keyword
https://read.qxmd.com/read/38383596/a-convergent-evolutionary-pathway-attenuating-cellulose-production-drives-enhanced-virulence-of-some-bacteria
#1
JOURNAL ARTICLE
Nguyen Thi Khanh Nhu, M Arifur Rahman, Kelvin G K Goh, Seung Jae Kim, Minh-Duy Phan, Kate M Peters, Laura Alvarez-Fraga, Steven J Hancock, Chitra Ravi, Timothy J Kidd, Matthew J Sullivan, Katharine M Irvine, Scott A Beatson, Matthew J Sweet, Adam D Irwin, Jana Vukovic, Glen C Ulett, Sumaira Z Hasnain, Mark A Schembri
Bacteria adapt to selective pressure in their immediate environment in multiple ways. One mechanism involves the acquisition of independent mutations that disable or modify a key pathway, providing a signature of adaptation via convergent evolution. Extra-intestinal pathogenic Escherichia coli (ExPEC) belonging to sequence type 95 (ST95) represent a global clone frequently associated with severe human infections including acute pyelonephritis, sepsis, and neonatal meningitis. Here, we analysed a publicly available dataset of 613 ST95 genomes and identified a series of loss-of-function mutations that disrupt cellulose production or its modification in 55...
February 21, 2024: Nature Communications
https://read.qxmd.com/read/38284437/association-of-the-neutrophil-lymphocyte-ratio-with-outcome-in-sick-hospitalized-neonatal-foals
#2
JOURNAL ARTICLE
Amanda N Samuels, Ahmed M Kamr, Stephen M Reed, Nathan M Slovis, Laura D Hostnik, Teresa A Burns, Ramiro E Toribio
BACKGROUND: The neutrophil-lymphocyte ratio (NLR) in human medicine is an objective biomarker that reflects prognosis. The NLR as an independent biomarker to help predict nonsurvival in hospitalized neonatal foals has not been thoroughly interrogated. OBJECTIVES/HYPOTHESIS: Retrospectively evaluate if the NLR at admission is associated with nonsurvival in sick hospitalized foals <4 days old. We hypothesized that a lower NLR will be associated with nonsurvival...
January 29, 2024: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/38263289/an-il-10-del-1-axis-supports-granulopoiesis-and-survival-from-sepsis-in-early-life
#3
JOURNAL ARTICLE
Eleni Vergadi, Ourania Kolliniati, Ioanna Lapi, Eleftheria Ieronymaki, Konstantina Lyroni, Vasileia Ismini Alexaki, Eleni Diamantaki, Katerina Vaporidi, Eleftheria Hatzidaki, Helen A Papadaki, Emmanouil Galanakis, George Hajishengallis, Triantafyllos Chavakis, Christos Tsatsanis
The limited reserves of neutrophils are implicated in the susceptibility to infection in neonates, however the regulation of neutrophil kinetics in infections in early life remains poorly understood. Here we show that the developmental endothelial locus (DEL-1) is elevated in neonates and is critical for survival from neonatal polymicrobial sepsis, by supporting emergency granulopoiesis. Septic DEL-1 deficient neonate mice display low numbers of myeloid-biased multipotent and granulocyte-macrophage progenitors in the bone marrow, resulting in neutropenia, exaggerated bacteremia, and increased mortality; defects that are rescued by DEL-1 administration...
January 23, 2024: Nature Communications
https://read.qxmd.com/read/38173520/neutrophil-extracellular-traps-in-adult-diseases-and-neonatal-bacterial-infectious-diseases-a-review
#4
REVIEW
Ziheng Li, Tianming Yuan
Neutrophils, the most abundant type of white blood cells, are pivotal in fighting bacterial infections due to their immunological and anti-infection capabilities. In recent years, scientists have discovered a novel mechanism known as neutrophil extracellular traps, which are fibrous networks primarily released by neutrophils that combat bacterial infections. There is a growing interest in studying NETs and their role in human infectious diseases, particularly in neonates susceptible to bacterial infections...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38135115/the-effects-of-antibiotic-therapy-on-neonatal-sepsis-associated-acute-kidney-injury
#5
JOURNAL ARTICLE
Irina B Pevzner, Anna A Brezgunova, Vasily A Popkov, Mikhail Y Sintsov, Nadezda V Andrianova, Ljubava D Zorova, Denis N Silachev, Artem A Burov, Yulia L Podurovskaya, Dmitry B Zorov, Egor Y Plotnikov, Gennady T Sukhikh
AIM: Neonatal sepsis remains one of the most dangerous conditions in the neonatal intensive care units. One of the organs affected by sepsis is the kidney, making acute kidney injury (AKI) a common complication of sepsis. Treatment of sepsis almost always involves antibiotic therapy, which by itself may cause some adverse effects, including nephrotoxicity. We analyzed the mutual effect of antibiotic therapy and sepsis on AKI in an experimental and clinical study in neonatal infants and rats...
December 20, 2023: Life Sciences
https://read.qxmd.com/read/38086850/harnessing-bioengineered-myeloid-progenitors-for-precision-immunotherapies
#6
REVIEW
Willem Buys, Elias T Zambidis
Granulocytes and macrophages are the frontline defenders of the innate immune system. These myeloid cells play a crucial role in not only eliminating pathogens and tumor cells, but also regulating adaptive immune responses. In neonatal sepsis and post-chemotherapy agranulocytosis, the absence of these cells leaves the host highly vulnerable to infections. Beyond replacement to prevent or control neutropenic sepsis, engineered myeloid cells may offer distinct opportunities for cell therapies. For example, the mobility and specific homing capacities of neutrophils to sites of inflammation could be exploited to deliver biocidal agents, or anti-inflammatory healing signals during sepsis, autoimmunity, and organ transplantation...
December 12, 2023: NPJ Regenerative Medicine
https://read.qxmd.com/read/38012554/meta-analysis-of-the-role-of-neutrophil-to-lymphocyte-ratio-in-neonatal-sepsis
#7
JOURNAL ARTICLE
Jingyang Chen, Sanaz Yasrebinia, Arshin Ghaedi, Monireh Khanzadeh, Stephan Quintin, Abeer Dagra, Rodeania Peart, Brandon Lucke-Wold, Shokoufeh Khanzadeh
INTRODUCTION: The neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, measures innate-adaptive immune system balance. In this systematic review and meta-analysis, we aim to analyze the current literature to evaluate the diagnostic role of NLR in neonatal sepsis. METHODS: PubMed, Web of Science, and Scopus were used to conduct a systematic search for relevant publications published before May 14, 2022. RESULTS: Thirty studies, including 2328 neonates with sepsis and 1800 neonates in the control group, were included in our meta-analysis...
November 28, 2023: BMC Infectious Diseases
https://read.qxmd.com/read/37814753/unraveling-leukocyte-profile-shifts-and-platelet-dynamics-following-leukoreduced-packed-red-cell-transfusions-in-very-low-birth-weight-preterm-neonates
#8
JOURNAL ARTICLE
Palanikumar Balasundaram, Sharef Waadallah Al-Mulaabed, Kim Roger
Background Packed red blood cell (PRBC) transfusions are routine in neonatal care and the most common blood product administered to sick neonates. However, their impact on leukocyte and platelet profiles in very low birth weight (VLBW) preterm infants remains largely unexplored. This study examines leukocyte profile shifts and platelet dynamics following leukoreduced PRBC transfusions in VLBW preterm infants, offering insights to improve neonatal care and reduce unnecessary interventions. Methods The study utilized a retrospective cohort design within a single center, focusing on VLBW preterm infants who received PRBC transfusions at a level 3 NICU between January 2014 and June 2019...
September 2023: Curēus
https://read.qxmd.com/read/37600908/serum-calprotectin-as-a-marker-of-neonatal-sepsis-a-hospital-based-cross-sectional-diagnostic-study
#9
JOURNAL ARTICLE
Pardha Ramineni, Sowmini Padmanabh Kamath, Poornima Manjrekar, Padmanabh Kamath, Prasanna Mithra, Vaman Kulkarni
Background:  Despite significant advances in neonatal care, neonatal sepsis remains a major contributor to mortality, morbidity, and protracted hospitalization. The development of early possible diagnostic indicators for newborn sepsis is critical. Since calprotectin participates in major biological processes, it could be a diagnostic marker for infection/inflammation. This study aimed to estimate serum calprotectin in neonates with clinical sepsis. In addition, we compared serum calprotectin with standard sepsis markers and serum procalcitonin to evaluate its diagnostic accuracy...
2023: F1000Research
https://read.qxmd.com/read/37572503/prognostic-value-of-blood-inflammatory-parameters-for-predicting-mortality-in-neonates-with-sepsis
#10
JOURNAL ARTICLE
Xianghui Liang, Huijuan Luo, Xia Chen, Xiaohe Yu, Qun Yan
BACKGROUND: Neonatal sepsis is a major cause of morbidity and mortality in neonates. The diagnosis of neonatal sepsis has been widely explored using blood inflammatory parameters. However, few researches have focused on the predictive significance of blood inflammation parameters for predicting mortality. This study aimed to evaluate the prognostic value of blood inflammatory parameters, including white blood cell (WBC), neutrophil, lymphocyte, monocyte, platelet and C-reactive protein (CRP) for predicting mortality in neonates with sepsis...
August 10, 2023: International Immunopharmacology
https://read.qxmd.com/read/37509492/bioinformatic-analysis-and-machine-learning-methods-in-neonatal-sepsis-identification-of-biomarkers-and-immune-infiltration
#11
JOURNAL ARTICLE
Zhou Jiang, Yujia Luo, Li Wei, Rui Gu, Xuandong Zhang, Yuanyuan Zhou, Songying Zhang
The disease neonatal sepsis (NS) poses a serious threat to life, and its pathogenesis remains unclear. Using the Gene Expression Omnibus (GEO) database, differentially expressed genes (DEGs) were identified and functional enrichment analyses were conducted. Three machine learning algorithms containing the least absolute shrinkage and selection operator (LASSO), support vector machine recursive feature elimination (SVM-RFE), and random forest (RF) were applied to identify the optimal feature genes (OFGs). This study conducted CIBERSORT to present the abundance of immune infiltrates between septic and control neonates and assessed the relationship between OFGs and immune cells...
June 28, 2023: Biomedicines
https://read.qxmd.com/read/37448924/role-of-neonatal-cerebrospinal-fluid-cytology-in-correlation-to-c-reactive-protein-blood-culture-risk-factors-and-clinical-outcomes-in-neonatal-intensive-care
#12
JOURNAL ARTICLE
Prita Pradhan, Reshmi Mishra, Santosh Kumar Panda, Ranjita Panigrahi, Urmila Senapati, Rajlaxmi Sarangi, Kumudini Panigrahi
INTRODUCTION: The number of neonatal cerebrospinal fluid (CSF) samples sent from the neonatal intensive care unit (NICU) for cytologic examination is rising, warranting accurate analysis and interpretation of the same. This study was taken up to assess the usefulness of CSF cell count and cytology in NICU settings, as it can be used even in a resource-limited setting. AIM AND OBJECTIVE: 1) To study the prevalence of cell count and cytologic changes in CSF from NICU and assess their usefulness in correlation to C-reactive protein, CSF neutrophil percentage, blood, CSF culture, and other biochemical parameters...
May 2023: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/37398776/evaluation-of-haematological-parameters-and-uric-acid-in-the-diagnosis-of-late-onset-neonatal-sepsis
#13
JOURNAL ARTICLE
Zeynep Yılmaz Oztorun
Introduction A number of parameters studied in a whole blood count can be helpful in the diagnosis of neonatal sepsis. The platelet/lymphocyte ratio (PLR) is a systemic inflammatory marker in early sepsis and has been used as a diagnostic indicator in cardiovascular events and cancer. Being one of the major antioxidants in human biological fluids, serum uric acid is responsible for neutralising free radicals. The red cell distribution width/platelet ratio (RPR) is a diagnostic marker in adult inflammatory diseases...
May 2023: Curēus
https://read.qxmd.com/read/37391699/comparison-of-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-for-the-diagnosis-of-neonatal-sepsis-a-systematic-review-and-meta-analysis
#14
JOURNAL ARTICLE
Lixia Bai, Peihui Gong, Xiaoyun Jia, Xinhua Zhang, Xiuhui Li, Yueqin Zhang, Hao Zhou, Yanan Kang
PURPOSE: To compare the performance of Neutrophil-to-Lymphocyte Ratio (NLR) with that of Platelet-to-Lymphocyte Ratio (PLR) in diagnosing neonatal sepsis (NS). METHODS: PubMed and Embase were searched for relevant studies from the inception of the databases to May, 2022. The pooled sensitivity (SEN), specificity (SPE), and area under the receiver operator characteristic curve (AUC) were measured. RESULTS: Thirteen studies involving 2610 participants were included...
June 30, 2023: BMC Pediatrics
https://read.qxmd.com/read/37373467/increased-expression-of-anaphylatoxin-c5a-receptor-1-in-neutrophils-and-natural-killer-cells-of-preterm-infants
#15
JOURNAL ARTICLE
Hannah Boeckel, Christian M Karsten, Wolfgang Göpel, Egbert Herting, Jan Rupp, Christoph Härtel, Annika Hartz
Preterm infants are susceptible to infection and their defense against pathogens relies largely on innate immunity. The role of the complement system for the immunological vulnerability of preterm infants is less understood. Anaphylatoxin C5a and its receptors C5aR1 and -2 are known to be involved in sepsis pathogenesis, with C5aR1 mainly exerting pro-inflammatory effects. Our explorative study aimed to determine age-dependent changes in the expression of C5aR1 and C5aR2 in neonatal immune cell subsets. Via flow cytometry, we analyzed the expression pattern of C5a receptors on immune cells isolated from peripheral blood of preterm infants (n = 32) compared to those of their mothers (n = 25)...
June 19, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37238320/serum-ykl-40-as-a-potential-biomarker-for-sepsis-in-term-neonates-a-pilot-study
#16
JOURNAL ARTICLE
Evangelia Steletou, Dimitra Metallinou, Alexandra Margeli, Theodoros Giannouchos, Athanasios Michos, Christina Kanaka-Gantenbein, Ioannis Papassotiriou, Tania Siahanidou
Although YKL-40 is a promising diagnostic biomarker of sepsis in adults, its value in neonatal sepsis is not known. The study objectives included assessing the levels and diagnostic value of serum YKL-40 in term neonates with sepsis and comparing YKL-40 with other commonly used inflammatory biomarkers. In this pilot case-control study, 45 term neonates (30 septic and 15 non-septic, as controls), 4 to 28 days old, were prospectively studied. The International Pediatric Sepsis Consensus Conference criteria were applied to diagnose sepsis...
April 25, 2023: Children
https://read.qxmd.com/read/37200285/use-of-admission-serum-neutrophil-gelatinase-associated-lipocalin-ngal-concentrations-as-a-marker-of-sepsis-and-outcome-in-neonatal-foals
#17
JOURNAL ARTICLE
Malene Laurberg, Claude Saegerman, Stine Jacobsen, Lise C Berg, Sigrid Hyldahl Laursen, Emma Hoeberg, Elaine Alexandra Sånge, Gaby van Galen
BACKGROUND: Equine neonatal sepsis can be challenging to diagnose and prognosticate. Neutrophil gelatinase-associated lipocalin (NGAL), a new marker of renal damage and inflammation, can potentially be helpful. OBJECTIVES: To evaluate NGAL in neonatal foals with sepsis, and assess its relation to outcome. ANIMALS: Foals ≤ 14 days, with admission blood analysis and stored serum. METHODS: NGAL was measured on stored serum from 91 foals...
2023: PloS One
https://read.qxmd.com/read/37152314/acute-kidney-injury-post-abdominal-surgery-in-infants-implications-for-prevention-and-management
#18
REVIEW
Minh Dien Duong, Silvia Kwak, Naina Bagrodia, Abby Basalely
Acute kidney injury (AKI) is common in critically ill infants and is associated with long-term sequelae including hypertension and chronic kidney disease. The etiology of AKI in infants is multifactorial. There is robust literature highlighting the risk of AKI after cardiothoracic surgery in infants. However, risk factors and outcomes for AKI in infants after abdominal surgery remains limited. This article reviews the epidemiology and association of abdominal surgery with postoperative AKI and suggests methods for AKI management and prevention...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/37119248/evaluation-of-mean-neutrophil-volume-and-immature-to-total-neutrophil-ratio-as-a-biomarker-for-bacterial-sepsis-in-adult-patients
#19
JOURNAL ARTICLE
S N A Md Shahid, A Ithnin, R Z A Raja Sabudin, H Alauddin, T L Tan
INTRODUCTION: Mean neutrophil volume (MNV) and immature to total neutrophil ratio (IT Ratio) has been found to support the detection of sepsis in elderly and neonates. This study aimed to assess the diagnostic significance of MNV and IT ratio in adult sepsis population. MATERIALS AND METHODS: Sixty-four adult patients presented with suspected bacterial sepsis were included in this study. Relevant cultures and/or pertinent serology tests were performed. Full blood counts were analysed for MNV and IT ratio...
April 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37063850/corrigendum-neonatal-net-inhibitory-factor-improves-survival-in-the-cecal-ligation-and-puncture-model-of-polymicrobial-sepsis-by-inhibiting-neutrophil-extracellular-traps
#20
Claudia V de Araujo, Frederik Denorme, W Zac Stephens, Qing Li, Mark J Cody, Jacob L Crandell, Aaron C Petrey, Kimberly A Queisser, John L Rustad, James M Fulcher, Judah L Evangelista, Michael S Kay, Joshua D Schiffman, Robert A Campbell, Christian C Yost
[This corrects the article DOI: 10.3389/fimmu.2022.1046574.].
2023: Frontiers in Immunology
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