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https://www.readbyqxmd.com/read/28735646/hyperhomocysteinemia-and-age-related-macular-degeneration-role-of-inflammatory-mediators-and-pyroptosis-a-proposal
#1
Mahavir Singh, Suresh C Tyagi
Age-related macular degeneration (AMD) and pyroptosis cause irreversible vascular changes in the eyes leading to central vision loss in patients. It is the most common eye disease affecting millions of people aged 50years or older, and is slowly becoming a major health problem worldwide. The disease mainly affects macula lutea, an oval-shaped pigmented area surrounding fovea near the center of retina, a region responsible for visual acuity. It is fairly a complex disease as genetics of patients, environmental triggers as well as risk factors such as age, family history of CVDs, diabetes, gender, obesity, race, hyperopia, iris color, smoking, diabetes, exposure to sun light and pyroptosis have all been clubbed together as probable causes of macular degeneration...
August 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28731878/correlation-of-corneal-biomechanical-stiffness-with-refractive-error-and-ocular-biometry-in-a-pediatric-population
#2
Jyoti Matalia, Mathew Francis, Pooja Gogri, Pratibha Panmand, Himanshu Matalia, Abhijit Sinha Roy
PURPOSE: To assess the correlation between corneal biomechanical stiffness and refractive error (RE) in the pediatric population. METHODS: A total of 733 pediatric eyes were included in the study retrospectively. All eyes underwent corneal tomography (Pentacam), RE assessment, and air-puff deformation (Corvis-ST). Waveform analyses of deformation provided corneal stiffness (CS) and extraocular tissue stiffness (EOS). Eyes were subgrouped into emmetropia [manifest refraction spherical equivalent (MRSE) ∼ 0 D], hyperopia (MRSE > 0 D), myopia I (MRSE between 0 D and -3 D), myopia II (MRSE between -3 D and -6 D), and myopia III (MRSE greater than -6 D) for multivariate analyses...
July 19, 2017: Cornea
https://www.readbyqxmd.com/read/28728185/novel-presenting-phenotype-in-a-child-with-autosomal-dominant-best-s-vitelliform-macular-dystrophy
#3
Yasmine F Abdalla, Gabriella De Salvo, Ahmad Elsahn, James E Self
Best's macular dystrophy (BMD) usually manifests with visual failure in the first or second decade of life; however, there is a large variability in expressivity of the disease, and some patients have no manifestation other than a pathological electro-oculogram (EOG). Autosomal dominant Best's vitelliform macular dystrophy (AD-BVMD) has a very specific phenotype that varies with the stage of the disease. In recent years, the authors have seen description of another clinical entity known as autosomal recessive BMD...
July 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28721935/prevalence-of-eye-disease-and-visual-impairment-in-%C3%A3-le-de-la-gonave-ha%C3%A3-ti
#4
B Tousignant, J Brûlé
Epidemiological data describing the prevalence of blindness and visual impairment in Haiti are sparse. The Haitian National Committee for the Prevention of Blindness (CNPC) estimates the prevalence of blindness at 1 %. Other regional data estimate moderate and severe visual impairment at 5% and 22%, respectively. IRIS Mundial (IM) is a non-governmental organization collaborating with the CNPC to develop eye care infrastructure in Haiti. To estimate the prevalence and causes of blindness and visual impairment on the Haitian island of Gonâve, to assist in planning of relevant eye care infrastructure...
July 19, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28716601/changes-in-refractive-status-in-an-elderly-chinese-population-in-a-7-year-follow-up-the-shihpai-eye-study
#5
Tung-Mei Kuang, Su-Ying Tsai, Catherine Jiu-Ling Liu, Yu-Chieh Ko, Shui-Mei Lee, Pesus Chou
BACKGROUND: Refractive error is the major cause of moderate and severe visual impairment. Visual impairment limits people's ability to perform daily tasks and affects their quality of life. Longitudinal data on the refractive status of the elderly was available only for whites and Africans. The purpose of this study was to report the 7-year incidence of myopia, hyperopia and refractive error change as well as their associated risk factors in a metropolitan elderly Chinese population. METHODS: The Shihpai Eye Study 2006 included 460/824 (55...
July 14, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28712891/corneo-scleral-contact-lenses-in-an-uncommon-case-of-keratoconus-with-high-hyperopia-and-astigmatism
#6
Esteban Porcar, Juan Carlos Montalt, Enrique España-Gregori, Cristina Peris-Martínez
PURPOSE: To analyse the visual quality achieved by fitting corneo-scleral contact lenses (CScL) in an uncommon case of bilateral keratoconus, high hyperopia and astigmatism. METHODS: A 45-year-old man presented for eye examination due to the unsatisfactory quality of his vision wearing soft toric contact lenses. He presented high hyperopia and astigmatism with bilateral keratoconus. He was fitted with CScL to correct his irregular astigmatism and ocular aberrations...
July 13, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28702951/the-prevalence-of-refractive-errors-among-adult-rural-populations-in-iran
#7
Hassan Hashemi, Payam Nabovati, Abbasali Yekta, Fereshteh Shokrollahzadeh, Mehdi Khabazkhoob
PURPOSE: The aim was to determine the prevalence of myopia and hyperopia and related factors in underserved rural areas in Iran. METHODS: Under random cluster sampling, two rural regions were randomly selected in the north and southwest of the country, and 3,061 persons over 15 years of age were invited into the study. After selecting samples, all participants had refraction, measurement of uncorrected vision and visual acuity and ocular health examination by slitlamp biomicroscopy...
July 12, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28687691/vascularisation-of-the-anterior-lens-capsule-in-an-eye-with-excellent-visual-acuity
#8
Andrew Walkden, Shi Zhuan Tan, Leon Au, Karl Mercieca
A 53-year-old phakic female with a history of nanophthalmos and hyperopia was incidentally found to have unilateral neovascularisation on the left inferoanterior lens surface on routine review for ocular hypertension.
July 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28670145/anisohypermetropia-as-a-sign-of-unilateral-glaucoma-in-the-pediatric-population
#9
Deborah Kl Tan, Gillian H Teh, Ching Lin Ho, Boon Long Quah
Childhood glaucoma poses a diagnostic and therapeutic challenge to ophthalmologists. Difficulty in examination and limitations on ability to perform structural and functional testing of optic nerve make diagnosis and verification of glaucoma control difficult in children. It is well known that an excessive loss of hyperopia is a useful sign in alerting the examining ophthalmologist to the possible diagnosis of glaucoma. We present an interesting case of juvenile onset glaucoma presenting with anisohypermetropic amblyopia in one eye and normal vision in the fellow eye that has glaucoma...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28663837/hyperopic-q-optimized-algorithms-a-theoretical-study-on-factors-influencing-optical-quality
#10
Jose R Jiménez, Aixa Alarcón, Rosario G Anera, L Jiménez Del Barco
In this work, we analyze the way in which pupil size, optical zone, and initial hyperopic level influence optical quality for hyperopic Q-optimized corneal refractive surgery. Different Q-optimized algorithms and the Munnerlyn formula were tested to analyze the optical quality of the final retinal image for initial hyperopic errors from 1D to 5D. Three optical zones (5.5, 6, and 6.5 mm) and two pupil diameters (5 and 7 mm) were considered. To evaluate optical quality, we computed the modulation transfer function (MTF) and the area under MTF (MTFa)...
March 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28657533/-the-ametrop%C3%A3-as-updated-review-for-non-ophthalmologists-physicians
#11
REVIEW
Virgilio Galvis, Alejandro Tello, Oscar Blanco, Andrea N Laiton, Marion R Dueñas, Priscila Alejandra Hidalgo
Refractive errors are caused by a decoupling of the power of convergence of the eye lens, the cornea and lens, which make the rays reaching the eye to focus and generate an image, and the retina, which is the biological photosensitive screen where the image will be transformed into a nerve impulse. These defects include myopia, hyperopia and astigmatism. Presbyopia can also be considered a refractive defect, but of special features, since only affects near vision in patients older than 40 years. By altering the quality of the focused image on the most sensitive area of the retina (the macula), they decrease visual acuity...
2017: Revista de la Facultad de Ciencias Médicas
https://www.readbyqxmd.com/read/28634928/comparison-of-formulas-and-methods-for-high-myopia-patients-requiring-intraocular-lens-powers-less-than-six-diopters
#12
Harry S Geggel
PURPOSE: To determine the best method to minimize postoperative hyperopia and achieve mild myopia in patients requiring low-powered (<6.00 D) MN60MA intraocular lenses (IOLs). METHODS: This retrospective non-comparative case series consists of 32 eyes (20 patients). Postoperative spherical equivalent (SE) refractions were compared using four methods: standard formulas with varying target refractions (Haigis -1.00 D, Hoffer Q -1.75 D, Holladay 1 -1.50 D and SRK/T -1...
June 20, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28596085/brief-hyperopic-defocus-or-form-deprivation-have-varying-effects-on-eye-growth-and-ocular-rhythms-depending-on-the-time-of-day-of-exposure
#13
Debora L Nickla, Kelsey Jordan, Jane Yang, Kristen Totonelly
It is generally accepted that myopic defocus is a more potent signal to the emmetropization system than hyperopic defocus: one hour per day of myopic defocus cancels out 11 h of hyperopic defocus. However, we have recently shown that the potency of brief episodes of myopic defocus at inhibiting eye growth depends on the time of day of exposure. We here ask if this will also be true of the responses to brief periods of hyperopic defocus: may integration of the signal depend on time of day? If so, are the rhythms in axial length and choroidal thickness altered? Hyperopic defocus: Birds had one eye exposed to hyperopic defocus by the wearing of -10D lenses for 2 or 6 h at one of 3 times of day for 5 days: Morning (7 am - 9 am: n = 13; 7 am - 1 pm: n = 6), Mid-day (12 pm - 2 pm: n = 20; 10 am - 4 pm: n = 8), or Evening (7 pm - 9 pm: n = 12; 2 pm - 8 pm: n = 11)...
June 5, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28586496/small-incision-lenticule-extraction-smile-for-hyperopia-optical-zone-diameter-and-spherical-aberration-induction
#14
Dan Z Reinstein, Kishore R Pradhan, Glenn I Carp, Timothy J Archer, Marine Gobbe, Walter Sekundo, Raynan Khan, Purushottam Dhungana
PURPOSE: To evaluate optical zone diameter efficacy and spherical aberration change in hyperopic small incision lenticule extraction (SMILE). METHODS: Prospective study of 60 consecutive hyperopic SMILE procedures using the VisuMax femtosecond laser (Carl Zeiss Meditec, Jena, Germany) and matched LASIK procedures with the VisuMax and MEL 80 excimer (Carl Zeiss Meditec) lasers. Inclusion criteria were maximum attempted hyperopic meridian of between +1.00 and +7.00 diopters (D)...
June 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28579751/treatment-of-moderate-to-high-hyperopia-with-the-wavelight-allegretto-400-and-ex500-excimer-laser-systems
#15
Manoj Motwani, Ronald Pei
PURPOSE: To evaluate the efficacy of treating patients with +3.00 diopters (D) to +6.00 D of hyperopia via laser-assisted in situ keratomileusis (LASIK) with the WaveLight Allegretto 400 and EX500 excimer laser systems. SETTING: Private clinical ophthalmology practice. PATIENTS AND METHODS: This was a retrospective study of patients undergoing LASIK treatments of +3.00 to +6.00 D on two different WaveLight laser systems: 163 eyes on the 400 (Hertz) Hz system and 54 eyes on the 500 Hz system...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28579750/refractive-predictability-in-eyes-with-intraocular-gas-tamponade-results-of-a-prospective-controlled-clinical-trial
#16
Lars Wagenfeld, Kristin Hermsdorf, Birthe Stemplewitz, Vasyl Druchkiv, Andreas Frings
PURPOSE: To determine the postoperative refractive error in eyes with intraocular gas tamponade in combined phacovitrectomy using a Z-haptic intraocular lens (IOL). METHODS: This prospective non-randomized case-control study compared patients with combined phacovitrectomy with or without intraocular gas tamponade to cataract surgery-only. The main outcome measure was the IOL power prediction error (PE). Secondary outcome measures were spherical equivalent, anterior chamber depth (ACD), and axial length...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28577860/glaucoma
#17
REVIEW
Jost B Jonas, Tin Aung, Rupert R Bourne, Alain M Bron, Robert Ritch, Songhomitra Panda-Jonas
Glaucoma is a heterogeneous group of diseases characterised by cupping of the optic nerve head and visual-field damage. It is the most frequent cause of irreversible blindness worldwide. Progression usually stops if the intraocular pressure is lowered by 30-50% from baseline. Its worldwide age-standardised prevalence in the population aged 40 years or older is about 3·5%. Chronic forms of glaucoma are painless and symptomatic visual-field defects occur late. Early detection by ophthalmological examination is mandatory...
May 31, 2017: Lancet
https://www.readbyqxmd.com/read/28546940/refractive-errors-among-children-adolescents-and-adults-attending-eye-clinics-in-mexico
#18
Francisco Gomez-Salazar, Abraham Campos-Romero, Humberto Gomez-Campaña, Cinthia Cruz-Zamudio, Mariano Chaidez-Felix, Nidia Leon-Sicairos, Jorge Velazquez-Roman, Hector Flores-Villaseñor, Secundino Muro-Amador, Alma Marlene Guadron-Llanos, Javier J Martinez-Garcia, Joel Murillo-Llanes, Jaime Sanchez-Cuen, Alejando Llausas-Vargas, Gerardo Alapizco-Castro, Ana Irineo-Cabrales, Enrique Graue-Hernandez, Tito Ramirez-Luquin, Adrian Canizalez-Roman
AIM: To assess the proportion of refractive errors in the Mexican population that visited primary care optometry clinics in fourteen states of Mexico. METHODS: Refractive data from 676 856 patients aged 6 to 90y were collected from optometry clinics in fourteen states of Mexico between 2014 and 2015. The refractive errors were classified by the spherical equivalent (SE), as follows: sphere+½ cylinder. Myopia (SE>-0.50 D), hyperopia (SE>+0.50 D), emmetropia (-0...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546692/age-related-changes-in-the-foveal-bulge-in-healthy-eyes
#19
Kumar Saurabh, Rupak Roy, Preeti Sharma, Dhileesh P Chandrasekharan, Kaustubh Deshmukh, Chinmayi Vyas
BACKGROUND: Intact foveal bulge has been associated with good visual outcome in retinal diseases. The aim of this study was to study the variation in foveal bulge with age. METHODS: It was an observational cross-sectional study conducted between October 2014 and December 2015. Totally, 101 eyes of 101 healthy volunteers were studied in a tertiary care center. All individuals had best corrected visual acuity of 20/20 or better. High myopia (>6 D), high hyperopia (>4 D), unstable fixation, media opacities and retinal disorder like diabetic retinopathy, retinal vein occlusion were the exclusion criteria...
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28542088/corneal-breakthrough-haze-after-photorefractive-keratectomy-with-mitomycin-c-incidence-and-risk-factors
#20
Igor Kaiserman, Naʼava Sadi, Michael Mimouni, Tzahi Sela, Gur Munzer, Shmuel Levartovsky
PURPOSE: To identify preoperative and intraoperative factors affecting breakthrough corneal haze incidence after photorefractive keratectomy (PRK) with mitomycin C (MMC). METHODS: In this retrospective study of PRK performed at the Care Vision Refractive Laser Center, Tel Aviv, Israel, a total of 7535 eyes (n = 3854 patients; mean age ± SD, 26 ± 6 years; 55% men) underwent PRK with intraoperative MMC application. Patients with histories of corneal pathology or surgery were excluded...
May 23, 2017: Cornea
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