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Saturnino Luján, Ramón Rogel, Enrique Broseta, Francisco Boronat
INTRODUCTION: Penile prosthesis (PP) is the established treatment for patients with erectile dysfunction (ED) who do not respond to phosphodiesterase inhibitors and intracavernosal injections. In general, these devices have been largely successful but there are not free of serious complication such as PP infection (PPI). PPI requires immediate surgical removal or salvage rescue of the PP. AIM: In this report, we present two clinical cases with inflatable PP (IPP) treated locally with antibiotic and high pressure irrigation and then avoid the PP removal or salvage rescue...
December 2016: Sexual Medicine
Lidia Santarpia, Antonio Buonomo, Maria Carmen Pagano, Lucia Alfonsi, Maria Foggia, Michele Mottola, Geremia Zito Marinosci, Franco Contaldo, Fabrizio Pasanisi
BACKGROUND: The prevalence of central venous catheter (CVC)-related blood-stream infections (CRBSI), infecting agents and the effectiveness of antibiotic therapy were evaluated in 172 adult patients on Home Parenteral Nutrition (HPN) at the Clinical Nutrition Outpatient Unit of Federico II University Hospital in Naples, Italy. MATERIALS AND METHODS: The study population consisted of 127 oncological (74%) and 45 (26%) non-oncological patients, for a total of 53,818 (median 104; range 14-1080) CVC days...
December 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Fábio Prestes de Campos, Henry Mor Pansard, Luiz Cláudio Arantes, Arnaldo Teixeira Rodrigues, Melissa Falster Daubermann, Marcos Felipe Azambuja, Laércio Cassol Argenta, Luiz Alberto Michet da Silva
Chagas' disease carries high morbidity and mortality due to acute parasitemia or cardiac, digestive, cutaneous or neurologic chronic lesions. Latin American countries have the majority of infected or at risk people. Transplanted patients using immunosuppressive agents may develop severe and even fatal forms of the disease. The available treatment causes frequent severe side-effects. A 59 years-old woman with end stage renal disease and positive serology for Chagas` disease, but without any clinical manifestation of this pathology, underwent kidney transplantation from a cadaveric donor and displayed three months later a thigh panniculitis from which a biopsy unveiled amastigote forms of Trypanosoma cruzi...
March 2016: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Laura Cuzzolin, Rocco Agostino
PURPOSE: The use of medicines among newborns admitted to intensive care units is characterized by a high prevalence of off-label/unlicensed use and a wide variability in the absence of international guidelines. A prospective cross-sectional study was organized with the aim to analyse drug prescriptions among all 107 Italian level III neonatal intensive care units. METHODS: An online questionnaire was used to collect detailed information for each newborn, and a classification was made about the license status of all prescriptions...
January 2016: European Journal of Clinical Pharmacology
I N D'yakonova, O V Kamkina, Yu S Ishanova, I V Rakhmanova, D S Burmistrova
In chronic experiments on immature rabbits receiving therapeutic courses of vancomycin, gentamicin, and consecutive administration of vancomicin and gentamicin by the scheme used in neonatology, hearing function was evaluated by the methods of auditory evoked potentials (auditory brainstem response, ABR) and distortion product otoacoustic emission (DPOAE). Comparison with the control group revealed ototoxic effects of all studied antibiotics that manifested in increased sound tolerance and more rapid shortening of latencies in 30-100 dB range...
August 2015: Bulletin of Experimental Biology and Medicine
Goce Dimeski, Kendra Bassett, Nigel Brown
INTRODUCTION: Gentamicin due to its low level of resistance and rapid bactericidal activity is commonly used to treat gram-negative bacteria. However, due to its toxic effects it needs to be monitored. To date, no interference has been reported with gentamicin assays. MATERIALS AND METHODS: A patient with leg cellulitis and sepsis received a single dose of gentamicin and a sample was sent for gentamicin analysis. The sample showed high blank absorbance readings on Beckman DxC800 and DC800 analysers with various dilutions...
2015: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
Sabrina J Moyo, Said Aboud, Mabula Kasubi, Samuel Y Maselle
Urinary tract infection (UTI) during pregnancy may cause complications such as pyelonephritis, hypertensive disease of pregnancy, anaemia, chronic renal failure, premature delivery and foetal mortality. This study aimed to identify the etiologic agents of UTI and to determine the patterns of antimicrobial drug susceptibility among pregnant women at Muhimbili National Hospital in Tanzania. Retrospective analysis of 200 mid-stream urine specimens processed for culture and antimicrobial drug susceptibility testing between January 2007 and December 2009 was carried out...
October 2010: Tanzania Journal of Health Research
Valentin Brodszky, László Gulácsi, Endre Ludwig, Gyula Prinz, János Banai, Péter Reményi, Bálint Strbák, Adrienne Kertész, Irén Kopcsóné Németh, Edit Zsoldiné Urbán, Petra Baji, Márta Péntek
INTRODUCTION: Clostridium difficile is the leading cause of antibiotic associated infectious nosocomial diarrhoea. Limited number of new pharmaceutical products have been developed and registered in the past decades for the treatment of Clostridium difficile infection. The available scientific evidence is limited and hardly comparable. AIM: To analyse the clinical efficacy and safety of metronidazole, vancomycin and fidaxomicin in the therapy of Clostridium difficile infection...
June 9, 2013: Orvosi Hetilap
Marco Mosele, Nicola Veronese, Francesco Bolzetta, Enzo Manzato, Giuseppe Sergi
Corynebacterium macginleyi is a gram positive rod that causes especially ocular infections: since now only six elderly cases of extraocular infection are described. A 76 years old bedridden woman with a central venous catheter was hospitalized for 10 days of persistent fever. She was treated before with vancomicin and then with imipenem. The clinical conditions improved and the patient was discharged after two weeks of hospitalization. Among recognised risk factors for this infection the advanced age, indwelling devices and immunosuppression seem the most important...
January 2012: New Microbiologica
A Herrero Varas, I San Martín García, L Moreno Galarraga, M Herranz Aguirre, J C García Romero, E Bernaola Iturbe
We present the case of 9 year old male referred to the A and E service with right ocular proptosis and progressive migraine in the context of a sinusitis diagnosed two days earlier by compatible clinical and radiological tests, and receiving treatment with amoxicillin-clavulanic acid. Physcial exploration revealed right ocular proptosis with a slight limitation for conjugate gaze. Facing the suspicion of a possible neurological complication of the sinusitis, cranial computer aided tomography (CAT) was carried out, with right frontal subdural empyema observed...
September 2011: Anales del Sistema Sanitario de Navarra
N Avazashvili, T Nozadze, D Chikviladze, Kh Gachechiladze, D Metreveli, M Mikeladze
In this article there are given results of microbiological investigation of nosocomial pneumonia agents, microbial structure. Investigation was held in 727 cases of traumatological patients treated because of hip replacement or osteosinthesis of limbs. Complications with nosocomial pneumonia was found in 27 cases (3,7%). In 27 cases of diagnosed pneumonia, 66 microbial strains were isolated. In 4 cases (14,8%) was detected mono infection, different microbial association were isolated in 23 cases (85,2%) - 2 microbes in 7 and 3 microbes in 16 cases...
May 2011: Georgian Medical News
D Chikviladze, Kh Gachechiladze, M Mikeladze, D Metreveli, D Avazashvili
The aim of the article was to determine the structure of infections agents in diabetic foot infections and their sensibility to antibiotics A total of 295 microbial isolates were obtained from 115 patients with confirmed diabetic foot infection, treated in 2005-2009 years. Of these aerobes were found in 92.88%, anaerobes - in 7.12%. Microbal associations, various aerbal bacteria were found in 58,49% of cases, associations of aerobes with anaerobes - in 17.92% of cases; from 21.70% of patients were isolated microbial monocultures...
June 2010: Georgian Medical News
Zehra Yuksekdag, Belma Aslim
In this study, the metabolic activities of five strains of amount of Pediococcus spp. in terms of the quantities they produced of lactic acid, hydrogen peroxide, exopolysaccharides and proteolytic activity were determined. Lactic acid levels produced by these strains were found to be in the range of 2.5-5.6 mg/ml. All strains produced hydrogen peroxide. The P. pentosaceus Z13P strain produced the maximum amount (0.25 mg/ml) of proteolytic activity. Exopolysaccharide (EPS) production by the Pediococcus strains during growth in MRS medium was in the range 25-64 mg/l...
January 2010: Journal of Microbiology and Biotechnology
Stephanie Braun J, Alberto Fica C, Daniela Andrighetti B, Lorena Porte T, Vjera Triantafilo V
Since the appearance of Vancomicin-resistant enterococci (VRE) in our country, the Chilean Ministry of Health recommended the surveillance of intestinal colonization in patients in critical wards. We report the results of surveillance in ICU and onco-hematological wards from 2002 to 2008, with analysis of possible risk factors: demographical data, use and type of antibiotic, days of hospitalization prior to sampling, and year of hospitalization. Colonization rate increased from 0.03 cases per 1000 bed-days in 2003 to 0...
August 2009: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Myra S Wilson, Carola L Otth, Gustavo S Medina, Laura R Otth, Heriberto J Fernández, María Arce, Angela C Zaror, Víctor Lizama, Mónica D Gil, Ana María von Chrismar
BACKGROUND: Methicillin resistant strains of Staphylococcus aureus (MRSA) are an important cause of nosocomial infections. AIM: To determine the genotypes of MRSA strains. MATERIAL AND METHODS: Fifty five strains of MRSA, isolated from patients hospitalized in Hospital Base Valdivia, were studied. The phenotype was determined through MicroScan in all strains and by minimum inhibitory concentration (MIC) in 41. The genotype of the strains was analyzed by a duplex polymerase chain reaction (PCR) of the mecA gene, amplifying eight hypervariable DNA regions associated to such gene...
May 2007: Revista Médica de Chile
Paulo Roberto Lerias de Almeida, Nutianne Schneider Camargo, Maximilhano Arenz, Cristiane Valle Tovo, Bruno Galperim, Paulo Behar
BACKGROUND: Spontaneous bacterial peritonitis is a serious complication in cirrhotic patients, and the changes in the microbiological characteristics reported in the last years are impacting the choice of antibiotic used in the treatment. AIM: To evaluate the change in the epidemiology and antibiotic resistance of the bacteria causing spontaneous bacterial peritonitis in a 7 years period. METHODS: All the cases of cirrhotic patients with spontaneous bacterial peritonitis with positive cultural examination were retrospectively studied...
January 2007: Arquivos de Gastroenterologia
Hideya Kokubun, Toshimi Kimura, Kazuo Yago
Aminoglycosides are mainly distributed in the extracellular fluid, so when they are given to neonates who have a large amount of extracellular fluid, their distribution is increased. In our data, the volume of distribution (Vd) of Arbekacin in the neonates was twice that of the adults, 0.54 l/kg. Therefore, the dose per weight of aminoglycosides to the neonates should be increased more than to the adults. In the renal function of the neonates, differentiation of the nephron is completed within 36 weeks after conception, but it is functionally immature...
June 2007: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Hideta Nakamura, Shunichi Kinjyo, Hirosi Kaneshima, Jiro Fujita
Endogenous endophthalmitis (EBE) is intraocular infection usually associated by bcteremia. Although, EBE is an uncommon disease, visually prognosis is very poor. Immune suppressive disease, such as diabetes or malignancy is a predisposing factor of EBE. Although, in east Asia, including Japan, gram negative organisms reported as common pathogen causing EBE, we here repot a case of group B streptococcus EBE. A 53- year old man, who has history of diabetes mellitus, was admitted to our hospital with compliant of sudden visual loss and pain at his right eye...
May 2006: Kansenshōgaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
B Martín, M Garriga, M Hugas, S Bover-Cid, M T Veciana-Nogués, T Aymerich
The population of Gram-positive catalase-positive cocci from slightly fermented sausages was characterized at species and strain level by molecular techniques and some technological and hygienic aspects were also considered. Staphylococcus xylosus was the predominant species (80.8%) followed by Staphylococcus warneri (8.3%), Staphylococcus epidermidis (5.8%) Staphylococcus carnosus (4.6%), and Kocuria varians (0.4%). Proteolytic activity was observed in 23% of the isolates. The species with the highest percentage of proteolytic strains was S...
March 15, 2006: International Journal of Food Microbiology
Ken Katou, Atsushi Nakamura, Takashi Kato, Ken Tonegawa, Takeo Kutsuna, Toshiaki Niwa, Hiroki Morita, Makoto Itoh
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa are the main causes of refractory infections that are often resistant to antimicrobial agents. In these cases, combination of agents with antimicrobial activity is being examined. However, few studies have investigated combined effects with antimicrobial agents including carbapenem and aminoglycosides. METHODS: We evaluated the effects of panipenem (PAPM) combined with 3 aminoglycosides, arbekacin, amikacin, and netilmicin, and vancomicin (VCM) with an agar dilution checkerboard technique and the fractional inhibitory concentration index against 47 strains of MRSA and 56 strains of P...
October 2005: Chemotherapy
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