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https://www.readbyqxmd.com/read/29342105/neuroimmune-driven-neuropathic-pain-establishment-a-focus-on-gender-differences
#1
REVIEW
Vincenzo Coraggio, Francesca Guida, Serena Boccella, Mariantonietta Scafuro, Salvatore Paino, Domenico Romano, Sabatino Maione, Livio Luongo
The role of neuroinflammatory cells in the establishment of neuropathic pain has been investigated in depth in the last few years. In particular, microglia have been shown to be key players in the induction of tactile allodynia, as they release proinflammatory molecules that, in turn, sensitize nociceptive neurons within the spinal cord. However, the role of peripheral immune cells such as macrophages, infiltrating monocytes, mast cells, and T-cells has been highlighted in the last few studies, even though the data are still conflicting and need to be clarified...
January 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29341334/incidence-and-prognostic-impact-of-cytogenetic-aberrations-in-patients-with-systemic-mastocytosis
#2
Nicole Naumann, Mohamad Jawhar, Juliana Schwaab, Sebastian Kluger, Johannes Lübke, Georgia Metzgeroth, Henning D Popp, Nada Khaled, Hans-Peter Horny, Karl Sotlar, Peter Valent, Claudia Haferlach, Gudrun Göhring, Brigitte Schlegelberger, Manja Meggendorfer, Wolf-Karsten Hofmann, Nicholas C P Cross, Andreas Reiter, Alice Fabarius
The clinical behavior of systemic mastocytosis (SM) is strongly associated with activating mutations in KIT (D816V in >80% of cases), with the severity of the phenotype influenced by additional somatic mutations, e.g. in SRSF2, ASXL1 or RUNX1. Complex molecular profiles are frequently associated with the presence of an associated hematologic neoplasm (AHN) and an unfavorable clinical outcome. However, little is known about the incidence and prognostic impact of cytogenetic aberrations. We analyzed cytogenetic and molecular characteristics of 109 patients (KIT D816V+, n=102, 94%) with indolent (ISM, n=26) and advanced SM (n=83) with (n=73, 88%) or without AHN...
January 17, 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29339006/food-allergy-induces-alteration-in-brain-inflammatory-status-and-cognitive-impairments
#3
Liqing Zhou, Long Chen, Xiaohuan Li, Tingyu Li, Zhifang Dong, Yu Tian Wang
Accumulating evidence supports an increase in emotional and behavioral problems in patients with food allergy, but the underlying mechanism remains poorly understood. Here we found that in addition to inducing an increase of allergic factors in serum, food allergy also increased levels of antigen-specific immunoglobulins and mast cell marker in the brain. In particular, food allergy increased the number of total microglia and the percentage of active microglia in the cerebral cortex and hippocampal CA1 areas, and induced the increase of TNF-α in the cerebral cortex...
January 12, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29338615/assessment-of-canine-mast-cell-tumor-mortality-risk-based-on-clinical-histologic-immunohistochemical-and-molecular-features
#4
Rodrigo S Horta, Gleidice E Lavalle, Lidianne N Monteiro, Mayara C C Souza, Geovanni D Cassali, Roberto B Araújo
Mast cell tumor (MCT) is a frequent cutaneous neoplasm in dogs that is heterogeneous in clinical presentation and biological behavior, with a variable potential for recurrence and metastasis. Accurate prediction of clinical outcomes has been challenging. The study objective was to develop a system for classification of canine MCT according to the mortality risk based on individual assessment of clinical, histologic, immunohistochemical, and molecular features. The study included 149 dogs with a histologic diagnosis of cutaneous or subcutaneous MCT...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29338159/ovariectomy-modifies-th2-and-th17-balance-in-balb-c-allergic-mice
#5
Marcos Paulo Almeida Souza, Fernanda Macedo da Silva Lima, Igor Pereira Muniz, Ítalo Sousa Pereira, Larissa Rodrigues de Oliveira Sousa, Maria Poliana Leite Galantini, Denisar Palmito Dos Santos, Tiana Baqueiro Figueiredo, Robson Amaro Augusto da Silva
Asthma is a chronic inflammation of the airways affecting over 300 million people worldwide. As in the autoimmune diseases, it is well described that women are the most affected by asthma. The higher number of women presenting this pathology suggests the involvement of female sex hormones in the construction of the allergic immune response. Female Balb / c mice were used for the experiments. Thirty-eight animals were separated into four groups: OVX-Ova; Sham-Ova; OVX-Sal; Sham-Sal. Then animals underwent acute allergic induction protocol by Ovalbulmin (OVA)...
December 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29337270/the-cationic-tetradecapeptide-mastoparan-as-a-privileged-structure-for-drug-discovery-enhanced-antimicrobial-properties-of-mitoparan-analogues-modified-at-position-14
#6
John Howl, Lewis Howl, Sarah Jones
Mastoparan (MP) peptides, distributed in insect venoms, induce a local inflammatory response post envenomation. Most endogenous MPs share common structural elements within a tetradecapeptide sequence that adopts an amphipathic helix whilst traversing biological membranes and when bound to an intracellular protein target. Rational modifications to increase cationic charge density and amphipathic helicity engineered mitoparan (MitP), a mitochondriotoxic bioportide and potent secretagogue. Following intracellular translocation, MitP is accreted by mitochondria thus indicating additional utility as an antimicrobial agent...
January 11, 2018: Peptides
https://www.readbyqxmd.com/read/29336501/uncontrolled-asthmatics-have-increased-fceri-and-tgf-%C3%AE-positive-mctc-mast-cells-and-collagen-vi-in-the-alveolar-parenchyma
#7
Cecilia K Andersson, Maria Weitoft, Kristina Rydell-Törmänen, Leif Bjermer, Gunilla Westergren-Thorsson, Jonas S Erjefält
BACKGROUND: Asthma has been associated with increased collagen deposition in both conducting airways and alveolar parenchyma. Mast cells (MCs) are key effector cells in asthma, and have the ability to affect collagen synthesis. However, the link between clinical control and changes in bronchial and alveolar MC phenotypes and specific collagens in controlled and uncontrolled asthma remains unknown. OBJECTIVE: To investigate MC phenotypes in correlation to deposition of specific collagen subtypes in patients with controlled and uncontrolled asthma as well as to healthy controls...
January 16, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29336284/assessing-the-onset-of-allergic-rhinitis-by-nasal-cytology-and-immunoglobulin-e-antibody-levels-in-children
#8
Hirokuni Otsuka, Kuninori Otsuka, Shoji Matsune, Kimihiro Okubo
BACKGROUND: It is difficult to identify the onset of allergic rhinitis in infants because making a conclusive diagnosis can be challenging. OBJECTIVE: We used a combination of cell differentials in nasal swabs and immunoglobulin E (sIgE) antibody values to food and inhalant allergens to make the diagnosis and identify relevant allergens for investigation of the onset of allergic rhinitis. METHODS: We studied 302 children, 2 to 120 months old, who visited our clinic for rhinorrhea...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29336282/role-of-group-2-innate-lymphocytes-in-aspirin-exacerbated-respiratory-disease-pathogenesis
#9
Andrew A White, Taylor A Doherty
Aspirin-exacerbated respiratory disease (AERD) is characterized by chronic eosinophilic nasal polyps, asthma, and airway reactions upon cyclooxygenase (COX) 1 inhibition. AERD is present in up to 7% of adult patients with asthma and the underlying pathogenesis remains largely elusive but prostaglandin D2, cysteinyl leukotrienes, mast cells, and type 2 cytokines are thought to contribute. A wealth of studies have recently implicated group 2 innate lymphoid cells (ILC2), a novel lineage-negative lymphocyte population that produces type 2 cytokines, in human allergic disease pathogenesis...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29336054/the-eaaci-ga%C3%A2-len-edf-wao-guideline-for-the-definition-classification-diagnosis-and-management-of-urticaria-the-2017-revision-and-update
#10
T Zuberbier, W Aberer, R Asero, A H Abdul Latiff, D Baker, B Ballmer-Weber, J A Bernstein, C Bindslev-Jensen, Z Brzoza, R Buense Bedrikow, G W Canonica, M K Church, T Craig, I V Danilycheva, C Dressler, L F Ensina, A Giménez-Arnau, K Godse, M Gonçalo, C Grattan, J Hebert, M Hide, A Kaplan, A Kapp, C H Katelaris, E Kocatürk, K Kulthanan, D Larenas-Linnemann, T A Leslie, M Magerl, P Mathelier-Fusade, R Y Meshkova, M Metz, A Nast, E Nettis, H Oude-Elberink, S Rosumeck, S S Saini, M Sánchez-Borges, P Schmid-Grendelmeier, P Staubach, G Sussman, E Toubi, G A Vena, C Vestergaard, B Wedi, R N Werner, Z Zhao, M Maurer
This evidence and consensus-based guideline was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. The conference was held on December 1st, 2016. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the EU-founded network of excellence, the Global Allergy and Asthma European Network (GA²LEN), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO) with the participation of 48 delegates of 42 national and international societies...
January 15, 2018: Allergy
https://www.readbyqxmd.com/read/29334696/mast-cells-participate-in-chronic-low-grade-inflammation-within-adipose-tissue
#11
REVIEW
P Żelechowska, J Agier, E Kozłowska, E Brzezińska-Błaszczyk
Obesity is reckoned as one of the civilization diseases, posing a considerable global health issue. Evidence points towards a contribution of multitude immune cell populations in obesity pathomechanism and the development of chronic low-grade inflammation in the expanded adipose tissue. Notably, adipose tissue is a reservoir of mast cells which number in individuals with obesity particularly increased. Some of them tend to degranulation what generate secretion of strong pro-inflammatory and regulatory mediators, as well as cytokines/chemokines...
January 15, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29331682/post-mortem-tryptase-cut-off-level-for-anaphylactic-death
#12
R Tse, C X Wong, K Kesha, J Garland, Y Tran, S Anne, H Elstub, A D Cala, C Palmiere, K L Patchett
Serum mast cell tryptase is used to support the diagnosis of anaphylaxis. The recommended clinical cut-off for total tryptase (<11.4μg/L) appears unsuitable in the post mortem setting due to largely unknown processes which result in significantly elevated levels in these samples. Consequently there is no widely accepted tryptase cut-off level for diagnosing an anaphylactic death. This 5-year retrospective study compared total tryptase levels in post mortem femoral blood in anaphylactic deaths and control...
December 28, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29329223/mast-cells-key-contributors-to-cardiac-fibrosis
#13
REVIEW
Scott P Levick, Alexander Widiapradja
Historically, increased numbers of mast cells have been associated with fibrosis in numerous cardiac pathologies, implicating mast cells in the development of cardiac fibrosis. Subsequently, several approaches have been utilised to demonstrate a causal role for mast cells in animal models of cardiac fibrosis including mast cell stabilising compounds, rodents deficient in mast cells, and inhibition of the actions of mast cell-specific proteases such as chymase and tryptase. Whilst most evidence supports a pro-fibrotic role for mast cells, there is evidence that in some settings these cells can oppose fibrosis...
January 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29329020/a-novel-mouse-model-of-atopic-dermatitis-that-is-t-helper-2-th2-polarized-by-an-epicutaneous-allergen
#14
Hyun Jung Park, Wahn Soo Choi, Won Young Lee, Youngsok Choi, Chankyu Park, Jin Hoi Kim, Kwon Ho Hong, Hyuk Song
The pathogenesis of atopic dermatitis (AD) involves T helper 2 (Th2) cells, and effective therapies remain elusive due to the paucity of animal models. We aimed to develop a mouse model of an immune system aberration caused by allergen. Experiments were conducted in two phases. In experiment 1, BALB/c mice were sensitized with one of four chemical allergens - toluene diisocyanate (TDI), hexamethylene diisocyanate (HDI), trimellitic anhydride (TMA), or 2,4-dinitrochlorobenzene (DNCB) - for 3 weeks. Based on results of experiment 1, immunological features were compared between TMA-sensitized BALB/c mice and NC/Nga mice, after exposure to mite extracts, harmful chemicals and detergents in experiment 2...
December 29, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29328028/-skin-pathology-in-diabetes-mellitus-clinical-and-pathophysiological-correlations-review
#15
K Kochet, I Lytus, I Svistunov, O Sulaieva
Skin pathology is registered in vast majority of patients with diabetes mellitus (DM). Despite the abundance of publications on dermatological problems in DM, there is still a number of gaps to be discussed in terms of pathophysiological mechanisms. The goal of this review was to assess the mechanisms of development of different skin pathologies under DM. One of the key pathogenic mechanisms of skin lesions in diabetes is hyperglycemia and the effects of the advanced glycation end products, inducing oxidative stress, endothelial dysfunction and inflammation; that in its turn can accelerate the mechanisms of skin aging, the development of diabetic dermopathy and scleredema diabeticorum...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29326369/successful-treatment-of-postural-orthostatic-tachycardia-and-mast-cell-activation-syndromes-using-naltrexone-immunoglobulin-and-antibiotic-treatment
#16
Leonard B Weinstock, Jill B Brook, Trisha L Myers, Brent Goodman
A patient with severe postural orthostatic tachycardia syndrome (POTS) and mast cell activation syndrome (MCAS) received immunotherapy with low-dose naltrexone (LDN) and intravenous immunoglobulin (IVIg) and antibiotic therapy for small intestinal bacterial overgrowth (SIBO). A dramatic and sustained response was documented. The utility of IVIg in autoimmune neuromuscular diseases has been published, but clinical experience with POTS is relatively unknown and has not been reported in MCAS. As a short-acting mu-opioid antagonist, LDN paradoxically increases endorphins which then bind to regulatory T cells which regulate T-lymphocyte and B-lymphocyte production and this reduces cytokine and antibody production...
January 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29322606/association-of-tumour-infiltrating-regulatory-t-cells-with-adverse-outcomes-in-dogs-with-malignant-tumours
#17
K Sakai, S Maeda, Y Yamada, J K Chambers, K Uchida, H Nakayama, T Yonezawa, N Matsuki
Regulatory T cells (Tregs) infiltrate into a variety of tumour tissues and associate with poor prognosis in humans. However, data on association of Treg infiltration with prognosis is limited in canine tumours. The purpose of this study was to examine the number of tumour-infiltrating Tregs and its association with overall survival (OS) in dogs with malignant tumours. The following 168 canine tumours were included: 37 oral malignant melanomas (OMMs); 14 oral squamous cell carcinomas (OSCCs); 16 pulmonary adenocarcinomas (PAs); 37 mammary carcinomas (MCs); 36 mast cell tumours (MCTs) and 28 hepatocellular carcinomas (HCCs)...
January 11, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29321987/gelam-honey-attenuates-ovalbumin-induced-airway-inflammation-in-a-mice-model-of-allergic-asthma
#18
Nur Salme Suhana Shamshuddin, Rozaini Mohd Zohdi
Allergic asthma is a chronic inflammatory disorder of the pulmonary airways. Gelam honey has been proven to possess anti-inflammatory property with great potential to treat an inflammatory condition. However, the effect of ingestion of Gelam honey on allergic asthma has never been studied. This study aimed to investigate the efficacy of Gelam honey on the histopathological changes in the lungs of a mice model of allergic asthma. Forty-two Balb/c mice were divided into seven groups: control, I, II, III, IV, V and VI group...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29320402/the-secretory-response-of-rat-peritoneal-mast-cells-on-exposure-to-mineral-fibers
#19
Violetta Borelli, Elisa Trevisan, Vita Francesca, Giuliano Zabucchi
BACKGROUND: Exposure to mineral fibers is of substantial relevance to human health. A key event in exposure is the interaction with inflammatory cells and the subsequent generation of pro-inflammatory factors. Mast cells (MCs) have been shown to interact with titanium oxide (TiO₂) and asbestos fibers. In this study, we compared the response of rat peritoneal MCs challenged with the asbestos crocidolite and nanowires of TiO₂ to that induced by wollastonite employed as a control fiber...
January 10, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29319896/skin-inflammation-exacerbates-food-allergy-symptoms-in-epicutaneously-sensitized-mice
#20
Akiko Kawasaki, Naohiro Ito, Hiroki Murai, Motoko Yasutomi, Hironobu Naiki, Yusei Ohshima
BACKGROUND: Cutaneous exposure to food antigen through impaired skin barrier has been shown to induce epicutaneous sensitization, thereby causing IgE-mediated food allergies. OBJECTIVE: We examined whether skin barrier impairment following epicutaneous sensitization exacerbates food allergies. METHODS: BALB/c mice were epicutaneously sensitized by repeated application of ovalbumin (OVA) to MC903-pretreated ear skin for 48 hours weekly and then intragastrically challenged with OVA...
January 10, 2018: Allergy
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