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crohn’s disease

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https://www.readbyqxmd.com/read/29474531/subtherapeutic-infliximab-trough-levels-and-complete-mucosal-healing-are-associated-with-sustained-clinical-remission-after-infliximab-cessation-in-paediatric-onset-crohn-s-disease-patients-treated-with-combined-immunosuppressive-therapy
#1
Ben Kang, So Yoon Choi, Young Ok Choi, Min-Ji Kim, Kyunga Kim, Ji-Hyuk Lee, Yon Ho Choe
Background and aims: We aimed to investigate the outcome in paediatric-onset Crohn's disease patients who had discontinued infliximab after maintaining clinical remission with combined immunosuppression, and to determine factors associated with clinical relapse. Methods: We conducted a retrospective observational study of 63 paediatric-onset Crohn's disease patients who had stopped scheduled infliximab during sustained corticosteroid-free clinical remission for at least 1 year with infliximab and azathioprine, and were followed up for at least 1 year thereafter...
February 21, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29473429/a-safety-evaluation-of-budesonide-mmx-for-the-treatment-of-ulcerative-colitis
#2
Cristina Bezzio, Stefano Festa, Giulia Zerboni, Claudio Papi, Gianpiero Manes, Simone Saibeni
Budesonide belongs to low-bioavailability steroids class. A novel oral formulation of budesonide, which uses the Multi-Matrix System (MMX) for delivering drugs to the colon, is now available as a possible treatment of ulcerative colitis patients intolerant or not-responding to first-line therapy with 5-ASA. Areas covered: in this review we present information about the development and the use of budesonide MMX and we provide data about its mechanism of action as well as, pharmacodynamics and pharmacokynetics...
February 23, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29471605/-emerging-therapies-what-are-promising-in-the-near-future
#3
REVIEW
Geom Seog Seo, Sung Hee Lee
The treatment of inflammatory bowel disease has evolved with the development of anti-TNF agents. In spite of long-term effectiveness, many patients do not respond or no longer responds to these drugs. Therefore, the development of new drugs that act on different inflammatory pathways has become necessary. Vedolizumab, a gut-specific biological agent, inhibits interaction α4β7 integrin with mucosal addressin cell adhesion molecule-1 without inhibiting systemic immune responses. Long-term vedolizumab therapy in patients with Crohn's disease and ulcerative colitis was safe and effective...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29471602/-evolving-therapeutic-strategies-in-the-inflammatory-bowel-disease
#4
REVIEW
Soo Young Na, Won Moon
It is important to have effective therapeutic strategies and goals in clinical practice and research of inflammatory bowel disease. Conventional end points for clinical trials in Crohn's disease and ulcerative colitis have been based on composite indices, such as the Crohn's Disease Activity Index and the Mayo Clinic Score. Although these indices have been shown to reduce the intestinal injury to some extent, satisfactory results have not been obtained in improving the quality of life of patients. Recently, alternative measures of outcome and definitions of response are being developed beyond symptoms...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29471381/efficacy-of-vedolizumab-in-fistulising-crohn-s-disease-exploratory-analyses-of-data-from-gemini-2
#5
Brian G Feagan, David Schwartz, Silvio Danese, David T Rubin, Trevor W Lissoos, Jing Xu, Karen Lasch
Background and Aims: Medical management of fistulising Crohn's disease (CD) is constrained by the limited number of available therapies. We evaluated the efficacy of vedolizumab, a gut-selective α4β7 integrin antagonist approved for treating moderately to severely active CD, in a subpopulation of patients with fistulising CD who participated in the GEMINI 2 trial (NCT00783692). Methods: Exploratory analyses of data from the GEMINI 2 trial were conducted in 461 responders to 6-week vedolizumab induction therapy who received maintenance placebo (VDZ/PBO, N=153) or vedolizumab (VDZ/VDZ, N=308)...
February 17, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29471349/intestinal-colonization-traits-of-pandemic-multidrug-resistant-escherichia-coli-st131
#6
Sohinee Sarkar, Melanie L Hutton, Dimitrios Vagenas, Rinaldo Ruter, Stephanie Schüller, Dena Lyras, Mark A Schembri, Makrina Totsika
Background: Epidemiological studies point to the gut as a key reservoir of multidrug resistant Escherichia coli multilocus sequence type 131 (ST131), a globally dominant pathogenic clone causing urinary tract and bloodstream infections. Here we report a detailed investigation of its intestinal lifestyle. Methods: Clinical ST131 isolates and type 1 fimbriae null mutants were assessed for colonization of human intestinal epithelia and in mouse intestinal colonization models...
February 16, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29470778/guselkumab-for-the-treatment-of-psoriasis
#7
REVIEW
Álvaro Machado, Tiago Torres
Psoriasis is a common, chronic, immune-mediated, inflammatory skin disease with systemic involvement and significant impact on patients' quality of life. Several biologic treatments have been developed in recent decades, such as tumor necrosis factor (TNF)-α inhibitors, a non-selective interleukin (IL)-23 inhibitor (ustekinumab, which also inhibits IL-12), and-most recently-IL-17 inhibitors. Guselkumab is a novel biological therapy that selectively targets IL-23 and is the first-in-class selective IL-23 inhibitor approved to treat moderate-to-severe plaque psoriasis...
February 22, 2018: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/29469723/mycobacterium-haemophilum-infection-in-a-renal-transplant-patient-with-inflammatory-bowel-disease
#8
Steven Krueger, Jillian Rork, Jennifer Lee, Kristine Cornejo, Laura Gibson, Jennifer S Daly, Nikki A Levin
A 61-year-old immunosuppressed renal transplant patient with inflammatory bowel disease presented with tender pink nodules on the trunk and extremities. An initial biopsy was suggestive of metastatic Crohn disease, but after disease persistence, a second biopsy revealed disseminated Mycobacterium haemophilum. Atypical mycobacterial infections should be considered in immunosuppressed patients. This case highlights the complexities of diagnosing such infections in patients with an underlying granulomatous condition and the particular growth requirements of M...
September 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469014/effect-of-mineral-status-and-glucocorticoid-use-on-bone-mineral-density-in-patients-with-crohn-s-disease
#9
Nayane R Pierote, Amanda F Braz, Susy L Barros, José M Moita Neto, José Miguel L Parente, Maria da Cruz M Silva, Mayara S Beserra, Nina Rosa M Soares, Dilina N Marreiro, Nadir do Noscimento Nogueira
OBJECTIVES: Crohn's disease (CD) is a condition that is characterized by chronic inflammation. The presence of multifactorial pathogenesis that results from inflammation is associated with low micronutrient consumption and glucocorticoid use, which may be related to bone health. This study aimed to evaluate the relationship between dietary mineral intake and glucocorticoid use in bone mineral density (BMD) in patients with CD. METHODS: A cross-sectional study of 62 patients with CD ages 20 y to 40 y measured their macro- and micronutrient intake with a 3-d food record...
November 27, 2017: Nutrition
https://www.readbyqxmd.com/read/29468143/metagenomic-characterization-of-the-human-intestinal-microbiota-in-fecal-samples-from-stec-infected-patients
#10
Federica Gigliucci, F A Bastiaan von Meijenfeldt, Arnold Knijn, Valeria Michelacci, Gaia Scavia, Fabio Minelli, Bas E Dutilh, Hamideh M Ahmad, Gerwin C Raangs, Alex W Friedrich, John W A Rossen, Stefano Morabito
The human intestinal microbiota is a homeostatic ecosystem with a remarkable impact on human health and the disruption of this equilibrium leads to an increased susceptibility to infection by numerous pathogens. In this study, we used shotgun metagenomic sequencing and two different bioinformatic approaches, based on mapping of the reads onto databases and on the reconstruction of putative draft genomes, to investigate possible changes in the composition of the intestinal microbiota in samples from patients with Shiga Toxin-producing E...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29467827/advanced-imaging-techniques-for-small-bowel-crohn-s-disease-what-does-the-future-hold
#11
REVIEW
Inês Pita, Fernando Magro
Treatment of Crohn's disease (CD) is intrinsically reliant on imaging techniques, due to the preponderance of small bowel disease and its transmural pattern of inflammation. Ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) are the most widely employed imaging methods and have excellent diagnostic accuracy in most instances. Some limitations persist, perhaps the most clinically relevant being the distinction between inflammatory and fibrotic strictures. In this regard, several methodologies have recently been tested in animal models and human patients, namely US strain elastography, shear wave elastography, contrast-enhanced US, magnetization transfer MRI and contrast dynamics in standard MRI...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29467549/glucose-transporter-expression-in-the-human-colon
#12
Flavia Merigo, Alessandro Brandolese, Sonia Facchin, Silvia Missaggia, Paolo Bernardi, Federico Boschi, Renata D'Incà, Edoardo Vincenzo Savarino, Andrea Sbarbati, Giacomo Carlo Sturniolo
AIM: To investigate by immunostaining glucose transporter expression in human colorectal mucosa in controls and patients with inflammatory bowel disease (IBD). METHODS: Colorectal samples were obtained from patients undergoing lower endoscopic colonoscopy or recto-sigmoidoscopy. Patients diagnosed with ulcerative colitis ( n = 18) or Crohn's disease ( n = 10) and scheduled for diagnostic colonoscopy were enrolled. Patients who underwent colonoscopy for prevention screening of colorectal cancer or were followed-up after polypectomy or had a history of lower gastrointestinal symptoms were designated as the control group (CTRL, n = 16)...
February 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29467539/editorial-increasing-incidence-of-pediatric-inflammatory-bowel-disease-in-france-implications-for-etiology-diagnosis-prognosis-and-treatment
#13
Edward L Barnes, Michael D Kappelman
The significant increase in pediatric-onset inflammatory bowel disease in recent decades appears to be a global phenomenon, with studies from multiple geographic areas noting an increase in Crohn's disease (CD) and ulcerative colitis (UC). In this large, population-based cohort from northern France, the rapid increase in pediatric CD and UC from 1988-2011 may be due to multiple potential etiologies including environmental factors and advancements in diagnostic capabilities. We should consider the clinical implications of this rise in incidence, including potential risk stratification approaches that may offer the ability to modify the disease course of patients with earlier diagnosis...
February 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29466790/elevated-faecal-calprotectin-levels-are-a-reliable-non-invasive-screening-tool-for-small-bowel-crohn-s-disease-in-patients-undergoing-capsule-endoscopy
#14
Hamid Yousuf, Umair Aleem, Roisin Egan, Pardeep Maheshwari, Jafaar Mohamad, Deidre McNamara
BACKGROUND: Approximately 10% of Crohn's disease (CD) patients have this disease affecting the small bowel (SB) beyond the reach of Ileo-colonoscopy. Capsule endoscopy (SBCE) is the recommended investigation for SB disease. An accurate and inexpensive biomarker would help identify at-risk patients. AIM: To examine the efficacy of faecal calprotectin (FC) and C-reactive protein (CRP) as predictors of SBCE findings in suspected and known CD. METHODS: A prospective observational study...
February 21, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29466406/increased-fecal-calprotectin-levels-in-crohn-s-disease-correlate-with-elevated-serum-th1-and-th17-associated-cytokines
#15
Arno R Bourgonje, Julius Z H von Martels, Paul de Vos, Klaas Nico Faber, Gerard Dijkstra
BACKGROUND: Patient-reported symptoms and endoscopic disease activity do not correlate well in Crohn's disease (CD). This warrants the need for reliable biomarkers to early detect active intestinal inflammation. Currently, the fecal calprotectin level is the most commonly used biomarker for inflammatory activity in CD. However, the diagnostic accuracy of the fecal calprotectin level is not fully efficacious and diagnosis may be further improved by the identification of other biomarkers for active CD...
2018: PloS One
https://www.readbyqxmd.com/read/29465542/the-small-bowel-diseases-detected-by-capsule-endoscopy-in-patients-with-chronic-abdominal-pain-a-retrospective-study
#16
Libin Huang, Zhiyin Huang, Yang Tai, Pu Wang, Bing Hu, Chengwei Tang
Chronic abdominal pain (CAP) remains a particular challenge because of its complicated causes, especially when the disorders involve the small bowel, where it is quite difficult to intubate the flexible endoscopes. This study was to investigate the small bowel diseases detected by capsule endoscopy (CE) in CAP patients to evaluate the role of CE on CAP, and analyzed the relationship among the clinical characteristics of CAP patients and the positive rates of CE findings to search for the indications of CE for CAP patients...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465373/anti-alpha-enolase-antibodies-in-beh%C3%A3-et-s-disease-a-marker-of-mucocutaneous-and-articular-disease-activity
#17
Leandro L Prado, Celio R Goncalves, Vilma T Viana, Carla G S Saad, Eloisa Bonfa
OBJECTIVES: To assess IgM anti-alpha-enolase antibodies (AAEA) in systemic Behçet's disease (BD) and its possible association with clinical manifestations and disease activity. METHODS: Ninety-seven consecutively selected BD patients were compared to 36 enteropathic spondyloarthritis (ESpA) [24 Crohn's disease (CD) and 12 ulcerative colitis (UC)] patients and 87 healthy controls. IgM AAEA was detected by immunoblotting. Disease activity was assessed by standardised indexes, Brazilian BD Current Activity Form (BR-BDCAF) for BD and Harvey-Bradshaw Index (HBI) for CD and UC patients...
February 7, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29464744/primary-perianal-adenocarcinoma-of-intestinal-type-a-new-proposed-entity
#18
Pelvender S Gill, Newton A C S Wong
AIMS: The currently recognised subtypes of anal canal/perianal adenocarcinoma are those arising from low rectal mucosa or columnar cuff, fistula-related tumours and anal gland carcinoma. This following report presents two examples of a hitherto undescribed subtype of perianal adenocarcinoma with an intestinal phenotype. METHODS AND RESULTS: A 74 year old man had a perianal tumour locally excised whereas a 73 year old female underwent an abdominoperineal resection for perianal Paget's disease with an underlying carcinoma...
February 21, 2018: Histopathology
https://www.readbyqxmd.com/read/29464530/difference-in-regional-neural-fluctuations-and-functional-connectivity-in-crohn-s-disease-a-resting-state-functional-mri-study
#19
Chunhui Bao, Peng Liu, Huirong Liu, Xiaoming Jin, Yin Shi, Luyi Wu, Xiaoqing Zeng, Jianye Zhang, Di Wang, Vince D Calhoun, Jie Tian, Huangan Wu
Patients with Crohn's disease (CD) are shown to have abnormal changes in brain structures. This study aimed to further investigate whether these patients have abnormal brain activities and network connectivity. Sixty patients with CD and 40 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (fMRI) scans. Amplitude of low-frequency fluctuation (ALFF) and seed-based functional connectivity (FC) were used to assess differences in spontaneous regional brain activity and functional connectivity...
February 20, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29464273/-perianal-inflammatory-diseases-classification-and-imaging
#20
REVIEW
A-O Schäfer
During the past 30 years, classifications and scoring systems have been developed in order to evaluate and objectify the degree and activity of anorectal fistulas. Only a few of these disease-specific instruments have been adopted into daily clinical routine. Generally, clinicians tend to use global medical judgement rather than numeric activity indices, which often seem complex and time consuming. Activity scores in Crohn disease, however, appeared to be very useful in clinical trials regarding evaluation of therapy response...
February 20, 2018: Der Radiologe
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