hypoxia responses, and ion sequestration. With the increasing frequency and intensity of extreme weather events due to climate change, pathogens have developed different strategies to withstand environmental stresses, in which USPs play a significant role in their survival and virulence. In this study, we analyzed the importance of USPs in various organisms, such as archaea, plants, and fungi, as a parameter that influences their survival...
March 16, 2024: Protein Journal
https://read.qxmd.com/read/38492111/treatment-intensification-strategies-for-men-undergoing-definitive-radiotherapy-for-high-risk-prostate-cancer
#27
REVIEW
John Nikitas, Amar Kishan, Albert Chang, Sai Duriseti, Nicholas G Nichols, Robert Reiter, Matthew Rettig, Wayne Brisbane, Michael L Steinberg, Luca Valle
PURPOSE: Treatment intensification of external beam radiotherapy (EBRT) plays a crucial role in the treatment of high-risk prostate cancer. METHODS: We performed a critical narrative review of the relevant literature and present new developments in evidence-based treatment intensification strategies. RESULTS: For men with high-risk prostate cancer, there is strong evidence to support prolonging androgen deprivation therapy (ADT) to 18-36 months and escalating the dose to the prostate using a brachytherapy boost...
March 16, 2024: World Journal of Urology
https://read.qxmd.com/read/38492042/transcriptomic-contributions-to-a-modern-cytoarchitectonic-parcellation-of-the-human-cerebral-cortex
#28
JOURNAL ARTICLE
Leana King, Kevin S Weiner
Transcriptomic contributions to the anatomical, functional, and network layout of the human cerebral cortex (HCC) have become a major interest in cognitive and systems neuroscience. Here, we tested if transcriptomic differences support a modern, algorithmic cytoarchitectonic parcellation of HCC. Using a data-driven approach, we identified a sparse subset of genes that differentially contributed to the cytoarchitectonic parcellation of HCC. A combined metric of cortical thickness and myelination (CT/M ratio), as well as cell density, correlated with gene expression...
March 16, 2024: Brain Structure & Function
https://read.qxmd.com/read/38492039/multicenter-evaluation-of-an-automated-multiplex-rna-based-molecular-assay-for-detection-of-alk-ros1-ret-fusions-and-met-exon-14-skipping-in-nsclc
#29
JOURNAL ARTICLE
Melchior Linea, Hirschmann Astrid, Hofman Paul, Bontoux Christophe, Concha Angel, Mrabet-Dahbi Salima, Vannuffel Pascal, Watkin Emmanuel, Putzová Martina, Scarpino Stefania, Cayre Anne, Martin Paloma, Stoehr Robert, Hartmann Arndt
The current study assessed the performance of the fully automated RT-PCR-based Idylla™ GeneFusion Assay, which simultaneously covers the advanced non-small cell lung carcinoma (aNSCLC) actionable ALK, ROS1, RET, and MET exon 14 rearrangements, in a routine clinical setting involving 12 European clinical centers. The Idylla™ GeneFusion Assay detects fusions using fusion-specific as well as expression imbalance detection, the latter enabling detection of uncommon fusions not covered by fusion-specific assays...
March 16, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38491967/age-dependent-changes-in-collagen-crosslinks-reduce-the-mechanical-toughness-of-human-meniscus
#30
JOURNAL ARTICLE
Derek Q Nesbitt, Xinzhu Pu, Matthew W Turner, Anamaria G Zavala, Laura Bond, Julia T Oxford, Trevor J Lujan
The mechanical resilience of the knee meniscus is provided by a group of structural proteins in the extracellular matrix. Aging can alter the quantity and molecular structure of these proteins making the meniscus more susceptible to debilitating tears. In this study, we determined the effect of aging on the quantity of structural proteins and collagen crosslinks in human lateral meniscus, and examined whether the quantity of these molecules was predictive of tensile toughness (area under the stress-strain curve)...
March 16, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38491773/subset-based-method-for-cross-tissue-transcriptome-wide-association-studies-improves-power-and-interpretability
#31
JOURNAL ARTICLE
Xinyu Guo, Nilanjan Chatterjee, Diptavo Dutta
Integrating results from genome-wide association studies (GWAS) and studies of molecular phenotypes like gene expressions, can improve our understanding of the biological functions of trait-associated variants, and can help prioritize candidate genes for downstream analysis. Using reference expression quantitative trait loci (eQTL) studies, several methods have been proposed to identify gene-trait associations, primarily based on gene expression imputation. To increase the statistical power by leveraging substantial eQTL-sharing across tissues, meta-analysis methods aggregating such gene-based test results across multiple tissues or contexts have been developed as well...
March 14, 2024: HGG advances
https://read.qxmd.com/read/38491772/testing-the-feasibility-of-targeting-a-conserved-region-on-the-s2-domain-of-the-sars-cov-2-spike-protein
#32
JOURNAL ARTICLE
Pranav Garg, Shawn C C Hsueh, Steven S Plotkin
The efficacy of vaccines against the SARS-CoV-2 virus significantly declines with the emergence of mutant strains, prompting investigation into the feasibility of targeting highly conserved but often cryptic regions on the S2 domain of spike protein. Using tools from molecular dynamics, we find that exposure of this conserved S2 epitope located in the central helices below the receptor binding domains would require large-scale motion beyond RBD up-down motion, but, along the reaction coordinates we explored, it is unlikely to be exposed by such large-scale dynamic fluctuations of the S1 domain without any external facilitating factors, in spite of some previous computational evidence suggesting transient exposure of this region...
March 14, 2024: Biophysical Journal
https://read.qxmd.com/read/38491750/editor-spotlight-interview-with-cholinergic-mechanisms-special-issue-guest-editor-hermona-soreq
#33
EDITORIAL
Kim H Kwan, Hermona Soreq
Hermona Soreq holds a Hebrew University Slesinger Chair in Molecular Neuroscience and is among the founding members of the Edmond and Lily Safra Center of Brain Sciences (ELSC). Soreq's research (H-impact: 98) focuses on acetylcholine (ACh)-related pathways and combines RNA-sequencing technologies, transgenic engineering, and molecular biology tests with in-depth analysis approaches. Her work addresses microRNAs (miRs) and transfer RNA fragments (tRFs) which have rapidly acquired wide recognition as global controllers of regulatory processes in healthy and diseased brain and body, including anxiety, inflammation, and cognition...
March 15, 2024: Journal of Neurochemistry
https://read.qxmd.com/read/38491416/poly-%C3%AF%C2%B5-caprolactone-scaffold-as-staple-line-reinforcement-of-rectal-anastomosis-an-experimental-piglet-study
#34
JOURNAL ARTICLE
Laura Lovisa Køtlum Petersen, Martin Dennis Dursun, Gunvor Madsen, Dang Quang Svend Le, Sören Möller, Niels Qvist, Mark Bremholm Ellebæk
PURPOSE: Rectal anastomoses have a persisting high incidence of anastomotic leakage. This study aimed to assess whether the use of a poly-ϵ-caprolactone (PCL) scaffold as reinforcement of a circular stapled rectal anastomosis could increase tensile strength and improve healing compared to a control in a piglet model. METHOD: Twenty weaned female piglets received a stapled rectal anastomosis and were randomised to either reinforcement with PCL scaffold (intervention) or no reinforcement (control)...
March 15, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38491414/high-prevalence-of-st5-sccmec-ii-t311-clone-of-methicillin-resistant-staphylococcus-aureus-isolated-from-bloodstream-infections-in-east-china
#35
JOURNAL ARTICLE
Qing Zhan, Gaoqin Teng, Weiwei Chen, Xiao Yu
OBJECTIVES: Methicillin-resistant Staphylococcus aureus (MRSA) is a challenging global health threat, resulting in significant morbidity and mortality worldwide. This study aims to determine the molecular characteristics and antimicrobial susceptibility of 263 MRSA isolates in Zhejiang Province, east China. METHODS: From 2014 to 2019, a total of 263 MRSA isolates from bloodstream infections (BSIs) were collected from 6 hospitals in 4 cities in Zhejiang province, east China...
March 16, 2024: BMC Microbiology
https://read.qxmd.com/read/38491393/long-term-high-fat-diet-consumption-aggravates-%C3%AE-amyloid-deposition-and-tau-pathology-accompanied-by-microglial-activation-in-an-alzheimer-s-disease-model
#36
JOURNAL ARTICLE
Zheng Liang, Xiaokang Gong, Yang Zhao, Yanna Zhao, Jing Yu, Tiantian Huang, Chaoqing Yang, Liangwei Wu, Mengbing Huang, Xiaochuan Wang, Xiji Shu, Jian Bao
Alzheimer's disease (AD) is the most prevailing form of dementia, with long-term high-fat diet (HFD) consumption being a pivotal contributor to AD pathogenesis. As microglial dysfunction is a crucial factor in the AD onset, it becomes imperative to explore the effects of HFD on microglial function and AD pathogenesis. In the present study, 3xTg-AD model mice at the age of 9-month are subjected to random allocation, with one group receiving a standard diet (ND) and the other an HFD for 3 months. Subsequently, transcriptomic profiling of microglia unveils that HFD alters fatty acid metabolism and mediates T cell infiltration...
March 15, 2024: Molecular Nutrition & Food Research
https://read.qxmd.com/read/38491354/association-of-lymphocyte-subsets-with-the-efficacy-and-prognosis-of-pd%C3%A2-1-inhibitor-therapy-in-advanced-gastric-cancer-results-from-a-monocentric-retrospective-study
#37
JOURNAL ARTICLE
Xinyan Wang, Xiaoling Liu, Huwei Dai, Junmei Jia
PURPOSE: This retrospective study aimed to investigate the changes in peripheral blood lymphocyte subsets before and after immunotherapy in patients with advanced gastric cancer and their relationship n with the therapeutic efficacy and clinical prognosis. METHODS: Peripheral blood lymphocyte subsets, including CD4 + T cells, CD8 + T cells, CD4+/CD8 + ratio, NK cells, Treg cells, and B cells, were collected from 195 patients with advanced gastric cancer who were admitted to the First Hospital of Shanxi Medical University with immunotherapy from January 2020 to October 2021, at the time of diagnosis of advanced gastric cancer, before immunotherapy and after 3 cycles of immunotherapy...
March 15, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38491346/the-relationship-between-sarcopenia-and-metabolic-dysfunction-associated-fatty-liver-disease-among-the-young-and-middle-aged-populations
#38
JOURNAL ARTICLE
Ziyan Feng, Fanrong Zhao, Ziyao Wang, Xinyi Tang, Yan Xie, Li Qiu
BACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed as a new term for diagnosing fatty liver disease, which is considered to be a multi-systemic disease with multiple extrahepatic manifestations, including sarcopenia. The link between sarcopenia and MAFLD remains uncertain, especially among young and middle-aged adults. Thus, we examined the relationship between MAFLD and sarcopenia in young and middle-aged individuals in this study. METHODS: A total of 2214 individuals with laboratory tests, dual-energy X-ray absorptiometry and ultrasound transient elastography from NHANES 2017-2018 were selected for this study...
March 15, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38491343/association-of-neurotransmitter-pathway-polygenic-risk-with-specific-symptom-profiles-in-psychosis
#39
JOURNAL ARTICLE
Tracy L Warren, Justin D Tubbs, Tyler A Lesh, Mylena B Corona, Sarvenaz S Pakzad, Marina D Albuquerque, Praveena Singh, Vanessa Zarubin, Sarah J Morse, Pak Chung Sham, Cameron S Carter, Alex S Nord
A primary goal of psychiatry is to better understand the pathways that link genetic risk to psychiatric symptoms. Here, we tested association of diagnosis and endophenotypes with overall and neurotransmitter pathway-specific polygenic risk in patients with early-stage psychosis. Subjects included 205 demographically diverse cases with a psychotic disorder who underwent comprehensive psychiatric and neurological phenotyping and 115 matched controls. Following genotyping, we calculated polygenic scores (PGSs) for schizophrenia (SZ) and bipolar disorder (BP) using Psychiatric Genomics Consortium GWAS summary statistics...
March 15, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38491248/epdrna-a-model-for-identifying-dna-rna-binding-sites-in-disease-related-proteins
#40
JOURNAL ARTICLE
CanZhuang Sun, YongE Feng
Protein-DNA and protein-RNA interactions are involved in many biological processes and regulate many cellular functions. Moreover, they are related to many human diseases. To understand the molecular mechanism of protein-DNA binding and protein-RNA binding, it is important to identify which residues in the protein sequence bind to DNA and RNA. At present, there are few methods for specifically identifying the binding sites of disease-related protein-DNA and protein-RNA. In this study, so we combined four machine learning algorithms into an ensemble classifier (EPDRNA) to predict DNA and RNA binding sites in disease-related proteins...
March 16, 2024: Protein Journal
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