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Aleksandra Kovaleva, Natalia Irishina, Augusto Pereira, Tatiana Cuesta-Guardiola, Luis Ortiz-Quintana
BACKGROUND: Surgical rescue of methotrexate-treated ectopic pregnancy is necessary when tubal rupture or medical therapy failure is detected during post-therapeutic monitoring. It is known that an increased beta human chorionic gonadotropin (β-hCG) concentration is the most important factor associated with treatment failure. Therefore, we suggested that relative changes in serum β-hCG could predict a successful result of medical treatment, leading to facilitation of the decision to forgo the prospect of possible surgical rescue...
October 27, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Wenpei Fan, Nan Lu, Peng Huang, Yi Liu, Zhen Yang, Sheng Wang, Guocan Yu, Yijing Liu, Junkai Hu, Qianjun He, Junle Qu, Tianfu Wang, Xiaoyuan Chen
Glucose is a key energy supplier and nutrient for tumor growth. Herein, inspired by the glucose oxidase (GOx)-assisted conversion of glucose into gluconic acid and toxic H2 O2 , a novel treatment paradigm of starving-like therapy is developed for significant tumor-killing effects, more effective than conventional starving therapy by only cutting off the energy supply. Furthermore, the generated acidic H2 O2 can oxidize l-Arginine (l-Arg) into NO for enhanced gas therapy. By using hollow mesoporous organosilica nanoparticle (HMON) as a biocompatible/biodegradable nanocarrier for the co-delivery of GOx and l-Arg, a novel glucose-responsive nanomedicine (l-Arg-HMON-GOx) has been for the first time constructed for synergistic cancer starving-like/gas therapy without the need of external excitation, which yields a remarkable H2 O2 -NO cooperative anticancer effect with minimal adverse effect...
December 9, 2016: Angewandte Chemie
Antoine Muller, Chris Clarkson
The notion that the evolution of core reduction strategies involved increasing efficiency in cutting edge production is prevalent in narratives of hominin technological evolution. Yet a number of studies comparing two different knapping technologies have found no significant differences in edge production. Using digital analysis methods we present an investigation of raw material efficiency in eight core technologies broadly representative of the long-term evolution of lithic technology. These are bipolar, multiplatform, discoidal, biface, Levallois, prismatic blade, punch blade and pressure blade production...
2016: PloS One
Hongxia Li, Ying Liao, Yuli Wang, Ping Liu, Chufan Sun, Yonghong Chen, Chaoshu Tang, Hongfang Jin, Junbao Du
OBJECTIVE: The study was designed to examine if baroreflex sensitivity (BRS) could predict the short-term outcome of postural tachycardia syndrome (POTS) in children. METHODS: Seventy-seven children subjects were included in the study. Among them, 45 children were in the POTS group and another 32 healthy children were in the control group. A ninety-day clinical follow-up was conducted and the symptom score before and after the follow-up was calculated for POTS patients by using POTS score system...
2016: PloS One
S V Sapelkin, M R Kuznetsov
With due regard to the requirements of evidence-based medicine, the article contains a review of present-day positions concerning conservative therapy in patients with peripheral artery diseases and chronic arterial ischaemia, represented in the latest Russian and foreign consensus documents, showing importance of bringing the basic provisions of the consensus documents to the notice of practical health-care providers with the aim of working out more effective therapeutic regimens. Some sections of the guidelines regarding the duration of treatment, among the number, require definite specification with the wording of more clear-cut practical conclusions...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
A Yu Bryushkov, P V Ershov, N A Sergeeva, V Yu Bogachev
The study was aimed at evaluating a possibility of correcting endothelial dysfunction by means of angioprotective therapy with natural-origin bioflavonoids in patients presenting with acute venous thromboses. Ours was an open comparative prospective study including a total of thirty 34-to-60-year-old patients suffering from lower limb deep vein thrombosis. The patients were subdivided into two groups. The Study Group was composed of 15 patients receiving on the background of anticoagulant therapy with direct thrombin inhibitors (dabigatran etexilate at a daily dose of 300 mg) natural-origin angioprotectors (red grape leaf extract)...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Sertac Esin, Mutlu Hayran, Yusuf Aytac Tohma, Mahmut Guden, Ismail Alay, Deniz Esinler, Serdar Yalvac, Omer Kandemir
OBJECTIVE: To compare different ultrasonographic fetal weight estimation formulas in predicting the fetal birth weight of preterm premature rupture of membrane (PPROM) fetuses. METHODS: Based on the ultrasonographic measurements, the estimated fetal weight (EFW) was calculated according to the published formulas. The comparisons used estimated birth weight (EBW) and observed birth weight (OBW) to calculate the mean absolute percentage error [(EBW-OBW)/OBW×100], mean percentage error [(EBW-OBW)/OBW×100)] and their 95% confidence intervals...
December 9, 2016: Journal of Perinatal Medicine
Helena Hildenwall, Florida Muro, Jaqueline Jansson, George Mtove, Hugh Reyburn, Ben Amos
OBJECTIVE: To assess the role of point of care assessment of C-reactive protein (CRP) and white blood cell (WBC) count to identify bacterial illness in Tanzanian children with nonsevere nonmalarial fever. METHODS: From the outpatient department of a district hospital in Tanzania 428 patients between 3 months and 5 years of age who presented with fever and a negative malaria test were enrolled. All had a physical examination and bacterial cultures from blood and urine...
December 9, 2016: Tropical Medicine & International Health: TM & IH
Thor Haahr, Anne S Ersbøll, Mona A Karlsen, Jens Svare, Kirstine Sneider, Lene Hee, Louise K Weile, Agnes Ziobrowska-Bech, Claus Østergaard, Jørgen S Jensen, Rikke B Helmig, Niels Uldbjerg
As part of his speeches, the Roman senator Cato the Elder frequently uttered "Carthago delenda est" (Carthage must be destroyed). Similarly, Lamont and colleagues frequently utter that the "wrong patients with the wrong diagnosis were given wrong antibiotics at the wrong gestational age". We respect that Lamont and colleagues find it difficult to accept meta-analyses, which "cut a toe and a bit of a heel" to merge evidence from more publications, and we certainly cannot exclude the possibility that future research will change clinical practice...
December 9, 2016: Acta Obstetricia et Gynecologica Scandinavica
Ayesha Heinis, Jeroen van Dillen, Janine Oosting, Sarah Rhöse, Frank Vandenbussche, Joris Van Drongelen
INTRODUCTION: Point-of-care testing of fetal scalp blood lactate is used as an alternative for pH analysis in fetal scalp blood sampling (FBS) during labor. Lactate measurements are not standardized and values vary with each device used. The aim of this study was to evaluate StatStrip Lactate (SSL) in the clinical setting in comparison to lactate (RLL) and pH (RLpH) by RapidLab. MATERIALS AND METHODS: We obtained 323 FBS samples from 139 women. Parallel sampling of SSL and RLL/RLpH was performed in 247 samples...
December 9, 2016: Acta Obstetricia et Gynecologica Scandinavica
Jianqin Cao, Jinwei Yang, Yuqiu Zhou, Fuliu Chu, Xiwu Zhao, Weiren Wang, Yunlong Wang, Tao Peng
BACKGROUND: Social anxiety disorder (SAD) is one of the most prevalent mental health problems, but there is little research concerning the effective screening instruments in practice. METHODS: This study was designed to examine the discriminative validity of Interaction Anxiousness Scale (IAS) and Brief Social Phobia Scale (BSPS) for the screening of SAD through the compared and combined analysis. Firstly, 421 Chinese undergraduates were screened by the IAS and BSPS...
December 2016: Journal of Mental Health
Keith Cutting
Most stoma flanges are made of hydrocolloid material. Hydrocolloid is a hydrophilic material that attracts water, potentially resulting in moisture becoming trapped between the flange and skin. Also, as hydrocolloids are absorbent, the material breaks down over time, and there is a risk that some of the adhesive can remain on the skin on removal. Unlike hydrocolloids, silicone comprises fully cross-linked silicone polymers whose properties have been engineered to manage moisture without breaking down (i.e. manage the transepidermal water loss (TEWL))...
December 8, 2016: British Journal of Nursing: BJN
Emily L Gill, Richard A Yost, Vinata Vedam-Mai, Timothy J Garrett
Preparation of tissue for matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) generally involves embedding the tissue followed by freezing and cryosectioning, usually between 5-25 μm thick, depending on the tissue type and the analyte(s) of interest. The brain is approximately 60% fat; it therefore lacks rigidity and poses structural preservation challenges during sample preparation. Histological sample preparation procedures are generally transferable to MALDI-MSI; however, there are various limitations...
December 9, 2016: Analytical Chemistry
Rozhan Sheykhani, Michael Berns, Arthur Forer
Separating anaphase chromosomes in crane-fly spermatocytes are connected by elastic tethers, as originally described by [LaFountain et al., 2002]: telomere-containing arm fragments severed from the arms move backwards to the partner telomeres. We have tested whether the tethers coordinate the movements of separating partner chromosomes. In other cell types anaphase chromosomes move faster, temporarily, when their kinetochore microtubules are severed. However, in crane-fly spermatocytes the chromosomes move at their usual speed when their kinetochore microtubules are severed...
December 9, 2016: Cytoskeleton
I Ponce, C Aldunate, L Valenzuela, S Sepúlveda, G Garrido, U Kemmerling, G Cabrera, N Galanti
FLAP endonucleases (FEN) are involved both in DNA replication and repair by processing DNA intermediaries presenting a nucleotide flap using its phosphodiesterase activity. In spite of these important functions in DNA metabolism this enzyme was not yet studied in Trypanosomatids. Trypanosoma cruzi, the ethiological agent of Chagas disease, presents two dividing cellular forms (epimastigote and amastigote) and one non-proliferative, infective form (trypomastigote). The parasite survives DNA damage produced by reactive species generated in its hosts...
December 9, 2016: Journal of Cellular Biochemistry
Amélie Neuville, Louis Renaud, Thi Thuy Luu, Mona Wetrhus Minde, Espen Jettestuen, Jan Ludvig Vinningland, Aksel Hiorth, Dag Kristian Dysthe
In this paper, we propose a simple method to embed transparent reactive materials in a microfluidic cell, and to observe in situ the dissolution of the material. As an example, we show how to obtain the dissolution rate of a calcite window of optical quality, dissolved in water and hydrochloric acid (HCl). These fluids circulate at controlled flowrates in a channel which is obtained by xurography: double sided tape is cut out with a cutter plotter and placed between the calcite window and a non-reactive support...
December 9, 2016: Lab on a Chip
Alladi Mohan, S Aparna Reddy, Alok Sachan, Kvs Sarma, D Prabath Kumar, Mahesh V Panchagnula, Pvln Srinivasa Rao, B Siddhartha Kumar, P Krishnaprasanthi
BACKGROUND & OBJECTIVES: Glycosylated haemoglobin (HbA 1c ) has been in use for more than a decade, as a diagnostic test for type 2 diabetes. Validity of HbA 1c needs to be established in the ethnic population in which it is intended to be used. The objective of this study was to derive and validate a HbA 1c cut-off value for the diagnosis of type 2 diabetes in the ethnic population of Rayalaseema area of south India. METHODS: In this cross-sectional study, consecutive patients suspected to have type 2 diabetes underwent fasting plasma glucose (FPG) and 2 h post-load plasma glucose (2 h-PG) measurements after a 75 g glucose load and HbA 1c estimation...
August 2016: Indian Journal of Medical Research
Pamela J Hines
No abstract text is available yet for this article.
December 2, 2016: Science
S K Srivastava, S Shinde, S K Singh, S Mehrotra, M R Verma, A K Singh, S Nandi, N Srivastava, S K Singh, T K Goswami, S K Bhure, H Kumar, S K Ghosh
Antisperm antibodies have been found in repeat-breeding(RB) cows, and those causing agglutination and/or immobilization of sperm are considered to be closely related to unexplained infertility. However, a standard protocol for identifying antisperm antibodies (ASA) in cattle is not validated. Therefore, an investigation was undertaken to evaluate sperm immobilization (SIT), sperm agglutination (SAT) and immunoperoxidase (IPT)assays for detection of ASA in serum and their respective threshold levels for confirmation...
December 8, 2016: Reproduction in Domestic Animals, Zuchthygiene
Sameer Ahmed, Kyle K VanKoevering, Stephanie Kline, Glenn E Green, H Alexander Arts
OBJECTIVES/HYPOTHESIS: To explore the perioperative utility of three-dimensionally (3D)-printed temporal bone models of patients undergoing repair of lateral skull base defects and spontaneous cerebrospinal fluid leaks with the middle cranial fossa approach. STUDY DESIGN: Case series. METHODS: 3D-printed temporal bone models-based on patient-specific, high-resolution computed tomographic imaging-were constructed using inexpensive polymer materials...
December 9, 2016: Laryngoscope
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