keyword
https://read.qxmd.com/read/38498078/insights-into-the-epidemiology-pathogenesis-and-differential-diagnosis-of-schistosomiasis
#1
REVIEW
Elena Ponzo, Angelina Midiri, Andrea Manno, Martina Pastorello, Carmelo Biondo, Giuseppe Mancuso
Schistosomiasis is a neglected tropical disease that is prevalent in low- and middle-income countries. There are five human pathogenic species, of which Schistosoma haematobium, Schistosoma mansoni and Schistosoma japonicum are the most prevalent worldwide and cause the greatest burden of disease in terms of mortality and morbidity. In addition, hybrid schistosomes have been identified through molecular analysis. Human infection occurs when cercariae, the larval form of the parasite, penetrate the skin of people while bathing in contaminated waters such as lakes and rivers...
March 18, 2024: European Journal of Microbiology & Immunology
https://read.qxmd.com/read/38498059/combination-treatment-of-zinc-and-selenium-intervention-ameliorated-bpa-exposed-germ-cell-damage-in-sd-rats-elucidation-of-molecular-mechanisms
#2
JOURNAL ARTICLE
Chittaranjan Sahu, Gopabandhu Jena
Bisphenol A (BPA) is a commonly used environmental toxicant, is easily exposed to the human body and causes testicular damage, sperm abnormalities, DNA damage and apoptosis, and interferes in the process spermatogenesis and steroidal hormone production along with obstruction in testes and epididymis development. Zinc (Zn), a potent regulator of antioxidant balance, is responsible for cellular homeostasis, enzymes and proteins activities during spermatogenesis for cell defence mechanisms in the testes. Selenium (Se) is required for spermatogenesis, antioxidant action and in the activities of different selenoproteins...
March 18, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38498003/enhancing-multi-species-liver-microsomal-stability-prediction-through-artificial-intelligence
#3
JOURNAL ARTICLE
Teng-Zhi Long, De-Jun Jiang, Shao-Hua Shi, You-Chao Deng, Wen-Xuan Wang, Dong-Sheng Cao
Liver microsomal stability, a crucial aspect of metabolic stability, significantly impacts practical drug discovery. However, current models for predicting liver microsomal stability are based on limited molecular information from a single species. To address this limitation, we constructed the largest public database of compounds from three common species: human, rat, and mouse. Subsequently, we developed a series of classification models using both traditional descriptor-based and classic graph-based machine learning (ML) algorithms...
March 18, 2024: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/38497839/clinical-and-laboratory-diagnosis-of-mayaro-virus-mayv-current-status-and-opportunities-for-further-development
#4
REVIEW
Severino Jefferson Ribeiro da Silva, Larissa Krokovsky
The recent outbreaks related to Mayaro virus (MAYV) infection in the Americas have brought this neglected virus as a potential threat to global public health. Given the range of symptoms that can be associated with MAYV infection, it can be challenging to diagnose individuals based on clinical signs, especially in countries with simultaneous circulation of other mosquito-borne viruses, such as dengue virus (DENV) and chikungunya virus (CHIKV). With this challenge in mind, laboratory-based diagnosis assumes a critical role in the introduction of measures to help prevent virus dissemination and to adequately treat patients...
March 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38497770/computational-choreography-dissecting-the-dance-of-hydrogen-bonding-and-%C3%AF-%C3%AF-stacking-in-the-fluorescence-discrimination-mechanism-of-ciprofloxacin-with-supramolecular-assembly
#5
JOURNAL ARTICLE
Jaymin Parikh, Keyur Bhatt, Krunal Modi, Ajay Desai, Nihal Patel, Chirag Patel, Ravibhai Bhola
The detailed binding insight between the fluorophore and analyte plays a pivotal role in the design of an efficient chemosensor for water pollution. In this study, we designed a picolinic acid-functionalized calix[4]pyrrole ligand (PCACP). When testing out the fluorescence study with selected antibiotics, we observed remarkable enhancement of fluorescence spectra in the presence of ciprofloxacin, singling out the PCACP_Ciprofloxacin complex. The detailed binding mechanism is explored via computational methods including molecular docking and dynamics, DFT (density functional theory) and NBO (Natural Bonding Orbital) analysis...
March 18, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38497718/application-of-the-heavy-atom-effect-for-sub-microsecond-thermally-activated-delayed-fluorescence-and-an-all-organic-light-emitting-device-with-low-efficiency-roll-off
#6
JOURNAL ARTICLE
Michał Mońka, Szymon Gogoc, Karol Kozakiewicz, Vladyslav Ievtukhov, Daria Grzywacz, Olga Ciupak, Aleksander Kubicki, Piotr Bojarski, Przemysław Data, Illia E Serdiuk
The feature of abundant and environmentally friendly heavy atoms (HAs) like bromine to accelerate spin-forbidden transitions in organic molecules has been known for years. In combination with the easiness of incorporation, bromine derivatives of organic emitters showing thermally activated delayed fluorescence (TADF) emerge as a cheap and efficient solution for the slow reverse intersystem crossing (rISC) problem in such emitters and strong efficiency roll-off of all-organic light-emitting diodes (OLEDs). Here, we present a comprehensive photophysical study of a tri-PXZ-TRZ emitter reported previously and its hexabromo derivative showing a remarkable enhancement of rISC of up to 9 times and a short lifetime of delayed fluorescence of 2 μs...
March 18, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38497582/chronic-social-defeat-stress-induces-the-down-regulation-of-the-nedd4l-glt-1-ubiquitination-pathway-in-the-prefrontal-cortex-of-mice
#7
JOURNAL ARTICLE
Aika Kosuge, Kazuo Kunisawa, Tsubasa Iida, Bolati Wulaer, Tomoki Kawai, Moeka Tanabe, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri
Stressful life events contribute to the onset of major depressive disorder (MDD). We recently demonstrated abnormalities in ubiquitination in the pathophysiology of MDD. However, the underlying molecular mechanisms remain unclear. We investigated the involvement of the ubiquitination system-mediated glutamatergic dysfunction in social impairment induced by chronic social defeat stress (CSDS). Adult C57BL/6J mice were exposed to aggressor ICR male mice for 10 consecutive days. Social impairment was induced by CSDS in the social interaction test 1 days after the last stress exposure...
March 18, 2024: Journal of Neurochemistry
https://read.qxmd.com/read/38497294/multiple-integrated-computational-approach-to-analyse-wound-healing-potential-of-symplocos-racemosa-bark-as-matrix-metalloproteinase-inhibitors
#8
JOURNAL ARTICLE
Hafiz Abdul Rafey, Adnan Amin, Samir Anis Ross, Mohamed El-Shazly, Muhammad Ammar Zahid, Shah Iram Niaz, Fakhar Ul Mahmood, Hammad Ullah
The healing of wounds is the flagging concern in chronic wound cases especially when accompanied by pathogenic, diabetic comorbidities. Matrix metalloproteinases are associated with widespread pathological ailments, and the selective inhibitors for metalloproteinases can be of great interest in wound healing strategies. In the present research study, six constituents of Symplocos racemosa Roxb were evaluated for the docking aptitudes on human matrix metalloproteinase MMP 2 (PDB ID: 1QIB) and MMP 9 (PDB ID: 4H1Q) utilising Autodock Vina followed by the visualisation using Discovery studio (DS)...
March 18, 2024: Natural Product Research
https://read.qxmd.com/read/38497260/understanding-the-factors-regulating-host-microbiome-interactions-using-caenorhabditis-elegans
#9
REVIEW
Anupama Singh, Robert J Luallen
The Human Microbiome Project was a research programme that successfully identified associations between microbial species and healthy or diseased individuals. However, a major challenge identified was the absence of model systems for studying host-microbiome interactions, which would increase our capacity to uncover molecular interactions, understand organ-specificity and discover new microbiome-altering health interventions. Caenorhabditis elegans has been a pioneering model organism for over 70 years but was largely studied in the absence of a microbiome...
May 6, 2024: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://read.qxmd.com/read/38497199/design-synthesis-and-biological-evaluation-of-quinazoline-and-pyrrolo-3-2-d-pyrimidine-derivatives-as-tlr7-agonists-for-antiviral-agents
#10
JOURNAL ARTICLE
Yue Song, Wenjie Fan, Chen Yao, Heng Wang, Xiuxiang Lu, Yumin Wang, Pengxiang Liu, Yanjie Ma, Zhen Zhang, Jiang Wang, BeiBei Chu, Lijun Shi, Guoyu Yang, Mengdi Wang
Pattern recognition receptors (PRRs) play a critical role in the innate immune response, and toll-like receptor 7 (TLR7) is an important member of PRRs. Although several TLR7 agonists are available, most of them are being tested clinically, with only one available on the market. Thus, it is imperative to develop new TLR7 agonists. In this study, we designed and synthesized three kinds of quinazoline derivatives and five kinds of pyrrolo[3,2- d ]pyrimidine derivatives targeting TLR7. The antiviral efficacy of these compounds was evaluated in vitro and in vivo ...
March 18, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38496968/cellulolytic-and-ethanologenic-evaluation-of-heterotermes-indicola-s-gut-associated-bacterial-isolates
#11
JOURNAL ARTICLE
Sana Azhar, Ayesha Aihetasham, Asma Chaudhary, Zawar Hussain, Rahat Abdul Rehman, Ghulam Abbas, Sulaiman Ali Alharbi, Mohammad Javed Ansari, Samina Qamer
Cellulose is the basic component of lignocellulosic biomass (LCB) making it a suitable substrate for bioethanol fermentation. Cellulolytic and ethanologenic bacteria possess cellulases that convert cellulose to glucose, which in turn yields ethanol subsequently. Heterotermes indicola is a subterranean termite that causes destructive damage by consuming wooden structures of infrastructure, LCB products, etc. Prospectively, the study envisioned the screening of cellulolytic and ethanologenic bacteria from the termite gut...
March 12, 2024: ACS Omega
https://read.qxmd.com/read/38496935/biological-activities-of-galanthus-fosteri-extracts-first-demonstration-of-the-interaction-between-chlorogenic-acid-and-dna-ligase-by-molecular-docking
#12
JOURNAL ARTICLE
Safiye Elif Korcan, Nevin Çankaya, İbrahim Bulduk, Gencer Güvercin, Şah İsmail Çivi
Within the Amaryllidaceae family, the bulbous plant species Galanthus fosteri ( G. fosteri ) belongs to the Galanthus genus. Alkaloids with a broad variety of biological functions are typically found in the flora of this family. The G. fosteri plant's organs' antioxidant activity, antibacterial impact, and antimicrobial qualities were examined in this study. Total flavonoid contents (TFC) and total phenolic contents (TPC) of plant extracts were measured with spectrophotometric methods, and antioxidant activity was determined using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging technique...
March 12, 2024: ACS Omega
https://read.qxmd.com/read/38496823/clinical-validation-of-the-proenkephalin-penk-methylation-urine-test-for-monitoring-recurrence-of-non-muscle-invasive-bladder-cancer
#13
JOURNAL ARTICLE
Hyunho Han, Tae Jeong Oh, Ji Eun Heo, Jongsoo Lee, Won Sik Jang, Seung Hwan Lee, Won Sik Ham, Jaehee Hwang, Sungwhan An, Young-Deuk Choi
BACKGROUND AND OBJECTIVE: To assess the effectiveness of a urine-based proenkephalin ( PENK) methylation test using linear target enrichment-quantitative methylation-specific polymerase chain reaction (me PENK test) for detection of non-muscle-invasive bladder cancer (NMIBC) recurrence compared to cytology and the NMP22 test. METHODS: We first conducted a retrospective case-control study involving 54 patients with primary BC and 29 healthy individuals. We then prospectively enrolled 186 patients (January to December 2022) undergoing cystoscopy surveillance after transurethral resection of bladder tumor, of whom 59 had recurrent tumors...
April 2024: European urology open science
https://read.qxmd.com/read/38496820/a-genomic-urine-assay-for-surveillance-of-patients-with-bladder-cancer-treated-with-radiotherapy
#14
JOURNAL ARTICLE
Florus C de Jong, Iris G Iflé, Angelique C van der Made, Denise Kooper, Joep J de Jong, Martine Franckena, Tahlita C M Zuiverloon, Wim van Criekinge, Luca Incrocci, Ellen C Zwarthoff, Joost L Boormans
BACKGROUND: Patients with muscle-invasive bladder cancer (MIBC) who receive radiotherapy with curative intent are followed by imaging, cystoscopy, and urine cytology. However, interpretation of cytology and cystoscopy is hampered by the impact of ionizing radiation on cells. OBJECTIVE: To assess the diagnostic performance of a genomic urine assay to detect urinary tract recurrences in patients with MIBC treated by (chemo)radiation. DESIGN SETTING AND PARTICIPANTS: Patients with nonmetastatic MIBC who underwent (chemo)radiation with curative intent from 2016 to 2020 were prospectively included...
April 2024: European urology open science
https://read.qxmd.com/read/38496766/free-fatty-acid-receptors-beyond-fatty-acids-a-computational-journey-to-explore-peptides-as-possible-binders-of-gpr120
#15
JOURNAL ARTICLE
Lorenzo Pedroni, Florinda Perugino, Fabio Magnaghi, Chiara Dall'Asta, Gianni Galaverna, Luca Dellafiora
Free fatty acids receptors, with members among G protein-coupled receptors (GPCRs), are crucial for biological signaling, including the perception of the so called "fatty taste". In recent years, GPR120, a protein belonging to the GPCR family, drew attention as an interesting pharmacological target to cope with obesity, satiety and diabetes. Apart from long chain fatty acids, which are GPR120 natural agonists, other synthetic molecules were identified as agonists expanding the chemical space of GPR120's ligands...
2024: Current research in food science
https://read.qxmd.com/read/38496688/systemic-immune-index-predicts-tumor-infiltrating-lymphocyte-intensity-and-immunotherapy-response-in-small-cell-lung-cancer
#16
JOURNAL ARTICLE
Chaoqiang Deng, Jiatao Liao, Zichen Fu, Fangqiu Fu, Di Li, Yuan Li, Jialei Wang, Haiquan Chen, Yang Zhang
BACKGROUND: Despite recent progresses in immune checkpoint blockade (ICB) in small-cell lung cancer (SCLC), a lack of understanding regarding the systemic tumor immune environment (STIE) and local tumor immune microenvironment (TIME) makes it difficult to accurately predict clinical outcomes and identify potential beneficiaries from ICB therapy. METHODS: We enrolled 191 patients with stage I-III SCLC and comprehensively evaluated the prognostic role of STIE by several quantitative measurements, and further integrate it with a local immune score system (LISS) established by eXtreme Gradient Boosting (XGBoost) machine learning algorithm...
February 29, 2024: Translational Lung Cancer Research
https://read.qxmd.com/read/38496654/myt1l-deficiency-impairs-excitatory-neuron-trajectory-during-cortical-development
#17
Allen Yen, Xuhua Chen, Dominic D Skinner, Fatjon Leti, MariaLynn Crosby, Jessica Hoisington-Lopez, Yizhe Wu, Jiayang Chen, Robi D Mitra, Joseph D Dougherty
Mutations that reduce the function of MYT1L, a neuron-specific transcription factor, are associated with a syndromic neurodevelopmental disorder. Furthermore, MYT1L is routinely used as a proneural factor in fibroblast-to-neuron transdifferentiation. MYT1L has been hypothesized to play a role in the trajectory of neuronal specification and subtype specific maturation, but this hypothesis has not been directly tested, nor is it clear which neuron types are most impacted by MYT1L loss. In this study, we profiled 313,335 nuclei from the forebrains of wild-type and MYT1L-deficient mice at two developmental stages: E14 at the peak of neurogenesis and P21, when neurogenesis is complete, to examine the role of MYT1L levels in the trajectory of neuronal development...
March 7, 2024: bioRxiv
https://read.qxmd.com/read/38496588/sars-cov-2-antibody-prevalence-by-industry-workplace-characteristics-and-workplace-infection-prevention-and-control-measures-north-carolina-2021-to-2022
#18
Carolyn Gigot, Nora Pisanic, Kristoffer Spicer, Meghan F Davis, Kate Kruczynski, Magdielis Gregory Rivera, Kirsten Koehler, D J Hall, Devon J Hall, Christopher D Heaney
BACKGROUND: The COVID-19 pandemic has disproportionately affected workers in certain industries and occupations, and the workplace can be a high risk setting for SARS-CoV-2 transmission. In this study, we measured SARS-CoV-2 antibody prevalence and identified work-related risk factors in a population primarily working at industrial livestock operations. METHODS: We used a multiplex salivary SARS-CoV-2 IgG antibody assay to determine infection-induced antibody prevalence among 236 adult (≥18 years) North Carolina residents between February 2021 and August 2022...
March 8, 2024: medRxiv
https://read.qxmd.com/read/38496586/clinical-performance-of-cas13a-based-point-of-care-lateral-flow-assay-for-detecting-neisseria-gonorrhoeae
#19
Lao-Tzu Allan-Blitz, Gabriela Sanders, Palak Shah, Gordon Adams, Jana Jarolimova, Kevin Ard, John A Branda, Jeffrey D Klausner, Pardis C Sabeti, Jacob E Lemieux
BACKGROUND: Diagnosis of Neisseria (N.) gonorrhoeae is dependent on nucleic acid amplification testing (NAAT), which is not available in resource-limited settings where the prevalence of infection is highest. Recent advances in molecular diagnostics leveraging the high specificity of CRISPR enzymes can permit field-deployable, point-of-care lateral flow assays. We previously reported on the development and in vitro performance of a lateral flow assay for detecting N. gonorrhoeae . Here we aimed to pair that assay with point-of-care DNA extraction techniques and assess the performance on clinical urine specimens...
March 4, 2024: medRxiv
https://read.qxmd.com/read/38496498/nanopore-sequencing-of-1000-genomes-project-samples-to-build-a-comprehensive-catalog-of-human-genetic-variation
#20
Jonas A Gustafson, Sophia B Gibson, Nikhita Damaraju, Miranda Pg Zalusky, Kendra Hoekzema, David Twesigomwe, Lei Yang, Anthony A Snead, Phillip A Richmond, Wouter De Coster, Nathan D Olson, Andrea Guarracino, Qiuhui Li, Angela L Miller, Joy Goffena, Zachery Anderson, Sophie Hr Storz, Sydney A Ward, Maisha Sinha, Claudia Gonzaga-Jauregui, Wayne E Clarke, Anna O Basile, Andre Corvelo, Catherine E Reeves, Adrienne Helland, Rajeeva Lochan Musunuri, Mahler Revsine, Karynne E Patterson, Cate Paschal, Christina Zakarian, Sara Goodwin, Tanner D Jensen, Esther Robb, W Richard McCombie, Fritz J Sedlazeck, Justin M Zook, Stephen B Montgomery, Erik Garrison, Mikhail Kolmogorov, Michael C Schatz, Richard N McLaughlin, Harriet Dashnow, Michael C Zody, Matthew Loose, Miten Jain, Evan E Eichler, Danny E Miller
Less than half of individuals with a suspected Mendelian condition receive a precise molecular diagnosis after comprehensive clinical genetic testing. Improvements in data quality and costs have heightened interest in using long-read sequencing (LRS) to streamline clinical genomic testing, but the absence of control datasets for variant filtering and prioritization has made tertiary analysis of LRS data challenging. To address this, the 1000 Genomes Project ONT Sequencing Consortium aims to generate LRS data from at least 800 of the 1000 Genomes Project samples...
March 7, 2024: medRxiv
keyword
keyword
32322
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.